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Objectives: The aim of this study is to assess the micro-tensile bond strength and the mode of failure of a bioactive hybrid self-adhesive composite (Surefil one) under various dentin conditions. Methods: Thirty-two extracted human molar teeth were used to test the micro-tensile bond strength of Surefil one under different dentine conditions (no treatment, 37% phosphoric acid etching, and universal adhesive) in comparison with a resin-modified glass ionomer (RIVA). All restorations were light cure-bonded onto flat dentine and then sectioned into beams. Then, fractured specimens were observed under a light microscope to evaluate the mode of failure. Results: The Surefil one no-treatment group (NTG) exhibited the highest micro-tensile bond strength. Furthermore, there was no statistically significant difference observed between the Surefil one adhesive group (EAG) and the Surefil one acid etch group (EG). However, compared to other groups, the resin-modified glass ionomer (RIVA) produced the lowest results, which are statistically significant. Conclusion: Surefil one offers superior bond strength values when compared to resin-modified glass ionomers. Furthermore, Surefil one requires no dentin condition and has more straightforward clinical steps. [ABSTRACT FROM AUTHOR]