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5 results on '"Filipovič, Tatjana"'

3. Vnetni profil v krvi pri bolnikih po epileptičnem napadu

Author

Filipovič, Tatjana and Vodušek, David B.

Subjects
magnetnoresonančna angiografija, encefalitis, napadi, neurology, magnetic resonance angiography, encephalitis, krvnomožganska pregrada, blood-brain barrier, cytokines, udc:616.853(043.3), epilepsija, citokini, epilepsy, nevrologija, seizures
Published
2018

4. Critical illness myopathy in patients with central nervous system disorders: Miopatija kritične bolezni pri bolnikih z okvaro osrednjega živčevja

Author

Filipovič, Tatjana, Meznarič, Marija, Rodi, Zoran, Švigelj, Viktor, and Zidar, Janez

Abstract

Background Acute myopathy or neuropathy is a common complication in criticallyill patients in intensive care unit. This complication is relativelyobvious in patients with primary non-neurological disorder. However,such complication is difficult to notice in patients with primary neurological disorder. The aim of our report is to present four patients with a primary central nervous disease who subsequently developed a secondary peripheral nervous disorder. Patients and The four patients had been admitted to the intensive care unit of the Neurological Demethods partment for the acute cerebral disorder. Additionally in the course of disease they had developed clinical signs of either neuropathy or myopathy. One patient was unable to wean from the ventilator. Electrodiagnostic studies and muscle biopsy were performed. Results Electrodiagnostic studies revealed generalized abnormalities, consistent with both neuropathy and myopathy. The predominant finding in muscle biopsy was a myopathy with moderate to severe myosin filament loss. Conclusions This report brings two messages. The first is that one should be aware of the possibility of critical illness myopathy/neuropathyalso in the neurological intensive care unit. As this peripheral neurological complication is superimposed on primary central neurological disorder, it may be more difficult to notice and to diagnose it clinically. The second message is that electrodiagnostic studies, though mandatory in confirming peripheral lesion, often cannot distinguish between myopathy and neuropathy. As myopathy bears substantially favorable prognosis, a muscle biopsy may be recommended in such cases.

Published
2009

5. Oblici akumulacije lipofuscina u ganglijskim ćelijama gornjeg vratnog gangliona kod čoveka.

Author

Živkovič, Vladimir, Stefanovič, Natalija, Đurovič-Filipovič, Tatjana, Pavlovič, Snežana, Stojanovič, Vesna, Bakič, Mirjana, Kundalič, Braca, and Pavlovič, Miljana

Subjects
*LIPOFUSCINS, *NEURONS, *MITOSIS, *CELLULAR aging, *EOSIN, *HISTOLOGICAL techniques
Abstract

Background/Aim. Considering available literature lipofuscin is a classical age pigment of postmitotic cells, and a consistently recognized phenomenon in humans and animals. Lipofuscin accumulation is characteristic for nerve cells that are postmitotic. This research was focused on lipofuscin accumulation in ganglionic cells (GC) (postganglionic sympathetic cell bodies) of superior cervical ganglion in humans during ageing. Methods. We analysed 30 ganglions from cadavers ranging from 20 to over 80 years of age. As material the tissue samples were used from the middle portion of the ganglion, which was separated from the surrounding tissue by the method of macrodissection. The tissue samples were routinely fixed in 10% neutral formalin and embedded in paraffin for classical histological analysis, then three consecutive (successive) sections 5 µm thick were made and stained with hematoxylin and eosin method (HE), silver impregnation technique by Masson Fontana and trichrome stain by Florantin. Results. Immersion microscopy was used to analyse patterns of lipofuscin accumulation during ageing making possible to distinguish diffuse type (lipofuscin granules were irregularly distributed and non-confluent), unipolar type (lipofuscin granules were grouped at the end of the cell), bipolar type (lipofuscin granules were concentrated at the two opposite ends of a cell with the nucleus in between at the center of a cell), annular type (lipofuscin granules were in the shape of a complete or incomplete ring around the nucleus) and a cell completely filled with lipofuscin (two subtypes distinguishing, one with visible a nucleus, and the other with invisible one). Even at the age of 20 there were cells with lipofuscin granules accumulated in diffuse way, but in smaller numbers; the GC without lipofuscin were dominant. Growing older, especially above 60 years, all of the above mentioned patterns of lipofuscin accumulation were present with the evident increase in cells completely filled with lipofuscin, but cells without lipofuscin were also present even in the oldest persons. Conclusion. Lipofuscin is present in all periods of ageing with a different intensity of accumulation. GC without the pigment, diffusely distributed, as well as very rare cells with a unipolar type of lipofuscin distribution are characteristic for the age of 20-60 years. In the age above 60 years, except the cells without pigment and diffuse accumulation type, there are also bipolar and annular types and forms in which cells are completely filled with lipofuscin granules. [ABSTRACT FROM AUTHOR]

Published
2008

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