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Your search keyword '"Finbarr P.M. O'Harte"' showing total 3 results
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3 results on '"Finbarr P.M. O'Harte"'

1. Twice daily oral administration of Palmaria palmata protein hydrolysate reduces food intake in streptozotocin induced diabetic mice, improving glycaemic control and lipid profiles

Author

Christopher M. McLaughlin, Shaun J. Sharkey, Pádraigín Harnedy-Rothwell, Vadivel Parthsarathy, Philip J. Allsopp, Emeir M. McSorley, Richard J. FitzGerald, and Finbarr P.M. O'Harte

Subjects
Streptozotocin induced diabetes, Insulin secretion, Palmaria palmata, Protein hydrolysate, GLP-1, Blood glucose, Nutrition. Foods and food supply, TX341-641
Abstract

This study investigated the antihyperglycaemic effectiveness of an oral Palmaria palmata protein hydrolysate (PPPH), versus metformin, upon metabolic control in streptozotocin (STZ)-induced diabetic mice. Mice were administered PPPH (50 mg/kg bodyweight) or metformin (200 mg/kg bodyweight) by oral gavage twice-daily for 18 days. Blood glucose and plasma insulin were measured every third day. PPPH caused a significant reduction in blood glucose (p

Published
2020
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2. Blue whiting (Micromesistius poutassou) muscle protein hydrolysate with in vitro and in vivo antidiabetic properties

Author

Pádraigín A. Harnedy, Vadivel Parthsarathy, Chris M. McLaughlin, Martina B. O'Keeffe, Philip J. Allsopp, Emeir M. McSorley, Finbarr P.M. O'Harte, and Richard J. FitzGerald

Subjects
Blue whiting, Protein hydrolysate, Antidiabetic, Functional food, Amino acid analysis, Peptide identification, Nutrition. Foods and food supply, TX341-641
Abstract

A blue whiting (Micromesistius poutassou) protein hydrolysate generated using Alcalase 2.4L and Flavourzyme 500L and its simulated gastrointestinal digestion (SGID) sample was assessed for antidiabetic potential in vitro and in vivo. In addition to inhibiting dipeptidyl peptidase-IV (DPP–IV), the hydrolysates mediated insulin and glucagon-like peptide-1 (GLP-1) release from BRIN-BD11 and GLUTag cells, respectively. No significant difference was observed in insulinotropic and DPP-IV inhibitory activity following SGID, while GLP-1 secretion increased significantly (p

Published
2018
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3. Protein hydrolysates from boarfish (Capros aper) and Atlantic salmon (Salmo salar) skin gelatin improve metabolic control in genetically obese diabetic (ob/ob) mice

Author

Vadivel Parthsarathy, Chris M. McLaughlin, Shaun J. Sharkey, Pádraigín A. Harnedy-Rothwell, Ryan A. Lafferty, Philip J. Allsopp, Emeir M. McSorley, Richard J. Fitzgerald, and Finbarr P.M. O’Harte

Abstract

There is increasing interest in dietary protein for management of Type 2 diabetes mellitus (T2DM) and obesity. The effects of twice-daily oral administration of a salmon skin gelatin hydrolysate (SSGH, 50 mg/kg), boarfish protein hydrolysate (BPH, (50 mg/kg), metformin (200 mg/kg), or saline control, were investigated in ob/ob mice. Non-fasting blood glucose was significantly reduced with SSGH (p

Published
2021
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