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8 results on '"Fingas, Stella M."'

1. Association Between Genetic Risk for Type 2 Diabetes and Structural Brain Connectivity in Major Depressive Disorder

Author

Repple, Jonathan, König, Amelie, de Lange, Siemon C., Opel, Nils, Redlich, Ronny, Meinert, Susanne, Grotegerd, Dominik, Mauritz, Marco, Hahn, Tim, Borgers, Tiana, Leehr, Elisabeth J., Winter, Nils, Goltermann, Janik, Enneking, Verena, Fingas, Stella M., Lemke, Hannah, Waltemate, Lena, Dohm, Katharina, Richter, Maike, Mehler, David M.A., Holstein, Vincent, Gruber, Marius, Nenadic, Igor, Krug, Axel, Brosch, Katharina, Schmitt, Simon, Stein, Frederike, Meller, Tina, Jansen, Andreas, Steinsträter, Olaf, Amare, Azmeraw T., Kircher, Tilo, Baune, Bernhard T., van den Heuvel, Martijn P., and Dannlowski, Udo

Published
2022
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2. Severity of current depression and remission status are associated with structural connectome alterations in major depressive disorder

Author

Repple, Jonathan, Mauritz, Marco, Meinert, Susanne, de Lange, Siemon C., Grotegerd, Dominik, Opel, Nils, Redlich, Ronny, Hahn, Tim, Förster, Katharina, Leehr, Elisabeth J., Winter, Nils, Goltermann, Janik, Enneking, Verena, Fingas, Stella M., Lemke, Hannah, Waltemate, Lena, Nenadic, Igor, Krug, Axel, Brosch, Katharina, Schmitt, Simon, Stein, Frederike, Meller, Tina, Jansen, Andreas, Steinsträter, Olaf, Baune, Bernhard T., Kircher, Tilo, Dannlowski, Udo, and van den Heuvel, Martijn P.

Published
2020
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3. Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group

Author

Leerssen, Jeanne, Blanken, Tessa F., Pozzi, Elena, Jahanshad, Neda, Aftanas, Lyubomir, Andreassen, Ole A., Baune, Bernhard T., Brack, Ivan, Carballedo, Angela, Ching, Christopher R. K., Dannlowski, Udo, Dohm, Katharina, Enneking, Verena, Filimonova, Elena, Fingas, Stella M., Frodl, Thomas, Godlewska, Beata R., Goltermann, Janik, Gotlib, Ian H., Grotegerd, Dominik, Gruber, Oliver, Harris, Mathew A., Hatton, Sean N., Hawkins, Emma, Hickie, Ian B., Jaworska, Natalia, Kircher, Tilo, Krug, Axel, Lagopoulos, Jim, Lemke, Hannah, Li, Meng, MacMaster, Frank P., McIntosh, Andrew M., McLellan, Quinn, Meinert, Susanne, Mwangi, Benson, Nenadić, Igor, Osipov, Evgeny, Portella, Maria J., Redlich, Ronny, Repple, Jonathan, Sacchet, Matthew D., Sämann, Philipp G., Simulionyte, Egle, Soares, Jair C., Walter, Martin, Watanabe, Norio, Whalley, Heather C., Yüksel, Dilara, Veltman, Dick J., Thompson, Paul M., Schmaal, Lianne, and Van Someren, Eus J. W.

Published
2020
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4. Association of disease course and brain structural alterations in major depressive disorder

Author

Lemke, Hannah, primary, Romankiewicz, Lina, additional, Förster, Katharina, additional, Meinert, Susanne, additional, Waltemate, Lena, additional, Fingas, Stella M., additional, Grotegerd, Dominik, additional, Redlich, Ronny, additional, Dohm, Katharina, additional, Leehr, Elisabeth J., additional, Thiel, Katharina, additional, Enneking, Verena, additional, Brosch, Katharina, additional, Meller, Tina, additional, Ringwald, Kai, additional, Schmitt, Simon, additional,  Stein, Frederike, additional, Steinsträter, Olaf, additional, Bauer, Jochen, additional, Heindel, Walter, additional, Jansen, Andreas, additional, Krug, Axel, additional, Nenadic, Igor, additional, Kircher, Tilo, additional, and Dannlowski, Udo, additional

Published
2022
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5. White matter fiber microstructure is associated with prior hospitalizations rather than acute symptomatology in major depressive disorder.

Author

Meinert, Susanne, Leehr, Elisabeth J., Grotegerd, Dominik, Repple, Jonathan, Förster, Katharina, Winter, Nils R., Enneking, Verena, Fingas, Stella M., Lemke, Hannah, Waltemate, Lena, Stein, Frederike, Brosch, Katharina, Schmitt, Simon, Meller, Tina, Linge, Anna, Krug, Axel, Nenadić, Igor, Jansen, Andreas, Hahn, Tim, and Redlich, Ronny

Subjects
CROSS-sectional method, DISEASE relapse, WHITE matter (Nerve tissue), ANISOTROPY, MENTAL depression, HOSPITAL care, FLUORIMETRY, DESCRIPTIVE statistics, PATHOLOGICAL psychology, LONGITUDINAL method
Abstract

Background: Eighty percent of all patients suffering from major depressive disorder (MDD) relapse at least once in their lifetime. Thus, understanding the neurobiological underpinnings of the course of MDD is of utmost importance. A detrimental course of illness in MDD was most consistently associated with superior longitudinal fasciculus (SLF) fiber integrity. As similar associations were, however, found between SLF fiber integrity and acute symptomatology, this study attempts to disentangle associations attributed to current depression from long-term course of illness. Methods: A total of 531 patients suffering from acute (N = 250) or remitted (N = 281) MDD from the FOR2107-cohort were analyzed in this cross-sectional study using tract-based spatial statistics for diffusion tensor imaging. First, the effects of disease state (acute v. remitted), current symptom severity (BDI-score) and course of illness (number of hospitalizations) on fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity were analyzed separately. Second, disease state and BDI-scores were analyzed in conjunction with the number of hospitalizations to disentangle their effects. Results: Disease state (pFWE < 0.042) and number of hospitalizations (pFWE< 0.032) were associated with decreased FA and increased MD and RD in the bilateral SLF. A trend was found for the BDI-score (pFWE > 0.067). When analyzed simultaneously only the effect of course of illness remained significant (pFWE < 0.040) mapping to the right SLF. Conclusions: Decreased FA and increased MD and RD values in the SLF are associated with more hospitalizations when controlling for current psychopathology. SLF fiber integrity could reflect cumulative illness burden at a neurobiological level and should be targeted in future longitudinal analyses. [ABSTRACT FROM AUTHOR]

Published
2022
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6. White matter fiber microstructure is associated with prior hospitalizations rather than acute symptomatology in major depressive disorder

Author

Meinert, Susanne, primary, Leehr, Elisabeth J., additional, Grotegerd, Dominik, additional, Repple, Jonathan, additional, Förster, Katharina, additional, Winter, Nils R., additional, Enneking, Verena, additional, Fingas, Stella M., additional, Lemke, Hannah, additional, Waltemate, Lena, additional, Stein, Frederike, additional, Brosch, Katharina, additional, Schmitt, Simon, additional, Meller, Tina, additional, Linge, Anna, additional, Krug, Axel, additional, Nenadić, Igor, additional, Jansen, Andreas, additional, Hahn, Tim, additional, Redlich, Ronny, additional, Opel, Nils, additional, Schubotz, Ricarda I., additional, Baune, Bernhard T., additional, Kircher, Tilo, additional, and Dannlowski, Udo, additional

Published
2020
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7. Severity of current depression and remission status are associated with structural connectome alterations in major depressive disorder

Author

Repple, Jonathan, primary, Mauritz, Marco, additional, Meinert, Susanne, additional, de Lange, Siemon C., additional, Grotegerd, Dominik, additional, Opel, Nils, additional, Redlich, Ronny, additional, Hahn, Tim, additional, Förster, Katharina, additional, Leehr, Elisabeth J., additional, Winter, Nils, additional, Goltermann, Janik, additional, Enneking, Verena, additional, Fingas, Stella M., additional, Lemke, Hannah, additional, Waltemate, Lena, additional, Nenadic, Igor, additional, Krug, Axel, additional, Brosch, Katharina, additional, Schmitt, Simon, additional, Stein, Frederike, additional, Meller, Tina, additional, Jansen, Andreas, additional, Steinsträter, Olaf, additional, Baune, Bernhard T., additional, Kircher, Tilo, additional, Dannlowski, Udo, additional, and van den Heuvel, Martijn P., additional

Published
2019
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8. Association between genetic risk for type 2 diabetes and structural brain connectivity in major depressive disorder

Author

Repple, Jonathan, König, Amelie, de Lange, Siemon C., Opel, Nils, Redlich, Ronny, Meinert, Susanne, Grotegerd, Dominik, Mauritz, Marco, Hahn, Tim, Borgers, Tiana, Leehr, Elisabeth J., Winter, Nils, Goltermann, Janik, Enneking, Verena, Fingas, Stella M., Lemke, Hannah, Waltemate, Lena, Dohm, Katharina, Richter, Maike, Mehler, David M.A., Holstein, Vincent, Gruber, Marius, Nenadic, Igor, Krug, Axel, Brosch, Katharina, Schmitt, Simon, Stein, Frederike, Meller, Tina, Jansen, Andreas, Steinsträter, Olaf, Amare, Azmeraw T., Kircher, Tilo, Baune, Bernhard T., van den Heuvel, Martijn P., and Dannlowski, Udo

Abstract

Major depressive disorder (MDD) and type 2 diabetes (T2D) are known to share clinical comorbidity and to have genetic overlap. Besides their shared genetics, both diseases seem to be associated with alterations in brain structural connectivity and impaired cognitive performance, but little is known about the mechanisms by which genetic risk of T2D might affect brain structure and function and if so, how these effects could contribute to the disease course of MDD.

Published
2021
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