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5. Corrigendum to “Lung and thymic carcinoids: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up”

Author

Baudin, E., primary, Caplin, M., additional, Garcia-Carbonero, R., additional, Fazio, N., additional, Ferolla, P., additional, Filosso, P.L., additional, Frilling, A., additional, de Herder, W.W., additional, Hörsch, D., additional, Knigge, U., additional, Korse, C.M., additional, Lim, E., additional, Lombard-Bohas, C., additional, Pavel, M., additional, Scoazec, J.Y., additional, Sundin, A., additional, and Berruti, A., additional

Published
2021
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8. Unmet medical needs in pulmonary neuroendocrine (Carcinoid) neoplasms

Author

Baudin, E. Hayes, A.R. Scoazec, J.-Y. Filosso, P.L. Lim, E. Kaltsas, G. Frilling, A. Chen, J. Kos-Kudła, B. Gorbunova, V. Wiedenmann, B. Nieveen Van Dijkum, E. Cwikła, J.B. Falkerby, J. Valle, J.W. Kulke, M.H. Caplin, M.E.

Abstract

Pulmonary carcinoids (PCs) display the common features of all well-differentiated neuroendocrine neoplasms (NEN) and are classified as low- A nd intermediate-grade malignant tumours (i.e., typical and atypical carcinoid, respectively). There is a paucity of randomised studies dedicated to advanced PCs and management principles are drawn from the larger gastroenteropancreatic NEN experience. There is growing evidence that NEN anatomic subgroups have different biology and different responses to treatment and, therefore, should be investigated as separate entities in clinical trials. In this review, we discuss the existing evidence and limitations of tumour classification, diagnostics and staging, prognostication, and treatment in the setting of PC, with focus on unmet medical needs and directions for the future. © 2018 S. Karger AG, Basel. All rights reserved.

Published
2019

9. The Diagnosis of Interstitial Lung Disease: Comparison Between HRTC Appearance and Histological Pattern

Author

Verri, G., primary, Guerrera, F., additional, Lyberis, P., additional, Solidoro, P., additional, Costardi, L., additional, Mercante, L., additional, Limerutti, G., additional, Delsedime, L., additional, Mangiapia, M., additional, Bardessono, M.M., additional, Mattei, A., additional, Filosso, P.L., additional, Ruffini, E., additional, and Albera, C., additional

Published
2019
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10. GR01.02 Surgical Oncology

Author

Filosso, P.L., primary, Ruffini, E., additional, Guerrera, F., additional, Lausi, P., additional, Lyberis, P., additional, and Oliaro, A., additional

Published
2018
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11. P1.16-64 The Histological Predominant Pattern Could Predict Site of Recurrence and Metastasis in Surgically Treated Stage I Adenocarcinoma of the Lung

Author

Guerrera, F., primary, Marchese, V., additional, Lococo, F., additional, Rena, O., additional, Ampollini, L., additional, Vannucci, J., additional, Errico, L., additional, Bertoglio, P., additional, Lausi, P., additional, Ventura, L., additional, Viti, A., additional, Paci, M., additional, Filosso, P.L., additional, Oliaro, A., additional, Casadio, C., additional, Puma, F., additional, Ardissone, F., additional, and Ruffini, E., additional

Published
2018
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13. PUB039 FDG-PET Scanning Has a Limited Role in the Management of Low and Intermediate Grade Neuroendocrine Tumors of Lung

Author

Feczko, A., primary, Cattoni, M., additional, Vallieres, E., additional, Brown, L., additional, Sarkeshik, A., additional, Margaritora, S., additional, Siclliani, A., additional, Filosso, P.L., additional, Guerrera, F., additional, Siclliani, A. Alessandra, additional, Rotolo, N., additional, Farjah, F., additional, Wandell, G., additional, Costas, K., additional, Mann, C., additional, Hubka, M., additional, Kaplan, S., additional, Wilshire, C., additional, Farivar, A., additional, Aye, R., additional, and Louie, B., additional

Published
2017
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14. OA 16.02 Risk of Recurrence in Stage I Adenocarcinoma of the Lung: A Multi-Institutional Study on Interaction with Type of Surgery and Type of Nodal Staging

Author

Guerrera, F., primary, Lococo, F., additional, Evangelista, A., additional, Rena, O., additional, Ampollini, L., additional, Vannucci, J., additional, Ventura, L., additional, Marchese, V., additional, Paci, M., additional, Filosso, P.L., additional, Oliaro, A., additional, Casadio, C., additional, Puma, F., additional, Ardissone, F., additional, and Ruffini, E., additional

Published
2017
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16. F-036EPIDERMAL GROWTH FACTOR RECEPTOR MUTATIONS ARE LINKED TO SKIP N2 LYMPH NODE METASTASIS IN RESECTED NON-SMALL CELL LUNG CANCER ADENOCARCINOMAS

Author

Guerrera, Francesco, primary, Renaud, S., additional, Tabbo, F., additional, Voegeli', A., additional, Filosso, P.L., additional, Legrain, M., additional, Beau-Faller, M., additional, Ruffini, E., additional, Falcoz, P., additional, Inghirami, G., additional, Oliaro, A., additional, and Massard, G., additional

Published
2016
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17. V-013BRONCHO-OESOPHAGEAL FISTULA CAUSED BY FOREIGN BODY

Author

Oliaro, Alberto, primary, Ruffini, E., additional, Filosso, P.L., additional, Lyberis, P., additional, Bora, G., additional, Roffinella, M., additional, Sandri, A., additional, Bruna, M.C., additional, Guerrera, F., additional, Olivetti, S., additional, Nigra, V.A., additional, Costardi, L., additional, and Lanza, G.V., additional

Published
2016
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20. P-175PREDICTIVE VALUE OF 18F-FDG POSITRON EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY SUVmax IN PATIENTS WITH PULMONARY METASTASIS FROM COLORECTAL CANCER UNDERGOING SURGICAL RESECTION

Author

Rena, Ottavio, primary, Guerrera, F., additional, Errico, L., additional, Ruffini, E., additional, Filosso, P.L., additional, Mossetti, C., additional, Papalia, E., additional, Lisi, E., additional, Ardissone, F., additional, Oliaro, A., additional, and Casadio, C., additional

Published
2015
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28. Recurrence of thymoma: Analysis of clinicopathologic features, treatment, and outcome

Author

Ruffini, E., Mancuso, M., Oliaro, A., Casadio, C., Cavallo, A., Cianci, R., Filosso, P.L., Molinatti, M., Porrello, C., Cappello, N., and Maggi, G.

Abstract

Objective and methods: This study reports clinicopathologic features, treatment, and outcome of 30 recurrent thymomas out of 266 totally resected thymomas. Results: The mean disease-free interval to recurrence was 86 months. Recurrence occurred less frequently and after a longer disease-free interval after resection of encapsulated versus invasive thymomas. The presence of associated myasthenia gravis did not affect recurrence proportion, disease-free interval, or survival after recurrence. A local recurrence occurred in 11 patients, 17 patients had a distant recurrence, and the extent of the recurrence could not be determined in 2 cases. Surgical treatment of the recurrent tumor was attempted in 16 cases, and a total resection was possible in 10 cases; exclusive radiotherapy was done in 11 cases. Overall 5- and 10-year survivals were 48% and 24%, respectively. In a univariate analysis, survival was significantly better in the presence of a local recurrence and in case of a total resection of the recurrent tumor. The use of adjuvant therapy after the resection of the initial thymoma had no effect on reducing the incidence of recurrence, in prolonging the disease-free interval, or in improving survival after the development of the recurrence. In a multivariate survival analysis, significant prognostic factors were the presence of a local recurrence and total resection of the recurrent tumor. Conclusions: Surgical resection is recommended in patients with recurrent thymoma. Local recurrence and total resection of the recurrent tumor are associated with excellent prognosis. A poor prognosis may be anticipated in the presence of distant recurrence and when radical surgical treatment is not done. (J Thorac Cardiovasc Surg 1997;113:55-63)

Published
1997
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35. Cell of origin markers identify different prognostic subgroups of lung adenocarcinoma

Author

Giovannino Ciccone, Francesca Maletta, Anna Sapino, Pier Luigi Filosso, Nicola Veronese, Francesco Guerrera, Alberto Oliaro, Fabrizio Tabbò, Marcello Gaudiano, Claudio Luchini, Enrico Ruffini, Giorgio Inghirami, Luisa Delsedime, Licia Montagna, Filomena Di Giacomo, Alessia Nottegar, Aldo Scarpa, Marco Chilosi, Enrica Migliore, Tabbò, F., Nottegar, A., Guerrera, F., Migliore, E., Luchini, C., Maletta, F., Veronese, N., Montagna, L., Gaudiano, M., Di Giacomo, F., Filosso, P.L., Delsedime, L., Ciccone, G., Scarpa, A., Sapino, A., Oliaro, A., Ruffini, E., Inghirami, G., and Chilosi, M.

Subjects
Lung adenocarcinoma, Morphology, Adult, Male, 0301 basic medicine, Oncology, Biomarkers, Genetic mutations, Immunohistochemistry, Survival analysis, Pathology, medicine.medical_specialty, Candidate gene, Cell of origin, six-immunohistochemical markers panel (TTF1, SP-A, Napsin A, MUC5AC, CDX2 and CK5), Adenocarcinoma of Lung, Kaplan-Meier Estimate, genetic mutations, Gene mutation, Biology, medicine.disease_cause, adenocarcinoma (ADC), survival analysis, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, morphology, Biomarkers, Tumor, medicine, Humans, CDX2, Aged, biomarkers, immunohistochemistry, lung adenocarcinoma, Middle Aged, respiratory system, Prognosis, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, Adenocarcinoma, Female, KRAS
Abstract

Strong prognostic markers able to stratify lung adenocarcinoma (ADC) patients are lacking. We evaluated whether a six-immunohistochemical markers panel (TTF1, SP-A, Napsin A, MUC5AC, CDX2 and CK5), defining the putative neoplastic “cell of origin,” allows to identify prognostic subgroups among lung ADC. We screened a large cohort of ADC specimens (2003–2013) from Torino Institutional Repository identifying: (i) marker positivity by immunohistochemistry, (ii) main morphological appearance by light microscopy, (iii) presence of “hotspot” mutations of candidate genes by Sequenom technology. To evaluate possible predictors of survival and time to recurrence, uni- and multivariable-adjusted comparisons were performed. We identified 4 different subgroups: “alveolar,” “bronchiolar,” “mixed” and “null type." Alveolar-differentiated ADC were more common in young (P =.065), female (P =.083) patients, frequently harboring EGFR-mutated (P =.003) tumors with acinar pattern (P

Published
2018

36. The significance of associated pre-invasive lesions in patients resected for primary lung neoplasms

Author

Ruffini, E., Bongiovanni, M., Cavallo, A., Filosso, P.L., Giobbe, R., Mancuso, M., Molinatti, M., and Oliaro, A.

Subjects
*TUMORS, *NEUROENDOCRINE tumors, *HYPERPLASIA, *LOGISTIC regression analysis
Abstract

Objective: To evaluate the prevalence and clinico/prognostic significance of the presence of pre-invasive lesions in patients resected for primary lung neoplasm. Methods: From 1993 to 2002, 1090 patients received resection for primary lung carcinomas. Of these, 73 presented an associated pre-invasive lesion in the surgical specimen distant from the primary tumour. Classification of pre-invasive lesions included Atypical Adenomatous Hyperplasia (AAH); Carcinoma In Situ (CIS) either diffuse or at the bronchial resection margin; Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH). Correlation between the presence of pre-invasive lesion and the following variables were calculated by logistic regression analysis: sex, age, median tumour size, histology, histologic differentiation, histologic evidence of invasiveness (vascular and perineural invasion), peritumoural lymphocytic infiltrate, pTNM, lobe location, history of previous malignancy. Survival rates were computed using Kaplan–Meier method and survival differences with the total patient population of resected lung carcinomas were tested using the log-rank method. Results: There were 28 AAH, 42 CIS (5 at the bronchial resection margin) and 3 DIPNECH. Histology of the primary tumor included bronchioloalveolar carcinoma (9 patients), adenocarcinoma (19), squamous cell carcinoma (39), typical carcinoid tumour (3) and adenosquamous carcinoma (3). Overall prevalence of pre-invasive lesion was 6.7%. A strong correlation was found between the presence of AAH and the co-existence of either adenocarcinoma, bronchioloalveolar carcinoma or mixed adenocarcinoma-containing tumours (P=0.00002); between CIS and squamous cell carcinoma (P=0.009) and between DIPNECH and carcinoid tumours (P=0.0001). No significant correlation was found between the presence of any type of pre-invasive lesion and sex, age, median tumour size, histologic differentiation, histologic evidence of invasiveness, pTNM, lobe location and history of previous malignancy or the probability to develop a second primary lung carcinoma in the remaining lobe(s) after resection. Survival rates in the patients with AAH and CIS were not significantly different from those of patients without pre-invasive lesion (P=0.3 and P=0.1). Conclusions: Associated pre-invasive lesions in patients resected for primary lung neoplasms are not infrequent. AAH is associated with adenocarcinoma, CIS with squamous cell carcinoma, DIPNECH with typical carcinoid tumours. Our experience indicates that in these patients histology, stage distribution and survival do not differ from the total population of resected patients with lung tumors. [Copyright &y& Elsevier]

Published
2004
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