Search

Your search keyword '"Filip, Rafal"' showing total 40 results
Start Over Author "Filip, Rafal"
40 results on '"Filip, Rafal"'

1. Efficacy and safety of 48 weeks of guselkumab for patients with Crohn's disease: maintenance results from the phase 2, randomised, double-blind GALAXI-1 trial

Author

Oliinyk, Oleksandr, Bilianskyi, Leonid, Gniady-Jastrzebska, Jadwiga, Petryka, Robert, Arlukowicz, Tomasz, Gietka, Piotr, Zmudzinski, Marcin, Mumtaz, Syed, Wolf, Douglas, Wojcik, Katarzyna, Duvall, George, Augustyn, Monika, Filip, Rafal, Tarabar, Dino, Tkachev, Alexander, Seidler, Ursula, Zittan, Eran, Pokrotnieks, Juris, Shchukina, Oksana, Machavariani, Andro, Loy, Laura, Abu-farsakh, Niazy, Marina, Pesegova, Sreckovic, Slobodan, Laclav, Martin, Wei, Shu-Chen, Suiter, Daniel, Borsuk, Aleksey, Hebuterne, Xavier, Buning, Carsten, Lahat-Zok, Adi, Danilkiewicz, Wit, Frysna, Bernadetta, Jovicic, Ivana, Datsenko, Olena, Guram, Maninder, Jain, Animesh, Rashid, Zahid, Heeren, Sonja, Shulga, Natallia, Timkin, Ivan, Gornjakovic, Srdjan, Lukas, Milan, Altwegg, Romain, Desjeux, Ariadne, Reimund, Jean-Marie, Giorgadze, Manana, Jochum, Christoph, Ito, Hiroaki, Nakai, Katsuhiko, Takagi, Tomohisa, Zaha, Osamu, Choi, Changhwan, Kim, Taeoh, Lee, Jonghun, Stundiene, Ieva, Hilmi, Ida Normiha, Hj Md Said, Rosaida, Leszczyszyn, Jaroslaw, Abdulganieva, Diana, Fominykh, Yulia, Maksyashina, Svetlana, Balaz, Jozef, Van Domselaar, Manuel, Kav, Taylan, Dennis, Patrick, Henry, Patricia, Holmes, Robert, Johnson, Christopher, McBride, Matthew, Sarles, Harry, Moore, Gregory, Yakubtsevich, Ruslan, Muls, Vinciane, Trbojevic, Stevan, Afif, Waqqas, Bernstein, Charles, Klarin, Ivo, Serclova, Zuzana, Volfova, Miroslava, Desreumaux, Pierre, Gilletta de Saint Joseph, Cyrielle, Roblin, Xavier, Vuitton, Lucine, Chelidze, Kakhaber, Kuehbacher, Tanja, Koutroubakis, Ioannis, Cicala, Michele, Fries, Walter, Gasbarrini, Antonio, Aoyama, Nobuo, Hayashi, Yoshito, Hirai, Fumihito, Horiki, Norkiyuki, Hoshi, Namiko, Inaba, Tomoki, Hiroyasu, Ishida, Maemoto, Atsuo, Matsumoto, Takayuki, Matsushima, Kayoko, Motoya, Satoshi, Taruishi, Masaki, Rashid, Mohammed, Chun, Jaeyoung, Kim, Young-Ho, Park, Dong Il, Sharara, Ala, Jonaitis, Laimas, Deriban, Gjorgi, Brooker, James, Gawdis-Wojnarska, Beata, Wozniak-Stolarska, Barbara, Andreev, Pavel, Simanenkov, Vladimir, Trofimov, Vasiliy, Jovanovic, Igor, Zdravkovic, Natasa, Aldeguer i Mante, Xavier, Hernandez Ramirez, Vicent, Akpinar, Hale, Celebi, Gurkan, Hamzaoglu, Hulya, Fernandez, Juan, Kamath, Jayaprakash, Palekar, Nicole, Pruthi, Jatinder S., Rausher, David, Ritter, Timothy, Danese, Silvio, Panaccione, Remo, Feagan, Brian G, Afzali, Anita, Rubin, David T, Sands, Bruce E, Reinisch, Walter, Panés, Julián, Sahoo, Aparna, Terry, Natalie A, Chan, Daphne, Han, Chenglong, Frustaci, Mary Ellen, Yang, Zijiang, Sandborn, William J, Hisamatsu, Tadakazu, Andrews, Jane M, and D'Haens, Geert R

Published
2024
Full Text
View/download PDF

2. Guselkumab in Patients With Moderately to Severely Active Ulcerative Colitis: QUASAR Phase 2b Induction Study

Author

Abrahamovych, Orest, Afanasieva, Halyna, Aitova, Lilia, Altintas, Engin, Altwegg, Romain, Andreev, Pavel, Aomatsu, Kazuki, Augustyn, Monika, Balestrieri, Paola, Begun, Jakob, Brunatto, Luciana, Bulgheroni, Diego, Bunkova, Elena, Cabello, Mercedes, Cao, Qian, Caprioli, Flavio, Cerqueira, Rute, Chen, Baili, Chen, Chou-Chen, Chen, Chou-Pin, Chiu, Cheng-Tang, Choi, Chang Hwan, Cicala, Michele, Datsenko, Olena, Dewint, Pieter, Domenech, Eugeni, Dutré, Joris, Duvall, George, Fernandez, Juan, Filip, Rafal, Fogel, Ronald, Fowler, Sharyle, Fujii, Toshimitsu, Fukata, Masayuki, Furumoto, Yohei, Gasbarrini, Antonio, Gawdis-Wojnarska, Beata, Gilletta, Cyrielle, Gionchetti, Paolo, Goldin, Eran, Golovchenko, Oleksandr, Gonciarz, Maciej, Gonen, Can, Segura, Gaston Gonzalez, Gridnyev, Oleksii, Gyokeres, Tibor, Hébuterne, Xavier, Hedin, Charlotte, Hellström, Per, Hilmi, Ida Normiha, Horný, Ivo, Horvat, Gyula, Hoshi, Namiko, Hrdlicka, Ludek, Ishihara, Shunji, Ivanishyn, Olha, Jang, Byung Ik, Junior, Odery, Kagaya, Takashi, Kanmura, Shuji, Karakina, Marina, Katsuhiko, Nakai, Kierkus, Jaroslaw, Kim, Hyo Jong, Kim, Tae-Oh, Kim, Young-Ho, Kiss, Gyula G., Klaus, Jochen, Kleczkowski, Dariusz, Klopocka, Maria, Kobayashi, Taku, Kobielusz-Gembala, Iwona, Koo, Ja Seol, Kopon, Adam, Kravchenko, Tetiana, Kudo, Masatoshi, Kwon, Kwang An, Lago, Paula, Laharie, David, Lawrance, Ian, Leszczyszyn, Jaroslaw, Li, Yan, Lukas, Milan, Maaser, Christian, Maemoto, Atsuo, Marusawa, Hiroyuki, McBride, Matthew, Mendu, Shoba, Miheller, Pal, Miyabayashi, Hideharu, Mohl, Wolfgang, Moore, Gregory, Motoya, Satoshi, Murali, Narayanachar, Naem, Mohammed, Nakajima, Koichi, Nakamoto, Yasunari, Nancey, Stéphane, Neto, Joaquim, Onizawa, Michio, Ono, Yohei, Osada, Taro, Osipenko, Marina, Owczarek, Danuta, Patel, Bhaktasharan, Patel, Kamal, Petrova, Elina, Poroshina, Elena, Portela, Francisco, Prystupa, Lyudmyla, Rivero, Monserrat, Roblin, Xavier, Romatowski, Jacek, Rydzewska, Grazyna, Saibeni, Simone, Sakuraba, Hirotake, Samaan, Mark, Schultz, Michael, Schulze, Joerg, Sedghi, Shahriar, Seidler, Ursula, Shin, Sung Jae, Stanislavchuk, Mykola, Stokesberry, David, Suzuki, Takayoshi, Taguchi, Hiroki, Tankova, Lyudmila, Thin, Lena, Tkachev, Alexander, Torrealba, Leyanira, Tsarynna, Nataliia, Tulassay, Zsolt, Ueo, Tetsuya, Valuyskikh, Ekaterina, Vasilevskaya, Olga, Viamonte, Manuel, Wei, Shu-Chen, Weisshof, Roni, Wojcik, Katarzyna, Ye, Byong Duk, Yen, Hsu-Heng, Yoon, Hyuk, Yoshida, Kosuke, Yurkiv, Andriy, Zaha, Osamu, Zhan, Qiang, Peyrin-Biroulet, Laurent, Allegretti, Jessica R., Rubin, David T., Bressler, Brian, Germinaro, Matthew, Huang, Kuan-Hsiang (Gary), Shipitofsky, Nicole, Zhang, Hongyan, Wilson, Rebbecca, Han, Chenglong, Feagan, Brian G., Sandborn, William J., Panés, Julian, Hisamatsu, Tadakazu, Lichtenstein, Gary R., Sands, Bruce E., and Dignass, Axel

Published
2023
Full Text
View/download PDF

3. Ustekinumab versus adalimumab for induction and maintenance therapy in biologic-naive patients with moderately to severely active Crohn's disease: a multicentre, randomised, double-blind, parallel-group, phase 3b trial

Author

Afzali, Anita, Aitova, Lilia, Aldeguer i Mante, Xavier, Allez, Matthieu, Altorjay, István, Argüelles Arias, Federico, Armuzzi, Alessandro, Augustyn, Monika, Bafutto, Mauro, Barrio, Jesus, Begun, Jakob, Behrend, Clint, Bezemer, Geert, Bonnaud, Guillaume, Brankovic, Marija, Byung, Ik Jang, Calvet Calvo, Xavier, Chachu, Karen, Chebli, Julio Maria Fonseca, Cheon, Jae Hee, Cichoz-Lach, Halina, Clark, Larry, Cummings, Fraser, Dalal, Kunal, Danese, Silvio, De Boer, Nanne, De Lourdes Ferrari, Maria, Désilets, Etienne, Dugalic, Predrag, Duvall, George, Fedorishina, Olga, Filip, Rafal, Flores, Cristina, Fogel, Ronald, Fon, James, Frankel, Michael, Friedenberg, Keith, Fries, Walter, Galina, Vassileva, Gietka, Piotr, Goel, Rishi, Hasselblatt, Peter, Herfarth, Hans, Herszényi, László, Hindryckx, Pieter, Hoentjen, Frank, Horjus Talabur Horje, Carmen, Iduru, Satish, Irving, Peter, Isfort, Robert, Jairath, Vipul, Jones, Michael, Kalimullina, Dilara, Katz, Jeffry, Kaur, Manreet, Khurana, Sunil K, Kim, Joo Sung, Kim, Youngho, Kleczkowski, Dariusz, Knezevic, Slavko, Knoll, Aaron, Korman, Louis Y, Kotzev, Iskren, Kulyapin, Andrey, Lee, Kang Moon, Leemreis, Desiree, Leszczyszyn, Jaroslaw, Limdi, Jimmy, Lissauer, Jack, Loftus, Edward, Malecka-Panas, Ewa, Marshall, John, Mihály, Emese, Milan, Lukas, Monteleone, Giovanni, Nagorni, Aleksandar, Owczarek, Danuta, Palekar, Nichole, Panaccione, Remo, Park, Young Soo, Park, Sang Hyoung, Parra, Rogério, Patai, Árpád, Patel, Kamal, Patel, Bhaktasharan, Pershko, Anatoly, Petrova, Elina, Pineton de Chambrun, Guillaume, Randall, Charles, Riestra Menendez, Sabino, Ritter, Timothy, Rivero, Montserrat, Roblin, Xavier, Rocca, Rodolfo, Romatowski, Jacek, Rydzewska, Grazyna, Saibeni, Simone, Salzberg, Bruce, Sarles, Harry, Saunders, John, Savarino, Edoardo Vincenzo, Serclova, Zuzana, Shchukina, Oksana, Siegel, Jonathan, Soofi, Najm, Sparrow, Miles, Stokesberry, David, Suiter, Daniel, Svorcan, Petar, Tkachev, Alexander, Tsonev, Nikolay, Tünde, Kristóf, Ulbrych, Jan, Vanasek, Tomas, Varga, Márta, Vermeire, Severine, Vicente Lidon, Raquel, Weiss, Michael L, Wesley, Emma, Winstead, Nathaniel, Wojcik, Katarzyna, Wypych, Joanna, Zaltman, Cyrla, Zdena, Zadorova, Sands, Bruce E, Irving, Peter M, Hoops, Timothy, Izanec, James L, Gao, Long-Long, Gasink, Christopher, Greenspan, Andrew, Hanauer, Stephen B, Kuehbacher, Tanja, Lewis, James D, Loftus, Edward V, Jr, Mihaly, Emese, Scherl, Ellen, Shchukina, Oksana B, and Sandborn, William J

Published
2022
Full Text
View/download PDF

4. Efficacy and safety of 48 weeks of guselkumab for patients with Crohn's disease: maintenance results from the phase 2, randomised, double-blind GALAXI-1 trial

Author

Danese, Silvio, primary, Panaccione, Remo, additional, Feagan, Brian G, additional, Afzali, Anita, additional, Rubin, David T, additional, Sands, Bruce E, additional, Reinisch, Walter, additional, Panés, Julián, additional, Sahoo, Aparna, additional, Terry, Natalie A, additional, Chan, Daphne, additional, Han, Chenglong, additional, Frustaci, Mary Ellen, additional, Yang, Zijiang, additional, Sandborn, William J, additional, Hisamatsu, Tadakazu, additional, Andrews, Jane M, additional, D'Haens, Geert R, additional, Oliinyk, Oleksandr, additional, Bilianskyi, Leonid, additional, Gniady-Jastrzebska, Jadwiga, additional, Petryka, Robert, additional, Arlukowicz, Tomasz, additional, Gietka, Piotr, additional, Zmudzinski, Marcin, additional, Mumtaz, Syed, additional, Wolf, Douglas, additional, Wojcik, Katarzyna, additional, Duvall, George, additional, Augustyn, Monika, additional, Filip, Rafal, additional, Tarabar, Dino, additional, Tkachev, Alexander, additional, Seidler, Ursula, additional, Zittan, Eran, additional, Pokrotnieks, Juris, additional, Shchukina, Oksana, additional, Machavariani, Andro, additional, Loy, Laura, additional, Abu-farsakh, Niazy, additional, Marina, Pesegova, additional, Sreckovic, Slobodan, additional, Laclav, Martin, additional, Wei, Shu-Chen, additional, Suiter, Daniel, additional, Borsuk, Aleksey, additional, Hebuterne, Xavier, additional, Buning, Carsten, additional, Lahat-Zok, Adi, additional, Danilkiewicz, Wit, additional, Frysna, Bernadetta, additional, Jovicic, Ivana, additional, Datsenko, Olena, additional, Guram, Maninder, additional, Jain, Animesh, additional, Rashid, Zahid, additional, Heeren, Sonja, additional, Shulga, Natallia, additional, Timkin, Ivan, additional, Gornjakovic, Srdjan, additional, Lukas, Milan, additional, Altwegg, Romain, additional, Desjeux, Ariadne, additional, Reimund, Jean-Marie, additional, Giorgadze, Manana, additional, Jochum, Christoph, additional, Ito, Hiroaki, additional, Nakai, Katsuhiko, additional, Takagi, Tomohisa, additional, Zaha, Osamu, additional, Choi, Changhwan, additional, Kim, Taeoh, additional, Lee, Jonghun, additional, Stundiene, Ieva, additional, Hilmi, Ida Normiha, additional, Hj Md Said, Rosaida, additional, Leszczyszyn, Jaroslaw, additional, Abdulganieva, Diana, additional, Fominykh, Yulia, additional, Maksyashina, Svetlana, additional, Balaz, Jozef, additional, Van Domselaar, Manuel, additional, Kav, Taylan, additional, Dennis, Patrick, additional, Henry, Patricia, additional, Holmes, Robert, additional, Johnson, Christopher, additional, McBride, Matthew, additional, Sarles, Harry, additional, Moore, Gregory, additional, Yakubtsevich, Ruslan, additional, Muls, Vinciane, additional, Trbojevic, Stevan, additional, Afif, Waqqas, additional, Bernstein, Charles, additional, Klarin, Ivo, additional, Serclova, Zuzana, additional, Volfova, Miroslava, additional, Desreumaux, Pierre, additional, Gilletta de Saint Joseph, Cyrielle, additional, Roblin, Xavier, additional, Vuitton, Lucine, additional, Chelidze, Kakhaber, additional, Kuehbacher, Tanja, additional, Koutroubakis, Ioannis, additional, Cicala, Michele, additional, Fries, Walter, additional, Gasbarrini, Antonio, additional, Aoyama, Nobuo, additional, Hayashi, Yoshito, additional, Hirai, Fumihito, additional, Horiki, Norkiyuki, additional, Hoshi, Namiko, additional, Inaba, Tomoki, additional, Hiroyasu, Ishida, additional, Maemoto, Atsuo, additional, Matsumoto, Takayuki, additional, Matsushima, Kayoko, additional, Motoya, Satoshi, additional, Taruishi, Masaki, additional, Rashid, Mohammed, additional, Chun, Jaeyoung, additional, Kim, Young-Ho, additional, Park, Dong Il, additional, Sharara, Ala, additional, Jonaitis, Laimas, additional, Deriban, Gjorgi, additional, Brooker, James, additional, Gawdis-Wojnarska, Beata, additional, Wozniak-Stolarska, Barbara, additional, Andreev, Pavel, additional, Simanenkov, Vladimir, additional, Trofimov, Vasiliy, additional, Jovanovic, Igor, additional, Zdravkovic, Natasa, additional, Aldeguer i Mante, Xavier, additional, Hernandez Ramirez, Vicent, additional, Akpinar, Hale, additional, Celebi, Gurkan, additional, Hamzaoglu, Hulya, additional, Fernandez, Juan, additional, Kamath, Jayaprakash, additional, Palekar, Nicole, additional, Pruthi, Jatinder S., additional, Rausher, David, additional, and Ritter, Timothy, additional

Published
2024
Full Text
View/download PDF

5. Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study

Author

Mautalén, Carlos Alfredo, Man, Zulema, Zanchetta, Jose Ruben, Magaril, Clelia Haydee, Sambrook, Philip, Reginster, Jean-Yves, Geusens, Piet, Goemaere, Stefan, Albergaria, Ben Hur, Zerbini, Cristiano Augusto de Freitas, Castro, Marise Lazaretti, Gregorio, Luiz Henrique, Stoilov, Rumen, Borissova, Anna-Maria I, Hristozov, Kiril Hristov, Temelkova, Nataliya L, Daskalova, Ivona Kirilova, Kuzmanova, Stefka Ivanova, Yaneva-Bichovska, Daniela, Batalov, Anastas Zgurov, Riedemann, Pablo, Rodriguez Portales, José Adolfo, Tang, Hai, Zhu, hanmin, Zhang, Zhenlin, Chao, Aijun, Hu, Yali, Liu, Zhiming, Lu, Juming, Qiu, Mingcai, Gao, Xin, Zhang, Shaofen, Xu, Ling, Xia, Weibo, Liao, Eryuan, Yang, Wenying, Wu, Wen, Dai, Kerong, Hu, Renming, Jaller, Juan Jose, Cabal, Francisco, Molina, José Fernando, Cure Cure, Carlos A, Yupanqui-Lozno, Hernan, Chalem, Philippe, Londono, John, Abello, Mauricio, Tobias, Edgardo D, Otero, William, Nikolic, Tatjana, Miskic, Blazenka, Stepan, Jan, Vyskocil, Vaclav, Novosad, Libor, Slesinger, Jan, Novosad, Pavel, Vlckova, Erika, Bortlik, Ladislav, Dokoupilova, Eva, Hala, Tomas, Jensen, Jens-Erik Beck, Brixen, Kim Torsten, Langdahl, Bente Lomholt, Schwarz, Peter, Eskildsen, Peter Claes, Eiken, Pia Agnete, Hermann, Anne Pernille, Gram, Jeppe, Schou, Maiken Brix, Alexandersen, Peter, Nedergaard, Bettina, Mejía, Dolores Magdalena, Estrella De Henriquez, Lourdes, Páez, Norka, Velazco, Casimiro, Valter, Ivo, Vahula, Kadri-Liina, Kull, Ingrid, Maasalu, Katre, Chapurlat, Roland, Fardellone, Patrice, Benhamou, Claude Laurent, Roux, Christian, Weryha, Georges, Herkt, Volkmar, Martz, Rene, Nischik, Ruth, Spieler, Wolfgang, Contzen, Christel, Felsenberg, Dieter, Frieling, Isolde, Frahm, Eike, Briones, Henry, Sandoval, Boris, Barrios, Patricia, García, Abraham, Avendaño, Carlos, González, Magdalena, Guerra, Jeremías, Tuna, Maria, Díaz, Olga Marina, Samayoa, Eduardo, López, Edgar, Barrera, José Raúl, Palencia, Mainor, Cifuentes, Mayra, Alvarado, Georgina, López, Miriam, Chavez, Nilmo, Haase, Franklin, Rivera, Ruddy, González, Claudio, Tan, Kathryn, Leung, Ping Chung, Mandalam, Sheshadri, Pitale, Shailesh Umakant, Bantwal, Ganapathi, Ammini, Ariachery Chinamma, Shaikh, Shehla Sajid Akhta, Kanakatte Mylariah, Prasanna Kumar, Dharmalingam, Mala, Mukhopadhyay, Satinath, Jain, Arpit, Singh, Parminder, Shetty, Naresh, Sathyanarayana, Srikanta Shamanna, Shah, Nalini, Chadha, Manoj Dharam, Bhandankar, Rajendra, Velayutham, Kumaravel, Marwah, Sudha, John, Mathew, Sahay, Rakesh Kumar, Adami, Silvano, Nuti, Ranuccio, Bianchi, Gerolamo, Brandi, Maria Luisa, Minisola, Salvatore, Fiore, Carmelo Erio, Rubinacci, Alessandro, Miyajima, Hisayuki, Yamane, Hiroo, Nakatani, Yuji, Okamoto, Sumiaki, Kuroda, Koji, Fujimori, Motoaki, Itabashi, Akira, Katayama, Kuniaki, Nakajo, Satoru, Somekawa, Yoshiaki, Ohsawa, Yoshimitsu, Tajima, Wataru, Mizuno, Katsunori, Mori, Shigeru, Kanabuchi, Takato, Hashizume, Hiroyuki, Oka, Nobuyuki, Hamada, Kazutoshi, Yamaguchi, Motoi, Hirahara, Fumiki, Atobe, Masaaki, Ohtake, Yoshiharu, Ichikawa, Shuichi, Onishi, Tomoyuki, Matsumoto, Kou, Nakamura, Tetsuro, Shirasawa, Eishi, Katayama, Ko, Takahashi, Mitsugu, Oguma, Tadanori, Matsui, Hideo, Katoh, Yoshiharu, Shigenobu, Keiichi, Onishi, Tsutomu, Shibukawa, Masato, Ikeda, Satoshi, Osaka, Kazuhiro, Kanda, Ryosuke, Inobe, Yoshito, Shigenobu, Masaharu, Hasegawa, Morimasa, Yamaji, Tetsuo, Miyazaki, Yu, Ito, Takayasu, Nakamura, Eisuke, Nagai, Shinji, Lim, Sung-Kil, Chung, Yoon-Sok, Shin, Chan-Soo, Min, Yong-Ki, Kim, Ghi Su, Yoon, Hyun Koo, Kang, Moo-Il, Yang, Kyu-Hyun, Park, Hyoung Moo, Kim, In Joo, Chung, Dong Jin, Chung, Ho Yeon, Jaundzeikare, Sandra, Andersone, Dace, Medne, Agita, Yaghi, Yasser, Alekna, Vidmantas, Kasiulevicius, Vytautas, Purtokaite - Labutiniene, Irina, Krasauskiene, Aurelija, Varanaviciene, Jurate, Basijokiene, Vida, Abraitiene, Agne, Radzeviciene, Lina, Walliser, Jesus, García Hernández, Pedro Alberto, Araujo, Maria Frida, Avila Armengol, Hilario Ernesto, De la Peña, Pilar, Tamayo, Juan, Zazueta, Beatriz, Cons, Fidencio, Gilchrist, Nigel Leslie, Reid, Ian Reginald, Leikis, Robert, Jones, Peter, Singh, Joe Gragrath Pradeep, Halse, Johan Inge, Syversen, Unni, Høivik, Hans Olav, Øfjord, Erik Snorre, Gulseth, Hans Christian, Elle, Sigbjørn, Norheim, Paal Dag, Calvo Quiroz, Armando A., Cesar Augusto, Pastor A., León Portocarrero, Manuel Gustavo, Vidal Neira, Luis Fernando, Chavez, Jose, Garro Barrera, Boris, Kuroiwa Sampei, Rita, Luis Fernando, Bellatín V., Oquelis Cabredo, Rogger, Castillo, Sonia, Morales, Agustin Miguel G, Tan, Perry Pua, Leagogo, Liberato Antonio C, Jr., Wang, Edward HM, Li-Yu, Julie T, Sawicki, Andrzej Z, Stasiuk, Barbara, Kania, Grzegorz, Lorenc, Roman, Sidorowicz-Bialynicka, Anna, Szczepanski, Leszek, Franek, Edward, Filip, Rafal, Sekula, Jan, Blicharski, Tomasz, Leszczynski, Piotr, Sewerynek, Ewa, Miazgowski, Tomasz, Milewicz, Andrzej, Dabrowska, Magda, Romaszko, Jerzy, Pluskiewicz, Wojciech, Wojnowski, Lukasz, Codreanu, Catalin, Bolosiu, Horatiu, Ionescu, Ruxandra, Zosin, Ioana, Macovei, Liviu, Bojinca, Mihai, Radulescu, Florin, Pop, Simona, Sarbu, Adrian, Benevolenskaya, Lidia I, Nasonov, Evgeny L, Rozhinskaya, Lyudmila Ya, Oganov, Raphael G, Rodionova, Svetlana S, Shlyakhto, Eugeny Vladimirovich, Trofimov, Vasiliy, Zotkin, Eugeny G, Zazerskaya, Irina E, Grineva, Elena N, Ershova, Olga, Lesnyak, Olga, Ostroumova, Olga D, Malichenko, Svetlana B, Pikhlak, Eduard G, Pilyaev, Valery G, Raskina, Tatiana, Zonova, Elena V, Shirinsky, Valery S, Dimic, Aleksandar N, Cobeljic, Goran, Vujovic, Svetlana, Ellis, Graham Charlston, Lipschitz, Stanley, De Villiers, Tobias Johannes, De Weerd, Albert Jan, Vally, Tasneem, Trinder, Yvonne, Coetsee, Jacobus Ludewikus, Davis, Charles Pierre, Nayiager, Savithree, Hough, Frans Stephanus, Oelofse, Louis F, van der Walt, Eugene, Lombaard, Johannes Jurgens, Blignaut, Suzanne, Govind, Uttam, Fouche, Leon Frederik, Kruger, Dawid Stephanus, Dalmeyer, Johannes Paul, Ferreira, Mada M, Escudero-Contreras, Alejandro, Muñoz Torres, Manuel, Hawkins Carranza, Federico, Perez Castrillon, Jose Luis, García Meijide, Juan Antonio, Jodar Gimeno, Esteban, Palacios Gil-Antuñana, Santiago, de Teresa Parreno, Luis, Martín Mola, Emilio, Alvarez Sanchez, Carmen, Lippuner, Kurt, Tsai, Keh-Sung, Tu, Shih-Te, Chen, Jung-Fu, Lee, Oscar Kuang-Sheng, Hsu, Wen-Wei, Grygorieva, Natalia Viktorivna, Povoroznyuk, Vladyslav Volodymyrovych, Korzh, Mykola Oleksiiovych, Loskutov, Oleksandr Levgeniiovych, Chukov, Andriy Borysovych, Sarmiento, Rex, Thomas, Hawys, Donnachie, Hugh, Pavel-Knox, Irina, Shaw, Hilary, Hassanin, Hana, Abdulhakim, Essam Eldin Ahmed, Savani, Naren, Bachmann, Gloria A, Barrett-Connor, Elizabeth, Binkley, Neil C, Bone, Henry G, Brandon, Donald M, Checketts, Darin David, Fraser, Neil J, Watts, Nelson B, Geller, Steven A, Gimbel, Joseph S, Greenwald, Maria White, Holt, Peter A, Johnston, Cyrus Conrad, Fang, Chien, Kiel, Douglas P, Klashman, David J, Lewiecki, E. Michael, Lowenstein, Mitchell B, McClung, Michael Roy, Nattrass, Susan M, Odio, Alberto, Levengood, Julie, Romaguera, Josefina, Saag, Kenneth G, Sebai, Mohamed Bassam, Snyder, Brian, Kutner, Mark Eliot, Streja, Dan, Schwartz, Elliott P, Christiansen, Mark G, McClung, Michael R, O'Donoghue, Michelle L, Papapoulos, Socrates E, Bone, Henry, Langdahl, Bente, Reid, Ian R, Cavallari, Ilaria, Bonaca, Marc P, Wiviott, Stephen D, de Villiers, Tobias, Ling, Xu, Nakamura, Toshitaka, Rodriguez-Portales, Jose Adolfo, Zanchetta, José, Zerbini, Cristiano A F, Park, Jeong-Gun, Im, KyungAh, Cange, Abby, Grip, Laura T, Heyden, Norman, DaSilva, Carolyn, Cohn, Dosinda, Massaad, Rachid, Scott, Boyd B, Verbruggen, Nadia, Gurner, Deborah, Miller, Deborah L, Blair, Micki L, Polis, Adam B, Stoch, S Aubrey, Santora, Arthur, Lombardi, Antonio, Leung, Albert T, Kaufman, Keith D, and Sabatine, Marc S

Published
2019
Full Text
View/download PDF

6. Guselkumab in Patients With Moderately to Severely Active Ulcerative Colitis: QUASAR Phase 2b Induction Study

Author

Peyrin-Biroulet, Laurent, primary, Allegretti, Jessica R., additional, Rubin, David T., additional, Bressler, Brian, additional, Germinaro, Matthew, additional, Huang, Kuan-Hsiang (Gary), additional, Shipitofsky, Nicole, additional, Zhang, Hongyan, additional, Wilson, Rebbecca, additional, Han, Chenglong, additional, Feagan, Brian G., additional, Sandborn, William J., additional, Panés, Julian, additional, Hisamatsu, Tadakazu, additional, Lichtenstein, Gary R., additional, Sands, Bruce E., additional, Dignass, Axel, additional, Abrahamovych, Orest, additional, Afanasieva, Halyna, additional, Aitova, Lilia, additional, Altintas, Engin, additional, Altwegg, Romain, additional, Andreev, Pavel, additional, Aomatsu, Kazuki, additional, Augustyn, Monika, additional, Balestrieri, Paola, additional, Begun, Jakob, additional, Brunatto, Luciana, additional, Bulgheroni, Diego, additional, Bunkova, Elena, additional, Cabello, Mercedes, additional, Cao, Qian, additional, Caprioli, Flavio, additional, Cerqueira, Rute, additional, Chen, Baili, additional, Chen, Chou-Chen, additional, Chen, Chou-Pin, additional, Chiu, Cheng-Tang, additional, Choi, Chang Hwan, additional, Cicala, Michele, additional, Datsenko, Olena, additional, Dewint, Pieter, additional, Domenech, Eugeni, additional, Dutré, Joris, additional, Duvall, George, additional, Fernandez, Juan, additional, Filip, Rafal, additional, Fogel, Ronald, additional, Fowler, Sharyle, additional, Fujii, Toshimitsu, additional, Fukata, Masayuki, additional, Furumoto, Yohei, additional, Gasbarrini, Antonio, additional, Gawdis-Wojnarska, Beata, additional, Gilletta, Cyrielle, additional, Gionchetti, Paolo, additional, Goldin, Eran, additional, Golovchenko, Oleksandr, additional, Gonciarz, Maciej, additional, Gonen, Can, additional, Segura, Gaston Gonzalez, additional, Gridnyev, Oleksii, additional, Gyokeres, Tibor, additional, Hébuterne, Xavier, additional, Hedin, Charlotte, additional, Hellström, Per, additional, Hilmi, Ida Normiha, additional, Horný, Ivo, additional, Horvat, Gyula, additional, Hoshi, Namiko, additional, Hrdlicka, Ludek, additional, Ishihara, Shunji, additional, Ivanishyn, Olha, additional, Jang, Byung Ik, additional, Junior, Odery, additional, Kagaya, Takashi, additional, Kanmura, Shuji, additional, Karakina, Marina, additional, Katsuhiko, Nakai, additional, Kierkus, Jaroslaw, additional, Kim, Hyo Jong, additional, Kim, Tae-Oh, additional, Kim, Young-Ho, additional, Kiss, Gyula G., additional, Klaus, Jochen, additional, Kleczkowski, Dariusz, additional, Klopocka, Maria, additional, Kobayashi, Taku, additional, Kobielusz-Gembala, Iwona, additional, Koo, Ja Seol, additional, Kopon, Adam, additional, Kravchenko, Tetiana, additional, Kudo, Masatoshi, additional, Kwon, Kwang An, additional, Lago, Paula, additional, Laharie, David, additional, Lawrance, Ian, additional, Leszczyszyn, Jaroslaw, additional, Li, Yan, additional, Lukas, Milan, additional, Maaser, Christian, additional, Maemoto, Atsuo, additional, Marusawa, Hiroyuki, additional, McBride, Matthew, additional, Mendu, Shoba, additional, Miheller, Pal, additional, Miyabayashi, Hideharu, additional, Mohl, Wolfgang, additional, Moore, Gregory, additional, Motoya, Satoshi, additional, Murali, Narayanachar, additional, Naem, Mohammed, additional, Nakajima, Koichi, additional, Nakamoto, Yasunari, additional, Nancey, Stéphane, additional, Neto, Joaquim, additional, Onizawa, Michio, additional, Ono, Yohei, additional, Osada, Taro, additional, Osipenko, Marina, additional, Owczarek, Danuta, additional, Patel, Bhaktasharan, additional, Patel, Kamal, additional, Petrova, Elina, additional, Poroshina, Elena, additional, Portela, Francisco, additional, Prystupa, Lyudmyla, additional, Rivero, Monserrat, additional, Roblin, Xavier, additional, Romatowski, Jacek, additional, Rydzewska, Grazyna, additional, Saibeni, Simone, additional, Sakuraba, Hirotake, additional, Samaan, Mark, additional, Schultz, Michael, additional, Schulze, Joerg, additional, Sedghi, Shahriar, additional, Seidler, Ursula, additional, Shin, Sung Jae, additional, Stanislavchuk, Mykola, additional, Stokesberry, David, additional, Suzuki, Takayoshi, additional, Taguchi, Hiroki, additional, Tankova, Lyudmila, additional, Thin, Lena, additional, Tkachev, Alexander, additional, Torrealba, Leyanira, additional, Tsarynna, Nataliia, additional, Tulassay, Zsolt, additional, Ueo, Tetsuya, additional, Valuyskikh, Ekaterina, additional, Vasilevskaya, Olga, additional, Viamonte, Manuel, additional, Wei, Shu-Chen, additional, Weisshof, Roni, additional, Wojcik, Katarzyna, additional, Ye, Byong Duk, additional, Yen, Hsu-Heng, additional, Yoon, Hyuk, additional, Yoshida, Kosuke, additional, Yurkiv, Andriy, additional, Zaha, Osamu, additional, and Zhan, Qiang, additional

Published
2023
Full Text
View/download PDF

7. S1063 Improvement in Inflammatory Biomarker Levels Through Week 12 in Moderately to Severely Active Ulcerative Colitis Patients Treated With Guselkumab: Results From the Phase 3 QUASAR Induction Study

Author

Hisamatsu, Tadakazu, primary, Peyrin-Biroulet, Laurent, additional, Dignass, Axel, additional, Huang, Kuan-Hsiang G., additional, Germinaro, Matthew, additional, Houck, Nicole, additional, Miao, Ye, additional, Zhang, Hongyan, additional, Argollo, Marjorie, additional, Takeuchi, Ken, additional, Filip, Rafal, additional, Allegretti, Jessica R., additional, Feagan, Brian G., additional, and Sands, Bruce E., additional

Published
2023
Full Text
View/download PDF

8. Primary Hypogammaglobulinaemia with Inflammatory Bowel Disease-Like Features: An ECCO CONFER Multicentre Case Series

Author

MS MDL 1, Infection & Immunity, Albshesh, Ahmad, Eder, Piotr, Ribaldone, Davide Giuseppe, Oldenburg, Bas, de Boer, Nanne K, Mantzaris, Gerassimos J, Savarino, Edoardo Vincenzo, Dragoni, Gabriele, Weisshof, Roni, Truyens, Marie, Festa, Stefano, Maillard, Michel H, Capirchio, Lena, Filip, Rafal, Theodoraki, Eirini, Kopylov, Uri, MS MDL 1, Infection & Immunity, Albshesh, Ahmad, Eder, Piotr, Ribaldone, Davide Giuseppe, Oldenburg, Bas, de Boer, Nanne K, Mantzaris, Gerassimos J, Savarino, Edoardo Vincenzo, Dragoni, Gabriele, Weisshof, Roni, Truyens, Marie, Festa, Stefano, Maillard, Michel H, Capirchio, Lena, Filip, Rafal, Theodoraki, Eirini, and Kopylov, Uri

Published
2022

9. Ustekinumab versus adalimumab for induction and maintenance therapy in biologic-naive patients with moderately to severely active Crohn's disease: a multicentre, randomised, double-blind, parallel-group, phase 3b trial

Author

Sands, Bruce E, primary, Irving, Peter M, additional, Hoops, Timothy, additional, Izanec, James L, additional, Gao, Long-Long, additional, Gasink, Christopher, additional, Greenspan, Andrew, additional, Allez, Matthieu, additional, Danese, Silvio, additional, Hanauer, Stephen B, additional, Jairath, Vipul, additional, Kuehbacher, Tanja, additional, Lewis, James D, additional, Loftus, Edward V, additional, Mihaly, Emese, additional, Panaccione, Remo, additional, Scherl, Ellen, additional, Shchukina, Oksana B, additional, Sandborn, William J, additional, Afzali, Anita, additional, Aitova, Lilia, additional, Aldeguer i Mante, Xavier, additional, Altorjay, István, additional, Argüelles Arias, Federico, additional, Armuzzi, Alessandro, additional, Augustyn, Monika, additional, Bafutto, Mauro, additional, Barrio, Jesus, additional, Begun, Jakob, additional, Behrend, Clint, additional, Bezemer, Geert, additional, Bonnaud, Guillaume, additional, Brankovic, Marija, additional, Byung, Ik Jang, additional, Calvet Calvo, Xavier, additional, Chachu, Karen, additional, Chebli, Julio Maria Fonseca, additional, Cheon, Jae Hee, additional, Cichoz-Lach, Halina, additional, Clark, Larry, additional, Cummings, Fraser, additional, Dalal, Kunal, additional, De Boer, Nanne, additional, De Lourdes Ferrari, Maria, additional, Désilets, Etienne, additional, Dugalic, Predrag, additional, Duvall, George, additional, Fedorishina, Olga, additional, Filip, Rafal, additional, Flores, Cristina, additional, Fogel, Ronald, additional, Fon, James, additional, Frankel, Michael, additional, Friedenberg, Keith, additional, Fries, Walter, additional, Galina, Vassileva, additional, Gietka, Piotr, additional, Goel, Rishi, additional, Hasselblatt, Peter, additional, Herfarth, Hans, additional, Herszényi, László, additional, Hindryckx, Pieter, additional, Hoentjen, Frank, additional, Horjus Talabur Horje, Carmen, additional, Iduru, Satish, additional, Irving, Peter, additional, Isfort, Robert, additional, Jones, Michael, additional, Kalimullina, Dilara, additional, Katz, Jeffry, additional, Kaur, Manreet, additional, Khurana, Sunil K, additional, Kim, Joo Sung, additional, Kim, Youngho, additional, Kleczkowski, Dariusz, additional, Knezevic, Slavko, additional, Knoll, Aaron, additional, Korman, Louis Y, additional, Kotzev, Iskren, additional, Kulyapin, Andrey, additional, Lee, Kang Moon, additional, Leemreis, Desiree, additional, Leszczyszyn, Jaroslaw, additional, Limdi, Jimmy, additional, Lissauer, Jack, additional, Loftus, Edward, additional, Malecka-Panas, Ewa, additional, Marshall, John, additional, Mihály, Emese, additional, Milan, Lukas, additional, Monteleone, Giovanni, additional, Nagorni, Aleksandar, additional, Owczarek, Danuta, additional, Palekar, Nichole, additional, Park, Young Soo, additional, Park, Sang Hyoung, additional, Parra, Rogério, additional, Patai, Árpád, additional, Patel, Kamal, additional, Patel, Bhaktasharan, additional, Pershko, Anatoly, additional, Petrova, Elina, additional, Pineton de Chambrun, Guillaume, additional, Randall, Charles, additional, Riestra Menendez, Sabino, additional, Ritter, Timothy, additional, Rivero, Montserrat, additional, Roblin, Xavier, additional, Rocca, Rodolfo, additional, Romatowski, Jacek, additional, Rydzewska, Grazyna, additional, Saibeni, Simone, additional, Salzberg, Bruce, additional, Sarles, Harry, additional, Saunders, John, additional, Savarino, Edoardo Vincenzo, additional, Serclova, Zuzana, additional, Shchukina, Oksana, additional, Siegel, Jonathan, additional, Soofi, Najm, additional, Sparrow, Miles, additional, Stokesberry, David, additional, Suiter, Daniel, additional, Svorcan, Petar, additional, Tkachev, Alexander, additional, Tsonev, Nikolay, additional, Tünde, Kristóf, additional, Ulbrych, Jan, additional, Vanasek, Tomas, additional, Varga, Márta, additional, Vermeire, Severine, additional, Vicente Lidon, Raquel, additional, Weiss, Michael L, additional, Wesley, Emma, additional, Winstead, Nathaniel, additional, Wojcik, Katarzyna, additional, Wypych, Joanna, additional, Zaltman, Cyrla, additional, and Zdena, Zadorova, additional

Published
2022
Full Text
View/download PDF

11. Tu1445: EFFECT OF PHARMACOKINETICS AND IMMUNOGENICITY ON CLINICAL AND ENDOSCOPIC EFFICACY IN PATIENTS WITH MODERATELY-TO-SEVERELY ACTIVE CROHN'S DISEASE: RESULTS FROM THE SEAVUE STUDY

Author

Panaccione, Remo, primary, Sands, Bruce E., additional, Danese, Silvio, additional, Irving, Peter M., additional, Hoops, Timothy, additional, Izanec, James L., additional, Ma, Tony, additional, Adedokun, Omoniyi J., additional, Gasink, Christopher, additional, Kuehbacher, Tanja, additional, Patel, Kamal V, additional, Filip, Rafal, additional, Allez, Matthieu, additional, Scherl, Ellen J., additional, and Sandborn, William J., additional

Published
2022
Full Text
View/download PDF

12. Gastroenteropancreatic Neuroendocrine Neoplasms in Patients with Inflammatory Bowel Disease: An ECCO CONFER Multicentre Case Series

Author

Festa, Stefano, primary, Zerboni, Giulia, additional, Derikx, Lauranne A A P, additional, Ribaldone, Davide Giuseppe, additional, Dragoni, Gabriele, additional, Buskens, Christianne, additional, van Dijkum, Els Nieveen, additional, Pugliese, Daniela, additional, Panzuto, Francesco, additional, Krela-Kaźmierczak, Iwona, additional, Mintz, Hilla Reiss, additional, Shitrit, Ariella Bar-Gil, additional, Chaparro, Marìa, additional, Gisbert, Javier P, additional, Kopylov, Uri, additional, Teich, Niels, additional, Vainer, Elez, additional, Nagtegaal, Iris, additional, Hoentjen, Frank, additional, Garcia, Maria Jose, additional, Filip, Rafal, additional, Foteinogiannopoulou, Kalliopi, additional, Koutroubakis, Ioannis E, additional, Argollo, Marjorie, additional, van Wanrooij, Roy L J, additional, Laja, Hendrik, additional, Lobaton, Triana, additional, Truyens, Marie, additional, Molnar, Tamas, additional, Savarino, Edoardo, additional, Aratari, Annalisa, additional, Papi, Claudio, additional, and Goren, Idan, additional

Published
2021
Full Text
View/download PDF

13. Primary Hypogammaglobulinaemia with Inflammatory Bowel Disease-Like Features: An ECCO CONFER Multicentre Case Series

Author

Albshesh, Ahmad, primary, Eder, Piotr, additional, Ribaldone, Davide Giuseppe, additional, Oldenburg, Bas, additional, de Boer, Nanne K, additional, Mantzaris, Gerassimos J, additional, Savarino, Edoardo Vincenzo, additional, Dragoni, Gabriele, additional, Weisshof, Roni, additional, Truyens, Marie, additional, Festa, Stefano, additional, Maillard, Michel H, additional, Capirchio, Lena, additional, Filip, Rafal, additional, Theodoraki, Eirini, additional, and Kopylov, Uri, additional

Published
2021
Full Text
View/download PDF

14. Primary hypogammaglobulinemia with IBD-like features: An ECCO CONFER Multicenter Case Series

Author

Albshesh, Ahmad, Eder, Piotr, Ribaldone, Davide Giuseppe, Oldenburg, Bas, de Boer, Nanne K, Mantzaris, Gerassimos J, Savarino, Edoardo Vincenzo, Dragoni, Gabriele, Weisshof, Roni, Truyens, Marie, Festa, Stefano, Maillard, Michel H, Capirchio, Lena, Filip, Rafal, Theodoraki, Eirini, and Kopylov, Uri

Subjects
inflammatory bowel disease, IBD-like features, primary hypogammaglobulinemia, immunodeficiency
Published
2021

15. Primary hypogammaglobulinemia with IBD-like features: An ECCO CONFER Multicenter Case Series.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de gastro-entérologie, Albshesh, Ahmad, Eder, Piotr, Ribaldone, Davide Giuseppe, Oldenburg, Bas, de Boer, Nanne K, Mantzaris, Gerassimos J, Savarino, Edoardo Vincenzo, Dragoni, Gabriele, Weisshof, Roni, Truyens, Marie, Festa, Stefano, Maillard, Michel H, Capirchio, Lena, Filip, Rafal, Theodoraki, Eirini, Kopylov, Uri, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de gastro-entérologie, Albshesh, Ahmad, Eder, Piotr, Ribaldone, Davide Giuseppe, Oldenburg, Bas, de Boer, Nanne K, Mantzaris, Gerassimos J, Savarino, Edoardo Vincenzo, Dragoni, Gabriele, Weisshof, Roni, Truyens, Marie, Festa, Stefano, Maillard, Michel H, Capirchio, Lena, Filip, Rafal, Theodoraki, Eirini, and Kopylov, Uri

Abstract

Hypogammaglobulinemia is a disorder characterized by low serum immunoglobulin levels and had high prevalence of gastrointestinal manifestations. In some cases, clinical and endoscopic features are indistinguishable from those of inflammatory bowel disease (IBD). This was a multicenter case series performed as a part of the European Crohn's and Colitis Organisation (ECCO) Collaborative Network of Exceptionally Rare case reports (CONFER) project. This report includes 27 patients with primary hypogammaglobulinemia and IBD-like features [20 males and 7 females, median age 45.6 years (Interquartile range (IQR) 35.2-59]. Crohn's disease-like features were noted in 23 patients, four patients had ulcerative colitis-like features. The diagnosis of hypogammaglobulinemia preceded IBD-like features diagnosis in 20 patients (median of 7 years prior, IQR 2.6-20.6 years), and followed IBD-like features appearance in 7 cases (median of one year after, IQR 0.45-5.6 years).Hypogammaglobulinemia etiologies were common variable immunodeficiency (66.6%), agammaglobulinemia (7.4%), selective IgA-deficiency (11.1%), Goods syndrome (7.4%), IgG subclass deficiency with IgA deficiency (3.7%) and hyper-IgM (3.7%). In addition to antibiotics and intravenous immunoglobulin (IVIG) for hypogammaglobulinemia, 12 patients received IBD-related treatment including 5-ASA (2 patients), corticosteroids (1 patient), thiopurines (3 patients), anti-TNFs (4 patients) and vedolizumab (2 patients). By the end of the follow-up [44.5 months (IQR 18-81)], 21/27 (77%) patients were in clinical remission. This case series describes IBD-like features in patients with hypogammaglobulinemia. The diagnosis of IBD-like features mainly occurred after that of hypogammaglobulinemia, with successful recovery in the majority of cases after appropriate treatment.

Published
2021

16. Fr531 EFFICACY AND SAFETY OF FILGOTINIB AS MAINTENANCE THERAPY FOR PATIENTS WITH MODERATELY TO SEVERELY ACTIVE ULCERATIVE COLITIS: RESULTS FROM THE PHASE 2B/3 SELECTION STUDY

Author

Peyrin-Biroulet, Laurent, primary, Loftus, Edward V., additional, Danese, Silvio, additional, Vermeire, Séverine, additional, Sandborn, William J., additional, Fogel, Ronald P., additional, Nijhawan, Sandeep, additional, Kempinski, Radoslaw, additional, Filip, Rafal, additional, Hospodarskyy, Ihor, additional, McNally, John, additional, Yun, Chohee, additional, Zhao, Sally, additional, Liu, Xiaopeng, additional, Tasset, Chantal T., additional, Besuyen, Robin, additional, Watanabe, Mamoru, additional, Schreiber, Stefan, additional, Rogler, Gerhard, additional, Hibi, Toshifumi, additional, and Feagan, Brian G., additional

Published
2021
Full Text
View/download PDF

17. First-pass metabolism limits the intestinal absorption of enteral [alpha]-ketoglutarate in young pigs

Author

Lambert, Barry D., Filip, Rafal, Stoll, Barbara, Junghans, Peter, Derno, Michael, Hennig, Ulf, Souffrant, Wolfgang B., Pierzynowski, Stefan, and Burrin, Douglas G.

Subjects
Swine -- Physiological aspects, Swine -- Research, Metabolism -- Research, Food/cooking/nutrition
Abstract

Our results in a previous study indicated that the portal absorption of intragastrically fed [alpha]-ketoglutarate (AKG) was limited in young pigs. Our aim was to quantify the net portal absorption, first-pass metabolism, and whole-body flux of enterally infused AKG. In study 1, we quantified the net portal nutrient absorption in young pigs (n = 9) given an intraduodenal infusion of milk replacer [10 mL/(kg * h)] and either saline (control) or 930 [micro]mol/(kg. h) AKG for 4 h. In study 2, we quantified the luminal disappearance of a duodenal AKG bolus in young pigs (n = 7). In study 3, we quantified the whole-body kinetics of [sup.13]C-AKG metabolism when infused either enterally (n = 9) or intravenously (n = 9) in young pigs. In study 1, when compared with the control group, enteral AKG infusion increased (P< 0.01) the arterial (13.8 [+ or -] 1.7 vs. 27.4 [+ or -] 3.6 [micro]mol/L) and portal (22.0 [+ or -] 1.4 vs. 64.6 [+ or -] 5.9 [micro]mol/L) AKG concentrations and the net portal absorption of AKG [19.7 [+ or -] 2.8 vs. 95.2 [+ or -] 12.0 [micro]mol/(kg * h)]. The mean fractional portal appearance of enterally infused AKG was 10.23 [+ or -] 1.3%. In study 2, the luminal disappearance of AKG was 663 [micro]mol/(kg * h), representing 63% of the intraduodenal dose. In study 3, the wholebody [sup.13]C-AKG flux [4685 [+ or -] 666 vs. 801 [+ or -] 67 [micro]mol/(kg * h)] was higher (P < 0.05) when given enterally than intravenously, but [sup.13]C[O.sub.2] recovery was not different (37.3 [+ or -] 1.0 vs. 36.2 [+ or -] 0.7%dose). The first-pass splanchnic [sup.13]C-AKG utilization was ~80%, of which 30% was oxidized to [sup.13]C[O.sub.2]. We conclude that the intestinal absorption of AKG is limited in young pigs largely due to substantial first-pass gastrointestinal metabolism.

Published
2006

21. Diagnosis and Outcome of Extranodal Primary Intestinal Lymphoma in Inflammatory Bowel Disease: An ECCO CONFER Case Series.

Author

Phillips, Frank, Verstockt, Bram, Ribaldone, Davide Giuseppe, Guerra, Ivan, Teich, Niels, Katsanos, Konstantinos, Filip, Rafal, Molner, Tamas, Karmiris, Konstantinos, and Investigators, ECCO CONFER

Abstract

Background There is a small but measurable increased risk of lymphoma in inflammatory bowel disease [IBD], with a suggestion that primary intestinal lymphoma [PIL] in IBD is associated with inflamed tissue and immunosuppressant use, mainly thiopurines. Methods This multicentre case series was supported by the European Crohn's and Colitis Organisation [ECCO] and performed as part of the Collaborative Network of Exceptionally Rare case reports [CONFER] project. Clinical data were recorded in a standardized case report form. Results Fifteen patients with intestinal lymphoma from eight centres were included (12 males, 11 patients with Crohn's disease [CD], mean age 47.8 [±16.4 SD, range 26–76] years at lymphoma diagnosis). Lymphoma type was diffuse large B-cell lymphoma [DLBCL] in eight, Hodgkin's disease in two, mucosa-associated lymphoid tissue [MALT] lymphoma in three, and single cases of immunoblastic lymphoma and indolent T-cell lymphoma. Lymphoma was located within the IBD-affected area in ten patients. At lymphoma diagnosis, nine patients had a history of azathioprine or anti-tumour necrosis factor [TNF] use. Lymphoma was diagnosed at a mean time of 10.4 [±7.07, 1–24] years after IBD diagnosis in 11 patients, prior to IBD in two and concurrently in two. Sustained remission over a median follow-up time of 6.5 [1.5–20] years was achieved in ten patients after treatment; five of them had started biological therapy [including anti-TNFs, vedolizumab and ustekinumab] for active CD subsequent to their PIL treatment. Conclusion In this small case series, two-thirds of patients developed lymphoma in the IBD-affected area, and almost two-thirds had a history of thiopurine or anti-TNF use. Biologics were restarted without recurrence of lymphoma in half of the remitters. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

22. Primary Hypogammaglobulinaemia with Inflammatory Bowel Disease-Like Features: An ECCO CONFER Multicentre Case Series.

Author

Albshesh, Ahmad, Eder, Piotr, Ribaldone, Davide Giuseppe, Oldenburg, Bas, Boer, Nanne K de, Mantzaris, Gerassimos J, Savarino, Edoardo Vincenzo, Dragoni, Gabriele, Weisshof, Roni, Truyens, Marie, Festa, Stefano, Maillard, Michel H, Capirchio, Lena, Filip, Rafal, Theodoraki, Eirini, and Kopylov, Uri

Abstract

Background Hypogammaglobulinaemia is a disorder characterized by low serum immunoglobulin levels and a high prevalence of gastrointestinal manifestations. In some cases, clinical and endoscopic features are indistinguishable from those of inflammatory bowel disease [IBD]. Methods This was a multicentre case series performed as a part of the European Crohn's and Colitis Organisation [ECCO] Collaborative Network of Exceptionally Rare case reports [CONFER] project. Results This report includes 27 patients with primary hypogammaglobulinaemia and IBD-like features: 20 males and seven females, median age 45.6 years (interquartile range [IQR] 35.2–59). Crohn's disease-like features were noted in 23 patients, and four patients had ulcerative colitis-like features. The diagnosis of hypogammaglobulinaemia preceded a diagnosis of IBD-like features in 20 patients [median of 7 years prior, IQR 2.6–20.6 years], and followed the appearance of IBD-like features in seven cases [median of 1 year after, IQR 0.45–5.6 years]. Hypogammaglobulinaemia aetiologies were common variable immunodeficiency [66.6%], agammaglobulinaemia [7.4%], selective IgA-deficiency [11.1%], Good's syndrome [7.4%], IgG subclass deficiency with IgA deficiency [3.7%] and hyper-IgM [3.7%]. In addition to antibiotics and intravenous immunoglobulin [IVIG] for hypogammaglobulinaemia, 12 patients received IBD-related treatment including 5-aminosalicylate agents [two patients], corticosteroids [one patient], thiopurines [three patients], anti-tumour necrosis factor [four patients] and vedolizumab [two patients]. By the end of the follow-up (44.5 months [IQR 18–81]), 21/27 [77%] patients were in clinical remission. Conclusion This case series describes IBD-like features in patients with hypogammaglobulinaemia. The diagnosis of IBD-like features mainly occurred after that of hypogammaglobulinaemia, with successful recovery in the majority of cases after appropriate treatment. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

23. Colon cleansing efficacy and safety with 1 L NER1006 versus sodium picosulfate with magnesium citrate: a randomized phase 3 trial

Author

Schreiber, Stefan, Baumgart, Daniel C., Drenth, J.P.H., Filip, Rafal S., Clayton, Lucy B., Hylands, Kerry, Repici, Alessandro, Hassan, Cesare, Schreiber, Stefan, Baumgart, Daniel C., Drenth, J.P.H., Filip, Rafal S., Clayton, Lucy B., Hylands, Kerry, Repici, Alessandro, and Hassan, Cesare

Abstract

Contains fulltext : 201082.pdf (publisher's version ) (Closed access)

Published
2019

24. Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study

Author

McClung, Michael R, primary, O'Donoghue, Michelle L, additional, Papapoulos, Socrates E, additional, Bone, Henry, additional, Langdahl, Bente, additional, Saag, Kenneth G, additional, Reid, Ian R, additional, Kiel, Douglas P, additional, Cavallari, Ilaria, additional, Bonaca, Marc P, additional, Wiviott, Stephen D, additional, de Villiers, Tobias, additional, Ling, Xu, additional, Lippuner, Kurt, additional, Nakamura, Toshitaka, additional, Reginster, Jean-Yves, additional, Rodriguez-Portales, Jose Adolfo, additional, Roux, Christian, additional, Zanchetta, José, additional, Zerbini, Cristiano A F, additional, Park, Jeong-Gun, additional, Im, KyungAh, additional, Cange, Abby, additional, Grip, Laura T, additional, Heyden, Norman, additional, DaSilva, Carolyn, additional, Cohn, Dosinda, additional, Massaad, Rachid, additional, Scott, Boyd B, additional, Verbruggen, Nadia, additional, Gurner, Deborah, additional, Miller, Deborah L, additional, Blair, Micki L, additional, Polis, Adam B, additional, Stoch, S Aubrey, additional, Santora, Arthur, additional, Lombardi, Antonio, additional, Leung, Albert T, additional, Kaufman, Keith D, additional, Sabatine, Marc S, additional, Mautalén, Carlos Alfredo, additional, Man, Zulema, additional, Zanchetta, Jose Ruben, additional, Magaril, Clelia Haydee, additional, Sambrook, Philip, additional, Geusens, Piet, additional, Goemaere, Stefan, additional, Albergaria, Ben Hur, additional, Zerbini, Cristiano Augusto de Freitas, additional, Castro, Marise Lazaretti, additional, Gregorio, Luiz Henrique, additional, Stoilov, Rumen, additional, Borissova, Anna-Maria I, additional, Hristozov, Kiril Hristov, additional, Temelkova, Nataliya L, additional, Daskalova, Ivona Kirilova, additional, Kuzmanova, Stefka Ivanova, additional, Yaneva-Bichovska, Daniela, additional, Batalov, Anastas Zgurov, additional, Riedemann, Pablo, additional, Rodriguez Portales, José Adolfo, additional, Tang, Hai, additional, Zhu, hanmin, additional, Zhang, Zhenlin, additional, Chao, Aijun, additional, Hu, Yali, additional, Liu, Zhiming, additional, Lu, Juming, additional, Qiu, Mingcai, additional, Gao, Xin, additional, Zhang, Shaofen, additional, Xu, Ling, additional, Xia, Weibo, additional, Liao, Eryuan, additional, Yang, Wenying, additional, Wu, Wen, additional, Dai, Kerong, additional, Hu, Renming, additional, Jaller, Juan Jose, additional, Cabal, Francisco, additional, Molina, José Fernando, additional, Cure Cure, Carlos A, additional, Yupanqui-Lozno, Hernan, additional, Chalem, Philippe, additional, Londono, John, additional, Abello, Mauricio, additional, Tobias, Edgardo D, additional, Otero, William, additional, Nikolic, Tatjana, additional, Miskic, Blazenka, additional, Stepan, Jan, additional, Vyskocil, Vaclav, additional, Novosad, Libor, additional, Slesinger, Jan, additional, Novosad, Pavel, additional, Vlckova, Erika, additional, Bortlik, Ladislav, additional, Dokoupilova, Eva, additional, Hala, Tomas, additional, Jensen, Jens-Erik Beck, additional, Brixen, Kim Torsten, additional, Langdahl, Bente Lomholt, additional, Schwarz, Peter, additional, Eskildsen, Peter Claes, additional, Eiken, Pia Agnete, additional, Hermann, Anne Pernille, additional, Gram, Jeppe, additional, Schou, Maiken Brix, additional, Alexandersen, Peter, additional, Nedergaard, Bettina, additional, Mejía, Dolores Magdalena, additional, Estrella De Henriquez, Lourdes, additional, Páez, Norka, additional, Velazco, Casimiro, additional, Valter, Ivo, additional, Vahula, Kadri-Liina, additional, Kull, Ingrid, additional, Maasalu, Katre, additional, Chapurlat, Roland, additional, Fardellone, Patrice, additional, Benhamou, Claude Laurent, additional, Weryha, Georges, additional, Herkt, Volkmar, additional, Martz, Rene, additional, Nischik, Ruth, additional, Spieler, Wolfgang, additional, Contzen, Christel, additional, Felsenberg, Dieter, additional, Frieling, Isolde, additional, Frahm, Eike, additional, Briones, Henry, additional, Sandoval, Boris, additional, Barrios, Patricia, additional, García, Abraham, additional, Avendaño, Carlos, additional, González, Magdalena, additional, Guerra, Jeremías, additional, Tuna, Maria, additional, Díaz, Olga Marina, additional, Samayoa, Eduardo, additional, López, Edgar, additional, Barrera, José Raúl, additional, Palencia, Mainor, additional, Cifuentes, Mayra, additional, Alvarado, Georgina, additional, López, Miriam, additional, Chavez, Nilmo, additional, Haase, Franklin, additional, Rivera, Ruddy, additional, González, Claudio, additional, Tan, Kathryn, additional, Leung, Ping Chung, additional, Mandalam, Sheshadri, additional, Pitale, Shailesh Umakant, additional, Bantwal, Ganapathi, additional, Ammini, Ariachery Chinamma, additional, Shaikh, Shehla Sajid Akhta, additional, Kanakatte Mylariah, Prasanna Kumar, additional, Dharmalingam, Mala, additional, Mukhopadhyay, Satinath, additional, Jain, Arpit, additional, Singh, Parminder, additional, Shetty, Naresh, additional, Sathyanarayana, Srikanta Shamanna, additional, Shah, Nalini, additional, Chadha, Manoj Dharam, additional, Bhandankar, Rajendra, additional, Velayutham, Kumaravel, additional, Marwah, Sudha, additional, John, Mathew, additional, Sahay, Rakesh Kumar, additional, Adami, Silvano, additional, Nuti, Ranuccio, additional, Bianchi, Gerolamo, additional, Brandi, Maria Luisa, additional, Minisola, Salvatore, additional, Fiore, Carmelo Erio, additional, Rubinacci, Alessandro, additional, Miyajima, Hisayuki, additional, Yamane, Hiroo, additional, Nakatani, Yuji, additional, Okamoto, Sumiaki, additional, Kuroda, Koji, additional, Fujimori, Motoaki, additional, Itabashi, Akira, additional, Katayama, Kuniaki, additional, Nakajo, Satoru, additional, Somekawa, Yoshiaki, additional, Ohsawa, Yoshimitsu, additional, Tajima, Wataru, additional, Mizuno, Katsunori, additional, Mori, Shigeru, additional, Kanabuchi, Takato, additional, Hashizume, Hiroyuki, additional, Oka, Nobuyuki, additional, Hamada, Kazutoshi, additional, Yamaguchi, Motoi, additional, Hirahara, Fumiki, additional, Atobe, Masaaki, additional, Ohtake, Yoshiharu, additional, Ichikawa, Shuichi, additional, Onishi, Tomoyuki, additional, Matsumoto, Kou, additional, Nakamura, Tetsuro, additional, Shirasawa, Eishi, additional, Katayama, Ko, additional, Takahashi, Mitsugu, additional, Oguma, Tadanori, additional, Matsui, Hideo, additional, Katoh, Yoshiharu, additional, Shigenobu, Keiichi, additional, Onishi, Tsutomu, additional, Shibukawa, Masato, additional, Ikeda, Satoshi, additional, Osaka, Kazuhiro, additional, Kanda, Ryosuke, additional, Inobe, Yoshito, additional, Shigenobu, Masaharu, additional, Hasegawa, Morimasa, additional, Yamaji, Tetsuo, additional, Miyazaki, Yu, additional, Ito, Takayasu, additional, Nakamura, Eisuke, additional, Nagai, Shinji, additional, Lim, Sung-Kil, additional, Chung, Yoon-Sok, additional, Shin, Chan-Soo, additional, Min, Yong-Ki, additional, Kim, Ghi Su, additional, Yoon, Hyun Koo, additional, Kang, Moo-Il, additional, Yang, Kyu-Hyun, additional, Park, Hyoung Moo, additional, Kim, In Joo, additional, Chung, Dong Jin, additional, Chung, Ho Yeon, additional, Jaundzeikare, Sandra, additional, Andersone, Dace, additional, Medne, Agita, additional, Yaghi, Yasser, additional, Alekna, Vidmantas, additional, Kasiulevicius, Vytautas, additional, Purtokaite - Labutiniene, Irina, additional, Krasauskiene, Aurelija, additional, Varanaviciene, Jurate, additional, Basijokiene, Vida, additional, Abraitiene, Agne, additional, Radzeviciene, Lina, additional, Walliser, Jesus, additional, García Hernández, Pedro Alberto, additional, Araujo, Maria Frida, additional, Avila Armengol, Hilario Ernesto, additional, De la Peña, Pilar, additional, Tamayo, Juan, additional, Zazueta, Beatriz, additional, Cons, Fidencio, additional, Gilchrist, Nigel Leslie, additional, Reid, Ian Reginald, additional, Leikis, Robert, additional, Jones, Peter, additional, Singh, Joe Gragrath Pradeep, additional, Halse, Johan Inge, additional, Syversen, Unni, additional, Høivik, Hans Olav, additional, Øfjord, Erik Snorre, additional, Gulseth, Hans Christian, additional, Elle, Sigbjørn, additional, Norheim, Paal Dag, additional, Calvo Quiroz, Armando A., additional, Cesar Augusto, Pastor A., additional, León Portocarrero, Manuel Gustavo, additional, Vidal Neira, Luis Fernando, additional, Chavez, Jose, additional, Garro Barrera, Boris, additional, Kuroiwa Sampei, Rita, additional, Luis Fernando, Bellatín V., additional, Oquelis Cabredo, Rogger, additional, Castillo, Sonia, additional, Morales, Agustin Miguel G, additional, Tan, Perry Pua, additional, Leagogo, Liberato Antonio C, additional, Wang, Edward HM, additional, Li-Yu, Julie T, additional, Sawicki, Andrzej Z, additional, Stasiuk, Barbara, additional, Kania, Grzegorz, additional, Lorenc, Roman, additional, Sidorowicz-Bialynicka, Anna, additional, Szczepanski, Leszek, additional, Franek, Edward, additional, Filip, Rafal, additional, Sekula, Jan, additional, Blicharski, Tomasz, additional, Leszczynski, Piotr, additional, Sewerynek, Ewa, additional, Miazgowski, Tomasz, additional, Milewicz, Andrzej, additional, Dabrowska, Magda, additional, Romaszko, Jerzy, additional, Pluskiewicz, Wojciech, additional, Wojnowski, Lukasz, additional, Codreanu, Catalin, additional, Bolosiu, Horatiu, additional, Ionescu, Ruxandra, additional, Zosin, Ioana, additional, Macovei, Liviu, additional, Bojinca, Mihai, additional, Radulescu, Florin, additional, Pop, Simona, additional, Sarbu, Adrian, additional, Benevolenskaya, Lidia I, additional, Nasonov, Evgeny L, additional, Rozhinskaya, Lyudmila Ya, additional, Oganov, Raphael G, additional, Rodionova, Svetlana S, additional, Shlyakhto, Eugeny Vladimirovich, additional, Trofimov, Vasiliy, additional, Zotkin, Eugeny G, additional, Zazerskaya, Irina E, additional, Grineva, Elena N, additional, Ershova, Olga, additional, Lesnyak, Olga, additional, Ostroumova, Olga D, additional, Malichenko, Svetlana B, additional, Pikhlak, Eduard G, additional, Pilyaev, Valery G, additional, Raskina, Tatiana, additional, Zonova, Elena V, additional, Shirinsky, Valery S, additional, Dimic, Aleksandar N, additional, Cobeljic, Goran, additional, Vujovic, Svetlana, additional, Ellis, Graham Charlston, additional, Lipschitz, Stanley, additional, De Villiers, Tobias Johannes, additional, De Weerd, Albert Jan, additional, Vally, Tasneem, additional, Trinder, Yvonne, additional, Coetsee, Jacobus Ludewikus, additional, Davis, Charles Pierre, additional, Nayiager, Savithree, additional, Hough, Frans Stephanus, additional, Oelofse, Louis F, additional, van der Walt, Eugene, additional, Lombaard, Johannes Jurgens, additional, Blignaut, Suzanne, additional, Govind, Uttam, additional, Fouche, Leon Frederik, additional, Kruger, Dawid Stephanus, additional, Dalmeyer, Johannes Paul, additional, Ferreira, Mada M, additional, Escudero-Contreras, Alejandro, additional, Muñoz Torres, Manuel, additional, Hawkins Carranza, Federico, additional, Perez Castrillon, Jose Luis, additional, García Meijide, Juan Antonio, additional, Jodar Gimeno, Esteban, additional, Palacios Gil-Antuñana, Santiago, additional, de Teresa Parreno, Luis, additional, Martín Mola, Emilio, additional, Alvarez Sanchez, Carmen, additional, Tsai, Keh-Sung, additional, Tu, Shih-Te, additional, Chen, Jung-Fu, additional, Lee, Oscar Kuang-Sheng, additional, Hsu, Wen-Wei, additional, Grygorieva, Natalia Viktorivna, additional, Povoroznyuk, Vladyslav Volodymyrovych, additional, Korzh, Mykola Oleksiiovych, additional, Loskutov, Oleksandr Levgeniiovych, additional, Chukov, Andriy Borysovych, additional, Sarmiento, Rex, additional, Thomas, Hawys, additional, Donnachie, Hugh, additional, Pavel-Knox, Irina, additional, Shaw, Hilary, additional, Hassanin, Hana, additional, Abdulhakim, Essam Eldin Ahmed, additional, Savani, Naren, additional, Bachmann, Gloria A, additional, Barrett-Connor, Elizabeth, additional, Binkley, Neil C, additional, Bone, Henry G, additional, Brandon, Donald M, additional, Checketts, Darin David, additional, Fraser, Neil J, additional, Watts, Nelson B, additional, Geller, Steven A, additional, Gimbel, Joseph S, additional, Greenwald, Maria White, additional, Holt, Peter A, additional, Johnston, Cyrus Conrad, additional, Fang, Chien, additional, Klashman, David J, additional, Lewiecki, E. Michael, additional, Lowenstein, Mitchell B, additional, McClung, Michael Roy, additional, Nattrass, Susan M, additional, Odio, Alberto, additional, Levengood, Julie, additional, Romaguera, Josefina, additional, Sebai, Mohamed Bassam, additional, Snyder, Brian, additional, Kutner, Mark Eliot, additional, Streja, Dan, additional, Schwartz, Elliott P, additional, and Christiansen, Mark G, additional

Published
2019
Full Text
View/download PDF

25. Cogan's syndrome in patients with inflammatory bowel disease--a case series

Author

Vavricka, Stephan R, Greuter, Thomas, Scharl, Michael, Mantzaris, Gerassimos, Shitrit, Ariella B, Filip, Rafal, Karmiris, Konstantinos, Thoeringer, Christoph K, Boldys, Hubert, Wewer, Anne V, Yanai, Henit, Flores, Cristina, Schmidt, Carsten, Kariv, Revital, Rogler, Gerhard, Rahier, Jean-François, and University of Zurich

Subjects
10219 Clinic for Gastroenterology and Hepatology, 610 Medicine & health, 2715 Gastroenterology
Published
2015
Full Text
View/download PDF

28. A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial to Evaluate the Efficacy, Safety, and Tolerability of Prucalopride in Men With Chronic Constipation

Author

Yiannakou, Yan, primary, Piessevaux, Hubert, additional, Bouchoucha, Michel, additional, Schiefke, Ingolf, additional, Filip, Rafal, additional, Gabalec, Libor, additional, Dina, Ion, additional, Stephenson, David, additional, Kerstens, René, additional, Etherson, Kevin, additional, and Levine, Amy, additional

Published
2015
Full Text
View/download PDF

30. Dietary supplementation with phytohemagglutinin in combination with a-ketoglutarate limits the excretion of nitrogen via urinary tract

Author

Filip, Rafal, Wdowiak, Leszek, Harrison, Adrian Paul, Pierzynowski, Stefan G., Filip, Rafal, Wdowiak, Leszek, Harrison, Adrian Paul, and Pierzynowski, Stefan G.

Abstract

The aim of the study was to evaluate the effect of both phytohaemagglutinin (PHA) alone, and in combination with alpha-ketoglutaric acid (AKG), on nitrogen elimination via the urinary tract as opposed to the gastrointestinal tract of rats. In experiment 1, rats were assigned to one of two experimental groups, (1) Control and (2) PHA, whilst in experiment 2, rats were assigned to one of three experimental groups, (1) Control, (2) AKG, and (3) AKG+PHA. AKG was administered via drinking water, while PHA was administered via a stomach tube. The stock solution of crude PHA in 0.9% NaCl, was (20% w/v) in water: 50 mg PHA/ml, 20 ml/kg body wt. Rats were 7 weeks old at the start of the experiments. Significantly lower daily weight gains in the AKG+PHA and PHA groups (p<0.05) were observed compared to the Control and AKG groups. Increased duodenal crypt depth (138%; p<0.05) was noticeable in the AKG+PHA group of Controls; however, there was no significant difference in the thickness of the tunica mucosa. In the AKG+PHA group, the expression of neuropeptide Y (NPY) in the granula of neuronal cells of the submucosal parasympathetic ganglia was noticeable, although no expression was found in goblet cells. Finally, significant reduction in N excretion in urine was observed in the AKG+PHA, compared with the Control Groups (p<0.05). It is concluded that a combined PHA and AKG treatment stimulated the small bowel growth via enhanced epithelial turnover, reduced the N excreted in urine and increased the N in feces.

Published
2008

31. Effect of feed supplementation with a-ketoglutarate, combined with vitamin B6 or C, on the performance and haemoglobin and amino acid levels in growing rats

Author

Pierzynowski, Stefan Grzegorz, Filip, Rafal, Harrison, Adrian Paul, Pierzynowski, Stefan Grzegorz, Filip, Rafal, and Harrison, Adrian Paul

Abstract

The aim of the study was to evaluate the influence of a-ketoglutarate (AKG), at pH 2 or 5, combined with vitamin B6 (AKG 2B, AKG 5B) or C (AKG 2C, AKG 5C), on the performance and haemoglobin and amino acid levels in growing rats. Eighty rats were divided into 5 treatment groups and stayed on trial for 9 d (n=16) or 18 d (n=10). No significant differences in average daily gain (ADG), average daily feed intake (ADFI), or feed efficiency were seen between the dextrose-treated control group and the AKG treated groups. The highest ADG and ADFI were seen in the AKG 2B rats. The AKG 2B and AKG 2C treated rats had the highest Hb levels. The Hb levels were positively correlated with a better performance. The free glutamine (Glu) increased over time in all the groups. The arginine (Arg) levels significantly increased in the AKG 2B and AKG 5B groups. An increase in free Glu had a positive impact on the growth performance.

Published
2007

32. Cogan's Syndrome in Patients With Inflammatory Bowel Disease - A Case Series.

Author

Vavricka, Stephan R., Greuter, Thomas, Scharl, Michael, Mantzaris, Gerassimos, Shitrit, Ariella B., Filip, Rafal, Karmiris, Konstantinos, Thoeringer, Christoph K., Boldys, Hubert, Wewer, Anne V., Yanai, Henit, Flores, Cristina, Schmidt, Carsten, Kariv, Revital, Rogler, Gerhard, and Rahier, Jean-François

Abstract

Background: Cogan's syndrome (CSy) is a very rare autoimmune disorder, mainly affecting the inner ear and the eye, and is associated with inflammatory bowel disease (IBD). Methods: This was a European Crohn's and Colitis Organisation (ECCO) retrospective observational study, performed as part of the CONFER project. A call to all ECCO members was made to report concomitant CSy and inflammatory bowel disease (IBD) cases. Clinical data were recorded in a standardized questionnaire. Results: This international case series reports on 22 concomitant CSy-IBD cases from 14 large medical centres. Mean duration of IBD until diagnosis of CSy was 8.7 years (range 0.0-38.0) and mean age at CSy diagnosis was 44.6 years (range 9.0-67.0). Six patients had underlying ulcerative colitis (UC) and 16 had Crohn's disease. Eleven patients (50%) had active disease at CSy diagnosis. Sixteen patients were under IBD treatment at the time of CSy diagnosis, of whom 6 (37.5%) were on anti-tumour necrosis factor (TNF). Seven out of 10 patients, who were treated for CSy with immunomodulators (mostly with corticosteroids), demonstrated at least partial response. Conclusion: This is the largest CSy-IBD case series so far. Although CSy is considered to be an autoimmune disease and is associated with IBD, immunomodulatory IBD maintenance treatment and even anti-TNF therapy do not seem to prevent disease onset. Moreover, IBD disease activity does not seem to trigger CSy. However, vigilance may prompt early diagnosis and directed intervention with corticosteroids at inception may potentially hinder audiovestibular deterioration. Finally, vigilance and awareness may also offer a better setting to study the pathophysiological mechanisms of this rare but debilitating phenomenon. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

34. Common drug switching during long-term antiresorptive treatment: experience of four osteoporosis centers in Poland (2001–2005)

Author

Franek, Edward, Talalaj, Marek, Wichrowska, Hanna, Czerwienska, Beata, Filip, Rafal, Safranow, Krzysztof, Marcinowska-Suchowierska, Ewa, and Wiecek, Andrzej

Abstract

Background and aims:In clinical trials, the most frequent reasons for treatment discontinuation are adverse events and personal conflicts with medical staff. However, in ‘real life’, i.e. not in the frame of a controlled and monitored trial, other reasons are also possible, when not only discontinuation, but also switching of treatment happens. The aim of this study was to estimate how often and why persistent osteoporosis patients switch from one treatment to another. Methods:A retrospective analysis of 1314 ambulatory treated persistent osteoporosis patients was performed (1180 F, 134 M, mean age±SD: 66.5±10 yrs, BMI 26.4±4.2 kg/m2). Drugs used for osteoporosis, duration of treatment, frequency and reasons for drug switching were all analyzed. Results:In 530 (40.3%) patients, treatment was not changed during the observation period (16.1±9.1 months). In 784 (59.7%) patients at least one drug switch happened, and the total number of switches was 1117 (1–5 switches/patient). The mean time of observation in this group was 22.3±14.9 months. The most frequent reasons for drug switching were: adverse event (34.6% of all switches), high price of the drug (28.7%) and ineffective treatment (13.3%). Conclusions:In almost 60% of the persistent patients, at least one switch of antiosteoporotic treatment occurred in the nearly 2-year observation period. The most frequent reasons for drug switching were adverse reactions, the high price of the drug, and ineffective treatment.

Published
2008
Full Text
View/download PDF

36. Cellular uptake of soy-derived phytoestrogens in vitro and in human whole blood

Author

Maubach, Julie, Bracke, Marc, Depypere, Herman, De Keukeleire, Denis, Heyerick, Arne, Filip, Rafal, Studzinski, Tadeusz, and Wdowiak, Leszek

Subjects
genistein, phytoestrogens, endocrine system, soy, Medicine and Health Sciences, food and beverages, cellular uptake, daidzein, biodistribution, equol
Abstract

Epidemiological studies comparing typical Western and traditional Eastern lifestyles indicate that dietary intake of soyderived phytoestrogens, including genistein, daidzein, and equol, may have significant health protective effects on hormone-dependent cancers, osteoporosis and cardiovascular diseases. Phytoestrogens have been demonstrated to exert varying effects depending on tissue, endogenous hormone concentrations, and receptor types. Thus, a detailed understanding of the biodistribution and bioavailability of specific phytoestrogens is required in order to predict the subsequent biologic activities. In this study we aimed to investigate the cellular uptake of these soy-derived phytoestrogens in different cell types, including the mammary MCF-7/6 and MDAB-MB 231 cell lines, the ovarian Ishikawa Var-I cell lines and in murine adipocyte clusters. Furthermore, the biodistribution between serum and cell fraction was also investigated in human whole blood. Equol generally shows a higher cellular uptake when compared with genistein and daidzein. Therefore, equol may be more potent with respect to its relative bioactivity, which is corroborated by the observations of specific health effects associated with the equol-producer phenotype.

Published
2008

37. Gastroenteropancreatic Neuroendocrine Neoplasms in Patients with Inflammatory Bowel Disease: An ECCO CONFER Multicentre Case Series.

Author

Festa S, Zerboni G, Derikx LAAP, Ribaldone DG, Dragoni G, Buskens C, van Dijkum EN, Pugliese D, Panzuto F, Krela-Kaźmierczak I, Mintz HR, Shitrit AB, Chaparro M, Gisbert JP, Kopylov U, Teich N, Vainer E, Nagtegaal I, Hoentjen F, Garcia MJ, Filip R, Foteinogiannopoulou K, Koutroubakis IE, Argollo M, van Wanrooij RLJ, Laja H, Lobaton T, Truyens M, Molnar T, Savarino E, Aratari A, Papi C, and Goren I

Subjects
Female, Humans, Male, Middle Aged, Inflammatory Bowel Diseases complications, Intestinal Neoplasms epidemiology, Intestinal Neoplasms etiology, Neuroendocrine Tumors complications, Neuroendocrine Tumors epidemiology, Neuroendocrine Tumors therapy, Pancreatic Neoplasms epidemiology, Pancreatic Neoplasms etiology, Pancreatic Neoplasms therapy, Stomach Neoplasms epidemiology, Stomach Neoplasms etiology, Stomach Neoplasms therapy
Abstract

Background: Gastroenteropancreatic neuroendocrine neoplasms [GEP-NENs] have rarely been reported in association with inflammatory bowel diseases [IBDs]., Methods: An ECCO COllaborative Network For Exceptionally Rare case reports project [ECCO-CONFER] collects cases of GEP-NENs diagnosed in patients with IBD., Results: GEP-NEN was diagnosed in 100 IBD patients; 61% female, 55% Crohn's disease, median age 48 years (interquartile range [IQR] 38-59]). The most common location was the appendix [39%] followed by the colon [22%]. Comprehensive IBD-related data were available for 50 individuals with a median follow-up of 30 months [IQR 11-70] following NEN diagnosis. Median duration of IBD at NEN diagnosis was 84 months [IQR 10-151], and in 18% of cases NEN and IBD were diagnosed concomitantly. At diagnosis, 20/50 were stage-I [T1N0M0], and 28/50 were graded G1 [ki67 ≤2%]. Incidental diagnosis of NEN and concomitantly IBD diagnosis were associated with an earlier NEN stage [p = 0.01 and p = 0.02, respectively]. Exposure to immunomodulatory or biologic therapy was not associated with advanced NEN stage or grade. Primary GEP-NEN were more frequently found in the segment affected by IBD [62% vs 38%]. At the last follow-up data, 47/50 patients were alive, and only two deaths were related to NEN., Conclusions: In the largest case series to date, prognosis of patients with GEP-NEN and IBD seems favourable. Incidental NEN diagnosis correlates with an earlier NEN stage, and IBD-related therapies are probably independent of NEN stage and grade. The association of GEP-NEN location and the segment affected by IBD may suggest a possible role of inflammation in NEN tumorigenesis., (© The Author(s) 2021. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Published
2022
Full Text
View/download PDF

38. State of patients' knowledge about treatment and proceedings in type 2 diabetes.

Author

Filip R, Lewandowska A, Szczepankiewicz M, and Majda B

Subjects
Adult, Aged, Aged, 80 and over, Diabetes Mellitus, Type 2 prevention & control, Female, Humans, Male, Middle Aged, Poland, Surveys and Questionnaires, Diabetes Mellitus, Type 2 psychology, Diabetes Mellitus, Type 2 therapy, Health Knowledge, Attitudes, Practice
Abstract

Objective: The aim of the research was to evaluate the level of patients' knowledge about type 2 diabetes, treatment and proceedings in the case of the disease., Materials and Method: 100 patients suffering from type 2 diabetes were included in the research, aged 40-90 years (64% and 36%), who lived in the countryside (54%) and in the city (46%), hospitalized in the internal and geriatric wards in provincial hospitals of the Podkarpacie Region in south-eastern Poland. The research method was a diagnostic survey conducted by use of a questionnaire that consisted of 31 both multiple choice and open questions. Among the respondents, 64% were women and 36% men. Among them, 18% were aged from 40-50, 20% aged from 51-60, 28% from 61-70, 24% from 71-80-years-old, and 10% of respondents were aged over 80. Among the examined, 12% were treated only by diet, 24% by insulin, 18% by insulin and diet., Results: From among respondents cured by insulin, 52% of them administered their own injections, 36% had the injections administered by a family member, and 12% had the injections administered by a nurse. From among the patients, 70% knew the symptoms of hypo- and hyperglycaemia, 84% knew how to react in the case of hypoglycaemia, but only 56% knew how to react in the case of hyperglycaemia. From among respondents, 68% controlled the skin if the feet., Conclusions: Over a half of the respondents (70%) know the symptoms of diabetes and mentioned frequent urination (77%) and increased thirst (65%), but 30% had no knowledge of the symptoms of diabetes. The state of the patients' knowledge about different complications of the disease was in insufficient.

Published
2014
Full Text
View/download PDF

39. Bone mineral density and bone turnover in relation to serum leptin, alpha-ketoglutarate and sex steroids in overweight and obese postmenopausal women.

Author

Filip R and Raszewski G

Subjects
Absorptiometry, Photon, Aged, Dehydroepiandrosterone Sulfate blood, Estrogens blood, Female, Femur Neck physiology, Humans, Lumbar Vertebrae physiology, Middle Aged, Obesity physiopathology, Overweight physiopathology, Sex Hormone-Binding Globulin metabolism, Testosterone blood, Bone Density physiology, Bone and Bones metabolism, Gonadal Steroid Hormones blood, Ketoglutaric Acids blood, Leptin blood, Obesity metabolism, Overweight metabolism, Postmenopause metabolism
Abstract

Objective: Recent studies have shown that parallel changes in body weight and bone mass can be partially mediated via circulating leptin. Therefore, among the hormones involved in bone and mineral metabolism, such as oestrogens, testosterone and parathormone, leptin has recently become a subject of considerable interest. The aim of this study was to assess associations between leptin, E(2), testosterone, dehydroepiandrosterone sulphate (DHEA-S), SHBG, alpha-ketoglutaric acid (AKG) and bone mineral density (BMD) and bone turnover markers in overweight and obese postmenopausal women., Design: Eighty healthy, postmenopausal Caucasian women were studied. BMD of the lumbar spine (L(2)-L(4)) and femoral neck regions were examined using the dual X-ray absorptiometry (DXA) method. Associations were evaluated in stepwise multiple regression analysis, including information on the possible confounders and effect modifiers, for example, age, years since menopause, height and weight., Results: Femoral neck BMD was positively correlated with weight (r = 0.52, P < 0.000001), body mass index (BMI) (r = 0.48, P < 0.000006), hipline (r = 0.48, P < 0.00006), waistline (r = 0.45, P < 0.00002) and DHEA-S (r = 0.36, P < 0.0008). Correlations of E(2), SHBG, testosterone and leptin, as well as biochemical markers of bone turnover with L(2)-L(4) and femoral neck BMD were not found. In the whole study group, significant predictors of L(2)-L(4 )BMD were BMI (beta = 0.35, P < 0.01) testosterone (beta = 0.27, P < 0.05) and osteocalcin (OC) (beta = 0.22, P < 0.05) (R(2) = 0.23), while predictors of femoral neck BMD were BMI (beta = 0.42, P < 0.001), testosterone (beta = 0.24, P < 0.05), E(2) (beta = 0.19, P < 0.05), as well as osteocalcin (beta = 0.20, P < 0.05) (R(2) = 0.41). In the subgroup with BMI 30-39.9, the significant predictors of both L(2)-L(4 )and femoral neck BMD were testosterone (beta = 0.32, P < 0.05, R(2) = 0.19; beta = 0.33, P < 0.05, R(2) = 0.29) and osteocalcin (beta = 0.34, P < 0.05, R(2) = 0.19; beta = 0.45, P < 0.01, R(2) = 0.29). In the subgroup with waist : hip ratio (WHR > or = 0.85, the predictor of L(2)-L(4 )BMD was E(2) (beta = 0.38, P < 0.05) (R(2) = 0.21), whereas the predictors of femoral neck BMD were BMI (beta = 0.29, P < 0.05) and testosterone (beta = 0.35, P < 0.01) (R(2) = 0.36)., Conclusion: The main endocrine variable predicting lumbar spine BMD in overweight and obese postmenopausal females was testosterone, while the main determinants of femoral neck BMD were both testosterone and E(2). No effect was found of serum leptin on examined indicators of bone status.

Published
2009
Full Text
View/download PDF

40. [Use of oximes in the therapy of acute intoxication by organophosphorus compounds].

Author

Raszewski G and Filip R

Subjects
Anticonvulsants therapeutic use, Atropine therapeutic use, Cholinesterase Inhibitors poisoning, Cholinesterase Reactivators pharmacology, Diazepam therapeutic use, Humans, Muscarinic Antagonists therapeutic use, Organophosphorus Compounds pharmacology, Poisoning metabolism, Risk Factors, Cholinesterase Reactivators therapeutic use, Organophosphate Poisoning, Oximes therapeutic use, Poisoning drug therapy
Abstract

The treatment of patients who consumed lethal doses of various organophosphorus compounds (OP) still remains a great challenge to clinical toxicologists. The oximes in combination with atropine and diazepam are an integral part of the treatment of acute intoxications with organophosphate. Treatment with atropine, which relieves the muscarinic effects of acetylcholine and anticonvulsive agents (diazepam) is well established. However, the effectiveness of oxime compounds in counteracting the effect of intoxication in still a matter of debate. Based on literature reports, opinions are presented concerning the role of oximes in the treatment of intoxications by various OP.

Published
2004

Catalog

Books, media, physical & digital resources
See catalog results