1. Decrease of PCDD/F Levels in Human Blood—Trend Analysis for the German Population, 1991–1996
- Author
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Petra Schrey, Jürgen Wittsiepe, U. Ewers, Fidelis Selenka, and Michael Wilhelm
- Subjects
Adult ,Polychlorinated Dibenzodioxins ,Adolescent ,Positive correlation ,Biochemistry ,Animal science ,German population ,Germany ,Humans ,Soil Pollutants ,Child ,Aged ,Benzofurans ,General Environmental Science ,Whole blood ,Aged, 80 and over ,biology ,Human blood ,Chemistry ,Dibenzofurans, Polychlorinated ,Middle Aged ,biology.organism_classification ,Multiplicative model ,Environmental chemistry ,Tasa ,Toxicity ,Regression Analysis ,Polychlorinated dibenzofurans ,Environmental Monitoring - Abstract
More than 500 whole blood samples of normal subjects from Germany collected in 1991–1996 have been analyzed for polychlorinated dibenzo-p-dioxins (PCDD) and dibenzofurans (PCDF) by capillary gas chromatography/high-resolution mass spectrometry. Over the examined time period a continuous decrease of the PCDD/F concentrations in human blood was observed. The mean levels found were about 42.7 pg I-TEq/g (lipid basis) in 1991 and 20.7 pg I-TEq/g (liquid basis) in 1996 {median: 40.8 and 19.2}. A reduction to about half was found for most congeners. Each 1-year subset of the entire collective shows a positive correlation of the PCDD/F blood levels with age for most of the congeners, the sum values, and the calculated toxicity equivalents. For statistical evaluation a multiplicative model was used: Concentration in blood=A.ageB. The correlation is mostly pronounced for lower chlorinated PCDD and for 2,3,4,7,8-PentaCDF.
- Published
- 2000