25 results on '"Finelli, Rosa"'
Search Results
2. Vitamin D, parathyroid hormone and cardiovascular risk: the good, the bad and the ugly
- Author
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Pascale, Antonietta V., Finelli, Rosa, Giannotti, Rocco, Visco, Valeria, Fabbricatore, Davide, Matula, Ida, Mazzeo, Pietro, Ragosa, Nicola, Massari, Angelo, Izzo, Raffaele, Coscioni, Enrico, Illario, Maddalena, Ciccarelli, Michele, Trimarco, Bruno, and Iaccarino, Guido
- Published
- 2018
- Full Text
- View/download PDF
3. Serum Uric Acid and Left Ventricular Mass in Essential Hypertension
- Author
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Visco, Valeria, primary, Pascale, Antonietta Valeria, additional, Virtuoso, Nicola, additional, Mongiello, Felice, additional, Cinque, Federico, additional, Gioia, Renato, additional, Finelli, Rosa, additional, Mazzeo, Pietro, additional, Manzi, Maria Virginia, additional, Morisco, Carmine, additional, Rozza, Francesco, additional, Izzo, Raffaele, additional, Cerasuolo, Federica, additional, Ciccarelli, Michele, additional, and Iaccarino, Guido, additional
- Published
- 2020
- Full Text
- View/download PDF
4. We are What We Eat: Impact of Food from Short Supply Chain on Metabolic Syndrome
- Author
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Santulli, Gaetano, primary, Pascale, Valeria, additional, Finelli, Rosa, additional, Visco, Valeria, additional, Giannotti, Rocco, additional, Massari, Angelo, additional, Morisco, Carmine, additional, Ciccarelli, Michele, additional, Illario, Maddalena, additional, Iaccarino, Guido, additional, and Coscioni, Enrico, additional
- Published
- 2019
- Full Text
- View/download PDF
5. Education Company Turns Its Strength Inward To Develop Remote Workforce.
- Author
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Finelli, Rosa
- Subjects
LABOR supply ,CAREER development ,DIVERSITY in the workplace ,VOCATIONAL guidance ,VOCATIONAL interests - Abstract
A personal narrative is presented which explores the author's experience of being part of a team at education company Kaplan who implemented an employee-led virtual conference designed to provide personal and professional growth for employees.
- Published
- 2022
6. L&D: Developing Remote Workforce: Education company turns its strength inward to help employees grow.
- Author
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Finelli, Rosa
- Subjects
DISTANCE education ,EMPLOYEE well-being ,CAREER development ,DIVERSITY in the workplace ,VOCATIONAL interests ,EMPLOYEE training - Abstract
The article discusses that how the learning and development (L&D) team of Kaplan, an education company, looked for ways to keep colleagues connected, engaged, and focused on their personal and professional growth during covid-19 pandemic. Topics discussed include annual employee engagement survey of Kaplan, rules of engagement and instructions for the survey and the learning management system of Kaplan.
- Published
- 2022
7. Larger blood pressure reduction by fixed-dose compared to free dose combination therapy of ace inhibitor and calcium antagonist in hypertensive patients
- Author
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Visco, Valeria, Finelli, Rosa, Pascale, Antonietta Valeria, Giannotti, Rocco, Fabbricatore, Davide, Ragosa, Nicola, Ciccarelli, Michele, and Iaccarino, Guido
- Subjects
ACE Inhibitors ,Blood pressure control ,Hypertension ,Combination therapy ,Calcium antagonist - Abstract
The introduction of fixed combination of ACEi+CCB (Fixed) has significantly increased patients compliance and adherence to therapy. At the moment, however, there are no data suggesting the better control of once-daily fixed (Fixed) over free doses in separate administrations combination therapy in hypertensives. In a population of 39 consecutive outpatient patients referred to the departmental Hypertension clinic of the University Hospital of Salerno Medical School with the first diagnosis of arterial hypertension, we tested the hypothesis that the Fixed achieve a better control of blood pressure than the Free combination. Patients were randomized to either strategy and after 3 months patients underwent a clinical assessment to evaluate the antihypertensive effect. The two groups, matched for anthropometric and clinical parameters, received Amlodipine (5-10 mg/daily) and Perindopril (5-10 mg/daily). Perindopril and Amlodipine doses did not significantly differ between the two groups. After 3 months BP control was improved in both groups and BP targets were similarly reached in both groups (SBP; Fixed: 61.54%; Free 69.23%; n.s. DPB; Fixed: 80.77%; Free 84.62%; n.s.). The reduction in systolic blood pressure was similar in both groups (Fixed:7.64±2.49%; Free: 7.81±4.00%, n.s.), while the reduction of diastolic blood pressure was greater in the Fixed group (Fixed: 14.22±2.03%; Free: 4.92±5.00%, p
- Published
- 2017
- Full Text
- View/download PDF
8. Cardiac eccentric remodeling in patients with rheumatoid arthritis
- Author
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Pascale, Valeria, primary, Finelli, Rosa, additional, Giannotti, Rocco, additional, Coscioni, Enrico, additional, Izzo, Raffaele, additional, Rozza, Francesco, additional, Caputo, Dario, additional, Moscato, Paolo, additional, Iaccarino, Guido, additional, and Ciccarelli, Michele, additional
- Published
- 2018
- Full Text
- View/download PDF
9. Abstract P197: Vitamin D, Paratohormone and Cardiovascular Risk: The Good, the Bad and the Ugly
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Giannotti, Rocco, primary, Pascale, Valeria, additional, Finelli, Rosa, additional, Visco, Valeria, additional, Matula, Ida, additional, Ragosa, Nicola, additional, massari, Angelo, additional, Di Sevo, Maria G, additional, Ciccarelli, Michele, additional, and Iaccarino, Guido, additional
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- 2017
- Full Text
- View/download PDF
10. Tackling Cardiovascular Risk: New Evidence from Personalized Medicine
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Finelli, Rosa, primary, Pascale, Antonietta V., additional, Marotta, Paola, additional, Guida, Anna, additional, and Ciccarelli, Michele, additional
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- 2017
- Full Text
- View/download PDF
11. Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders
- Author
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Sorriento, Daniela, Pascale, Antonietta Valeria, Finelli, Rosa, Carillo, Anna Lisa, Annunziata, Roberto, Trimarco, Bruno, and Iaccarino, Guido
- Subjects
Article Subject - Abstract
Mitochondria are critical regulator of cell metabolism; thus, mitochondrial dysfunction is associated with many metabolic disorders. Defects in oxidative phosphorylation, ROS production, or mtDNA mutations are the main causes of mitochondrial dysfunction in many pathological conditions such as IR/diabetes, metabolic syndrome, cardiovascular diseases, and cancer. Thus, targeting mitochondria has been proposed as therapeutic approach for these conditions, leading to the development of small molecules to be tested in the clinical scenario. Here we discuss therapeutic interventions to treat mitochondrial dysfunction associated with two major metabolic disorders, metabolic syndrome, and cancer. Finally, novel mechanisms of regulation of mitochondrial function are discussed, which open new scenarios for mitochondria targeting.
- Published
- 2014
- Full Text
- View/download PDF
12. Abstract P124: “Beyond Silos” Model of Homecare Improves Blood Pressure Control in Multimorbid Hypertensive Patients
- Author
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Pascale, Antonietta Valeria, primary, Finelli, Rosa, additional, Giannotti, Rocco, additional, Visco, Valeria, additional, Matula, Ida, additional, Vairo, Giuseppe, additional, Ciccarelli, Michele, additional, Coscioni, Enrico, additional, and Iaccarino, Guido, additional
- Published
- 2016
- Full Text
- View/download PDF
13. A polymorphism within the promoter of the dopamine receptor D1 (DRD1 -48A7G) associates with impaired kidney function in white hypertensive patients
- Author
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Cipolletta, Ersilia, Ciccarelli, Michele, Izzo, Raffaele, Finelli, Rosa, Trimarco, Bruno, and Iaccarino, Guido
- Abstract
Dopamine DRD1 receptor regulates renal function and vascular resistance. It plays a role in the pathogenesis of hypertension in animal models. In humans, the DRD1 gene presents a A-48G polymorphism associated to hypertension in a Japanese population. To explore the role of this polymorphism on blood pressure and renal function in Caucasian hypertensive patients (H), we evaluated the allele frequencies in a populations of 697 H and 100 blood volunteers, and found no difference in the distribution of the alleles between the two groups (AA;AG;GG: 13%;50%;37%; and 12%; 51%;36% respectively). In H, we found a significant difference between AA and GG in serum creatinine (AA: 1.06±.08 mg/dl; GG:0.97±0.02 mg/dl, p
- Published
- 2012
14. Abstract 16382: Length of Food Chain is Crucial in Determining the Impact of Mediterranean Diet on Metabolic Syndrome and Cardiovascular Risk
- Author
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Santulli, Gaetano, Pascale, Valeria, Finelli, Rosa, Visco, Valeria, Coscioni, Enrico, Giannotti, Rocco, Massari, Angelo, Ciccarelli, Michele, and Iaccarino, Guido
- Abstract
Introduction:Substantial evidence has shown that Mediterranean diet can reduce the risk of metabolic syndrome (MS). However, the development of retail distribution has radically changed food supply worldwide. For instance, in the Mediterranean area, industrial retail favors shipments of groceries from regions that are intensive producers of mass food, generating the long supply chain (LSC) of food; on the other hand, short supply chains (SSCs) typically involve local self-producers promoting local markets. To our knowledge, the role of food retail and distribution in the determination of the risk of developing MS has not been studied hitherto.Hypothesis:We hypothesized that food chain length could affect the risk of developing metabolic alterations such as MS in a population accustomed to Mediterranean diet.Methods:We compared the SSC of food, in which aliments are mainly produced in loco, usually with traditional and low-technology methodologies, to the LSC of food. MS was defined using the latest ?Harmonized Criteria? to diagnose MS [CirculationVol.120 (16), Pg.1640]. The study was registered in the ClincalTrial.govdatabase (NCT03305276).Results:We recruited 407 subjects (average age: 56 years; 59% males), all adhering to Mediterranean diet, living in rural or urbanized areas of Southern Italy. The most important source of food in rural areas is represented by locally grown vegetables and meat of courtyard animals (SSC), whereas in metropolitan areas people mainly eat retail food (LSC). The actual dietary habits were confirmed through a validate questionnaire, designed to distinguish SSC and LSC viaa specific score. No significant differences were observed between SSC and LSC groups in terms of common demographic and metabolic parameters. Intriguingly, we found that being on Mediterranean diet with a SSC significantly (p=0.007) reduced the prevalence of MS compared with LSC, a result that was confirmed after correcting for confounding variables.Conclusions:Taken together, our findings show for the first time that the length of food supply chain is an independent predictor of the risk of MS in a population accustomed to Mediterranean diet, supporting the importance of local food environments in the determination of cardiovascular risk.
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- 2019
- Full Text
- View/download PDF
15. Maternal Hypertension is More Often Observed Among Hypertensive Patients, and Associates to SNPs of the X Chromosome
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Guido IACCARINO, Uliano, Federica, Trimarco, Valentina, Izzo, Raffaele, Pagnotta, Stefano, Tremigliozzi, Rosaria, Rivera, Natalia, Luca, Nicola, Marino, Marina, Finelli, Rosa, Tagliamonte, Virginia, Condorelli, Gianluigi, Ceccarelli, Michele, and Trimarco, Bruno
16. Serum Uric Acid and Left Ventricular Mass in Essential Hypertension
- Author
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Valeria Visco, Antonietta Valeria Pascale, Nicola Virtuoso, Felice Mongiello, Federico Cinque, Renato Gioia, Rosa Finelli, Pietro Mazzeo, Maria Virginia Manzi, Carmine Morisco, Francesco Rozza, Raffaele Izzo, Federica Cerasuolo, Michele Ciccarelli, Guido Iaccarino, Visco, Valeria, Pascale, Antonietta Valeria, Virtuoso, Nicola, Mongiello, Felice, Cinque, Federico, Gioia, Renato, Finelli, Rosa, Mazzeo, Pietro, Manzi, Maria Virginia, Morisco, Carmine, Rozza, Francesco, Izzo, Raffaele, Cerasuolo, Federica, Ciccarelli, Michele, and Iaccarino, Guido
- Subjects
lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,hypertension ,Population ,Renal function ,Cardiovascular Medicine ,030204 cardiovascular system & hematology ,left ventricular mass ,Essential hypertension ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,uric acid ,Internal medicine ,medicine ,risk factors ,030212 general & internal medicine ,Hyperuricemia ,education ,Original Research ,education.field_of_study ,business.industry ,medicine.disease ,Blood pressure ,risk factor ,chemistry ,lcsh:RC666-701 ,left ventricular ma ,Hypertension ,Hypertrophy ,Left ventricular mass ,Risk factors ,Uric acid ,Cohort ,Cardiology ,hypertrophy ,Cardiology and Cardiovascular Medicine ,business ,Kidney disease - Abstract
Serum uric acid (sUA) has been associated with cardiovascular risk. Although the recent mechanistic hypothesis poses the basis for the association between sUA and left ventricular mass index (LVMi), the issue remains poorly investigated in a clinical setup. Through a retrospective analysis of the database of the departmental Hypertension Clinic of University Hospital of Salerno Medical School, we identified 177 essential hypertensives (age 60.3 ± 13.3 years; 85 men), free from uric acid-modulating medications and severe chronic kidney disease, and whose sUA values, anthropometric, clinical, and echocardiographic data were available. In the studied cohort, the average duration of hypertension was 8.4 ± 7.1 years. LVMi associated with classical determinants, such as age, blood pressure, and kidney function, although after multivariate correction, only age remained significant. Also, sUA correlated positively with LVMi, as well as body size, metabolism, and kidney function. In a multivariate analysis, sUA confirmed the independent association with LVMi. Also, levels of sUA >5.6 mg/dl are associated with larger cardiac size. We confirmed our data in a replicate analysis performed in a larger population (1,379 hypertensives) from an independent clinic. Our results demonstrate that sUA increases with LVMi, and a cutoff of 5.6 mg/dl predict larger LV sizes. Our data suggest that hyperuricemia might help to stratify the risk of larger cardiac size in hypertensives.
- Published
- 2020
17. We are What We Eat: Impact of Food from Short Supply Chain on Metabolic Syndrome
- Author
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Rocco Giannotti, Gaetano Santulli, Michele Ciccarelli, Enrico Coscioni, Rosa Finelli, Carmine Morisco, Valeria Visco, Guido Iaccarino, Angelo Massari, Maddalena Illario, Valeria Pascale, Santulli, Gaetano, Pascale, Valeria, Finelli, Rosa, Visco, Valeria, Giannotti, Rocco, Massari, Angelo, Morisco, Carmine, Ciccarelli, Michele, Illario, Maddalena, Iaccarino, Guido, and Coscioni, Enrico
- Subjects
cardiovascular risk ,Mediterranean diet ,Supply chain ,Population ,Retail distribution ,Distribution (economics) ,mediterranean diet ,supply chain of food ,metabolic syndrome ,food retail ,030204 cardiovascular system & hematology ,Article ,03 medical and health sciences ,Food chain ,0302 clinical medicine ,Food supply ,Environmental health ,Medicine ,030212 general & internal medicine ,education ,2. Zero hunger ,education.field_of_study ,business.industry ,General Medicine ,medicine.disease ,Metabolic syndrome ,business - Abstract
Food supply in the Mediterranean area has been recently modified by big retail distribution; for instance, industrial retail has favored shipments of groceries from regions that are intensive producers of mass food, generating a long supply chain (LSC) of food that opposes short supply chains (SSCs) that promote local food markets. However, the actual functional role of food retail and distribution in the determination of the risk of developing metabolic syndrome (MetS) has not been studied hitherto. The main aim of this study was to test the effects of food chain length on the prevalence of MetS in a population accustomed to the Mediterranean diet. We conducted an observational study in Southern Italy on individuals adhering to the Mediterranean diet. We examined a total of 407 subjects (41% females) with an average age of 56 ± 14.5 years (as standard deviation) and found that being on the Mediterranean diet with a SSC significantly reduces the prevalence of MetS compared with the LSC (SSC: 19.65%, LSC: 31.46%; p: 0.007). Our data indicate for the first time that the length of food supply chain plays a key role in determining the risk of MetS in a population adhering to the Mediterranean diet.
- Published
- 2019
18. Vitamin D, parathyroid hormone and cardiovascular risk: The good, the bad and the ugly
- Author
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Raffaele Izzo, Rosa Finelli, Guido Iaccarino, Enrico Coscioni, Ida Matula, Antonietta Valeria Pascale, Nicola Ragosa, Bruno Trimarco, Pietro Mazzeo, Michele Ciccarelli, Maddalena Illario, Angelo Massari, Valeria Visco, Davide Fabbricatore, Rocco Giannotti, Pascale, Antonietta V., Finelli, Rosa, Giannotti, Rocco, Visco, Valeria, Fabbricatore, Davide, Matula, Ida, Mazzeo, Pietro, Ragosa, Nicola, Massari, Angelo, Izzo, Raffaele, Coscioni, Enrico, Illario, Maddalena, Ciccarelli, Michele, Trimarco, Bruno, and Iaccarino, Guido
- Subjects
Male ,Percentile ,25-hydroxyvitamin D cholecalciferol ,aging ,blood pressure ,cardiovascular events ,cardiovascular risk ,Cardiology and Cardiovascular Medicine ,Parathyroid hormone ,030204 cardiovascular system & hematology ,0302 clinical medicine ,Risk Factors ,030212 general & internal medicine ,Young adult ,Vitamin D ,Research Articles ,Aged, 80 and over ,education.field_of_study ,Framingham Risk Score ,Age Factors ,General Medicine ,Middle Aged ,cardiovascular event ,Italy ,Cardiovascular Diseases ,Parathyroid Hormone ,Female ,Adult ,medicine.medical_specialty ,Adolescent ,Population ,Risk Assessment ,03 medical and health sciences ,Young Adult ,Sex Factors ,Internal medicine ,medicine ,Vitamin D and neurology ,Humans ,education ,Aged ,Population mean ,business.industry ,Vitamin D Deficiency ,Endocrinology ,Blood pressure ,Multivariate Analysis ,Linear Models ,business - Abstract
25-Hydroxyvitamin D insufficiency and increased cardiovascular risk (CVR) association is still debated. The vitamin D (VitD)-dependent parathyroid hormone (PTH) is considered as the possible actuator of VitD effects on CVR. To investigate the association of CVR, PTH and VitD, we carried out blood pressure measurements and blood samples and collected information on dietary habits, anamnestic, clinical and metabolic data of 451 participants in the Salerno area (Southern Italy) during the World Hypertension Day (17 May). CVR was calculated according to the Framingham CVR charts. The overall population mean age was 51.6 ± 0.7 years, and female sex was slightly prevalent (55%). VitD deficiency (
- Published
- 2018
19. Cardiac eccentric remodeling in patients with rheumatoid arthritis
- Author
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Guido Iaccarino, Paolo Moscato, Francesco Rozza, Michele Ciccarelli, Valeria Pascale, Raffaele Izzo, Rosa Finelli, Dario Caputo, Enrico Coscioni, Rocco Giannotti, Pascale, Valeria, Finelli, Rosa, Giannotti, Rocco, Coscioni, Enrico, Izzo, Raffaele, Rozza, Francesco, Caputo, Dario, Moscato, Paolo, Iaccarino, Guido, and Ciccarelli, Michele
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Heart Ventricles ,Population ,lcsh:Medicine ,Arthritis ,030204 cardiovascular system & hematology ,Article ,Anti-Citrullinated Protein Antibodies ,Sudden cardiac death ,Arthritis, Rheumatoid ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Humans ,Eccentric ,lcsh:Science ,Ventricular remodeling ,education ,Aged ,030203 arthritis & rheumatology ,education.field_of_study ,Multidisciplinary ,Ventricular Remodeling ,business.industry ,lcsh:R ,Heart ,Gamma globulin ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Ventricle ,Rheumatoid arthritis ,Cardiology ,Female ,lcsh:Q ,gamma-Globulins ,business - Abstract
It is known that patients with rheumatoid arthritis (RA) have a higher risk of coronary heart disease and sudden cardiac death. Abnormalities in cardiac geometry appear to be involved in the setting of the cardiovascular risk, but it has never been specifically investigated in RA. We enrolled 44 patients with RA compared to 131 subjects without RA (normal, N): The RA aged between 18 and 70 years (mean 48.3 ± 2.1), 25 females, BMI 27.6 ± 0.9; N, of equal age (48.6 ± 1.2, n.s.), included 80 females (BMI 26.7 ± 0.2, ns). Cardiac Ultrasounds showed an increase of the diameter of the left ventricle but not in the septum with reduction of relative wall thickness (RWT) in the RA population compared to N. Relative wall thickness inversely correlates with biochemical parameters of inflammatory response (gamma globulin, p
- Published
- 2018
20. Difficult-to-control hypertension: identification of clinical predictors and use of ICT-based integrated care to facilitate blood pressure control
- Author
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Michele Ciccarelli, Valentina Trimarco, Antonietta Valeria Pascale, Rosa Finelli, Valeria Visco, Maddalena Illario, Pietro Mazzeo, Nicola Ragosa, Guido Iaccarino, Visco, Valeria, Finelli, Rosa, Pascale, Antonietta Valeria, Mazzeo, Pietro, Ragosa, Nicola, Trimarco, Valentina, Illario, Maddalena, Ciccarelli, Michele, and Iaccarino, Guido
- Subjects
Male ,medicine.medical_specialty ,Pilot Projects ,030204 cardiovascular system & hematology ,Article ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Heart rate ,Internal Medicine ,medicine ,Humans ,Telemetry ,030212 general & internal medicine ,Family history ,Antihypertensive Agents ,Oxygen saturation (medicine) ,Aged ,Retrospective Studies ,business.industry ,Delivery of Health Care, Integrated ,Retrospective cohort study ,Middle Aged ,Home Care Services ,Integrated care ,Blood pressure ,Hypertension ,Observational study ,Female ,business ,Patient education - Abstract
Difficult-to-control (DTC) hypertension represents a burden in real life that can be partially solved through identification of the characteristics of clinical patterns and tailoring antihypertensive strategies, including ICT-enabled integrated care (ICT-IC). In the quest for clinical predictors of DTC hypertension, we screened 482 hypertensive patients who were consecutively referred to the departmental hypertension clinic. Following a data quality check, patients were divided into controlled (C, 49.37%) and uncontrolled (UC, 50.63%) groups based on their systolic blood pressure (BP) at follow-up. We then performed statistical analysis on the demographic, clinical, laboratory, and ultrasound data and observed that older age, female sex, higher BP levels, and a family history of hypertension were predictors of DTC hypertension. We then developed a pilot service of ICT-IC, including weekly home visits by nurses and patient education on self-monitoring of BP, heart rate, body weight, and oxygen saturation using 3G-connected devices. Self-monitored data were transmitted to the hospital servers on the electronic chart of the patient for remote assessment by the hospital hypertension specialists. A total of 20 UC patients (M/F = 10/10; age: 72.04 ± 2.17 years) were enrolled to verify the efficacy of BP control without changes in medical treatment. After 1 month of the ICT-IC program, BP was reduced both at the office assessment (systolic BP (SBP): 162.40 ± 2.23 mm Hg, beginning of the program vs. 138.20 ± 4.26 mm Hg at 1 month, p < 0.01) and at home (SBP: 149.83 ± 3.44, beginning of the program vs. 134.16 ± 1.67 mm Hg at 1 month, p < 0.01). We concluded that DTC hypertension can be predicted based on the clinical characteristics at the first visit. For these patients, ICT-IC is a feasible therapeutic strategy to achieve BP control.
- Published
- 2017
21. Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders
- Author
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Bruno Trimarco, Roberto Annunziata, Daniela Sorriento, Guido Iaccarino, Anna Lisa Carillo, Rosa Finelli, Antonietta Valeria Pascale, Sorriento, Daniela, Pascale, Antonietta Valeria, Finelli, Rosa, Carillo, Anna Lisa, Annunziata, Roberto, Trimarco, Bruno, and Iaccarino, Guido
- Subjects
Regulator ,lcsh:Medicine ,Oxidative phosphorylation ,Mitochondrion ,Biology ,Bioinformatics ,lcsh:Technology ,DNA, Mitochondrial ,Oxidative Phosphorylation ,General Biochemistry, Genetics and Molecular Biology ,Therapeutic approach ,medicine ,lcsh:Science ,General Environmental Science ,lcsh:T ,lcsh:R ,Cancer ,General Medicine ,medicine.disease ,Metabolic Disease ,Mitochondria ,Cell biology ,Cell metabolism ,mitochondrial fusion ,Mutation ,lcsh:Q ,Metabolic syndrome ,Reactive Oxygen Species ,Human - Abstract
Mitochondria are critical regulator of cell metabolism; thus, mitochondrial dysfunction is associated with many metabolic disorders. Defects in oxidative phosphorylation, ROS production, or mtDNA mutations are the main causes of mitochondrial dysfunction in many pathological conditions such as IR/diabetes, metabolic syndrome, cardiovascular diseases, and cancer. Thus, targeting mitochondria has been proposed as therapeutic approach for these conditions, leading to the development of small molecules to be tested in the clinical scenario. Here we discuss therapeutic interventions to treat mitochondrial dysfunction associated with two major metabolic disorders, metabolic syndrome, and cancer. Finally, novel mechanisms of regulation of mitochondrial function are discussed, which open new scenarios for mitochondria targeting.
- Published
- 2014
22. To NFκB or not to NFκB: The Dilemma on How to Inhibit a Cancer Cell Fate Regulator
- Author
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Sorriento D, Maddalena Illario, Finelli R, Iaccarino G, Sorriento, Daniela, Illario, Maddalena, Finelli, Rosa, and Iaccarino, Guido
- Subjects
IkB ,transcription factors ,Transcription factors ,cancer ,GRK5 ,IκB ,Review ,Cancer - Abstract
Nuclear factor B (NFB) is a transcription factor that plays an important role in carcinogenesis as well as in the regulation of inflammatory response. NFB is constitutively expressed in tumours where it induces the expression of genes which promote cell proliferation, apoptotic events, angiogenesis, invasion and metastasis. Furthermore, many cancer cells show aberrant or constitutive NFB activation that mediates resistance to chemo- and radio-therapy. Therefore, the inhibition of NFB activity appears a potential therapeutic strategy for cancer treatment. In this review, we focus on the role of NFB in carcinogenesis and summarize actual inhibitors of NFB that could be potential therapeutic target in cancer therapy.
- Published
- 2013
23. Larger Blood Pressure Reduction by Fixed-Dose Compared to Free Dose Combination Therapy of ACE Inhibitor and Calcium Antagonist in Hypertensive Patients.
- Author
-
Visco V, Finelli R, Pascale AV, Giannotti R, Fabbricatore D, Ragosa N, Ciccarelli M, and Iaccarino G
- Abstract
The introduction of fixed combination of ACEi+CCB (Fixed) has significantly increased patients compliance and adherence to therapy. At the moment, however, there are no data suggesting the better control of once-daily fixed (Fixed) over free doses in separate administrations combination therapy in hypertensives. In a population of 39 consecutive outpatient patients referred to the departmental Hypertension clinic of the University Hospital of Salerno Medical School with the first diagnosis of arterial hypertension, we tested the hypothesis that the Fixed achieve a better control of blood pressure than the Free combination. Patients were randomized to either strategy and after 3 months patients underwent a clinical assessment to evaluate the antihypertensive effect. The two groups, matched for anthropometric and clinical parameters, received Amlodipine (5-10 mg/daily) and Perindopril (5-10 mg/daily). Perindopril and Amlodipine doses did not significantly differ between the two groups. After 3 months BP control was improved in both groups and BP targets were similarly reached in both groups (SBP; Fixed: 61.54%; Free 69.23%; n.s. DPB; Fixed: 80.77%; Free 84.62%; n.s.). The reduction in systolic blood pressure was similar in both groups (Fixed:7.64±2.49%; Free: 7.81±4.00%, n.s.), while the reduction of diastolic blood pressure was greater in the Fixed group (Fixed: 14.22±2.03%; Free: 4.92±5.00%, p<0.05). Although both strategies are effective in reducing BP, the use of Fixed dose has an advantage in the reduction of BP. The present study does not allow to identify the mechanisms of this difference, which can be assumed to be due to the pharmacokinetics of the drugs administered in once-daily fixed combination.
- Published
- 2017
24. To NFκB or not to NFκB: The Dilemma on How to Inhibit a Cancer Cell Fate Regulator.
- Author
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Sorriento D, Illario M, Finelli R, and Iaccarino G
- Abstract
Nuclear factor κB (NFκB) is a transcription factor that plays an important role in carcinogenesis as well as in the regulation of inflammatory response. NFκB is constitutively expressed in tumours where it induces the expression of genes which promote cell proliferation, apoptotic events, angiogenesis, invasion and metastasis. Furthermore, many cancer cells show aberrant or constitutive NFκB activation that mediates resistance to chemo- and radio-therapy. Therefore, the inhibition of NFκB activity appears a potential therapeutic strategy for cancer treatment. In this review, we focus on the role of NFκB in carcinogenesis and summarize actual inhibitors of NFκB that could be potential therapeutic target in cancer therapy.
- Published
- 2012
25. A Polymorphism within the Promoter of the Dopamine Receptor D1 (DRD1 -48A/G) Associates with Impaired Kidney Function in White Hypertensive Patients.
- Author
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Cipolletta E, Ciccarelli M, Izzo R, Finelli R, Trimarco B, and Iaccarino G
- Abstract
Dopamine DRD1 receptor regulates renal function and vascular resistance. It plays a role in the pathogenesis of hypertension in animal models. In humans, the DRD1 gene presents a A-48G polymorphism associated to hypertension in a Japanese population. To explore the role of this polymorphism on blood pressure and renal function in Caucasian hypertensive patients (H), we evaluated the allele frequencies in a populations of 697 H and 100 blood volunteers, and found no difference in the distribution of the alleles between the two groups (AA;AG;GG: 13%;50%;37%; and 12%; 51%;36% respectively). In H, we found a significant difference between AA and GG in serum creatinine (AA: 1.06±.08 mg/dl; GG:0.97±0.02 mg/dl, p<0.03). Treatment restored serum creatinine at levels comparable between genotypes (AA: 0.99±0.03 mg/dl; GG: 0.94±0.02 mg/dl, n.s.). To replicate the finding, in a case control study of 8 AA and 7 GG hypertensive patients matched for age, sex and body mass index, in pharmacological wash out for 30 days, we evaluated serum (Creatinine, Na, Uric Acid, Urea) and urinary (volume/24h, protein/24h, creatinine clearance/24h) biochemistry and renal hemodynamic assessed by ultrasound. Once again, the AA group showed higher serum creatinine, Na, Uric acid and urea, reduced creatinine clearance and a higher level of urinary protein excretion. These changes occurred while no differences were observed in diuresis and renal vascular resistances. In conclusions, the DRD1 A-48G polymorphism identifies a class of H that is prone to hypertension related kidney alterations.
- Published
- 2012
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