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5. Scaffolds for Meniscus Regeneration

Author

Sessa, A., Perdisa, F., Kon, E., Marcacci, M., Filardo, G., Gobbi, Alberto, editor, Espregueira-Mendes, João, editor, Lane, John G., editor, and Karahan, Mustafa, editor

Published
2017
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13. Technique of chondrocytes implantation

Author

Zaffagnini, S., Kon, E., Filardo, G., Giordano, G., Delcogliano, M., Marcheggiani Muccioli, G. M., Marcacci, M., Bonnin, Michel, Amendola, Annunziato, Bellemans, Johan, MacDonald, Steven, and Ménétrey, Jacques

Published
2012
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28. Exercise training and atrial fibrillation: a systematic review and literature analysis

Author

Leggio, M, Fusco, Augusto, Coraci, Daniele, Villano, Antonio, Filardo, G, Mazza, A, Loreti, Claudia, Serafini, Elisabetta, Biscotti, L, Bernabei, Roberto, Padua, Luca, and Giovannini, Silvia

Subjects
Oxygen, Rehabilitation, Settore MED/09 - MEDICINA INTERNA, Atrial Fibrillation, Quality of Life, Humans, Patient Compliance, Walk Test, Exercise, Settore MED/34 - MEDICINA FISICA E RIABILITATIVA, Exercise Therapy
Abstract

There are concerns in maintaining adequate levels of physical activity in patients with atrial fibrillation (AF). This could be related to the type of exercise delivered, different among studies, as the words used to describe it as treatment. We have analysed the state-of-art of the role of the exercise in AF by a mathematical analysis. This analysis documented the connections between topics and updated the available evidence through a systematic review of the current literature.A literature search was conducted using specific terms for studies published between 2000 and 2019. For the descriptive analysis of the current literature, we used the LExical Network analysed by the Graph THeory (LENGTH) method, while to perform our review we followed the PRISMA statement. Downs and Black Quality Index was also used to assess the quality of studies. The LENGTH approach indicated nonspecific terms as "exercise", "physical" and "activity" as more representative than "rehabilitation" to describe the intervention.The systematic review identified nine studies on 882 patients of moderate (n=4) to good (n=5) quality. Training consisted of a combination of supervised ambulatory and home-based outpatient programs, focused on aerobic elements (endurance and resistance training, walking, treadmill and bicycle ergometer). Significant improvements in 6-minute walking test distance and peak oxygen uptake and in quality of life were obtained, with high adherence to training and no serious/significant adverse events. Only one trial was based on cardiac rehabilitation principles.Adequate exercise training can get a favourable cardiovascular outcome in patients with AF.

Published
2021

42. Corrigendum to “ACL reconstruction with lateral plasty reduces translational and rotatory laxity compared to anatomical single bundle and non-anatomical double bundle surgery: An in vivo kinematic evaluation with navigation system.” [Clin. Biomech. (Bristol, Avon) 2019 Oct; 69:1–8. doi:10.1016/j.clinbiomech.2019.06.012. Epub 2019 Jun 14]

Author

Grassi, A., primary, Signorelli, C., additional, Lucidi, G.A., additional, Raggi, F., additional, Macchiarola, L., additional, Roberti Di Sarsina, T., additional, Marcheggiani Muccioli, G.M., additional, Filardo, G., additional, and Zaffagnini, S., additional

Published
2020
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43. Maioregen

Author

Marcacci, M., Zaffagnini, S., Kon, E., Delcogliano, M., Di Martino, A., Filardo, G., Altadonna, G., and Balbonie, F.

Published
2009
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48. Cartilage mechanical tests: Evolution of current standards for cartilage repair and tissue engineering. A literature review

Author

Marchiori, G., Berni, M., Boi, M., Bianchi, M., and Filardo, G.

Subjects
Cartilage, Articular, Cartilage Tissue Engineering, Compression, Constitutive Modeling, Indentation, Standards, Animals, Humans, Models, Biological, Tissue Engineering, Computer science, Biophysics, Articular cartilage, Food and drug administration, 03 medical and health sciences, 0302 clinical medicine, Tissue engineering, Models, medicine, Orthopedics and Sports Medicine, Cartilage repair, Cartilage, Regeneration (biology), 030229 sport sciences, Standard methods, Biological, Clinical Practice, medicine.anatomical_structure, 030217 neurology & neurosurgery, Biomedical engineering, Articular
Abstract

Background Repair procedures and tissue engineering are solutions available in the clinical practice for the treatment of damaged articular cartilage. Regulatory bodies defined the requirements that any products, intended to regenerate cartilage, should have to be applied. In order to verify these requirements, the Food and Drug Administration (FDA, USA) and the International Standard Organization (ISO) indicated some Standard tests, which allow evaluating, in a reproducible way, the performances of scaffolds/treatments for cartilage tissue regeneration. Methods A review of the literature about cartilage mechanical characterization found 394 studies, from 1970 to date. They were classified by material (simulated/animal/human cartilage) and method (theoretical/applied; static/dynamic; standard/non-standard study), and analyzed by nation and year of publication. Findings While Standard methods for cartilage mechanical characterization still refer to studies developed in the eighties, expertise and interest on cartilage mechanics research are evolving continuously and internationally, with studies both in vitro – on human and animal tissues – and in silico, dealing with tissue function and modelling, using static and dynamic loading conditions. Interpretation there is a consensus on the importance of mechanical characterization that should be considered to evaluate cartilage treatments. Still, relative Standards need to be updated to describe advanced constructs and procedures for cartilage regeneration in a more exhaustive way. The use of the more complex, fibre-reinforced biphasic model, instead of the standard simple biphasic model, to describe cartilage response to loading, and the standardisation of dynamic tests can represent a first step in this direction.

Published
2019

49. Secretome and Extracellular Vesicles as New Biological Therapies for Knee Osteoarthritis: A Systematic Review

Author

D'Arrigo, D, Roffi, A, Cucchiarini, M, Moretti, M, Candrian, C, Filardo, G, D'Arrigo, Daniele, Roffi, Alice, Cucchiarini, Magali, Moretti, Matteo, Candrian, Christian, Filardo, Giuseppe, D'Arrigo, D, Roffi, A, Cucchiarini, M, Moretti, M, Candrian, C, Filardo, G, D'Arrigo, Daniele, Roffi, Alice, Cucchiarini, Magali, Moretti, Matteo, Candrian, Christian, and Filardo, Giuseppe

Abstract

Secretome and extracellular vesicles (EVs) are considered a promising option to exploit mesenchymal stem cells' (MSCs) properties to address knee osteoarthritis (OA). The aim of this systematic review was to analyze both the in vitro and in vivo literature, in order to understand the potential of secretome and EVs as a minimally invasive injective biological approach. A systematic review of the literature was performed on PubMed, Embase, and Web of Science databases up to 31 August 2019. Twenty studies were analyzed; nine in vitro, nine in vitro and in vivo, and two in vivo. The analysis showed an increasing interest in this emerging field, with overall positive findings. Promising in vitro results were documented in terms of enhanced cell proliferation, reduction of inflammation, and down-regulation of catabolic pathways while promoting anabolic processes. The positive in vitro findings were confirmed in vivo, with studies showing positive effects on cartilage, subchondral bone, and synovial tissues in both OA and osteochondral models. However, several aspects remain to be clarified, such as the different effects induced by EVs and secretome, which is the most suitable cell source and production protocol, and the identification of patients who may benefit more from this new biological approach for knee OA treatment

Published
2019

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