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2. Highlights of the EURICUS-I Data

Author

Moreno, R., van Dort, A., Rowan, K., Apolone, G., Fidler, Václav, Vincent, Jean-Louis, editor, Miranda, Dinis Reis, editor, Ryan, David W., editor, Schaufeli, Wilmar B., editor, and Fidler, Václav, editor

Published
1998
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3. Field Work

Author

Miranda, Dinis Reis, Ryan, David W., Schaufeli, Wilmar B., Fidler, Václav, Vincent, Jean-Louis, editor, Miranda, Dinis Reis, editor, Ryan, David W., editor, Schaufeli, Wilmar B., editor, and Fidler, Václav, editor

Published
1998
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4. Recommendations

Author

Miranda, Dinis Reis, Ryan, David W., Schaufeli, Wilmar B., Fidler, Václav, Vincent, Jean-Louis, editor, Miranda, Dinis Reis, editor, Ryan, David W., editor, Schaufeli, Wilmar B., editor, and Fidler, Václav, editor

Published
1998
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5. Conclusions

Author

Miranda, Dinis Reis, Ryan, David W., Schaufeli, Wilmar B., Fidler, Václav, Vincent, Jean-Louis, editor, Miranda, Dinis Reis, editor, Ryan, David W., editor, Schaufeli, Wilmar B., editor, and Fidler, Václav, editor

Published
1998
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6. Integration of Substudies

Author

Miranda, Dinis Reis, Ryan, David W., Schaufeli, Wilmar B., Fidler, Václav, Vincent, Jean-Louis, editor, Miranda, Dinis Reis, editor, Ryan, David W., editor, Schaufeli, Wilmar B., editor, and Fidler, Václav, editor

Published
1998
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7. Study Design

Author

Miranda, Dinis Reis, Ryan, David W., Schaufeli, Wilmar B., Fidler, Václav, Vincent, Jean-Louis, editor, Miranda, Dinis Reis, editor, Ryan, David W., editor, Schaufeli, Wilmar B., editor, and Fidler, Václav, editor

Published
1998
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8. Study Results

Author

Miranda, Dinis Reis, Ryan, David W., Schaufeli, Wilmar B., Fidler, Václav, Vincent, Jean-Louis, editor, Miranda, Dinis Reis, editor, Ryan, David W., editor, Schaufeli, Wilmar B., editor, and Fidler, Václav, editor

Published
1998
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9. Effects of Long-Chain Polyunsaturated Fatty Acid Supplementation of Infant Formula on Cognition and Behaviour at 9 Years of Age

Author

de Jong, Corina, Kikkert, Hedwig K., and Fidler, Vaclav

Abstract

Aim: Long-chain polyunsaturated fatty acid (LCPUFA) supplementation of infant formula may have a beneficial effect on cognitive development. This study aimed to investigate the effect of LCPUFA formula supplementation primarily on cognition and secondarily on behaviour at age 9 years. Special attention was paid to the potentially modifying effect of maternal smoking during pregnancy. Method: A double-blind, randomized control study was performed in two groups of healthy infants born at term: one group, constituting the control group, received standard formula (n = 169) and another group received standard formula supplemented with LCPUFAs (n = 146). A breastfed group (n = 159) served as an additional reference. At 9 years of age, 72% of the children (control group: n = 123; 71 males, 52 females; LCPUFA group: n = 91; 42 males, 49 females; breastfed group: n = 127, 64 males, 63 females) underwent extensive cognitive and behavioural testing. Results: An interaction between infant nutrition and smoking during pregnancy was found. Among children exposed to smoking during pregnancy, LCPUFA supplementation was associated with higher mean verbal IQ scores (p = 0.007) and learning and memory (p = 0.006). Among children not exposed to smoking during pregnancy, LCPUFA supplementation was associated with lower mean verbal memory scores (p = 0.003). Executive function scores were significantly lower in the LCPUFA-supplemented group than in the control group (p = 0.001). Breastfeeding was associated with better performance on IQ (p = 0.005). Interpretation: No consistent beneficial effect of LCPUFA formula supplementation on cognitive development in term-born infants was found. The study confirmed that breastfeeding is associated with better cognition. (Contains 2 tables and 1 figure.)

Published
2012
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10. Construct Validity of the Infant Motor Profile: Relation with Prenatal, Perinatal, and Neonatal Risk Factors

Author

Heineman, Kirsten R., La Bastide-Van Gemert, Sacha, and Fidler, Vaclav

Abstract

Aim: The Infant Motor Profile (IMP) is a qualitative assessment of motor behaviour of infants aged 3 to 18 months. The aim of this study was to investigate construct validity of the IMP through the relation of IMP scores with prenatal, perinatal, and neonatal variables, including the presence of brain pathology indicated by neonatal ultrasound imaging of the brain. Method: A longitudinal prospective study was performed in a group of 30 term infants (12 females, 18 males; median gestational age 40.1wks, range 37.6-42wks) and 59 preterm infants (25 females, 34 males; median gestational age 29.7wks, range 25-34.7wks). IMP assessments were performed at (corrected) ages of 4, 6, 10, 12, and 18 months. Socio-economic and perinatal data were collected, which, in the case of preterm infants, included information on periventricular leukomalacia and intraventricular hemorrhage based on neonatal cranial ultrasound. Data were analysed by fitting mixed-effects models. Results: Gestational age, socio-economic status, and 5-minute Apgar scores were significant determinants of IMP scores in the total group of infants (p less than 0.001, less than 0.002, and less than 0.042 respectively). In the subgroup of preterm infants, IMP scores were significantly affected by brain lesions on neonatal ultrasound (p less than 0.001) and by socio-economic status (p = 0.001). Interpretation: The findings support the construct validity of the IMP: IMP scores are clearly associated with relevant determinants of neuromotor function.

Published
2010
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13. EURICUS-I: Introduction

Author

Miranda, Dinis Reis, Ryan, David W., Schaufeli, Wilmar B., Fidler, Václav, Vincent, Jean-Louis, editor, Miranda, Dinis Reis, editor, Ryan, David W., editor, Schaufeli, Wilmar B., editor, and Fidler, Václav, editor

Published
1998
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16. Preoperative staging of non-small-cell lung cancer with positron-emission tomography

Author

Pieterman, Remge M., Putten, John W.G. van, Meuzelaar, Jacobus J., Mooyaart, Eduard L., Vaalburg, Willem, Koeter, Gerard H., Fidler, Vaclav, Pruim, Jan, and Groen, Harry J.M.

Subjects
Metastasis -- Diagnosis, PET imaging -- Evaluation, Lung cancer, Non-small cell -- Development and progression
Abstract

Positron-emission tomography (PET) appears to be more effective than CT imaging for detecting non-small-cell lung cancer that has spread to other parts of the body. This was the conclusion of a study of 102 patients with non-small-cell lung cancer. PET imaging was more accurate than CT imaging in detecting metastatic cancer and it detected metastatic cancer in 11 patients whose metastatic cancer had not been detected by other methods. Following PET imaging, 42 patients were diagnosed with more advanced cancer than their doctors had suspected, and 20 were diagnosed with less severe cancer.

Published
2000

25. Addition of PTK787/ZK 222584 can lower the dosage of amsacrine to achieve equal amounts of acute myeloid leukemia cell death

Author

Weidenaar, Alida C., de Jonge, Hendrik J. M., Fidler, Vaclav, ter Elst, Arja, Meeuwsen-de Boer, Tiny, Douwes, Jenny, Bouma-ter Steege, Jessica C. A., Haehlen, Karel, Kamps, Willem A., de Bont, Eveline S. J. M., Hahlen, K., Science in Healthy Ageing & healthcaRE (SHARE), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Stem Cell Aging Leukemia and Lymphoma (SALL), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)

Subjects
vascular endothelial growth factor, RECEPTOR, BONE-MARROW, NF-KAPPA-B, SIGNAL-TRANSDUCTION, PTK787/ZK 222584, acute myeloid leukemia, VEGF, C-KIT, amsacrine, AML, hemic and lymphatic diseases, ENDOTHELIAL GROWTH-FACTOR, SURVIVAL, TYROSINE KINASE INHIBITOR
Abstract

Acute myeloid leukemia (AML) is a disease with a poor prognosis. It has been demonstrated that AML cells express the vascular endothelial growth factors, VEGFA and VEGFC, as well as kinase insert domain-containing receptor (VEGFR2), the main receptor for downstream effects, resulting in an autocrine pathway for cell survival. This study investigates the role of the VEGFR inhibitor PTK787/ZK 222584 in leukemic cell death, and the possibility of an additional effect on cell death by a chemotherapeutic drug, amsacrine. In three AML cell lines and 33 pediatric AML patient samples, we performed total cell-kill assays to determine the percentages of cell death achieved by PTK787/ZK 222584 and/or amsacrine. Both drugs induced AML cell death. Using a response surface analysis, we could show that, in cell lines as well as in primary AML blasts, an equal magnitude of leukemic cell death could be obtained when lower doses of the more toxic amsacrine were combined with low dosages of the less toxic VEGFR inhibitor. This study shows that PTK787/ ZK 222584 might have more clinical potential in AML when combined with a chemotherapeutic drug such as amsacrine. In future, it will be interesting to study whether the complications and the long-term effects of chemotherapy can be reduced by lowering the dosages of amsacrine, and by replacing it with other drugs with lower toxicity profiles, such as PTK787/ZK 222584.

Published
2008

30. Reduced Ischemia-Reoxygenation Injury in Rat Intestine After Luminal Preservation With a Tailored Solution

Author

Roskott, Anne Margot, primary, Nieuwenhuijs, Vincent B., additional, Leuvenink, Henri G. D., additional, Dijkstra, Gerard, additional, Ottens, Petra, additional, de Jager, Marina H., additional, Gonalves Dias Pereira, Patricia, additional, Fidler, Vaclav, additional, Groothuis, Geny M. M., additional, Ploeg, Rutger J., additional, and de Graaf, Inge A. M., additional

Published
2010
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33. Mechanism of Biliary Lipid Secretion in the Rat: A Role for Bile Acid-independent Bile Flow?

Author

Verkade, HJ, Wolters, H, Gerding, A, Havinga, R, Fidler, Vaclav, Vonk, RJ, and Kuipers, F

Subjects
EXCRETION, BILIRUBIN, CHOLESTEROL, ORGANIC-ANIONS, CHROMATOGRAPHY, HAMSTER, digestive system, TRANSPORT, GUINEA-PIG
Abstract

Bile acid-induced lipid secretion was compared in unanesthetized normal control and Groningen Yellow Wistar rats during variations in endogenous bile acid output. Groningen Yellow rats express a genetic defect in the biliary secretion of various organic anions. During a 5-hr period after interruption of the enterohepatic circulation, bile acid secretion decreased from 36.4 +/- 1.8 to 1.9 +/- 0.3 mumol per 30 min in normal control rats and from 37.1 +/- 2.8 to 1.8 +/- 0.2 mumol per 30 min in Groningen Yellow rats, respectively (mean +/- S.E.M., n = 5). The relationship between bile acid secretion and bile flow showed similar slopes (normal control, 8.74 +/- 0.44 mul/mumol and Groningen Yellow rats, 7.71 +/- 0.42 mul/mumol) but different y-intercepts (normal control, 243 +/- 8 and Groningen Yellow, 127 +/- 4 mul per 30 min; p

Published
1993

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