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The Institute for Healthcare Improvement Framework for Improving Joy at Work includes self-care as a strategy to support happy, healthy, and productive people; however, this relationship has not previously been empirically demonstrated. The purpose of this study was to describe self-care practices and levels of meaning and joy in work (MJW) in a sample of registered nurses and to explore the relationship between self-care and MJW. Registered nurses (n = 122) from a regional health system completed a survey during a nursing recognition event. Measures included a Demographic Questionnaire, the Meaning and Joy in Work Questionnaire (MJWQ), and the Brief Mindful Self-Care Scale (Brief MSCS). The mean MJWQ score was 4.29 on a scale of 1 to 5, and the mean Brief MSCS score was 3.05. There was a significant relationship between MJWQ and Brief MSCS scores ( r  = 0.43, P  < .001). These results indicate that supporting self-care in nurses may improve MJW., Competing Interests: The authors have no conflicts of interest to disclose., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)

The R 3 TiSb 5 ternary compounds, with R a light rare earth (La to Sm) have been reported to crystallize with the anti-Hf 5 CuSn 3 -type hexagonal structure (Pearson's symbol hP 18; space-group P 6 3 / mcm , N. 193). An early article that reported possible superconductivity in some of these intermetallic phases (namely those with R = La, Ce, and Nd) caught our attention. In this work, we have now refined the crystal structure of the R 3 TiSb 5 compounds with R = Ce, Pr and Nd by Rietveld methods using high-resolution neutron powder diffraction data. The magnetic ground states of these intermetallics have been investigated by low-temperature magnetization and high-intensity neutron diffraction. We find two different magnetic transitions corresponding to two related magnetic structures at T N1 = 4.8 K ( k 1 = [0, 1/2, 1/8]) and T N2 = 3.4 K ( k 2 = [0, 0, 1/8]), respectively for Ce 3 TiSb 5 . However, the magnetic ordering appears to occur following a peculiar hysteresis: the k 2 -type magnetic structure develops only after the k 1 -type phase fraction has first slowly ordered with time and the size of the ordered Ce 3+ magnetic moment has become large enough to induce the second magnetic transition. At T = 1.5 K the maximum amplitude of the Ce moment in the coexisting phases amounts to μ Ce = 2.15  μ B . For Nd 3 TiSb 5 an antiferromagnetic ordering below T N = 5.2 K into a relatively simpler commensurate magnetic structure with a magnetic moment of μ Nd = 2.14(3) μ B and magnetic propagation vector of k = [0, 0, 0], was determined. No evidence of superconductivity has been found in Nd 3 TiSb 5 . Finally, Pr 3 TiSb 5 does not show any ordering down to 1.5 K in neutron diffraction while an antiferromagnetic ground state is detected in magnetization measurements. There is no sign of magnetic contribution from Ti atoms found in any of the studied compounds., (© 2021 IOP Publishing Ltd.)

Purpose: To explore the role of vacuum assisted closure (VAC) therapy versus conventional dressings in the Fournier's gangrene wound therapy., Patients and Methods: This is a retrospective multi-institutional cohort study. Data of 92 patients from nine centers between 2007 and 2018 were retrospectively analyzed. After surgery, patient having a local or a disseminated FG were managed with VAC therapy or with conventional dressings. The 10-weeks wound closure cumulative rate and OS were analyzed., Results: Of the 92 patients, 62 (67.4%) showed local and 30 (32.6%) a disseminated FG. After surgery, 19 patients (20.7%) with local and 14 (15.2%) with disseminated FG underwent to VAC therapy; 43 (46.7%) with local and 16 (17.4%) with disseminated FG were treated using conventional dressings. The multivariable logistic regression analysis demonstrated that the VAC in patients with disseminated FG led to a higher cumulative rate of wound closure than patients treated with no-VAC (OR = 6.5; 95% CI 1.1-37.4, p = 0.036). The Kaplan-Meier survival curves for the OS showed a significant difference between no-VAC patients with local and disseminated FG (OS rate at 90 days 0.90, 95% CI 0.71-0.97 vs 0.55, 95% CI 0.24-0.78, respectively; p = 0.039). Cox regression confirmed that no-VAC patients with disseminated FG showed the lowest OS (hazard ratio adjusted for sex and age HR = 3.4, 95% CI 1.1-10.4; p = 0.033)., Conclusions: In this large cohort study, VAC therapy in patients with disseminated FG may offer an advantage in terms of 10-weeks wound closure cumulative rate and OS at 90 days after initial surgery.

The Winnie mouse, carrying a missense mutation in Muc2, is a model for chronic intestinal inflammation demonstrating symptoms closely resembling inflammatory bowel disease (IBD). Alterations to the immune environment, morphological structure, and innervation of Winnie mouse colon have been identified; however, analyses of intestinal transit and colonic functions have not been conducted. In this study, we investigated in vivo intestinal transit in radiographic studies and in vitro motility of the isolated colon in organ bath experiments. We compared neuromuscular transmission using conventional intracellular recording between distal colon of Winnie and C57BL/6 mice and smooth muscle contractions using force displacement transducers. Chronic inflammation in Winnie mice was confirmed by detection of lipocalin-2 in fecal samples over 4 wk and gross morphological damage to the colon. Colonic transit was faster in Winnie mice. Motility was altered including decreased frequency and increased speed of colonic migrating motor complexes and increased occurrence of short and fragmented contractions. The mechanisms underlying colon dysfunctions in Winnie mice included inhibition of excitatory and fast inhibitory junction potentials, diminished smooth muscle responses to cholinergic and nitrergic stimulation, and increased number of α-smooth muscle actin-immunoreactive cells. We conclude that diminished excitatory responses occur both prejunctionally and postjunctionally and reduced inhibitory purinergic responses are potentially a prejunctional event, while diminished nitrergic inhibitory responses are probably due to a postjunction mechanism in the Winnie mouse colon. Many of these changes are similar to disturbed motor functions in IBD patients indicating that the Winnie mouse is a model highly representative of human IBD., New & Noteworthy: This is the first study to provide analyses of intestinal transit and whole colon motility in an animal model of spontaneous chronic colitis. We found that cholinergic and purinergic neuromuscular transmission, as well as the smooth muscle cell responses to cholinergic and nitrergic stimulation, is altered in the chronically inflamed Winnie mouse colon. The changes to intestinal transit and colonic function we identified in the Winnie mouse are similar to those seen in inflammatory bowel disease patients., (Copyright © 2017 the American Physiological Society.)