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3. Stochastic Equidistribution and Generalized Adelic Measures

Author

Doyle, John, Fili, Paul, and Tobin, Bella

Subjects
Mathematics - Number Theory, Mathematics - Dynamical Systems, 11G50, 37P30, 37P50, 37P05
Abstract

We study the dynamics of stochastic families of rational maps on the projective line. As such families can be infinite and may not typically be defined over a single number field, we introduce the concept of generalized adelic measures, generalizing previous notions introduced by Favre and Rivera-Letelier and Mavraki and Ye. Generalized adelic measures are defined over the measure space of places of an algebraic closure of the rationals, using a framework established by Allcock and Vaaler. This turns our heights from sums over places into integrals. We prove an equidistribution result for generalized adelic measures, and use this result to prove an equidistribution result for random backwards orbits in stochastic arithmetic dynamics., Comment: 54 pages

Published
2021

4. Wandering points for the Mahler measure

Author

Fili, Paul, Pottmeyer, Lukas, and Zhang, Mingming

Subjects
Mathematics - Number Theory, 11R06, 11R04, 11R20
Abstract

Mahler's measure defines a dynamical system on the algebraic numbers. In this paper, we study the problem of which number fields have points which wander under the iteration of Mahler's measure. We completely solve the problem for all abelian number fields, and more generally, for all extensions of the rationals of degree at most five.

Published
2021

5. Dynatomic polynomials, necklace operators, and universal relations for dynamical units

Author

Doyle, John R., Fili, Paul, and Hyde, Trevor

Subjects
Mathematics - Number Theory, Mathematics - Dynamical Systems, 37P05, 11R27, 37P35
Abstract

Given a generic polynomial $f(x)$, the generalized dynatomic polynomial $\Phi_{f,c,d}(x)$ vanishes at precisely those $\alpha$ such that $f^c(\alpha)$ has period exactly $d$ under iteration of $f(x)$. We show that the shifted dynatomic polynomials $\Phi_{f,c,d}(x) - 1$ often have generalized dynatomic factors, and that these factors are in correspondence with certain cyclotomic factors of necklace polynomials. These dynatomic factors of $\Phi_{f,c,d}(x) - 1$ have an interpretation in terms of new multiplicative relations between dynamical units which are uniform in the polynomial $f(x)$., Comment: 19 pages, comments welcome!

Published
2021

6. On the behavior of Mahler's measure under iteration

Author

Fili, Paul, Pottmeyer, Lukas, and Zhang, Mingming

Subjects
Mathematics - Number Theory, 11G50
Abstract

For an algebraic number $\alpha$ we denote by $M(\alpha)$ the Mahler measure of $\alpha$. As $M(\alpha)$ is again an algebraic number (indeed, an algebraic integer), $M(\cdot)$ is a self-map on $\overline{\mathbb{Q}}$, and therefore defines a dynamical system. The \emph{orbit size} of $\alpha$, denoted $\# \mathcal{O}_M(\alpha)$, is the cardinality of the forward orbit of $\alpha$ under $M$. We prove that for every degree at least 3 and every non-unit norm, there exist algebraic numbers of every orbit size. We then prove that for algebraic units of degree 4, the orbit size must be 1, 2, or infinity. We also show that there exist algebraic units of larger degree with arbitrarily large but finite orbit size., Comment: 19 pages

Published
2019
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8. A metric of mutual energy and unlikely intersections for dynamical systems

Author

Fili, Paul

Subjects
Mathematics - Number Theory, Mathematics - Dynamical Systems, 37P30, 31A15, 37P50, 11G50, 37P05
Abstract

We introduce a metric of mutual energy for adelic measures associated to the Arakelov-Zhang pairing. Using this metric and potential theoretic techniques involving discrete approximations to energy integrals, we prove an effective bound on a problem of Baker and DeMarco on unlikely intersections of dynamical systems, specifically, for the set of complex parameters $c$ for which $z=0$ and $1$ are both preperiodic under iteration of $f_c(z)=z^2 + c$., Comment: 17 pages

Published
2017

10. Effect of heparin treatment on pulmonary embolism and in-hospital death in unvaccinated COVID-19 patients without overt deep vein thrombosis

Author

Bais, Bruno, Sozio, Emanuela, De Silvestri, Daniele, Volpetti, Stefano, Zannier, Maria Elena, Filì, Carla, Bassi, Flavio, Alcaro, Lucia, Cotrufo, Marco, Pagotto, Alberto, Giacinta, Alessandro, Patruno, Vincenzo, Da Porto, Andrea, Sbrojavacca, Rodolfo, Curcio, Francesco, Tascini, Carlo, Sechi, Leonardo Alberto, and Colussi, GianLuca

Published
2022
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11. Quantitative height bounds under splitting conditions

Author

Fili, Paul and Pottmeyer, Lukas

Subjects
Mathematics - Number Theory, 11G50, 11R06, 37P30, 31A15
Abstract

In an earlier work, the first author and Petsche used potential theoretic techniques to establish a lower bound for the height of algebraic numbers that satisfy splitting conditions, such as being totally real or p-adic, improving on earlier work of Bombieri and Zannier in the totally p-adic case. These bounds applied as the degree of the algebraic number over the rationals tended towards infinity. In this paper, we use discrete energy approximation techniques on the Berkovich projective line to make the dependence on the degree in these bounds explicit, and we establish lower bounds for algebraic numbers which depend only on local properties of the numbers., Comment: This second version contains improvements of essentially all calculations, leading to better bounds in Theorems 1, 7, 10, 11 and 12. Some errors have been corrected. In particular, the statement from Proposition 14 was not correct in the first version. 22 pages

Published
2015
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12. Energy integrals and small points for the Arakelov height

Author

Fili, Paul, Petsche, Clayton, and Pritsker, Igor

Subjects
Mathematics - Number Theory, 11G50, 11R06, 37P30
Abstract

We study small points for the Arakelov height on the projective line. First, we identify the smallest positive value taken by the Arakelov height, and we characterize all cases of equality. Next we solve several archimedean energy minimization problems with respect to the chordal metric on the projective line, and as an application, we obtain lower bounds on the Arakelov height in fields of totally real and totally p-adic numbers., Comment: 12 pages

Published
2015

13. Height bounds for algebraic numbers satisfying splitting conditions

Author

Fili, Paul and Pritsker, Igor

Subjects
Mathematics - Number Theory, 11G50, 11R06, 37P30
Abstract

In an earlier work, the first author and Petsche solved an energy minimization problem for local fields and used the result to obtain lower bounds on the height of algebraic numbers all whose conjugates lie in various local fields, such as totally real and totally p-adic numbers. In this paper, we extend these techniques and solve the corresponding minimization programs for real intervals and p-adic discs, obtaining several new lower bounds for the height of algebraic numbers all of whose conjugates lie in such sets., Comment: 11 pages

Published
2015

14. On the non-Archimedean metric Mahler measure

Author

Fili, Paul and Samuels, Charles L.

Subjects
Mathematics - Number Theory, 11R04, 11R09 (Primary)
Abstract

Recently, Dubickas and Smyth constructed and examined the metric Mahler measure and the metric na\"ive height on the multiplicative group of algebraic numbers. We give a non-Archimedean version of the metric Mahler measure, denoted $M_\infty$, and prove that $M_\infty(\alpha) = 1$ if and only if $\alpha$ is a root of unity. We further show that $M_\infty$ defines a projective height on $\bar{\mathbb Q}^\times/ \bar{\mathbb Q}^\times_\mathrm{tors}$ as a vector space over $\mathbb Q$. Finally, we demonstrate how to compute $M_\infty(\alpha)$ when $\alpha$ is a surd.

Published
2014

15. Energy integrals over local fields and global height bounds

Author

Fili, Paul and Petsche, Clayton

Subjects
Mathematics - Number Theory, 11G50, 11R06, 37P30
Abstract

We solve an energy minimization problem for local fields. As an application of these results, we improve on lower bounds set by Bombieri and Zannier for the limit infimum of the Weil height in fields of totally p-adic numbers and generalizations thereof. In the case of fields with mixed archimedean and non-archimedean splitting conditions, we are able to combine our bounds with similar bounds at the archimedean places for totally real fields., Comment: 13 pages

Published
2013

16. On the heights of totally p-adic numbers

Author

Fili, Paul

Subjects
Mathematics - Number Theory, 11G50, 11R06, 37P30
Abstract

Bombieri and Zannier established lower and upper bounds for the limit infimum of the Weil height in fields of totally p-adic numbers and generalizations thereof. In this paper, we use potential theoretic techniques to generalize the upper bounds from their paper and, under the assumption of integrality, to improve slightly upon their bounds.

Published
2012

17. A generalization of Dirichlet's unit theorem

Author

Fili, Paul and Miner, Zachary

Subjects
Mathematics - Number Theory
Abstract

We generalize Dirichlet's $S$-unit theorem from the usual group of $S$-units of a number field $K$ to the infinite rank group of all algebraic numbers having nontrivial valuations only on places lying over $S$. Specifically, we demonstrate that the group of algebraic $S$-units modulo torsion is a $\bQ$-vector space which, when normed by the Weil height, spans a hyperplane determined by the product formula, and that the elements of this vector space which are linearly independent over $\mathbb{Q}$ retain their linear independence over $\mathbb{R}$.

Published
2012

18. Equidistribution and the heights of totally real and totally p-adic numbers

Author

Fili, Paul and Miner, Zachary

Subjects
Mathematics - Number Theory, Mathematics - Dynamical Systems, 11G50, 11R80, 37P30
Abstract

C.J. Smyth was among the first to study the spectrum of the Weil height in the field of all totally real numbers, establishing both lower and upper bounds for the limit infimum of the height of all totally real integers and determining isolated values of the height. Later, Bombieri and Zannier established similar results for totally p-adic numbers and, inspired by work of Ullmo and Zhang, termed this the Bogomolov property. In this paper, we use results on equidistribution of points of low height to generalize both Bogomolov-type results to a wide variety of heights arising in arithmetic dynamics.

Published
2012

19. On totally real numbers and equidistribution

Author

Fili, Paul and Miner, Zachary

Subjects
Mathematics - Number Theory, 11G50, 11R80, 37P30
Abstract

C.J. Smyth and later Flammang studied the spectrum of the Weil height in the field of all totally real numbers, establishing both lower and upper bounds for the limit infimum of the height of all totally real integers and determining isolated values of the height. We remove the hypothesis that we consider only integers and establish an lower bound on the limit infimum of the height for all totally real numbers. Our proof relies on a quantitative equidistribution theorem for numbers of small height.

Published
2012

20. Norms extremal with respect to the Mahler measure

Author

Fili, Paul and Miner, Zachary

Subjects
Mathematics - Number Theory
Abstract

In a previous paper, the authors introduced several vector space norms on the space of algebraic numbers modulo torsion which corresponded to the Mahler measure on a certain class of numbers and allowed the authors to formulate L^p Lehmer conjectures which were equivalent to their classical counterparts. In this paper, we introduce and study several analogous norms which are constructed in order to satisfy an extremal property with respect to the Mahler measure. These norms are a natural generalization of the metric Mahler measure introduced by Dubickas and Smyth. We evaluate these norms on certain classes of algebraic numbers and prove that the infimum in the construction is achieved in a certain finite dimensional space., Comment: 24 pages

Published
2010

21. Orthogonal decomposition of the space of algebraic numbers and Lehmer's problem

Author

Fili, Paul and Miner, Zachary

Subjects
Mathematics - Number Theory, 11R04, 11R06, 46E30
Abstract

We introduce vector space norms associated to the Mahler measure by using the L^p norm versions of the Weil height recently introduced by Allcock and Vaaler. In order to do this, we determine orthogonal decompositions of the space of algebraic numbers modulo torsion by Galois field and degree. We formulate L^p Lehmer conjectures involving lower bounds on these norms and prove that these new conjectures are equivalent to their classical counterparts, specifically, the classical Lehmer conjecture in the p = 1 case and the Schinzel-Zassenhaus conjecture in the p = infinity case., Comment: 29 pages

Published
2009

23. Risk-adapted MRD-directed therapy for young adults with acute myeloid leukemia: 6-year update of the GIMEMA AML1310 trial

Author

Venditti, Adriano, Piciocchi, Alfonso, Candoni, Anna, Arena, Valentina, Palmieri, Raffaele, Filì, Carla, Carella, Angelo Michele, Calafiore, Valeria, Cairoli, Roberto, de Fabritiis, Paolo, Storti, Gabriella, Salutari, Prassede, Lanza, Francesco, Martinelli, Giovanni, Curti, Antonio, Luppi, Mario, Ingrosso, Claudia, Martelli, Maria Paola, Cuneo, Antonio, Albano, Francesco, Mulè, Antonino, Tafuri, Agostino, Cudillo, Laura, Tieghi, Alessia, Fracchiolla, Nicola Stefano, Capelli, Debora, Trisolini, Silvia Maria, Alati, Caterina, La Sala, Edoardo, Maurillo, Luca, Del Principe, Maria Ilaria, Irno Consalvo, Maria Antonietta, Divona, Maria Domenica, Ottone, Tiziana, Cerretti, Raffaella, Sconocchia, Giuseppe, Voso, Maria Teresa, Fazi, Paola, Vignetti, Marco, and Buccisano, Francesco

Published
2024
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24. Role of bone marrow biopsy in staging of patients with classical Hodgkin’s lymphoma undergoing positron emission tomography/computed tomography

Author

Puccini, B ., Nassi, L., Minoia, C., Volpetti, S., Ciancia, R., Riccomagno, P. C., Di Rocco, A., Mulè, A., Toldo, C., Sassone, M. C., Guariglia, R., Filì, C., Finolezzi, E., Falorio, S., Zanon, S., Furlan, A., Doa, G., Zaja, F., and on behalf of the Fondazione Italiana Linfomi Postgraduate Master course

Published
2017
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30. Patients presenting with metastases: stage IV uveal melanoma, an international study

Author

Garg, Gaurav, Finger, Paul T, Kivela¨, Tero T, Simpson, E Rand, Gallie, Brenda L, Saakyan, Svetlana, Amiryan, Anush G, Valskiy, Vladimir, Chin, Kimberly J, Semenova, Ekaterina, Seregard, Stefan, Filì, Maria, Wilson, Matthew, Haik, Barrett, Caminal, Josep Maria, Catala-Mora, Jaume, Gutiérrez, Cristina, Pelayes, David E, Folgar, Anibal Martin, Jager, Martine Johanna, Doğruso¨z, Mehmet, Luyten, Gregorius P M, Singh, Arun D, and Suzuki, Shigenobu

Abstract

ObjectiveTo analyse ocular and systemic findings of patients presenting with systemic metastasis.Methods and analysisIt is an international, multicentre, internet-enabled, registry-based retrospective data analysis. Patients were diagnosed between 2001 and 2011. Data included: primary tumour dimensions, extrascleral extension, ciliary body involvement, American Joint Committee on Cancer (AJCC)-tumour, node, metastasis staging, characteristics of metastases.ResultsOf 3610 patients with uveal melanoma, 69 (1.9%; 95% CI 1.5 to 2.4) presented with clinical metastasis (stage IV). These melanomas originated in the iris, ciliary body and choroid in 4%, 16% and 80% of eyes, respectively. Using eighth edition AJCC, 8 (11%), 20 (29%), 24 (35%), and 17 (25%) belonged to AJCC T-categories T1–T4. Risk of synchronous metastases increased from 0.7% (T1) to 1.5% (T2), 2.6% (T3) and 7.9% (T4). Regional lymph node metastases (N1a) were detected in 9 (13%) patients of whom 6 (67%) had extrascleral extension. Stage of systemic metastases (known for 40 (59%) stage IV patients) revealed 14 (35%), 25 (63%) and 1 (2%) had small (M1a), medium-sized (M1b) and large-sized (M1c) metastases, respectively. Location of metastases in stage IV patients were liver (91%), lung (16%), bone (9%), brain (6%), subcutaneous tissue (4%) and others (5%). Multiple sites of metastases were noted in 24%. Compared with the 98.1% of patients who did not present with metastases, those with synchronous metastases had larger intraocular tumours, more frequent extrascleral extension, ciliary body involvement and thus a higher AJCC T-category.ConclusionsThough higher AJCC T-stage was associated with risk for metastases at diagnosis, even small T1 tumours were stage IV at initial presentation. The liver was the most common site of metastases; however, frequent multiorgan involvement supports initial whole-body staging.

Published
2022
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31. Effect of plaque brachytherapy dose and dose rate on risk for disease-related mortality in 1238 patients with choroidal melanoma

Author

Filì, Maria, Trocme, Eric, Herrspiegel, Christina, Seregard, Stefan, and Stålhammar, Gustav

Abstract

BackgroundEpiscleral brachytherapy is the most common treatment for medium-sized choroidal melanomas. Although controversial, inadequate brachytherapy dose and dose rates have at least a hypothetical implication on patient survival.MethodsAll patients who received ruthenium-106 or iodine-125 brachytherapy for choroidal melanoma at St. Erik Eye Hospital 1996 to 2016 were included (n=1238). Cox regression hazard ratios for melanoma-related mortality across deciles, quartiles and individual integers of apex radiation doses (Gy) and dose rates (Gy/hour) were calculated, adjusted for tumour size and location.ResultsThe average radiation dose at the tumour apex ranged from 73.0 Gy in the first decile to 108.6 Gy in the tenth. Decreasing apex dose by 1 Gy increments or by decile or quartile group was not associated with melanoma-related mortality (p>0.2) The average radiation dose rate at the tumour apex ranged from 0.5 Gy/hour in the first decile to 2.8 Gy/hour in the tenth. Similarly, decreasing apex dose rate by 1 Gy/hour increments or by decile or quartile groups was not associated with melanoma-related mortality (p>0.5).ConclusionThere are no increased hazards for choroidal melanoma-related mortality after brachytherapy with decreasing doses between 108.6 and 73.0 Gy, or with decreasing dose rates between 2.8 and 0.5 Gy/hour.

Published
2021
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32. geni psicosi e cannabis: caratteristiche di un campione siciliano rappresentativo di pazienti al primo episodio psicotico

Author

Mulè, A, Bellavia, C, BRUNO, Alessandro, D’Alessandro, A, Di Caro, A, DI GIORGIO, Vassilij, Farinella, C, FERRARO, Laura, Filì, P, GRASSIA, Roberta, GRILLO, Graziella, LA CASCIA, Caterina, LA PLACA, Maddalena, Marchese, F, MARRAZZO, Giovanna, MISTRETTA, Claudia, RUMEO, Maria Valentina, SARTORIO, Crocettarachele, SIDELI, Lucia, Uccello, O, LA BARBERA, Daniele, D, Mulè, A, Bellavia, C, Bruno, A, D’Alessandro, A, Di Caro, A, Di Giorgio, V, Farinella, C, Ferraro, L, Filì, P, Grassia, R, Grillo, G, La Cascia, C, La Placa, M, Marchese, F, Marrazzo, G, Mistretta, C, Rumeo, MV, Sartorio, C, Sideli, L, Uccello, O, and La Barbera, D

Subjects
Settore MED/25 - Psichiatria, firt episode, cannibis, epidemiologia
Published
2010

33. QUALITà DELLA VITA IN GRAVIDANZA E VARIABILI PSICOLOGICHE: UN CONTRIBUTO DI RICERCA

Author

LA BARBERA, Daniele, BARRALE, L, CATANIA, R, FILì, P, GUARNERI, G, RUBINO, MA, RUGGIRELLO, I, RUMEO, V, RUSSO, E, SCHIMMENIT, A, VELA, A., LA BARBERA, D, BARRALE, L, CATANIA, R, FILì, P, GUARNERI, G, RUBINO, MA, RUGGIRELLO, I, RUMEO, V, RUSSO, E, SCHIMMENIT, A, and VELA, A

Subjects
gravidanza, alessitimia, qualità di vita, Settore MED/25 - Psichiatria
Abstract

La ricerca si propone di valutare l'andamento della qualità della vita e l'evoluzione dei sintomi depressivi durante la gravidanza, utilizzando appositi strumenti psicometrici somministrati a un campione di 90 donne, durante i tre trimestri di gravidanza. Particolarmente interessante si è rivelata l'analisi longitudinale della tonalità depressiva: il trend sembra decrescere nell'ultimo trimestre, parallelamente all'aumento dello stato di salute mentale. Nel post-partum si evidenzierebbe un incremento della tonalità depressiva e un miglioramento della componenete fisica della slaute, a sfavore della componente mentale. Nel complesso i datiemersi dall'evoluzione dei sintomi depressivi sono in sintonia con quelli presentati in letteratura, sembrerebbero confermare la nostra ipotesi riguardo la necessità di attuare modelli di prevenzione che mirino a tutelare la salute fisica della donna in gravidanza e a garantirle una buona assistenza psicologica.

Published
2010

35. Ruthenium-106 versus iodine-125 plaque brachytherapy of 571 choroidal melanomas with a thickness of ≥5.5 mm

Author

Filì, Maria, Trocme, Eric, Bergman, Louise, See, Thonnie Rose Ong, André, Helder, Bartuma, Katarina, Girnita, Leonard, All-Eriksson, Charlotta, Seregard, Stefan, and Stålhammar, Gustav

Abstract

BackgroundEpiscleral brachytherapy is the most common eye-preserving treatment for medium-sized choroidal melanomas. γ-emitting iodine-125 (125I) and β-emitting ruthenium-106 (106Ru) are widely used. The latter is however generally reserved for thinner tumours (<6 mm). In this study, we compare ocular and patient survival in thicker tumours treated with the respective radioisotope.MethodsAll patients with ≥5.5 mm thick choroidal melanomas who were treated with plaque brachytherapy at a single institution between 1 November 1979 and 31 December 2015 were included (n=571). Size-controlled Cox regression HRs for postbrachytherapy enucleation, repeated brachytherapy and melanoma-related mortality were calculated, as well as Kaplan-Meier disease-specific survival and relative 10-year survival in matched subgroups.Results317 patients were treated with 106Ru and 254 with 125I. The rate of repeated brachytherapy was significantly higher among patients treated with 106Ru (8%) than with 125I (1%, p<0.001). Size-controlled Cox regression HRs for postbrachytherapy enucleation (125I vs 106Ru 0.7, p=0.083) and melanoma-related mortality were not significant (125I vs 106Ru 1.1, p=0.63). Similarly, Kaplan-Meier disease-specific and relative 10-year survival was comparable in matched groups of 5.5–7.4 mm (relative survival 106Ru 59%, 125I 56%) and ≥7.5 mm thick tumours (relative survival 106Ru 46%, 125I 44%).ConclusionsRates of repeated brachytherapy were significantly higher among patients treated with 106Ru versus 125I for thick choroidal melanomas. There were, however, no significant differences in rates of enucleation or patient survival.

Published
2020
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36. No Gender Differences in Long-Term Survival after Brachytherapy of 1,541 Patients with Uveal Melanoma

Author

Stålhammar, Gustav, See, Thonnie Rose, Filì, Maria, and Seregard, Stefan

Abstract

Background:In several malignancies, gender-based survival differences after specific therapeutic interventions have been demonstrated. It is not known whether such differences exist after plaque brachytherapy of uveal melanoma. Methods:All patients who received brachytherapy for uveal melanoma at St. Erik Eye Hospital from November 1, 1979 through November 20, 2017 were included (n= 1,541). Retrospective data were retrieved including baseline patient and tumor characteristics, brachytherapy nuclide (ruthenium-106 or iodine-125), radiation dose, treatment duration, tumor relapses, date of metastasis, and cause of death. Results:A total of 775 men and 766 women were treated with plaque brachytherapy. There were no significant differences between the genders in baseline characteristics, treatment, or follow-up. Men and women had similar rates of tumor relapses, hazard for repeated brachytherapy (men vs. women 0.8, p= 0.47), enucleation-free survival, and survival after detection of metastasis. Five-, 10-, and 15-year melanoma-related mortality was 14, 24, and 27% for men and 15, 26, and 32% for women, respectively. There were no significant differences in hazard for melanoma-related mortality (men vs. women 0.9, p= 0.32), median Kaplan-Meier disease-specific survival (men 18.2 years, women 15.5 years, p= 0.22), or median overall survival (men 13.5 years, women 12.6 years, p= 0.60). Conclusion:There are no relevant differences between men and women in ocular or patient survival after brachytherapy for uveal melanoma.

Published
2019
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37. Circulatory response to volume expansion and transjugular intrahepatic portosystemic shunt in refractory ascites: Relationship with diastolic dysfunction.

Author

Filì, Daniela, Falletta, Calogero, Luca, Angelo, Hernandez Baravoglia, Cesar, Clemenza, Francesco, Miraglia, Roberto, Scardulla, Cesare, Tuzzolino, Fabio, Vizzini, Giovanni, Gridelli, Bruno, and Bosch, Jaime

Abstract

Background Cirrhotic cardiomyopathy may lead to heart failure in stressful circumstances, such as after transjugular intrahepatic portosystemic shunt (TIPS) placement. Aim To examine whether acute volume expansion predicts haemodynamic changes after TIPS and elicits signs of impending heart failure. Methods We prospectively evaluated refractory ascites patients (group A) and compensated cirrhotics (group B), who underwent echocardiography, NT-proBNP measurement, and heart catheterization before and after volume load; group A repeated measurements after TIPS. Results 15 patients in group A (80% male; 54 ± 12.4 years) and 8 in group B (100% male; 56 ± 6.2 years) were enrolled. Echocardiography disclosed diastolic dysfunction in 30% and 12.5%, respectively. In group A, volume load and TIPS induced a significant increase in right atrial, mean pulmonary, capillary wedge pressure and cardiac index, and a decrease in systemic vascular resistance (respectively, 4.7 ± 2.8 vs. 9.9 ± 3.6 mmHg; 13.3 ± 3.5 vs. 21.9 ± 5.9 mmHg; 8.3 ± 3.4 vs. 15.4 ± 4.7 mmHg; 3.7 ± 0.7 vs. 4.6 ± 1 lt/min/m 2 ; 961 ± 278 vs. 767 ± 285 dyn s cm −5 ; and 10.1 ± 3.3 vs. 14.2 ± 3.4 mmHg; 17.5 ± 4 vs. 25.2 ± 4.2 mmHg; 12.3 ± 4 vs. 19.3 ± 3.4 mmHg; 3.4 ± 0.8 vs. 4.5 ± 0.91 lt/min/m 2 ; 779 ± 62 vs. 596 ± 199 dyn s cm −5 , p < 0.001 for all pairs). At 24 h, cardiopulmonary pressures returned towards baseline. Conclusions Acute volume expansion predicted haemodynamic changes immediately after TIPS. All patients had adequate haemodynamic adaptation to TIPS; none developed signs of heart failure. [ABSTRACT FROM AUTHOR]

Published
2015
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38. Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction.

Author

Liotta, Francesco, Frosali, Francesca, Querci, Valentina, Mantei, Andrej, Filì, Lucia, Maggi, Laura, Mazzinghi, Benedetta, Angeli, Roberta, Ronconi, Elisa, Santarlasci, Veronica, Biagioli, Tiziana, Lasagni, Laura, Ballerini, Clara, Parronchi, Paola, Scheffold, Alexander, Cosmi, Lorenzo, Maggi, Enrico, Romagnani, Sergio, and Annunziato, Francesco

Subjects
GENETICS, DENDRITIC cells, PHENOTYPES, MYELOID leukemia
Abstract

Background: The mechanisms by which human dendritic cells (DCs) activate a TH1-polarizing or TH2-polarizing program are still partially unclear. Objective: Study of the mechanisms responsible for the TH1/TH2-polarizing activity of human circulating myeloid DCs before and after ligation of their Toll-like receptors (TLRs). Methods: IL-4 and IFN-γ production by CD4+ T cells was assessed in cocultures with myeloid DCs before or after TLR triggering. Expression of Jagged-1 and Delta-4 Notch ligands and of GATA-3 and T-box expressed in T cells transcription factors was evaluated by real-time quantitative PCR. Signal transducer and activator of transcription 4 and 6 phosphorylation was assessed by flow cytometry. Knockdown of Jagged-1 or Delta-4 was performed by transfection of DCs with appropriate silencing mRNAs. Results: Myeloid immature DCs constitutively expressed Jagged-1, which induces in CD4+ T cells a TH2 polarization, as shown by Jagged-1 gene silencing. The TH2 polarization associated with high GATA-3/T-box expressed in T cells ratio and was at least partially dependent on the early induction of IL-4. Maturation of DCs by TLR ligation resulted in the reduction of Jagged-1 and upregulation of Delta-4, which was at least in part responsible for the polarization of CD4+ T cells to the TH1 phenotype. Conclusion: CD4+ T-cell responses are usually characterized by a prevalent TH2 phenotype unless TLRs are triggered on DCs by microbial components. [Copyright &y& Elsevier]

Published
2008
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39. Redirection of allergen-specific TH2 responses by a modified adenine through Toll-like receptor 7 interaction and IL-12/IFN release.

Author

Filì, Lucia, Ferri, Simona, Guarna, Francesco, Sampognaro, Salvatore, Manuelli, Cinzia, Liotta, Francesco, Cosmi, Lorenzo, Matucci, Andrea, Vultaggio, Alessandra, Annunziato, Francesco, Maggi, Enrico, Guarna, Antonio, Romagnani, Sergio, and Parronchi, Paola

Subjects
ALLERGENS, CELL receptors, LYMPHOCYTES, CYTOKINES
Abstract

Background: Natural or synthetic ligands of Toll-like receptors (TLRs), such as CpG-containing oligodeoxynucleotides and imidazoquinolines, affect the functional phenotype of antigen-specific human T lymphocytes by inducing cytokine release by cells of the innate immunity. Objective: In vitro investigation of the ability of substitute adenines (SAs) to affect antigen-presenting cells and shift the functional phenotype of specific human TH2 cells was performed. Methods: The functional profile of hapten- and allergen-specific T-cell lines obtained in the absence or presence of modified adenines was assessed by means of quantitative real-time PCR, flow cytometry, and ELISAs. Activation of TLRs was evaluated by means of nucleofection of HEK293 cells. Results: The synthetic heterocycle, chemically related to adenine with substitution in positions 2-, 8-, and 9- (SA-2), but not its related derivative lacking 2- and 8- substitutions, stimulated the production of high amounts of IL-12, IL-10, TNF-α, and IL-6 by CD14+ cells and IFN-α and CXCL10 by blood dendritic cell antigen (BDCA)-4+ plasmacytoid dendritic cells. A nuclear factor κB–dependent signaling pathway mediated by SA-2 ligation of TLR7 was responsible for these effects. SA-2 also redirected the in vitro differentiation of either Dermatophagoides pteronyssinus group 1 or amoxicillin-specific TH2 cells toward the TH1/TH0 phenotype, with parallel downregulation of GATA-3 and upregulation of T-box expressed in T cells transcription factors. Conclusion: Critical substitutions of the adenine backbone confer the ability to activate TLR7, inducing the production of modulatory cytokines able to shift human allergen-specific TH2 cells to a TH1/TH0 phenotype. Clinical implications: Appropriately modified adenines might be used as effective adjuvants for the development of novel immunotherapeutic strategies of allergic disorders. [Copyright &y& Elsevier]

Published
2006
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40. CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine production.

Author

Romagnani, Paola, Maggi, Laura, Mazzinghi, Benedetta, Cosmi, Lorenzo, Lasagni, Laura, Liotta, Francesco, Lazzeri, Elena, Angeli, Roberta, Rotondi, Mario, Filì, Lucia, Parronchi, Paola, Serio, Mario, Maggi, Enrico, Romagnani, Sergio, and Annunziato, Francesco

Subjects
CYTOKINES, T cells, IMMUNOREGULATION, ENZYME-linked immunosorbent assay
Abstract

Background: Two variants of the CXCR3 receptor exist, one (CXCR3-A) reactive with CXCL9, CXCL10, and CXCL11 and the other (CXCR3-B) also reactive with CXCL4. Both variants are contemporarily expressed by human T cells. Objective: We sought to investigate the in vitro effects of CXCL10 and CXCL4 on the production of TH1 or TH2 cytokines. Methods: The cytokine profile of antigen-specific human CD4+ T-cell lines obtained in the absence or presence of CXCL10 or CXCL4 was evaluated by means of quantitative RT-PCR, flow cytometry, and ELISA. Results: CXCL10 upregulated IFN-γ and downregulated IL-4, IL-5, and IL-13 production, whereas CXCL4 downregulated IFN-γ and upregulated TH2 cytokines. Similar effects were also observed on polyclonally activated pure naive CD4+ T cells. The opposite effects of CXCL10 and CXCL4 on TH1 and TH2 cytokine production were inhibited by an anti-CXCR3 antibody able to neutralize both CXCR3-A and CXCR3-B and were apparently related to the activation of distinct signal transduction pathways. Moreover, CXCL10 upregulated mRNA levels of T-box expressed in T cells and downregulated GATA-3 expression, whereas CXCL4 downregulated T-box expressed in T cells and upregulated GATA-3. Finally, CXCL4, but not CXCL10, induced direct activation of IL-5 and IL-13 promoters. Conclusion: CXCL10 and CXCL4 exert opposite effects on the production of human TH1 and TH2 cytokines, likely through their respective interaction with CXCR3-A or CXCR3-B and the consequent activation of different signal transduction pathways. This might represent an internal regulatory pathway of TH cell responses and might contribute to the modulation of chronic inflammatory reactions, including allergy. [Copyright &y& Elsevier]

Published
2005
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41. 7th Drug hypersensitivity meeting: part two

Author

Elera, Javier Dionicio, Boteanu, Cosmin, Blanco, Maria Aranzazu Jimenez, Gonzalez-Mendiola, Rosario, García, Irene Carrasco, Alvarez, Antonio, Martinez, Jose Julio Laguna, Garrido, Jaume Martí, Barona, Carla Torán, Chorda, Carolina Perales, Salgueiro, Ramón López, Palacios, Miguel Díaz, De Rojas, Dolores Hernández Fernández, Acar, Emre Ali, Aktas, Ayse, Ermertcan, Aylin Türel, Temiz, Peyker, Lin, Chien-Yio, Hui, Chung-Yee Rosaline, Chang, Ya-Ching, Yang, Chih-Hsun, Chung, Wen-Hung, Carolino, Fabrícia, Silva, Diana, De Castro, Eunice Dias, Cernadas, Josefina R., Ensina, Luis Felipe, Aranda, Carolina, Nunes, Ines Camelo, Lacerda, Alex, Martins, Ana Maria, Goudouris, Ekaterini, Ribeiro, Marcia, Da Silva Franco, José Francisco, Queiroz, Leandra, Solé, Dirceu, Dalgiç, Ceyda Tunakan, Sin, Aytül Zerrin, Günsen, Fatma Düsünür, Bulut, Gökten, Ardeniz, Fatma Ömür, Gülbahar, Okan, Gökmen, Emine Nihal Mete, Kokuludag, Ali, De Francisco, Ana M. Montoro, De Vicente Jiménez, Talía Mª, Mendoza Parra, Adriana M., Burgos Pimentel, Angella M., Luque, Amelia García, Amaral, Luis, Leão, Leonor Carneiro, Pinto, Nicole, Belo, Joana, Marques, João, Carreiro-Martins, Pedro, Leiria-Pinto, Paula, Chaabane, Amel, Romdhane, Haifa Ben, Fredj, Nadia Ben, Chadly, Zohra, Boughattas, Naceur A., Aouam, Karim, Uyttebroek, Astrid P., Bridts, Chris H., Romano, Antonino, Ebo, Didier G., Sabato, Vito, Lopes, Anabela, Cosme, Joana, Aguiar, Rita, Lourenço, Tatiana, Paes, Maria-João, Spínola-Santos, Amélia, Pereira-Barbosa, Manuel, Cruz, Cíntia Rito, Dos Reis, Rute Pereira, Tomaz, Elza, Pires, Ana Paula, Inácio, Filipe, Benito-Garcia, Filipe, Mota, Inês, Correia, Magna, Gaspar, Ângela, Chambel, Marta, Piedade, Susana, Morais-Almeida, Mário, Nakonechna, Alla, Antipkin, Yurij, Umanets, Tetiana, Pineda, Fernando, Arribas, Francisca, Lapshyn, Volodymyr, Miranda, Pablo Andrés, De La Cruz Hoyos, Bautista, Blanco, Aranzazu Jimenez, Del Pozo, Marta, Vultaggio, Alessandra, Nencini, Francesca, Pratesi, Sara, Matucci, Andrea, Maggi, Enrico, Cegec, Ivana, Nahal, Danica Juricic, Turk, Viktorija Erdeljic, Aumiler, Matea Radacic, Ausperger, Ksenija Makar, Kraljickovic, Iva, Simic, Iveta, Yamaguchi, Yukie, Watanabe, Tomoya, Satoh, Megumi, Tanegashima, Tomohiko, Oda, Kayoko, Wada, Hidefumi, Aihara, Michiko, Lee, Jaechun Jason, Choi, Jay Chol, Lee, Hwa Young, Fernandes, Rosa-Anita Rodrigues, Faria, Emília, Pita, Joana, Sousa, Nuno, Ribeiro, Carmelita, Carrapatoso, Isabel, Bom, Ana Todo, Rodolfo, Ana, Dias-Castro, Eunice, Voronova, Marina, Valle, Diana Kury, Coronel, Verónica Pacheco, Chordá, Carolina Perales, Madamba, Roselle Catherine Yu, Ferrer, Marta, Goikoetxea, Maria Jose, D’Amelio, Carmen, Bernad, Amalia, Vega, Olga, Gastaminza, Gabriel, Bibián, Beatriz Pola, Salazar, Marina Lluncor, Vilà-Nadal, Gemma, Roman, Ana María Fiandor, Ortega, Javier Dominguez, Muñoz, Miguel Gonzalez, Gancedo, Santiago Quirce, Moreno, Maria Rosario Cabañas, Hofmeier, Kathrin Scherer, Barzylovych, Vladyslava, Pola, Beatriz, Lluncor, Marina, Fiandor, Ana, Bellón, Teresa, Domínguez, Javier, Quirce, Santiago, Yang, Min-Suk, Kim, Sun-Sin, Kim, Sae-Hoon, Kang, Hye-Ryun, Park, Heung-Woo, Cho, Sang-Heon, Min, Kyung-Up, Chang, Yoon-Seok, Delahaye, Clémence, Flabbee, Jenny, Waton, Julie, Bauvin, Olivia, Barbaud, Annick, Fadhel, Najah Ben, Gulin, Sandra Jerkovic, Chiriac, Anca, Cardoso, Bárbara Kong, Viseu, Regina, Moreira, Ana, Cadinha, Susana, Neves, Ana Castro, Barreira, Patrícia, Malheiro, Daniela, Da Silva, J. P. Moreira, Jurakic-Toncic, Ružica, Ljubojevic, Suzana, Turcic, Petra, Gilissen, Liesbeth, Huygens, Sara, Goossens, An, Andreu, Inmaculada, Romero, Alicia Martinez, Cabezas, Pau Gomez, Parejo, Pedro Ayuso, Del Carmen Plaza-Serón, Maria, Doña, Inmaculada, Blanca-López, Natalia, Flores, Carlos, Galindo, María Luisa, Molina, Ana, Perkins, James Richard, Cornejo-García, José Antonio, García-Agúndez, José Augusto, García-Martín, Elena, Campo, Paloma, Canto, María Gabriela, Blanca, Miguel, Guéant-Rodríguez, Rosa María, Jurado-Escobar, Raquel, Barrionuevo, Esther, Salas, María, Canto, Gabriela, Guéant, Jean-Louis, Usui, Toru, Tailor, Arun, Faulkner, Lee, Farrell, John, Alfirevic, Ana, Kevin Park, B., Naisbitt, Dean J., Trelles, Oswaldo, Guerrero, María Auxiliadora, Upton, Alex, Ueta, Mayumi, Sawai, Hiromi, Sotozono, Chie, Tokunaga, Katushi, Kinoshita, Shigeru, Sukasem, Chonlaphat, Satapornpong, Patompong, Tempark, Therdpong, Rerknimitr, Pawinee, Pairayayutakul, Kulprapat, Klaewsongkram, Jettanong, Koomdee, N., Jantararoungtong, T., Santon, S., Puangpetch, A., Intusoma, U., Tassaneeyakul, W., Theeramoke, V., Ramirez, Elena, Borobia, Alberto Manuel, Tong, Hoi, Castañer, Jose Luis, De Abajo, Francisco José, Galvao, Violeta Régnier, Pavlos, Rebecca, Mckinnon, Elizabeth, Williams, Kristina, Beeghly-Fadiel, Alicia, Redwood, Alec, Phillips, Elizabeth, Castells, Mariana, Boni, Elisa, Russello, Marina, Mauro, Marina, Ue, Kok Loong, Rutkowski, Krzysztof, Gomis, Victor Soriano, Ferre, Jorge Frances, Rodriguez, Angel Esteban, Reig, Vicente Cantó, Sanchez, Javier Fernandez, Breynaert, Christine, Van Hoeyveld, Erna, Schrijvers, Rik, Irigoyen, Raquel Fuentes, Collado, Daniel, Vida, Yolanda, Najera, Francisco, Perez-Inestrosa, Ezequiel, Mesa-Antunez, Pablo, Mayorga, Cristobalina, Torres, María José, Tannert, Line K., Mortz, Charlotte G., Skov, Per Stahl, Bindslev-Jensen, Carsten, Pfützner, Wolfgang, Dörnbach, Hannah, Visse, Johanna, Rauber, Michele, Möbs, Christian, Elzagallaai, Abdelbaset A., Chow, Lindsey, Abuzgaia, Awatif M., Rieder, Michael J., Trubiano, Jason, Woolnough, Emily, Stautins, Kaija, Cheng, Christina, Kato, Kenichi, Azukizawa, Hiroaki, Hanafusa, Takaaki, Katayama, Ichiro, Fujiyama, Toshiharu, Hashizume, Hideo, Umayahara, Takatsune, Ito, Taisuke, Tokura, Yoshiki, Silar, Mira, Zidarn, Mihaela, Rupnik, Helena, Korosec, Peter, Redwood, Alec James, Strautins, Kaija, White, Katie, Chopra, Abha, Konvinse, Katherine, Leary, Shay, Mallal, Simon, Cabañas, Rosario, Fiandor, Ana María, Sullivan, Andrew, Whitaker, Paul, Peckham, Daniel, Haw, Wei Yann, Polak, Marta E., Mcguire, Carolann, Ardern-Jones, Michael R., Aoyama, Yumi, Shiohara, Tetsuo, Correia, Sara, Gelincik, Asli, Demir, Semra, Sen, Fatma, Bozbey, Hamza Ugur, Olgac, Muge, Unal, Derya, Coskun, Raif, Colakoglu, Bahauddin, Buyuozturk, Suna, Çatin-Aktas, Esin, Deniz, Gunnur, Laguna, Jose Julio, Dionicio, J., Fernandez, Tahia, Olazabal, I., Ruiz, Maria Dolores, Torres, Maria José, Lafuente, Alberto, Núñez, Jorge, Fernández, Tahia Diana, Palomares, Francisca, Fernández, Rubén, Sanchez, Maria Isabel, Fernandez, Tahía, Ruiz, Arturo, Ariza, Adriana, Alonso, Amalia Bernad, Garófalo, Carmen D’Amelio, Matute, Olga Vega, Puga, Marta Ferrer, Lapresa, María José Goikoetxea, Lasarte, Gabriel Gastaminza, Thinnes, Antonia, Merk, Hans F., Baron, Jens Malte, Leverkus, Martin, Balakirski, Galina, Gibson, Andrew, Ogese, Monday, Al-Attar, Zaid, Yaseen, Fiazia, Meng, Xiaoli, Jenkins, Rozalind, Farrel, John, Alhilali, Khetam, Xue, Yanni, Illing, Patricia, Mifsud, Nicole, Fettke, Heidi, Lai, Jeffrey, Ho, Rebecca, Kwan, Patrick, Purcell, Anthony, Ogese, Monday O., Betts, Catherine, Thomson, Paul, Alhaidari, Mohammad, Berry, Neill, O’Neill, Paul M., Alzahrani, Abdulaziz, Azoury, Marie Eliane, Fili, Lucia, Bechara, Rami, Scornet, Noémie, Nhim, Cathy, Weaver, Richard, Claude, Nancy, Joseph, Delphine, Maillere, Bernard, Parronchi, Paola, Pallardy, Marc, Villani, Axel Patrice, Rozières, Aurore, Bensaïd, Benoît, Tardieu, Mathilde, Albert, Floriane, Mutez, Virginie, Baysal, Tugba, Maryanski, Janet, Nicolas, Jean-François, Kanagawa, Osami, Vocanson, Marc, Hung, Shuen-Iu, Harrison, Caroline J., Jenkins, Rosalind E., French, Neil S., Montañez, Maria Isabel, Fernandez, Tahia D., Martin-Serrano, Angela, Torres, Maria Jose, Molina, Noemi, Wood, Sally, Pirmohamed, Munir, Montañez, María Isabel, Martín-Serrano, Ángela, Pérez-Inestrosa, Ezequiel, Pérez-Sala, Dolores, Guzmán, Antonio E., Ko, Tai-Ming, Chen, Yuan-Tsong, Wu, Jer-Yuarn, Sánchez-Gómez, Francisco J., González-Morena, Juan M., Torres, María J., Arreola, Alejandra Monroy, Corona, Jesus Agustin Badillo, Flores, Silvia Mendez, Cherit, Judith Dominguez, Figueroa, Noe Valentin Duran, Flores, Jose Luis Castrejon, Perkins, James, Pérez-Alzate, Diana, Bogas, Gador, Torres, María J, Marti, Luis Mario Tubella, De La Losa, Fernando Pineda, Poves, Francisca Arribas, Lopez, Jaime Tubella, and Santiago, Teodora Lopez

Abstract

Table of contents Poster walk 11: miscellaneous drug hypersensitivity 2 (P92–P94, P96–P101) P92 16 years of experience with proton pump inhibitors (PPIs) Javier Dionicio Elera, Cosmin Boteanu, Maria Aranzazu Jimenez Blanco, Rosario Gonzalez-Mendiola, Irene Carrasco García, Antonio Alvarez, Jose Julio Laguna Martinez P93 Allergy evaluation of quinolone induced adverse reactions Jaume Martí Garrido, Carla Torán Barona, Carolina Perales Chorda, Ramón López Salgueiro, Miguel Díaz Palacios, Dolores Hernández Fernández De Rojas P94 Bupropion-induced acute urticaria and angioedema, a case report Emre Ali Acar, Ayse Aktas, Aylin Türel Ermertcan, Peyker Temiz P96 Delayed type hypersensitivity and study of cross-reactivity between proton-pump inhibitors Chien-Yio Lin, Chung-Yee Rosaline Hui, Ya-Ching Chang, Chih-Hsun Yang, Wen-Hung Chung P97 Diagnostic work-up in suspected hypersensitivity to proton-pump inhibitors: looking at cross-reactivity Fabrícia Carolino, Diana Silva, Eunice Dias De Castro, Josefina R. Cernadas P98 Management of infusion-related hypersensitivity reactions to enzyme replacement therapy for lysosomal diseases Luis Felipe Ensina, Carolina Aranda, Ines Camelo Nunes, Alex Lacerda, Ana Maria Martins, Ekaterini Goudouris, Marcia Ribeiro, José Francisco Da Silva Franco, Leandra Queiroz, Dirceu Solé P99 Management of insulin allergy with continuous subcutaneous insulin infusion Ceyda Tunakan Dalgiç, Aytül Zerrin Sin, Fatma Düsünür Günsen, Gökten Bulut, Fatma Ömür Ardeniz, Okan Gülbahar, Emine Nihal Mete Gökmen, Ali Kokuludag P100 Off-label use of icatibant for management of serious angioedema associated with angiotensin inhibitors Ana M. Montoro De Francisco, Talía Mª De Vicente Jiménez, Adriana M. Mendoza Parra, Angella M. Burgos Pimentel, Amelia García Luque P101 Thiocolchicoside anaphylaxis: an unusual suspect? Luis Amaral, Fabricia Carolino, Leonor Carneiro Leão, Eunice Castro, Josefina Cernadas Poster walk 12: betalactam hypersensitivity (P102–P111) P102 A curious delayed reading: a case report of a β-lactam allergy in a child Nicole Pinto, Joana Belo, João Marques, Pedro Carreiro-Martins, Paula Leiria-Pinto P103 Betalactam-induced hypersensitivity: a 10-years’ experience Amel Chaabane, Haifa Ben Romdhane, Nadia Ben Fredj, Zohra Chadly, Naceur A. Boughattas, Karim Aouam P104 Cefazolin hypersensitivity: towards optimized diagnosis Astrid P. Uyttebroek, Chris H. Bridts, Antonino Romano, Didier G. Ebo, Vito Sabato P105 Clavulanic acid allergy: two cases report Anabela Lopes, Joana Cosme, Rita Aguiar, Tatiana Lourenço, Maria-João Paes, Amélia Spínola-Santos, Manuel Pereira-Barbosa P106 Diagnosis of betalactam allergy in an allergy department Cíntia Rito Cruz, Rute Pereira Dos Reis, Elza Tomaz, Ana Paula Pires, Filipe Inácio P107 Diagnostic work-up of 410 patients with suspicion of betalactam antibiotic hypersensitivity Filipe Benito-Garcia, Inês Mota, Magna Correia, Ângela Gaspar, Marta Chambel, Susana Piedade, Mário Morais-Almeida P108 Immediate selective hypersensitivity reactions to clavulanic acid Alla Nakonechna, Yurij Antipkin, Tetiana Umanets, Fernando Pineda, Francisca Arribas, Volodymyr Lapshyn P109 Prevalence and incidence of penicillin hypersensitivity reactions in Colombia Pablo Andrés Miranda, Bautista De La Cruz Hoyos P110 Selective sensitization to amoxicilin and clavulanic acid Jose Julio Laguna Martinez, Aranzazu Jimenez Blanco, Javier Dionicio Elera, Cosmin Boteanu, Rosario Gonzalez-Mendiola, Marta Del Pozo P111 Infliximab-specific T cells are detectable also in treated patients who have not developed anti-drug antibodies Alessandra Vultaggio, Francesca Nencini, Sara Pratesi, Andrea Matucci, Enrico Maggi Poster walk 13: biologicals, local anesthetics, others (P112–P118) P112 A case report of allergic immediate systemic reaction to adalimumab and certolizumab Ceyda Tunakan Dalgiç, Fatma Düsünür Günsen, Gökten Bulut, Fatma Ömür Ardeniz, Okan Gülbahar, Emine Nihal Mete Gökmen, Aytül Zerrin Sin, Ali Kokuludag P113 Allergy to local anesthetics: negative predictive value of skin tests Ivana Cegec, Danica Juricic Nahal, Viktorija Erdeljic Turk, Matea Radacic Aumiler, Ksenija Makar Ausperger, Iva Kraljickovic, Iveta Simic P114 Cutaneous adverse reactions of molecular targeted agents: a retrospective analysis in 150 patients in our department Yukie Yamaguchi, Tomoya Watanabe, Megumi Satoh, Tomohiko Tanegashima, Kayoko Oda, Hidefumi Wada, Michiko Aihara P115 Generalized paralysis induced by local lidocaine injection Jaechun Jason Lee, Jay Chol Choi, Hwa Young Lee P116 Hypersensitivity to local anaesthetics: a 10 year review Rosa-Anita Rodrigues Fernandes, Emília Faria, Joana Pita, Nuno Sousa, Carmelita Ribeiro, Isabel Carrapatoso, Ana Todo Bom P117 Local anaesthetics: a rare culprit in hypersensitivity reactions Ana Rodolfo, Eunice Dias-Castro, Josefina Cernadas P118 Stevens–Johnson syndrome in clinical practice: a variant of clinical course Marina Voronova Poster walk 14: RCM (P119–P128) P119 13 cases of severe anaphylactic reactions due to radiocontrast media Jaume Martí Garrido, Ramon Lopez Salgueiro, Diana Kury Valle, Verónica Pacheco Coronel, Carolina Perales Chordá, Dolores Hernandez Fernandez De Rojas P120 Anaphylactic shock after administration of iodinated contrast medium during cardiac catheterization Roselle Catherine Yu Madamba, Marta Ferrer, Maria Jose Goikoetxea, Carmen D’Amelio, Amalia Bernad, Olga Vega, Gabriel Gastaminza P121 Anaphylactic shock and cardiac arrest induced by gadolinium-based contrast agents Beatriz Pola Bibián, Marina Lluncor Salazar, Gemma Vilà Nadal, Ana María Fiandor Roman, Javier Dominguez Ortega, Miguel Gonzalez Muñoz, Santiago Quirce Gancedo, Maria Rosario Cabañas Moreno P122 Anaphylaxis to gadobenate and cross-reactivity to other gadolinium-based contrast agents in two patients Kathrin Scherer Hofmeier P123 Anaphylaxis to glatiramer acetate in a patient with multiple sclerosis Fabrícia Carolino, Vladyslava Barzylovych, Josefina R. Cernadas P124 Delayed hypersensitivity reaction to radiocontrast media Fabrícia Carolino, Diana Silva, Leonor Leão, Josefina R. Cernadas P125 Drug reaction with eosinophilia and systemic symptoms induced by iodixanol Gemma Vilà-Nadal, Beatriz Pola, Marina Lluncor, Ana Fiandor, Teresa Bellón, Javier Domínguez, Santiago Quirce P126 Electronic consultation support system for radiocontrast media hypersensitivity changes clinician’s behavior Min-Suk Yang, Sun-Sin Kim, Sae-Hoon Kim, Hye-Ryun Kang, Heung-Woo Park, Sang-Heon Cho, Kyung-Up Min, Yoon-Seok Chang P127 Hypersensitivity reactions to iodinated contrast media: skin testing and follow-up Danica Juricic Nahal, Ivana Cegec, Viktorija Erdeljic Turk, Iva Kraljickovic, Matea Radacic Aumiler, Ksenija Makar Ausperger, Iveta Simic P128 Would iodine allergy exist? Clémence Delahaye, Jenny Flabbee, Julie Waton, Olivia Bauvin, Annick Barbaud Poster walk 15: MPE/type 4 (P129–P137) P129 Delayed hypersensitivity cutaneous reactions: a case/control study from a tunisian database Karim Aouam, Najah Ben Fadhel, Zohra Chadly, Nadia Ben Fredj, Naceur A. Boughattas, Amel Chaabane P130 Delayed hypersensitivity reactions to cephalosporins: a review of seven cases Joana Cosme, Anabela Lopes, Amélia Spínola-Santos, Manuel Pereira-Barbosa P131 Diclofenac induced allergic contact dermatitis: case series of four patients Sandra Jerkovic Gulin, Anca Chiriac P132 Late-onset maculopapular rash to irbesartan Bárbara Kong Cardoso, Elza Tomaz, Regina Viseu, Filipe Inácio P133 Nonimmediate hypersensitivity reactions to betalactams: a retrospective analysis Ana Moreira, Susana Cadinha, Ana Castro Neves, Patricia Barreira, Daniela Malheiro, J. P. Moreira Da Silva P134 Occupational airborne contact dermatitis to omeprazole Ružica Jurakic-Toncic, Suzana Ljubojevic, Petra Turcic P135 Ornidazole-induced fixed drug eruption confirmed by positive patch test on a residual pigmented lesion Liesbeth Gilissen, Sara Huygens, An Goossens P136 Repeated delayed reaction induced by amoxicillin and amoxicillin clavulanate Inmaculada Andreu, Ramon Lopez-Salgueiro, Alicia Martinez Romero, Pau Gomez Cabezas P137 Systemic photosensitivity from fenofibrate in a patient photo-sensitized to ketoprofen Liesbeth Gilissen, An Goossens Poster walk 16: HLA genetics (P138–P146) P138 A copy number variation in ALOX5 and PTGER1 is associated with nonsteroidal anti-inflammatory drugs induced urticaria and/or angioedema Pedro Ayuso Parejo, Maria Del Carmen Plaza-Serón, Inmaculada Doña, Natalia Blanca López, Carlos Flores, Luisa Galindo, Ana Molina, James Richard Perkins, Jose Antonio Cornejo-García, José Augusto García-Agúndez, Elena García-Martín, Paloma Campo, María Gabriela Canto, Miguel Blanca P139 Association of galectin-3 (LGALS3) single nucleotide polymorphisms with non-steroidal anti-inflammatory drugs-induced urticaria/angioedema José Antonio Cornejo-Garcia, Inmaculada Doña, Rosa María Guéant-Rodríguez, Natalia Blanca-López, María Carmen Plaza-Serón, Raquel Jurado-Escobar, Esther Barrionuevo, María Salas, María Luisa Galindo, Gabriela Canto, Miguel Blanca, Jean-Louis Guéant P140 Detection of T cell responses to ticlopidine using peripheral blood mononuclear cells from HLA-A*33:03+ healthy donors Toru Usui, Arun Tailor, Lee Faulkner, John Farrell, Ana Alfirevic, B. Kevin Park, Dean J. Naisbitt P141 Epistasis approaches to identify novel genes potentially involved in NSAIDs hypersensitivity James Richard Perkins, Jose Antonio Cornejo García, Oswaldo Trelles, Inmaculada Doña, Esther Barrionuevo, María Salas, María Auxiliadora Guerrero, Miguel Blanca, Alex Upton P142 Genetic predisposition of cold medicine related SJS/TEN with severe ocular complications Mayumi Ueta, Hiromi Sawai, Chie Sotozono, Katushi Tokunaga, Shigeru Kinoshita P143 HLA-B*13:01 and dapsone induced hypersensitivity in Thai population Chonlaphat Chonlaphat Sukasem, Patompong Satapornpong, Therdpong Tempark, Pawinee Rerknimitr, Kulprapat Pairayayutakul, Jettanong Klaewsongkram P144 HLA-B*15:02 alleles and lamotrigine-induced cutaneous adverse drug reactions in Thai Chonlaphat Sukasem, N. Koomdee, T. Jantararoungtong, S. Santon, A. Puangpetch, U. Intusoma, W. Tassaneeyakul, V. Theeramoke P145 HLA-B*38:01 and HLA-A*24:02 allele frequencies in Spanish patients with lamotrigine-induced SCARs Teresa Bellón, Elena Ramirez, Alberto Manuel Borobia, Hoi Tong, Jose Luis Castañer, Francisco José De Abajo P146 Overrepresentation of a class II HLA haplotype in severe hypersensitivity type I reactions to carboplatin Violeta Régnier Galvao, Rebecca Pavlos, Elizabeth Mckinnon, Kristina Williams, Alicia Beeghly-Fadiel, Alec Redwood, Elizabeth Phillips, Mariana Castells Poster walk 17: in vivo diagnosis + sIgE (P147–P154) P147 Absence of specific Ig-e against beta-lactams 9 months after an allergic reaction to amoxicillin-clavulanic acid Elisa Boni, Marina Russello, Marina Mauro P148 Drug provocation tests in suspected opioid allergy Kok Loong Ue, Krzysztof Rutkowski P149 Improvement to the specific IgE cut-off in the assess of β-lactamic allergy Victor Soriano Gomis, Jorge Frances Ferre, Angel Esteban Rodriguez, Vicente Cantó Reig, Javier Fernandez Sanchez P150 Initial false negative specific IgE to gelatin in a patient with gelatin-induced anaphylaxis Christine Breynaert, Erna Van Hoeyveld, Rik Schrijvers P151 Inmediate reactions to beta-lactam antibiotics: pattern of skin test response over the time Jose Julio Laguna Martinez, Rosario Gonzalez Mendiola, Javier Dionicio Elera, Cosmin Boteanu, Aranzazu Jimenez Blanco, Marta Del Pozo, Raquel Fuentes Irigoyen P152 New fluorescent dendrimeric antigens for the evaluation of dendritic cell maturation as a test to detect allergy reactions to amoxicillin Daniel Collado, Yolanda Vida, Francisco Najera, Ezequiel Perez-Inestrosa, Pablo Mesa-Antunez, Cristobalina Mayorga, María José Torres, Miguel Blanca P153 Positive skin test or positive specific IgE to penicillin does not predict penicillin allergy Line K. Tannert, Charlotte G. Mortz, Per Stahl Skov, Carsten Bindslev-Jensen P154 Significance of skin testing and in vitro-analysis of neuromuscular blocking agents in diagnosis of perioperative drug hypersensitivity: evaluation of a negative control population Wolfgang Pfützner, Hannah Dörnbach, Johanna Visse, Michele Rauber, Christian Möbs Poster walk 18: in vitro/ex vivo (P155–P158, P160–P164) P155 Diagnostic value of the lymphocyte toxicity assay (LTA) and the in vitro platelet toxicity assay (IPTA) for β-lactam allergy Abdelbaset A. Elzagallaai, Lindsey Chow, Awatif M. Abuzgaia, Michael J. Rieder P156 Enzyme linked immunospot assay used in the diagnosis of severe cutaneous adverse reactions to antimicrobials Alec Redwood, Jason Trubiano, Rebecca Pavlos, Emily Woolnough, Kaija Stautins, Christina Cheng, Elizabeth Phillips P157 Evaluation of in vitro diagnostic methods for identifying the culprit drugs in drug hypersensitivity Kenichi Kato, Hiroaki Azukizawa, Takaaki Hanafusa, Ichiro Katayama P158 Ex-vivo expanded skin-infiltrating T cells from severe drug eruptions are reactive with causative drugs: a possible novel method for determination of causative drugs Toshiharu Fujiyama, Hideo Hashizume, Takatsune Umayahara, Taisuke Ito, Yoshiki Tokura P160 In vitro release of IL-2, IL-5 and IL-13 in diagnosis of patients with delayed-type nickel hypersensitivity Mira Silar, Mihaela Zidarn, Helena Rupnik, Peter Korosec P161 Single cell analysis of drug responsive T cells; identification of candidate drug reactive T cell receptors in abacavir and carbamazepine hypersensitivity Alec James Redwood, Kaija Strautins, Katie White, Abha Chopra, Katherine Konvinse, Shay Leary, Rebecca Pavlos, Simon Mallal, Elizabeth Phillips P162 Specificity and sensitivity of LTT in DRESS: analysis of agreement with the Spanish pharmacovigilance system probability algorithm Rosario Cabañas, Elena Ramirez, Ana María Fiandor, Teresa Bellón P163 The role of interleukin-22 in β-lactam hypersensitivity Andrew Sullivan, Paul Whitaker, Daniel Peckham, B. Kevin Park, Dean J. Naisbitt P164 Vancomycin-specific T cell responses and teicoplanin cross-reactivity Wei Yann Haw, Marta E. Polak, Carolann Mcguire, Michael R. Ardern-Jones Poster walk 19: BAT and biomarkers (P165–P173) P165 A combination of early biomarkers useful for the prediction of severe ADRs Yumi Aoyama, Tetsuo Shiohara P166 Basophil activation test in the diagnostic approach of reactions during general anaesthesia Ana Moreira, Susana Cadinha, Patrícia Barreira, Ana Castro Neves, Daniela Malheiro, Sara Correia, J. P. Moreira Da Silva P167 IL-10 can be related to successful desensitization Asli Gelincik, Semra Demir, Fatma Sen, Hamza Ugur Bozbey, Muge Olgac, Derya Unal, Raif Coskun, Bahauddin Colakoglu, Suna Buyuozturk, Esin Çatin-Aktas, Gunnur Deniz P168 Immediate reactions to proton pump inhibitors: value of basophil activation test Maria Salas, Jose Julio Laguna, Esther Barrionuevo, J. Dionicio, Tahia Fernandez, R. Gonzalez-Mendiola, I. Olazabal, Maria Dolores Ruiz, Miguel Blanca, Cristobalina Mayorga, Maria José Torres P169 Improvement of the elevated tryptase criterion to discriminate IgE from non-IgE mediated allergic reactions Gabriel Gastaminza, Alberto Lafuente, Carmen D’Amelio, Amalia Bernad, Olga Vega, Roselle Catherine Madamba, M. Jose Goikoetxea, Marta Ferrer, Jorge Núñez P170 Low expression of Tim-3 could serve as a biomarker for control and diagnose maculopapular exanthema induced by drugs Tahia Diana Fernández, Inmaculada Doña, Francisca Palomares, Rubén Fernández, Maria Salas, Esther Barrionuevo, Maria Isabel Sanchez, Miguel Blanca, Maria José Torres, Cristobalina Mayorga P171 Role of basophil activation test using two different activation markers for the diagnosis of allergy to fluoroquinolones Esther Barrionuevo, Tahía Fernandez, Arturo Ruiz, Adriana Ariza, Maria Salas, Inmaculada Doña, Ana Molina, Miguel Blanca, Maria Jose Torres, Cristobalina Mayorga P172 The importance of basophil activation test in anaphylaxis due to celecoxib Amalia Bernad Alonso, Carmen D’Amelio Garófalo, Olga Vega Matute, Marta Ferrer Puga, María José Goikoetxea Lapresa, Roselle Catherine Yu Madamba, Gabriel Gastaminza Lasarte P173 The role of basophil activation test in the diagnosis of immediate type drug hypersensitivity to betalactam antibiotics Antonia Thinnes, Hans F. Merk, Jens Malte Baron, Martin Leverkus, Galina Balakirski Poster walk 20: TCR recognition, cellular (P174–P183) P174 Characterisation of the effect of co-inhibitory signalling on the activation of drug-derived antigen-specific T-cells Andrew Gibson, Monday Ogese, Lee Faulkner, B. Kevin Park, Dean J. Naisbitt P175 Characterization of drug hapten-specific T cell responses in piperacillin hypersensitive patients Zaid Al-Attar, Fiazia Yaseen, Xiaoli Meng, Rozalind Jenkins, Paul Whitaker, Daniel Peckham, Lee Faulkner, John Farrel, Kevin Park, Dean Naisbitt P176 Characterization of the response of T-cells to telaprevir and its metabolite in normal volunteers Zaid Al-Attar, Khetam Alhilali, Yanni Xue, John Farrell, Lee Faulkner, Kevin Park, Dean Naisbitt P177 Characterization of the T cell receptor signatures of drug-responsive T cells Patricia Illing, Nicole Mifsud, Heidi Fettke, Jeffrey Lai, Rebecca Ho, Patrick Kwan, Anthony Purcell P178 Defining the signals between hepatocytes and immune cells in idiosyncratic drug-induced liver injury (DILI) Monday O. Ogese, Lee Faulkner, B. Kevin Park, Catherine Betts, Dean J. Naisbitt P179 Development of novel chemicals that do not bind to HLA-B*57:01 or activate CD8 + T-cells through modification of the 6-amino cyclopropyl group of abacavir Paul Thomson, John Farrell, Mohammad Alhaidari, Neill Berry, Paul M. O’Neill, B. Kevin Park, Dean J. Naisbitt P180 Generation and characterization of dapsone- and nitroso-dapsone-specific T-cell clones using lymphocytes from healthy volunteers Abdulaziz Alzahrani, Monday O. Ogese, John Farrell, Lee Faulkner, Andrew Gibson, Arun Tailor, B. Kevin Park, Dean J. Naisbitt P181 Identification of benzylpenicillin-hapten peptides responsible for naïve T-cell activation and immunization of allergic patients to penicillin Marie Eliane Azoury, Lucia Fili, Rami Bechara, Noémie Scornet, Cathy Nhim, Richard Weaver, Nancy Claude, Delphine Joseph, Bernard Maillere, Paola Parronchi, Marc Pallardy P182 Massive expansion of clonotypic and polycytotoxic CD8+ T cells in toxic epidermal necrolysis Axel Patrice Villani, Aurore Rozières, Benoît Bensaïd, Mathilde Tardieu, Floriane Albert, Virginie Mutez, Tugba Baysal, Marc Pallardy, Janet Maryanski, Jean-François Nicolas, Osami Kanagawa, Marc Vocanson P183 Pharmaco-immunological synapse of HLA-drug-TCR in SCAR Shuen-Iu Hung Poster walk 21: new in vitro methods, haptens, etc. (P184–P194) P184 Amoxicillin-clavulanate forms distinct multiple haptenic structures on human serum albumin in patients Xiaoli Meng, Arun Tailor, Caroline J. Harrison, Rosalind E. Jenkins, Paul Whitaker, Neil S. French, Dean J. Naisbitt, B. Kevin Park P185 Dendrimeric antigens for studying the influence of penicillin determinants orientation on IgE recognition Maria Isabel Montañez, Cristobalina Mayorga, Francisco Najera, Adriana Ariza, Tahia D. Fernandez, Maria Salas, Angela Martin-Serrano, Miguel Blanca, Ezequiel Perez-Inestrosa, Maria Jose Torres P186 Dendrimeric antigens on solid supports: designed materials for IgE quantification Yolanda Vida, Maria Isabel Montañez, Noemi Molina, Daniel Collado, Francisco Najera, Adriana Ariza, Maria Jose Torres, Cristobalina Mayorga, Ezequiel Perez-Inestrosa P187 Development of a screening assay for drug hypersensitivity using naïve T cells from donors with seven different HLA class I risk alleles Lee Faulkner, Sally Wood, Ana Alfirevic, Munir Pirmohamed, Dean J. Naisbitt, B. Kevin Park P188 Different patterns of recognition of structures derived from amoxicillin by IgE antibodies from patients with immediate hypersensitivity reactions to betalactams Adriana Ariza, Cristobalina Mayorga, María Isabel Montañez, María Salas, Inmaculada Doña, Ángela Martín-Serrano, Ezequiel Pérez-Inestrosa, Dolores Pérez-Sala, Miguel Blanca, Antonio E. Guzmán, María José Torres P189 High-resolution typing of HLA polymorphism and T-cell receptor repertoire for severe adverse drug reactions based on the cost-effective next-generation sequencing approaches Tai-Ming Ko, Yuan-Tsong Chen, Jer-Yuarn Wu P190 Identification and fate of intracellular proteins haptenated by amoxicillin Francisco J. Sánchez-Gómez, Juan M. González-Morena, Yolanda Vida, Ezequiel Pérez-Inestrosa, Miguel Blanca, María J. Torres, Dolores Pérez-Sala P191 In vitro detection of terbinafine protein adducts Arun Tailor, Toru Usui, Yanni Xue, Xiaoli Meng, Dean J. Naisbitt, B. Kevin Park P192 MicroRNAs dysregulation in PBMCs from drug hypersensitivity patients during drug challenge in vitro Alejandra Monroy Arreola, Jesus Agustin Badillo Corona, Silvia Mendez Flores, Judith Dominguez Cherit, Dean J. Naisbitt, Noe Valentin Duran Figueroa, Jose Luis Castrejon Flores P193 NSAIDs-exacerbated cutaneous disease: high throughput gene expression profiling José Antonio Cornejo-García, James Perkins, Natalia Blanca-López, Diana Pérez-Alzate, Raquel Jurado-Escobar, Inmaculada Doña, Gador Bogas, María J. Torres, Gabriela Canto, Miguel Blanca P194 Utility of skin tests in non-immediate reactions to amoxicillin Luis Mario Tubella Marti, Fernando Pineda De La Losa, Francisca Arribas Poves, Jaime Tubella Lopez, Teodora Lopez Santiago

Published
2016
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42. Treatment of Chronic Myeloid Leukemia Elderly Patients in the Tyrosine Kinase Inhibitor Era

Author

Russo, Domenico, Malagola, Michele, Skert, Cristina, Filì, Carla, Bergonzi, Cesare, Cancelli, Valeria, and Cattina, Federica

Abstract

The prevalence of chronic myeloid leukemia (CML) is expected to double in the next 15 years. The introduction of imatinib significantly changed the prognosis of CML, challenging the concept of a fatal disease. Nowdays, imatinib, nilotinib and dasatinib are registered for first-line treatment of CML patients in chronic phase (CP). Considering elderly patients, the most extensively studied TKI is imatinib, that induces a rate of cytogenetic and molecular responses comparable between the younger and the elderly patients. Once a CCgR with imatinib is achieved, the probability to be alive and disease free at 8 years is more than 80. These results confirm that imatinib has to be considered the first-line treatment for the elderly and that the CCgR is the guide parameter for treatment modulation and the most solid marker of long term outcome. Nevertheless, older patients tolerate imatinib worse in comparison to the younger, and this causes a higher rate of therapy discontinuation and less adherence to chronic treatment. Thus, the toxic profile of each TKI is one of the most important factors driving the choice of the best drug. Another important factor is the potency of the TKI. Since nilotinib and dasatinib are more potent than imatinib in inducing cytogenetic and molecular responses, they could be preferred for increasing the proportion of patients who can achieve deeper molecular responses, allowing treatment discontinuation. This approach is intriguing, but it is still experimental. Another therapeutic strategy could be the identification of the minimal effective dose of TKI in order to maintain the CCgR, but also this approach is under clinical investigation.

Published
2013

43. The Role of Etanercept on the Expression of Markers of T Helper 17 Cells and Their Precursors in Skin Lesions of Patients with Psoriasis Vulgaris

Author

Antiga, E., Volpi, W., Chiarini, C., Cardilicchia, E., Filì, L., Manuelli, C., Parronchi, P., Fabbri, P., and Caproni, M.

Abstract

Very recently, it has been demonstrated that CD161, retinoic acid—related orphan receptor γt (RORγt) and CC-chemokin receptor 6 (CCR6) can be considered good surface markers to detect T helper 17 cells and their precursors, T cell populations that are considered to play an important role in the pathogenesis of psoriasis. In the present study, we evaluate the clinical involvement by calculating the PASI score and the number of CD4+, CD161+, RORγt+ and CCR6+ cells before and after a 12-week course with etanercept or acitretin in patients with moderate-to-severe, plaque-type psoriasis vulgaris. Ten patients were given etanercept 50 mg twice weekly and 10 patients acitretin 0.4 mg/kg per day, both for 12 weeks. At the baseline and at the end of the treatment PASI was calculated, and skin biopsies were taken to evaluate the expression of CD4, CD161, RORyt and CCR6 by immunohistochemistry. As controls, 10 patients with atopic dermatitis (AD) were included in the study. After 12 weeks, PASI was significantly lower than at the baseline for both groups. However, etanercept-treated patients showed lower PASI than acitretin-treated ones. While CD4+ cell numbers were similar in both diseases, all the other markers, that are considered more specific for Th17 cells and their precursors, were more expressed in psoriasis than in AD. Furthermore, only etanercept, but not acitretin, was able to significantly reduce CD161+, RORγt+ and CCR6+ cells in skin lesions of patients with psoriasis. Our study provides further evidence of the role of Th17 pathway in the pathogenesis of psoriasis. Furthermore, our findings suggest that etanercept is able to downregulate the expression of the recently recognized markers of Th17 cells and their precursors CD161, RORγt and CCR6, while acitretin is not. This activity on the Th17 lineage may contribute to the efficacy of etanercept in the treatment of psoriasis.

Published
2010
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44. Clinical Burden of Screening Asymptomatic Patients for Coronary Artery Disease Prior to Liver Transplantation

Author

Filì, D., Vizzini, G., Biondo, D., Pietrosi, G., Volpes, R., Palazzo, U., D’Antoni, A., Petridis, I., Luca, A., and Gridelli, B.

Abstract

The aim of this study is to assess the clinical burden of silent coronary artery disease (CAD) in cirrhotic candidates for liver transplantation (LT), and to evaluate the usefulness of a CAD screening approach. Between July 1999 and January 2006, we evaluated 627 LT candidates. All of them underwent a detailed clinical history. Sixteen had a previous diagnosis of CAD or symptoms suggestive (2.5%). The remaining 611 underwent further tests according to a predefined protocol, including EKG, echocardiogram and, on the basis of CAD risk factors, heart stress tests. Selective coronary angiography (SCA) was performed in the 30 patients with positive heart stress test: in only 2 did SCA show any CAD, and in both it was subcritical disease requiring neither intervention nor contraindicating LT. The 611 screened patients continued their follow-up until study closure or death. No coronary events occurred in the study population in a mean follow-up of 32.50 months (+/−23.67 DS). No perioperative mortality related to CAD occurred in the 233 transplanted patients. In conclusion, no prognostic advantage was achieved by following a strict CAD screening protocol, leading us to believe that the cost-effectiveness of a similar screening can be unacceptably high in our setting.

Published
2009
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45. Confronto tra miscele di erbicidi per il controllo della flora infestante del frumento duro

Author

Perniola, Michele, Lovelli, Stella, Di Tommaso, Teodoro, Caponio, Tommaso, and Filì, Vittorio

Abstract

Al fine di ampliare le possibilità di rotazione nell'uso di molecole erbicide si è voluto saggiare l'efficacia di azione di una nuova molecola, il pinoxaden, rispetto a quella di altri erbicidi comunemente impiegati per il diserbo del frumento duro.

Published
2008
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46. Abdominal abscess and Hafnia alveisepticemia occurring during the aplastic phase after autologous stem-cell transplantation in a patient with diffuse large B-cell lymphoma

Author

Candoni, Anna, Filì, Carla, Tiribelli, Mario, Fanin, Renato, and Trevisan, Roberto

Abstract

Hafnia alveiis a motile gram-negative bacterium that is rarely isolated from human specimens, but that sometimes can be found as part of the gastrointestinal flora. Here we report a rare case of Hafnia alveisepticemia with an abdominal abscess in a 60-year-old woman with diffuse large B-cell lymphoma involving the spleen, liver, and then lymph nodes. She initially received a splenectomy, and, over a 2-year period, four courses of chemotherapy. After achieving complete remission status, she underwent autologous peripheral blood stem-cell transplantation (PBSCT). During the aplastic phase following transplantation, the patient developed fever, diarrhea, and abdominal pain, with blood cultures positive for Hafnia alveiand an abscess in the splenic recess. Considering the high surgical risk, the infection was treated, successfully, with antibiotics (imipenem/cilastatin), without surgery or computed tomography (CT)-guided percutaneous drainage. Infections due to Hafnia alveiare rare, and this is the first reported case of Hafnia alveisepticemia in an adult hematologic patient undergoing a stem-cell transplantation procedure.

Published
2004
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49. Efficacy and Safety of Decitabine As First-Line Therapy for Elderly Patients with Acute Myeloid Leukemia.a Real Life Multicentric Experience of the Northern Italy

Author

Borlenghi, Erika, Filì, Carla, Basilico, Claudia, Bernardi, Massimo, Caizzi, Manuela, Ciancia, Rosanna, Di Bona, Eros, Ermacora, Anna, Facchinelli, Davide, Fracchiolla, Nicola, Fumagalli, Monica, Gottardi, Michele, Imbergamo, Silvia, Lambertenghi, Daniela, Molteni, Alfredo, Petullà, Marta, Riva, Marta, Todisco, Elisabetta, Rossi, Giuseppe, and Candoni, Anna

Abstract

Introduction:Decitabine has been recently approved in Europe for treatment of AML patients (pts) aged more than 65 years and unfit to receive standard chemotherapy. However data on its efficacy and tolerability derive mainly from clinical trials performed in selected pts. Herein we report on a population based series of AML pts treated with decitabine and registered in observational prospective studies.

Published
2017
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50. A Gene Panel NGS-Based Strategy for Genomic Characterization of Acute Myeloid Leukemias (AMLs)

Author

Bernardi, Simona, Cattina, Federica, Di Palma, Andrea, Borlenghi, Erika, Schieppati, Francesca, Perucca, Simone, Cancelli, Valeria, Turra, Alessandro, Malagola, Michele, Skert, Crisitina, Filì, Carla, Cattaneo, Chiara, Passi, Angela, Farina, Mirko, Rossi, Giuseppe, Mignone, Flavio, and Russo, Domenico

Abstract

No relevant conflicts of interest to declare.

Published
2015
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