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Your search keyword '"Fietkau, Katharina"' showing total 15 results
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15 results on '"Fietkau, Katharina"'

1. Management of patients with seasonal allergic rhinitis: Diagnostic consideration of sensitization to non‐frequent pollen allergens

Author

Höflich, Conny, primary, Balakirski, Galina, additional, Hajdu, Zuzanna, additional, Baron, Jens Malte, additional, Fietkau, Katharina, additional, Merk, Hans F., additional, Strassen, Ulrich, additional, Bier, Henning, additional, Dott, Wolfgang, additional, Mücke, Hans‐Guido, additional, Straff, Wolfgang, additional, Wurpts, Gerda, additional, Yazdi, Amir S., additional, Chaker, Adam, additional, and Röseler, Stefani T. M., additional

Published
2021
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5. “New” inhalant plant allergens

Author

Röseler, Stefani T.M., primary, Baron, Jens M., additional, Höflich, Conny, additional, Merk, Hans F., additional, Bas, Murat, additional, Bier, Henning, additional, Dott, Wolfgang, additional, Fietkau, Katharina, additional, Hajdu, Zuzanna, additional, Kaiser, Lorraine, additional, Kraus, Thomas, additional, Laven, Gottfried, additional, Moll-Slodowy, Silke, additional, Mücke, Hans-Guido, additional, Straff, Wolfgang, additional, Wurpts, Gerda, additional, Yazdi, Amir S., additional, Chaker, Adam, additional, and Balakirski, Galina, additional

Published
2020
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10. Macrophage migration inhibitory factor protects from nonmelanoma epidermal tumors by regulating the number of antigen-presenting cells in skin

Author

Brocks, Tania, Fedorchenko, Oleg, Schliermann, Nicola, Stein, Astrid, Moll, Ute M., Seegobin, Seth, Dewor, Manfred, Hallek, Michael, Marquardt, Yvonne, Fietkau, Katharina, Heise, Ruth, Huth, Sebastian, Pfister, Herbert, Bernhagen, Juergen, Bucala, Richard, Baron, Jens M., Fingerle-Rowson, Guenter, Brocks, Tania, Fedorchenko, Oleg, Schliermann, Nicola, Stein, Astrid, Moll, Ute M., Seegobin, Seth, Dewor, Manfred, Hallek, Michael, Marquardt, Yvonne, Fietkau, Katharina, Heise, Ruth, Huth, Sebastian, Pfister, Herbert, Bernhagen, Juergen, Bucala, Richard, Baron, Jens M., and Fingerle-Rowson, Guenter

Abstract

The response of the skin to harmful environmental agents is shaped decisively by the status of the immune system. Keratinocytes constitutively express and secrete the chemokine-like mediator, macrophage migration inhibitory factor (MIF), more strongly than dermal fibroblasts, thereby creating a MIF gradient in skin. By using global and epidermis-restricted Mif-knockout (Mif(-1-) and K14-Cre(+ltg) ;Mif(fllft)) mice, we found that MIF both recruits and maintains antigen-presenting cells in the dermis/epidermis. The reduced presence of antigen-presenting cells in the absence of MIF was associated with accelerated and increased formation of nonmelanoma skin tumors during chemical carcinogenesis. Our results demonstrate that MIF is essential for maintaining innate immunity in skin. Loss of keratinocyte-derived MIF leads to a loss of control of epithelial skin tumor formation in chemical skin carcinogenesis, which highlights an unexpected tumor-suppressive activity of MIF in murine skin.- Brocks, T., Fedorchenko, O., Schliermann, N., Stein, A., Moll, U. M., Seegobin, S., Dewor, M., Hallek, M., Marquardt, Y., Fietkau, K., Heise, R., Huth, S., Pfister, H., Bernhagen, J., Bucala, R., Baron, J. M., Fingerle-Rowson, G. Macrophage migration inhibitory factor protects from nonmelanoma epidermal tumors by regulating the number of antigen-presenting cells in skin.

Published
2017

12. Macrophage migration inhibitory factor protects from nonmelanoma epidermal tumors by regulating the number of antigen‐presenting cells in skin

Author

Brocks, Tania, primary, Fedorchenko, Oleg, additional, Schliermann, Nicola, additional, Stein, Astrid, additional, Moll, Ute M., additional, Seegobin, Seth, additional, Dewor, Manfred, additional, Hallek, Michael, additional, Marquardt, Yvonne, additional, Fietkau, Katharina, additional, Heise, Ruth, additional, Huth, Sebastian, additional, Pfister, Herbert, additional, Bernhagen, Juergen, additional, Bucala, Richard, additional, Baron,, Jens M., additional, and Fingerle‐Rowson, Guenter, additional

Published
2016
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14. Synthesis of a Sulfonimidamide-Based Analog of Tasisulam and Its Biological Evaluation in the Melanoma Cell Lines SKMel23 and A375.

Author

Steinkamp, anne-Dorothee, Schmitt, Laurenz, Chen, Xiaoyun, Fietkau, Katharina, Heise, Ruth, Baron, Jens M., and Bolm, Carsten

Abstract

Tasisulam is a promising antitumor agent with complex pharmacology, which is used as an antiproliferative agent in patients with metastatic melanoma and other solid tumors. Phase 2 melanoma studies showed promising results but had to be stopped because of insufficient tasisulam clearance leading to toxic side effects. To reduce the negative effects of tasisulam, we synthesized a novel sulfonimidamidebased analog to evaluate its antiproliferative effects in comparison to the original compound by performing a cell proliferation assay in melanoma cell lines SKMel23 and A375. The results revealed that the analog had inhibitory effects on the proliferation comparable to tasisulam in both investigated cell lines. These results could contribute to a reduced toxicity of tasisulam and lead to further clinical trials in metastatic melanoma. [ABSTRACT FROM AUTHOR]

Published
2017
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15. Macrophage migration inhibitory factor protects from nonmelanoma epidermal tumors by regulating the number of antigen-presenting cells in skin.

Author

Brocks T, Fedorchenko O, Schliermann N, Stein A, Moll UM, Seegobin S, Dewor M, Hallek M, Marquardt Y, Fietkau K, Heise R, Huth S, Pfister H, Bernhagen J, Bucala R, Baron JM, and Fingerle-Rowson G

Subjects
Animals, Anthracenes toxicity, Antigens, CD genetics, Antigens, CD metabolism, Carcinogenesis, Gene Expression Regulation physiology, Inflammation metabolism, Keratinocytes metabolism, Macrophage Migration-Inhibitory Factors genetics, Mice, Mice, Inbred BALB C, Mice, Knockout, Mice, Transgenic, Piperidines toxicity, Pyridines toxicity, Receptors, CXCR genetics, Receptors, CXCR metabolism, Macrophage Migration-Inhibitory Factors metabolism, Skin cytology, Skin immunology, Skin Neoplasms chemically induced
Abstract

The response of the skin to harmful environmental agents is shaped decisively by the status of the immune system. Keratinocytes constitutively express and secrete the chemokine-like mediator, macrophage migration inhibitory factor (MIF), more strongly than dermal fibroblasts, thereby creating a MIF gradient in skin. By using global and epidermis-restricted Mif-knockout (Mif -/- and K14-Cre +/tg ; Mif fl/fl ) mice, we found that MIF both recruits and maintains antigen-presenting cells in the dermis/epidermis. The reduced presence of antigen-presenting cells in the absence of MIF was associated with accelerated and increased formation of nonmelanoma skin tumors during chemical carcinogenesis. Our results demonstrate that MIF is essential for maintaining innate immunity in skin. Loss of keratinocyte-derived MIF leads to a loss of control of epithelial skin tumor formation in chemical skin carcinogenesis, which highlights an unexpected tumor-suppressive activity of MIF in murine skin.-Brocks, T., Fedorchenko, O., Schliermann, N., Stein, A., Moll, U. M., Seegobin, S., Dewor, M., Hallek, M., Marquardt, Y., Fietkau, K., Heise, R., Huth, S., Pfister, H., Bernhagen, J., Bucala, R., Baron, J. M., Fingerle-Rowson, G. Macrophage migration inhibitory factor protects from nonmelanoma epidermal tumors by regulating the number of antigen-presenting cells in skin., (© FASEB.)

Published
2017
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