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19 results on '"Filipova, Jana"'

2. Short Time Series of Website Visits Prediction by RBF Neural Networks and Support Vector Machine Regression

Author

Olej, Vladimir, Filipova, Jana, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Rutkowski, Leszek, editor, Korytkowski, Marcin, editor, Scherer, Rafał, editor, Tadeusiewicz, Ryszard, editor, Zadeh, Lotfi A., editor, and Zurada, Jacek M., editor

Published
2012
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5. Mutation landscape of multiple myeloma measurable residual disease: identification of targets for precision medicine

Author

Zátopková, Martina, Ševčíková, Tereza, Fanfani, Viola, Chyra, Zuzana, Říhová, Lucie, Bezděková, Renata, Žihala, David, Growková, Kateřina, Filipová, Jana, Černá, Lucie, Broskevičova, Lucie, Kryukov, Fedor, Minařík, Jiří, Smejkalová, Jana, Maisnar, Vladimír, Harvanová, Ĺubica, Pour, Luděk, Jungova, Alexandra, Popková, Tereza, Bago, Juli Rodriguez, Anilkumar Sithara, Anjana, Hrdinka, Matouš, Jelínek, Tomáš, Šimíček, Michal, Stracquadanio, Giovanni, and Hájek, Roman

Published
2022
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7. Whole Exome Sequencing of Residual Disease in Multiple Myeloma: Searching for Novel Therapeutic Targets

Author

Zátopková, Martina, primary, Sevcikova, Tereza, additional, Kufova, Zuzana, additional, Growkova, Katerina, additional, Filipova, Jana, additional, Jelinek, Tomas, additional, Říhová, Lucie, additional, Bezděková, Renata, additional, Kryukov, Fedor, additional, Smejkalová, Jana, additional, Minarik, Jiri, additional, Maisnar, Vladimir, additional, Mistrik, Martin, additional, Pour, Ludek, additional, Jungova, Alexandra, additional, Šimíček, Michal, additional, Stracquadanio, Giovanni, additional, and Hajek, Roman, additional

Published
2018
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10. Novel Approach to Study Relationship Between Copy Number Variation and Gene Expression in Multiple Myeloma

Author

Brozova, Lucie, primary, Kryukov, Fedor, additional, Filipova, Jana, additional, Sevcikova, Tereza, additional, Kufova, Zuzana, additional, Growkova, Katerina, additional, Kryukova, Elena, additional, Smetana, Jan, additional, Nemec, Pavel, additional, Jarkovsky, Jiri, additional, Hajek, Roman, additional, and Simicek, Michal, additional

Published
2017
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18. Whole Exome Sequencing of Plasma Cells Precancerosis MGUS and Malignant AL Amyloidosis Reveals Small Number of Shared Mutated Genes

Author

Kufova, Zuzana, Growkova, Katerina, Vojta, Petr, Filipova, Jana, Simicek, Michal, Jelinek, Tomas, Zatopkova, Martina, Grosicki, Sebastian, Mikulasova, Aneta, Hajduch, Marian, Pour, Ludek, Stork, Martin, Sevcikova, Tereza, and Hajek, Roman

Abstract

Background:Immunoglobulin light chain amyloidosis (ALA) is a plasma cell dyscrasia that develops, similarly as multiple myeloma (MM), from clinically indistinguishable precancerous stage, monoclonal gammopathy of undetermined significance (MGUS). The specific mutations causing malignant transformation from MGUS to amyloidogenic immunoglobulin producing ALA are still unknown. The next generation sequencing (NGS) technology is a powerful tool that allows comprehensive description of the whole genome sequence. Previous studies have already shown highly overlapping phenotypic profile between ALA and both MGUS and MM and lack of unifying mutations in ALA patients (Paiva, 2016). Here we present whole exome NGS data of aberrant plasma cells (aPCs) obtained from patients with MGUS (n=10) and ALA (n=9). Further comparison of the exome sequences of the precancerosis and malignant stage will help to identify recurrently occurring mutations, novel oncogenic drivers and tumor suppressor genes. This will offer new prognostic markers to distinguish potential malignant plasma cell clones in MGUS that will ultimately lead to the development of fatal ALA.

Published
2017
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19. Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis.

Author

Chyra Z, Sevcikova T, Vojta P, Puterova J, Brozova L, Growkova K, Filipova J, Zatopkova M, Grosicki S, Barchnicka A, Jedrzejczak WW, Waszczuk-Gajda A, Jungova A, Mikulasova A, Hajduch M, Mokrejs M, Pour L, Stork M, Harvanova L, Mistrik M, Mikala G, Robak P, Czyz A, Debski J, Usnarska-Zubkiewicz L, Jurczyszyn A, Stejskal L, Morgan G, Kryukov F, Budinska E, Simicek M, Jelinek T, Hrdinka M, and Hajek R

Subjects
Humans, Immunoglobulin Light Chains genetics, Mutation, Pathology, Molecular, Plasma Cells, Amyloidosis diagnosis, Amyloidosis genetics, Immunoglobulin Light-chain Amyloidosis diagnosis, Immunoglobulin Light-chain Amyloidosis genetics
Published
2021
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