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Your search keyword '"Filipczak, Piotr T."' showing total 14 results
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14 results on '"Filipczak, Piotr T."'

2. Supplementary Methods, Tables S1 - S4, Figure S1 from Dietary Nutrient Intake, Ethnicity, and Epigenetic Silencing of Lung Cancer Genes Detected in Sputum in New Mexican Smokers

Author

Leng, Shuguang, primary, Picchi, Maria A., primary, Kang, Huining, primary, Wu, Guodong, primary, Filipczak, Piotr T., primary, Juri, Daniel E., primary, Zhang, Xiequn, primary, Gauderman, W. James, primary, Gilliland, Frank D., primary, and Belinsky, Steven A., primary

Published
2023
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10. Gestational Exposure to Sidestream (Secondhand) Cigarette Smoke Promotes Transgenerational Epigenetic Transmission of Exacerbated Allergic Asthma and Bronchopulmonary Dysplasia

Author

Singh, Shashi P., primary, Chand, Hitendra S., additional, Langley, Raymond J., additional, Mishra, Neerad, additional, Barrett, Ted, additional, Rudolph, Karin, additional, Tellez, Carmen, additional, Filipczak, Piotr T., additional, Belinsky, Steve, additional, Saeed, Ali I., additional, Sheybani, Aryaz, additional, Exil, Vernat, additional, Agarwal, Hemant, additional, Sidhaye, Venkataramana K., additional, Sussan, Thomas, additional, Biswal, Shyam, additional, and Sopori, Mohan, additional

Published
2017
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14. Magnetic resonance imaging provides sensitive in vivo assessment of experimental ventilator-induced lung injury.

Author

Kuethe DO, Filipczak PT, Hix JM, Gigliotti AP, Estépar RS, Washko GR, Baron RM, and Fredenburgh LE

Subjects
Airway Resistance, Animals, Lipopolysaccharides pharmacology, Lung diagnostic imaging, Lung immunology, Lung physiopathology, Magnetic Resonance Imaging, Male, Neutrophil Infiltration, Rats, Sprague-Dawley, Respiration, Artificial, Ventilator-Induced Lung Injury immunology, Ventilator-Induced Lung Injury physiopathology, Ventilator-Induced Lung Injury diagnostic imaging
Abstract

Animal models play a critical role in the study of acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI). One limitation has been the lack of a suitable method for serial assessment of acute lung injury (ALI) in vivo. In this study, we demonstrate the sensitivity of magnetic resonance imaging (MRI) to assess ALI in real time in rat models of VILI. Sprague-Dawley rats were untreated or treated with intratracheal lipopolysaccharide or PBS. After 48 h, animals were mechanically ventilated for up to 15 h to induce VILI. Free induction decay (FID)-projection images were made hourly. Image data were collected continuously for 30 min and divided into 13 phases of the ventilatory cycle to make cinematic images. Interleaved measurements of respiratory mechanics were performed using a flexiVent ventilator. The degree of lung infiltration was quantified in serial images throughout the progression or resolution of VILI. MRI detected VILI significantly earlier (3.8 ± 1.6 h) than it was detected by altered lung mechanics (9.5 ± 3.9 h, P = 0.0156). Animals with VILI had a significant increase in the Index of Infiltration (P = 0.0027), and early regional lung infiltrates detected by MRI correlated with edema and inflammatory lung injury on histopathology. We were also able to visualize and quantify regression of VILI in real time upon institution of protective mechanical ventilation. Magnetic resonance lung imaging can be utilized to investigate mechanisms underlying the development and propagation of ALI, and to test the therapeutic effects of new treatments and ventilator strategies on the resolution of ALI., (Copyright © 2016 the American Physiological Society.)

Published
2016
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