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1. No evidence of pathogenicity of Dientamoeba fragilis following detection in stools: A case-control study

Author

Tchamwa Bamini Germain, Charpentier Eléna, Guemas Emilie, Chauvin Pamela, Fillaux Judith, Valentin Alexis, Cassaing Sophie, Ménard Sandie, Berry Antoine, and Iriart Xavier

Subjects
dientamoeba fragilis, pathogenicity, stools, blastocystis sp., Infectious and parasitic diseases, RC109-216
Abstract

Dientamoeba fragilis is a ubiquitous intestinal parasite with detection in the stools that has become increasingly frequent following the advent of PCR as a routine screening tool. However, the pathogenicity of this parasite is still much debated. In order to assess the potentially pathogenic nature of this protozoan, a retrospective case-control study was carried out between January and December 2020 on patients from Toulouse University Hospital, with the aim of evaluating the potential clinical effects and changes in laboratory parameters linked to the presence and load of D. fragilis in stools. After matching age, sex and mode of care (consultation or hospitalisation), no significant difference was observed in the frequency of clinical signs between the 36 patients who tested positive for Dientamoeba fragilis PCR in their stools and the 72 control patients who were PCR negative for this protozoan. The presence of D. fragilis in the faeces was not associated with changes in laboratory parameters. Furthermore, a high digestive load of D. fragilis had no identifiable impact on clinical and laboratory parameters. Only the concomitant presence of Blastocystis sp. in stools was significantly more frequent in the D. fragilis group (uni- and multivariate analysis). Finally, this study showed no significant difference in clinical or laboratory signs between patients carrying Dientamoeba fragilis and the control group, regardless of the intestinal parasite load, suggesting that D. fragilis could be considered a commensal of the digestive tract.

Published
2024
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3. Evaluation of the Performance of the Novodiag® Stool Parasites Assay for the Detection of Intestinal Protozoa and Microsporidia

Author

Chauvin, Pamela, primary, Barba, Florie, additional, Guemas, Emilie, additional, Charpentier, Eléna, additional, Cottrel, Claire, additional, Fillaux, Judith, additional, Valentin, Alexis, additional, Baklouti, Sarah, additional, Cassaing, Sophie, additional, Ménard, Sandie, additional, Berry, Antoine, additional, and Iriart, Xavier, additional

Published
2023
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5. Fatal mucormycosis and aspergillosis coinfection associated with haemophagocytic lymphohistiocytosis: A case report and literature review

Author

Loubet, Dorian, primary, Sarton, Benjamine, additional, Lelièvre, Lucie, additional, Grouteau, Gaspard, additional, Iriart, Xavier, additional, Chauvin, Pamela, additional, Fillaux, Judith, additional, Valentin, Alexis, additional, Berry, Antoine, additional, Silva, Stein, additional, Bonneville, Fabrice, additional, Cassaing, Sophie, additional, and Guemas, Emilie, additional

Published
2023
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6. Evaluation of the Performance of the Novodiag ® Stool Parasites Assay for the Detection of Intestinal Protozoa and Microsporidia.

Author

Chauvin, Pamela, Barba, Florie, Guemas, Emilie, Charpentier, Eléna, Cottrel, Claire, Fillaux, Judith, Valentin, Alexis, Baklouti, Sarah, Cassaing, Sophie, Ménard, Sandie, Berry, Antoine, and Iriart, Xavier

Subjects
INTESTINAL parasites, MICROSPORIDIA, MICROSPORIDIOSIS, PROTOZOA, PATHOGENIC protozoa, PARASITES
Abstract

Objectives: We aimed to assess the performance of the Novodiag® Stool Parasites (NSP) assay in the diagnosis of the most common intestinal protozoan and microsporidia infections. Methods: A panel of 167 selected stool samples was retrospectively analysed with the NSP assay and compared to routine microscopy and qPCR methods for the detection of pathogenic protozoa and microsporidia. Results: Whereas specificity was high for all protozoa and microsporidia, NSP sensitivity was strongly dependent on the comparative method used as reference. When compared to microscopic methods, NSP sensitivity was high (96.7 to 100%) for Blastocystis hominis, Entamoeba histolytica and Cyclospora cayetanensis but was lower for Giardia intestinalis (85.2%) and ≤50% for Cystoisospora belli and Dientamoeba fragilis. In comparison to conventional qPCR, the NSP assay demonstrated lower sensitivity characteristics dependent on parasite loads, reaching 60 to 70% for G. intestinalis, D. fragilis, Cryptosporidium spp. and E. histolytica. Sensitivity was 100% for Enterocytozoon bieneusi, but none of the five samples containing Encephalitozoon spp. were detected. Conclusions: The overall performance of the NSP assay in the diagnosis of gastrointestinal protozoa and microsporidia seems to be better than or equivalent to that observed with microscopic methods but inferior to that obtainable with classical targeted qPCR. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Human toxocariasis and atopy

Author

Magnaval Jean-François, Fillaux Judith, Cassaing Sophie, Valentin Alexis, Iriart Xavier, and Berry Antoine

Subjects
human toxocariasis, atopy, outcome, clinical picture, eosinophilia, ige, Infectious and parasitic diseases, RC109-216
Abstract

To assess the possible influence of atopy on the clinical picture of human toxocariasis, a retrospective study was carried out using file records for patients who attended the Outpatient Clinic of Parasitology in Toulouse University Hospitals. A total of 106 file records for patients who had been diagnosed with common/covert toxocariasis were extracted from the database. Forty-nine patients (20 females and 29 males) were considered atopic since they exhibited a long (≥ 1 year) history of various allergic issues along with a titer ≥ 0.7 kIU/L for specific IgE against at least two out of nine mixes of common inhalant allergens. Fifty-seven patients (42 females and 15 males) were designated nonatopic on the basis of a negative result (

Published
2020
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8. Serological diagnosis of Toxoplasma gondii: analysis of false-positive IgG results and implications

Author

Simon Loïc, Fillaux Judith, Guigon Aurélie, Lavergne Rose-Anne, Villard Odile, Villena Isabelle, Marty Pierre, and Pomares Christelle

Subjects
toxoplasma gondii, igg, false-positive, serology, architect, toxoplasmosis, Infectious and parasitic diseases, RC109-216
Abstract

Background: Primary infection by Toxoplasma gondii in pregnant women can result in serious outcomes for the foetus. A false-positive IgG result during pregnancy can lead to a misdiagnosis of past infection and to stopping preventive measures. We collected 189 sera with positive Architect® Toxo IgG assay (Abbott Laboratories) and negative IgG results with at least two other serological tests, in order to find an explanation for the suspected false-positive IgG results. We used the recomLine Toxoplasma IgG® immunoblot (Mikrogen Diagnostik) to search for specific antigenic reactivities of the sera, and the LDBio Toxo II IgG® immunoblot (LDBio Diagnostics) as a confirmatory test. Results: The bands GRA8 and/or GRA7 were positive for 148 samples (78.3%). GRA8 was the most frequent band, appearing in 133 patterns (70.4%), whereas GRA7 was present for 49 samples (25.9%). Of the 81 samples tested with LDBio®, 23 (28.4%) turned out to be positive. Of the 58 negative LDBio® tests (71.6%) (real false-positive Architect® IgG), 23 samples (39.6%) did not show either a GRA8 or p30 band by recomLine®. Their false positivity with Architect® remains unexplained since Abbott uses these two recombinant antigens for their assay. Conclusions: The Architect® IgG false positivity for T. gondii seems to be due to reactivity against GRA8 for the majority of the sera and GRA7 to a lesser extent. The hypothesis of past contact with parasites genetically close to T. gondii such as Hammondia hammondi or Neospora caninum seems promising and should be assessed further.

Published
2020
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11. Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018)

Author

Bretagne, Stéphane, Sitbon, Karine, Desnos-Ollivier, Marie, Garcia-Hermoso, Dea, Letscher-Bru, Valérie, Cassaing, Sophie, Millon, Laurence, Morio, Florent, Gangneux, Jean-Pierre, Hasseine, Lilia, Favennec, Loïc, Cateau, Estelle, Bailly, Eric, Moniot, Maxime, Bonhomme, Julie, Desbois-Nogard, Nicole, Chouaki, Taieb, Paugam, André, Bouteille, Bernard, Pihet, Marc, Dalle, Frédéric, Eloy, Odile, Sasso, Milène, Demar, Magalie, Mariani-Kurkdjian, Patricia, Robert, Vincent, Lortholary, Olivier, Dromer, Françoise, French Mycoses Study Group, The, Damiani, Céline, Dupont, Hervé, Maizel, Julien, Totet, Anne, Bouchara, Jean-Philippe, Bellanger, Anne Pauline, Berceanu, Ana, Navellou, Jean Christophe, Scherer, Emeline, Abboud, Philippe, Aznar, Christine, Blanchet, Denis, Djossou, Félix, Cayot, Sophie, Garrouste, Cyril, Lesens, Olivier, Moluçon, Cécile, Nourrisson, Céline, Poirier, Philippe, Bailly, Éloïse, Basmaciyan, Louise, Belaid, Bouhemad, Blot, Mathieu, Caillot, Denis, Charles, Pierre-Emmanuel, Quenot, Jean Pierre, Amazan, Emmanuelle, Baubion, Emilie, Cabie, André, Chabartier, Cyrille, Deligny, Christophe, Emal, Violaine, Flechelle, Olivier, Hatchuel, Yves, Le Govic, Yohann, Merle, Harold, Miossec, Charline, Turmel, Jean-Marie, Valentino, Ruddy, Durieux, Marie-Fleur, Turlure, Pascal, Mercier, Victor, Gari-Toussaint, Martine, Risso, Karine, Simon, Loïc, Bretonnière, Cedric, Boutoille, David, Gastinne, Thomas, Lakhal, Karim, Launay, Elise, Lepoivre, Thierry, Peterlin, Pierre, Rialland, Fanny, Le Pape, Patrice, Canoui, Etienne, Dahane, Naima, Kerneis, Solène, Angebault, Cécile, Bougnoux, Marie-Elisabethh, Guennouni, Nadia, Lanternier, Fanny, Neven, Bennedicte, Oualha, Mehdi, Scemla, Anne, Sitterlé, Emilie, Suarez, Felipe, Toubiana, Julie, Bonacorci, Stéphane, Alanio, Alexandre, Bergeron, Anne, Denis, Blandine, Gits-Muselli, Maud, Hamane, Samia, Touratier, Sophie, Chaumeil, Christine, Merabet, Lilia, Claudéon, Joelle, Curlier, Elodie, Galantine, Valérie, Gallois, Jean Claude, Markowicz, Samuel, Nicolas, Muriel, Musson, Pascal, Schepers, Kinda, Minoza, Alida, Kauffmann-Lacroix, Catherine, Guégan, Hélène, Costa, Damien, Dehais, Marion, Gargala, Gilles, Bajolet, Odile, Banisadr, Firouze, Cousson, Joel, Himberlin, Chantal, Huguenin, Antoine, Toubas, Dominique, Flori, Pierre, Mahinc, Caroline, Raberin, Hélène, Denis, Julie, Herbrecht, Raoul, Mertes, Paul-Michel, Meziani, Fehrat, Sabou, Marcela, Schneider, Francis, Bertozzi, Anne-Isabelle, Chauvin, Pamela, Charpentier, Elena, Cointault, Olivier, Cottrel, Claire, Delavigne, Karen, Faguer, Stanislas, Fillaux, Judith, Guemas, Emilie, Iriart, Xavier, Lelièvre, Lucie, Ruiz, Jean, Bastides, Frédéric, Chesnay, Adélaïde, Desoubeaux, Guillaume, Therby, Audrey, Chachaty, Elisabeth, Gachot, Bertrand, Westerdijk Fungal Biodiversity Institute, Westerdijk Fungal Biodiversity Institute - Software and Databasing, Mycologie moléculaire - Molecular Mycology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals (CNRMA), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Dynamique des interactions hôte pathogène (DIHP), Université de Strasbourg (UNISTRA), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Nantes Université (Nantes Univ), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Hospitalier Universitaire de Nice (CHU Nice), CHU Rouen, Normandie Université (NU), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Ecologie et biologie des interactions (EBI), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), CHU Clermont-Ferrand, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), CHU de la Martinique [Fort de France], CHU Amiens-Picardie, Hôpital Cochin [AP-HP], CHU Limoges, SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques (ICAT), Université d'Angers (UA), Laboratoire de Parasitologie-Mycologie (CHU d'Angers), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Infections Respiratoires Fongiques (IRF), Université d'Angers (UA)-Université de Brest (UBO), Procédés Alimentaires et Microbiologiques [Dijon] (PAM), Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Centre Hospitalier de Versailles André Mignot (CHV), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Hôpital Robert Debré Paris, Hôpital Robert Debré, Westerdijk Fungal Biodiversity Institute [Utrecht] (WI), Royal Netherlands Academy of Arts and Sciences (KNAW), Service des Maladies infectieuses et tropicales [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 (AGIR ), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Simplification des soins chez les patients complexes - UR UPJV 7518 (SSPC), Université de Picardie Jules Verne (UPJV), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Laboratoire de Parasitologie-Mycologie [CHU Angers], Hôpital Bretonneau, Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by recurrent financial support from Santé Publique France and Institut Pasteur. The funders had no role in study design, data collection, analysis, interpretation of data, or the decision to submit the work for publication., We thank Didier Che (Direction des Maladies Infectieuses, Santé Publique France) for his continuous support and interest in invasive fungal infections and Etienne Sevin (EpiConcept, Paris, France) for his contribution in the development of the RESSIF website using the VOOZANOO platform. We are thankful for the technical help of Catherine Blanc, Anne Boullié, Cécile Gautier, Virginie Geolier, and Damien Hoinard (Institut Pasteur) for the characterization of the isolates received at the NRCMA., The French Mycoses Study Group includes collaborators who contributed to these data by their involvement in the management of patients, expertise in diagnostic tools, and/or characterization of fungal isolates. They are listed in alphabetical order of a city in France and for each center, in alphabetical order of the last names: in Amiens, Céline Damiani, Hervé Dupont, Julien Maizel, and Anne Totet, in Angers, Jean-Philippe Bouchara, in Besançon, Anne Pauline Bellanger, Ana Berceanu, Jean Christophe Navellou, and Emeline Scherer, in Cayenne, Philippe Abboud, Christine Aznar, Denis Blanchet, and Félix Djossou, in Clermont-Ferrand, Sophie Cayot, Cyril Garrouste, Olivier Lesens, Cécile Moluçon, Céline Nourrisson, and Philippe Poirier, in Dijon, Éloïse Bailly, Louise Basmaciyan, Bouhemad Belaid, Mathieu Blot, Denis Caillot, Pierre-Emmanuel Charles, and Jean Pierre Quenot, in Fort de France, Emmanuelle Amazan, Emilie Baubion, André Cabie, Cyrille Chabartier, Christophe Deligny, Violaine Emal, Olivier Flechelle, Yves Hatchuel, Yohann Le Govic, Harold Merle, Charline Miossec, Jean-Marie Turmel, and Ruddy Valentino, in Limoges, Marie-Fleur Durieux and Pascal Turlure, in Nîmes, Victor Mercier, in Nice, Martine Gari-Toussaint, Karine Risso, and Loïc Simon, in Nantes, Cedric Bretonnière, David Boutoille, Thomas Gastinne, Karim Lakhal, Elise Launay, Thierry Lepoivre, Pierre Peterlin, Fanny Rialland, and Patrice Le Pape, in Paris, in Hôpital Cochin, Etienne Canoui, Naima Dahane, and Solène Kerneis, in Hôpital Necker-Enfants Malades, Cécile Angebault, Marie-Elisabethh Bougnoux, Nadia Guennouni, Fanny Lanternier, Bennedicte Neven, Mehdi Oualha, Anne Scemla, Emilie Sitterlé, Felipe Suarez, and Julie Toubiana, in Hôpital Robert-Debré, Stéphane Bonacorci, in Hôpital Saint-Louis, Alexandre Alanio, Anne Bergeron, Blandine Denis, Maud Gits-Muselli, Samia Hamane, and Sophie Touratier, in hôpital des XV-XX, Christine Chaumeil and Lilia Merabet, in Pointe-à-Pitre, Joelle Claudéon, Elodie Curlier, Valérie Galantine, Jean Claude Gallois, Samuel Markowicz, Muriel Nicolas, Pascal Musson, and Kinda Schepers, in Poitiers, Alida Minoza and Catherine Kauffmann-Lacroix, in Rennes, Hélène Guégan, in Rouen, Damien Costa, Marion Dehais, and Gilles Gargala, in Reims, Odile Bajolet, Firouze Banisadr, Joel Cousson, Chantal Himberlin, Antoine Huguenin, and Dominique Toubas, in Saint Etienne, Pierre Flori, Caroline Mahinc, and Hélène Raberin, in Strabourg, Julie Denis, Raoul Herbrecht, Paul-Michel Mertes, Fehrat Meziani, Marcela Sabou, and Francis Schneider, in Toulouse, Anne-Isabelle Bertozzi, Pamela Chauvin, Elena Charpentier, Olivier Cointault, Claire Cottrel, Karen Delavigne, Stanislas Faguer, Judith Fillaux, Emilie Guemas, Xavier Iriart, Lucie Lelièvre, and Jean Ruiz, in Tours, Frédéric Bastides, Adélaïde Chesnay, and Guillaume Desoubeaux, in Versailles, Audrey Therby, and in Villejuif, Elisabeth Chachaty and Bertrand Gachot., and CLEMENT, Nathalie

Subjects
Antifungal Agents, pneumocytosis, invasive fungal infections, Pneumonia, Pneumocystis, [SDV]Life Sciences [q-bio], candidemia, Microbiology, [SDV.MP.MYC] Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, mucormycosis, [SDV] Life Sciences [q-bio], [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Virology, Humans, aspergillosis, epidemiology, Watchful Waiting, Fungemia, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, Aged
Abstract

International audience; The French National Reference Center for Invasive Mycoses and Antifungals leads an active and sustained nationwide surveillance program on probable and proven invasive fungal diseases (IFDs) to determine their epidemiology in France. Between 2012 and 2018, a total of 10,886 IFDs were recorded. The incidence increased slightly over time (2.16 to 2.36/10,000 hospitalization days, P = 0.0562) in relation with an increase of fungemia incidence (1.03 to 1.19/10,000, P = 0.0023), while that of other IFDs remained stable. The proportion of ≥65-year-old patients increased from 38.4% to 45.3% (P < 0.0001). Yeast fungemia (n = 5,444) was due mainly to Candida albicans (55.6%) with stable proportions of species over time. Echinocandins became the main drug prescribed (46.7% to 61.8%), but global mortality rate remained unchanged (36.3% at 1 month). Pneumocystis jirovecii pneumonia (n = 2,106) was diagnosed mostly in HIV-negative patients (80.7%) with a significantly higher mortality than in HIV-positive patients (21.9% versus 5.4% at 1 month, P < 0.0001). Invasive aspergillosis (n = 1,661) and mucormycosis (n = 314) were diagnosed mostly in hematology (>60% of the cases) with a global mortality rate of 42.5% and 59.3%, respectively, at 3 months and significant changes in diagnosis procedure over time. More concurrent infections were also diagnosed over time (from 5.4% to 9.4% for mold IFDs, P = 0.0115). In conclusion, we observed an aging of patients with IFD with a significant increase in incidence only for yeast fungemia, a trend toward more concurrent infections, which raises diagnostic and therapeutic issues. Overall, global survival associated with IFDs has not improved despite updated guidelines and new diagnostic tools.IMPORTANCE The epidemiology of invasive fungal diseases (IFDs) is hard to delineate given the difficulties in ascertaining the diagnosis that is often based on the confrontation of clinical and microbiological criteria. The present report underlines the interest of active surveillance involving mycologists and clinicians to describe the global incidence and that of the main IFDs. Globally, although the incidence of Pneumocystis pneumonia, invasive aspergillosis, and mucormycosis remained stable over the study period (2012 to 2018), that of yeast fungemia increased slightly. We also show here that IFDs seem to affect older people more frequently. The most worrisome observation is the lack of improvement in the global survival rate associated with IFDs despite the increasing use of more sensitive diagnostic tools, the availability of new antifungal drugs very active in clinical trials, and a still low/marginal rate of acquired in vitro resistance in France. Therefore, other tracks of improvement should be investigated actively.

Published
2022

12. Performance of seven commercial automated assays for the detection of low levels of anti-Toxoplasma IgG in French immunocompromised patients

Author

Douet Tiphaine, Armengol Catherine, Charpentier Elena, Chauvin Pamela, Cassaing Sophie, Iriart Xavier, Berry Antoine, and Fillaux Judith

Subjects
toxoplasma gondii, igg low level, immunodiagnosis, automated tests, Infectious and parasitic diseases, RC109-216
Abstract

Background: Immunocompromised patients are at high risk for the development of severe toxoplasmosis from tissue cyst reactivation, the most frequently, or from recently acquired acute infections. Knowledge of serologic status is therefore crucial. Screening for toxoplasmosis is sometimes performed while patients are already immunocompromised and have a low or even undetectable IgG titer by routine automated enzyme immunoassays. The aim of this study was to assess the sensitivity and specificity of seven reagents for the detection of low levels of IgG. Sera from 354 patients were collected and analysed. Results: Elecsys® offered the best analytic performances, superior to those of Architect® and Platelia®, which were superior to those of Access II® and TGS TA®. Vidas II® and Liaison II® reagents exhibited poor analytical performances in this cohort. For Elecsys®, Platelia® and Architect®, new thresholds for the grey zone and positive zone have been defined to improve the sensitivity of these reagents while maintaining excellent specificity. Conclusions: Commercialized assays for toxoplasmosis screening are not suitable for IgG low-level detection in patients without adapting the supplier thresholds to avoid false negative results and risk generalized toxoplasmosis.

Published
2019
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17. Alveolar and Blood T Lymphocyte Profiles in Pneumocystis jirovecii-Positive Patients: Effects of HIV Status

Author

Iriart, Xavier, Witkowski, Benoit, Cassaing, Sophie, Abbes, Sarah, Menard, Sandie, Fillaux, Judith, Valentin, Alexis, Linas, Marie-Denise, Tkaczuk, Jean, Huget, Françoise, Huynh, Anne, Hermant, Christophe, Escamilla, Roger, Kamar, Nassim, Cointault, Olivier, Lavayssiere, Laurence, Alvarez, Muriel, Blancher, Antoine, Marchou, Bruno, Magnaval, Jean-François, and Berry, Antoine

Published
2011
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21. New Insights into Blood Circulating Lymphocytes in Human Pneumocystis Pneumonia

Author

Charpentier, Eléna, primary, Marques, Catherine, additional, Ménard, Sandie, additional, Chauvin, Pamela, additional, Guemas, Emilie, additional, Cottrel, Claire, additional, Cassaing, Sophie, additional, Fillaux, Judith, additional, Valentin, Alexis, additional, Blanchard, Nicolas, additional, Berry, Antoine, additional, and Iriart, Xavier, additional

Published
2021
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24. Schistosomiasis haematobium, Corsica, France

Author

Berry, Antoine, Mone, Helene, Iriart, Xavier, Mouahid, Gabriel, Aboo, Olivier, Boissier, Jerome, Fillaux, Judith, Cassaing, Sophie, Debuisson, Cecile, Valentin, Alexis, Mitta, Guillaume, Theron, Andre, and Magnaval, Jean-Francois

Subjects
Health
Abstract

To the Editor: In Europe, urinary schistosomiasis (1) has previously been detected only in Portugal, where this focus disappeared during the 1950s (2). However, freshwater snails of the species Bulinus [...]

Published
2014

27. No evidence of pathogenicity of Dientamoeba fragilisfollowing detection in stools: A case-control study

Author

Tchamwa Bamini, Germain, Charpentier, Eléna, Guemas, Emilie, Chauvin, Pamela, Fillaux, Judith, Valentin, Alexis, Cassaing, Sophie, Ménard, Sandie, Berry, Antoine, Iriart, Xavier, Tchamwa Bamini, Germain, Charpentier, Eléna, Guemas, Emilie, Chauvin, Pamela, Fillaux, Judith, Valentin, Alexis, Cassaing, Sophie, Ménard, Sandie, Berry, Antoine, and Iriart, Xavier

Abstract

Dientamoeba fragilisis a ubiquitous intestinal parasite with detection in the stools that has become increasingly frequent following the advent of PCR as a routine screening tool. However, the pathogenicity of this parasite is still much debated. In order to assess the potentially pathogenic nature of this protozoan, a retrospective case-control study was carried out between January and December 2020 on patients from Toulouse University Hospital, with the aim of evaluating the potential clinical effects and changes in laboratory parameters linked to the presence and load of D. fragilisin stools. After matching age, sex and mode of care (consultation or hospitalisation), no significant difference was observed in the frequency of clinical signs between the 36 patients who tested positive for Dientamoeba fragilisPCR in their stools and the 72 control patients who were PCR negative for this protozoan. The presence of D. fragilisin the faeces was not associated with changes in laboratory parameters. Furthermore, a high digestive load of D. fragilishad no identifiable impact on clinical and laboratory parameters. Only the concomitant presence of Blastocystissp. in stools was significantly more frequent in the D. fragilisgroup (uni- and multivariate analysis). Finally, this study showed no significant difference in clinical or laboratory signs between patients carrying Dientamoeba fragilisand the control group, regardless of the intestinal parasite load, suggesting that D. fragiliscould be considered a commensal of the digestive tract.

Published
2024
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30. Real-time PCR for diagnosis of imported schistosomiasis

Author

Guegan, Hélène, primary, Fillaux, Judith, additional, Charpentier, Eléna, additional, Robert-Gangneux, Florence, additional, Chauvin, Pamela, additional, Guemas, Emilie, additional, Boissier, Jérôme, additional, Valentin, Alexis, additional, Cassaing, Sophie, additional, Gangneux, Jean-Pierre, additional, Berry, Antoine, additional, and Iriart, Xavier, additional

Published
2019
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32. Prenatal therapy with pyrimethamine + sulfadiazine vs spiramycin to reduce placental transmission of toxoplasmosis: a multicenter, randomized trial

Author

Mandelbrot, Laurent, primary, Kieffer, François, additional, Sitta, Rémi, additional, Laurichesse-Delmas, Hélène, additional, Winer, Norbert, additional, Mesnard, Louis, additional, Berrebi, Alain, additional, Le Bouar, Gwenaëlle, additional, Bory, Jean-Paul, additional, Cordier, Anne-Gaëlle, additional, Ville, Yves, additional, Perrotin, Franck, additional, Jouannic, Jean-Marie, additional, Biquard, Florence, additional, d’Ercole, Claude, additional, Houfflin-Debarge, Véronique, additional, Villena, Isabelle, additional, Thiébaut, Rodolphe, additional, Pons, Denis, additional, Nourrisson, C., additional, Lavergne, Rose-Anne, additional, Fillaux, Judith, additional, Assouline, Corinne, additional, Robert-Gangneux, Florence, additional, L’Ollivier, Coralie, additional, Bretelle, Florence, additional, Guidicelli, Béatrice, additional, Garcia, Patricia, additional, Cordier, Anne-Gaelle, additional, Benachi, Alexandra, additional, Vauloup-Fellous, Christelle, additional, Letamendia, Emmanuelle, additional, Bougnoux, Marie-Elisabeth, additional, Van Langendonck, Nathalie, additional, Potin, Jérôme, additional, Marty, Pierre, additional, Pomarès, Christelle, additional, Trastour, Cynthia, additional, Deleplancque, Anne Sophie, additional, Costa, Jean-Marc, additional, Chève, Marie-Thérèse, additional, Col, Jean-Yves, additional, Cimon, Bernard, additional, Sterkers, Y., additional, Lachaud, Laurence, additional, Burlet, Gilles, additional, Maréchaud, Martine, additional, Perraud, Estelle, additional, Grébille, Anne-Gaelle, additional, Valentin, Morgane, additional, Houzé, Sandrine, additional, Omnès, Sophie, additional, Chitrit, Yvon, additional, Boissinot, Christine, additional, Yéra, Hélène, additional, Anselem, Olivia, additional, Tsatsaris, Vassilis, additional, Sénat, Marie-Victoire, additional, Fuchs, Florent, additional, Angoulvant, Adela, additional, Muszynski, Charles, additional, Totet, Anne, additional, Noël, Catherine, additional, Bidat, Laurent, additional, Barjat, Tiphaine, additional, Flori, Pierre, additional, Pelloux, Hervé, additional, Brenier-Pinchart, Marie-Pierre, additional, Thong-Vanh, Catherine, additional, Mandelbrot, Laurent, additional, Floch, Corinne, additional, Carbillon, Lionel, additional, Lachassine, Eric, additional, Ricbourg, Aude, additional, Paris, Luc, additional, Dommergues, Marc, additional, Rousseau, Thierry, additional, Dalle, Frederic, additional, Dardé, Marie Laure, additional, Aubard, Véronique, additional, Olivier, Camille, additional, Verspyk, Eric, additional, and Favennec, Loic, additional

Published
2018
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33. Persistence of schistosomal transmission linked to the Cavu river in southern Corsica since 2013

Author

Ramalli, Lauriane, primary, Mulero, Stephen, additional, Noël, Harold, additional, Chiappini, Jean-Dominique, additional, Vincent, Josselin, additional, Barré-Cardi, Hélène, additional, Malfait, Philippe, additional, Normand, Guillaume, additional, Busato, Florian, additional, Gendrin, Vincent, additional, Allienne, Jean-François, additional, Fillaux, Judith, additional, Boissier, Jérôme, additional, and Berry, Antoine, additional

Published
2018
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37. Metabiobiote

Author

Adele Dit De Renseville, Nathalie, Nguyen, Do Ngoc Linh, Vandenborght, Louise-Eva, Terrat, Sébastien, Gantois, Nausicaa, Ranjard, Lionel, Delhaes, Laurence, Ferreira, Stephanie, Thumerelle, C, Wizla, N, Tuck, D, Cassaing, Sophie, Fillaux, Judith, Brémont, F, Murris, M, Genoscreen [Lille], Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, GenoSol (plateforme de l'université de Bourgogne), Agroécologie [Dijon], Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Service de Parasitologie-Mycologie [CHRU LIlle], Institut de Microbiologie [CHRU Lille], Pôle de Biologie Pathologie Génétique [CHU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Pôle de Biologie Pathologie Génétique [CHU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Pharmacochimie et Biologie pour le Développement (PHARMA-DEV), Institut de Recherche pour le Développement (IRD)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

39. Re-emergence of urinary schistosomiasis in Europe ? Infections acquired in Southern Corsica – Investigation of a cluster of Schistosoma haematobium infections in 2014

Author

L. Ramalli, Noël, Harold, Ruello, Marc, Maccary, A., Boissier, Jerome, Barré-Cardi, Hélène, Fillaux, Judith, Termignon, J.L., Debruyne, Monique, Chyderiotis, G., Denoyel, G.A., T. Succo, A. Armengaud, M.-C. Paty, Heuzé, Guillaume, Mattei, J., Théron, André, and Berry, Antoine

Published
2015
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46. High negative predictive value diagnostic strategies for the reevaluation of early antifungal treatment: A multicenter prospective trial in patients at risk for invasive fungal infections

Author

Hasseine, Lilia, primary, Cassaing, Sophie, additional, Robert-Gangneux, Florence, additional, Fillaux, Judith, additional, Marty, Pierre, additional, Gangneux, Jean-Pierre, additional, Sirvent, Anne, additional, Mondain, Véronique, additional, Hyvernat, Hervé, additional, Rosenthal, Eric, additional, Cointault, Olivier, additional, Lavayssière, Laurence, additional, Georges, Bernard, additional, Berry, Antoine, additional, de Guibert, Sophie, additional, Nimubona, Stanislas, additional, Revest, Matthieu, additional, and Tattevin, Pierre, additional

Published
2015
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50. Mucormycose pulmonaire chez un enfant diabétique

Author

Fougère, Claire, Bremont, François, Serres, Isabelle, Iriart, Xavier, Fillaux, Judith, Gayda, Fabien, Martin-Blondel, Guillaume, Berry, Antoine, Berjaud, Jean, Da Costa, Maeva, Chauvin, Pamela, Martin-Blondel, Audrey, Blanchon, Sylvain, Lanternier, Fanny, Lortholary, Olivier, Dahan, Marcel, and Cassaing, Sophie

Published
2017
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