5 results on '"Filipovic, Igor"'
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2. Improved reference genome of Aedes aegypti informs arbovirus vector control
- Author
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Matthews, Benjamin J., Dudchenko, Olga, Kingan, Sarah B., Koren, Sergey, Antoshechkin, Igor, Crawford, Jacob E., Glassford, William J., Herre, Margaret, Redmond, Seth N., Rose, Noah H., Weedall, Gareth D., Wu, Yang, Batra, Sanjit S., Brito-Sierra, Carlos A., Buckingham, Steven D., Campbell, Corey L., Chan, Saki, Cox, Eric, Evans, Benjamin R., Fansiri, Thanyalak, Filipovic, Igor, Fontaine, Albin, Gloria-Soria, Andrea, Hall, Richard, Joardar, Vinita S., Jones, Andrew K., Kay, Raissa G. G., Kodali, Vamsi K., Lee, Joyce, Lycett, Gareth J., Mitchell, Sara N., Muehling, Jill, Murphy, Michael R., Omer, Arina D., Partridge, Frederick A., Peluso, Paul, Aiden, Aviva Presser, Ramasamy, Vidya, Rasic, Gordana, Roy, Sourav, Saavedra-Rodriguez, Karla, Sharan, Shruti, Sharma, Atashi, Smith, Melissa Laird, Turner, Joe, Weakley, Allison M., Zhao, Zhilei, Akbari, Omar S., Black, William C., Cao, Han, Darby, Alistair C., Hill, Catherine A., Johnston, J. Spencer, Murphy, Terence D., Raikhel, Alexander S., Sattelle, David B., Sharakhov, Igor V., White, Bradley J., Zhao, Li, Aiden, Erez Lieberman, Mann, Richard S., Lambrechts, Louis, Powell, Jeffrey R., Sharakhova, Maria V., Tu, Zhijian Jake, Robertson, Hugh M., McBride, Carolyn S., Hastic, Alex R., Korlach, Jonas, Neafsey, Daniel E., Phillippy, Adam M., Vosshall, Leslie B., Matthews, Benjamin J., Dudchenko, Olga, Kingan, Sarah B., Koren, Sergey, Antoshechkin, Igor, Crawford, Jacob E., Glassford, William J., Herre, Margaret, Redmond, Seth N., Rose, Noah H., Weedall, Gareth D., Wu, Yang, Batra, Sanjit S., Brito-Sierra, Carlos A., Buckingham, Steven D., Campbell, Corey L., Chan, Saki, Cox, Eric, Evans, Benjamin R., Fansiri, Thanyalak, Filipovic, Igor, Fontaine, Albin, Gloria-Soria, Andrea, Hall, Richard, Joardar, Vinita S., Jones, Andrew K., Kay, Raissa G. G., Kodali, Vamsi K., Lee, Joyce, Lycett, Gareth J., Mitchell, Sara N., Muehling, Jill, Murphy, Michael R., Omer, Arina D., Partridge, Frederick A., Peluso, Paul, Aiden, Aviva Presser, Ramasamy, Vidya, Rasic, Gordana, Roy, Sourav, Saavedra-Rodriguez, Karla, Sharan, Shruti, Sharma, Atashi, Smith, Melissa Laird, Turner, Joe, Weakley, Allison M., Zhao, Zhilei, Akbari, Omar S., Black, William C., Cao, Han, Darby, Alistair C., Hill, Catherine A., Johnston, J. Spencer, Murphy, Terence D., Raikhel, Alexander S., Sattelle, David B., Sharakhov, Igor V., White, Bradley J., Zhao, Li, Aiden, Erez Lieberman, Mann, Richard S., Lambrechts, Louis, Powell, Jeffrey R., Sharakhova, Maria V., Tu, Zhijian Jake, Robertson, Hugh M., McBride, Carolyn S., Hastic, Alex R., Korlach, Jonas, Neafsey, Daniel E., Phillippy, Adam M., and Vosshall, Leslie B.
- Abstract
Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of mosquitoes and developing the tools to fight them has been slowed by the lack of a high-quality genome assembly. Here we combine diverse technologies to produce the markedly improved, fully re-annotated AaegL5 genome assembly, and demonstrate how it accelerates mosquito science. We anchored physical and cytogenetic maps, doubled the number of known chemosensory ionotropic receptors that guide mosquitoes to human hosts and egg-laying sites, provided further insight into the size and composition of the sex-determining M locus, and revealed copy-number variation among glutathione S-transferase genes that are important for insecticide resistance. Using high-resolution quantitative trait locus and population genomic analyses, we mapped new candidates for dengue vector competence and insecticide resistance. AaegL5 will catalyse new biological insights and intervention strategies to fight this deadly disease vector.
- Published
- 2018
- Full Text
- View/download PDF
3. Improved reference genome of Aedes aegypti informs arbovirus vector control
- Author
-
Biochemistry, Entomology, Fralin Life Sciences Institute, Matthews, Benjamin J., Dudchenko, Olga, Kingan, Sarah B., Koren, Sergey, Antoshechkin, Igor, Crawford, Jacob E., Glassford, William J., Herre, Margaret, Redmond, Seth N., Rose, Noah H., Weedall, Gareth D., Wu, Yang, Batra, Sanjit S., Brito-Sierra, Carlos A., Buckingham, Steven D., Campbell, Corey L., Chan, Saki, Cox, Eric, Evans, Benjamin R., Fansiri, Thanyalak, Filipovic, Igor, Fontaine, Albin, Gloria-Soria, Andrea, Hall, Richard, Joardar, Vinita S., Jones, Andrew K., Kay, Raissa G. G., Kodali, Vamsi K., Lee, Joyce, Lycett, Gareth J., Mitchell, Sara N., Muehling, Jill, Murphy, Michael R., Omer, Arina D., Partridge, Frederick A., Peluso, Paul, Aiden, Aviva Presser, Ramasamy, Vidya, Rasic, Gordana, Roy, Sourav, Saavedra-Rodriguez, Karla, Sharan, Shruti, Sharma, Atashi, Smith, Melissa Laird, Turner, Joe, Weakley, Allison M., Zhao, Zhilei, Akbari, Omar S., Black, William C., Cao, Han, Darby, Alistair C., Hill, Catherine A., Johnston, J. Spencer, Murphy, Terence D., Raikhel, Alexander S., Sattelle, David B., Sharakhov, Igor V., White, Bradley J., Zhao, Li, Aiden, Erez Lieberman, Mann, Richard S., Lambrechts, Louis, Powell, Jeffrey R., Sharakhova, Maria V., Tu, Zhijian Jake, Robertson, Hugh M., McBride, Carolyn S., Hastic, Alex R., Korlach, Jonas, Neafsey, Daniel E., Phillippy, Adam M., Vosshall, Leslie B., Biochemistry, Entomology, Fralin Life Sciences Institute, Matthews, Benjamin J., Dudchenko, Olga, Kingan, Sarah B., Koren, Sergey, Antoshechkin, Igor, Crawford, Jacob E., Glassford, William J., Herre, Margaret, Redmond, Seth N., Rose, Noah H., Weedall, Gareth D., Wu, Yang, Batra, Sanjit S., Brito-Sierra, Carlos A., Buckingham, Steven D., Campbell, Corey L., Chan, Saki, Cox, Eric, Evans, Benjamin R., Fansiri, Thanyalak, Filipovic, Igor, Fontaine, Albin, Gloria-Soria, Andrea, Hall, Richard, Joardar, Vinita S., Jones, Andrew K., Kay, Raissa G. G., Kodali, Vamsi K., Lee, Joyce, Lycett, Gareth J., Mitchell, Sara N., Muehling, Jill, Murphy, Michael R., Omer, Arina D., Partridge, Frederick A., Peluso, Paul, Aiden, Aviva Presser, Ramasamy, Vidya, Rasic, Gordana, Roy, Sourav, Saavedra-Rodriguez, Karla, Sharan, Shruti, Sharma, Atashi, Smith, Melissa Laird, Turner, Joe, Weakley, Allison M., Zhao, Zhilei, Akbari, Omar S., Black, William C., Cao, Han, Darby, Alistair C., Hill, Catherine A., Johnston, J. Spencer, Murphy, Terence D., Raikhel, Alexander S., Sattelle, David B., Sharakhov, Igor V., White, Bradley J., Zhao, Li, Aiden, Erez Lieberman, Mann, Richard S., Lambrechts, Louis, Powell, Jeffrey R., Sharakhova, Maria V., Tu, Zhijian Jake, Robertson, Hugh M., McBride, Carolyn S., Hastic, Alex R., Korlach, Jonas, Neafsey, Daniel E., Phillippy, Adam M., and Vosshall, Leslie B.
- Abstract
Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of mosquitoes and developing the tools to fight them has been slowed by the lack of a high-quality genome assembly. Here we combine diverse technologies to produce the markedly improved, fully re-annotated AaegL5 genome assembly, and demonstrate how it accelerates mosquito science. We anchored physical and cytogenetic maps, doubled the number of known chemosensory ionotropic receptors that guide mosquitoes to human hosts and egg-laying sites, provided further insight into the size and composition of the sex-determining M locus, and revealed copy-number variation among glutathione S-transferase genes that are important for insecticide resistance. Using high-resolution quantitative trait locus and population genomic analyses, we mapped new candidates for dengue vector competence and insecticide resistance. AaegL5 will catalyse new biological insights and intervention strategies to fight this deadly disease vector.
- Published
- 2018
4. JUST BREATHE: USING SIMPLE RESPIROMETRY TO CHARACTERIZE METABOLIC RESISTANCE TO INSECTICIDES IN MOSQUITO VECTORS
- Author
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Gordana Rašić, Filipovic, Igor, Rigby, Lisa, Manrique-Saide, Pablo, and Devine, Gregor
5. Extensive Genetic Differentiation between Homomorphic Sex Chromosomes in the Mosquito Vector, Aedes aegypti.
- Author
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Fontaine A, Filipovic I, Fansiri T, Hoffmann AA, Cheng C, Kirkpatrick M, Rašic G, and Lambrechts L
- Subjects
- Aedes physiology, Animals, Genes, Insect, Genetic Drift, Genetic Linkage, Genetic Loci, Genome, Insect, Recombination, Genetic, Sex Characteristics, Aedes genetics, Chromosomes, Insect, Sex Chromosomes
- Abstract
Mechanisms and evolutionary dynamics of sex-determination systems are of particular interest in insect vectors of human pathogens like mosquitoes because novel control strategies aim to convert pathogen-transmitting females into nonbiting males, or rely on accurate sexing for the release of sterile males. In Aedes aegypti, the main vector of dengue and Zika viruses, sex determination is governed by a dominant male-determining locus, previously thought to reside within a small, nonrecombining, sex-determining region (SDR) of an otherwise homomorphic sex chromosome. Here, we provide evidence that sex chromosomes in Ae. aegypti are genetically differentiated between males and females over a region much larger than the SDR. Our linkage mapping intercrosses failed to detect recombination between X and Y chromosomes over a 123-Mbp region (40% of their physical length) containing the SDR. This region of reduced male recombination overlapped with a smaller 63-Mbp region (20% of the physical length of the sex chromosomes) displaying high male-female genetic differentiation in unrelated wild populations from Brazil and Australia and in a reference laboratory strain originating from Africa. In addition, the sex-differentiated genomic region was associated with a significant excess of male-to-female heterozygosity and contained a small cluster of loci consistent with Y-specific null alleles. We demonstrate that genetic differentiation between sex chromosomes is sufficient to assign individuals to their correct sex with high accuracy. We also show how data on allele frequency differences between sexes can be used to estimate linkage disequilibrium between loci and the sex-determining locus. Our discovery of large-scale genetic differentiation between sex chromosomes in Ae. aegypti lays a new foundation for mapping and population genomic studies, as well as for mosquito control strategies targeting the sex-determination pathway., (© The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.)
- Published
- 2017
- Full Text
- View/download PDF
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