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243 results on '"Figorilli, Michela"'

2. Validation of the International REM Sleep Behavior Disorder Study Group Symptoms Severity Scale (IRBD-SSS): a new tool to assess RBD clinical severity

Author

Fantini, Maria Livia, Postuma, Ronald B., Puligheddu, Monica, Rieu, Isabelle, Venel, Enguerrand, Figorilli, Michela, Cochen-DeCock, Valerie, Leclair-Visonneau, Laurene, Arnaldi, Dario, Mattioli, Pietro, Peter-Derex, Laure, Ricordeau, François, Terzaghi, Michele, Arnulf, Isabelle, Stefani, Ambra, Videnovic, Aleksandar, Chirol, Coline, and Pereira, Bruno

Published
2024
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4. Clinical characteristics of a large cohort of patients with narcolepsy candidate for pitolisant: a cross-sectional study from the Italian PASS Wakix® Cohort

Author

Mutti, Carlotta, Brunetti, Valerio, Figorilli, Michela, Liguori, Claudio, Pizza, Fabio, Proserpio, Paola, Sacco, Tommaso, Pedrazzi, Giuseppe, Lecomte, Isabelle, Blanchard, Nora, Agostoni, Elio Clemente, Bonanni, Enrica, Centonze, Diego, Cicolin, Alessandro, Della Marca, Giacomo, Ferini-Strambi, Luigi, Ferri, Raffaele, Gigli, Gian Luigi, Izzi, Francesca, Liguori, Rocco, Lodi, Raffaele, Nobili, Lino, Parrino, Liborio, Placidi, Fabio, Puligheddu, Monica, Romigi, Andrea, Savarese, Maria Antonietta, Terzaghi, Michele, and Plazzi, Giuseppe

Published
2022
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8. Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects

Author

Krohn, Lynne, Heilbron, Karl, Blauwendraat, Cornelis, Reynolds, Regina H., Yu, Eric, Senkevich, Konstantin, Rudakou, Uladzislau, Estiar, Mehrdad A., Gustavsson, Emil K., Brolin, Kajsa, Ruskey, Jennifer A., Freeman, Kathryn, Asayesh, Farnaz, Chia, Ruth, Arnulf, Isabelle, Hu, Michele T. M., Montplaisir, Jacques Y., Gagnon, Jean-François, Desautels, Alex, Dauvilliers, Yves, Gigli, Gian Luigi, Valente, Mariarosaria, Janes, Francesco, Bernardini, Andrea, Högl, Birgit, Stefani, Ambra, Ibrahim, Abubaker, Šonka, Karel, Kemlink, David, Oertel, Wolfgang, Janzen, Annette, Plazzi, Giuseppe, Biscarini, Francesco, Antelmi, Elena, Figorilli, Michela, Puligheddu, Monica, Mollenhauer, Brit, Trenkwalder, Claudia, Sixel-Döring, Friederike, Cochen De Cock, Valérie, Monaca, Christelle Charley, Heidbreder, Anna, Ferini-Strambi, Luigi, Dijkstra, Femke, Viaene, Mineke, Abril, Beatriz, Boeve, Bradley F., Scholz, Sonja W., Ryten, Mina, Bandres-Ciga, Sara, Noyce, Alastair, Cannon, Paul, Pihlstrøm, Lasse, Nalls, Mike A., Singleton, Andrew B., Rouleau, Guy A., Postuma, Ronald B., and Gan-Or, Ziv

Published
2022
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11. Sex Differences in Elderly People's Sleep: A Cross-Sectional Study.

Author

Salis, Francesco, Belfiori, Maristella, Figorilli, Michela, Mulas, Martina, Puligheddu, Monica, and Mandas, Antonella

Subjects
SLEEP quality, OLDER people, GERIATRICS, LOGISTIC regression analysis, COGNITION disorders, EPWORTH Sleepiness Scale
Abstract

Background and Objectives: Sex differences are unclear in geriatric sleep medicine, and most evidence comes from inference from preclinical bases or clinical studies conducted on younger people. The aim of this study is to explore sex differences in sleep quality and daytime sleepiness in a cohort of elderly people. Materials and Methods: This cross-sectional study involved subjects aged 65 years or older undergoing multidimensional evaluation, including sleep quality and daytime sleepiness assessment with validated tools. Results: This study included 226 subjects (69.5% women), the majority of whom showed poor sleep quality (64.2%). A logistic regression model put one before the other sleep quality and gender. It initially showed that men were about half likely as women to have poor sleep quality (OR 0.48, 95%CI 0.27–0.86). Nonetheless, after adjusting for cognitive status and mood, the difference became smaller and insignificant (OR 0.72, 95%CI 0.38–1.38). Conclusions: Sex differences in elderly people's sleep quality seem to not be independent, appearing to be affected by alterations in cognitive status and mood. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Nightshift Rotation Schedule and Fatigue in U.K. and Italian Nurses.

Author

LECCA, ROSAMARIA, WESTWELL, ALISON, CASAGLIA, ELISA, FIGORILLI, MICHELA, MURPHY, ELIZABETH, PULIGHEDDU, MONICA, VAN TONGEREN, MARTIE, and COCCO, PIERLUIGI

Abstract

Background: Whether hours on shift might impact adaptation to night shift work is still controversial. Methods: We conducted a pooled analysis of two studies, including 170 hospital nurses working night shifts, 116 from a United Kingdom study working 12-hour rotating shifts, and 54 from Italy working 8-hour shifts. Both studies used the Epworth Sleepiness Scale (ESS) to detect sleepiness during routine daytime activities as an indicator of fatigue. We compared the prevalence of daytime sleepiness, as indicated by an ESS score≥11, resulting from either shift work schedule. We used logistic regression to calculate the risk of daytime sleepiness associated with 12-hour vs. 8-hour nightshifts, adjusting by age, sex, and parenting children aged≤4. Results: When comparing similar work circumstances, nightshifts prolonged to 12 hours did not increase the risk of daytime sleepiness compared to 8 hours (OR=0.9, 95% CI 0.32, 2.59). Conclusions: Our results suggest that 12-hour rotating nightshifts with additional rest days and 8-hour rotating shift schedules do not differ in their impact on daytime sleepiness. Further research is warranted on what strategies might effectively contrast fatigue, circadian misalignment, and the related metabolic changes leading to adverse health outcomes, including cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Characterization of Sleep Structure and Autonomic Dysfunction in REM Sleep Behavior Disorder

Author

Mandas, Nicla, primary, Mollura, Maximiliano, additional, Baldazzi, Giulia, additional, Sattar, Parisa, additional, Mura, Maria, additional, Casaglia, Elisa, additional, Figorilli, Michela, additional, Giorgetti, Laura, additional, Mattioli, Pietro, additional, Calizzano, Francesco, additional, Famà, Francesco, additional, Arnaldi, Dario, additional, Puligheddu, Monica, additional, Pani, Danilo, additional, and Barbieri, Riccardo, additional

Published
2024
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20. Novel Associations of BST1 and LAMP3 with Rapid Eye Movement Sleep Behavior Disorder

Author

Mufti, Kheireddin, Yu, Eric, Rudakou, Uladzislau, Krohn, Lynne, Ruskey, Jennifer A., Asayesh, Farnaz, Laurent, Sandra B., Spiegelman, Dan, Arnulf, Isabelle, Hu, Michele T.M., Montplaisir, Jacques Y., Gagnon, Jean-François, Desautels, Alex, Dauvilliers, Yves, Gigli, Gian Luigi, Valente, Mariarosaria, Janes, Francesco, Bernardini, Andrea, Högl, Birgit, Stefani, Ambra, Holzknecht, Evi, Sonka, Karel, Kemlink, David, Oertel, Wolfgang, Janzen, Annette, Plazzi, Giuseppe, Antelmi, Elena, Figorilli, Michela, Puligheddu, Monica, Mollenhauer, Brit, Trenkwalder, Claudia, Sixel-Döring, Friederike, De Cock, Valérie Cochen, Monaca, Christelle Charley, Heidbreder, Anna, Ferini-Strambi, Luigi, Dijkstra, Femke, Viaene, Mineke, Abril, Beatriz, Boeve, Bradley F., Trempe, Jean-François, Rouleau, Guy A., Postuma, Ronald B., and Gan-Or, Ziv

Published
2021
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23. GBA variants in REM sleep behavior disorder: A multicenter study

Author

Krohn, Lynne, Ruskey, Jennifer A., Rudakou, Uladzislau, Leveille, Etienne, Asayesh, Farnaz, Hu, Michele T.M., Arnulf, Isabelle, Dauvilliers, Yves, Högl, Birgit, Stefani, Ambra, Monaca, Christelle Charley, Abril, Beatriz, Plazzi, Giuseppe, Antelmi, Elena, Ferini-Strambi, Luigi, Heidbreder, Anna, Boeve, Bradley F., Espay, Alberto J., De Cock, Valérie Cochen, Mollenhauer, Brit, Sixel-Döring, Friederike, Trenkwalder, Claudia, Sonka, Karel, Kemlink, David, Figorilli, Michela, Puligheddu, Monica, Dijkstra, Femke, Viaene, Mineke, Oertel, Wolfgang, Toffoli, Marco, Gigli, Gian Luigi, Valente, Mariarosaria, Gagnon, Jean-François, Desautels, Alex, Montplaisir, Jacques Y., Postuma, Ronald B., Rouleau, Guy A., and Gan-Or, Ziv

Published
2020
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25. Strained face during sleep in multiple system atrophy: not just a bad dream

Author

Lecca, Rosamaria, primary, Figorilli, Michela, additional, Bouniol, Emma, additional, Marques, Ana, additional, Pereira, Bruno, additional, Derost, Philippe, additional, Debilly, Bérangère, additional, Ferri, Raffaele, additional, Puligheddu, Monica, additional, Durif, Franck, additional, and Fantini, Maria Livia, additional

Published
2023
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26. Identifying Neurobiological Markers in Obsessive–Compulsive Disorder: A Study Protocol for a Cross-Sectional Study in Subgroups of Differing Phenotype

Author

Paribello, Pasquale, primary, Carpiniello, Bernardo, additional, Murgia, Roberto, additional, Porcheddu, Antonio Andrea, additional, El-Kacemi, Sabrina, additional, Pinna, Marco, additional, Contu, Martina, additional, Costa, Giulia, additional, Barbarossa, Rossella, additional, Sanna, Egea, additional, Carucci, Sara, additional, Zuddas, Alessandro, additional, Fadda, Paola, additional, Dedoni, Simona, additional, Siddi, Carlotta, additional, Congiu, Patrizia, additional, Figorilli, Michela, additional, Fanzecco, Michela, additional, Puligheddu, Monica, additional, Gagliano, Antonella, additional, Pinna, Federica, additional, Scherma, Maria, additional, and Manchia, Mirko, additional

Published
2023
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27. Oligomeric Alpha-Synuclein and STX-1A from Neural-Derived Extracellular Vesicles (NDEVs) as Possible Biomarkers of REM Sleep Behavior Disorder in Parkinson’s Disease: A Preliminary Cohort Study

Author

Meloni, Mario, primary, Agliardi, Cristina, additional, Guerini, Franca Rosa, additional, Saibene, Francesca Lea, additional, Milner, Anna Vera, additional, Zanzottera, Milena, additional, Bolognesi, Elisabetta, additional, Puligheddu, Monica, additional, Figorilli, Michela, additional, Navarro, Jorge, additional, and Clerici, Mario, additional

Published
2023
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29. Considering REM Sleep Behavior Disorder in the Management of Parkinson’s Disease

Author

Figorilli,Michela, Meloni,Mario, Lanza,Giuseppe, Casaglia,Elisa, Lecca,Rosamaria, Saibene,Francesca Lea, Congiu,Patrizia, Puligheddu,Monica, Figorilli,Michela, Meloni,Mario, Lanza,Giuseppe, Casaglia,Elisa, Lecca,Rosamaria, Saibene,Francesca Lea, Congiu,Patrizia, and Puligheddu,Monica

Abstract

Michela Figorilli,1 Mario Meloni,2 Giuseppe Lanza,3,4 Elisa Casaglia,1 Rosamaria Lecca,1 Francesca Lea Saibene,2 Patrizia Congiu,1 Monica Puligheddu1 1Sleep Disorder Research Center, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy; 2IRCCS, Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy; 3Department of Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy; 4Clinical Neurophysiology Research Unit, Oasi Research Institute-IRCCS, Troina, ItalyCorrespondence: Monica Puligheddu, Sleep Disorder Research Center, Department of Medical Sciences and Public Health, SS 554 Km 4500, 09042 Monserrato CA, Cagliari, Italy, 09042, Tel +07051096001, Email puligheddu@unica.itAbstract: Rapid eye movement (REM) sleep behavior disorder (RBD) is the result of the loss of physiological inhibition of muscle tone during REM sleep, characterized by dream-enacting behavior and widely recognized as a prodromal manifestation of alpha-synucleinopathies. Indeed, patients with isolated RBD (iRBD) have an extremely high estimated risk to develop a neurodegenerative disease after a long follow up. Nevertheless, in comparison with PD patients without RBD (PDnoRBD), the occurrence of RBD in the context of PD (PDRBD) seems to identify a unique, more malignant phenotype, characterized by a more severe burden of disease in terms of both motor and non-motor symptoms and increased risk for cognitive decline. However, while some medications (eg, melatonin, clonazepam, etc.) and non-pharmacological options have been found to have some therapeutic benefits on RBD there is no available treatment able to modify the disease course or, at least, slow down the neurodegenerative process underlying phenoconversion. In this scenario, the long prodromal phase may allow an early therapeutic window and, therefore, the identification of multimodal biomarkers of disease onset and progression is becoming increasingly crucial. To date, several clinical (mot

Published
2023

30. Clinical and dopaminergic imaging characteristics of the FARPRESTO cohort of trial‐ready idiopathic rapid eye movement sleep behavior patients.

Author

Arnaldi, Dario, Mattioli, Pietro, Pardini, Matteo, Morbelli, Silvia, Capriglia, Elena, Rubino, Annalisa, Rustioni, Valter, Terzaghi, Michele, Casaglia, Elisa, Serra, Alessandra, Figorilli, Michela, Liguori, Claudio, Fernandes, Mariana, Placidi, Fabio, Baldelli, Luca, Provini, Federica, Ferini‐Strambi, Luigi, Marelli, Sara, Plazzi, Giuseppe, and Antelmi, Elena

Subjects
RAPID eye movement sleep, DOPAMINERGIC imaging, DIAGNOSTIC imaging, HYPERSOMNIA
Abstract

Introduction: Idiopathic/isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is considered the prodromal stage of alpha‐synucleinopathies. Thus, iRBD patients are the ideal target for disease‐modifying therapy. The risk FActoRs PREdictive of phenoconversion in iRBD Italian STudy (FARPRESTO) is an ongoing Italian database aimed at identifying risk factors of phenoconversion, and eventually to ease clinical trial enrollment of well‐characterized subjects. Methods: Polysomnography‐confirmed iRBD patients were retrospectively and prospectively enrolled. Baseline harmonized clinical and nigrostriatal functioning data were collected at baseline. Nigrostriatal functioning was evaluated by dopamine transporter‐single‐photon emission computed tomography (DaT‐SPECT) and categorized with visual semi‐quantification. Longitudinal data were evaluated to assess phenoconversion. Cox regressions were applied to calculate hazard ratios. Results: 365 patients were enrolled, and 289 patients with follow‐up (age 67.7 ± 7.3 years, 237 males, mean follow‐up 40 ± 37 months) were included in this study. At follow‐up, 97 iRBD patients (33.6%) phenoconverted to an overt synucleinopathy. Older age, motor and cognitive impairment, constipation, urinary and sexual dysfunction, depression, and visual semi‐quantification of nigrostriatal functioning predicted phenoconversion. The remaining 268 patients are in follow‐up within the FARPRESTO project. Conclusions: Clinical data (older age, motor and cognitive impairment, constipation, urinary and sexual dysfunction, depression) predicted phenoconversion in this multicenter, longitudinal, observational study. A standardized visual approach for semi‐quantification of DaT‐SPECT is proposed as a practical risk factor for phenoconversion in iRBD patients. Of note, non‐converted and newly diagnosed iRBD patients, who represent a trial‐ready cohort for upcoming disease‐modification trials, are currently being enrolled and followed in the FARPRESTO study. New data are expected to allow better risk characterization. [ABSTRACT FROM AUTHOR]

Published
2023
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33. NPC1 variants are not associated with Parkinson’s disease, REM-sleep behavior disorder or dementia with Lewy bodies in European cohorts

Author

Somerville, Emma N., primary, Krohn, Lynne, additional, Yu, Eric, additional, Rudakou, Uladzislau, additional, Senkevich, Konstantin, additional, Ruskey, Jennifer A., additional, Asayesh, Farnaz, additional, Ahmad, Jamil, additional, Spiegelman, Dan, additional, Dauvilliers, Yves, additional, Arnulf, Isabelle, additional, Hu, Michele T.M., additional, Montplaisir, Jacques Y., additional, Gagnon, Jean-François, additional, Desautels, Alex, additional, Ibrahim, Abubaker, additional, Stefani, Ambra, additional, Högl, Birgit, additional, Gigli, Gian Luigi, additional, Valente, Mariarosaria, additional, Janes, Francesco, additional, Bernardini, Andrea, additional, Dusek, Petr, additional, Sonka, Karel, additional, Kemlink, David, additional, Plazzi, Giuseppe, additional, Antelmi, Elena, additional, Biscarini, Francesco, additional, Mollenhauer, Brit, additional, Trenkwalder, Claudia, additional, Sixel-Doring, Friederike, additional, Figorilli, Michela, additional, Puligheddu, Monica, additional, De Cock, Valerie Cochen, additional, Oertel, Wolfgang, additional, Janzen, Annette, additional, Ferini-Strambi, Luigi, additional, Heibreder, Anna, additional, Monaca, Christelle Charley, additional, Abril, Beatriz, additional, Dijkstra, Femke, additional, Viaene, Mineke, additional, Boeve, Bradley F., additional, Postuma, Ronald B., additional, Rouleau, Guy A., additional, and Gan-Or, Ziv, additional

Published
2023
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36. Progression of clinical markers in prodromal Parkinson's disease and dementia with Lewy bodies: a multicentre study

Author

Joza, Stephen, Hu, Michele T, Jung, Ki-Young, Kunz, Dieter, Stefani, Ambra, Dušek, Petr, Terzaghi, Michele, Arnaldi, Dario, Videnovic, Aleksandar, Schiess, Mya C, Hermann, Wiebke, Lee, Jee-Young, Ferini-Strambi, Luigi, Lewis, Simon J G, Leclair-Visonneau, Laurène, Oertel, Wolfgang H, Antelmi, Elena, Sixel-Döring, Friederike, Cochen De Cock, Valérie, Liguori, Claudio, Liu, Jun, Provini, Federica, Puligheddu, Monica, Nicoletti, Alessandra, Bassetti, Claudio L A, Bušková, Jitka, Dauvilliers, Yves, Ferri, Raffaele, Montplaisir, Jacques Y, Lawton, Michael, Kim, Han-Joon, Bes, Frederik, Högl, Birgit, Šonka, Karel, Fiamingo, Giuseppe, Pietro, Mattioli, Lavadia, Maria Lorena, Suescun, Jessika, Woo, Kyung Ah, Marelli, Sara, Ehgoetz Martens, Kaylena, Janzen, Annette, Plazzi, Giuseppe, Mollenhauer, Brit, Fernandes, Mariana, Li, Yuanyuan, Cortelli, Pietro, Figorilli, Michela, Cicero, Calogero Edoardo, Schaefer, Carolin, Guiraud, Lily, Lanza, Giuseppe, Gagnon, Jean-François, Sunwoo, Jun-Sang, Ibrahim, Abubaker, Girtler, Nicola, Trenkwalder, Claudia, Baldelli, Luca, Pelletier, Amelie, and Postuma, Ronald B

Subjects
REM sleep behavior disorder, evolution, Parkinson’s disease, Neurology (clinical), prodromal stage, 610 Medicine & health, dementia with Lewy bodies
Abstract

The neurodegenerative synucleinopathies, including Parkinson’s disease and dementia with Lewy bodies, are characterized by a typically lengthy prodromal period of progressive subclinical motor and non-motor manifestations. Among these, idiopathic REM sleep behaviour disorder is a powerful early predictor of eventual phenoconversion, and therefore represents a critical opportunity to intervene with neuroprotective therapy. To inform the design of randomized trials, it is essential to study the natural progression of clinical markers during the prodromal stages of disease in order to establish optimal clinical end points. In this study, we combined prospective follow-up data from 28 centres of the International REM Sleep Behavior Disorder Study Group representing 12 countries. Polysomnogram-confirmed REM sleep behaviour disorder subjects were assessed for prodromal Parkinson’s disease using the Movement Disorder Society criteria and underwent periodic structured sleep, motor, cognitive, autonomic and olfactory testing. We used linear mixed-effect modelling to estimate annual rates of clinical marker progression stratified by disease subtype, including prodromal Parkinson’s disease and prodromal dementia with Lewy bodies. In addition, we calculated sample size requirements to demonstrate slowing of progression under different anticipated treatment effects. Overall, 1160 subjects were followed over an average of 3.3 ± 2.2 years. Among clinical variables assessed continuously, motor variables tended to progress faster and required the lowest sample sizes, ranging from 151 to 560 per group (at 50% drug efficacy and 2-year follow-up). By contrast, cognitive, olfactory and autonomic variables showed modest progression with higher variability, resulting in high sample sizes. The most efficient design was a time-to-event analysis using combined milestones of motor and cognitive decline, estimating 117 per group at 50% drug efficacy and 2-year trial duration. Finally, while phenoconverters showed overall greater progression than non-converters in motor, olfactory, cognitive and certain autonomic markers, the only robust difference in progression between Parkinson’s disease and dementia with Lewy bodies phenoconverters was in cognitive testing. This large multicentre study demonstrates the evolution of motor and non-motor manifestations in prodromal synucleinopathy. These findings provide optimized clinical end points and sample size estimates to inform future neuroprotective trials.

Published
2023

37. Neuropsychological and Behavioral Profile in Sleep-Related Hypermotor Epilepsy (SHE) and Disorders of Arousal (DOA): A Multimodal Analysis

Author

Puligheddu, Monica, primary, Congiu, Patrizia, additional, Figorilli, Michela, additional, Tamburrino, Ludovica, additional, Pisanu, Patrizia, additional, Coa, Roberta, additional, Mascia, Maria Giuseppina, additional, Fonti, Davide, additional, Lecca, Rosamaria, additional, Grossi, Enzo, additional, and Gagliano, Antonella, additional

Published
2023
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40. NPC1variants are not associated with Parkinson’s Disease, REM-sleep behaviour disorder or Dementia with Lewy bodies in European cohorts

Author

Somerville, Emma N., primary, Krohn, Lynne, additional, Yu, Eric, additional, Rudakou, Uladzislau, additional, Senkevich, Konstantin, additional, Ruskey, Jennifer A., additional, Asayesh, Farnaz, additional, Ahmad, Jamil, additional, Spiegelman, Dan, additional, Dauvilliers, Yves, additional, Arnulf, Isabelle, additional, Hu, Michele T.M., additional, Montplaisir, Jacques Y., additional, Gagnon, Jean-François, additional, Desautels, Alex, additional, Ibrahim, Abubaker, additional, Stefani, Ambra, additional, Hogl, Birgit, additional, Gigli, Gian Luigi, additional, Valente, Mariarosaria, additional, Janes, Francesco, additional, Bernardini, Andrea, additional, Dusek, Petr, additional, Sonka, Karel, additional, Kemlink, David, additional, Plazzi, Giuseppe, additional, Antelmi, Elena, additional, Biscarini, Francesco, additional, Mollenhauer, Brit, additional, Trenkwalder, Claudia, additional, Sixel-Doring, Friederike, additional, Figorilli, Michela, additional, Puligheddu, Monica, additional, De Cock, Valerie Cochen, additional, Ferini-Strambi, Luigi, additional, Heibreder, Anna, additional, Monaca, Christelle Charley, additional, Abril, Beatriz, additional, Dijkstra, Femke, additional, Viaene, Mineke, additional, Boeve, Bradley F., additional, Postuma, Ronald B., additional, Rouleau, Guy A., additional, and Gan-Or, Ziv, additional

Published
2022
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43. Severity of REM sleep without atonia correlates with measures of cognitive impairment and depressive symptoms in REM sleep behaviour disorder.

Author

Figorilli, Michela, Meloni, Federico, Lecca, Rosamaria, Tamburrino, Ludovica, Mascia, Maria Giuseppina, Cocco, Viola, Meloni, Mario, Marques, Ana Raquel, Vidal, Tiphaine, Congiu, Patrizia, Defazio, Giovanni, Durif, Frank, Lanza, Giuseppe, Ferri, Raffaele, Schenck, Carlos H., Fantini, Maria Livia, and Puligheddu, Monica

Abstract

Summary: This study aimed to correlate REM sleep without atonia (RSWA) and neuropsychological data in patients with idiopathic/isolated REM sleep behaviour disorder (iRBD) and those with RBD associated with Parkinson's disease (PDRBD), in order to assess whether higher degrees of RSWA are related to poorer cognitive performance. A total of 142 subjects were enrolled: 48 with iRBD, 55 with PDRBD, and 39 PD without RBD (PDnoRBD). All participants underwent video‐polysomnographic recording, clinical and neuropsychological assessment. RSWA was quantified according to two manual scoring methods (Montréal, SINBAR) and one automated (REM atonia index, RAI). Mild cognitive impairment (MCI) was diagnosed according to diagnostic criteria for MCI in Parkinson's disease. The relationship between neuropsychological scores and RSWA metrics was explored by multiple linear regression analysis and logistic regression models. Patients with iRBD showed significantly lower visuospatial functions and working memory, compared with the others. More severe RSWA was associated with a higher risk of reduced visuospatial abilities (OR 0.15), working memory (OR 2.48), attention (OR 2.53), and semantic fluency (OR 0.15) in the iRBD. In the whole group, a greater RSWA was associated with an increased risk for depressive symptoms (OR 3.6). A total of 57(40%) MCI subjects were found (17 iRBD, 26 PDRBD, and 14 PDnoRBD). Preserved REM‐atonia was associated with a reduced odds of multi‐domain MCI in the whole study population (OR 0.54). In conclusion, a greater severity of RSWA was associated with an increased risk for poor cognitive performance and depressive mood in patients with RBD. Moreover, higher RAI was associated with a lower risk of multi‐domain MCI. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Reduced Intracortical Facilitation to TMS in Both Isolated REM Sleep Behavior Disorder (RBD) and Early Parkinson’s Disease with RBD

Author

Lanza, Giuseppe, primary, Cosentino, Filomena Irene Ilaria, additional, Lanuzza, Bartolo, additional, Tripodi, Mariangela, additional, Aricò, Debora, additional, Figorilli, Michela, additional, Puligheddu, Monica, additional, Fisicaro, Francesco, additional, Bella, Rita, additional, Ferri, Raffaele, additional, and Pennisi, Manuela, additional

Published
2022
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50. Risk Factors for Phenoconversion in Rapid Eye Movement Sleep Behavior Disorder

Author

Zhang, Hui, primary, Iranzo, Alex, additional, Högl, Birgit, additional, Arnulf, Isabelle, additional, Ferini‐Strambi, Luigi, additional, Manni, Raffaele, additional, Miyamoto, Tomoyuki, additional, Oertel, Wolfgang H., additional, Dauvilliers, Yves, additional, Ju, Yo‐EI, additional, Puligheddu, Monica, additional, Sonka, Karel, additional, Pelletier, Amélie, additional, Montplaisir, Jacques Y., additional, Stefani, Ambra, additional, Ibrahim, Abubaker, additional, Frauscher, Birgit, additional, Leu‐Semenescu, Smaranda, additional, Zucconi, Marco, additional, Terzaghi, Michele, additional, Miyamoto, Masayuki, additional, Janzen, Annette, additional, Figorilli, Michela, additional, Fantini, Maria L., additional, and Postuma, Ronald B., additional

Published
2022
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