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7. Lower Dopamine D2 Receptor Expression Levels in Human Dopaminergic Neurons Derived From Opioid-Dependent iPSCs.

Author

Yang Sheng, Filichia, Emily, Shick, Elizabeth, Preston, Kenzie L., Phillips, Karran A., Cooperman, Leslie, Zhicheng Lin, Tesar, Paul, Hoffer, Barry J., and Yu Luo

Subjects
*RNA metabolism, *CELL receptors, *NEURONS, *POLYMERASE chain reaction, *STEM cells, *SUBSTANCE abuse, *CASE-control method, *REVERSE transcriptase polymerase chain reaction
Abstract

The article focuses on the study that shows the decreased expression level of dopamine D2 receptors in human dopaminergic neurons generated from opioid-dependent induced pluripotent stem cells (iPSCs). It provides brief overview of the method of the study in which the dopaminergic neurons were derived from drug-dependent individuals. The result of the study suggests that human iPSC-derived dopamine neurons may serve as a useful model to investigate human dopamine neurons.

Published
2016
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8. Lower Dopamine D2 Receptor Expression Levels in Human Dopaminergic Neurons Derived From Opioid-Dependent iPSCs.

Author

Sheng Y, Filichia E, Shick E, Preston KL, Phillips KA, Cooperman L, Lin Z, Tesar P, Hoffer BJ, and Luo Y

Subjects
Case-Control Studies, Dopaminergic Neurons cytology, Humans, Induced Pluripotent Stem Cells cytology, Receptors, Opioid, mu genetics, Reverse Transcriptase Polymerase Chain Reaction, Dopaminergic Neurons metabolism, Induced Pluripotent Stem Cells metabolism, Opioid-Related Disorders genetics, RNA, Messenger metabolism, Receptors, Dopamine D2 genetics
Published
2016
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