276 results on '"Filipovic, D."'
Search Results
2. Automated template matching versus conventional pace-mapping during pvc ablation: results from a randomized controlled trial
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Schulz, N, primary, Steven, D, additional, Sultan, A, additional, Van Den Bruck, J H, additional, Woermann, J, additional, Schipper, J, additional, Scheurlen, C, additional, Dittrich, S, additional, Filipovic, D, additional, Erlhoefer, S, additional, and Lueker, J, additional
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- 2024
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3. Thin-shell-theory solutions for the static structural response of circular-sections shaped corrugated laminates
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Moro, A., Filipovic, D., Kress, G., and Winkler, M.
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- 2020
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4. Exact model for the response of moderately thick laminates to transverse forces
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Kress, G. and Filipovic, D.
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- 2019
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5. Manufacturing method for high-amplitude corrugated thin-walled laminates
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Filipovic, D. and Kress, G.
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- 2019
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6. Affine Processes and Applications in Finance
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Duffie, D., Filipović, D., and Schachermayer, W.
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- 2003
7. Protein dynamics. Comparative investigation on heme-proteins with different physiological roles
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Di Iorio, EE, Hiltpold, UR, Filipovic, D, Winterhalter, KH, Gratton, E, Vitrano, E, Cupane, A, Leone, M, and Cordone, L
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Chemical Sciences ,Physical Chemistry ,Theoretical and Computational Chemistry ,Animals ,Biophysical Phenomena ,Biophysics ,Carbon Monoxide ,Hemeproteins ,Hemoglobin A ,Humans ,In Vitro Techniques ,Kinetics ,Myoglobin ,Photolysis ,Spectrophotometry ,Thermodynamics ,Physical Sciences ,Biological Sciences ,Biological sciences ,Chemical sciences ,Physical sciences - Abstract
We report the low temperature carbon monoxide recombination kinetics after photolysis and the temperature dependence of the visible absorption spectra of the isolated alpha SH-CO and beta SH-CO subunits from human hemoglobin A in ethylene glycol/water and in glycerol/water mixtures. Kinetic measurements on sperm whale (Physeter catodon) myoglobin and previously published optical spectroscopy data on the latter protein and on human hemoglobin A, in both solvents, (Cordone, L., A. Cupane, M. Leone, E. Vitrano, and D. Bulone. 1988. J. Mol. Biol. 199:312-218) are taken as reference. Low temperature flash photolysis data are analyzed within the multiple substates model proposed by Frauenfelder and co-workers (Austin, R. H., K. W. Beeson, L. Eisenstein, H. Frauenfelder, and I. C. Gunsalus. 1975. Biochemistry. 14:5355-5373). Within this model a distribution of activation enthalpies for ligand binding accounts for the structural heterogeneity of the protein, while the preexponential factor, containing also the entropic contribution to the free energy of the process, is considered to be constant for all conformational substates. Optical spectra are deconvoluted in gaussian components and the temperature dependence of the moments of the resulting bands is analyzed, within the harmonic Frank-Condon approximation, to obtain information on the stereodynamic properties of the heme pocket. The kinetic and spectral parameters thus obtained are found to be protein dependent also with respect to their sensitivity to changes in the composition of the external medium. A close correlation between the kinetic and spectral features is observed for the proteins examined under all experimental conditions studied. The results reported are discussed in terms of differences in the heme pocket structure and in the conformational heterogeneity among the various proteins, as related to their different capability to accommodate constraints imposed by the external medium.
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- 1991
8. The differential effects of acute vs. chronic stress and their combination on hippocampal parvalbumin and inducible heat shock protein 70 expression
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Filipović, D., Zlatković, J., Gass, P., and Inta, D.
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- 2013
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9. Significant increase in anxiety during aging in mGlu5 receptor knockout mice
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Inta, D., Vogt, M.A., Luoni, A., Filipović, D., Lima-Ojeda, J.M., Pfeiffer, N., Gasparini, F., Riva, M.A., and Gass, P.
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- 2013
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10. Affine Short Rate Models
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Filipović, D., Liggett, Thomas, editor, Newman, Charles, editor, Pitt, Loren, editor, Dalang, Robert C., editor, Dozzi, Marco, editor, and Russo, Francesco, editor
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- 2002
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11. Bax and B-cell-lymphoma 2 mediate proapoptotic signaling following chronic isolation stress in rat brain
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ZLATKOVIĆ, J. and FILIPOVIĆ, D.
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- 2012
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12. Auditory Event-Related P300 Potentials in Rheumatoid Arthritis Patients
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Tomasevic-Todorovic, S., Boskovic, K., Filipovic, D., Milekic, B., Grajic, M., and Hanna, F.
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- 2015
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13. Design of a Circularly-Polarized Tightly-Coupled Microstrip Patch Array
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Son, D.-C., primary, Samaiyar, A., additional, Elmansouri, M. A., additional, and Filipovic, D. S., additional
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- 2021
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14. Reduction of mouldboard plough share wear by a combination technique of hardfacing
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Horvat, Z., Filipovic, D., Kosutic, S., and Emert, R.
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- 2008
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15. New AMS 14C dates track the arrival and spread of broomcorn millet cultivation and agricultural change in prehistoric Europe
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Filipovic, D., Meadows, J., Corso, M. D., Kirleis, W., Alsleben, A., Akeret, O., Bittmann, F., Bosi, G., Ciuta, B., Dreslerova, D., Effenberger, H., Gyulai, F., Heiss, A. G., Hellmund, M., Jahns, S., Jakobitsch, T., Kapcia, M., Klooss, S., Kohler-Schneider, M., Kroll, H., Makarowicz, P., Marinova, E., Markle, T., Medovic, A., Mercuri, A. M., Mueller-Bieniek, A., Nisbet, R., Pashkevich, G., Perego, R., Pokorny, P., Pospieszny, L., Przybyla, M., Reed, K., Rennwanz, J., Stika, H. -P., Stobbe, A., Tolar, T., Wasylikowa, K., Wiethold, J., Zerl, T., Institut fûr Ur- und Frühgeschichte, Christian-Albrechts-Universität zu Kiel (CAU), Centre for Baltic and Scandinavian Archaeology (ZBSA), Schleswig-Holstein State Museums Foundation (ZBSA), Centre for Baltic and Scandinavian Archaeology (ZBSA), Integrative Prähistorische und Naturwissenschaftliche Archäologie, Basel, Niedersächsisches Institut für Historische Küstenforschung (NIHK), Dipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio EmiliaUniversità degli Studi di Modena e Reggio Emilia, Facultatea de Istorie şi Filologie, Universitatea '1 Decembrie 1918' Alba Iulia, Institute of Archaeology of the Czech Academy of Sciences, Prague, Austrian Archaeological Institute (ÖAI), Austrian Archaeological Institute (ÖAI), Austrian Academy of Sciences (ÖAI), Landesamt für Denkmalpflege und Archäologie Sachsen-Anhalt (LDA-LSA), Brandenburgisches Landesamt für Denkmalpflege und Archäologisches Landesmuseum, Archäologisches Landesamt Schleswig-Holstein, Faculty of Archaeology, Adam Mickiewicz University, Poznan, Landesamt für Denkmalpflege Baden-Württemberg, Museum of Vojvodina, Partenaires INRAE, Department of Palaeobotany, W. Szafer Institute of Botany, Polish Academy of Sciences, Archéologie, Terre, Histoire, Sociétés [Dijon] (ARTeHiS), Ministère de la Culture et de la Communication (MCC)-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Institut national de recherches archéologiques préventives (Inrap), Institut fur UR-und Frühgeschichte, and Universität zu Köln
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Europe ,Environmental social sciences ,Science ,Panicum, Archaeobotany, Europe, Neolithic, AMS dating ,Medicine ,Archaeobotany ,Neolithic ,Panicum ,AMS dating ,Plant sciences ,[SHS]Humanities and Social Sciences - Abstract
International audience; Broomcorn millet (Panicum miliaceum L.) is not one of the founder crops domesticated in Southwest Asia in the early Holocene, but was domesticated in northeast China by 6000 BC. In Europe, millet was reported in Early Neolithic contexts formed by 6000 BC, but recent radiocarbon dating of a dozen 'early' grains cast doubt on these claims. Archaeobotanical evidence reveals that millet was common in Europe from the 2nd millennium BC, when major societal and economic transformations took place in the Bronze Age. We conducted an extensive programme of AMS-dating of charred broomcorn millet grains from 75 prehistoric sites in Europe. Our Bayesian model reveals that millet cultivation began in Europe at the earliest during the sixteenth century BC, and spread rapidly during the fifteenth/fourteenth centuries BC. Broomcorn millet succeeds in exceptionally wide range of growing conditions and completes its lifecycle in less than three summer months. Offering an additional harvest and thus surplus food/fodder, it likely was a transformative innovation in European prehistoric agriculture previously based mainly on (winter) cropping of wheat and barley. We provide a new, high-resolution chronological framework for this key agricultural development that likely contributed to far-reaching changes in lifestyle in late 2nd millennium BC Europe.
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- 2020
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16. Mapping past human land use using archaeological data: A new classification for global land use synthesis and data harmonization
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Morrison, KD, Hammer, E, Boles, O, Madella, M, Whitehouse, N, Gaillard, MJ, Bates, J, Linden, MV, Merlo, S, Yao, A, Popova, L, Hill, AC, Antolin, F, Bauer, A, Biagetti, S, Bishop, RR, Buckland, P, Cruz, P, Dreslerová, D, Dusseldorp, G, Ellis, E, Filipovic, D, Foster, T, Hannaford, MJ, Harrison, SP, Hazarika, M, Herold, H, Hilpert, J, Kaplan, JO, Kay, A, Goldewijk, KK, Kolár, J, Kyazike, E, Laabs, J, Lancelotti, C, Lane, P, Lawrence, D, Lewis, K, Lombardo, U, Lucarini, G, Arroyo-Kalin, M, Marchant, R, Mayle, F, McClatchie, M, McLeester, M, Mooney, S, Moskal-Del Hoyo, M, Navarrete, V, Ndiema, E, Neves, EG, Nowak, M, Out, WA, Petrie, C, Phelps, LN, Pinke, Z, Rostain, S, Russell, T, Sluyter, A, Styring, AK, Tamanaha, E, Thomas, E, Veerasamy, S, Welton, L, Zanon, M, Morrison, KD, Hammer, E, Boles, O, Madella, M, Whitehouse, N, Gaillard, MJ, Bates, J, Linden, MV, Merlo, S, Yao, A, Popova, L, Hill, AC, Antolin, F, Bauer, A, Biagetti, S, Bishop, RR, Buckland, P, Cruz, P, Dreslerová, D, Dusseldorp, G, Ellis, E, Filipovic, D, Foster, T, Hannaford, MJ, Harrison, SP, Hazarika, M, Herold, H, Hilpert, J, Kaplan, JO, Kay, A, Goldewijk, KK, Kolár, J, Kyazike, E, Laabs, J, Lancelotti, C, Lane, P, Lawrence, D, Lewis, K, Lombardo, U, Lucarini, G, Arroyo-Kalin, M, Marchant, R, Mayle, F, McClatchie, M, McLeester, M, Mooney, S, Moskal-Del Hoyo, M, Navarrete, V, Ndiema, E, Neves, EG, Nowak, M, Out, WA, Petrie, C, Phelps, LN, Pinke, Z, Rostain, S, Russell, T, Sluyter, A, Styring, AK, Tamanaha, E, Thomas, E, Veerasamy, S, Welton, L, and Zanon, M
- Abstract
In the 12,000 years preceding the Industrial Revolution, human activities led to significant changes in land cover, plant and animal distributions, surface hydrology, and biochemical cycles. Earth system models suggest that this anthropogenic land cover change influenced regional and global climate. However, the representation of past land use in earth system models is currently oversimplified. As a result, there are large uncertainties in the current understanding of the past and current state of the earth system. In order to improve representation of the variety and scale of impacts that past land use had on the earth system, a global effort is underway to aggregate and synthesize archaeological and historical evidence of land use systems. Here we present a simple, hierarchical classification of land use systems designed to be used with archaeological and historical data at a global scale and a schema of codes that identify land use practices common to a range of systems, both implemented in a geospatial database. The classification scheme and database resulted from an extensive process of consultation with researchers worldwide. Our scheme is designed to deliver consistent, empirically robust data for the improvement of land use models, while simultaneously allowing for a comparative, detailed mapping of land use relevant to the needs of historical scholars. To illustrate the benefits of the classification scheme and methods for mapping historical land use, we apply it to Mesopotamia and Arabia at 6 kya (c. 4000 BCE). The scheme will be used to describe land use by the Past Global Changes (PAGES) LandCover6k working group, an international project comprised of archaeologists, historians, geographers, paleoecologists, and modelers. Beyond this, the scheme has a wide utility for creating a common language between research and policy communities, linking archaeologists with climate modelers, biodiversity conservation workers and initiatives.
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- 2021
17. Hand-transmitted vibration from the steering wheel to drivers of a small four-wheel drive tractor
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Goglia, V., Gospodaric, Z., Kosutic, S., and Filipovic, D.
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Ergonomics -- Research ,Automobile drivers -- Physiological aspects ,Vibration -- Physiological aspects ,Ergonomic aid ,Ergonomics ,Engineering and manufacturing industries ,Health ,Human resources and labor relations - Abstract
The paper presents research results of the vibration transmitted from the steering wheel of the small tractor with a 4-wheel drive to the driver's hands. The vibration measurements were carried out on the tractor randomly chosen from the producer's store-house. Before testing the tractor was examined and adjusted following the producer's recommendations. The vibration levels were measured at idling and at full load. The vibration level on the steering wheel was measured and analyzed and the frequency spectra for the chosen working conditions were obtained. The frequency-weighted acceleration, given in m/[s.sup.-2], was calculated. The vibration total value was defined as the root-mean-square of the three component values. The obtained values are graphically represented in accordance with ISO/DIS 5349-1979 and ISO5349-1-2001. The vibration exposure for the predicted 10% prevalance of vibration-induced white finger in accordance with Annex C of the same standard was also tested. Keywords: Ergonomics; Hand-transmitted vibration; Exposure limits
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- 2003
18. Physical Properties of Filbert Nut and Kernel
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Pliestic, S., Dobricevic, N., Filipovic, D., and Gospodaric, Z.
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- 2006
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19. Effects of tillage systems on compaction and crop yield of Albic Luvisol in Croatia
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Filipovic, D., Husnjak, S., Kosutic, S., and Gospodaric, Z.
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- 2006
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20. Ka-band Multi-beam Planar Lens Antenna for 5G Applications
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Garcia-Marin, E., primary, Filipovic, D. S., additional, Masa-Campos, J. L., additional, and Sanchez-Olivares, P., additional
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- 2020
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21. Correlation of open cell-attached and excised patch clamp techniques
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Filipovic, D. and Hayslett, J. P.
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- 1995
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22. Phased Array Antenna for Bi-Static Simultaneous Transmit and Receive (STAR) Systems
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Samaiyar, Aman, primary, Prasannakumar, Prathap Valale, additional, Elmansouri, M. A., additional, Boskovic, L., additional, Filipovic, D. S., additional, and Rao, Sudhakar, additional
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- 2019
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23. Bi-Static Simultaneous Transmit And Receive (STAR) Antenna Array System
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Prasannakumar, Prathap Valale, primary, Samaiyar, Aman, additional, Elmansouri, M. A., additional, Boskovic, L., additional, Filipovic, D. S., additional, and Rao, Sudhakar, additional
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- 2019
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24. Physical and mechanical characteristics of Hisex Brown hen eggs from three different housing systems
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Galic, A, primary, Filipovic, D, additional, Janjecic, Z, additional, Bedekovic, D, additional, Kovacev, I, additional, Copec, K, additional, and Pliestic, S, additional
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- 2019
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25. Some Physical, Morphological, and Mechanical Characteristics of Turkey (Meleagris gallopavo) Eggs
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Galic, A, primary, Pliestic, S, additional, Janjecic, Z, additional, Bedekovic, D, additional, Filipovic, D, additional, Kovacev, I, additional, and Copec, K, additional
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- 2018
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26. Affine Processes and Application in Finance
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Duffie, D., primary, Filipovic, D., additional, and Schachermayer, W., additional
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- 2002
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27. Half Ellipsoid Luneburg GRIN Dielectric Lens Loaded Double Ridged Horn Antenna
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Hoel, K.V., primary, Kristoffersen, S., additional, Ignatenko, M., additional, and Filipovic, D., additional
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- 2018
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28. Effects of specific allergen immunotherapy on biological markers and clinical parameters in asthmatic children: a controlled-real life study
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Djuric-Filipovic, I., primary, Caminati, Marco, additional, Filipovic, D., additional, Salvottini, C., additional, and Zivkovic, Z., additional
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- 2017
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29. Abstracts from the Food Allergy and Anaphylaxis Meeting 2016
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Pouessel, G, Claverie, C, Labreuche, J, Renaudin, J-M, Dorkenoo, A, Eb, M, Moneret-Vautrin, A, Deschildre, A, Leteurtre, S, Grabenhenrich, L, Worm, M, Dölle, S, Scherer, K, Hutteger, I, Christensen, M, Bindslev-Jensen, C, Mortz, C, Eller, E, Kjaer, HF, Carneiro-Leão, L, Badas, J, Coimbra, A, Levy, DP, Ben-Shoshan, M, Rimon, A, Benor, S, Arends, NJT, Edelbroek, N, de Groot, H, Emons, JAM, Brand, HKA, Verhoeven, D, van Veen, LN, de Jong, NW, Noh, G, Jang, EH, Pascal, M, Dominguez, O, Piquer, M, Alvaro, M, Jimenez-Feijoo, R, Lozano, J, Machinena, A, del Mar Folqué, M, Giner, MT, Plaza, AM, Turner, P, Patel, N, Vazquez-Ortiz, M, Lindsley, S, Walker, L, Rosenberg, S, Mari, A, Alessandri, C, Giangrieco, I, Tuppo, L, Rafaiani, C, Mitterer, G, Ciancamerla, M, Ferrara, R, Bernardi, ML, Zennaro, D, Tamburrini, M, Ciardiello, MA, Harwanegg, C, Fernandez, A, Selb, R, Egenmann, P, Epstein, M, Hoffmann-Sommergruber, K, Koning, F, Lovik, M, Clare Mills, EN, Moreno, J, van Loveren, H, Wal, J-M, Diesner, S, Bergmayr, C, Pfitzner, B, Assmann, VE, Starkl, P, Endesfelder, D, Eiwegger, T, Szepfalusi, Z, Fehrenbach, H, Jensen-Jarolim, E, Hartmann, A, Pali-Schöll, I, Untersmayr, E, Wille, S, Meyer, P, Klingebiel, C, Lidholm, J, Ehrenberg, A, Östling, J, Cleach, I, Mège, J-L, Vitte, J, Aina, R, Dubiela, P, Pfeifer, S, Bublin, M, Radauer, C, Humeniuk, P, Kabasser, S, Asero, R, Bogas, G, Gomez, F, Campo, P, Salas, M, Doña, I, Barrionuevo, E, Guerrero, MA, Mayorga, C, Prieto, A, Barber, D, Torres, MJ, Jamin, A, Wangorsch, A, Ballmer, B, Vieths, S, Scheurer, S, Apostolovic, D, Mihailovic, J, Krstic, M, Starkhammar, M, Velickovic, TC, Hamsten, C, van Hage, M, van Erp, FC, Knol, EF, Kansen, HM, Pontoppidan, B, Meijer, Y, van der Ent, CK, Knulst, AC, Sayers, R, Brown, H, Custovic, A, Simpson, A, Mills, C, Schulz, J, Akkerdaas, J, Totis, M, Capt, A, Herouet-Guicheney, C, van Ree, R, Banerjee, T, Banerjee, A, Claude, M, Bouchaud, G, Lupi, R, Castan, L, Tranquet, O, Denery-Papini, S, Bodinier, M, Brossard, C, De Poi, R, Gritti, E, De Dominicis, E, Popping, B, de Laureto, PP, Palosuo, K, Kukkonen, AK, Pelkonen, A, Mäkelä, M, Lee, NA, Rost, J, Muralidharan, S, Campbell, D, Mehr, S, Nock, C, Baumert, J, Taylor, S, Mastrorilli, C, Tripodi, S, Caffarelli, C, Perna, S, Di Rienzo Businco, A, Sfika, I, Dondi, A, Bianchi, A, Dascola, CP, Ricci, G, Cipriani, F, Maiello, N, del Giudice, MM, Frediani, T, Frediani, S, Macrì, F, Pistoletti, C, Iacono, ID, Patria, MF, Varin, E, Peroni, D, Comberiati, P, Chini, L, Moschese, V, Lucarelli, S, Bernardini, R, Pingitore, G, Pelosi, U, Olcese, R, Moretti, M, Cirisano, A, Faggian, D, Travaglini, A, Plebani, M, Verga, MC, Calvani, M, Giordani, P, Matricardi, PM, Ontiveros, N, Cabrera-Chavez, F, Galand, J, Beaudouin, E, Pineau, F, Sakai, S, Matsunaga, K, Teshima, R, Larré, C, Denery, S, Tschirner, S, Trendelenburg, V, Schulz, G, Niggemann, B, Beyer, K, Bouferkas, Y, Belabbas, Y, Saidi, D, Kheroua, O, Mecherfi, KEE, Guendouz, M, Haddi, A, Kaddouri, H, Amaral, L, Pereira, A, Rodrigues, S, Datema, M, Jongejan, L, Clausen, M, Knulst, A, Papadopoulos, N, Kowalski, M, de Blay, F, Zwinderman, A, Hoffman-Sommergruber, K, Ballmer-Weber, B, Fernandez-Rivas, M, Deng, S, Yin, J, Eisenmann, C, Nassiri, M, Reinert, R, van der Valk, JPM, van Wijk, RG, Vergouwe, Y, Steyerberg, EW, Reitsma, M, Wichers, HJ, Savelkoul, HFJ, Vlieg-Boerstra, B, Dubois, AEJ, Carolino, F, Rodolfo, A, Cernadas, J, Roa-Medellín, D, Rodriguez-Fernandez, A, Navarro, J, Albendiz, V, Baeza, ML, Intente-Herrero, S, Mikkelsen, A, Mehlig, K, Lissner, L, Verrill, L, Luccioli, S, van Bilsen, J, Kuper, F, Wolterbeek, A, Rankouhi, TR, Verschuren, L, Cnossen, H, Jeurink, P, Garssen, J, Knippels, L, Garthoff, J, Houben, G, Leeman, W, Eleonore Pettersson, M, Schins, AMM, Koppelman, GH, Kollen, BJ, Zubchenko, S, Kuntz, S, Mérida, P, Álvaro, M, Riggioni, C, Castellanos, JH, Jimenez, R, Cap, M, Drumez, E, Lejeune, S, Thumerelle, C, Mordacq, C, Nève, V, Ricò, S, Varini, M, Nocerino, R, Cosenza, L, Amoroso, A, Di Costanzo, M, Di Scala, C, Bedogni, G, Canani, RB, Turner, PJ, Poza-Guedes, P, González-Pérez, R, Sánchez-Machín, I, Matheu-Delgado, V, Wambre, E, Ballegaard, A-S, Madsen, C, Gregersen, J, Bøgh, KL, Aubert, P, Neunlist, M, Magnan, A, Lozano-Ojalvo, D, Pablos-Tanarro, A, Pérez-Rodríguez, L, Molina, E, López-Fandiño, R, Rekima, A, Macchiaverni, P, Turfkruyer, M, Holvoet, S, Dupuis, L, Baiz, N, Annesi-Maesano, I, Mercenier, A, Nutten, S, Verhasselt, V, Mrakovcic-Sutic, I, Banac, S, Sutic, I, Baricev-Novakovic, Z, Pavisic, V, Muñoz-Cano, R, Jiménez-Rodríguez, T, Corbacho, D, Roca-Ferrer, J, Bartra, J, Bulog, A, Micovic, V, Markiewicz, L, Szymkiewicz, A, Szyc, A, Wróblewska, B, Harvey, BM, Harthoorn, LF, Wesley Burks, A, Rentzos, G, Björk, A-LB, Bengtsson, U, Barber, C, Kalicinsky, C, Breynaert, C, Coorevits, L, Jansen, C, Van Hoeyveld, E, Verbeke, K, Kochuyt, A-M, Schrijvers, R, Deleanu, D, Muntean, A, Konstantakopoulou, M, Pasioti, M, Papadopoulou, A, Iliopoulou, A, Mikos, N, Kompoti, E, de Castro, ED, Bartalomé, B, Ue, KL, Griffiths, E, Till, S, Grimshaw, K, Roberts, G, Selby, A, Butiene, I, Larco, JI, Dubakiene, R, Fiandor, A, Fiocchi, A, Sigurdardottir, S, Sprikkelman, A, Schoemaker, A-F, Xepapadaki, P, Keil, T, Cojocariu, Z, Barbado, BS, Iancu, V, Arroabarren, E, Esarte, MG, Arteaga, M, Andrade, MC, Borges, D, Kalil, J, Bianchi, PG, Agondi, RC, Gupta, RK, Sharma, A, Gupta, K, Das, M, Dwivedi, P, Karseladze, R, Jorjoliani, L, Saginadze, L, Tskhakaia, M, Basello, K, Piuri, G, Speciani, AF, Speciani, MC, Camerotto, C, Zinno, F, Pakholchuk, O, Nedelska, S, Pattini, S, Costantino, MT, Peveri, S, Villalta, D, Savi, E, Costanzi, A, Revyakina, VA, Kiseleva, MA, Kuvshinova, ED, Larkova, IA, Shekhetov, AA, Silva, D, Moreira, A, Plácido, J, van der Kleij, H, van Twuijver, E, Sutorius, R, de Kam, P-J, van Odijk, J, Lindqvist, H, Lustig, E, Jácome, AAA, Aguilar, KLB, Domínguez, MG, Hernández, DAM, Caruso, C, Casale, C, Rapaccini, GL, Romano, A, De 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J, Dubois, A, de Jong, N, Matsyura, O, Besh, L, Huang, C-H, Jan, T-R, Stiefel, G, Tratt, J, Kirk, K, Arasi, S, Caminiti, L, Crisafulli, G, Fiamingo, C, Fresta, J, Pajno, G, Remington, B, Kruizinga, A, Marty Blom, W, Westerhout, J, Bijlsma, S, Blankestijn, M, Otten, H, Klemans, R, Michelsen-Huisman, AD, van Os-Medendorp, H, Kruizinga, AG, Versluis, A, van Duijn, G, de Zeeuw-Brouwer, HM-L, Castenmiller, JJM, Noteborn, HPJM, Houben, GF, Bravin, K, Luyt, D, Javed, B, Couch, P, Munro, C, Padfield, P, Sperrin, M, Byrne, A, Oosthuizen, L, Kelleher, C, Ward, F, Brosnan, N, King, G, Corbet, E, Guzmán, JAH, García, MB, Asensio, O, Navarrete, LV, Larramona, H, Miró, XD, Pyrz, K, Austin, M, Boloh, Y, Galloway, D, Hernandez, P, Hourihane, JOB, Kenna, F, Majkowska-Wojciechowska, B, Regent, L, Themisb, M, Schnadt, S, Semic-Jusufagic, A, Galvin, AD, Kauppila, T, Kuitunen, M, Kitsioulis, NA, Douladiris, N, Kostoudi, S, Manolaraki, I, Mitsias, D, Manousakis, E, Papadopoulos, NG, Knibb, R, Hammond, J, Cooke, R, Yrjänä, J, Hanni, A-M, Vähäsarja, P, Mustonen, O, Dunder, T, Kulmala, P, Lasa, E, D’Amelio, C, Martínez, S, Joral, A, Gastaminza, G, Goikoetxea, MJ, Candy, DCA, Van Ampting, MTJ, Oude Nijhuis, MM, Butt, AM, Peroni, DG, Fox, AT, Knol, J, Michaelis, LJ, Padua, I, Padrao, P, Moreira, P, Barros, R, Sharif, H, Ahmed, M, Gomaa, N, Mens, J, Smit, K, Timmermans, F, Poredoš, T, Jeverica, AK, Sedmak, M, Benedik, E, Accetto, M, Zupančič, M, Yonamine, G, Soldateli, G, Aquilante, B, Pastorino, AC, de Moraes Beck, CL, Gushken, AK, de Barros Dorna, M, dos Santos, CN, Castro, APM, Al-Qahtani, A, Arnaout, R, Khaliq, AR, Amin, R, Sheikh, F, Alvarez, J, Anda, M, Palacios, M, De Prada, M, Ponce, C, Balbino, B, Sibilano, R, Marichal, T, Gaudenzio, N, Karasuyama, H, Bruhns, P, Tsai, M, Reber, LL, Galli, SJ, Ferreira, AR, Cernadas, JR, del Campo García, A, Fernández, SP, Carrera, NS, Sánchez-Cruz, FB, Lorenzo, JRF, Claus, S, Pföhler, C, Ruëff, F, Treudler, R, Jaume, ME, Madroñero, A, Perez, MTG, Julia, JC, Plovdiv, CH, Gethings, L, Langridge, J, Adel-Patient, K, Bernard, H, Barcievic-Jones, I, Sokolova, R, Yankova, R, Ivanovska, M, Murdjeva, M, Popova, T, Dermendzhiev, S, Karjalainen, M, Lehnigk, U, Brown, D, Locklear, JC, Locklear, J, Maris, I, Hourihane, J, Ornelas, C, Caiado, J, Ferreira, MB, Pereira-Barbosa, M, Puente, Y, Daza, JC, Monteseirin, FJ, Ukleja-Sokolowska, N, Gawronska-Ukleja, E, Zbikowska-Gotz, M, Bartuzi, Z, Sokolowski, L, Adams, A, Mahon, B, English, K, Gourdon-Dubois, N, Sellam, L, Pereira, B, Michaud, E, Messaoudi, K, Evrard, B, Fauquert, J-L, Palomares, F, Gomez, G, Rodriguez, MJ, Galindo, L, Molina, A, Paparo, L, Mennini, M, Aitoro, R, Wawrzeńczyk, A, Przybyszewski, M, Sarıcoban, HE, Ugras, M, Yalvac, Z, Flokstra-de Blok, BMJ, van der Velde, JL, Vereda, A, Ippolito, C, Traversa, A, Adriano, D, Bianchi, DM, Gallina, S, Decastelli, L, Makatsori, M, Miles, A, Devetak, SP, Devetak, I, Tabet, SA, Trandbohus, JF, Winther, P, Malling, H-J, Hansen, KS, Garvey, LH, Wang, C-C, Cheng, Y-H, Tung, C-W, Dietrich, M, Marenholz, I, Kalb, B, Grosche, S, Blümchen, K, Schlags, R, Price, M, Rietz, S, Esparza-Gordillo, J, Lau, S, Lee, Y-A, Almontasheri, A, Bahkali, MA, Elshorbagi, S, Alfhaid, A, Altamimi, M, Madbouly, E, Al-Dhekri, H, Arnaout, RK, Basagaña, M, Miquel, S, Bartolomé, B, Brix, B, Rohwer, S, Brandhoff, S, Berger, A, Suer, W, Weimann, A, Bueno, C, Martín-Pedraza, L, Abián, S, Segundo-Acosta, PS, López-Rodríguez, JC, Barderas, R, Batanero, E, Cuesta-Herranz, J, Villalba, MT, Correia, M, Benito-Garcia, F, Arêde, C, Piedade, S, Morais-Almeida, M, Hindley, J, Yarham, R, Kuklinska-Pijanka, A, Gillick, D, Patient, K, Chapman, MD, Miranda, A, Matos, E, Sokolova, A, Rao, H, Baricevic-Jones, I, Smith, F, Xue, W, Magnusdottir, H, Vidarsdottir, AG, Lund, S, Jensen, AB, Ludviksson, BR, Simon, R, Elfont, R, Bennett, S, Voyksner, R, de Lurdes Torre, M, Yürek, S, Faber, MA, Bastiaensen, A, Mangodt, E, van Gasse, A, Decuyper, I, Sabato, V, Hagendorens, MM, Bridts, CH, De Clerck, LS, Ebo, D, Schwarz, S, Ziegert, M, Albroscheit, S, Schwager, C, Kull, S, Behrends, J, Röckendorf, N, Schocker, F, Frey, A, Homann, A, Becker, W-M, Jappe, U, Zaabat, N, Osscini, S, Agabriel, C, Sterling, B, Carsin, A, Liabeuf, V, Maćków, M, Zbróg, A, Bronkowska, M, Courtois, J, Gadisseur, R, Bertholet, C, Lukas, P, Cavalier, E, Delahaut, P, Quinting, B, Gertmo, MB, Hasseus, ET, Barzylovych, V, Oliveira, J, Ensina, LF, Aranda, CS, Dopazo, L, Lopez, R, Perez, R, Santos-Diez, L, Bilbao, A, Garcia, JM, Núñez, IG, Mármol, MÁA, Villarejo, MJB, Martos, JAB, Vergara, MS, García, JMI, Michalska, A, Sergiejko, G, Zacniewski, R, Ghiordanescu, I-M, Deaconu, C, Popescu, M, Bumbacea, RS, Ibranji, A, Nikolla, E, Loloci, G, Juel-Berg, N, Larsen, LF, Poulsen, LK, Marcelino, J, Prata, R, Costa, AC, Duarte, F, Neto, M, Santos, J, Pestana, LC, Sampaio, D, Minale, P, Dignetti, P, Bignardi, D, Nedelea, I, Popescu, F-D, Vieru, M, Secureanu, F-A, Ganea, CS, Vieira, M, Silva, JPM, Watts, T, Watts, S, Lomikovska, M, Peredelskaya, M, Nenasheva, N, Filipovic, I, Zivkovic, Z, Filipovic, D, Higgs, J, Warner, A, and Jones, C
- Published
- 2017
30. An analytical nonlinear morphing model for corrugated laminates.
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Kress, G. R. and Filipovic, D. T.
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- 2019
- Full Text
- View/download PDF
31. Turkey's cinvergence to the EU: Catching up or falling behind?
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Öztürk, Lütfü, Filipovic, D., Urnaut, A. G., Bursa Uludağ Üniversitesi/Sosyal Bilimler Meslek Yüksekokulu/Dış Ticaret Bölümü., Ay, Sema, and Keser, Hilal Yıldırır
- Subjects
Convergence hypothesis ,Real convergence ,Incomes ,Public administration ,Tests ,Catching up ,Australia ,Regional & urban planning ,Turkey and European union ,Economic growth - Abstract
Bu çalışma, 05 Nisan 2013 tarihleri arasında Paris[Fransa]’da düzenlenen 2. International Scientific Conference on Economic and Social Development (ESD)’da bildiri olarak sunulmuştur. In this study, convergence between Turkey and the EU has been examined by using time series econometrics in the context of per capita incomes. Firstly stochastic convergence has been summarized. Then, it has been investigated whether Turkey is catching up the EU or not. Both average incomes of the EU13 and individual income of each country in the EU13 have been considered in order to analysis Turkeys convergence process to the EU for the period 1950-2010. According to results, there have no strong convergence tendency in the income differences of Turkey EU13. Turkey is catching up only a country while falling behind of EU13 average and other twelve countries. These results indicate that Turkey must have better economic performance in the process of economic integration in order to catch up living standards of the EU. Varazdin Dev & Entrepreneurship Agcy, Fac Commercial & Business Sci Fakulteta Komercialne Poslovne Vede Schiedel Vindija
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- 2013
32. The causality relationships between FDI and R&D in European Union
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Teatar, Osman Murat, Genç, Murat Can, Değer, M. Kemal, Filipovic, D., Urnaut, A. G., Uludağ Üniversitesi/Sosyal Bilimler Meslek Yüksekokulu/Dış Ticaret Bölümü., Keser, Hilal Yıldırır, Ay, Sema, and O-6346-2016
- Subjects
Panel causality ,R&D ,Public administration ,FDI ,Foreign direct-investment ,Regional & urban planning ,European Union ,Technology imports - Abstract
Bu çalışma, 05 Nisan 2013 tarihleri arasında Paris[Fransa]’da düzenlenen 2. International Scientific Conference on Economic and Social Development (ESD)’da bildiri olarak sunulmuştur. Technological development and R&D activities are accepted as one of the factors of basic production in endogenous growth theories. There has been an increasing interest towards R&D on the level of both firm and country. Moreover countries regard FDI as an important element which increase R&D activities. Although there are numerous studies which investigate relationship of both FDI and R&D on macroeconomic variables such as economic growth, employment and export; the number of studies which investigate the relationship between FDI and R&D is quite few. The aim of this study is to analyze relationships between FDI and R&D in the example of EU15 and EU27. For this aim, 19962009 period data of mentioned countries were considered and dynamic panel causality testing was done. According to the findings obtained from empirical test made in the study, there is one-way causality relationship among EU15 and EU 27 countries from FDI towards R&D. This finding points out to the existence of complementary relationship between FDIs and R&D for EU. Varazdin Dev & Entrepreneurship Agcy, Fac Commercial & Business Sci Fakulteta Komercialne Poslovne Vede Schiedel Vindija
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- 2013
33. Transportation sector in Turkey: Future expectations about railway transportation in Turkey
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Filipovic, D., Urnaut, A. G., Uludağ Üniversitesi/Sosyal Bilimler Meslek Yüksekokulu/Dış Ticaret Bölümü., Uludağ Üniversitesi/İktisadi ve İdari Bilimler Fakültesi/Ekonometri Bölümü., Sevüktekin, Mustafa, Keser, Hilal Yıldırır, Ay, Sema, Çetin, Işın, AAG-8151-2021, and O-6346-2016
- Subjects
Public administration ,Regional & urban planning ,Transportation ,Logistics ,Railway transportation - Abstract
Bu çalışma, 5 Nisan 2013 tarihinde Paris[Fransa]'da düzenlenen 2.International Scientific Conference on Economic and Social Development (ESD)'de bildiri olarak sunulmuştur. During the economic development process, it is observed that services sector has gained importance in many importances. In the services sector, transportation is the sector that the most investment is made and the most added values are created. With various carrying types, transportation sector holds considerable share both in domestic and foreign trade with cargo transportation and in tourism and urban transportation with passenger carrying. As for the transportation sector in Turkey, in the early years of the Republic, short range railway and seaway transportation is observed to be made in the Western Anatolia. Upon the establishment of the Republic, much importance was put on railway transportation and the railway systems which would provide east-west and north-south connection were built. In early years of the 1950s, importance was started to be given in highway construction, and considerable improvement was achieved in seaport and airport construction. Overland transportation, after the years of 1950s, has been the most widely used transportation type that exhibited development due to the high cost of the substructure investments in terms of railway transportation. In recent years, Turkey has been experiencing important developments related with railway transportation. Due to playing great role of railway transportation in Turkeys effectiveness in carrying international cargo, being on an important location in the international corridor, increasing the public investments and allowances for the railway transportation, works has been started especially in terms of international cargo transportation. In this study, by examining the general structure of the transportation sector in Turkey, foresight of railway transportation until 2025 has been aimed to be made. In this frame, it is aimed to determine the role of the railway transportation in Turkeys potential economic development. Varazdin Dev & Entrepreneurship Agency Fac Commercial & Business Sci Fakulteta Komercialne Poslovne Vede Schiedel Vindija
- Published
- 2013
34. The affects of the process improvement to business performance
- Author
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Filipovic, D., Urnaut, A. G., Uludağ Üniversitesi., and Kaygusuz, Yeşim
- Subjects
Public administration ,Business performance ,Regional & urban planning ,Value analysis ,Process improvement - Abstract
Bu çalışma, 5 Nisan 2013 tarihinde Paris[Fransa]'de düzenlenen 2nd International Scientific Conference on Economic and Social Development (ESD)'de bildiri olarak sunulmuştur. The main aim of the businesses is to make profit and grow sustainably accordingly. The elements which enable companies to reach this aim are price, cost and customer satisfaction. While the price is determined in the competitive market, cost is shaped in the business processes. The customer satisfaction, on the other hand, is to what extent the output of these processes satisfied the customers. Process consists of the stages which start with taking an order from the customer and end with the delivery of the order. Should the business be likened to a chain, each link represents a process (a function). In order to improve the performance the weak link needs to be strengthen. Strengthening the weak links will only be possible by determining the halting points of the process and removing them. When the notion of the process and its improvement dealt with, the notion of value emerges. The value created in the process means cost in the output, quality and speed improvement for the company. Hence, creating values results with the customer satisfaction. Process value analysis, is the overall operations of the definition and analysis of some certain processes. It defines all the activities from production stage to its presentation to the customer, the inputs used in the operations. At the end of the analysis whether the activities in the process are necessary and if they create added value or not is considered Activity creating an added value adds value to the product the customer wanted, whereas the ones which didnt create added value cause cost and spent time to increase and do not add value to the product from customers point of view. The use of excessive amount of input, cause the costs of the product not creating added value and accordingly in the product costs to increase. The removal of these activities would provide a decrease in the expenses and strengthen the competitive situation of the company. The implementation focusing on the process and activities forming it, analyzing these methods and improvement efforts must be continuous. Continuous improvement works would return to the company in the end, as profit increase, shareholder, customer satisfaction. In this study, effects of the process improvement to the business performance will be studied. Varazdin Dev & Entrepreneurship Agcy Fac Commercial & Business Sci Fakulteta Komercialne Poslovne Vede Schiedel Vindija
- Published
- 2013
35. Effects of tillage systems on soil water content and yield in maize and winter wheat production
- Author
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Copec, K., primary, Filipovic, D., additional, Husnjak, S., additional, Kovacev, I., additional, and Kosutic, S., additional
- Published
- 2015
- Full Text
- View/download PDF
36. Critical Overview of Agency Theory
- Author
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Najla Podrug, Filipovic, D., and Milic, S.
- Subjects
Agency theory ,stewardship & organization theory - Abstract
Agency theory is an important, yet controversial, theory. This paper reviews agency theory and its contributions to organization theory. Assessment is done in comparison to stewardship theory. The intent is to clarify some of the confusions surrounding agency theory and to alert organizational scholars when using agency theory. Agency theory is confirmed as useful addition to organizational theory, but the paper offers alternative propositions based on a relaxing of agency theory’s assumptions.
- Published
- 2010
37. Design of dual-polarized millimeter wave constant eirp front-end for towed decoy platforms
- Author
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Jastram, N., primary and Filipovic, D. S., additional
- Published
- 2014
- Full Text
- View/download PDF
38. Proceedings of the Antenna Applications Symposium (32nd) Held in Monticello, Illinois on 16-18 September 2008. Volume 1
- Author
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MASSACHUSETTS UNIV AMHERST DEPT OF ELECTRICAL AND COMPUTER ENGINEERING, Elsallal, M. W., Schaubert, D. H., West, J. B., Mailloux, R. J., Santarelli, S. G., Roberts, T. M., Luu, D., Stasiowski, M., Schaubert, D., Buckley, M. J., Paulsen, L. M., Wolf, J. D., Roach, T. L., Bernhard, J. T., Filipovic, D., Potvin, G., Fontaine, D., Saito, Y., Rollin, J-M., Popovic, Z., MASSACHUSETTS UNIV AMHERST DEPT OF ELECTRICAL AND COMPUTER ENGINEERING, Elsallal, M. W., Schaubert, D. H., West, J. B., Mailloux, R. J., Santarelli, S. G., Roberts, T. M., Luu, D., Stasiowski, M., Schaubert, D., Buckley, M. J., Paulsen, L. M., Wolf, J. D., Roach, T. L., Bernhard, J. T., Filipovic, D., Potvin, G., Fontaine, D., Saito, Y., Rollin, J-M., and Popovic, Z.
- Abstract
The Proceedings of the 2008 Antenna Applications Symposium is a collection of state-of-the art papers relating to antenna arrays, millimeter wave antennas, simulation, and measurement of antennas integrated antennas and antenna bandwidth and radiation improvements., Volume 1 of 2. Volume 2, AFRL-RY-HS-TR-2008-0026-Vol-2. Volume 1 contains pages 1-269. The original document contains color images. Presented at Proceedings of the Antenna Applications Symposium (32nd) held in Monticello, Illinois on 16-18 September 2008. See also ADA494633.
- Published
- 2008
39. Proceedings of the Antenna Applications Symposium (32nd) Held in Monticello, Illinois on 16-18 September 2008. Volume 2
- Author
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MASSACHUSETTS UNIV AMHERST DEPT OF ELECTRICAL AND COMPUTER ENGINEERING, Schaubert, Daniel, Elsallal, M. W., West, J. B., Mailloux, R. J., Santarelli, S. G., Roberts, T. M., Luu, D., Stasiowski, M., Schaubert, D., Buckley, M. J., Paulsen, L. M., Wolf, J. D., Roach, T. L., Bernhard, J. T., Filipovic, D., Potvin, G., Fontaine, D., Saito, Y., Rollin, J-M., Popovic, Z., MASSACHUSETTS UNIV AMHERST DEPT OF ELECTRICAL AND COMPUTER ENGINEERING, Schaubert, Daniel, Elsallal, M. W., West, J. B., Mailloux, R. J., Santarelli, S. G., Roberts, T. M., Luu, D., Stasiowski, M., Schaubert, D., Buckley, M. J., Paulsen, L. M., Wolf, J. D., Roach, T. L., Bernhard, J. T., Filipovic, D., Potvin, G., Fontaine, D., Saito, Y., Rollin, J-M., and Popovic, Z.
- Abstract
The Proceedings of the 2007 Antenna Applications Symposium is a collection of state-of-the art papers relating to antenna arrays millimeter wave antennas simulation and measurement of antennas integrated antennas and antenna bandwidth and radiation improvements., Volume 2 of 2. Volume 1, AFRL-RY-HS-TR-2008-0026-VOL-1. Volume 2 contains pages 270-524. The original document contains color images. Presented at Proceedings of the Antenna Applications Symposium (32nd) held in Monticello, Illinois on 16-18 September 2008. See also ADA494632.
- Published
- 2008
40. Absorption effects in intermediate energy elastic electron scattering from xenon
- Author
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Cho, H., McEachran, Robert, Buckman, Stephen, Filipovic, D M, Pejcev, V, Marinkovic, B P, Tanaka, Hiroshi, Stauffer, A D, Jung, E C, Cho, H., McEachran, Robert, Buckman, Stephen, Filipovic, D M, Pejcev, V, Marinkovic, B P, Tanaka, Hiroshi, Stauffer, A D, and Jung, E C
- Abstract
We present experimental and theoretical differential cross sections for elastic electron scattering from xenon. Two independent measurements were carried out at (1) Chungnam National University for incident electron energies of 10, 20, 30, 50 and 100 eV and scattering angles from 10° up to 180° and (2) the Institute of Physics in Belgrade for incident electron energies of 20, 30 and 50 eV and scattering angles from 10° up to 150°. While these latter measurements do not cover the full angular range up to 180°, they still extend somewhat higher in scattering angle than previous measurements. It would appear that the theoretical treatment of intermediate energy elastic scattering from xenon is sensitive to the inclusion of absorption effects, particularly at backward scattering angles. This observation plus the previous results for the case of krypton indicates that the role of absorption is generally quite important for the rare gases.
- Published
- 2006
41. Low-Dispersion Spiral Antennas
- Author
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Elmansouri, M. A., primary and Filipovic, D. S., additional
- Published
- 2012
- Full Text
- View/download PDF
42. 429 The Level of Adolescent Depression Among Teens in Serbia
- Author
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Tomic, S., primary, Filipovic, I. D., additional, Filipovic, D., additional, and Ilic, M., additional
- Published
- 2012
- Full Text
- View/download PDF
43. Four-Armed Spiral-Helix Antenna
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Radway, M. J., primary and Filipovic, D. S., additional
- Published
- 2012
- Full Text
- View/download PDF
44. Mode 2 four-arm spiral antennas as pulse radiators
- Author
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Elmansouri, M. A., primary and Filipovic, D. S., additional
- Published
- 2011
- Full Text
- View/download PDF
45. C-Fos brain mapping of global and subunit-specific NMDA receptor antagonists: Relevance for their potential use as antidepressants
- Author
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Inta, D., primary, Lima, J., additional, Filipovic, D., additional, Köhr, G., additional, Sprengel, R., additional, and Gass, P., additional
- Published
- 2011
- Full Text
- View/download PDF
46. Multi-functional broadband arrays for UHF through S-band electronic warfare
- Author
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Radway, M J, primary and Filipovic, D S, additional
- Published
- 2010
- Full Text
- View/download PDF
47. Modeling and metrology of metallic nanowires with application to microwave interconnects
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Kim, K., primary, Wallis, M., additional, Rise, P., additional, Chiang, C., additional, Imtiaz, A., additional, Kabos, P., additional, and Filipovic, D. S., additional
- Published
- 2010
- Full Text
- View/download PDF
48. 57. Anxiety in the patients with rheumatoid arthritis
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Tomasevic-Todorović, S., primary, Boskovic, K., additional, Filipovic, D., additional, Naumović, N., additional, and Pantelinac, S., additional
- Published
- 2010
- Full Text
- View/download PDF
49. 56. The effect of pain on cognitive abilities of patients with rheumatoid arthritis
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Tomasevic-Todorović, S., primary, Filipovic, D., additional, and Boskovic, K., additional
- Published
- 2010
- Full Text
- View/download PDF
50. Controlling the regiospecificity and coupling of cytochrome P450cam: T185F mutant increases coupling and abolishes 3-hydroxynorcamphor product
- Author
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Paulsen, M. D., Filipovic, D., Sligar, S. G., and Ornstein, R. L.
- Subjects
Binding Sites ,Camphor 5-Monooxygenase ,Cytochrome P-450 Enzyme System ,Models, Chemical ,Escherichia coli ,Mutagenesis, Site-Directed ,Computer Simulation ,Hydroxylation ,Protein Engineering ,Norbornanes ,Research Article ,Mixed Function Oxygenases ,Substrate Specificity - Abstract
Cytochrome P450cam (P450CIA1) catalyzes the hydroxylation of camphor and several substrate analogues such as norcamphor and 1-methyl-norcamphor. Hydroxylation was found experimentally at the 3, 5, and 6 positions of norcamphor, but only at the 5 and 6 positions of 1-methyl-norcamphor. In the catalytic cycle, the hydroxylation of substrate is coupled to the consumption of NADH. For camphor, the degree of coupling is 100%, but for both norcamphor and 1-methyl-norcamphor, the efficiency is dramatically lowered to 12% and 50%, respectively. Based on an examination of the active site of P450cam, it appeared that mutating position 185 might dramatically alter the product specificity and coupling of hydroxylation of norcamphor by P450cam. Analysis of molecular dynamics trajectories of norcamphor bound to the T185F mutant of cytochrome P450cam predicted that hydroxylation at the 3 position should be abolished and that the coupling should be dramatically increased. This mutant was constructed and the product profile and coupling experimentally determined. The coupling was doubled, and hydroxylation at the 3 position was essentially abolished. Both of these results are in agreement with the prediction.
- Published
- 1993
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