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355 results on '"Filhol, Odile"'

1. GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway

Author

Park, Ann Y., Leney-Greene, Michael, Lynberg, Matthew, Gabrielski, Justin Q., Xu, Xijin, Schwarz, Benjamin, Zheng, Lixin, Balasubramaniyam, Arasu, Ham, Hyoungjun, Chao, Brittany, Zhang, Yu, Matthews, Helen F., Cui, Jing, Yao, Yikun, Kubo, Satoshi, Chanchu, Jean Michel, Morawski, Aaron R., Cook, Sarah A., Jiang, Ping, Ravell, Juan C., Cheng, Yan H., George, Alex, Faruqi, Aiman, Pagalilauan, Alison M., Bergerson, Jenna R. E., Ganesan, Sundar, Chauvin, Samuel D., Aluri, Jahnavi, Edwards-Hicks, Joy, Bohrnsen, Eric, Tippett, Caroline, Omar, Habib, Xu, Leilei, Butcher, Geoffrey W., Pascall, John, Karakoc-Aydiner, Elif, Kiykim, Ayca, Maecker, Holden, Tezcan, İlhan, Esenboga, Saliha, Heredia, Raul Jimenez, Akata, Deniz, Tekin, Saban, Kara, Altan, Kuloglu, Zarife, Unal, Emel, Kendirli, Tanıl, Dogu, Figen, Karabiber, Esra, Atkinson, T. Prescott, Cochet, Claude, Filhol, Odile, Bosio, Catherine M., Davis, Mark M., Lifton, Richard P., Pearce, Erika L., Daumke, Oliver, Aytekin, Caner, Şahin, Gülseren Evirgen, Aksu, Aysel Ünlüsoy, Uzel, Gulbu, Koneti Rao, V., Sari, Sinan, Dalgıç, Buket, Boztug, Kaan, Cagdas, Deniz, Haskologlu, Sule, Ikinciogullari, Aydan, Schwefel, David, Vilarinho, Silvia, Baris, Safa, Ozen, Ahmet, Su, Helen C., and Lenardo, Michael J.

Published
2024
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2. Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway

Author

Park, Ann Y., Leney-Greene, Michael, Lynberg, Matthew, Gabrielski, Justin Q., Xu, Xijin, Schwarz, Benjamin, Zheng, Lixin, Balasubramaniyam, Arasu, Ham, Hyoungjun, Chao, Brittany, Zhang, Yu, Matthews, Helen F., Cui, Jing, Yao, Yikun, Kubo, Satoshi, Chanchu, Jean Michel, Morawski, Aaron R., Cook, Sarah A., Jiang, Ping, Ravell, Juan C., Cheng, Yan H., George, Alex, Faruqi, Aiman, Pagalilauan, Alison M., Bergerson, Jenna R. E., Ganesan, Sundar, Chauvin, Samuel D., Aluri, Jahnavi, Edwards-Hicks, Joy, Bohrnsen, Eric, Tippett, Caroline, Omar, Habib, Xu, Leilei, Butcher, Geoffrey W., Pascall, John, Karakoc-Aydiner, Elif, Kiykim, Ayca, Maecker, Holden, Tezcan, İlhan, Esenboga, Saliha, Heredia, Raul Jimenez, Akata, Deniz, Tekin, Saban, Kara, Altan, Kuloglu, Zarife, Unal, Emel, Kendirli, Tanıl, Dogu, Figen, Karabiber, Esra, Atkinson, T. Prescott, Cochet, Claude, Filhol, Odile, Bosio, Catherine M., Davis, Mark M., Lifton, Richard P., Pearce, Erika L., Daumke, Oliver, Aytekin, Caner, Şahin, Gülseren Evirgen, Aksu, Aysel Ünlüsoy, Uzel, Gulbu, Koneti Rao, V., Sari, Sinan, Dalgıç, Buket, Boztug, Kaan, Cagdas, Deniz, Haskologlu, Sule, Ikinciogullari, Aydan, Schwefel, David, Vilarinho, Silvia, Baris, Safa, Ozen, Ahmet, Su, Helen C., and Lenardo, Michael J.

Published
2024
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6. Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors.

Author

Kufareva, Irina, Bestgen, Benoit, Brear, Paul, Prudent, Renaud, Laudet, Béatrice, Moucadel, Virginie, Ettaoussi, Mohamed, Sautel, Celine F, Krimm, Isabelle, Engel, Matthias, Filhol, Odile, Borgne, Marc Le, Lomberget, Thierry, Cochet, Claude, and Abagyan, Ruben

Abstract

CK2 is a constitutively active protein kinase overexpressed in numerous malignancies. Interaction between CK2α and CK2β subunits is essential for substrate selectivity. The CK2α/CK2β interface has been previously targeted by peptides to achieve functional effects; however, no small molecules modulators were identified due to pocket flexibility and open shape. Here we generated numerous plausible conformations of the interface using the fumigation modeling protocol, and virtually screened a compound library to discover compound 1 that suppressed CK2α/CK2β interaction in vitro and inhibited CK2 in a substrate-selective manner. Orthogonal SPR, crystallography, and NMR experiments demonstrated that 4 and 6, improved analogs of 1, bind to CK2α as predicted. Both inhibitors alter CK2 activity in cells through inhibition of CK2 holoenzyme formation. Treatment with 6 suppressed MDA-MB231 triple negative breast cancer cell growth and induced apoptosis. Altogether, our findings exemplify an innovative computational-experimental approach and identify novel non-peptidic inhibitors of CK2 subunit interface disclosing substrate-selective functional effects.

Published
2019

7. 2‑Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action

Author

Bestgen, Benoît, Kufareva, Irina, Seetoh, Weiguang, Abell, Chris, Hartmann, Rolf W, Abagyan, Ruben, Le Borgne, Marc, Filhol, Odile, Cochet, Claude, Lomberget, Thierry, and Engel, Matthias

Subjects
Medicinal and Biomolecular Chemistry, Chemical Sciences, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Allosteric Regulation, Allosteric Site, Antineoplastic Agents, Apoptosis, Benzoates, Casein Kinase II, Cell Line, Tumor, Humans, Ligands, Molecular Docking Simulation, Molecular Structure, Naphthyridines, Phenazines, Prodrugs, Protein Binding, Protein Kinase Inhibitors, Structure-Activity Relationship, Thiazoles, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry, Pharmacology and pharmaceutical sciences, Medicinal and biomolecular chemistry, Organic chemistry
Abstract

Protein CK2 has gained much interest as an anticancer drug target in the past decade. We had previously described the identification of a new allosteric site on the catalytic α-subunit, along with first small molecule ligands based on the 4-(4-phenylthiazol-2-ylamino)benzoic acid scaffold. In the present work, structure optimizations guided by a binding model led to the identification of the lead compound 2-hydroxy-4-((4-(naphthalen-2-yl)thiazol-2-yl)amino)benzoic acid (27), showing a submicromolar potency against purified CK2α (IC50 = 0.6 μM). Furthermore, 27 induced apoptosis and cell death in 786-O renal cell carcinoma cells (EC50 = 5 μM) and inhibited STAT3 activation even more potently than the ATP-competitive drug candidate CX-4945 (EC50 of 1.6 μM vs 5.3 μM). Notably, the potencies of our allosteric ligands to inhibit CK2 varied depending on the individual substrate. Altogether, the novel allosteric pocket was proved a druggable site, offering an excellent perspective to develop efficient and selective allosteric CK2 inhibitors.

Published
2019

9. New players in the landscape of renal cell carcinoma bone metastasis and therapeutic opportunities.

Author

Cesana, Beatrice, Cochet, Claude, and Filhol, Odile

Abstract

Approximately one‐third of advanced renal cell carcinoma (RCC) patients develop osteolytic bone metastases, leading to skeletal complications. In this review, we first provide a comprehensive perspective of seminal studies on bone metastasis of RCC describing the main molecular modulators and growth factor signaling pathways most important for the RCC‐stimulated osteoclast‐mediated bone destruction. We next focus on newer developments revealing with in‐depth details, the bidirectional interplay between renal cancer cells and the immune and stromal microenvironment that can through epigenetic reprogramming, profoundly affect the behaviors of transformed cells. Understanding their mechanistic interactions is of paramount importance for advancing both fundamental and translational research. These new investigations into the landscape of RCC‐bone metastasis offer novel insights and identify potential avenues for future therapeutic interventions. [ABSTRACT FROM AUTHOR]

Published
2025
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12. CK2β Regulates Hematopoietic Stem Cell Biology and Erythropoiesis

Author

Quotti Tubi, Laura, primary, Canovas Nunes, Sara, additional, Mandato, Elisa, additional, Pizzi, Marco, additional, Vitulo, Nicola, additional, D’Agnolo, Mirco, additional, Colombatti, Raffaella, additional, Martella, Maddalena, additional, Boaro, Maria Paola, additional, Doriguzzi Breatta, Elena, additional, Fregnani, Anna, additional, Spinello, Zaira, additional, Nabergoj, Mitja, additional, Filhol, Odile, additional, Boldyreff, Brigitte, additional, Albiero, Mattia, additional, Fadini, Gian Paolo, additional, Gurrieri, Carmela, additional, Vianello, Fabrizio, additional, Semenzato, Gianpietro, additional, Manni, Sabrina, additional, Trentin, Livio, additional, and Piazza, Francesco, additional

Published
2023
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13. Intracellular Fate of Sub-Toxic Concentration of Functionalized Selenium Nanoparticles in Aggressive Prostate Cancer Cells

Author

Bissardon, Caroline, primary, Proux, Olivier, additional, Gazze, Salvatore Andrea, additional, Filhol, Odile, additional, Toubhans, Benoît, additional, Sauzéat, Lucie, additional, Bouchet, Sylvain, additional, Lewis, Aled R., additional, Maffeis, Thierry, additional, Hazemann, Jean-Louis, additional, Bayat, Sam, additional, Cloetens, Peter, additional, Conlan, R. Steven, additional, Charlet, Laurent, additional, and Bohic, Sylvain, additional

Published
2023
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15. Microenvironment of metastatic site reveals key predictors of PD-1 blockade response in renal cell carcinoma

Author

Jeanneret, Florian, primary, Bazelle, Pauline, additional, Schoch, Sarah, additional, Pillet, Catherine, additional, Um, In Hwa, additional, Bouzit, Assilah, additional, Evrard, Bertrand, additional, Seffar, Evan, additional, Chalmel, Frederic, additional, Alfaro, Javier A, additional, Pesquita, Catia, additional, Zanzotto, Fabio Massimo, additional, Stares, Mark, additional, Symeonides, Stefan N, additional, Laird, Alexander, additional, Long, Jean-Alexandre, additional, Descotes, Jean Luc, additional, Pflieger, Delphine, additional, Harrison, David J, additional, Filhol, Odile, additional, Axelson, Hakan, additional, and Battail, Christophe, additional

Published
2023
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17. Dysregulated Expression of Protein Kinase CK2 in Renal Cancer

Author

Roelants, Caroline, Giacosa, Sofia, Duchemin-Pelletier, Eve, McLeer-Florin, Anne, Tisseyre, Céline, Aubert, Cédric, Champelovier, Pierre, Boutonnat, Jean, Descotes, Jean Luc, Rambeaud, Jean-Jacques, Arnoux, Valentin, Long, Jean-Alexandre, Pasquier, Dominique, Laramas, Mathieu, Kassem, Maysoun, David-Boudet, Laurence, Schoutteten, Laure, Bestgen, Benoit, Pillet, Catherine, Cochet, Claude, Filhol, Odile, Dhalla, Naranjan S., Series editor, Ahmed, Khalil, editor, Issinger, Olaf-Georg, editor, and Szyszka, Ryszard, editor

Published
2015
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18. The tyrosine-kinase inhibitor sunitinib targets vascular endothelial (VE)-cadherin: a marker of response to antitumoural treatment in metastatic renal cell carcinoma

Author

Polena, Helena, Creuzet, Julie, Dufies, Maeva, Sidibé, Adama, Khalil-Mgharbel, Abir, Salomon, Aude, Deroux, Alban, Quesada, Jean-Louis, Roelants, Caroline, Filhol, Odile, Cochet, Claude, Blanc, Ellen, Ferlay-Segura, Céline, Borchiellini, Delphine, Ferrero, Jean-Marc, Escudier, Bernard, Négrier, Sylvie, Pages, Gilles, and Vilgrain, Isabelle

Published
2018
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20. A new scaffold-free tumoroid model provides a robust preclinical tool to investigate invasion and drug response in Renal Cell Carcinoma

Author

Filhol, Odile, primary, Séraudie, Irinka, additional, Pillet, Catherine, additional, Cesana, Beatrice, additional, Bazelle, Pauline, additional, Jeanneret, Florian, additional, Evrard, Bertrand, additional, Chalmel, Frederic, additional, Bouzit, Assilah, additional, Long, Jean-Alexandre, additional, Descotes, Jean-Luc, additional, Cochet, Claude, additional, and Battail, Christophe, additional

Published
2023
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21. Supplementary Legends for Figures and Tables, Methods from Antitumor Activity of Pyridocarbazole and Benzopyridoindole Derivatives that Inhibit Protein Kinase CK2

Author

Prudent, Renaud, primary, Moucadel, Virginie, primary, Nguyen, Chi-Hung, primary, Barette, Caroline, primary, Schmidt, Frédéric, primary, Florent, Jean-Claude, primary, Lafanechère, Laurence, primary, Sautel, Céline F, primary, Duchemin-Pelletier, Eve, primary, Spreux, Elodie, primary, Filhol, Odile, primary, Reiser, Jean-Baptiste, primary, and Cochet, Claude, primary

Published
2023
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22. Supplementary Figure 6 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Author

Prudent, Renaud, primary, Vassal-Stermann, Emilie, primary, Nguyen, Chi-Hung, primary, Pillet, Catherine, primary, Martinez, Anne, primary, Prunier, Chloé, primary, Barette, Caroline, primary, Soleilhac, Emmanuelle, primary, Filhol, Odile, primary, Beghin, Anne, primary, Valdameri, Glaucio, primary, Honoré, Stéphane, primary, Aci-Sèche, Samia, primary, Grierson, David, primary, Antonipillai, Juliana, primary, Li, Rong, primary, Di Pietro, Attilio, primary, Dumontet, Charles, primary, Braguer, Diane, primary, Florent, Jean-Claude, primary, Knapp, Stefan, primary, Bernard, Ora, primary, and Lafanechère, Laurence, primary

Published
2023
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23. Data from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Author

Prudent, Renaud, primary, Vassal-Stermann, Emilie, primary, Nguyen, Chi-Hung, primary, Pillet, Catherine, primary, Martinez, Anne, primary, Prunier, Chloé, primary, Barette, Caroline, primary, Soleilhac, Emmanuelle, primary, Filhol, Odile, primary, Beghin, Anne, primary, Valdameri, Glaucio, primary, Honoré, Stéphane, primary, Aci-Sèche, Samia, primary, Grierson, David, primary, Antonipillai, Juliana, primary, Li, Rong, primary, Di Pietro, Attilio, primary, Dumontet, Charles, primary, Braguer, Diane, primary, Florent, Jean-Claude, primary, Knapp, Stefan, primary, Bernard, Ora, primary, and Lafanechère, Laurence, primary

Published
2023
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24. Supplementary Figures 1-3 from Antitumor Activity of Pyridocarbazole and Benzopyridoindole Derivatives that Inhibit Protein Kinase CK2

Author

Prudent, Renaud, primary, Moucadel, Virginie, primary, Nguyen, Chi-Hung, primary, Barette, Caroline, primary, Schmidt, Frédéric, primary, Florent, Jean-Claude, primary, Lafanechère, Laurence, primary, Sautel, Céline F, primary, Duchemin-Pelletier, Eve, primary, Spreux, Elodie, primary, Filhol, Odile, primary, Reiser, Jean-Baptiste, primary, and Cochet, Claude, primary

Published
2023
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25. Supplementary Figure 3 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Author

Prudent, Renaud, primary, Vassal-Stermann, Emilie, primary, Nguyen, Chi-Hung, primary, Pillet, Catherine, primary, Martinez, Anne, primary, Prunier, Chloé, primary, Barette, Caroline, primary, Soleilhac, Emmanuelle, primary, Filhol, Odile, primary, Beghin, Anne, primary, Valdameri, Glaucio, primary, Honoré, Stéphane, primary, Aci-Sèche, Samia, primary, Grierson, David, primary, Antonipillai, Juliana, primary, Li, Rong, primary, Di Pietro, Attilio, primary, Dumontet, Charles, primary, Braguer, Diane, primary, Florent, Jean-Claude, primary, Knapp, Stefan, primary, Bernard, Ora, primary, and Lafanechère, Laurence, primary

Published
2023
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26. Supplementary Tables 1-3 from Antitumor Activity of Pyridocarbazole and Benzopyridoindole Derivatives that Inhibit Protein Kinase CK2

Author

Prudent, Renaud, primary, Moucadel, Virginie, primary, Nguyen, Chi-Hung, primary, Barette, Caroline, primary, Schmidt, Frédéric, primary, Florent, Jean-Claude, primary, Lafanechère, Laurence, primary, Sautel, Céline F, primary, Duchemin-Pelletier, Eve, primary, Spreux, Elodie, primary, Filhol, Odile, primary, Reiser, Jean-Baptiste, primary, and Cochet, Claude, primary

Published
2023
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27. Data from Antitumor Activity of Pyridocarbazole and Benzopyridoindole Derivatives that Inhibit Protein Kinase CK2

Author

Prudent, Renaud, primary, Moucadel, Virginie, primary, Nguyen, Chi-Hung, primary, Barette, Caroline, primary, Schmidt, Frédéric, primary, Florent, Jean-Claude, primary, Lafanechère, Laurence, primary, Sautel, Céline F, primary, Duchemin-Pelletier, Eve, primary, Spreux, Elodie, primary, Filhol, Odile, primary, Reiser, Jean-Baptiste, primary, and Cochet, Claude, primary

Published
2023
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28. Supplementary Figure 1 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Author

Prudent, Renaud, primary, Vassal-Stermann, Emilie, primary, Nguyen, Chi-Hung, primary, Pillet, Catherine, primary, Martinez, Anne, primary, Prunier, Chloé, primary, Barette, Caroline, primary, Soleilhac, Emmanuelle, primary, Filhol, Odile, primary, Beghin, Anne, primary, Valdameri, Glaucio, primary, Honoré, Stéphane, primary, Aci-Sèche, Samia, primary, Grierson, David, primary, Antonipillai, Juliana, primary, Li, Rong, primary, Di Pietro, Attilio, primary, Dumontet, Charles, primary, Braguer, Diane, primary, Florent, Jean-Claude, primary, Knapp, Stefan, primary, Bernard, Ora, primary, and Lafanechère, Laurence, primary

Published
2023
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29. Supplementary Figure 5 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Author

Prudent, Renaud, primary, Vassal-Stermann, Emilie, primary, Nguyen, Chi-Hung, primary, Pillet, Catherine, primary, Martinez, Anne, primary, Prunier, Chloé, primary, Barette, Caroline, primary, Soleilhac, Emmanuelle, primary, Filhol, Odile, primary, Beghin, Anne, primary, Valdameri, Glaucio, primary, Honoré, Stéphane, primary, Aci-Sèche, Samia, primary, Grierson, David, primary, Antonipillai, Juliana, primary, Li, Rong, primary, Di Pietro, Attilio, primary, Dumontet, Charles, primary, Braguer, Diane, primary, Florent, Jean-Claude, primary, Knapp, Stefan, primary, Bernard, Ora, primary, and Lafanechère, Laurence, primary

Published
2023
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30. Supplementary Video 1 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Author

Prudent, Renaud, primary, Vassal-Stermann, Emilie, primary, Nguyen, Chi-Hung, primary, Pillet, Catherine, primary, Martinez, Anne, primary, Prunier, Chloé, primary, Barette, Caroline, primary, Soleilhac, Emmanuelle, primary, Filhol, Odile, primary, Beghin, Anne, primary, Valdameri, Glaucio, primary, Honoré, Stéphane, primary, Aci-Sèche, Samia, primary, Grierson, David, primary, Antonipillai, Juliana, primary, Li, Rong, primary, Di Pietro, Attilio, primary, Dumontet, Charles, primary, Braguer, Diane, primary, Florent, Jean-Claude, primary, Knapp, Stefan, primary, Bernard, Ora, primary, and Lafanechère, Laurence, primary

Published
2023
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31. Supplementary Tables 1-9, Movie Legend, Methods from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Author

Prudent, Renaud, primary, Vassal-Stermann, Emilie, primary, Nguyen, Chi-Hung, primary, Pillet, Catherine, primary, Martinez, Anne, primary, Prunier, Chloé, primary, Barette, Caroline, primary, Soleilhac, Emmanuelle, primary, Filhol, Odile, primary, Beghin, Anne, primary, Valdameri, Glaucio, primary, Honoré, Stéphane, primary, Aci-Sèche, Samia, primary, Grierson, David, primary, Antonipillai, Juliana, primary, Li, Rong, primary, Di Pietro, Attilio, primary, Dumontet, Charles, primary, Braguer, Diane, primary, Florent, Jean-Claude, primary, Knapp, Stefan, primary, Bernard, Ora, primary, and Lafanechère, Laurence, primary

Published
2023
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32. Supplementary Figure 4 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Author

Prudent, Renaud, primary, Vassal-Stermann, Emilie, primary, Nguyen, Chi-Hung, primary, Pillet, Catherine, primary, Martinez, Anne, primary, Prunier, Chloé, primary, Barette, Caroline, primary, Soleilhac, Emmanuelle, primary, Filhol, Odile, primary, Beghin, Anne, primary, Valdameri, Glaucio, primary, Honoré, Stéphane, primary, Aci-Sèche, Samia, primary, Grierson, David, primary, Antonipillai, Juliana, primary, Li, Rong, primary, Di Pietro, Attilio, primary, Dumontet, Charles, primary, Braguer, Diane, primary, Florent, Jean-Claude, primary, Knapp, Stefan, primary, Bernard, Ora, primary, and Lafanechère, Laurence, primary

Published
2023
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33. Supplementary Figure 2 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Author

Prudent, Renaud, primary, Vassal-Stermann, Emilie, primary, Nguyen, Chi-Hung, primary, Pillet, Catherine, primary, Martinez, Anne, primary, Prunier, Chloé, primary, Barette, Caroline, primary, Soleilhac, Emmanuelle, primary, Filhol, Odile, primary, Beghin, Anne, primary, Valdameri, Glaucio, primary, Honoré, Stéphane, primary, Aci-Sèche, Samia, primary, Grierson, David, primary, Antonipillai, Juliana, primary, Li, Rong, primary, Di Pietro, Attilio, primary, Dumontet, Charles, primary, Braguer, Diane, primary, Florent, Jean-Claude, primary, Knapp, Stefan, primary, Bernard, Ora, primary, and Lafanechère, Laurence, primary

Published
2023
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35. CK2β-regulated signaling controls B cell differentiation and function

Author

Quotti Tubi, Laura, primary, Mandato, Elisa, additional, Canovas Nunes, Sara, additional, Arjomand, Arash, additional, Zaffino, Fortunato, additional, Manni, Sabrina, additional, Casellato, Alessandro, additional, Macaccaro, Paolo, additional, Vitulo, Nicola, additional, Zumerle, Sara, additional, Filhol, Odile, additional, Boldyreff, Brigitte, additional, Siebel, Christian W., additional, Viola, Antonella, additional, Valle, Giorgio, additional, Mainoldi, Federica, additional, Casola, Stefano, additional, Cancila, Valeria, additional, Gulino, Alessandro, additional, Tripodo, Claudio, additional, Pizzi, Marco, additional, Dei Tos, Angelo Paolo, additional, Trentin, Livio, additional, Semenzato, Gianpietro, additional, and Piazza, Francesco, additional

Published
2023
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38. AB668, a novel highly selective protein kinase CK2 inhibitor with a distinct anti-tumor mechanism as compared to CX-4945 and SGC-CK2-1

Author

Bancet, Alexandre, primary, Frem, Rita, additional, Jeanneret, Florian, additional, Mularoni, Angélique, additional, Bazelle, Pauline, additional, Roelants, Caroline, additional, Delcros, Jean-Guy, additional, Guichou, Jean-François, additional, Pillet, Catherine, additional, Coste, Isabelle, additional, Renno, Toufic, additional, Battail, Christophe, additional, Cochet, Claude, additional, Lomberget, Thierry, additional, Filhol, Odile, additional, and Krimm, Isabelle, additional

Published
2022
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48. Ex-Vivo Treatment of Tumor Tissue Slices as a Predictive Preclinical Method to Evaluate Targeted Therapies for Patients with Renal Carcinoma

Author

Roelants, Caroline, Pillet, Catherine, Franquet, Quentin, Sarrazin, Clément, Peilleron, Nicolas, Giacosa, Sofia, Guyon, Laurent, Fontanell, Amina, Fiard, Gaelle, Long, Jean-Alexandre, Descotes, Jean-Luc, Cochet, Claude, Filhol, Odile, Inovarion [Paris], Invasion mechanisms in angiogenesis and cancer (IMAC), Biologie du Cancer et de l'Infection (BCI ), Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Genetics and Chemogenomics (GenChem ), Laboratoire de Biologie à Grande Échelle (BGE - UMR S1038), Université Grenoble Alpes (UGA)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire [Grenoble] (CHU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), and Filhol, Odile

Subjects
immune infiltration, renal cancer, tumor slice culture, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, targeted therapy, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, lcsh:RC254-282, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Article, [SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], drug sensitivity
Abstract

International audience; Clear cell renal cell carcinoma (ccRCC) is the third type of urologic cancer. At time of diagnosis, 30% of cases are metastatic with no effect of chemotherapy or radiotherapy. Current targeted therapies lead to a high rate of relapse and resistance after a short-term response. Thus, a major hurdle in the development and use of new treatments for ccRCC is the lack of good pre-clinical models that can accurately predict the efficacy of new drugs and allow the stratification of patients into the correct treatment regime. Here, we describe different 3D cultures models of ccRCC, emphasizing the feasibility and the advantage of ex-vivo treatment of fresh, surgically resected human tumor slice cultures of ccRCC as a robust preclinical model for identifying patient response to specific therapeutics. Moreover, this model based on precision-cut tissue slices enables histopathology measurements as tumor architecture is retained, including the spatial relationship between the tumor and tumor-infiltrating lymphocytes and the stromal components. Our data suggest that acute treatment of tumor tissue slices could represent a benchmark of further exploration as a companion diagnostic tool in ccRCC treatment and a model to develop new therapeutic drugs.

Published
2020
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