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1. Comparison of Incidence and Clinical Outcomes of COVID-19 among Healthcare Workers in the Prevaccination and Post-vaccination Periods: A Real-world Impact Study

Author: Serkan Surme, Betul Copur, Osman Faruk Bayramlar, Gulsah Tuncer, Yusuf Emre Ozdemir, Filiz Pehlivanoglu, and Gonul Sengoz
Subjects: covid-19, vaccination, incidence, healthcare workers, Medicine, Medicine (General), R5-920
Abstract: Aim:Real-life data on the effect of coronavirus disease-2019 (COVID-19) vaccination is limited. We aimed to compare the incidence of COVID-19 among healthcare workers (HCWs) in the pre-vaccination and post-vaccination periods during the COVID-19 pandemic and identify associated factors for COVID-19 development.Methods:In this single-center and cross-sectional study, HCWs employed in a tertiary care hospital were included. Pre-vaccination (14 October, 2020 and 14 January, 2021) and post-vaccination periods (1 March, 2021 and 1 June, 2021) were compared. A subgroup analysis was performed on HCWs without a previous history of COVID-19. Additionally, univariate regression analysis of COVID-19 development in the post-vaccination period was performed.Results:Of 2,922 HCWs, 2,096 (71.7%) were vaccinated. The incidence of COVID-19 was higher in the pre-vaccination period (16.3%) than in the post-vaccination (6.6%) (p
Published: 2022
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2. The diagnostic utility of the 'Thwaites’ system' and 'lancet consensus scoring system' in tuberculous vs. non-tuberculous subacute and chronic meningitis: multicenter analysis of 395 adult patients

Author: Tarek Sulaiman, Sai Medi, Hakan Erdem, Seniha Senbayrak, Derya Ozturk-Engin, Asuman Inan, Rok Civljak, Mihai Nechifor, Ayhan Akbulut, Alexandru Crisan, Muge Ozguler, Mustafa Namiduru, Branislava Savic, Olga Dulovic, Filiz Pehlivanoglu, Gonul Sengoz, Kadriye Yasar, Ayse Seza Inal, Emine Parlak, Isik Somuncu Johansen, Ebru Kursun, Mehmet Parlak, Emel Yilmaz, Gulden Yilmaz, Hanefi Cem Gul, Oral Oncul, Soline Siméon, Pierre Tattevin, Aysegul Ulu-Kilic, Selma Alabay, Bojana Beovic, Melanie Catroux, Yves Hansmann, Arjan Harxhi, Alper Sener, Hacer Deniz Ozkaya, Yasemin Cağ, Canan Agalar, Haluk Vahaboglu, Berna Kaya Ugur, and Rodrigo Hasbun
Subjects: Tuberculous, Subacute, Meningitis, Thwaites, Lancet, Criteria, Infectious and parasitic diseases, RC109-216
Abstract: Abstract Background Tuberculous meningitis (TBM) represents a diagnostic and management challenge to clinicians. The “Thwaites’ system” and “Lancet consensus scoring system” are utilized to differentiate TBM from bacterial meningitis but their utility in subacute and chronic meningitis where TBM is an important consideration is unknown. Methods A multicenter retrospective study of adults with subacute and chronic meningitis, defined by symptoms greater than 5 days and less than 30 days for subacute meningitis (SAM) and greater than 30 days for chronic meningitis (CM). The “Thwaites’ system” and “Lancet consensus scoring system” scores and the diagnostic accuracy by sensitivity, specificity, and area under the curve of receiver operating curve (AUC-ROC) were calculated. The “Thwaites’ system” and “Lancet consensus scoring system” suggest a high probability of TBM with scores ≤4, and with scores of ≥12, respectively. Results A total of 395 patients were identified; 313 (79.2%) had subacute and 82 (20.8%) with chronic meningitis. Patients with chronic meningitis were more likely caused by tuberculosis and had higher rates of HIV infection (P
Published: 2020
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3. Influence of multidrug resistant organisms on the outcome of diabetic foot infection

Author: Nese Saltoglu, Onder Ergonul, Necla Tulek, Mucahit Yemisen, Ayten Kadanali, Gul Karagoz, Ayse Batirel, Oznur Ak, Cagla Sonmezer, Haluk Eraksoy, Atahan Cagatay, Serkan Surme, Salih A. Nemli, Tuna Demirdal, Omer Coskun, Derya Ozturk, Nurgul Ceran, Filiz Pehlivanoglu, Gonul Sengoz, Turan Aslan, Yasemin Akkoyunlu, Oral Oncul, Hakan Ay, Lutfiye Mulazımoglu, Buket Erturk, Fatma Yilmaz, Gulsen Yoruk, Nuray Uzun, Funda Simsek, Taner Yildirmak, Kadriye Kart Yaşar, Meral Sonmezoglu, Yasar Küçükardali, Nazan Tuna, Oguz Karabay, Nail Ozgunes, and Fatma Sargın
Subjects: Infectious and parasitic diseases, RC109-216
Abstract: Objectives: We described the clinical outcomes of the diabetic patients who had foot infections with multidrug resistant organisms. Methods: We included the patients with diabetic foot infections (DFI) from 19 centers, between May 2011 and December 2015. Infection was defined according to IDSA DFI guidelines. Patients with severe infection, complicated moderate infection were hospitalized. The patients were followed-up for 6 months after discharge. Results: In total, 791 patients with DFI were included, 531(67%) were male, median age was 62 (19–90). Severe infection was diagnosed in 85 (11%) patients. Osteomyelitis was diagnosed in 291(36.8%) patients. 536 microorganisms were isolated, the most common microorganisms were S. aureus (20%), P. aeruginosa (19%) and E. coli (12%). Methicillin resistance (MR) rate among Staphylococcus aureus isolates was 31%. Multidrug resistant bacteria were detected in 21% of P. aeruginosa isolates. ESBL (+) Gram negative bacteria (GNB) was detected in 38% of E. coli and Klebsiella isolates. Sixty three patients (8%) were re-hospitalized. Of the 791 patiens, 127 (16%) had major amputation, and 24 (3%) patients died. In multivariate analysis, significant predictors for fatality were; dialysis (OR: 8.3, CI: 1.82–38.15, p = 0.006), isolation of Klebsiella spp. (OR:7.7, CI: 1.24–47.96, p = 0.028), and chronic heart failure (OR: 3, CI: 1.01–9.04, p = 0.05). MR Staphylococcus was detected in 21% of the rehospitalized patients, as the most common microorganism (p
Published: 2018
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4. Tricuspid Endocarditis and Septic Pulmonary Embolism in an Intravenous Drug User with advanced HIV Infection

Author: Gonul Sengoz, Sevtap Gursoy, Filiz Pehlivanoglu, and Kadriye Kart Yasar
Subjects: daptomycin, HIV infection, infective endocarditis, Intravenous drug user, Right-sided endocarditis, Tricuspid Valve, Medicine
Abstract: Cardiac complications are becoming increasingly important in patients with HIV infection. Right-sided endocarditis are more common in intravenous drug users (IVDU) with HIV infection. Some studies have pointed out that the clinical outcome of such patients depends on the affected valve referred to the responsible agent rather than the HIV serostatus. However, severe immunosupression and low CD4 count are associated with increased risk of death. This report presents a case of isolated tricuspid valve endocarditis with advanced HIV infection who was also an IVDU.
Published: 2011

5. Tuberculous Meningitis in Adults: A Review of 160 Cases

Author: Filiz Pehlivanoglu, Kadriye Kart Yasar, and Gonul Sengoz
Subjects: Technology, Medicine, Science
Abstract: Objective. This study aimed to evaluate epidemiological, clinical, laboratory, and neuroimaging features of 160 adult patients with tuberculous meningitis (TBM) according to “Thwaites’ diagnostic index.” Methods. The subjects of this retrospective study are the patients with TBM who were followed up between years 1998 and 2009 in a tertiary referral hospital. Diagnosis of TBM was based on clinical, laboratory, and neuroimaging signs and Thwaites’ diagnostic index. Results. Mycobacterium tuberculosis was isolated from CSF in 59 of 148 patients. Seventeen percent of the patients died, 71% recovered completely, and 13% recovered with neurological sequel at the end of the sixth month. Conclusions. Despite new developments in laboratory or neuroimaging techniques, the diagnosis of TBM is still based on clinical features with the help of laboratory. Early diagnosis by suspecting TBM may prevent therapy delay and may result in decrease in the mortality and morbidity.
Published: 2012
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6. AIDS and disseminated tuberculosis after Immune Reconstitution Inflammatory Syndrome

Author: Gonul Sengoz, Ahmet Sengoz, and Filiz Pehlivanoglu
Subjects: Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
Published: 2014
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7. The effects of the time of intranasal splinting on bacterial colonization, postoperative complications, and patient discomfort after septoplasty operations

Author: Abdullah Karatas, Filiz Pehlivanoglu, Mehti Salviz, Nuray Kuvat, Isil Taylan Cebi, Burak Dikmen, and Gonul Sengoz
Subjects: Splint nasal, Conforto do paciente, Septoplastia, Otorhinolaryngology, RF1-547
Abstract: Abstract Introduction: The main reason for nasal tampon placement after septoplasty is to prevent postoperative hemorrhage, while the secondary purpose is internal stabilization after operations involving the cartilaginous-bony skeleton of the nose. Silicone intranasal splints are as successful as other materials in controlling postoperative hemorrhages of septal origin. The possibility of leaving the splints intranasally for extended periods helps stabilize the septum in the midline. However, there is nothing in the literature about how long these splints can be retained inside the nasal cavity without increasing the risk of infection, postoperative complications, and patient discomfort. Objective: The current study aimed to evaluate the association between the duration of intranasal splinting and bacterial colonization, postoperative complications, and patient discomfort. Methods: Patients who had undergone septoplasty were divided into three groups according to the day of removal of the silicone splints. The splints were removed on the fifth, seventh, and tenth postoperative days. The removed splints were microbiologically cultured. Early and late complications were assessed, including local and systemic infections, tissue necrosis, granuloma formation, mucosal crusting, synechia, and septal perforation. Postoperative patient discomfort was evaluated by scoring the levels of pain and nasal obstruction. Results: No significant difference was found in the rate of bacterial colonization among the different groups. Decreased mucosal crusting and synechia were detected with longer usage intervals of intranasal silicone splints. Postoperative pain and nasal obstruction were also diminished by the third postoperative day. Conclusions: Silicone splints were well tolerated by the patients and any negative effects on postoperative patient comfort were limited. In fact, prolonged splint usage intervals reduced late complications. Long-term silicone nasal splint usage is a reliable, effective, and comfortable method in patients with excessive mucosal damage and in whom long-term stabilization of the bony and cartilaginous septum is essential.
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8. Long-term effects of COVID-19 on lungs and the clinical relevance: a 6-month prospective cohort study

Author: Gulsah Tuncer, Ceyda Geyiktepe-Guclu, Serkan Surme, Evren Canel-Karakus, Hatice Erdogan, Osman F Bayramlar, Cansu Belge, Ridvan Karahasanoglu, Betul Copur, Meltem Yazla, Esra Zerdali, Inci Y Nakir, Nihal Yildirim, Bedriye Kar, Mediha Bozkurt, Kubra Karanalbant, Burcu Atasoy, Hindirin Takak, Serap Simsek-Yavuz, Rustu Turkay, Mehmet M Sonmez, Gonul Sengoz, and Filiz Pehlivanoglu
Subjects: Microbiology (medical), Microbiology
Abstract: Background: We aimed to explore the prevalence of prolonged symptoms, pulmonary impairments and residual disease on chest tomography (CT) in COVID-19 patients at 6 months after acute illness. Methods: In this prospective, single-center study, hospitalized patients with radiologically and laboratory-confirmed COVID-19 were included. Results: A high proportion of the 116 patients reported persistent symptoms (n = 54; 46.6%). On follow-up CT, 33 patients (28.4%) demonstrated residual disease. Multivariate analyses revealed that only neutrophil-to-lymphocyte ratio was an independent predictor for residual disease. Conclusion: Hospitalized patients with mild/moderate COVID-19 still had persistent symptoms and were prone to develop long-term pulmonary sequelae on chest CT. However, it did not have a significant effect on long-term pulmonary functions.
Published: 2023

9. Risk Factors and Predictors of 1-year Overall Mortality in Patients with COVID-19

Author: Serkan Surme, Gulsah Tuncer, Osman Faruk Bayramlar, Hindirin Takak, Betul Copur, Meltem Yazla, Esra Zerdali, Inci Yilmaz Nakir, Gonul Sengoz, and Filiz Pehlivanoglu
Subjects: General Medicine
Published: 2022

10. Comparison of clinical, laboratory and radiological features in confirmed and unconfirmed COVID-19 patients

Author: Meltem Yazla, Esra Zerdali, Inci Yilmaz Nakir, Gonul Sengoz, Gulsah Tuncer, Betul Copur, Hatice Balli, Serkan Surme, Ayse Ruhkar Kurt Cinar, Yesim Kurekci, Filiz Pehlivanoglu, Ahmet Buyukyazgan, and Osman Faruk Bayramlar
Subjects: Adult, Male, Microbiology (medical), myalgia, medicine.medical_specialty, complete blood count, Multivariate analysis, Adolescent, diagnosis, Microbiology, close contact, Young Adult, Internal medicine, medicine, book.illustrator, Humans, Stage (cooking), book, Aged, Retrospective Studies, platelet, Aged, 80 and over, Univariate analysis, medicine.diagnostic_test, SARS-CoV-2, business.industry, COVID-19, Complete blood count, Retrospective cohort study, SARS-CoV-2 PCR, Middle Aged, Thorax, Blood Cell Count, Radiography, Radiological weapon, Female, medicine.symptom, Tomography, X-Ray Computed, Unconfirmed, business, Research Article
Abstract: Background: We aimed to compare the clinical, laboratory and radiological findings of confirmed COVID-19 and unconfirmed patients. Methods: This was a single-center, retrospective study. Results: Overall, 620 patients (338 confirmed COVID-19 and 282 unconfirmed) were included. Confirmed COVID‐19 patients had higher percentages of close contact with a confirmed or probable case. In univariate analysis, the presence of myalgia and dyspnea, decreased leukocyte, neutrophil and platelet counts were best predictors for SARS-CoV-2 RT-PCR positivity. Multivariate analyses revealed that only platelet count was an independent predictor for SARS-CoV-2 RT-PCR positivity. Conclusion: Routine complete blood count may be helpful for distinguishing COVID-19 from other respiratory illnesses at an early stage, while PCR testing is unique for the diagnosis of COVID-19.
Published: 2021

11. Effectiveness of CoronaVac vaccination against COVID-19 development in healthcare workers: real-life data

Author: Betul Copur, Serkan Surme, Ugurcan Sayili, Gulsah Tuncer, Filiz Pehlivanoglu, and Gonul Sengoz
Subjects: Microbiology (medical), COVID-19 Vaccines, SARS-CoV-2, Health Personnel, Vaccination, Humans, COVID-19, Microbiology
Abstract: Background: This study was designed to investigate the effectiveness of CoronaVac in preventing COVID-19 in healthcare workers (HCWs) during the Alpha variant-dominant period. Materials & methods: Follow-up was initiated 14 days after the second dose for double-dose vaccinated HCWs and on 25 February 2021, for the unvaccinated group. The incidence rate ratio was calculated to estimate the unadjusted effectiveness. Cox regression was used to adjust the effectiveness of CoronaVac. Results & Conclusion: The adjusted effectiveness of CoronaVac against COVID-19 was 65% (95% CI: 50–75%). Compared with the results of the phase III trial conducted in Turkey, a lower effectiveness of CoronaVac against COVID-19 was detected in this real-life study. This finding suggests that mass vaccination and booster doses are needed.
Published: 2022

12. Blood types (ABO/Rhesus) and SARS-CoV-2 infection: a retrospective, cross-sectional study in 2828 healthcare workers

Author: Betul Copur, Serkan Surme, Ugurcan Sayili, Gulsah Tuncer, Melike Nur Ozcelik, Hulya Yilmaz-Ak, Muge Topal, Sumeyye Ustun-Al, Filiz Pehlivanoglu, and Gonul Sengoz
Subjects: Virology
Abstract: Background: The authors aimed to investigate the relationship between ABO/Rhesus blood types and the risk of SARS-CoV-2 infection and hospitalization in healthcare workers (HCWs). Materials & methods: This study compared HCWs with (n = 510) and without (n = 2318) SARS-CoV-2 infection. Risk factors for SARS-CoV-2 infection and hospitalization in HCWs were shown as odds ratios with 95% CI. Results: Blood group O was found to be protective by 20% from the risk of developing SARS-CoV-2 infection in HCWs (29.2 vs 33.8%; odds ratio: 0.808; 95% CI: 0.655–0.996; p = 0.045). The prevalence of group O was lower in hospitalized patients than in outpatients (25 vs 29.5%; p = 0.614). Conclusion: These findings suggest that blood groups are associated with the development of SARS-CoV-2 infection.
Published: 2022

13. Novel biomarker-based score (SAD-60) for predicting mortality in patients with COVID-19 pneumonia: a multicenter retrospective cohort of 1013 patients

Author: Serkan Surme, Gulsah Tuncer, Osman F Bayramlar, Betul Copur, Esra Zerdali, Inci Y Nakir, Meltem Yazla, Ahmet Buyukyazgan, Ayse RK Cinar, Yesim Kurekci, Mustafa Alkan, Yusuf E Ozdemir, Gonul Sengoz, and Filiz Pehlivanoglu
Subjects: Male, SARS-CoV-2, Biochemistry (medical), Clinical Biochemistry, COVID-19, Middle Aged, Prognosis, Severity of Illness Index, Albumins, Drug Discovery, Humans, Female, Hospital Mortality, Biomarkers, Aged, Retrospective Studies
Abstract: Background: The aim was to explore a novel risk score to predict mortality in hospitalized patients with COVID-19 pneumonia. Methods: This was a retrospective, multicenter study. Results: A total of 1013 patients with COVID-19 were included. The mean age was 60.5 ± 14.4 years, and 581 (57.4%) patients were male. In-hospital death occurred in 124 (12.2%) patients. Multivariate analysis revealed peripheral capillary oxygen saturation (SpO2), albumin, D-dimer and age as independent predictors. The mortality score model was given the acronym SAD-60, representing SpO2, Albumin, D-dimer, age ≥60 years. The SAD-60 score (0.776) had the highest area under the curve compared with CURB-65 (0.753), NEWS2 (0.686) and qSOFA (0.628) scores. Conclusion: The SAD-60 score has a promising predictive capacity for mortality in hospitalized patients with COVID-19.
Published: 2022

14. Predictors of Intensive Care Unit Admission or Mortality in Patients with Coronavirus Disease 2019 Pneumonia in Istanbul, Turkey

Author: Yesim Kurekci, Ahmet Buyukyazgan, Gulsah Tuncer, Filiz Pehlivanoglu, Ayse Ruhkar Kurt Cinar, Meltem Yazla, Gonul Sengoz, Serkan Surme, Betul Copur, Inci Yilmaz Nakir, Osman Faruk Bayramlar, Hatice Balli, and Esra Zerdali
Subjects: Microbiology (medical), Adult, Male, medicine.medical_specialty, Turkey, Procalcitonin, law.invention, Interquartile range, law, Risk Factors, Internal medicine, medicine, Humans, Hospital Mortality, Aged, Retrospective Studies, Univariate analysis, business.industry, SARS-CoV-2, COVID-19, Retrospective cohort study, General Medicine, Odds ratio, Middle Aged, medicine.disease, Prognosis, Intensive care unit, Confidence interval, Hospitalization, Pneumonia, Intensive Care Units, Infectious Diseases, Female, business
Abstract: We aimed to determine the predictors of intensive care unit (ICU) admission or death in patients with coronavirus disease 2019 (COVID-19) pneumonia. This retrospective, single-center study included patients aged ≥18 years who were diagnosed with COVID-19 pneumonia (laboratory and radiologically confirmed) between March 9 and April 8, 2020. The composite endpoint was ICU admission or in-hospital mortality. Univariate and multivariate logistic regression analyses were performed to evaluate the factors associated with the composite endpoint. A total of 336 patients with COVID-19 pneumonia were evaluated. The median age was 54 years (interquartile range: 21), and 187 (55.7%) were men. Fifty-one (15.2%) patients were admitted to the ICU. In-hospital mortality occurred in 33 patients (9.8%). In the univariate analysis, 17 parameters were associated with the composite endpoint, and procalcitonin had the highest odds ratio (odds ratio [OR] = 36.568, confidence interval [CI] = 5.145-259.915). Our results revealed that body temperature (OR = 1.489, CI = 1.023-2.167, P = 0.037), peripheral capillary oxygen saturation (SpO2) (OR = 0.835, CI = 0.773-0.901, P0.001), and consolidation (25%) on chest computed tomography (OR = 3.170, CI = 1.218-8.252, P = 0.018) at admission were independent predictors. As a result, increased body temperature, decreased SpO2, a high level of procalcitonin, and degree of consolidation on chest computed tomography may predict a poor prognosis and have utility in the management of patients.
Published: 2021

15. NEWS2 and laboratory predictors correlated with clinical deterioration in hospitalised patients with COVID-19

Author: Meltem Yazla, Ahmet Buyukyazgan, Esra Zerdali, Mehmet Mesut Sonmez, Ayse Ruhkar Kurt-Cinar, Hatice Kubra Karanalbant, Serap Simsek-Yavuz, Hatice Balli, Filiz Pehlivanoglu, Inci Yilmaz-Nakir, Yesim Kurekci, Betul Copur, Gulsah Tuncer, Gonul Sengoz, Serkan Surme, and Osman Faruk Bayramlar
Subjects: medicine.medical_specialty, Univariate analysis, Coronavirus disease 2019 (COVID-19), Receiver operating characteristic, business.industry, Clinical course, Odds ratio, Logistic regression, Intensive care unit, Procalcitonin, law.invention, law, Internal medicine, medicine, business
Abstract: BackgroundWe aimed to determine prognostic values of NEWS2 and laboratory parameters during the first week of COVID-19.MethodsAll adult patients who were hospitalized for a confirmed COVID-19 between the 11th of March and the 11th of May 2020 were retrospectively included. To evaluate the factors in prognosis which are admission to intensive care unit (ICU) and in-hospital death, univariate logistic regression analysis was performed at admission (D0), at day-3 (D3), day-5 (D5), and day-7 (D7). Additionally, receiver operating characteristic (ROC) analyses were performed.ResultsOverall, 611 patients were included. Clinical deterioration was observed in 79 (12.9%) patients during hospitalisation, 36 (5.9%) during the first three days, 54 (8.8%) during the first five days, and 62 (10.1%) during the first week of hospitalisation. Our results showed that NEWS2, procalcitonin, neutrophil/lymphocyte ratio (NLR), and albumin were the best predictors for clinical deterioration at D0, D3, D5, and D7. Procalcitonin had the highest odds ratio for clinical deterioration on all days in univariate analysis. ROC analyses showed that NEWS2 at D7, procalcitonin at D5, albumin at D7, and NLR at D5 had highest AUC values. Additionally, we detected a strong correlation between NEWS2 and laboratory parameters including neutrophil, lymphocyte, NLR, platelet/lymphocyte ratio, CRP, procalcitonin, ferritin, and urea on all days.ConclusionThis study provides a list of several laboratory parameters correlated with NEWS2 and potential predictors for ICU admission or in-hospital death during the clinical course of COVID-19. Dynamic monitoring of NEWS2 and laboratory parameters is vital for improving clinical outcomes.
Published: 2021

16. The diagnostic utility of the 'Thwaites' system' and 'lancet consensus scoring system' in tuberculous vs. non-tuberculous subacute and chronic meningitis: multicenter analysis of 395 adult patients

Author: Berna Kaya Ugur, Arjan Harxhi, Yves Hansmann, Alper Şener, Melanie Catroux, Mihai Nechifor, Hanefi Cem Gül, Haluk Vahaboglu, Selma Alabay, Emel Yilmaz, Emine Parlak, Hacer Deniz Ozkaya, Kadriye Kart Yaşar, Isik Somuncu Johansen, Soline Simeon, Seniha Senbayrak, Canan Agalar, Pierre Tattevin, Ayhan Akbulut, Gulden Yilmaz, Ayşe Seza Inal, Filiz Pehlivanoglu, Olga Dulovic, Asuman Inan, Oral Oncul, Yasemin Cag, Alexandru Crişan, Derya Ozturk-Engin, Mehmet Parlak, Rodrigo Hasbun, Ebru Kurşun, Rok Čivljak, Bojana Beović, Mustafa Namiduru, Hakan Erdem, Aysegul Ulu-Kilic, Branislava Savic, Gonul Sengoz, Tarek Sulaiman, Muge Ozguler, Sai Medi, The University of Texas Health Science Center at Houston (UTHealth), Zagreb School of Medicine [Zagreb, Croatia] (Dubrava University Hospital), University of Zagreb, University of Medicine and Pharmacy 'Grigore T.Popa' Iasi (UMF lasi), Firat University, Victor Babeş University of Medicine and Pharmacy (UMFT), Gaziantep University, University of Belgrade [Belgrade], Cukurova University, Atatürk Üniversitesi, Odense University Hospital [Odense, Denmark], Başkent University Hospital [Adana, Turkey], Uludağ Üniversitesi = Uludag University, Gulhane Training and Research Hospital, Istanbul University, CHU Pontchaillou [Rennes], ARN régulateurs bactériens et médecine (BRM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Erciyes University, University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Centre hospitalier universitaire de Poitiers (CHU Poitiers), CHU Strasbourg, University of Tirana, Çanakkale Onsekiz Mart University (COMU), Istanbul Medeniyet University [Istanbul, Turquie] (IMU), National Center for Research Resources United States Department of Health and Human ServicesNational Institutes of Health (NIH) - USA NIH National Center for Research Resources (NCRR) [NIH-1 K23 RR018929-01A2], Grant A Starr Foundation, and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Male, AIDS-Related Opportunistic Infections/diagnosis, [SDV]Life Sciences [q-bio], Tuberculous, urologic and male genital diseases, 0302 clinical medicine, Medicine, 030212 general & internal medicine, CSF albumin, Cryptococcus neoformans/immunology, Aged, 80 and over, Meningitis, Viral/cerebrospinal fluid, Cryptococcosis, Middle Aged, Meningitis, Viral, 3. Good health, Infectious Diseases, Mycobacterium tuberculosis/genetics, Research Design, Tuberculosis, Meningeal, Area Under Curve, Thwaites, HIV/genetics, Female, Meningitis, Research Article, Adult, medicine.medical_specialty, Subacute, Adolescent, CSF glucose, 030231 tropical medicine, Cryptococcosis/diagnosis, Sensitivity and Specificity, Tuberculous meningitis, lcsh:Infectious and parasitic diseases, Diagnosis, Differential, Lancet, Young Adult, 03 medical and health sciences, Meningitis, Fungal/cerebrospinal fluid, Internal medicine, Humans, lcsh:RC109-216, Retrospective Studies, Aged, AIDS-Related Opportunistic Infections, Receiver operating characteristic, business.industry, Glasgow Coma Scale, HIV, Retrospective cohort study, Mycobacterium tuberculosis, medicine.disease, Criteria, Meningitis, Fungal, Tuberculosis, Meningeal/cerebrospinal fluid, Chronic Disease, Cryptococcus neoformans, Etiology, business
Abstract: BackgroundTuberculous meningitis (TBM) represents a diagnostic and management challenge to clinicians. The“Thwaites’ system” and “Lancet consensus scoring system” are utilized to differentiate TBM from bacterial meningitis but their utility in subacute and chronic meningitis where TBM is an important consideration is unknown.MethodsA multicenter retrospective study of adults with subacute and chronic meningitis, defined by symptoms greater than 5 days and less than 30 days for subacute meningitis (SAM) and greater than 30 days for chronic meningitis (CM). The “Thwaites’ system” and “Lancet consensus scoring system” scores and the diagnostic accuracy by sensitivity, specificity, and area under the curve of receiver operating curve (AUC-ROC) were calculated. The “Thwaites’ system” and “Lancet consensus scoring system” suggest a high probability of TBM with scores ≤4, and with scores of ≥12, respectively.ResultsA total of 395 patients were identified; 313 (79.2%) had subacute and 82 (20.8%) with chronic meningitis. Patients with chronic meningitis were more likely caused by tuberculosis and had higher rates of HIV infection (P P P ConclusionBoth criteria can be helpful in distinguishing TBM from bacterial meningitis, but only the Lancet consensus scoring system can help differentiate TBM from meningitis caused by fungal, viral and unknown etiologies even though significant overlap occurs and the overall diagnostic accuracy of both criteria were either poor or fair.
Published: 2020

17. Clinicopathological profile of gastrointestinal tuberculosis: a multinational ID-IRI study

Author: Tolga Yakar, Zauresh Smagulova, Antonio Cascio, Ilker Inanc Balkan, Fatma Sirmatel, Tolga Duzenli, Sophia de Saram, Alpaslan Tanoglu, Serda Gulsun, Necati Örmeci, Hakan Erdem, Secil Deniz, Recep Tekin, Salih Cesur, Özlem Aydin, Nicolas Dauby, Affan Denk, Burak Ozseker, Aysegul Erdem, Ahsen Oncul, Fahad Almajid, Soline Simeon, Seniha Senbayrak, Ayse Batirel, Jon S. Friedland, Filiz Pehlivanoglu, Maiya Konkayeva, Sholpan Kulzhanova, Fatma A. Amer, Meltem Taşbakan, Ahmed Ashraf Wegdan, Tanoglu A., Erdem H., Friedland J.S., Almajid F.M., Batirel A., Kulzhanova S., Konkayeva M., Smagulova Z., Pehlivanoglu F., de Saram S., Gulsun S., Amer F., Balkan I.I., Tekin R., Cascio A., Dauby N., Sirmatel F., Tasbakan M., Erdem A., Wegdan A.A., Aydin O., Cesur S., Deniz S., Senbayrak S., Denk A., Duzenli T., Simeon S., Oncul A., Ozseker B., Yakar T., Ormeci N., Ege Üniversitesi, MÜ, İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, and Sırmatel, Fatma
Subjects: Male, Cirrhosis, medicine.medical_treatment, retrospective study, laparoscopy, Colonoscopy, multimodal imaging, Comorbidity, Gastroenterology, protionamide, 0302 clinical medicine, Laparotomy, Ascites, amikacin, Medicine, bedaquiline, Pathologie maladies infectieuses, intestine biopsy, adult, steroid, clinical trial, General Medicine, rifabutin, Microbiologie et protistologie [entomologie,phytoparasitolog.], priority journal, diabetes mellitus, histopathology, biological product, Microbiology (medical), Microbiologie et protistologie [parasitologie hum. et anim.], medicine.medical_specialty, Tuberculosis, 030106 microbiology, malignant neoplasm, Article, 03 medical and health sciences, laparotomy, Human immunodeficiency virus infection, molecular diagnosis, Humans, Gastro-intestinal, human, Retrospective Studies, colon, disease predisposition, microbiology, Immune-suppression, Endoscopy, anus, medicine.disease, major clinical study, multicenter study, aminosalicylic acid, cyclophosphamide, 0301 basic medicine, Biopsy, Antitubercular Agents, ethambutol, rifampicin, terminal ileum, colonoscopy, ofloxacin, 030212 general & internal medicine, Laparoscopy, azathioprine, medicine.diagnostic_test, Incidence (epidemiology), gastrointestinal tuberculosis, Disease Management, chronic kidney failure, cycloserine, Infectious Diseases, female, Treatment Outcome, Molecular Diagnostic Techniques, diagnostic test, Disease Susceptibility, medicine.symptom, moxifloxacin, Symptom Assessment, stomach, isoniazid, pyrazinamide, streptomycin, liver cirrhosis, patient referral, linezolid, Internal medicine, business.industry, Mycobacterium tuberculosis, human tissue, clinical feature, Treatment, Tuberculosis, Gastrointestinal, tuberculostatic agent, business, Microbiologie et protistologie [bacteriol.virolog.mycolog.]
Abstract: Data are relatively scarce on gastro-intestinal tuberculosis (GITB). Most studies are old and from single centers, or did not include immunosuppressed patients. Thus, we aimed to determine the clinical, radiological, and laboratory profiles of GITB. We included adults with proven GITB treated between 2000 and 2018. Patients were enrolled from 21 referral centers in 8 countries (Belgium, Egypt, France, Italy, Kazakhstan, Saudi Arabia, UK, and Turkey). One hundred four patients were included. Terminal ileum (n = 46, 44.2%), small intestines except terminal ileum (n = 36, 34.6%), colon (n = 29, 27.8%), stomach (n = 6, 5.7%), and perianal (one patient) were the sites of GITB. One-third of all patients were immunosuppressed. Sixteen patients had diabetes, 8 had chronic renal failure, 5 were HIV positive, 4 had liver cirrhosis, and 3 had malignancies. Intestinal biopsy samples were cultured in 75 cases (78.1%) and TB was isolated in 65 patients (86.6%). PCR were performed to 37 (35.6%) biopsy samples and of these, 35 (94.6%) were positive. Ascites samples were cultured in 19 patients and M. tuberculosis was isolated in 11 (57.9%). Upper gastrointestinal endoscopy was performed to 40 patients (38.5%) and colonoscopy in 74 (71.1%). Surgical interventions were frequently the source of diagnostic samples (25 laparoscopy/20 laparotomy, n = 45, 43.3%). Patients were treated with standard and second-line anti-TB medications. Ultimately, 4 (3.8%) patients died and 2 (1.9%) cases relapsed. There was a high incidence of underlying immunosuppression in GITB patients. A high degree of clinical suspicion is necessary to initiate appropriate and timely diagnostic procedures; many patients are first diagnosed at surgery., SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2019

18. Türkiye’de Görülen Zika Virüsü Olguları: Küba’dan Dönen Yeni Evli Çift

Author: Mustafa Yıldırım, Dilek Menemenlioğlu, Filiz Pehlivanoglu, Melike Nur Kültür, and Ayşegül İnci Sezen
Subjects: 0301 basic medicine, Microbiology (medical), Pediatrics, medicine.medical_specialty, viruses, 030231 tropical medicine, Dengue virus, medicine.disease_cause, Zika virus, Dengue fever, 03 medical and health sciences, 0302 clinical medicine, Maculopapular rash, medicine, Chikungunya, Aedes, General Immunology and Microbiology, biology, business.industry, 030108 mycology & parasitology, biology.organism_classification, medicine.disease, Flavivirus, Infectious Diseases, medicine.symptom, Headaches, business
Abstract: Zika virus is a Flavivirus in the family Flaviviridae, and transmitted to humans by Aedes species mosquitoes. Zika virus infection is asymptomatic in 80% of cases and has a mild course when symptoms occur. These symptoms include headache, myalgia, mild fever, maculopapular rash and conjunctivitis. Zika virus has been associated with serious neurological complications such as Guillain-Barre syndrome in adults and microcephaly development in neonates. It has recently become a global public health problem as a result of increasing cases. As it is known that the vector of this disease is present in our country; entry of Zika virus infection in our country has a great importance. In this report the clinical and laboratory findings of two cases of Zika virus infection imported to Turkey by a couple returning from Cuba in October 2017 were presented. Newly married couple, both 29 years old, without a known chronic disease history, went on honeymoon to Cuba between 17-29 September and they visited Havana and Varadero. They reported that they were bitten repeatedly by the mosquitoes and did not use insect repellents during this time. Four days after returning to Turkey, they had headaches, back pain and myalgia followed by rash and joint pain. They reported having their symptoms started in the same day in a few hours difference. The symptoms for both patients disappeared in 10 days. Serum samples from the patients were sent to the Public Health General Directorate National Arboviruses and Viral Zoonoses Laboratory to be tested for Dengue, Chikungunya and Zika viruses. Nucleic acid testing yielded negative results. The Arbovirus Indirect Immunofluorescence test were positive both for IgM and IgG for Zika virus. No cross reactivity with Dengue virus was detected. Chikungunya antibodies were found as negative. At two months of the diagnosis, urine and semen samples of the male patient were tested by real-time reverse transcriptase polymerase chain reaction (rRT-PCR). The result was negative for urine but positive for semen sample. This report is important to present the first cases of Zika virus infection published in Turkey. Zika virus infection should be suspected in patients with fever, headache, rash, myalgia and joint pain returning from an endemic areas. All travelers, especially pregnant women, have to take precautions for mosquitos during the trip.
Published: 2018

19. Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome: Epidemiological Changes in the World and Turkey

Author: Filiz Pehlivanoglu and Gonul Sengoz
Subjects: lcsh:R5-920, medicine.medical_specialty, business.industry, lcsh:R, Human immunodeficiency virus (HIV), lcsh:Medicine, General Medicine, medicine.disease, medicine.disease_cause, Virology, Acquired immunodeficiency syndrome (AIDS), stigma, Epidemiology, medicine, epidemiology, lcsh:Medicine (General), business, Human Immunodeficiency Virus/Acquired Immunodeficiency syndrome
Abstract: Human Immunodeficiency Virus/Acquired Immunodeficiency syndrome pandemic has spread and affected the whole world. The features of the disease and the structure of the virus make it difficult to control the disease and epidemic. This disease, classified as a chronic disease, can be treated with antiretroviral drugs developed in recent years. It is important that countries follow population characteristics for disease epidemiology in terms of disease transmission. The fact that patients cannot reach treatment due to discrimination is one of the most important factors in the spread of the disease. Means of protection should be managed separately for each group, and education and screening programs should be implemented for vulnerable groups. The target is that 90% of patients are diagnosed, 90% are treated and viral suppression is maintained in 90% of patients.
Published: 2018

20. The effects of the time of intranasal splinting on bacterial colonization, postoperative complications, and patient discomfort after septoplasty operations

Author: Mehti Salviz, Abdullah Karatas, Gonul Sengoz, Filiz Pehlivanoglu, Burak Dikmen, Nuray Kuvat, and Isil Taylan Cebi
Subjects: Male, Nasal cavity, medicine.medical_specialty, Time Factors, Adolescent, Splint nasal, medicine.medical_treatment, Perforation (oil well), Postoperative Hemorrhage, Rhinoplasty, Young Adult, 03 medical and health sciences, 0302 clinical medicine, medicine, Nasal septum, Humans, Tampons, Surgical, Nasal splint, Prospective Studies, 030212 general & internal medicine, 030223 otorhinolaryngology, Synechia, Nose, Nasal Septum, Pain, Postoperative, Conforto do paciente, Septoplasty, business.industry, Middle Aged, lcsh:Otorhinolaryngology, equipment and supplies, medicine.disease, lcsh:RF1-547, Surgery, body regions, Septoplastia, stomatognathic diseases, Splints, Patient comfort, medicine.anatomical_structure, Otorhinolaryngology, Anesthesia, Female, Nasal Obstruction, business
Abstract: Introduction The main reason for nasal tampon placement after septoplasty is to prevent postoperative hemorrhage, while the secondary purpose is internal stabilization after operations involving the cartilaginous-bony skeleton of the nose. Silicone intranasal splints are as successful as other materials in controlling postoperative hemorrhages of septal origin. The possibility of leaving the splints intranasally for extended periods helps stabilize the septum in the midline. However, there is nothing in the literature about how long these splints can be retained inside the nasal cavity without increasing the risk of infection, postoperative complications, and patient discomfort. Objective The current study aimed to evaluate the association between the duration of intranasal splinting and bacterial colonization, postoperative complications, and patient discomfort. Methods Patients who had undergone septoplasty were divided into three groups according to the day of removal of the silicone splints. The splints were removed on the fifth, seventh, and tenth postoperative days. The removed splints were microbiologically cultured. Early and late complications were assessed, including local and systemic infections, tissue necrosis, granuloma formation, mucosal crusting, synechia, and septal perforation. Postoperative patient discomfort was evaluated by scoring the levels of pain and nasal obstruction. Results No significant difference was found in the rate of bacterial colonization among the different groups. Decreased mucosal crusting and synechia were detected with longer usage intervals of intranasal silicone splints. Postoperative pain and nasal obstruction were also diminished by the third postoperative day. Conclusions Silicone splints were well tolerated by the patients and any negative effects on postoperative patient comfort were limited. In fact, prolonged splint usage intervals reduced late complications. Long-term silicone nasal splint usage is a reliable, effective, and comfortable method in patients with excessive mucosal damage and in whom long-term stabilization of the bony and cartilaginous septum is essential.
Published: 2016

21. An Evaluation of Hepatitis A Seroprevalence and Vaccination Status in Patients with HIV/AIDS: Data from A 20-year Period

Author: Esra Zerdali, Hatice Kübra Karanalbant, Melike Nur Kültür, İnci Yılmaz Nakir, and Filiz Pehlivanoğlu
Subjects: hepatitis a infection, hiv/aids, vaccination, Medicine
Abstract: Introduction:Hepatitis A infection, caused by the hepatitis A virus (HAV), is a non-chronic disease that can be prevented with vaccination. It is a significant cause of morbidity in adults. Homosexually active males, drug users, the homeless, and prisoners are at a greater risk of HAV infection. This study aimed to determine the hepatitis A seroprevalence and vaccination rates of people living with human immunodeficiency virus (HIV) followed up in our clinic.Methods:A retrospective examination was made of the polyclinic files and laboratory test results in the hospital information system of 1,326 patients aged >18 years, who were diagnosed with HIV/AIDS and followed up in the Infectious Diseases Polyclinic of University of Health Sciences Turkey, Haseki Training and Research Hospital between September 30, 2002 and September 30, 2022.Results:Anti-HAV immunoglobulin G (IgG) positivity was present in 1090 (82.2%) patients. As age increased, anti-HAV IgG positivity also increased, females were significantly more affected, no difference was determined between nationalities, and there was seen to be a significant decrease in the positivity rate over the time period of the study. The positivity rate was determined to be significantly high in heterosexual patients. The hepatitis A vaccination rate was determined to be 16.9%, and serology was examined in 60% of the patients after vaccination. The response to vaccination was determined to be 91.6% in the patients with serology examination.Conclusion:Although improvements in sanitation and vaccination in childhood have provided a decrease in HAV seropositivity, the key populations must be informed about vaccination and vaccination adherence is ensured to prevent small outbreaks.
Published: 2023
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22. Cranial imaging findings in neurobrucellosis: results of Istanbul-3 study

Author: Ayşe Seza Inal, Kaan Meric, Filiz Pehlivanoglu, Meltem Avci, Oğuz Reşat Sipahi, Asuman Inan, Derya Ozturk-Engin, Hanefi Cem Gul, Selçuk Kaya, Esmeray Mutlu-Yilmaz, Selma Tosun, Ayten Kadanali, Sibel Bolukcu, Tumer Guven, Elif Sahin-Horasan, Emel Yilmaz, Abdullah Umut Pekok, Fatma Sirmatel, Canan Agalar, Celal Ayaz, Mustafa Kasim Karahocagil, Ayse Batirel, Hasan Karsen, Secil Deniz, Hakan Erdem, Asli Haykir-Solay, Nefise Oztoprak, Asim Ulcay, Gonul Sengoz, Mahmut Sunnetcioglu, Ayhan Akbulut, Nazif Elaldi, Selma Ates-Guler, Mehmet Ulug, Recep Tekin, Affan Denk, Yasemin Cag, Mustafa Namiduru, Emine Parlak, Sukran Kose, Rodrigo Hasbun, Mustafa Kemal Çelen, Tuna Demirdal, Seniha Senbayrak, Huseyin Turgut, Kadriye Kart Yaşar, Ali İrfan Baran, Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı., Yılmaz, Emel, Çukurova Üniversitesi, [Erdem, Hakan] Gulhane Mil Med Acad, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Senbayrak, Seniha -- Deniz, Secil -- Ozturk-Engin, Derya -- Inan, Asuman] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Meric, Kaan] Haydarpasa Numune Training & Res Hosp, Dept Radiol, Istanbul, Turkey -- [Batirel, Ayse] Dr Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Karahocagil, Mustafa Kasim -- Baran, Ali Irfan -- Sunnetcioglu, Mahmut] Yuzuncu Yil Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Van, Turkey -- [Hasbun, Rodrigo] Univ Texas Hlth Sci Ctr Houston, Sch Med, Dept Infect Dis, Houston, TX 77030 USA -- [Sengoz, Gonul -- Pehlivanoglu, Filiz] Haseki Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Karsen, Hasan] Harran Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sanliurfa, Turkey -- [Kaya, Seluk] Karadeniz Tech Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Trabzon, Turkey -- [Inal, Ayse Seza] Cukurova Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Adana, Turkey -- [Pekok, Abdullah Umut] Private Erzurum Sifa Hosp, Dept Infect Dis & Clin Microbiol, Erzurum, Turkey -- [Celen, Mustafa Kemal -- Tekin, Recep -- Ayaz, Celal] Dicle Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Ulug, Mehmet] Private Umit Hosp, Dept Infect Dis & Clin Microbiol, Eskisehir, Turkey -- [Demirdal, Tuna] Katip Celebi Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Namiduru, Mustafa] Gaziantep Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Gaziantep, Turkey -- [Guven, Tumer] Ankara Atatrk Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Parlak, Emine] Ataturk Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Erzurum, Turkey -- [Bolukcu, Sibel -- Sipahi, Oguz Resat] Bezmi Alem Vakif Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Avci, Meltem -- Tosun, Selma] Izmir Bozyaka Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Yasar, Kadriye] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Yilmaz, Emel] Uludag Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Bursa, Turkey -- [Ates-Guler, Selma] Sutcu Imam Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Kahramanmaras, Turkey -- [Mutlu-Yilmaz, Esmeray] Samsun Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Samsun, Turkey -- [Sirmatel, Fatma] Abant Izzet Baysal Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Bolu, Turkey -- [Sahin-Horasan, Elif] Mersin Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Mersin, Turkey -- [Akbulut, Ayhan -- Denk, Affan] Firat Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Elazig, Turkey -- [Oztoprak, Nefise] Antalya Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Antalya, Turkey -- [Cag, Yasemin] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Kadanali, Ayten] Umraniye Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Turgut, Huseyin] Pamukkale Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Denizli, Turkey -- [Gul, Hanefi Cem -- Ulcay, Asim] GATA Haydarpasa Training Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Haykir-Solay, Asli] Igdir State Hosp, Dept Infect Dis & Clin Microbiol, Igdir, Turkey -- [Kose, Sukran] Tepecik Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Agalar, Canan] Fatih Sultan Mehmet Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Elaldi, Nazif] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey, Inal, Ayse Seza -- 0000-0002-1182-7164, ayaz, celal -- 0000-0002-9060-1090, and Kart Yasar, Kadriye -- 0000-0003-2963-4894
Subjects: Nervous-system brucellosis, Male, Pathology, Turkey, Glucose blood level, 0302 clinical medicine, middle aged, nuclear magnetic resonance imaging, granuloma, brain edema, protein cerebrospinal fluid level, neuroimaging, adult, General Medicine, Case Report, Agglutination Tests, Zoonosis, Nuclear magnetic resonance imaging, aged, Protein cerebrospinal fluid level, Diagnostic imaging, brain infection, Human, Microbiology (medical), medicine.medical_specialty, diagnostic imaging, 030106 microbiology, Major clinical study, Microbiology, Article, 03 medical and health sciences, x-ray computed tomography, Humans, human, lymphocyte count, Polyradiculopathy, radiculopathy, Aged, X-ray computed tomography, microbiology, medicine.disease, major clinical study, Brucella, glucose blood level, Glucose, Arachnoiditis, cerebrospinal fluid level, Brain edema, Lymphocyte count, polyneuropathy, 030217 neurology & neurosurgery, 0301 basic medicine, Physiology, Turkey (republic), computer assisted tomography, Cerebrospinal fluid, Diagnosis, Prevalence, glucose, Radiculopathy, brain disease, CSF albumin, cranial nerve, Cranial nerve, Brain Diseases, Granuloma, Cerebrospinal fluid level, medicine.diagnostic_test, White matter, spinal root, Brain infection, Middle Aged, Magnetic Resonance Imaging, brain abscess, Brain abscess, female, Infectious Diseases, brucellosis, young adult, Female, Neurobrucellosis, hydrocephalus, white matter, Polyneuropathy, Hydrocephalus, Adult, Adolescent, Brain Diseases/diagnostic imaging/*pathology, Brucella/physiology, Brucellosis/diagnostic imaging/*epidemiology/microbiology/pathology, Neuroimaging, Tomography, X-Ray Computed, Turkey/epidemiology, Young Adult, Brucellosis, Cerebral edema, Computer assisted tomography, medicine, controlled study, Meningitis, Brain disease, Inflammation, business.industry, Protein, Magnetic resonance imaging, Computerized tomography, arachnoiditis, physiology, DiagnosisInflammation, pathology, Involvement, protein, Spinal root, business, Controlled study
Abstract: WOS: 000388827200008, PubMed ID: 27138335, Objective Neuroimaging abnormalities in central nervous system (CNS) brucellosis are not well documented. The purpose of this study was to evaluate the prevalence of imaging abnormalities in neurobrucellosis and to identify factors associated with leptomeningeal and basal enhancement, which frequently results in unfavorable outcomes. Methods Istanbul-3 study evaluated 263 adult patients with CNS brucellosis from 26 referral centers and reviewed their 242 magnetic resonance imaging (MRI) and 226 computerized tomography (CT) scans of the brain. Results A normal CT or MRI scan was seen in 143 of 263 patients (54.3 %). Abnormal imaging findings were grouped into the following four categories: (a) inflammatory findings: leptomeningeal involvements (44), basal meningeal enhancements (30), cranial nerve involvements (14), spinal nerve roots enhancement (8), brain abscesses (7), granulomas (6), and arachnoiditis (4). (b) White-matter involvement: white-matter involvement (32) with or without demyelinating lesions (7). (c) Vascular involvement: vascular involvement (42) mostly with chronic cerebral ischemic changes (37). (d) Hydrocephalus/cerebral edema: hydrocephalus (20) and brain edema (40). On multivariate logistic regression analysis duration of symptoms since the onset (OR 1.007; 95 % CI 1-28, p = 0.01), polyneuropathy and radiculopathy (OR 5.4; 95 % CI 1.002-1.013, p = 0.044), cerebrospinal fluid (CSF)/serum glucose rate (OR 0.001; 95 % CI 000-0.067, p = 0.001), and CSF protein (OR 2.5; 95 % CI 2.32.7, p = 0.0001) were associated with diffuse inflammation. Conclusions In this study, 45 % of neurobrucellosis patients had abnormal neuroimaging findings. The duration of symptoms, polyneuropathy and radiculopathy, high CSF protein level, and low CSF/serum glucose rate were associated with inflammatory findings on imaging analyses.
Published: 2016

23. Comparison of brucellar and tuberculous spondylodiscitis patients: results of the multicenter 'Backbone-1 Study'

Author: Tumer Guven, Hakan Erdem, Rehab H. El-Sokkary, Dilara Inan, Serda Gulsun, Fatma Yilmaz-Karadag, Gunay Tuncer-Ertem, Elif Sahin Horasan, Şafak Kaya, Ali İrfan Baran, Recep Tekin, Archontoula Fragou, Seniha Senbayrak, Esra Arslanalp, Fatma Sirmatel, Selçuk Kaya, Ayşe Willke, Salih Cesur, Sani H. Aliyu, Ergys Ramosaco, Meliha Meric-Koc, Meltem Taşbakan, Sukran Kose, Gönül Aslan, Efthymia Giannitsioti, Gonul Sengoz, Haluk Vahaboglu, Nazif Elaldi, Selma Ates-Guler, Birgul Mete, Sesin Kocagöz, Hulya Kusoglu, Ertugrul Guclu, Dilek Yildiz Sevgi, Hava Yilmaz, Gulfem Akengin Ocal, Ayse Batirel, Behiye Dede, Birsen Cetin, Tunc Oktenoglu, D. Ashraf ALGallad, Mehmet Ulug, Sebnem Senol, Banu Karaca, Ilker Inanc Balkan, Aygul Dogan-Celik, Nural Bekiroglu, Gonul Cicek-Senturk, Filiz Pehlivanoglu, Asuman Inan, MERİÇ KOÇ, MELİHA, Erdem, H, Elaldi, N, Batirel, A, Aliyu, S, Sengoz, G, Pehlivanoglu, F, Ramosaco, E, Gulsun, S, Tekin, R, Mete, B, Balkan, II, Sevgi, DY, Giannitsioti, E, Fragou, A, Kaya, S, Cetin, B, Oktenoglu, T, DoganCelik, A, Karaca, B, Horasan, ES, Ulug, M, Man, A, Arslanalp, E, Ates-Guler, S, Willke, A, Senol, S, Inan, D, Guclu, E, Tuncer-Ertem, G, Meric-Koc, M, Tasbakan, M, Senbayrak, S, Cicek-Senturk, G, Sirmatel, F, Ocal, G, Kocagoz, S, Kusoglu, H, Guven, T, Baran, AI, Dede, B, Yilmaz-Karadag, F, Kose, S, Yilmaz, H, Asian, G, Algallad, DA, Cesur, S, El-Sokkary, R, Bekiroglu, N, Vahaboglu, H, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Güçlü, Ertuğrul, [Erdem, Hakan] Culhane Med Acad, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Elaldi, Nazif] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Batirel, Ayse -- Ocal, Gulfem] Dr Lao Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Aliyu, Sani] Cambridge Univ Hosp Fdn Trust, Addenbrookes Hosp, Clin Microbiol & Publ Hlth Lab, Cambridge, England -- [Sengoz, Gonul -- Pehlivanoglu, Filiz] Haseki Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Ramosaco, Ergys] Univ Hosp Ctr Mother Teresa, Infect Dis Hosp, Tirana, Albania -- [Gulsun, Serda -- Kaya, Safak] Diyarbakir Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Tekin, Recep] Dicle Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Mete, Birgul -- Balkan, Ilker Inanc] Istanbul Univ, Cerrahpasa Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Sevgi, Dilek Yildiz] Sisli Etfal Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Giannitsioti, Efthymia -- Fragou, Archontoula] Attikon Univ Gen Hosp, Athens Univ Med Sch, Dept Internal Med, Athens, Greece -- [Kaya, Selcuk] Karadeniz Tech Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Trabzon, Turkey -- [Cetin, Birsen] Koc Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Oktenoglu, Tune] Koc Univ, Sch Med, Dept Neurosurg, Istanbul, Turkey -- [DoganCelik, Aygul] Trakya Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Edirne, Turkey -- [Karaca, Banu] Izmir Bozyaka Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Horasan, Elif Sahin] Mersin Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Mersin, Turkey -- [Ulug, Mehmet] Private Umit Hosp, Dept Infect Dis & Clin Microbiol, Eskisehir, Turkey -- [Man, Asuman -- Senbayrak, Seniha] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Arslanalp, Esra -- Willke, Ayse -- Meric-Koc, Meliha] Kocaeli Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Kocaeli, Turkey -- [Ates-Guler, Selma] Kahramanmaras Sutcu Imam Univ, Sch Med, Dept Infect Dis & Clin Microbiol, TR-46050 Kahramanmaras, Turkey -- [Senol, Sebnem] Celal Bayar Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Manisa, Turkey -- [Inan, Dilara] Akdeniz Univ, Sch Med, Dept Infect Dis & Clin Microbiol, TR-07058 Antalya, Turkey -- [Guclu, Ertugrul] Sakarya Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sakarya, Turkey -- [Tuncer-Ertem, Gunay -- Cesur, Salih] Ankara Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Tasbakan, Meitem] Ege Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Cicek-Senturk, Gonul -- Asian, Gonul] Diskapi Yildirim Beyazit Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Sirmatel, Fatma] Abant Izzet Baysal Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Bolu, Turkey -- [Kocagoz, Sesin -- Kusoglu, Hulya] Acibadem Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Guven, Turner] Ankara Ataturk Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Baran, Ali Irfan] Yuzuncu Yil Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Van, Turkey -- [Dede, Behiye] Umraniye Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Yilmaz-Karadag, Fatma -- Vahaboglu, Haluk] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Kose, Sukran] Tepecik Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Yilmaz, Hava] Ondokuz Mayis Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Samsun, Turkey -- [Algallad, D. Ashraf -- El-Sokkary, Rehab] Zagazig Univ Hosp, Infect Control Unit, Az Zagazig, Egypt -- [Bekiroglu, Nural] Marmara Univ, Sch Med, Dept Biostat, Istanbul, Turkey, VAHABOGLU, Haluk -- 0000-0001-8217-1767, and Ondokuz Mayıs Üniversitesi
Subjects: Adult, Male, Spondylodiscitis, endocrine system, medicine.medical_specialty, Discitis, Constitutional symptoms, Context (language use), Brucellosis, Sequelae, Internal medicine, medicine, Back pain, Humans, Tuberculosis, Orthopedics and Sports Medicine, Abscess, Outcome, Aged, medicine.diagnostic_test, business.industry, Middle Aged, medicine.disease, Surgery, Orthopedics, Erythrocyte sedimentation rate, Female, Neurology (clinical), medicine.symptom, Complication, business
Abstract: WOS: 000366655100045, PubMed ID: 26386176, BACKGROUND CONTEXT: No direct comparison between brucellar spondylodiscitis (BSD) and tuberculous spondylodiscitis (TSD) exists in the literature. PURPOSE: This study aimed to compare directly the clinical features, laboratory and radiological aspects, treatment, and outcome data of patients diagnosed as BSD and TSD. STUDY DESIGN: A retrospective, multinational, and multicenter study was used. PATIENT SAMPLE: A total of 641 (TSD, 314 and BSD, 327) spondylodiscitis patients from 35 different centers in four countries (Turkey, Egypt, Albania, and Greece) were included. OUTCOME MEASURES: The pre- and peri- or post-treatment spinal deformity and neurologic deficit parameters, and mortality were carried out. METHODS: Brucellar spondylodiscitis and TSD groups were compared for demographics, clinical, laboratory, radiological, surgical interventions, treatment, and outcome data. The Student t test and Mann-Whitney U test were used for group comparisons. Significance was analyzed as two sided and inferred at 0.05 levels. RESULTS: The median baseline laboratory parameters including white blood cell count, C-reactive protein, and erythrocyte sedimentation rate were higher in TSD than BSD (p
Published: 2015

24. Assessment of Interest of Healthcare Employees in Distance Training in the Coronavirus Disease-2019 Pandemic Process

Author: Arzu Kaplanoğlu, Gönül Şengöz, Filiz Pehlivanoğlu, Öznur Yıldırım, and Yeşim Kanıpek
Subjects: covid-19, distance training, healthcare employees, pandemic, Medicine
Abstract: Introduction:In-service healthcare personnel training is an ongoing process. However, emerging unknowns require momentary planning. The Coronavirus disease-2019 (COVID-19) pandemic has made distance training (DT) compulsory for healthcare employees (HE). Thus, it is important to learn about their interest levels. This study investigates the interest of HE in DT during the pandemic process.Methods:The research population consisted of 3,442 personnel registered to take the “HE COVID-19” training at research and training hospital in 2020. The population of the study consisted of all personnel employed at research and training hospital and registered for the training. The study was planned retrospectively for reaching all personnel whose training registrations were made between 17.03.2020 and 15.04.2020. This study was used the data of the personnel who completed the “HE COVID-19 Training” within the scope of the announcements that were made as DT as reported on the Hospital Training System.Results:The total training completion rate of the participants was found to be 90%. When the interests of the HE in the DT in the process of the COVID-19 pandemic were compared, no statistically significant difference could be observed in the participation rates of the specialist doctors, resident doctors, and nurses (p=0.094). The rate of the resident doctors to complete the training until the second announcement was significantly lower compared to the specialist doctors and nurses (specialist doctor vs. resident doctor p=0.044; nurse vs. resident doctor p
Published: 2023
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25. Evaluation of the Survey Results Concerning Sharps Injuries

Author: Gonul Sengoz, Sinem Akkaya, Seyda Akkaya-Tek, Emine Gungor-Ozdemir, and Filiz Pehlivanoglu
Subjects: Microbiology (medical), medicine.medical_specialty, Infectious Diseases, business.industry, Family medicine, medicine, Survey result, business
Published: 2015

26. Tuberculous and brucellosis meningitis differential diagnosis

Author: Sibel Bolukcu, Asli Haykir-Solay, Fatma Sirmatel, Melanie Catroux, Secil Deniz, Recep Tekin, Huseyin Turgut, Nefise Oztoprak, Hakan Erdem, Saygin Nayman-Alpat, Levent Gorenek, Selçuk Kaya, Serap Gencer, Meltem Avci, Mahmut Sunnetcioglu, Mustafa Namiduru, Mehmet Ulug, Kadriye Kart Yaşar, Gokhan Karaahmetoglu, Yves Hansmann, Tumer Guven, Rok Čivljak, Tuna Demirdal, Celal Ayaz, Mustafa Kemal Çelen, Isik Somuncu Johansen, Ayse Batirel, Ayten Kadanali, Oğuz Reşat Sipahi, Gonul Sengoz, Emel Yilmaz, Rodrigo Hasbun, Selma Ates-Guler, Ali İrfan Baran, Yasemin Cag, Hasan Karsen, Affan Denk, Emine Parlak, Ayşe Seza Inal, Filiz Pehlivanoglu, Hanefi Cem Gul, Ayhan Akbulut, Elif Sahin-Horasan, Soline Simeon, Seniha Senbayrak, Esmeray Mutlu-Yilmaz, Sukran Kose, Selma Tosun, Abdullah Umut Pekok, Mustafa Kasim Karahocagil, and Çukurova Üniversitesi
Subjects: Adult, Male, medicine.medical_specialty, Tuberculosis, Scoring system, Turkey, retrospective study, urologic and male genital diseases, Article, Brucellosis, Tuberculous meningitis, Meningitis, Bacterial, Diagnosis, Differential, Young Adult, Internal medicine, differential diagnosis, middle aged, Diagnosis, medicine, Humans, agglutination test, controlled study, Meningitis, human, Retrospective Studies, business.industry, Public Health, Environmental and Occupational Health, meningoencephalitis, scoring system, Meningoencephalitis, medicine.disease, major clinical study, Surgery, female, Infectious Diseases, priority journal, tuberculous meningitis, Tuberculosis, Meningeal, Etiology, Differential diagnosis, business, cerebrospinal fluid culture
Abstract: PubMedID: 25801665 SummaryBackground The Thwaites and Lancet scoring systems have been used in the rapid diagnosis of tuberculous meningitis (TBM). However, brucellar meningoencephalitis (BME) has similar characteristics with TBM. The ultimate aim of this study is to infer data to see if BME should be included in the differential diagnosis of TBM when these two systems suggest the presence of TBM. Method BME and TBM patients from 35 tertiary hospitals were included in this study. Overall 294 adult patients with BME and 190 patients with TBM were enrolled. All patients involved in the study had microbiological confirmation for either TBM or BME. Finally, the Thwaites and Lancet scoring systems were assessed in both groups. Results The Thwaites scoring system more frequently predicted BME cases (n = 292, 99.3%) compared to the TBM group (n = 182, 95.8%) (P = 0.017). According to the Lancet scoring system, the mean scores for BME and TBM were 9.43 ± 1.71 and 11.45 ± 3.01, respectively (P < 0.001). In addition, TBM cases were classified into "probable" category more significantly compared to BME cases, and BME cases were categorized into the "possible" category more frequently. Conclusions When the Thwaites or Lancet scoring systems indicate TBM, brucellar etiology should also be taken into consideration particularly in endemic countries. © 2015 Elsevier Ltd. All rights reserved.
Published: 2015

27. Hyperbilirubinemia; Current Causes, Causal Risk Factors and Endpoints

Author: Gonul Sengoz, Filiz Pehlivanoglu, and Mehtap Şimşek
Subjects: medicine.medical_specialty, business.industry, Hepatitis A, Autoimmune hepatitis, Hepatitis B, medicine.disease, Hepatitis E, Gastroenterology, Leptospirosis, Transplantation, Internal medicine, medicine, Etiology, business, Viral hepatitis
Abstract: OZET Objectives: Hyperbilirubinemia has a broad spectrum of causes ranging from benign lifethreatening. Classification of hyperbilirubinemia as prehepatic, hepatic and posthepatic promotes detecting its etiology. Materials and Methods: In this study, we analyzed the diagnoses, etiological risk factors and endpoints in 60 patients with hyperbilirubinemia. Inclusion criteria included moderate-bad general condition, enzyme levels >2000 U/L, bilirubin levels >5 mg/dL, impaired coagulation parameters and fever and rashes. Age, gender, etiology, contamination patterns, physical examination, laboratory findings and prognosis were analyzed retrospectively. Results: The diagnoses of the diseases based on their incidence were hepatitis B (n=34), hepatitis A (n=12), activation of chronic HBV infection (n=5), autoimmune hepatitis (n=2), malaria (n=2), hepatitis E (n=1), leptospirosis (n=1) and liver abscess (n=1). Mean age and female/male distribution ratio for viral hepatitis were 33 and 1/2, respectively. When risk factors were questioned; risk factors could not be identified in 69% of patients with viral hepatitis. Use of municipal water was found in history of 17% cases with hepatitis A whereas history of suspected sexual contact and dental treatment were found in 26% and 17% of patients with hepatitis B. Intrafamilial contamination was found in seven cases. Bicytopenia and monocytosis were observed in 15% and 84% of subjects. The mean bilirubin value was 16 mg/ dL with the highest value of 44.6 mg/dL. The highest ALT were averagely 3170 U/L and 2891 U/L in patients with hepatitis A and B, respectively. Two patients became exitus while one patient was referred to an external center for transplantation. The diagnoses in those three patients were hepatitis B and autoimmune hepatitis. Conclusion: Although, joundice is related with many diseases, in Turkey, it is most commonly associated with viral hepatitis. (Viral Hepatitis Journal 2014; 20(3): 87-90)
Published: 2014

28. Influence of multidrug resistant organisms on the outcome of diabetic foot infection

Author: Nazan Tuna, Mucahit Yemisen, Filiz Pehlivanoglu, Oguz Karabay, Buket Erturk, Necla Tulek, Omer Coskun, Fatma Yilmaz, Nuray Uzun, Yasar Kucukardali, Nurgul Ceran, Kadriye Kart Yaşar, Oznur Ak, Turan Aslan, Taner Yildirmak, Nail Ozgunes, Lutfiye Mulazimoglu, Atahan Cagatay, Tuna Demirdal, Ayse Batirel, Fatma Sargin, Haluk Eraksoy, Ayten Kadanali, Gulsen Yoruk, Salih Atakan Nemli, Derya Öztürk, Oral Oncul, Gül Karagöz, Onder Ergonul, Nese Saltoglu, Yasemin Akkoyunlu, Meral Sonmezoglu, Hakan Ay, Cagla Sonmezer, Funda Şimşek, Gonul Sengoz, Serkan Surme, Ergönül, Mehmet Önder (ORCID 0000-0003-1935-9235 & YÖK ID 110398), Saltoğlu, Neşe, Tülek, Necla, Yemisen, Mücahit, Kadanalı, Ayten, Karagöz, Gül, Batırel, Ayşe, Ak, Öznür, Sönmezer, Cağla, Eraksoy, Haluk, Cağatay, Atahan, Sürme, Serkan, Nemli, Salih A., Demirdal, Tuna, Coşkun, Ömer, Öztürk, Derya, Ceran, Nurgül, Pehlivanoğlu, Filiz, Şengoz, Gönül, Aslan, Turan, Akkoyunlu, Yasemin, Öncül, Oral, Ay, Hakan, Mülazımoğlu, Lütfiye, Ertürk, Buket, Yılmaz, Fatma, Yörük, Gülşen, Uzun, Nuray, Şimşek, Funda, Yıldırmak, Taner, Yaşar, Kadriye Kart, Sönmezoğlu, Meral, Küçükkardalı, Yaşar, Tuna, Nazan, Karabay, Oğuz, Özgüneş, Nail, Sargın, Fatma, School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Saltoglu, Nese, Ergonul, Onder, Tulek, Necla, Yemisen, Mucahit, Kadanali, Ayten, Karagoz, Gul, Batirel, Ayse, Ak, Oznur, Sonmezer, Cagla, Cagatay, Atahan, Surme, Serkan, Coskun, Omer, Ozturk, Derya, Ceran, Nurgul, Pehlivanoglu, Filiz, Sengoz, Gonul, Akkoyunlul, Yasemin, Oncul, Oral, Mulazimoglu, Lutfiye, Erturk, Buket, Yilmaz, Fatma, Yoruk, Gulsen, Simsek, Funda, Yildirmak, Taner, Yasar, Kadriye Kart, Sonmezoglu, Meral, kucukardali, Yasar, Karabay, Oguz, Ozgunes, Nail, Sargin, Fatma, and AKKOYUNLU, YASEMİN
Subjects: Male, Klebsiella, genetic structures, IMPACT, Klebsiella pneumoniae, MRSA, medicine.disease_cause, SOFT-TISSUE INFECTIONS, 0302 clinical medicine, Diabetic foot infection, 030212 general & internal medicine, Aged, 80 and over, biology, Fatality, Osteomyelitis, General Medicine, Middle Aged, Diabetic Foot, Drug Resistance, Multiple, Anti-Bacterial Agents, ULCERS, TRIALS, Infectious Diseases, Staphylococcus aureus, Pseudomonas aeruginosa, Infectious diseases, Female, Microbiology (medical), Adult, medicine.medical_specialty, SOCIETY, 030209 endocrinology & metabolism, ANTIBIOTIC-THERAPY, Patient Readmission, Amputation, Surgical, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Internal medicine, medicine, Escherichia coli, Humans, lcsh:RC109-216, STAPHYLOCOCCUS-AUREUS, Aged, business.industry, medicine.disease, biology.organism_classification, Diabetic foot, Multiple drug resistance, Patient Outcome Assessment, TURKEY, RISK-FACTORS, business, Staphylococcus, Saltoglu N., Ergonul O., TULEK N., Yemisen M., KADANALI A., KARAGOZ G., BATIREL A., AK O., SONMEZER C., Eraksoy H., et al., -Influence of multidrug resistant organisms on the outcome of diabetic foot infection-, INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, cilt.70, ss.10-14, 2018
Abstract: Objectives: We described the clinical outcomes of the diabetic patients who had foot infections with multidrug resistant organisms. Methods: We included the patients with diabetic foot infections (DFI) from 19 centers, between May 2011 and December 2015. Infection was defined according to IDSA DFI guidelines. Patients with severe infection, complicated moderate infection were hospitalized. The patients were followed-up for 6 months after discharge. Results: In total, 791 patients with DFI were included, 531(67%) were male, median age was 62 (19-90). Severe infection was diagnosed in 85 (11%) patients. Osteomyelitis was diagnosed in 291(36.8%) patients. 536 microorganisms were isolated, the most common microorganisms were S. aureus (20%), P. aeruginosa (19%) and E. coli (12%). Methicillin resistance (MR) rate among Staphylococcus aureus isolates was 31%. Multidrug resistant bacteria were detected in 21% of P. aeruginosa isolates. ESBL (+) Gram negative bacteria (GNB) was detected in 38% of E. coli and Klebsiella isolates. Sixty three patients (8%) were rehospitalized. Of the 791 patiens, 127 (16%) had major amputation, and 24 (3%) patients died. In multivariate analysis, significant predictors for fatality were; dialysis (OR: 8.3, Cl: 1.82-38.15, p = 0.006), isolation of Klebsiella spp. (OR:7.7, Cl: 1.24-47.96, p = 0.028), and chronic heart failure (OR: 3, Cl: 1.01-9.04, p = 0.05). MR Staphylococcus was detected in 21% of the rehospitalized patients, as the most common microorganism (p < 0.001). Conclusion: Among rehospitalized patients, methicillin resistant Staphylococcus infections was detected as the most common agent, and Klebsiella spp. infections were found to be significantly associated with fatality. (C) 2018 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
Published: 2017

29. Miliary tuberculosis Epidemiologicaland clinical analysis of large-case series from moderate to low tuberculosis endemic Country

Author: Demet Turan, Ayse Batirel, Mesut Yilmaz, Emine Nur Koç, Recep Tekin, Behice Kurtaran, Süheyla Kömür, Ilker Inanc Balkan, Ilyas Dokmetas, Osman Hayran, Ferhat Arslan, Tuna Demirdal, Ali Mert, Bahadir Ceylan, Özlem Güzel Tunçcan, Emine Parlak, Tulin Kuyucu, Sedat Altin, Oğuz Reşat Sipahi, Filiz Pehlivanoglu, Gonul Sengoz, Hüseyin Aytaç Erdem, Dilek Yildiz, İstanbul Medipol Üniversitesi, Tıp Fakültesi, Ege Üniversitesi, and Çukurova Üniversitesi
Subjects: medicine.medical_specialty, Miliary tuberculosis, Tuberculosis, Anemia, Tuberculin, 030204 cardiovascular system & hematology, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diagnosis, medicine, 030212 general & internal medicine, Fever of unknown origin, medicine.diagnostic_test, business.industry, General Medicine, medicine.disease, Prognosis, Pancytopenia, Surgery, Miliary Tuberculosis, Erythrocyte sedimentation rate, Sputum, medicine.symptom, business
Abstract: WOS: 000394253800016, PubMed ID: 28151863, The aim of this study was to determine the clinical features, and outcome of the patients with miliary tuberculosis (TB). We retrospectively evaluated 263 patients (142 male, 121 female, mean age: 44 years, range: 16-89 years) with miliary TB. Criteria for the diagnosis of miliary TB were at least one of the followings in the presence of clinical presentation suggestive of miliary TB such as prolonged fever, night sweats, anorexia, weight loss: radiologic criterion and pathological criterion and/or microbiological criterion; pathological criterion and/or microbiological criterion. The miliary pattern was seen in 88% of the patients. Predisposing factors were found in 41% of the patients. Most frequent clinical features and laboratory findings were fever (100%), fatigue (91%), anorexia (85%), weight loss (66%), hepatomegaly (20%), splenomegaly (19%), choroid tubercules (8%), anemia (86%), pancytopenia (12%), and accelerated erythrocyte sedimentation rate (89%). Tuberculin skin test was positive in 29% of cases. Fifty percent of the patients met the criteria for fever of unknown origin. Acid-fast bacilli were demonstrated in 41% of patients (81/195), and cultures for Mycobacterium tuberculosis were positive in 51% (148/292) of tested specimens (predominantly sputum, CSF, and bronchial lavage). Blood cultures were positive in 20% (19/97). Granulomas in tissue samples of liver, lung, and bone marrow were present in 100% (21/21), 95% (18/19), and 82% (23/28), respectively. A total of 223 patients (85%) were given a quadruple anti-TB treatment. Forty-four (17%) patients died within 1 year after diagnosis established. Age, serum albumin, presence of military pattern, presence of mental changes, and hemoglobin concentration were found as independent predictors of mortality. Fever resolved within first 21 days in the majority (90%) of the cases. Miliary infiltrates on chest X-ray should raise the possibility of miliary TB especially in countries where TB is endemic. Although biopsy of the lungs and liver may have higher yield rate of organ involvement histopathologicaly, less invasive procedures including a bone marrow biopsy and blood cultures should be preferred owing to low complication rates.
Published: 2017

30. Tetanus in adults:results of the multicenter ID-IRI study

Author: Firdevs Aksoy, Serpil Erol, Ayse Batirel, Selma Tosun, Emine Parlak, S Dirgen-Caylak, Serkan Oncu, Kadriye Kart-Yasar, Filiz Pehlivanoglu, Güven Çelebi, Asuman Inan, Edmond Puca, Tansu Yamazhan, Aliye Esmaoğlu, Signe Maj Sørensen, Recep Tekin, Ayse Sagmak-Tartar, Lenka Baštáková, Aliye Bastug, Ergenekon Karagoz, Serap Ural, A I Oluk, Yasemin Cag, Meliha Meric-Koc, Hakan Erdem, Pierre Tattevin, Rahmet Guner, Saygin Nayman-Alpat, Gonul Sengoz, François Bénézit, Affan Denk, V. Koksaldi-Motor, Habip Gedik, MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Dirgen Çaylak, Selmin, and Zonguldak Bülent Ecevit Üniversitesi
Subjects: Microbiology (medical), Adult, Male, medicine.medical_specialty, Adolescent, 030231 tropical medicine, Risk Assessment, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Medical microbiology, Internal medicine, medicine, Journal Article, Animals, Humans, 030212 general & internal medicine, Leukocytosis, Young adult, Survival analysis, Aged, Retrospective Studies, Aged, 80 and over, Tetanus, business.industry, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, Prognosis, Survival Analysis, Surgery, Hospitalization, Infectious Diseases, Immunization, Female, medicine.symptom, business, Risk assessment
Abstract: Tetanus is an acute, severe infection caused by a neurotoxin secreting bacterium. Various prognostic factors affecting mortality in tetanus patients have been described in the literature. In this study, we aimed to analyze the factors affecting mortality in hospitalized tetanus patients in a large case series. This retrospective multicenter study pooled data of tetanus patients from 25 medical centers. The hospitals participating in this study were the collaborating centers of the Infectious Diseases International Research Initiative (ID-IRI). Only adult patients over the age of 15 years with tetanus were included. The diagnosis of tetanus was made by the clinicians at the participant centers. Izmir Bozyaka Education and Research Hospital’s Review Board approved the study. Prognostic factors were analyzed by using the multivariate regression analysis method. In this study, 117 adult patients with tetanus were included. Of these, 79 (67.5%) patients survived and 38 (32.5%) patients died. Most of the deaths were observed in patients >60 years of age (60.5%). Generalized type of tetanus, presence of pain at the wound area, presence of generalized spasms, leukocytosis, high alanine aminotransferase (ALT) and C-reactive protein (CRP) values on admission, and the use of equine immunoglobulins in the treatment were found to be statistically associated with mortality (p < 0.05 for all). Here, we describe the prognostic factors for mortality in tetanus. Immunization seems to be the most critical point, considering the advanced age of our patients. A combination of laboratory and clinical parameters indicates mortality. Moreover, human immunoglobulins should be preferred over equine sera to increase survival. © 2017, Springer-Verlag Berlin Heidelberg.
Published: 2017

31. Mount Fuji Sign: A Rare Complication of Meningitis

Author: Mustafa Ali Akçetin, Gonul Sengoz, and Filiz Pehlivanoglu
Subjects: medicine.medical_specialty, lcsh:R5-920, business.industry, Mount Fuji sign, lcsh:R, meningitis, lcsh:Medicine, General Medicine, medicine.disease, Surgery, Medicine, lumbar puncture, pneumocephalus, Complication, business, lcsh:Medicine (General), Meningitis, Sign (mathematics)
Abstract: Acute bacterial meningitis is a critical condition also because of associated complications and sequelae besides being a life-threatening infection. The complications may develop due to disease itself, diagnostic procedures or treatment. Pneumocephaly is defined as the presence of air in the cranial cavity. Pneumocephalus of spinal origin may be associated with spinal trauma, penetrating injury, tumors, and infections resulting from iatrogenic causes such as lumbar puncture. Here, we present a case of a 22-year-old male with the diagnosis of acute bacterial meningitis in whom pneumocephalus occurred after lumbar puncture. In this study, we aimed to draw attention to a rare complication of lumbar puncture.
Published: 2018

32. The Relations between Slime Factor Positivity, Methicillin and Antibiotic Resistance in Staphylococci

Author: Yesim Aybar Bilir, Gonul Sengoz, Filiz Pehlivanoglu, and Kadriye Kart Yaşar
Subjects: Antibiotic resistance, business.industry, General Engineering, Medicine, business, Microbiology
Published: 2012

33. Managing atypical and typical herpetic central nervous system infections: results of a multinational study

Author: Signe Maj Sørensen, Jean-Paul Stahl, Seher Ayten Coskuner, Pierre Tattevin, Mauro Maresca, Sibel Bolukcu, Oğuz Reşat Sipahi, Rosa Fontana, Lykke Larsen, Xavier Argemi, Lenka Baštáková, Guillaume Béraud, Mario Poljak, Gamze Kilicoglu, Matjaž Jereb, Bruno Baršić, Akram Al-Mahdawi, Nevin Ince, Isik Somuncu Johansen, Filiz Pehlivanoglu, Sylviane Defres, Hasan Karsen, Yasemin Akkoyunlu, Asuman Inan, Souha S. Kanj, Hava Yilmaz, Nazif Elaldi, Elif Sahin-Horasan, Jesper Damsgaard Gunst, Emine Parlak, Hulya Tireli, Hakan Erdem, Anne Lisbeth Bohr, Fatime Korkmaz, Oguz Karabay, Haluk Vahaboglu, Gulden Yilmaz, Ghaydaa A. Shehata, Süheyla Kömür, Stephen L. Leib, Mahtab Chehri, Salih Atakan Nemli, Abdullah Umut Pekok, Sukran Kose, Derya Ozturk-Engin, Seniha Senbayrak, Mehmet Ulug, Gulistan Halac, Mustafa Sunbul, Gonul Sengoz, Selçuk Kaya, Ahmad Sharif-Yakan, Yasemin Cag, Institute of Microbiology and Immunology, Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], CHU Pontchaillou [Rennes], Fonction, structure et inactivation d'ARN bactériens, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre Hospitalier Universitaire [Grenoble] (CHU), Cumhuriyet Universitesi, AKKOYUNLU, YASEMİN, Institute of Microbiology and Immunology - Inštitut za mikrobiologijo in imunologijo [Ljubljana, Slovenia], Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Ege Üniversitesi, [Cag, Y.] Dr Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Erdem, H.] Gulhane Mil Med Acad, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Leib, S.] Univ Bern, Inst Infect Dis, CH-3012 Bern, Switzerland -- [Defres, S.] Univ Liverpool, Inst Infect & Global Hlth, Liverpool L69 3BX, Merseyside, England -- [Defres, S.] Royal Liverpool & Broadgreen Univ Hosp NHS Trust, Trop Infect Dis Unit, Liverpool, Merseyside, England -- [Kaya, S.] Karadeniz Tech Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Trabzon, Turkey -- [Larsen, L. -- Johansen, I. S.] Odense Univ Hosp, Dept Infect Dis Q, Odense, Denmark -- [Poljak, M.] Univ Ljubljana, Inst Microbiol & Immunol, Fac Med, Ljubljana, Slovenia -- [Ozturk-Engin, D. -- Bolukcu, S. -- Inan, A. -- Senbayrak, S.] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Barsic, B.] Univ Zagreb, Dr Fran Mihaljev Univ Hosp Infect Dis, Dept Infect Dis, Sch Med, Zagreb, Croatia -- [Argemi, X.] Nouvel Hop Civil, Dept Infect Dis, Strasbourg, France -- [Sorensen, S. M.] Aalborg Univ Hosp, Dept Infect Dis, Aalborg, Denmark -- [Bohr, A. L.] Rigshosp, Copenhagen Univ Hosp, Inst Inflammat Res, Dept Infect Dis & Rheumatol, Copenhagen, Denmark -- [Tattevin, P.] Univ Hosp Pontchaillou, Dept Infect & Trop Dis, Rennes, France -- [Gunst, J. D.] Aarhus Univ Hosp, Dept Infect Dis, Aarhus, Denmark -- [Bastakova, L.] Masaryk Univ, Fac Hosp Brno, Dept Infect Dis, Fac Med, Brno, Czech Republic -- [Jereb, M.] Univ Med Ctr, Dept Infect Dis, Ljubljana, Slovenia -- [Karabay, O.] Sakarya Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Sakarya, Turkey -- [Pekok, A. U.] Private Erzurum Sifa Hosp, Dept Infect Dis & Clin Microbiol, Erzurum, Turkey -- [Sipahi, O. R.] Ege Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Izmir, Turkey -- [Chehri, M.] Hvidovre Univ Hosp, Dept Infect Dis, Copenhagen, Denmark -- [Beraud, G.] Univ Poitiers Hosp, Dept Infect Dis, Poitiers, France -- [Shehata, G.] Assiut Univ Hosp, Dept Neurol & Psychiat, Assiut, Egypt -- [Fontana, R. -- Maresca, M.] Univ Catania, Infect Dis Sect, Dept Clin & Mol Biomed, Catania, Italy -- [Karsen, H.] Harran Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sanliurfa, Turkey -- [Sengoz, G. -- Pehlivanoglu, F.] Haseki Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Sunbul, M. -- Yilmaz, H.] Ondokuz Mayis Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Samsun, Turkey -- [Yilmaz, G.] Ankara Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Sharif-Yakan, A. -- Kanj, S.] Amer Univ Beirut, Med Ctr, Beirut, Lebanon -- [Parlak, E.] Ataturk Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Erzurum, Turkey -- [Korkmaz, F.] Konya Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Konya, Turkey -- [Komur, S.] Cukurova Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Adana, Turkey -- [Kose, S.] Tepecik Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Ulug, M.] Private Umit Hosp, Dept Infect Dis & Clin Microbiol, Eskisehir, Turkey -- [Coskuner, S. A.] Izmir Bozyaka Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Stahl, J. P.] Univ Grenoble 1, Grenoble, France -- [Stahl, J. P.] Univ Hosp Grenoble, Dept Infect Dis, Grenoble, France -- [Ince, N.] Duzce Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Duzce, Turkey -- [Akkoyunlu, Y.] Bezmi Alem Vakif Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Halac, G.] Bezmi Alem Vakif Univ, Sch Med, Dept Neurol, Istanbul, Turkey -- [Sahin-Horasan, E.] Mersin Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Mersin, Turkey -- [Tireli, H.] Haydarpasa Numune Training & Res Hosp, Dept Neurol, Istanbul, Turkey -- [Kilicoglu, G.] Haydarpasa Numune Training & Res Hosp, Dept Radiol, Istanbul, Turkey -- [Al-Mahdawi, A.] Baghdad Teaching Hosp, Dept Neurol, Baghdad, Iraq -- [Nemli, S. A.] Katip Celebi Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Izmir, Turkey -- [Vahaboglu, H.] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Elaldi, N.] Cumhuriyet Univ, Dept Infect Dis & Clin Microbiol, Sch Med, Sivas, Turkey, Ghaydaa, Shehata -- 0000-0002-3631-893X, VAHABOGLU, Haluk -- 0000-0001-8217-1767, Kanj, Souha -- 0000-0001-6413-3396, Beraud, Guillaume -- 0000-0002-4705-0916, Gunst, Jesper -- 0000-0002-3787-0259, Stahl, Jean Paul -- 0000-0002-0086-3557, johansen, isik somuncu -- 0000-0002-2189-9823, Larsen, Lykke -- 0000-0002-4113-4182, Karabay, Oguz -- 0000-0003-0502-432X, OMÜ, Cag, Y, Erdem, H, Leib, S, Defres, S, Kaya, S, Larsen, L, Poljak, M, Ozturk-Engin, D, Barsic, B, Argemi, X, Sorensen, SM, Bohr, AL, Tattevin, P, Gunst, JD, Bastakova, L, Jereb, M, Johansen, IS, Karabay, O, Pekok, AU, Sipahi, OR, Chehri, M, Beraud, G, Shehata, G, Fontana, R, Maresca, M, Karsen, H, Sengoz, G, Sunbul, M, Yilmaz, G, Yilmaz, H, Sharif-Yakan, A, Kanj, S, Parlak, E, Pehlivanoglu, F, Korkmaz, F, Komur, S, Kose, S, Ulug, M, Bolukcu, S, Coskuner, SA, Stahl, JP, Ince, N, Akkoyunlu, Y, Halac, G, Sahin-Horasan, E, Tireli, H, Kilicoglu, G, Al-Mahdawi, A, Nemli, SA, Inan, A, Senbayrak, S, Vahaboglu, H, Elaldi, N, Sakarya Üniversitesi/İlahiyat Fakültesi/Temel İslam Bilimleri Bölümü, Kaya, Süleyman, Karabay, Oğuz, and Çukurova Üniversitesi
Subjects: Male, Pathology, [SDV]Life Sciences [q-bio], encephalitis, Electroencephalography, medicine.disease_cause, Polymerase Chain Reaction, 0302 clinical medicine, Cerebrospinal fluid, 030212 general & internal medicine, Cerebrospinal Fluid, Aged, 80 and over, medicine.diagnostic_test, Atypical presentation, Brain, meningitis, General Medicine, Middle Aged, Magnetic Resonance Imaging, 3. Good health, Infectious Diseases, medicine.anatomical_structure, results of a multinational study-, Clinical Microbiology And Infection, cilt.22, ss.568-569, 2016 [Akkoyunlu Y., Çağ Y., -Managing atypical and typical herpetic central nervous system infections], Female, Presentation (obstetrics), Encephalitis, Adult, Microbiology (medical), medicine.medical_specialty, Adolescent, Central nervous system, Microbiology, Young Adult, 03 medical and health sciences, Internal medicine, medicine, Journal Article, Humans, Aged, Retrospective Studies, managing, Diagnostic Tests, Routine, business.industry, Magnetic resonance imaging, medicine.disease, herpes simplex virus, Herpes simplex virus, Concomitant, DNA, Viral, Encephalitis, Herpes Simplex, business, 030217 neurology & neurosurgery
Abstract: WOS: 000379252100027, PubMed ID: 27085724, There have been many studies pertaining to the management of herpetic meningoencephalitis (HME), but the majority of them have focussed on virologically unconfirmed cases or included only small sample sizes. We have conducted a multicentre study aimed at providing management strategies for HME. Overall, 501 adult patients with PCR-proven HME were included retrospectively from 35 referral centres in 10 countries; 496 patients were found to be eligible for the analysis. Cerebrospinal fluid (CSF) analysis using a PCR assay yielded herpes simplex virus (HSV)-1 DNA in 351 patients (70.8%), HSV-2 DNA in 83 patients (16.7%) and undefined HSV DNA type in 62 patients (12.5%). A total of 379 patients (76.4%) had at least one of the specified characteristics of encephalitis, and we placed these patients into the encephalitis presentation group. The remaining 117 patients (23.6%) had none of these findings, and these patients were placed in the nonencephalitis presentation group. Abnormalities suggestive of encephalitis were detected in magnetic resonance imaging (MRI) in 83.9% of the patients and in electroencephalography (EEG) in 91.0% of patients in the encephalitis presentation group. In the nonencephalitis presentation group, MRI and EEG data were suggestive of encephalitis in 33.3 and 61.9% of patients, respectively. However, the concomitant use of MRI and EEG indicated encephalitis in 96.3 and 87.5% of the cases with and without encephalitic clinical presentation, respectively. Considering the subtle nature of HME, CSF HSV PCR, EEG and MRI data should be collected for all patients with a central nervous system infection. (C) 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Published: 2016

34. Hydrocephalus and vasculitis delay therapeutic responses in tuberculous meninigitis: Results of Haydarpasa-III study

Author: Serpil Erol, Canan Agalar, Serkan Oncu, Seniha Senbayrak, Alper Şener, Mihai Nechifor, Gorana Dragovac, Muge Ozguler, Bahar Kandemir, Özcan Deveci, Alexandru Crisan, Rodrigo Hasbun, Nazif Elaldi, Recep Tekin, Gamze Kilicoglu, Hulya Tireli, Kadriye Kart Yaşar, Nurgul Ceran, Aysegul Ulu-Kilic, Oğuz Reşat Sipahi, Gürkan Mert, Derya Ozturk-Engin, Rok Čivljak, Branislava Savic, Katell Andre, Yasemin Cag, Mustafa Namiduru, Mustafa Sunbul, Gonul Sengoz, Oral Oncul, Hakan Erdem, Ayhan Akbulut, Serap Gencer, Selma Alabay, Ayşe Seza Inal, Mucahit Yemisen, Filiz Pehlivanoglu, Olga Dulovic, Asuman Inan, B. Lakatos, Hanefi Cem Gul, Ondokuz Mayıs Üniversitesi, Çukurova Üniversitesi, [Cag, Yasemin] Istanbul Medeniyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Ozturk-Engin, Derya -- Ceran, Nurgul -- Kilicoglu, Gamze -- Tireli, Hulya -- Senbayrak, Seniha -- Inan, Asuman -- Erol, Serpil] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Gencer, Serap] Dr Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Hasbun, Rodrigo] Univ Texas Hlth Sci Ctr Houston, Sch Med, Dept Infect Dis, Houston, TX 77030 USA -- [Sengoz, Gonul -- Pehlivanoglu, Filiz] Haseki Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Crisan, Alexandru] Victor Babes Univ Med & Pharm, Dept Infect Dis, Timisoara, Romania -- [Savic, Branislava] Univ Belgrade, Inst Microbiol & Immunol, Natl Reference Lab TB, Fac Med, Belgrade, Serbia -- [Yasar, Kadriye] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Inal, Ayse S.] Cukurova Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Adana, Turkey -- [Civljak, Rok] Univ Zagreb, Sch Med, Dr Fran Mihaljev Univ Hosp Infect Dis, Dept Infect Dis, Zagreb, Croatia -- [Tekin, Recep -- Deveci, Ozcan] Dicle Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Elaldi, Nazif] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Ulu-Kilic, Aysegul -- Alabay, Selma] Erciyes Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Kayseri, Turkey -- [Ozguler, Muge -- Akbulut, Ayhan] Firat Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Elazig, Turkey -- [Namiduru, Mustafa] Gaziantep Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Gaziantep, Turkey -- [Sunbul, Mustafa] Ondokuz Mayis Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Samsun, Turkey -- [Sipahi, Oguz R.] Ege Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Dulovic, Olga] Clin Ctr Serbia, Clin Infect & Trop Dis, Belgrade, Serbia -- [Sener, Alper] Onsekiz Mart Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Canakkale, Turkey -- [Lakatos, Botond] St Laszlo Hosp, Dept Infect Dis, Budapest, Hungary -- [Andre, Katell] Dax Hosp, Dept Infect Dis, Dax, France -- [Yemisen, Mucahit] Istanbul Univ, Cerrahpasa Med Sch, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Oncu, Serkan] Adnan Menderes Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Aydin, Turkey -- [Nechifor, Mihai] Gr T Popa Univ Med & Pharm, Dept Infect Dis, Iasi, Romania -- [Dragovac, Gorana] Univ Novi Sad, IPH Vojvodina, Fac Med, Dept Prevent & Control Dis, Novi Sad, Serbia -- [Gul, Hanefi C. -- Mert, Gurkan -- Erdem, Hakan] Gulhane Mil Med Acad, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Oncul, Oral] Istanbul Univ, Dept Infect Dis & Clin Microbiol, Istanbul Fac Med, Istanbul, Turkey -- [Kandemir, Bahar] Necmettin Erbakan Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Konya, Turkey -- [Agalar, Canan] Fatih Sultan Mehmet Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey, Inal, Ayse Seza -- 0000-0002-1182-7164, Gencer, Serap -- 0000-0002-3217-6305, GENCER, SERAP -- 0000-0002-3217-6305, Civljak, Rok -- 0000-0001-8766-7438, and Kart Yasar, Kadriye -- 0000-0003-2963-4894
Subjects: Vasculitis, medicine.medical_specialty, Pediatrics, Time Factors, Multivariate analysis, Tuberculosis, Antitubercular Agents, Gastroenterology, Tuberculous meningitis, Clinical, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Meningitis, Retrospective Studies, 030203 arthritis & rheumatology, response, business.industry, Response, meningitis, Retrospective cohort study, Prognosis, medicine.disease, Hydrocephalus, Treatment Outcome, tuberculosis, Neurology, Multicenter study, Tuberculosis, Meningeal, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract: WOS: 000384527500014, PubMed ID: 27625226, Aims: There is no report on the factors affecting the resolution of symptoms related to meningitis during treatment of tuberculous meningitis (TBM). Thus, we examined the factors associated with early therapeutic responses. Materials and Methods: This multicenter study included 507 patients with microbiologically confirmed TBM. However, 94 patients eligible for the analysis were included in this study from 24 centers. Six out of 94 patients died and the statistical analysis was performed with 88 survivors. Early and late responder groups were compared in the statistical analysis. P < 0.05 were considered to show a significant difference. Results: In the multivariate analysis, the presence of vasculitis (P = 0.029, OR = 10.491 [95% CI, 1.27u86.83]) was found to be significantly associated with a delayed fever response whereas hydrocephalus was associated with altered mental status for 9 days duration (P = 0.005, OR = 5.740 [95% CI, 1.68u19.57]). According to linear regression analysis, fever was significantly persisting (7 days) in the presence of vasculitis (17.5 vs. 7, P< 0.001) and hydrocephalus (11 vs. 7, P = 0.029). Hydrocephalus was significantly associated with persisting headache (21 vs. 12, P = 0.025), delayed recovery of consciousness (19.5 vs. 7, P = 0.001), and a delay in complete recovery (21 vs. 14, P = 0.007) in the linear regression analysis. Following institution of treatment, the complaints seemed to disappear in up to 2 weeks among TBM survivors. Conclusions: In the absence of hydrocephalus or vasculitis, one week of anti-tuberculosis treatment seems to be adequate for the resolution of TBM symptoms. Hydrocephalus and vasculitis delay the resolution of TBM symptoms in response to antimycobacterial treatment.
Published: 2016

35. GSBL üreten Klebsiella pneumoniae’nın neden olduğu komplike dev karaciğer apsesi olgusu

Author: Adem Duru, Kadriye Kart Yaşar, Semra Sandikci, Gonul Sengoz, and Filiz Pehlivanoglu
Subjects: medicine.medical_specialty, medicine.diagnostic_test, biology, business.industry, Nausea, Klebsiella pneumoniae, medicine.medical_treatment, Immunosuppression, General Medicine, bacterial infections and mycoses, medicine.disease, biology.organism_classification, Surgery, Biliary tract, Abdominal ultrasonography, medicine, Vomiting, medicine.symptom, business, Abscess, Liver abscess
Abstract: A case report of complicated giant liver abscess caused by ESBL producing Klebsiella pneumoniae Liver abscess most frequently occurs secondary to biliary gland and biliary tract diseases with a clinical picture with fever, nausea and vomiting, and right upper abdominal pain. Diabetes mellitus and immunosuppression are risk factors for abscess formation and other complications. Besides technological innovations, radiological technics and invasive procedures have been developed for diagnosis and this has led to decrease in the mortality and morbidity of liver abscess. Abdominal ultrasonography is a frequently used method but, computed tomography is the gold standard for diagnosis. In this study, a 67-year-old diabetic male patient who developed complicated liver abscess after laparoscopic cholesystectomy caused by
Published: 2012

36. Coexıstence of Advanced Age and Female Gender in Dıabetıcs Wıth Extrapulmonary Tuberculosıs: Four Culture-Proven Cases

Author: Gonul Sengoz, Ahmet Sengoz, Kadriye Kart Yaşar, and Filiz Pehlivanoglu
Subjects: Spondylodiscitis, medicine.medical_specialty, Tuberculosis, Antitubercular Agents, Diabetes Complications, Gender Studies, Mycobacterium tuberculosis, Lesion, Internal medicine, Diabetes mellitus, medicine, Humans, Synovial fluid, Abscess, Aged, biology, business.industry, Age Factors, General Medicine, Middle Aged, medicine.disease, biology.organism_classification, Tuberculosis, Meningeal, Immunology, Female, Tuberculosis, Spinal, medicine.symptom, business, Meningitis
Abstract: Background The relationship between diabetes mellitus (DM) and tuberculosis (TB) has long been known, but the extent of the relationship has only recently been demonstrated. It has been suggested that the presence of DM could triple the risk of TB. Objective Within the clinical picture of culture-proven TB, we examined the coexistence of TB, DM, and advanced age in 4 diabetic female elderly patients. Case summary Four cases of women with meningitis, bone TB, spondylodiscitis, and meningitis and spondylodiscitis are presented. All patients were diabetic and aged 50 to 79 years. Mycobacterium tuberculosis was isolated from the abscess from lesion areas, cerebrospinal fluid, and synovial fluid samples. Conclusion Presence of DM is known to trigger reactivation of TB. These 4 diabetic female patients are noteworthy because they show that coexistence of DM and TB might lead to progressive forms of extrapulmonary TB in advanced age.
Published: 2011

37. The Effect of Culture Technique on Culture Positivity in Peritoneal Dialysis Patients with Peritonitis

Author: Zeki Aydin, Rumeyza Kazancioglu, Meltem Gursu, Filiz Pehlivanoglu, Savas Ozturk, Emel Tatli, Sami Uzun, Serhat Karadag, Gonul Sengoz, and KAZANCIOĞLU, Rümeyza
Subjects: Microbiology (medical), medicine.medical_specialty, Infectious Diseases, GÜRSU M., Aydın Z., OZTURK S., PEHLIVANOGLU F., ŞENGÖZ G., UZUN S., KARADAG S., tatlı e., KAZANCIOĞLU R., -The effect of culture technique on culture positivity in peritoneal dialysis patients with peritonitis-, KLIMIK JOURNAL, cilt.24, ss.94-97, 2011, business.industry, Internal medicine, medicine.medical_treatment, medicine, Peritonitis, medicine.disease, business, Gastroenterology, Peritoneal dialysis
Published: 2011

38. Microorganisms Isolated from Cerebrospinal Fluid and their Antibiotic Resistance

Author: Kadriye Kart Yaşar, Gonul Sengoz, and Filiz Pehlivanoglu
Subjects: Cerebrospinal fluid, Antibiotic resistance, business.industry, Microorganism, General Engineering, Medicine, business, Microbiology
Published: 2011

39. Effectiveness of Fosfomycin as an Alternative Therapy Choice to ESBL Producing Escherichia coli Strains Isolated from Complicated Urinary Tract Infections

Author: Kadriye Kart Yaşar, Filiz Pehlivanoglu, and Gonul Sengoz
Subjects: Alternative therapy, business.industry, Urinary system, General Engineering, Esbl production, medicine, Fosfomycin, medicine.disease_cause, business, Escherichia coli, Microbiology, medicine.drug
Published: 2011

40. Recurrent paradoxical reaction in a patient with tuberculous meningitis and intracranial tuberculomas

Author: Kadriye Kart Yaşar, Filiz Pehlivanoglu, Gonul Sengoz, Bedriye Nur Ayrancioglu, and Emine Rahsan Ince
Subjects: Pediatrics, medicine.medical_specialty, business.industry, medicine, Paradoxical reaction, medicine.disease, business, Tuberculous meningitis
Published: 2011

41. Peritonitis due to Candida Guilliermondii in a Patient on Continuous Ambulatory Peritoneal Dialysis

Author: Ozturk Savas, Zeki Aydin, Rumeyza Kazancioglu, Emel Tatli, Egemen Cebeci, Serhat Karadag, Sami Uzun, Filiz Pehlivanoglu, Meltem Gursu, and KAZANCIOĞLU, Rümeyza
Subjects: medicine.medical_specialty, lcsh:R5-920, business.industry, Continuous ambulatory peritoneal dialysis, lcsh:R, candida guilliermondii, Peritonitis, lcsh:Medicine, General Medicine, medicine.disease, Gastroenterology, Internal medicine, ambulatory peritoneal dialysis, Medicine, Candida guilliermondii, business, lcsh:Medicine (General), Peritoneal Dialysis
Abstract: Peritonitis still maintains its importance today as the most significant complication affecting mortality and morbidity in peritoneal dialysis (PD) patients. Although peritonitis is bacterial in 80% of cases, increasing rate of fungal peritonitis has been reported by many studies in recent years. While Candida species (mainly C. parapsilosis, C. albicans and C. tropicalis) are responsible for 70% of cases, other species (Trichosporon, Penicillium, Aspergillus and Acremonium) are very rarely seen. C. guilliermondii has been reported as the cause of peritonitis in PD patients in a few cases. Herein, we present a PD patient with peritonitis due to C. guilliermondii. We aimed to emphasize that non-albicans Candida species should be remembered in PD patients with peritonitis.
Published: 2015

42. Predictors for limb loss among patient with diabetic foot infections: an observational retrospective multicentric study in Turkey

Author: Gonul Sengoz, Nazan Tuna, U. Tozalgan, Funda Şimşek, Oguz Karabay, Kadriye Kart Yaşar, Meral Sonmezoglu, Asli Vatan, Fahri Yilmaz, B. Erturk, M. Ozyazar, Onder Ergonul, Fatma Sargin, Serdar Özer, Yasar Kucukardali, Atahan Cagatay, Nurgul Ceran, Hakan Ay, Ayse Batirel, Yasemin Akkoyunlu, Mucahit Yemisen, Filiz Pehlivanoglu, Derya Ozturk Engin, Ayten Kadanali, Lutfiye Mulazimoglu, Haluk Eraksoy, Oral Oncul, Taner Yildirmak, Nuray Uzun, Nail Ozgunes, Oznur Ak, Gül Karagöz, Nese Saltoglu, Turan Aslan, AKKOYUNLU, YASEMİN, Saltoglu, N., Yemisen, M., Ergonul, O., Kadanali, A., Karagoz, G., Batirel, A., Ak, O., Eraksoy, H., Cagatay, A., Vatan, A., Sengoz, G., Pehlivanoglu, F., Aslan, T., Akkoyunlu, Y., Engin, D., Ceran, N., Erturk, B., Mulazimoglu, L., Oncul, O., Ay, H., Sargin, F., Ozgunes, N., Simsek, F., Yildirmak, T., Tuna, N., Karabay, O., Yasar, K., Uzun, N., Kucukardali, Y., Sonmezoglu, M., Yilmaz, F., Tozalgan, U., Ozer, S., and Ozyazar, M.
Subjects: Male, Microbiology (medical), medicine.medical_specialty, Turkey, medicine.medical_treatment, Antimicrobial resistance, Amputation, Surgical, Risk Factors, Diabetes mellitus, Internal medicine, OSTEOMYELITIS, MANAGEMENT, medicine, Humans, EPIDEMIOLOGY, infections, LOWER-EXTREMITY AMPUTATION, Aged, Retrospective Studies, an observational retrospective multicentric study in Turkey-, CLINICAL MICROBIOLOGY AND INFECTION, cilt.21, ss.659-664, 2015 [Saltoglu N., Yemisen M., Ergonul O., KADANALI A., KARAGOZ G., BATIREL A., AK O., Eraksoy H., Cagatay A., Vatan A., et al., -Predictors for limb loss among patient with diabetic foot infections], medicine.diagnostic_test, Vascular disease, business.industry, General Medicine, Middle Aged, medicine.disease, limb loss, Diabetic foot, Gram-negative, Surgery, Infectious Diseases, Amputation, Erythrocyte sedimentation rate, Cellulitis, Etiology, Female, business, diabetic foot, Retinopathy
Abstract: We aimed to investigate the predictors for limb loss among patients with diabetes who have complicated skin/soft-tissue infections. In this observational study, consecutive patients with diabetic foot infection (DFI) from 17 centres in Turkey, between May 2011 and May 2013 were included. The Turkish DFI Working Group performed the study. Predictors of limb loss were investigated by multivariate analysis. In total, 455 patients with DFI were included. Median age was 61 years, 68% were male, 65% of the patients were hospitalized, 52% of the patients had used antibiotics within the last month, and 121(27%) had osteomyelitis. Of the 208 microorganisms isolated, 92 (44.2%) were Gram-positive cocci and 114 (54.8%) were Gram-negative rods (GNR). The most common GNR was Pseudomonas; the second was Escherichia coli, with extended spectrum beta-lactamase positivity of 33%. Methicillin-resistant Staphylococcus species were found in 14% (29/208). Amputations were performed in 126/455 (28%) patients, 44/126 (34%) of these were major amputations. In multivariate analysis, significant predictors for limb loss were, male gender (OR 1.75, 95% Cl 1.04-2.96, p 0.034), duration of diabetes >20 years (OR 1.9, 95% Cl 1.18-3.11, p 0.008), infected ulcer versus cellulitis (OR 1.9, 95% Cl 1.11-3.18, p 0.019), history of peripheral vascular disease (OR 2, 95% Cl 1.26-3.27, p 0.004), retinopathy (OR 2.25, 95% Cl 1.19-4.25, p 0.012), erythrocyte sedimentation rate >70 mm/hr (OR 1.6, 95% Cl 1.01-2.68, p 0.05), and infection with GNR (OR 1.8, 95% Cl 1.08-3.02, p 0.02). Multivariate analysis revealed that, besides the known risk factors such as male gender, duration of diabetes >20 years, infected ulcers, history of peripheral vascular disease and retinopathy, detection of GNR was a significant predictor of limb loss. Clinical Microbiology and Infection (C) 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Published: 2015

43. Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis

Author: Pierre Tattevin, Salih Atakan Nemli, Hasan Karsen, Mustafa Sunbul, Rosa Fontana Del Vecchio, Akram Al-Mahdawi, Mahtab Chehri, Süheyla Kömür, Sylviane Defres, Bruno Baršić, Signe Maj Sørensen, Seniha Senbayrak, Ghaydaa A. Shehata, Nevin Ince, Abdullah Umut Pekok, Selçuk Kaya, Yasemin Akkoyunlu, Gulden Yilmaz, Jean-Paul Stahl, Lykke Larsen, Lenka Baštáková, Gonul Sengoz, Jesper Damsgaard Gunst, Guillaume Béraud, Emine Parlak, Hakan Erdem, Sukran Kose, Oğuz Reşat Sipahi, Hava Yilmaz, Filiz Pehlivanoglu, Xavier Argemi, Asuman Inan, Hulya Tireli, Haluk Vahaboglu, Elif Sahin-Horasan, Souha S. Kanj, Gamze Kilicoglu, Fatime Korkmaz, Anne Lisbeth Bohr, Oguz Karabay, Mehmet Ulug, Gulistan Halac, Derya Ozturk-Engin, Seher Ayten Coskuner, Mario Poljak, Mauro Maresca, Sibel Bolukcu, Ahmad Sharif-Yakan, Yasemin Cag, Isik Somuncu Johansen, Matjaž Jereb, Ege Üniversitesi, AKKOYUNLU, YASEMİN, Erdem, H, Cag, Y, Ozturk-Engin, D, Defres, S, Kaya, S, Larsen, L, Poljak, M, Barsic, B, Argemi, X, Sorensen, SM, Bohr, AL, Tattevin, P, Gunst, JD, Bastakova, L, Jereb, M, Johansen, IS, Karabay, O, Pekok, AU, Sipahi, OR, Chehri, M, Beraud, G, Shehata, G, Del Vecchio, RF, Maresca, M, Karsen, H, Sengoz, G, Sunbul, M, Yilmaz, G, Yilmaz, H, Sharif-Yakan, A, Kanj, SS, Parlak, E, Pehlivanoglu, F, Korkmaz, F, Komur, S, Kose, S, Ulug, M, Bolukcu, S, Coskuner, SA, Ince, N, Akkoyunlu, Y, Halac, G, Sahin-Horasan, E, Tireli, H, Kilicoglu, G, Al-Mandawi, A, Nemli, SA, Inan, A, Senbayrak, S, Stahl, JP, Vahaboglu, H, Sakarya Üniversitesi/İlahiyat Fakültesi/Temel İslam Bilimleri Bölümü, Kaya, Süleyman, Karabay, Oğuz, Çukurova Üniversitesi, and OMÜ
Subjects: Adult, Male, medicine.medical_specialty, Referral, Antiviral Agents, Internal medicine, medicine, ERDEM H., CAG Y., OZTURK-ENGIN D., Defres S., KAYA S., LARSEN L., POLJAK M., BARSIC B., ARGEMI X., SORENSEN S. M. , et al., -Results of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitis-, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, cilt.59, ss.3084-3089, 2015, Confidence Intervals, Humans, Pharmacology (medical), Pharmacology & Pharmacy, Antiviral treatment, Retrospective Studies, Pharmacology, business.industry, Herpetic meningoencephalitis, Glasgow Coma Scale, Retrospective cohort study, Odds ratio, Middle Aged, medicine.disease, Confidence interval, 3. Good health, Surgery, Infectious Diseases, Treatment Outcome, Female, Encephalitis, Herpes Simplex, business, Encephalitis
Abstract: WOS: 000358623200015, PubMed ID: 25779579, Data in the literature regarding the factors that predict unfavorable outcomes in adult herpetic meningoencephalitis (HME) cases are scarce. We conducted a multicenter study in order to provide insights into the predictors of HME outcomes, with special emphasis on the use and timing of antiviral treatment. Samples from 501 patients with molecular confirmation from cerebrospinal fluid were included from 35 referral centers in 10 countries. Four hundred thirty-eight patients were found to be eligible for the analysis. Overall, 232 (52.9%) patients experienced unfavorable outcomes, 44 died, and 188 survived, with sequelae. Age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02 to 1.05), Glasgow Coma Scale score (OR, 0.84; 95% CI, 0.77 to 0.93), and symptomatic periods of 2 to 7 days (OR, 1.80; 95% CI, 1.16 to 2.79) and >7 days (OR, 3.75; 95% CI, 1.72 to 8.15) until the commencement of treatment predicted unfavorable outcomes. The outcome in HME patients is related to a combination of therapeutic and host factors. This study suggests that rapid diagnosis and early administration of antiviral treatment in HME patients are keys to a favorable outcome.
Published: 2015

44. Hamsi scoring in the prediction of unfavorable outcomes from tuberculous meningitis: results of Haydarpasa-II study

Author: Sukran Kose, Branislava Savic, Selma Alabay, Emine Parlak, Recep Tekin, Ayhan Akbulut, Gulden Yilmaz, Haluk Vahaboglu, Nataša Popović, Özcan Deveci, Akram Al-Mahdawi, Hanefi Cem Gul, Canan Agalar, Serkan Oncu, Soline Simeon, Seniha Senbayrak, Hulya Tireli, Mehmet Bitirgen, Catalina Luca, Bahar Kandemir, Sylviane Defres, Oguz Karabay, Oğuz Reşat Sipahi, Ghaydaa A. Shehata, Alper Şener, Aysegul Ulu-Kilic, Saim Dayan, Nazif Elaldi, Mihai Nechifor, Ayşe Seza Inal, Mucahit Yemisen, Filiz Pehlivanoglu, Asuman Inan, B. Lakatos, Mustafa Namiduru, Nurgul Ceran, Muge Ozguler, Alexandru Crisan, Ahmet Karakaş, Jean-Paul Stahl, Gamze Kilicoglu, Mustafa Sunbul, Elif Sahin-Horasan, Hakan Erdem, Gorana Dragovac, Valerija Kirova, Ahmad Khalifa, Emel Yilmaz, Bruno Cacopardo, Gonul Sengoz, Hacer Deniz Ozkaya, Ebru Kurşun, Serda Gulsun, Rok Čivljak, Bojana Beović, Melanie Catroux, Oral Oncul, Isabelle Masse-Chabredier, Isik Somuncu Johansen, Katell Andre, Kadriye Kart Yaşar, Derya Ozturk-Engin, Uner Kayabas, Stéphane Chadapaud, Mehmet Parlak, Arjan Harxhi, Yves Hansmann, Ondokuz Mayıs Üniversitesi, Çukurova Üniversitesi, [Erdem, Hakan -- Oncul, Oral] GATA Haydarpasa Training Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Erdem, Hakan] GATA Haydarpasa AH, Enfeksiyon Hastaliklari Servisi, Istanbul, Turkey -- [Ozturk-Engin, Derya -- Inan, Asuman -- Ceran, Nurgul -- Senbayrak, Seniha] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Tireli, Hulya] Haydarpasa Numune Training & Res Hosp, Dept Neurol, Istanbul, Turkey -- [Kilicoglu, Gamze] Haydarpasa Numune Training & Res Hosp, Dept Radiol, Istanbul, Turkey -- [Defres, Sylviane] Univ Liverpool, Inst Infect & Global Hlth, Liverpool L69 3BX, Merseyside, England -- [Defres, Sylviane] Royal Liverpool & Broadgreen Univ Hosp NHS Trust, Trop Infect Dis Unit, Liverpool, Merseyside, England -- [Gulsun, Serda] Diyarbakir Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Sengoz, Gonul -- Pehlivanoglu, Filiz] Haseki Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Crisan, Alexandru] Victor Babes Univ Med & Pharm, Dept Infect Dis, Timisoara, Romania -- [Johansen, Isik Somuncu] Odense Univ Hosp, Dept Infect Dis Q, DK-5000 Odense, Denmark -- [Nechifor, Mihai] Gr T Popa Univ Med & Pharm, Dept Pharmacol, Iasi, Romania -- [Al-Mahdawi, Akram] Baghdad Teaching Hosp, Dept Neurol, Baghdad, Iraq -- [Civljak, Rok] Univ Zagreb, Sch Med, Dr Fran Mihaljev Univ Hosp Infect Dis, Dept Infect Dis, Zagreb 41000, Croatia -- [Ozguler, Muge -- Akbulut, Ayhan] Firat Univ, Sch Med, Dept Infect Dis & Clin Microbiol, TR-23169 Elazig, Turkey -- [Savic, Branislava] Univ Belgrade, Fac Med, Inst Microbiol & Immunol, Natl Reference Lab TB, Belgrade, Serbia -- [Cacopardo, Bruno] Univ Catania, Dept Clin & Mol Biomed, Infect Dis Sect, Catania, Italy -- [Inal, Ayse Seza] Cukurova Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Adana, Turkey -- [Namiduru, Mustafa] Gaziantep Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Gaziantep, Turkey -- [Dayan, Saim -- Tekin, Recep -- Deveci, Ozcan] Dicle Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Kayabas, Uner] Inonu Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Malatya, Turkey -- [Parlak, Emine -- Parlak, Mehmet] Ataturk Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Erzurum, Turkey -- [Khalifa, Ahmad] Damascus Hosp, Dept Neurol, Damascus, Syria -- [Kursun, Ebru] Baskent Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Adana, Turkey -- [Sipahi, Oguz Resat] Ege Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Yemisen, Mucahit] Istanbul Univ, Cerrahpasa Med Sch, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Bitirgen, Mehmet -- Kandemir, Bahar] Necmettin Erbakan Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Konya, Turkey -- [Popovic, Natasa] Clin Ctr Serbia, Clin Infect & Trop Dis, Belgrade, Serbia -- [Luca, Catalina] Gr T Popa Univ Med & Pharm, Dept Infect Dis, Iasi, Romania -- [Stahl, Jean Paul] Univ Grenoble 1, Dept Infect Dis, Grenoble, France -- [Stahl, Jean Paul] Univ Hosp Grenoble, Grenoble, France -- [Simeon, Soline] Univ Hosp Pontchaillou, Dept Infect & Trop Dis, Rennes, France -- [Ulu-Kilic, Aysegul -- Alabay, Selma] Erciyes Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Kayseri, Turkey -- [Yasar, Kadriye] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Yilmaz, Gulden] Ankara Univ, Sch Med, Dept Infect Dis & Clin Microbiol, TR-06100 Ankara, Turkey -- [Yilmaz, Emel] Uludag Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Bursa, Turkey -- [Beovic, Bojana] Univ Med Ctr, Dept Infect Dis, Ljubljana, Slovenia -- [Catroux, Melanie] Univ Poitiers Hosp, Dept Infect Dis, Poitiers, France -- [Lakatos, Botond] St Laszlo Hosp, Dept Infect Dis, Budapest, Hungary -- [Sunbul, Mustafa] Ondokuz Mayis Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Samsun, Turkey -- [Sahin-Horasan, Elif] Mersin Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Kose, Sukran] Tepecik Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Shehata, Ghaydaa] Assiut Univ Hosp, Dept Neurol & Psychiat, Assiut, Egypt -- [Andre, Katell] Dax Hosp, Dept Infect Dis, Dax, France -- [Dragovac, Gorana] Univ Novi Sad, Fac Med, IPH Vojvodina, Dept Prevent & Control Dis, Novi Sad 21000, Serbia -- [Gul, Hanefi Cem -- Karakas, Ahmet] Gulhane Mil Med Acad, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Chadapaud, Stephane] Marie Jose Treffot Hosp, Dept Infect Dis, Hyeres, France -- [Hansmann, Yves] Univ Hosp, Dept Infect Dis, Strasbourg, France -- [Harxhi, Arjan] Univ Hosp Ctr Tirana, Infect Dis Serv, Tirana, Albania -- [Kirova, Valerija] Univ Clin Infect Dis & Febrile Condit, Skopje, Macedonia -- [Masse-Chabredier, Isabelle] Aurillac Hosp, Dept Infect Dis, Aurillac, France -- [Oncu, Serkan] Adnan Menderes Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Aydin, Turkey -- [Sener, Alper] Onsekiz Mart Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Canakkale, Turkey -- [Elaldi, Nazif] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Ozkaya, Hacer Deniz] Karsiyaka State Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Karabay, Oguz] Sakarya Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sakarya, Turkey -- [Agalar, Canan] Fatih Sultan Mehmet Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Vahaboglu, Haluk] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey, Inal, Ayse Seza -- 0000-0002-1182-7164, Ghaydaa, Shehata -- 0000-0002-3631-893X, Civljak, Rok -- 0000-0001-8766-7438, Karabay, Oguz -- 0000-0003-0502-432X, VAHABOGLU, Haluk -- 0000-0001-8217-1767, Karakas, Ahmet -- 0000-0002-0553-8454, Elaldi, Nazif -- 0000-0002-9515-770X, johansen, isik somuncu -- 0000-0002-2189-9823, Stahl, Jean Paul -- 0000-0002-0086-3557, Kart Yasar, Kadriye -- 0000-0003-2963-4894, Erdem, H, Ozturk-Engin, D, Tireli, H, Kilicoglu, G, Defres, S, Gulsun, S, Sengoz, G, Crisan, A, Johansen, IS, Inan, A, Nechifor, M, Al-Mahdawi, A, Civljak, R, Ozguler, M, Savic, B, Ceran, N, Cacopardo, B, Inal, AS, Namiduru, M, Dayan, S, Kayabas, U, Parlak, E, Khalifa, A, Kursun, E, Sipahi, OR, Yemisen, M, Akbulut, A, Bitirgen, M, Popovic, N, Kandemir, B, Luca, C, Parlak, M, Stahl, JP, Pehlivanoglu, F, Simeon, S, Ulu-Kilic, A, Yasar, K, Yilmaz, G, Yilmaz, E, Beovic, B, Catroux, M, Lakatos, B, Sunbul, M, Oncul, O, Alabay, S, Sahin-Horasan, E, Kose, S, Shehata, G, Andre, K, Dragovac, G, Gul, HC, Karakas, A, Chadapaud, S, Hansmann, Y, Harxhi, A, Kirova, V, Masse-Chabredier, I, Oncu, S, Sener, A, Tekin, R, Elaldi, N, Deveci, O, Ozkaya, HD, Karabay, O, Senbayrak, S, Agalar, C, Vahaboglu, H, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, and Parlak, Erkan
Subjects: Adult, Male, Pediatrics, medicine.medical_specialty, International Cooperation, Logistic regression, Sensitivity and Specificity, Severity of Illness Index, Tuberculous meningitis, Cohort Studies, Sequelae, Predictive Value of Tests, Surveys and Questionnaires, Outcome Assessment, Health Care, Severity of illness, medicine, Tuberculosis, Meningitis, Death, Outcome, Sequela, Humans, Tuberculosis, Meningitis, Death, Outcome, Sequelae, Clinical Trials as Topic, business.industry, Middle Aged, medicine.disease, Hydrocephalus, Logistic Models, Treatment Outcome, Neurology, Tuberculosis, Meningeal, Predictive value of tests, Female, Neurosciences & Neurology, Neurology (clinical), Nervous System Diseases, business, Cohort study
Abstract: WOS: 000353295400011, PubMed ID: 25634680, Predicting unfavorable outcome is of paramount importance in clinical decision making. Accordingly, we designed this multinational study, which provided the largest case series of tuberculous meningitis (TBM). 43 centers from 14 countries (Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia, Syria, Turkey) submitted data of microbiologically confirmed TBM patients hospitalized between 2000 and 2012. Unfavorable outcome was defined as survival with significant sequela or death. In developing our index, binary logistic regression models were constructed via 200 replicates of database by bootstrap resampling methodology. The final model was built according to the selection frequencies of variables. The severity scale included variables with arbitrary scores proportional to predictive powers of terms in the final model. The final model was internally validated by bootstrap resampling. A total of 507 patients' data were submitted among which 165 had unfavorable outcome. Eighty-six patients died while 119 had different neurological sequelae in 79 (16 %) patients. The full model included 13 variables. Age, nausea, vomiting, altered consciousness, hydrocephalus, vasculitis, immunosuppression, diabetes mellitus and neurological deficit remained in the final model. Scores 1-3 were assigned to the variables in the severity scale, which included scores of 1-6. The distribution of mortality for the scores 1-6 was 3.4, 8.2, 20.6, 31, 30 and 40.1 %, respectively. Altered consciousness, diabetes mellitus, immunosuppression, neurological deficits, hydrocephalus, and vasculitis predicted the unfavorable outcome in the scoring and the cumulative score provided a linear estimation of prognosis.
Published: 2015

45. A Rare Case of Peritonitis: Streptococcus Salivarius

Author: Meltem Gursu, Filiz Pehlivanoglu, Rumeyza Kazancioglu, Abdullah Sumnu, Nilay Sengul Samanci, Serhat Karadag, Egemen Cebeci, Savas Ozturk, and KAZANCIOĞLU, Rümeyza
Subjects: Nephrology, Streptococcus salivarius-, BANTAO Journal, cilt.13, ss.95-96, 2015 [Cebeci E., Samanci N. S. , GÜRSU M., Ozturk S., Pehlivanoglu F., Sumnu A., Karadag S., KAZANCIOĞLU R., -A rare case of peritonitis], Transplantation, medicine.medical_specialty, biology, business.industry, 030232 urology & nephrology, Peritonitis, biology.organism_classification, medicine.disease, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Streptococcus salivarius, Internal medicine, Rare case, medicine, 030212 general & internal medicine, business
Abstract: Streptococcus salivarius is a Gram-positive bacteria that may cause infections like endocarditis and meningitis. However, it has not been reported as a causative agent of peritonitis in peritoneal dialysis patients. In this paper we present a rare case of peritonitis with Streptococcus salivarius admitted to our Clinic with abdominal pain, who had been on peritoneal dialysis treatment for 19 months. Streptococus salivarius was cultured from the effluent, sensitive to ampicillin and penicillin G. Patient was discharged completely cured. Peritonitis is the most important clinical issue that occurs in patients treated with peritoneal dialysis, and every effort should be invested to determine the causative agent while even rare bacteria as Streptococcus salivarius may be found.
Published: 2015

46. Tuberculous meningoencephalitis with severe neurological sequel in an immigrant child

Author: Filiz Pehlivanoglu, Gonul Sengoz, E. Rahşan Ince, Kadriye Kart Yaşar, and Semra Sandikci
Subjects: Pediatrics, medicine.medical_specialty, Tuberculosis, media_common.quotation_subject, Immigration, Case Report, Disease, immigrant, urologic and male genital diseases, 030218 nuclear medicine & medical imaging, lcsh:RC321-571, 03 medical and health sciences, 0302 clinical medicine, pcr, tuberculous meningoencephalitis, medicine, Family history, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, media_common, Tuberculous meningoencephalitis, business.industry, General Neuroscience, neurological sequel, High mortality, Delayed treatment, medicine.disease, tuberculosis, Immunology, Neurology (clinical), Severe course, business, 030217 neurology & neurosurgery
Abstract: Central nervous system tuberculosis (TB) is the most devastating manifestation of TB. It is a challenge for clinicians because of the diffi culty in making an early diagnosis and the severe consequences of delayed treatment. The aim of this report is to point out the relation between migration and TB based on a 14-year-old child with tuberculous meningoencephalitis (TBM) of an immigrant family. Migration, crowded living conditions and positive family history contribute to the severe course of TB as TBM and miliary TB forms. TB control may prevent these severe manifestations of the disease among immigrants. Prompt diagnosis with helpful early diagnostic tools like polymerase chain reaction in TBM is crucial due to the high mortality and morbidity.
Published: 2011

47. List of Contributors

Author: Jaffar A. Al-Tawfiq, Sevtap Arikan-Akdagli, Tatjana Avšič Županc, Alpay Azap, Daniel G. Bausch, M. Bulent Ertugrul, Remi N. Charrel, Charles Chiu, Jakob P. Cramer, Stefano Di Bella, Laurent Dortet, Cecilia Melina Drapeau, Hideki Ebihara, Önder Ergönül, Koray Ergunay, Joseph Fair, Heinz Feldmann, Pierre Formenty, Donald S. Grant, Gilda Grard, Jan Heyckendorf, Gene Khai Lin Huang, Paul Johnson, Yasuyuki Kato, Humarr Khan, Miša Korva, Christoph Lange, Eric Leroy, Larry Lutwick, Julia Martensen, Keita Matsuno, Momoko Mawatari, Ziad A. Memish, Yasutaka Mizuno, Itaru Nakamura, Patrice Nordmann, Janusz T. Paweska, Filiz Pehlivanoglu, Nicola Petrosillo, Miroslav Petrovec, Laurent Poirel, Jana Preis, Giovanni Rezza, Pierre E. Rollin, John Schieffelin, Gerold Stanek, Franc Strle, Daša Stupica, and Tina Uršič
Published: 2014

48. Mortality Indicators In Pneumococcal Meningitis: Therapeutic Implications

Author: Mustafa Gökhan Gözel, Füsun Zeynep Akçam, Nefise Oztoprak, Asim Ulcay, Derya Ozturk-Engin, Gonul Sengoz, Gunay Tuncer-Ertem, Saygin Nayman-Alpat, Yasemin Ersoy, Gülden Ersöz, Nazif Elaldi, Ayse Sagmak-Tartar, Oğuz Reşat Sipahi, Selçuk Kaya, Recep Tekin, Emsal Aydin, Hava Yilmaz, Nail Ozgunes, Alper Şener, Sibel Gundes, Ayşegül Yeşilkaya, Tumer Guven, Hakan Erdem, Birsen Cetin, Derya Seyman, Vedat Turhan, Oznur Ak, Kadriye Kart Yaşar, Ahmet Karakaş, Oral Oncul, Ahmet Çağkan İnkaya, Gonul Cicek-Senturk, Yasemin Akkoyunlu, Oguz Karabay, Hakan Leblebicioglu, Ilker Inanc Balkan, Aysegul Ulu-Kilic, Mustafa Hatipoglu, Aysun Yalci, Husrev Diktas, Ayşe Ertürk, Filiz Pehlivanoglu, Selma Alabay, Asuman Inan, Umit Savasci, Alper Gunduz, Ayhan Akbulut, Fatma Sirmatel, Haluk Vahaboglu, Esra Kazak, Saim Dayan, Sukran Kose, Selma Tosun, Abdullah Umut Pekok, İç Hastalıkları, BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Sırmatel, Fatma, [Erdem, Hakan -- Hatipoglu, Mustafa -- Oncul, Oral -- Turhan, Vedat -- Ulcay, Asim] GATA Haydarpasa Training Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Elaldi, Nazif -- Gozel, Mustafa G.] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Oztoprak, Nefise -- Seyman, Derya] Antalya Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Antalya, Turkey -- [Sengoz, Gonul -- Pehlivanoglu, Filiz] Haseki Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Ak, Oznur] Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Kaya, Selcuk] Karadeniz Tech Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Trabzon, Turkey -- [Inan, Asuman -- Ozturk-Engin, Derya] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Nayman-Alpat, Saygin] Osmangazi Univ Sch Med, Dept Infect Dis & Clin Microbiol, Eskisehir, Turkey -- [Ulu-Kilic, Aysegul -- Alabay, Selma] Erciyes Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Kayseri, Turkey -- [Pekok, Abdullah Umut] Private Erzurum Sifa Hosp, Dept Infect Dis & Clin Microbiol, Erzurum, Turkey -- [Gunduz, Alper] Sisli Etfal Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Yasar, Kadriye] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Yilmaz, Hava -- Leblebicioglu, Hakan] Ondokuz Mayis Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Samsun, Turkey -- [Cicek-Senturk, Gonul] Diskapi Yildirim Beyazit Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Akcam, Fusun Z.] Suleyman Demirel Univ, Sch Med, Dept Infect Dis & Clin Microbiol, TR-32200 Isparta, Turkey -- [Inkaya, Ahmet C.] Hacettepe Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Kazak, Esra] Uludag Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Bursa, Turkey -- [Sagmak-Tartar, Ayse -- Akbulut, Ayhan] Firat Univ, Sch Med, Dept Infect Dis & Clin Microbiol, TR-23169 Elazig, Turkey -- [Tekin, Recep -- Dayan, Saim] Dicle Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Ersoy, Yasemin] Inonu Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Malatya, Turkey -- [Sipahi, Oguz Resat] Ege Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Guven, Tumer] Ankara Ataturk Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Tuncer-Ertem, Gunay] Ankara Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Balkan, Ilker I.] Istanbul Univ, Cerrahpasa Med Sch, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Cetin, Birsen] Koc Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Ersoz, Gulden] Mersin Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Mersin, Turkey -- [Karakas, Ahmet] Gulhane Mil Med Acad, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Ozgunes, Nail -- Vahaboglu, Haluk] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Sener, Alper] Onsekiz Mart Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Canakkale, Turkey -- [Yesilkaya, Aysegul] Baskent Univ, Sch Med, Dept Infect Dis & Clin Microbiol, TR-06490 Ankara, Turkey -- [Erturk, Ayse] Recep Tayyip Erdogan Univ, Sch Med, Dept Dept Infect Dis & Clin Microbiol, Rize, Turkey -- [Gundes, Sibel] Kocaeli Univ, Sch Med, Dept Dept Infect Dis & Clin Microbiol, Izmit, Turkey -- [Karabay, Oguz] Sakarya Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sakarya, Turkey -- [Sirmatel, Fatma] Abant Izzet Baysal Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Bolu, Turkey -- [Tosun, Selma] Izmir Bozyaka Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Yalci, Aysun] Ankara Univ, Sch Med, Dept Infect Dis & Clin Microbiol, TR-06100 Ankara, Turkey -- [Akkoyunlu, Yasemin] Bezmi Alem Vakif Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Aydin, Emsal] Kafkas Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Kars, Turkey -- [Diktas, Husrev] Mil Hosp, Dept Infect Dis & Clin Microbiol, Tatvan, Turkey -- [Kose, Sukran -- Savasci, Umit] Tepecik Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- Dept Infect Dis & Clin Microbiol, Sarikamis Mil Hosp, Kars, Turkey, Yesilkaya, Aysegul -- 0000-0003-0225-6416, Leblebicioglu, Hakan -- 0000-0002-6033-8543, VAHABOGLU, Haluk -- 0000-0001-8217-1767, Elaldi, Nazif -- 0000-0002-9515-770X, Gozel, Mustafa Gokhan -- 0000-0001-5187-7388, Kart Yasar, Kadriye -- 0000-0003-2963-4894, Karakas, Ahmet -- 0000-0002-0553-8454, Karabay, Oguz -- 0000-0003-0502-432X, Ersoy, Yasemin -- 0000-0001-5730-6682, hatipoglu, mustafa -- 0000-0001-9910-1650, Gunduz, Alper -- 0000-0001-9154-844X, HATİBOĞLU, MUSTAFA AZİZ, Ege Üniversitesi, and OMÜ
Subjects: Microbiology (medical), Streptococcus Pneumoniae, Adult, Male, medicine.medical_specialty, Adolescent, Turkey, Penicillin Resistance, Resistance, Microbial Sensitivity Tests, Penicillins, medicine.disease_cause, Cohort Studies, Young Adult, Vancomycin, Internal medicine, Streptococcus pneumoniae, medicine, Humans, Meningitis, Mortality, Intensive care medicine, pneumococcal meningitis, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Meningitis, Pneumococcal, Ceftriaxone, General Medicine, Odds ratio, Middle Aged, medicine.disease, Penicillin, Confidence interval, Anti-Bacterial Agents, Cephalosporins, Treatment Outcome, Infectious Diseases, Drug Therapy, Combination, Female, business, Cohort study, medicine.drug
Abstract: WOS: 000329981700003, PubMed ID: 24211227, Background: The aim of this study was to delineate mortality indicators in pneumococcal meningitis with special emphasis on therapeutic implications. Methods: This retrospective, multicenter cohort study involved a 15-year period (1998-2012). Culture-positive cases (n = 306) were included solely from 38 centers. Results: Fifty-eight patients received ceftriaxone plus vancomycin empirically. The rest were given a third-generation cephalosporin alone. Overall, 246 (79.1%) isolates were found to be penicillin-susceptible, 38 (12.2%) strains were penicillin-resistant, and 22 (7.1%) were oxacillin-resistant (without further minimum inhibitory concentration testing for penicillin). Being a critical case (odds ratio (OR) 7.089, 95% confidence interval (CI) 3.230-15.557) and age over 50 years (OR 3.908, 95% CI 1.820-8.390) were independent predictors of mortality, while infection with a penicillin-susceptible isolate (OR 0.441, 95% CI 0.195-0.996) was found to be protective. Empirical vancomycin use did not provide significant benefit (OR 2.159, 95% CI 0.949-4.912). Conclusions: Ceftriaxone alone is not adequate in the management of pneumococcal meningitis due to penicillin-resistant pneumococci, which is a major concern worldwide. Although vancomycin showed a trend towards improving the prognosis of pneumococcal meningitis, significant correlation in statistical terms could not be established in this study. Thus, further studies are needed for the optimization of pneumococcal meningitis treatment. (C) 2013 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. All rights reserved.
Published: 2014

49. Measles

Author: Filiz Pehlivanoglu and Alpay Azap
Subjects: Pediatrics, medicine.medical_specialty, Attenuated vaccine, Koplik's spots, biology, business.industry, Incidence (epidemiology), medicine.disease, biology.organism_classification, Measles, Rash, Vitamin A deficiency, Measles virus, Pathognomonic, medicine, medicine.symptom, business
Abstract: Measles is one of the most contagious diseases, which can transmit via respiratory secretions. It is estimated that prior to the license of an effective vaccine, measles was causing more than 2 million deaths and between 15,000 and 60,000 cases of blindness annually worldwide. As a result of great efforts by international health organizations and local health authorities to increase the vaccination rate, the incidence of measles showed a substantial decrease in most parts of the world. Unfortunately, since 2007, epidemics involving thousands of people across Europe have occurred. Measles virus (MV) enters the body via respiratory epithelium at any point from the nose to the lower parts of the respiratory tract. The incubation period for measles is 10–14 days. Malaise, fever, anorexia, conjunctivitis, and respiratory symptoms such as cough and coryza (three “c” signs) are seen in the prodromal phase that usually lasts for 2 or 3 days, maximum 8 days. Koplik’s spots, bluish-gray particles on an erythematous base, occur on buccal mucosa approximately 48 hours prior to the characteristic skin rash. This enanthema is pathognomonic for measles but does not appear in all patients. A very safe, cheap, and effective live attenuated vaccine against measles has been available since the 1960s. Two doses of vaccine (first very early in the second year of life and second in early childhood) may provide long-lasting (life-long) immunity in 95% of vaccinated individuals. Treatment of measles mainly involves supportive therapy such as antipyretics and fluids as indicated. Vitamin A decreases the severity of measles especially in malnourished children suffering vitamin A deficiency. Patients with suspected or proven measles should be managed with airborne precautions during the “period of infectivity.”
Published: 2014

50. The microbiological diagnosis of tuberculous meningitis: results of Haydarpasa-1 study

Author: Ebru Kurşun, Derya Ozturk-Engin, Branislava Savic, Rok Čivljak, Bojana Beović, Mehmet Parlak, Elif Sahin-Horasan, Oguz Karabay, Selma Alabay, Emine Parlak, Esmeray Mutlu Yilmaz, Ahmad Khalifa, Uner Kayabas, Saim Dayan, Hakan Erdem, Sukran Kose, V Kirova, Jean-Paul Stahl, Gonul Sengoz, Bruno Cacopardo, Canan Agalar, Arjan Harxhi, Gorana Cosic, Yves Hansmann, Catalina Luca, Alpaslan Alp, Aysegul Ulu-Kilic, Mehmet Bitirgen, Kadriye Kart Yaşar, Özcan Deveci, Isik Somuncu Johansen, Mustafa Namiduru, Katell Andre, I Masse-Chabredier, H. Cem Gul, Serkan Oncu, Mustafa Sunbul, Akram Al-Mahdawi, Ayhan Akbulut, Gulden Yilmaz, Serda Gulsun, Oral Oncul, S Chadapaud, Soline Simeon, Melanie Catroux, Oğuz Reşat Sipahi, Recep Tekin, Ayşe Seza Inal, Mucahit Yemisen, Filiz Pehlivanoglu, Olga Dulovic, Asuman Inan, B. Lakatos, Bahar Kandemir, Nazif Elaldi, Ghaydaa A. Shehata, Ahmet Karakaş, Alper Şener, Mihai Nechifor, Muge Ozguler, Alexandru Crisan, Nurgul Ceran, Çukurova Üniversitesi, OMÜ, Ege Üniversitesi, [Erdem, H. -- Oncul, O.] GATA Haydarpasa Training Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Ozturk-Engin, D. -- Inan, A. -- Ceran, N.] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Elaldi, N.] Cumhuriyet Univ Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Gulsun, S.] Diyarbakir Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Sengoz, G. -- Pehlivanoglu, F.] Haseki Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Crisan, A.] Victor Babes Univ Med & Pharm, Dept Infect Dis, Timisoara, Romania -- [Johansen, I. S.] Odense Univ Hosp, Dept Infect Dis Q, DK-5000 Odense, Denmark -- [Nechifor, M.] Gr T Popa Univ Med & Pharm, Dept Pharmacol, Iasi, Romania -- [Al-Mahdawi, A.] Baghdad Teaching Hosp, Dept Neurol, Baghdad, Iraq -- [Civljak, R.] Univ Zagreb Sch Med, Dr Fran Mihaljev Univ Hosp Infect Dis, Dept Infect Dis, Zagreb, Croatia -- [Ozguler, M. -- Akbulut, A.] Firat Univ Sch Med, Dept Infect Dis & Clin Microbiol, Elazig, Turkey -- [Savic, B.] Univ Belgrade, Inst Microbiol & Immunol, Natl Reference Lab TB, Fac Med, Belgrade, Serbia -- [Cacopardo, B.] Univ Catania, Infect Dis Sect, Dept Clin & Mol Biomed, Catania, Italy -- [Inal, A. S.] Cukurova Univ Sch Med, Dept Infect Dis & Clin Microbiol, Adana, Turkey -- [Namiduru, M.] Gaziantep Univ Sch Med, Dept Infect Dis & Clin Microbiol, Gaziantep, Turkey -- [Dayan, S. -- Tekin, R. -- Deveci, O.] Dicle Univ Sch Med, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Kayabas, U.] Inonu Univ Sch Med, Dept Infect Dis & Clin Microbiol, Malatya, Turkey -- [Parlak, E. -- Parlak, M.] Ataturk Univ Sch Med, Dept Infect Dis & Clin Microbiol, Erzurum, Turkey -- [Khalifa, A.] Damascus Hosp, Dept Neurol, Damascus, Syria -- [Kursun, E.] Baskent Univ Sch Med, Dept Infect Dis & Clin Microbiol, Adana, Turkey -- [Sipahi, O. R.] Ege Univ Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Yemisen, M.] Istanbul Univ Cerrahpasa Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Bitirgen, M. -- Kandemir, B.] Necmettin Erbakan Univ Sch Med, Dept Infect Dis & Clin Microbiol, Konya, Turkey -- [Dulovic, O.] Univ Belgrade, Clin Infect & Trop Dis, Clin Ctr Serbia, Fac Med, Belgrade, Serbia -- [Luca, C.] Gr T Popa Univ Med & Pharm, Dept Infect Dis, Iasi, Romania -- [Stahl, J. P.] Joseph Fourier Univ & Univ Hosp Grenoble, Dept Infect Dis, Grenoble, France -- [Simeon, S.] Univ Hosp Pontchaillou, Dept Infect & Trop Dis, Rennes, France -- [Ulu-Kilic, A. -- Alabay, S.] Erciyes Univ Sch Med, Dept Infect Dis & Clin Microbiol, Kayseri, Turkey -- [Yasar, K.] Bakrkoy Dr Sadi Konuk Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Yilmaz, G.] Ankara Univ Sch Med, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Yilmaz, E.] Uludag Univ Sch Med, Dept Infect Dis & Clin Microbiol, Bursa, Turkey -- [Beovic, B.] Univ Med Ctr, Dept Infect Dis, Ljubljana, Slovenia -- [Catroux, M.] Univ Poitiers Hosp, Dept Infect Dis, Poitiers, France -- [Lakatos, B.] St Laszlo Hosp, Dept Infect Dis, Budapest, Hungary -- [Sunbul, M.] Ondokuz Mayis Univ Sch Med, Dept Infect Dis & Clin Microbiol, Samsun, Turkey -- [Sahin-Horasan, E.] Mersin Univ Sch Med, Dept Infect Dis & Clin Microbiol, Mersin, Turkey -- [Kose, S.] Tepecik Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Shehata, G.] Assiut Univ Hosp, Dept Neurol & Psychiat, Assiut, Egypt -- [Andre, K.] Dax Hosp, Dept Infect Dis, Dax, France -- [Alp, A.] Hacettepe Univ, Sch Med, Deparment Med Microbiol, Ankara, Turkey -- [Cosic, G.] Univ Novi Sad, Fac Med, Dept Prevent & Control Dis, IPH Vojvodina, Novi Sad, Serbia -- [Gul, H. Cem -- Karakas, A.] Gulhane Mil Med Acad, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Chadapaud, S.] Marie Jose Treffot Hosp, Dept Infect Dis, Hyeres, France -- [Hansmann, Y.] Univ Hosp, Dept Infect Dis, Strasbourg, France -- [Harxhi, A.] Univ Hosp Ctr Tirana, Infect Dis Serv, Tirana, Albania -- [Kirova, V.] Univ Clin Infect Dis & Febrile Condit, Skopje, Macedonia -- [Masse-Chabredier, I.] Aurillac Hosp, Dept Infect Dis, Aurillac, France -- [Oncu, S.] Adnan Menderes Univ Sch Med, Dept Infect Dis & Clin Microbiol, Aydin, Turkey -- [Sener, A.] Onsekiz Mart Univ Sch Med, Dept Infect Dis & Clin Microbiol, Canakkale, Turkey -- [Karabay, O.] Sakarya Univ Sch Med, Dept Infect Dis & Clin Microbiol, Sakarya, Turkey -- [Agalar, C.] Fatih Sultan Mehmet Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey, Inal, Ayse Seza -- 0000-0002-1182-7164, Ghaydaa, Shehata -- 0000-0002-3631-893X, johansen, isik somuncu -- 0000-0002-2189-9823, Karabay, Oguz -- 0000-0003-0502-432X, Karakas, Ahmet -- 0000-0002-0553-8454, Kart Yasar, Kadriye -- 0000-0003-2963-4894, Stahl, Jean Paul -- 0000-0002-0086-3557, Elaldi, Nazif -- 0000-0002-9515-770X, ALP, ALPASLAN -- 0000-0001-7856-7590, and Civljak, Rok -- 0000-0001-8766-7438
Subjects: Microbiology (medical), Adult, Male, medicine.medical_specialty, Adolescent, QUANTIFERON-TB GOLD, diagnosis, Adenosine Deaminase, Culture, Tuberculous meningitis, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Internal medicine, Diagnosis, medicine, Tuberculosis, Humans, Meningitis, 030212 general & internal medicine, Precision Medicine, Aged, Retrospective Studies, culture, meningitis, PCR, tuberculosis, Aged, 80 and over, Bacteriological Techniques, business.industry, General Medicine, Mycobacterium tuberculosis, Middle Aged, medicine.disease, 3. Good health, Surgery, Löwenstein–Jensen medium, Infectious Diseases, Early Diagnosis, Tuberculosis, Meningeal, Positive culture, Female, business, 030217 neurology & neurosurgery, Interferon-gamma Release Tests
Abstract: WOS: 000345825900004, PubMed ID: 24849547, We aimed to provide data on the diagnosis of tuberculous meningitis (TBM) in this largest case series ever reported. The Haydarpasa-1 study involved patients with microbiologically confirmed TBM in Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia, Syria and Turkey between 2000 and 2012. A positive culture, PCR or Ehrlich-Ziehl-Neelsen staining (EZNs) from the cerebrospinal fluid (CSF) was mandatory for inclusion of meningitis patients. A total of 506 TBM patients were included. The sensitivities of the tests were as follows: interferon- release assay (Quantiferon TB gold in tube) 90.2%, automated culture systems (ACS) 81.8%, Lowenstein Jensen medium (L-J) 72.7%, adenosine deaminase (ADA) 29.9% and EZNs 27.3%. CSF-ACS was superior to CSF L-J culture and CSF-PCR (p
Published: 2013

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