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2. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain: Abstracts of Symposia and free communications
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Harms, L., Bock, A., JÄnisch, W., Valdueza, J., Weber, J., Link, I., De Keyser, J., Goossens, A., Wilczak, N., Vedeler, C., Bjorge, L., Uvestad, E., Conti, G., Williams, K., Ginsberg, L., Rafique, S., Rapoport, S. I., Gershfeld, N. L., De La Meilleure, G., Crevits, L., Faiss, J. H., Heye, N., Blanke, J., Sackmann, A., Kastrup, O., Doornbos, R., van der Worp, H. B., Kappelle, L. J., Bar, P. R., Davie, C. A., Barker, G. J., Brenton, D., Miller, D. H., Thompson, A. J., Block, F., Schwarz, M., Delodovici, L., Baruzzi, F., Bonaldi, G., Dario, A., Marra, A., Mercuri, A., Dworzak, F., Cavallari, P., Confalonieri, P., Zuffi, M., Antozzi, C., Cornelio, F., Baldissera, F., Chassande, B., Ameri, A., Eymard, B., Poisson, M., Vérier, A., Brunet, P., Congia, S., Murgia, P. L., Cannas, A., Borghero, G., Uselli, S., Mellino, G., Ferrai, R., Lampis, R., Massa, R., Muzzetto, B., Giannini, F., Rossi, S., Cioni, R., d'Aniello, C., Guarneri, A., Battistini, N., Ceriani, F., Del Santo, A., Poloni, M., Campo, J. F., Iglesias, F., Guitera, M. V., Farinas, C., Pascual, J., Leno, C., Berciano, J., Thorpe, I. W., Kendall, B. E., McDonald, W. I., Moulignier, A., Dromer, F., Baudrimont, M., Dupont, B., Gozlan, J., El Amrani, M., Petit, J. C., Roullet, E., Sterzi, R., Causaran, R., Protti, A., Riva, M., Erminio, F., Arena, O., Villa, F., Maccagnano, E., Miletta, M., Spinelli, F., Ben-Hur, T., Weidenfeldl, J., Rao, N. S., Chari, C. C., Laforet, P., Matheron, S., Adams, D., Chemouilli, Ph., Desi, M., Said, G., Davous, P., Lionnet, F., Pulik, M., Genet, P., Rozenberg, F., Cartier, L. M., Castillo, J. L., Cea, J. G., Villagra, R., de Saint Martin, L., Mahieux, F., Manifacier, M. J., Mattos, K., Queiros, C., Publio, L., Vinhas, V., PeÇanha-Martins, A. C., Melo, A., Liska, U., Zifko, U., Budka, H., Drlicek, M., Grisold, W., Kaufmann, R., Kaiser, R., Czygan, M., Gomes, I., Jones, N., Cunha, S., EmbiruÇu, E. Katiane, Vieira, V., Araujo, I., Alexandra, M., Ferreira, A., Goes, J., Chemouilli, P., Israel-Biet, Masson, H., Lacroix, C., Gasnault, J., Hildebrandt-Müller, B., Oschmann, P., Krack, P., Willems, W. R., Dorndorf, W., Freitas, V., Bittencourt, A., Fernandes, D., Nascimento, M. H., Severo, M., Moraes, D., Muller, M., Hasert, K., Merkelbach, S., Schimrigk, K., van Oosten, B. W., Lai, M., Polman, C. H., Bertelsmann, F. W., Hodgkinson, S., Cabre, P. H., Volpe, L., Smadja, D., Vernant, J. P., Villaroya, H., Violleau, K., Younes-Chennoufi, A. Ben, Baumann, N., Villanueva-Hemandez, P., Ballabriga, J., Basart, E., Arbizu, T. X., Perez-Serra, J., Vinuels, F., Giron, J. M., Castilla, J. M., Redondo, L., Izquierdo, G., Lauer, K., Henneberg, A., Bittmann, N., Link, D., Wollinsky, K. H., Mobner, R., Fassbender, K., Kuhnen, J., Schwartz, A., Hennerici, M., Miller, A., Lider, O., Abramsky, O., Weiner, H. L., Offner, H., Vanderbark, A. A., Paoino, E., Fainardi, E., Addonizio, M. C., Ruppi, P., Tola, M. R., Granieri, E., Carreras, M., Sazdovitch, V., Joutel, A., Verdier-taillefer, M. H., Heinzlef, O., Radder, C., Tournier-Lasserve, E., Brenner, R. E., Munro, P. M. G., Williams, S. C. R., Bell, J. D., Hawkins, C. P., Filippi, M., Campi, A., Dousset, V., Canal, N., Comi, G., Zhu, J., Weber, F., Retska, R., List, J., Zhang, L., Brock, M., Taphoorn, M. J. B., Heimans, J. J., van der Veen, E. A., Karim, A. B. M. F., Sarazin, M., Argentino, N., Delattre, J. Y., Derkinderen, P., Buchwald, B., Schroter, G., Serve, G., Franke, C. H., Conrad, B., Kitchen, N. D., Thomas, D. G. T., Forman, A. D., Ang, Kie- Kian, Price, R., Stephens, C., Salmaggi, A., Nermni, R., Silvani, A., Forno, M. G., Luksch, R., Boiardi, A., Grzelec, H., Fryze, C., Nowacki, P., Zdziarska, B., Sanson, M., Merel, P., Richard, S., Rouleau, G., Thomas, G., Olsen, N. K., Pfeiffer, P., Egund, N., Bentzen, S. M., Johannesen, L., Mondrup, K., Rose, C., Zyluk, B., Wondrusch, E., Berger, O., Fast, N., Jellinger, K., Lindner, K., Urman, A., Thibault, J. L., Duyckaerts, Ch., Strik, H., Muller, B., Richter, E., Krauseneck, P., Steinbrecher, A., Schabet, M., Hess, C., Bamberg, M., Dichgans, J., Counsell, C. E., McLeod, M., Grant, R., Creel, G. B., Claus, D., Sieber, E., Engelhardt, A., Rechlin, T., Thierauf, P., Neubauer, U., Peresson, M., Di Giovacchino, G., Romani, G. L., Di Silverio, F., Danek, A., Kuffner, M., Hoermann, R., Schopohl, J., Laska, M., Heye, B., Zangaladze, A. T., Valls-SoIè, J., Cammarota, A., Alvarez, R., Tolosa, E., Hallett, M., Ulbricht, D., Ganslandt, O., Kober, H., Vieth, J., Grummich, P., Pongratz, H., Brigel, C., Fahlbusch, R., Serra, F. P., Palma, V., Nolfe, G., Buscaino, G. A., Rothstein, T. L., Gibson J. M., Morrison P. M., Collins A. D., Eiselt, M., Wagnur, H., Zwiener, U., Schindler, T., Efendi, H., Ertekin, C., Erfas, M., Larsson, L. E., Sirin, H., AraÇ, N., Toygar, A., Demir, Y., Seddigh, S., Vogt, T. H., Hundemer, H., Visbeck, A., Pastena, L., Faralli, F., Mainardi, G., Gagliardi, R., Linden, D., Berlit, P., Lopez, O. L., Becker, J. T., Jungreis, C., Brenner, R., Rezek, D., Dekesky, S. T., Estol, C., Boller, F., Fernandez, J. M., Mederer, S., Batlle, J., Turon, A., Codina, A., Hitzenberger, P., Vila, N., Valls-SolÇ, J., Chamorro, A., Pouget, J., Schmied, A., Morin, D., Azulay, J. Ph., Vedel, J. P., Montalt, J., Escudero, J., Barona, R., Campos, A., Varli, K., Ertem, E., Uludag, B., Yagiz, A., Privorkin, Z., Steinvil, Y., Kott, E., Combarros, O., Sanchez-Pernaute, R., Orizaola, P., Mokrusch, Th., Kutluaye, E., Selcuki, D., Ertikin, C., Zettl, U., Gold, R., Harvey, G. K., Hartung, H. P., Toyka, K. V., Wokke, J. H. J., Oey, P. L., Ippel, P. F., Jansen, G. H., Franssen, H., Toyooka, K., Fujimura, H., Ueno, S., Yoshikawa, H., Yorifuji, S., Yanagihara, T., Talamon, C., Tzourio, C., Kiefer, R., Jung, S., Toyka, K., Ruolt, I., Tranchant, C., Mohr, M., Warter, J. M., Younger, D. S., Rosoklija, G., Hays, A. P., Kurita, R., Hasegawa, O., Matsumto, M., Komiyama, A., Nara, Y., Oueslati, S., Belal, S., Turki, I., Ben Hamida, C., Hentati, F., Ben Hamida, M., Kwiecinski, H., Krolicki, L., Domzal-Stryga, A., Dellemijn, P. L. I., van Deventer, P., van Moll, B., Drogendijk, T., Vecht, Ch. J., Nemni S., Amadio, Fazio, R., Galardin, G., Delodovici, M. L., Peghi, E., Monticelli, M. L., Sessa, A., Viguera, M. L., Palomar, M., Gamez, J., Cervera, C., Navarro, C., Serena, J., Duran, I., Fernandez, A. L., Comabella, M., Nos, C., Rio, J., Montalban, J., Navarro, X., Verdu, E., Darbra, S., Buti, M., Mrabet, A., Fredj, M., Gouider, R., Tounsi, H., Khalfallah, N., Haddad, A., Dbaiss, T., Ghnassia, R., Rouillet, E., Chedru, F., Porsche, H., Strenge, H., Li, S. W., Young, Y. P., Garcia, A. A., Baron, P., Scarpini, E., Bianchi, R., Conti, A., Livraghi, S., Rees, J. H., Gregson, N. A., Hughes, R. A. C., Sedano, M. J., Calleja, J., Canga, E., Bahou, Y., Biary, N., Al Deeb, S. M., Guern, E. L. E., Gugenheim, M., Tardieu, S., Aisonobe, T. M., Agid, Y., Bouche, P., Brice, A., Rautenstrauss, B., Nelis, E., Grehl, H., Van Broeckhoven, C., Pfeiffer, R. A., Liehr, T., Ganzmann, E., Gehring, C., Neundörfer, B., Geremia, L., Doronzo, R., Sacilotto, G., Sergi, P., Pastorino, G. C., Scarlato, G., Planté-Bordeneuve, V., Mantel, A., Baas, F., Moser, H., Antonini, A., Psylla, M., Günther, I., Vontobell, P., Beer, H. F., Leenders, K. L., Chaudhuri, K. Ray, Parker, J., Pye, I. F., Millac, P. A. H., Abbott, R. J., Sutter, M., Albani, C., de Rijk, M. C., Breteler, M. M. B., Graveland, G. A., van der Mechè, F. G. A., Hofman, A., Keipes, M., Hilger, Ch., Diederich, N., Metz, H., Hentges, F., Pollak, P., Benabid, A. L., Limousin, P., Hoffmann, D., Benazzouz, A., Perret, J., Laihinen, A., Rinne, J. O., Ruottinen, H., Nagren, K., Lehikoinen, P., Oikonen, V., Ruotsalainen, U., Rinne, U. K., Cocozza, S., Pizzuti, A., Cavalcanti, F., Monticelli, A., Pianese, L., Redolfi, E., Paiau, F., Di Donato, S., Pandolfo, M., Palau, F., Monros, E., De Michele, G., Smeyers, P., Lopez-ArLandis, J., Uilchez, J., Filla, A., Genis, D., Matilla, T., Volpini, V., Blanchs, M. I., Davalos, A., Molins, A., Rosell, J., Estivill, X., De Jonghe, P., Smeyers, G., Krols, L., Mercelis, R., Hazan, J., Weissenbach, J., Martin, J. J., Warner, T. A. T., Williams, L., Orb, A. S., Harding, A. E., Giunti, P., Sweeney, M. G., Spadaro, M., Jodice, C., Novelletto, A., Malaspina, P., Frontali, M., Salmon, E., Gregoire, Del Fiore, Comar, Franck, G., Scheltens, P. H., Siegfried, K., Dartigues, E., De Deyn, P., Horn, R., Nelson, I., Hanna, M. G., Morgan-Hughes, J. A., Collinge, J., Palmer, M. S., Campbell, T., Mahal, S., Sidle, K., Humphreys, C., Tavitian, B., Pappata, S., Jobert, A., Crouzel, A. M., DiGiamberardino, L., Steimetz, G., Barbanti, P., Fabbrini, G., Salvatore, M., Buzzi, M. G., Di Piero, V., Petraroli, R., Sbriccoli, A., Pocchiari, M., Macchi, G., Lenzi, G. L., Spiegel, R., Maguire, P., Schmid, W., Ott, A., Bots, M. L., Grobbe, D. E., Hofman, A., Howard, R. S., Russell, S., Losseff, N., Hirsch, N. P., Couderc, R., Bailleul, S., Nargeot, M. C., Touchon, J., Picot, M. C., Rizzo, M., Watson, G., McGehee, D., Dingus, T., Kappos, L., Radü, E. W., Haas, J., Hartard, C. H., Spuler, S., Yousry, T., Voltz, R., Scheller, A., Holler, E., Hohlfeld, R., Scolding, N. J., Sussman, J., Kolar, O. J., Farlow, M. R., Rice, P. H., Zipp, F., Sotgiu, S., Weiss, E. H., Wekerle, H., Chalmers, R., Robertson, N., Compston, D. A. S., Martino, G., Clementi, E., Brambilla, E., Moiola, L., Martinelli, V., Colombo, B., Poggi, A., Rovaris, M., Grimaldi, L. M. E., Roth, M. P., Descoins, P., Ballivet, S., Ruidavets, J. B., Waubant, E., Nogueira, L., Cambon-Thomsen, A., Clanet, M., Leppert, D., Hauser, S., Lugaresi, A., Tartaro, A., D'aurelio, P., Befalo, L. L. O., Thomas, A., Malatesta, G., Gambi, D., Benedikz, J. E. G., Magnusson, H., Poser, C. M., Guomundsson, G., Bates, T. E., Davies, S. E. C., Clark, J. B., Landon, D. N., ùther, J. R., Rautenberg, W., Overgaard, K., Sereghy, T., Pedersen, H., Boysen, G., Diez-Tejedor, E., Carceller, F., Gutierrez, M., Lopez-Pajares, R., Roda, J. M., Chandra, B., Ricart, W., Gonzalez-Huix, F., Molina, A., Rundek, T., Demarin, V., De Reuck, J., Boon, P., Decoq, D., Strijckmans, K., Goethals, P., Lemahieu, I., Nibbio, A., Chabriat, H., Vahedi, K., Nagy, T., Verin, M., Mas, J. L., Julien, J., Ducrocq, X., Iba-Zizen, M. T., Cabanis, E. A., Bousser, M. G., Rolland, Y., Landgraf, F., Bompais, B., Lemaitre, M. H., Edan, G., Vorstrup, S., Knudsen, L., Olsen, K. Skovgaard, Videbaek, C., Schroeder, T., van Gijn, J., Jansen, H. M. L., Pruim, J., Paans, A. M. J., Willemsen, A. T. M., Hew, J. M., vd Vliet, A. M., Haaxma, R., Vaalburg, W., Minderhoud, J. M., Korf, J., Soudain, S. E., Ho, T. W., Mishu, B., Li, C. Y., Nachainkin, I., Gao, C. Y., Cornblath, D. R., Griffin, J. W., Asbury, A. K., Blaser, M. J., McKhann, G. M., Ho, T., Macko, C., Xue, P., Stadlan, E. M., Ramos-Alvarez, M., Valenciano, L., Visser, L. H., van der Meché, F. G. A., van Darn, P. A., Meulstee, J., Schmitz, P. I. M., Jacobs, B., Oomes, P. G., Kleyweg, R. P., Jacobs, B. C., Endtz, H. P., van Doorn, P. A., van der Mech, F. G. A., Van den Berg, L. H., Mollee, I., Logtenberg, T., Thomas, P. K., Plant, G., Baxter, P. J., Luis, R. Santiago, Matsumoto, M., Notermans, N. C., Wokke, J. H. J., Lokhorst, H. M., van der Graaf, Y., Jennekens, F. G. I., Azulay, J. P., Bille-Turg, F., Valentin, P., Farnarier, G. G., Pellissier, J. F., Serratrice, G., Quasthoff, S., Schneider, U., Grafe, P., Hilkens, P. H. E., Moll, J. W. B., van der Burg, M. E. L., Planting, A. S. T., van Putten, W. L. J., van den Bent, M. J., Birklein, F., Spitzer, A., Lang, E., Neundorfer, B., Diehl, R. R., Lücke, D., Smith, G. D. P., Mathias, C. J., Serra, J., Campera, M., Ochoa, J. L., Ray Chaudhuri, K., Pavitt, D., Alam, M., Handwerker, H. O., Bleasdale-Barr, K., Smith, G., Murray, N. M. F., Hawkins, P., Pepys, M., Gellera, C., DiDonato, S., Taroni, F., Uncini, A., Di Muzio, A., Servidei, S., Silvestri, G., Lodi, R., Iotti, S., Barbiroli, B., Morrissey, S. P., Borruat, F. X., Francis, D., Mosely, I., Hansen, H. C., Helmke, K., Kunze, K., Sadzot, B., Maquet, P., Lemaire, Plenevaux, Damhaut, Sommer, C., Myers, R. R., Berta, E., Mantegazza, R., Argov, Z., Shapira, Y., Wirguin, I., Beuuer, J., Franke, C., Roberts, M., Willison, H., Vincent, A., Newsom-Davis, J., Morrison, K. E., Damels, R., Francis, M., Campbell, L., Davies, K. E., Kohler, W., Bucka, C., Hertel, G., Kanovsky, P., Auer, D., Ackermann, H., Klose, U., Naegele, Th., Bien, S., Voigt, K., Fink, G. R., Stephan, K. M., Wise, R. J. S., Mullatti, N., Hewer, L., Frackowiak, R. S. J., Weiller, C. S., Rijnites, M., Jueptner, M., Bauermann, T., Krams, M., Diener, H. C., van Walderveen, M. A. A., Barkhof, F., Hommes, O. R., Valk, J., Willmer, J. P., Guzman, D. A., Passingham, R. E., Silbersweig, D., Ceballos-Baumann, A., Frith, C. D., Frackowiak, R., Lucas, C. H., Goullard, L., Marchau, M. J., Godefroy, O., Rondepierre, P. H., Chamas, E., Mounier-Vehier, F., Leys, D., Renato, J., Verdugo, M. S. C., Campero, M., Jose, L., Ochoa, D. S. C., Vivancos, F., Tejedor, E. Diez, Martinez, N., Roda, J., Frank, A., Barreiro, P., Satoh, Y., Nagata, K., Maeda, T., Hirata, Y., YalÇinerner, B., Ozkara, C., Ozer, F., Ozer, S., Hanoglu, L., Zunker, P., Pozo, J. L., Oberwittler, C., Schick, A., Buschmann, H. -Ch., Ringelstein, E. Bernd, Lara, M., Anzola, G. P., Magoni, M., Volta, G. Dalla, Tarasov, A., Feigin, V., Beaudry, M. G., Carrier, S., Chicoutimi, Henriques, I. L., Bogoussslavsky, J., van Melle, G., Mathieu, J., Perusse, L., Allard, P., Prevost, C., Cantin, L., Bouchard, J. M., De Braekeleer, M., Agbo, C., Neau, J. P., Tantot, A. M., Dary-Auriol, M., Ingrand, P., Gil, R., Baltadjiev, D., Zekin, D., Sabey, K., Gennaula, C. P., Pope, B. A., Caparros-Lefebvre, D., Girard-Buttaz, I., Pruvo, J. P., Petit, H., Hipola, D., Martin, M., Giménez-Roldan, S., Ivanez, V., Japaridze, G., Carrasco, J. L., Picomell, I., Herranz, J. L., Macias, J. A., Nieto, M., Noya, M., Oller, L., Kiteva-Trencevska, G., Delgado, M. R., Liu, H., Luengo, A., Parra, J., Colas, J., Fernandez, M. J., Manzanares, R., Kornhuber, M. E., Malashkhia, V., Orkodashili, G., Martinez, M., Bonaventura, I., Porta, G., Martinez, I., Fernandez, A., Aguilar, M., Masnou, P., Drouet, A., Dreyfus, M., Cartron, J., Morel-Kopp, M. C., Tchernia, G., Kaplan, C., Lammers, M. W., Hekster, Y. A., Keyser, A., Meinardi, H., Renier, W. O., Boon, P. A. J. M., Have, M. D., Kint, B., Cruz, P., Cadilha, A., Almeida, R., Goncalves, M., Pimenta, M., Ramos, L. M. P., Polder, T. W., Broere, C. A., Polman, L., Rother, I., Rother, M., Schlaug, G., Arnold, S., Holthausen, H., Wunderlich, G., Ebner, A., Luders, H., Witte, O. W., Seitz, R. J., Serra, L. L., Gallicchio, B., Rotondi, F., Wieshmann, U., Meierkord, H., Sabev, K., Di Carlo, V., Gueguen, B., Derouesné, Ch., Ancri, D., Bourdel, M. C., Guillou, S., Aliaga, R., Chornet, M. A., Rodrigo, A., Pascual, A. Pascual -Leone, Catala, M. D., Pascual-Leone, A., Benbadis, S. R., Dinner, D. S., Chelune, G. J., Lüders, H. O., Piedmonte, M. R., Blanco, T., Lopez, M. P., Romero, B., Deltoro, A., Pascual, A., Pascual, Leone, Bolgert, F., Josse, M. O., Tassan, P., Touze, E., Laplane, D., Godenberg, F., Brizioli, E., Del Gobbo, M., Pelliccioni, G., Scarpino, O., Durak, H., Damlacik, G., Tunca, Z., Fidaner, H., Yurekli, Y., Yemez, B., Kaygisiz, A., Anllo, E. A., Esperet, E., Giovagnoli, A. R., Casazza, M., Spreafico, R., Avanzini, G., Mascheroni, S., Vecchio, I., Tornali, C., Antonuzzo, A., Grasso, A. A., Bella, R., Pennisi, G., Raffaele, R., Broeckx, J., Schildermans, F., Hospers, W., Deberdt, W., Carney, J. M., Aksenova, M., Chen, M. S., Juncadella, M., Busquets, N., De la Fuente, I., Rodriguez, A., Rubio, F., Soler, R., Khati, C., Pillon, B., Deweer, B., Malapani, C., Malichard, N., Dubois, B., Rancurel, G., Lopez, D. L., Jungreia, G., DeKosky, S. T., Boiler, F., Weiller, C., Rijntjes, M., Mueller, S. P., Maguire, E. A., Burke, E. T., Staunton, H., Phillips, J., Rousseaux, M., Pena, J., Bertran, I., Santacruz, P., Lopez, R., Catafau, A., Lomena, F., Blesa, R., Rampello, L., Nicoletti, A., Cabaret, M., Lesoin, F., Steinling, M., Tournev, I., Maier-Hauff, K., Schroeder, M., Wolf, A., Cochin, J. P., Noel, I., Augustin, P., Auzou, P., Hannequin, D., Maria, V., Lopez-Bresnahan, Danielle, D. M., Antin-Ozerkis B. A., Bartels, E., Rodiek, S. O., Flugel, K. A., Campos, D. M., Salas-Puig, J., Del Rio, J. Sanhez, Vidal, J. A., Lahoz, C. H., Eraksoy, M., Barlas, O., Barlas, M., Bayindir, C., Ozcan, H., Birbamer, G., Gerstenbrand, F., Felber, S., Luz, G., Aichner, F., Seidel, G., Kaps, M., Hutzelmann, A., Gerriets, T., Kruggel, F., Martin, P. J., Gaunt, M. E., Abbot, R. J., Naylor, A. R., Meary, E., Dilouya, A., Meder, J. F., De Recondo, J., Lebtahi, R., Neff, K. W., Meairs, S., Viola, S., Matta, E., Aquilone, L., Rise, I. R., Authier, F. J., Kondo, H., Ghnassia, R. T., Degos, J. D., Gherardi, R. K., Bardoni A., Ciafaloni E., Comi G. P., Bresolin N., Robotti M., Moggio M., Rigoletto C., Roses A., Scarlato G., Castelli, E., Turconi, A., Bresolin, N., Perani, D., Felisari, G., Chariot, P., de Pinieux, G., Astier, A., Jacotot, B., Gherardi, R., Fischer-Gagnepain, V., Louboutin, J. P., Crespo, F., Florea-Strat, A., Fromont, G., Sabourin, J. -C., Gonano, E. -F., Moroni, I., Prelle, A., Iannaccone, S., Quattrini, A., deRino, F., Sessa, M., Golzi, V., Smirne, S., Nemni, R., Turpin, J. C., Lucotte, G., Jacobs, S. C. J. M., Willems, P. W. A., Bootsma, A. L., Lasa, A., Calaf, M., Baiget, M., Gallano, B., Fichter-Gagnepain, V., Mazzucchelli, F., D'Angelo, M. G., Velicogna, M., Bet, L., Comi, G. P., Bordoni, A., Gonano, E. F., Bazzi, P., Rapuzzi, S., Moggio, M., Fagiolari, G., Ciscato, P., Messina, A., Battistel, A., Ryniewicz, B., Sangla, I., Desnuelle, C., Paquis, V., Cozzone, P. J., Bendahan, D., Sturenburg, H. 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M., Pleiffer, G., Kunre, K., Dieterich, M., Brandt, Th., Guarino, M., Stracciari, A., Pazzaglia, P., D'Alessandro, R., Santilli, I., Donato, M., The European Velnacrine Study Group, The Dutch Guillain-Barré study group, The COP-1 Multicenter Clinical and Research Group Study, and European Study Group
- Published
- 1994
- Full Text
- View/download PDF
3. Consolidation Radiotherapy Could Be Safely Omitted in Advanced Hodgkin Lymphoma With Large Nodal Mass in Complete Metabolic Response After ABVD: Final Analysis of the Randomized GITIL/FIL HD0607 Trial
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Gallamini, A, Rossi, A, Patti, C, Picardi, M, Romano, A, Cantonetti, M, Oppi, S, Viviani, S, Bolis, S, Trentin, L, Gini, G, Battistini, R, Chauvie, S, Sorasio, R, Pavoni, C, Zanotti, R, Cimminiello, M, Schiavotto, C, Viero, P, Mulé, A, Fallanca, F, Ficola, U, Tarella, C, Guerra, L, Rambaldi, A, Gallamini, Andrea, Rossi, Andrea, Patti, Caterina, Picardi, Marco, Romano, Alessandra, Cantonetti, Maria, Oppi, Sara, Viviani, Simonetta, Bolis, Silvia, Trentin, Livio, Gini, Guido, Battistini, Roberta, Chauvie, Stephane, Sorasio, Roberto, Pavoni, Chiara, Zanotti, Roberta, Cimminiello, Michele, Schiavotto, Corrado, Viero, Piera, Mulé, Antonino, Fallanca, Federico, Ficola, Umberto, Tarella, Corrado, Guerra, Luca, Rambaldi, Alessandro, Gallamini, A, Rossi, A, Patti, C, Picardi, M, Romano, A, Cantonetti, M, Oppi, S, Viviani, S, Bolis, S, Trentin, L, Gini, G, Battistini, R, Chauvie, S, Sorasio, R, Pavoni, C, Zanotti, R, Cimminiello, M, Schiavotto, C, Viero, P, Mulé, A, Fallanca, F, Ficola, U, Tarella, C, Guerra, L, Rambaldi, A, Gallamini, Andrea, Rossi, Andrea, Patti, Caterina, Picardi, Marco, Romano, Alessandra, Cantonetti, Maria, Oppi, Sara, Viviani, Simonetta, Bolis, Silvia, Trentin, Livio, Gini, Guido, Battistini, Roberta, Chauvie, Stephane, Sorasio, Roberto, Pavoni, Chiara, Zanotti, Roberta, Cimminiello, Michele, Schiavotto, Corrado, Viero, Piera, Mulé, Antonino, Fallanca, Federico, Ficola, Umberto, Tarella, Corrado, Guerra, Luca, and Rambaldi, Alessandro
- Abstract
PURPOSE To investigate the role of consolidation radiotherapy (cRT) in advanced-stage Hodgkin lymphoma (HL) presenting at baseline with a large nodal mass (LNM) in complete metabolic response after doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy. PATIENTS AND METHODS Advanced-stage (IIB-IVB) HL patients, enrolled in the HD 0607 trial (Clinicaltrial.gov identifier NCT00795613), with both a negative PET after two (PET-2) and six (PET-6) ABVD cycles, who presented at baseline with an LNM, defined as a nodal mass with the largest diameter $ 5 cm, were prospectively randomly assigned to receive cRT over the LNM or no further treatment (NFT). RESULTS Among 296 randomly assigned patients, the largest diameter of LNM at baseline was 5-7 cm in 101 (34%; subgroup A) and 8-10 cm in 96 (32%; subgroup B), whereas classic bulky (diameter. 10 cm) was detected in 99 (33%; subgroup C). Two hundred eighty patients (88%) showed a postchemotherapy RM. The median dose of cRT was 30.6 Gy (range, 24-36 Gy). After a median follow-up of 5.9 years (range, 0.5-10 years), the 6-year progression-free survival rate of patients who underwent cRT or NFT was, respectively, 91% (95% CI, 84% to 99%) and 95% (95% CI, 89% to 100%; P 5.62) in subgroup A; 98% (95% CI, 93% to 100%) and 90% (95% CI, 80% to 100%; P 5.24) in subgroup B; 89% (95% CI, 81% to 98%) and 86% (95% CI, 77% to 96%; P 5.53) in subgroup C (classic bulky). CONCLUSION cRT could be safely omitted in patients with HL presenting with an LNM and a negative PET-2 and PET-6 scan, irrespective from the LNM size detected at baseline.
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- 2020
4. Difficoltà di identificazione della sindrome MEN2B ad esordio infantile: iter diagnostico
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BRONTE, Vincenzo, CIRESI, Alessandro, CRISCIMANNA, Angela, MANTIONE, Lucilla Maria Grazia, PIZZOLANTI, Giuseppe, GALLUZZO, Aldo, MODICA, Giuseppe, GIORDANO, Carla, Richiusa P, Merlino S, Ficola U, Bronte V, Richiusa P, Ciresi A, Merlino S, Criscimanna A, Mantione L, Pizzolanti G, Galluzzo A, Modica G, Ficola U, and Giordano C
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MEN2B syndrome ,Settore MED/13 - Endocrinologia - Published
- 2004
5. Iter diagnostico 'rapido' per un caso di MEN IIb in un giovane adolescente
- Author
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FICOLA, U, MERLINO, S, RICHIUSA, P, BONO, M, MALATO, M, CIRESI, Alessandro, PIZZOLANTI, Giuseppe, BRONTE, Vincenzo, CRISCIMANNA, Angela, MANTIONE, Lucilla Maria Grazia, GALLUZZO, Aldo, GIORDANO, Carla, FICOLA, U, CIRESI, A, MERLINO, S, PIZZOLANTI, G, RICHIUSA, P, BONO, M, MALATO, M, BRONTE, V, CRISCIMANNA, A, MANTIONE, L, GALLUZZO, A, and GIORDANO, C
- Subjects
MEN IIB, CARCINOMA MIDOLLARE DELLA TIROIDE, FEOCROMOCITOMA, GENE RET ,Settore MED/13 - Endocrinologia - Published
- 2004
6. L’uso del hrTSH nel follow up del microcarcinoma tiroideo in pazienti sottoposti a tiroidectomia totale
- Author
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RICHIUSA, P, FICOLA, U, MERLINO, S, LI VOLSI, F, RODOLICO, V, AMATO, Marco Calogero, CRISCIMANNA, Angela, CITARRELLA, Roberto, MANTIONE, Lucilla Maria Grazia, BRONTE, Vincenzo, RUSSO, Leonardo, GRACEFFA, Giuseppa, LATTERI, Mario, MODICA, Giuseppe, GULOTTA, Gaspare, GALLUZZO, Aldo, GIORDANO, Carla, RICHIUSA, P, FICOLA, U, MERLINO, S, AMATO, A, CRISCIMANNA, A, CITARRELLA, R, MANTIONE, L, BRONTE, V, RUSSO, L, GRACEFFA, G, LI VOLSI, F, LATTERI, A, MODICA, G, GULOTTA, G, GALLUZZO, A, RODOLICO, V, and GIORDANO, C
- Subjects
CARCINOMA DELLA TIROIDE, hrTSH ,Settore MED/13 - Endocrinologia - Published
- 2004
7. Two-year survival prediction in patients with stage I and II non-small cell lung cancer utilizing 18F-FDG PET/CT SUV quantification
- Author
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Cistaro, A., Quartuccio, Natale, Mojtahedi, A., Fania, P., Filosso, P. L., Cucinotta, Mariapaola, Campenni', Alfredo, Ficola, U., and Baldari, Sergio
- Published
- 2013
8. Stage III-IV non small cell lung cancer: the impact of SUVmax and %SUVmax in predicting survival after chemotherapy
- Author
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Cistaro, A., Quartuccio, Natale, Mojtahedi, A., Fania, P., Cucinotta, Mariapaola, Campenni', Alfredo, Ficola, U., and Baldari, Sergio
- Published
- 2013
9. Is pre-treatment SUVmax an useful indicator of survival in patients with advanced non-small-cell lung cancer?
- Author
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Cistaro, A., Quartuccio, Natale, Mojtahedi, A., Fania, P., Filosso, P. L., Cucinotta, Mariapaola, Campenni', Alfredo, Ficola, U., and Baldari, Sergio
- Published
- 2013
10. 2 years-survival analysis of patients with non-small cell lung cancer by means of 2deoxy-2-[18F]fluoro-D-glucose positron emission tomography: implications of maximum standardized uptake value (SUVmax)
- Author
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Quartuccio, Natale, Cistaro, A., Campenni', Alfredo, Amato, Ernesto, Fania, P., Filosso, P. L., Ceraudo, F., Cucinotta, Mariapaola, Ficola, U., and Baldari, Sergio
- Published
- 2012
11. The Role of 2deoxy-2-[18F]fluoro-D-glucose Positron Emission Tomography and Maximum Standardized Uptake Value in Predicting Prognosis of patients Wihth Non-Small Cell Lug Cancer in Different Stages (I-IV)
- Author
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Quartuccio, Natale, Cistaro, A., Fania, P., Filosso, P., Ceraudo, F., Rimicci, A., Campenni', Alfredo, Ficola, U., and Baldari, Sergio
- Published
- 2011
12. Early chemotherapy intensification with BEACOPP in advanced-stage Hodgkin lymphoma patients with a interim-PET positive after two ABVD courses
- Author
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Gallamini, A, Patti, C, Viviani, S, Rossi, A, Fiore, F, DI RAIMONDO, Francesco, Cantonetti, M, Stelitano, C, Feldman, T, Gavarotti, P, Sorasio, R, Mulè, A, Leone, M, Rambaldi, A, Biggi, A, Barrington, S, Fallanca, F, Ficola, U, Chauvie, S, Gianni, Am, and FOR THE GRUPPO ITALIANO TERAPIE INNOVATIVE NEI LINFOMI GITIL
- Published
- 2011
13. Early chemotherapy intensification with BEACOPP in advanced-stage Hodgkin lymphoma patients with a interim-PET positive after two ABVD courses
- Author
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Gallamini A, Patti C, Viviani S, Rossi A, Fiore F, Di Raimondo F, Cantonetti M, Stelitano C, Feldman T, Gavarotti P, Sorasio R, Mulè A, Leone M, Rambaldi A, Biggi A, Barrington S, Fallanca F, Ficola U, Stephane Chauvie, and Am, Gianni
- Subjects
Adult ,Male ,Settore MED/06 - Oncologia Medica ,Drug Substitution ,Middle Aged ,Prognosis ,Vinblastine ,Hodgkin Disease ,Dacarbazine ,Bleomycin ,Treatment Outcome ,Doxorubicin ,Vincristine ,Positron-Emission Tomography ,Procarbazine ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Prednisone ,Female ,Epidemiologic Methods ,Settore MED/15 - Malattie del Sangue ,Cyclophosphamide ,Etoposide - Abstract
Interim 2-[18F]Fluoro-2-deoxy-D-glucose Positron Emission Tomography performed after two chemotherapy cycles (PET-2) is the most reliable predictor of treatment outcome in ABVD-treated Hodgkin Lymphoma (HL) patients. We retrospectively analysed the treatment outcome of a therapeutic strategy based on PET-2 results: positive patients switched to BEACOPP, while negative patients continued with ABVD. Between January 2006 and December 2007, 219 newly diagnosed HL patients admitted to nine centres were enrolled; 54 patients, unfit to receive this treatment were excluded from the analysis. PET-2 scans were reviewed by a central panel of nuclear medicine experts, according to the Deauville score (Meignan, 2009). After a median follow up of 34 months (12-52) the 2-year failure free survival (FFS) and overall survival for the entire cohort of 165 patients were 88% and 98%; the FFS was 65% for PET-2 positive and 92% for PET-2 negative patients. For 154 patients in which treatment was correctly given according to PET-2 review, the 2-year FFS was 91%: 62% for PET-2 positive and 95% for PET-2 negative patients.this strategy, with BEACOPP intensification only in PET-2 positive patients, showed better results than ABVD-treated historic controls, sparing BEACOPP toxicity to the majority of patients.
- Published
- 2010
14. 1408 POSTER DISCUSSION The Role of 2deoxy-2-[18F]fluoro-D-glucose Positron Emission Tomography and Maximum Standardized Uptake Value in Predicting Prognosis of Patients With Non-Small Cell Lung Cancer in Different Stages (l-IV)
- Author
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Quartuccio, N., primary, Cistaro, A., additional, Fania, P., additional, Filosso, P., additional, Ceraudo, F., additional, Rimicci, A., additional, Campenni, A., additional, Ficola, U., additional, and Baldari, S., additional
- Published
- 2011
- Full Text
- View/download PDF
15. Assessment of a New 18F-FDG PET/CT Protocol in the Staging of Oral Cavity Carcinomas
- Author
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Cistaro, A., primary, Palandri, S., additional, Balsamo, V., additional, Migliaretti, G., additional, Pentenero, M., additional, Testa, C., additional, Cusma, S., additional, Ceraudo, F., additional, Gandolfo, S., additional, and Ficola, U., additional
- Published
- 2011
- Full Text
- View/download PDF
16. Role of positron emission tomography (PET) in advanced stage non-small cell lung cancer patients treated with cisplatin-based doublets
- Author
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Gebbia, V., primary, Ficola, U., additional, Mancuso, G., additional, and La Maddalena, Arcara C., additional
- Published
- 2008
- Full Text
- View/download PDF
17. Quantitative comparison of technetium-99m tetrofosmin and thallium-201 images of the thyroid and abnormal parathyroid glands
- Author
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Giordano, Alessandro, Marozzi, P, Meduri, G, Ficola, U, Calcagni, Maria Lucia, Vaccaro, A, Rubini, G, Attard, M, Li Puma, M, Ricci, Riccardo, Corsello, Salvatore Maria, Giordano, Alessandro (ORCID:0000-0002-6978-0880), Calcagni, Ml (ORCID:0000-0002-0805-8245), Ricci, Riccardo (ORCID:0000-0002-9089-5084), Corsello, Salvatore Maria (ORCID:0000-0002-4544-7274), Giordano, Alessandro, Marozzi, P, Meduri, G, Ficola, U, Calcagni, Maria Lucia, Vaccaro, A, Rubini, G, Attard, M, Li Puma, M, Ricci, Riccardo, Corsello, Salvatore Maria, Giordano, Alessandro (ORCID:0000-0002-6978-0880), Calcagni, Ml (ORCID:0000-0002-0805-8245), Ricci, Riccardo (ORCID:0000-0002-9089-5084), and Corsello, Salvatore Maria (ORCID:0000-0002-4544-7274)
- Abstract
The aim of the study was to quantitatively compare the scintigraphic images of the thyroid and abnormal parathyroid glands obtained with technetium-99m tetrofosmin and thallium-201 in patients with hyperparathyroidism. Forty-six patients with hyperparathyroidism underwent (201)Tl (74 MBq), (99m)Tc-pertechnetate (74 MBq) and (99m)Tc-tetrofosmin (555-740 MBq) scintigraphy in a single session. Image analysis included the computation of the thyroid/background ratio in the whole study population and the parathyroid/background ratio, parathyroid/thyroid ratio and diagnostic sensitivity in 17 patients who underwent parathyroid surgery. The pertechnetate subtraction technique was used. (201)Tl and (99m)Tc-tetrofosmin showed a similar thyroid/background ratio (1.79+/-0.41 and 1.81+/-0. 47, respectively, P=NS); however, (99m)Tc-tetrofosmin showed a higher parathyroid/background ratio than (201)Tl (2.06+/-0.54 vs 1. 79+/- 0.50, P=0.007). Despite the superior quality of (99m)Tc-tetrofosmin images, both tracers showed identical sensitivity in detecting enlarged parathyroid glands in patients with primary hyperparathyroidism (89%) and in those with secondary hyperparathyroidism (50%).
- Published
- 1999
18. 51. Comparison of 99Tcm-tetrofosmin and 99Tcm-sestamibi in parathyroid scintigraphy
- Author
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Giordano, A., primary, Meduri, G., additional, Marozzi, P., additional, Ficola, U., additional, Cappagli, M., additional, Montepagani, A., additional, Rubini, G., additional, Giovine, G. Di, additional, and Ciavarella, G. Petracca, additional
- Published
- 1997
- Full Text
- View/download PDF
19. Neurophysiological and single photon emissiion tomography (SPET) in a patient with complex partial seizures in polytherapy
- Author
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Conti, A., primary, Castiglia, R., additional, and Ficola, U., additional
- Published
- 1995
- Full Text
- View/download PDF
20. Automatic quantitative analysis of 99mTc Sestamibi SPECT for the detection and assessment of extension of coronary artery disease (CAD). Multicentric protocol
- Author
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Campini, R., primary, Zoccarato, O., additional, Fringuelli, F., additional, Marcassa, C., additional, Romolo, G., additional, Cannizzaro, G., additional, Medolago, G., additional, Ficola, U., additional, Giubbini, R., additional, and Milan, E., additional
- Published
- 1995
- Full Text
- View/download PDF
21. Thymidine kinase level in cerebrospinal fluid of patients with leukemia
- Author
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Musto, P., Sergio Giuseppe Modoni, Longo, S., Ficola, U., Ritrovato, G., and Carotenuto, M.
22. Cerebro-spinal fluid thymidine kinase in acute leukemia
- Author
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Musto, P., Cascavilla, N., Ladogana, S., Longo, S., Sergio Giuseppe Modoni, Ficola, U., and Carotenuto, M.
23. SPECT of cerebral perfusion in neuroresuscitation. First experience | La scintitomografia (SPECT) della perfusione cerebrale in neurorianimazione. Prime esperienze
- Author
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Ciritella, P., Guido Valle, Giuliano, A. L., Modoni, S., Ficola, U., and Valeri, F.
24. Thymidine kinase in neoplastic haematological diseases: confirmations, doubts and new findings
- Author
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Pellegrino Musto, Longo, S., Morelli, A., Ficola, U., Falcone, A., and Carotenuto, M.
25. 51. Comparison of 99Tcm-tetrofosmin and 99Tcm-sestamibi in parathyroid scintigraphy.
- Author
-
Giordano, A., Meduri, G., Marozzi, P., Ficola, U., Cappagli, M., Montepagani, A., Rubini, G., Giovine, G. Di, and Ciavarella, G. Petracca
- Published
- 1997
- Full Text
- View/download PDF
26. 51 Comparison of 99Tcmtetrofosmin and 99Tcmsestamibi in parathyroid scintigraphy
- Author
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Giordano, A., Meduri, G., Marozzi, P., Ficola, U., Cappagli, M., Montepagani, A., Rubini, G., Giovine, G. Di, and Ciavarella, G. Petracca
- Published
- 1997
27. Whole-body MRI radiomics model to predict relapsed/refractory Hodgkin Lymphoma: A preliminary study
- Author
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Lorenzo Ugga, Domenico Albano, Massimo Galia, Umberto Ficola, Alessandro Costa, Renato Cuocolo, Massimo Midiri, Roberto Lagalla, Roberta Faraone, Giuseppe Micci, Silvia Albano, Vito Chianca, Vittoria Tarantino, Rosario Paratore, Caterina Patti, Albano D., Cuocolo R., Patti C., Ugga L., Chianca V., Tarantino V., Faraone R., Albano S., Micci G., Costa A., Paratore R., Ficola U., Lagalla R., Midiri M., Galia M., Albano, Domenico, Cuocolo, Renato, Patti, Caterina, Ugga, Lorenzo, Chianca, Vito, Tarantino, Vittoria, Faraone, Roberta, Albano, Silvia, Micci, Giuseppe, Costa, Alessandro, Paratore, Rosario, Ficola, Umberto, Lagalla, Roberto, Midiri, Massimo, and Galia, Massimo
- Subjects
Adult ,Positron emission tomography ,medicine.medical_specialty ,Whole body mri ,Biomedical Engineering ,Biophysics ,Vinblastine ,Bleomycin ,Young Adult ,Refractory ,Radiomics ,Positron Emission Tomography Computed Tomography ,Machine learning ,Antineoplastic Combined Chemotherapy Protocols ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Magnetic resonance imaging, Positron emission tomography, Machine learning, Texture analysis, Hodgkin Lymphoma ,medicine.diagnostic_test ,Hodgkin Lymphoma ,business.industry ,Magnetic resonance imaging ,Metabolic tumor volume ,Hodgkin Disease ,Magnetic Resonance Imaging ,Dacarbazine ,Texture analysis ,Doxorubicin ,Relapsed refractory ,Hodgkin lymphoma ,Female ,Radiology ,Settore MED/36 - Diagnostica Per Immagini E Radioterapia ,business - Abstract
Purpose A strong prognostic score that enables a stratification of newly diagnosed Hodgkin Lymphoma (HL) to identify patients at high risk of refractory/relapsed disease is still needed. Our aim was to investigate the potential value of a radiomics analysis pipeline from whole-body MRI (WB-MRI) exams for clinical outcome prediction in patients with Hodgkin Lymphoma (HL). Materials and methods Index lesions from baseline WB-MRIs of 40 patients (22 females; mean age 31.7 ± 11.4 years) with newly diagnosed HL treated by ABVD chemotherapy regimen were manually segmented on T1-weighted, STIR, and DWI images for texture analysis feature extraction. A machine learning approach based on the Extra Trees classifier and incorporating clinical variables, 18F-FDG-PET/CT-derived metabolic tumor volume, and WB-MRI radiomics features was tested using cross-validation to predict refractory/relapsed disease. Results Relapsed disease was observed in 10/40 patients (25%), two of whom died due to progression of disease and graft versus host disease, while eight reached the complete remission. In total, 1403 clinical and radiomics features were extracted, of which 11 clinical variables and 171 radiomics parameters from both original and filtered images were selected. The 3 best performing Extra Trees classifier models obtained an equivalent highest mean accuracy of 0.78 and standard deviation of 0.09, with a mean AUC of 0.82 and standard deviation of 0.08. Conclusions Our preliminary results demonstrate that a combined machine learning and texture analysis model to predict refractory/relapsed HL on WB-MRI exams is feasible and may help in the clinical outcome prediction in HL patients.
- Published
- 2021
28. Consolidation Radiotherapy Could Be Safely Omitted in Advanced Hodgkin Lymphoma With Large Nodal Mass in Complete Metabolic Response After ABVD: Final Analysis of the Randomized GITIL/FIL HD0607 Trial
- Author
-
Federico Fallanca, Roberto Sorasio, Umberto Ficola, Silvia Bolis, Guido Gini, Simonetta Viviani, Alessandra Romano, Piera Viero, Roberta Zanotti, Michele Cimminiello, Luca Guerra, Sara Oppi, Andrea Gallamini, Alessandro Rambaldi, Caterina Patti, Marco Picardi, Roberta Battistini, Livio Trentin, Andrea Rossi, Corrado Tarella, Corrado Schiavotto, Antonino Mulè, Maria Cantonetti, Chiara Pavoni, Stephane Chauvie, Gallamini, Andrea, Rossi, Andrea, Patti, Caterina, Picardi, Marco, Romano, Alessandra, Cantonetti, Maria, Oppi, Sara, Viviani, Simonetta, Bolis, Silvia, Trentin, Livio, Gini, Guido, Battistini, Roberta, Chauvie, Stephane, Sorasio, Roberto, Pavoni, Chiara, Zanotti, Roberta, Cimminiello, Michele, Schiavotto, Corrado, Viero, Piera, Mulé, Antonino, Fallanca, Federico, Ficola, Umberto, Tarella, Corrado, Guerra, Luca, Rambaldi, Alessandro, Gallamini, A, Rossi, A, Patti, C, Picardi, M, Romano, A, Cantonetti, M, Oppi, S, Viviani, S, Bolis, S, Trentin, L, Gini, G, Battistini, R, Chauvie, S, Sorasio, R, Pavoni, C, Zanotti, R, Cimminiello, M, Schiavotto, C, Viero, P, Mulé, A, Fallanca, F, Ficola, U, Tarella, C, Guerra, L, and Rambaldi, A
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Adolescent ,Lymphoma ,medicine.medical_treatment ,Kaplan-Meier Estimate ,Vinblastine ,law.invention ,Bleomycin ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Medicine ,Prospective Studies ,Progression-free survival ,Young adult ,Prospective cohort study ,radiotherapy ,Neoplasm Staging ,business.industry ,hodgkin lymphoma ,Middle Aged ,medicine.disease ,Hodgkin Disease ,Progression-Free Survival ,Dacarbazine ,Radiation therapy ,Oncology ,ABVD ,Doxorubicin ,030220 oncology & carcinogenesis ,Hodgkin lymphoma ,Female ,Lymph Nodes ,Radiology ,business ,030215 immunology ,medicine.drug - Abstract
PURPOSE To investigate the role of consolidation radiotherapy (cRT) in advanced-stage Hodgkin lymphoma (HL) presenting at baseline with a large nodal mass (LNM) in complete metabolic response after doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy. PATIENTS AND METHODS Advanced-stage (IIB-IVB) HL patients, enrolled in the HD 0607 trial (Clinicaltrial.gov identifier NCT00795613 ), with both a negative PET after two (PET-2) and six (PET-6) ABVD cycles, who presented at baseline with an LNM, defined as a nodal mass with the largest diameter ≥ 5 cm, were prospectively randomly assigned to receive cRT over the LNM or no further treatment (NFT). RESULTS Among 296 randomly assigned patients, the largest diameter of LNM at baseline was 5-7 cm in 101 (34%; subgroup A) and 8-10 cm in 96 (32%; subgroup B), whereas classic bulky (diameter > 10 cm) was detected in 99 (33%; subgroup C). Two hundred eighty patients (88%) showed a postchemotherapy RM. The median dose of cRT was 30.6 Gy (range, 24-36 Gy). After a median follow-up of 5.9 years (range, 0.5-10 years), the 6-year progression-free survival rate of patients who underwent cRT or NFT was, respectively, 91% (95% CI, 84% to 99%) and 95% (95% CI, 89% to 100%; P = .62) in subgroup A; 98% (95% CI, 93% to 100%) and 90% (95% CI, 80% to 100%; P = .24) in subgroup B; 89% (95% CI, 81% to 98%) and 86% (95% CI, 77% to 96%; P = .53) in subgroup C (classic bulky). CONCLUSION cRT could be safely omitted in patients with HL presenting with an LNM and a negative PET-2 and PET-6 scan, irrespective from the LNM size detected at baseline.
- Published
- 2020
29. Rest wall motion analysis of myocardial regions with stress ischemia detected only after Thallium reinjection
- Author
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Brambilla, M, Inglese, E, Cannizzaro, G, Carerj, S, Favretto, G, Ficola, U, Massa, D, and Tisselli, A
- Published
- 1995
- Full Text
- View/download PDF
30. Comparison between whole-body MRI with diffusion-weighted imaging and PET/CT in staging newly diagnosed FDG-avid lymphomas
- Author
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Umberto Ficola, Francesco Agnello, Massimo Midiri, Ludovico La Grutta, Emanuele Grassedonio, Antonino Mulè, Giorgio Cannizzaro, Massimo Galia, Roberto Lagalla, Domenico Albano, Caterina Patti, Albano, D., Patti, C., La Grutta, L., Agnello, F., Grassedonio, E., Mulè, A., Cannizzaro, G., Ficola, U., Lagalla, R., Midiri, M., and Galia, M.
- Subjects
Male ,Staging ,Lymphoma ,Multimodal Imaging ,030218 nuclear medicine & medical imaging ,0302 clinical medicine ,Whole Body Imaging ,Prospective Studies ,Stage (cooking) ,Computed tomography ,Aged, 80 and over ,medicine.diagnostic_test ,General Medicine ,Middle Aged ,Positron emission tomography ,030220 oncology & carcinogenesis ,Radiopharmaceutical ,Female ,Diffusion-weighted imaging ,Radiology ,Human ,medicine.drug ,Adult ,medicine.medical_specialty ,Adolescent ,Whole body imaging ,Reproducibility of Result ,Young Adult ,03 medical and health sciences ,Magnetic resonance imaging ,Fluorodeoxyglucose F18 ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Aged ,Neoplasm Staging ,Fluorodeoxyglucose ,PET-CT ,Ivermectin ,business.industry ,Reproducibility of Results ,medicine.disease ,Prospective Studie ,Diffusion Magnetic Resonance Imaging ,Positron-Emission Tomography ,Mantle cell lymphoma ,Radiopharmaceuticals ,Settore MED/36 - Diagnostica Per Immagini E Radioterapia ,Tomography, X-Ray Computed ,Nuclear medicine ,business - Abstract
Objectives To compare whole body-MRI (WB-MRI) with diffusion-weighted imaging and FDG-PET/CT in staging newly diagnosed FDG-avid lymphomas. Methods 68 patients (37 males, 31 females; median age 42 years; range 15–86 years) with histologically confirmed lymphoma (37 Classical Hodgkin, 16 Diffuse large B-cell, 10 Follicular, 5 Mantle cell) underwent both MRI and FDG-PET/CT before treatment. Ann Arbor stages obtained with WB-MRI and FDG-PET/CT were compared using Cohen’s k statistics. Moreover WB-MRI and FDG-PET/CT stages were compared with the pathological stages obtained after the diagnostic iter using also bone marrow and available biopsies if clinically indicated. Results The agreement between WB-MRI and FDG-PET/CT was excellent. WB-MRI stage was equal to those of FDG-PET/CT in 62/68 patients (91.2%). There was an excellent agreement between WB-MRI stage and pathological stage (63/68 patients; 92.6%), and between FDG-PET/CT and pathological stage (64/68 patients; 94.1%). The differences between the stages were more frequent in the patients with Mantle cell lymphoma. Conclusions WB-MRI can be considered as a promising technique for FDG-avid lymphoma staging.
- Published
- 2016
- Full Text
- View/download PDF
31. Whole-body MRI radiomics model to predict relapsed/refractory Hodgkin Lymphoma: A preliminary study.
- Author
-
Albano D, Cuocolo R, Patti C, Ugga L, Chianca V, Tarantino V, Faraone R, Albano S, Micci G, Costa A, Paratore R, Ficola U, Lagalla R, Midiri M, and Galia M
- Subjects
- Adult, Antineoplastic Combined Chemotherapy Protocols, Bleomycin therapeutic use, Dacarbazine therapeutic use, Doxorubicin therapeutic use, Female, Humans, Magnetic Resonance Imaging methods, Vinblastine therapeutic use, Young Adult, Hodgkin Disease diagnostic imaging, Hodgkin Disease drug therapy, Hodgkin Disease pathology, Positron Emission Tomography Computed Tomography methods
- Abstract
Purpose: A strong prognostic score that enables a stratification of newly diagnosed Hodgkin Lymphoma (HL) to identify patients at high risk of refractory/relapsed disease is still needed. Our aim was to investigate the potential value of a radiomics analysis pipeline from whole-body MRI (WB-MRI) exams for clinical outcome prediction in patients with HL., Materials and Methods: Index lesions from baseline WB-MRIs of 40 patients (22 females; mean age 31.7 ± 11.4 years) with newly diagnosed HL treated by ABVD chemotherapy regimen were manually segmented on T1-weighted, STIR, and DWI images for texture analysis feature extraction. A machine learning approach based on the Extra Trees classifier and incorporating clinical variables,
18 F-FDG-PET/CT-derived metabolic tumor volume, and WB-MRI radiomics features was tested using cross-validation to predict refractory/relapsed disease., Results: Relapsed disease was observed in 10/40 patients (25%), two of whom died due to progression of disease and graft versus host disease, while eight reached the complete remission. In total, 1403 clinical and radiomics features were extracted, of which 11 clinical variables and 171 radiomics parameters from both original and filtered images were selected. The 3 best performing Extra Trees classifier models obtained an equivalent highest mean accuracy of 0.78 and standard deviation of 0.09, with a mean AUC of 0.82 and standard deviation of 0.08., Conclusions: Our preliminary results demonstrate that a combined machine learning and texture analysis model to predict refractory/relapsed HL on WB-MRI exams is feasible and may help in the clinical outcome prediction in HL patients., (Copyright © 2021 Elsevier Inc. All rights reserved.)- Published
- 2022
- Full Text
- View/download PDF
32. Consolidation Radiotherapy Could Be Safely Omitted in Advanced Hodgkin Lymphoma With Large Nodal Mass in Complete Metabolic Response After ABVD: Final Analysis of the Randomized GITIL/FIL HD0607 Trial.
- Author
-
Gallamini A, Rossi A, Patti C, Picardi M, Romano A, Cantonetti M, Oppi S, Viviani S, Bolis S, Trentin L, Gini G, Battistini R, Chauvie S, Sorasio R, Pavoni C, Zanotti R, Cimminiello M, Schiavotto C, Viero P, Mulé A, Fallanca F, Ficola U, Tarella C, Guerra L, and Rambaldi A
- Subjects
- Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Bleomycin administration & dosage, Dacarbazine administration & dosage, Doxorubicin administration & dosage, Female, Hodgkin Disease metabolism, Hodgkin Disease pathology, Humans, Kaplan-Meier Estimate, Lymph Nodes pathology, Male, Middle Aged, Neoplasm Staging, Progression-Free Survival, Prospective Studies, Vinblastine administration & dosage, Young Adult, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Hodgkin Disease drug therapy, Hodgkin Disease radiotherapy
- Abstract
Purpose: To investigate the role of consolidation radiotherapy (cRT) in advanced-stage Hodgkin lymphoma (HL) presenting at baseline with a large nodal mass (LNM) in complete metabolic response after doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy., Patients and Methods: Advanced-stage (IIB-IVB) HL patients, enrolled in the HD 0607 trial (Clinicaltrial.gov identifier NCT00795613), with both a negative PET after two (PET-2) and six (PET-6) ABVD cycles, who presented at baseline with an LNM, defined as a nodal mass with the largest diameter ≥ 5 cm, were prospectively randomly assigned to receive cRT over the LNM or no further treatment (NFT)., Results: Among 296 randomly assigned patients, the largest diameter of LNM at baseline was 5-7 cm in 101 (34%; subgroup A) and 8-10 cm in 96 (32%; subgroup B), whereas classic bulky (diameter > 10 cm) was detected in 99 (33%; subgroup C). Two hundred eighty patients (88%) showed a postchemotherapy RM. The median dose of cRT was 30.6 Gy (range, 24-36 Gy). After a median follow-up of 5.9 years (range, 0.5-10 years), the 6-year progression-free survival rate of patients who underwent cRT or NFT was, respectively, 91% (95% CI, 84% to 99%) and 95% (95% CI, 89% to 100%; P = .62) in subgroup A; 98% (95% CI, 93% to 100%) and 90% (95% CI, 80% to 100%; P = .24) in subgroup B; 89% (95% CI, 81% to 98%) and 86% (95% CI, 77% to 96%; P = .53) in subgroup C (classic bulky)., Conclusion: cRT could be safely omitted in patients with HL presenting with an LNM and a negative PET-2 and PET-6 scan, irrespective from the LNM size detected at baseline.
- Published
- 2020
- Full Text
- View/download PDF
33. Early Chemotherapy Intensification With Escalated BEACOPP in Patients With Advanced-Stage Hodgkin Lymphoma With a Positive Interim Positron Emission Tomography/Computed Tomography Scan After Two ABVD Cycles: Long-Term Results of the GITIL/FIL HD 0607 Trial.
- Author
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Gallamini A, Tarella C, Viviani S, Rossi A, Patti C, Mulé A, Picardi M, Romano A, Cantonetti M, La Nasa G, Trentin L, Bolis S, Rapezzi D, Battistini R, Gottardi D, Gavarotti P, Corradini P, Cimminiello M, Schiavotto C, Parvis G, Zanotti R, Gini G, Ferreri AJM, Viero P, Miglino M, Billio A, Avigdor A, Biggi A, Fallanca F, Ficola U, Gregianin M, Chiaravalloti A, Prosperini G, Bergesio F, Chauvie S, Pavoni C, Gianni AM, and Rambaldi A
- Subjects
- Adolescent, Adult, Bleomycin administration & dosage, Cyclophosphamide administration & dosage, Dacarbazine administration & dosage, Doxorubicin administration & dosage, Etoposide administration & dosage, Feasibility Studies, Female, Hodgkin Disease diagnostic imaging, Hodgkin Disease mortality, Hodgkin Disease pathology, Humans, Lymph Nodes pathology, Lymphatic Metastasis, Male, Middle Aged, Positron Emission Tomography Computed Tomography, Prednisone administration & dosage, Procarbazine administration & dosage, Prospective Studies, Radiotherapy, Rituximab administration & dosage, Survival Analysis, Vinblastine administration & dosage, Vincristine administration & dosage, Young Adult, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Hodgkin Disease drug therapy
- Abstract
Purpose To investigate the progression-free survival (PFS) of patients with advanced Hodgkin lymphoma (HL) after a risk-adapted treatment strategy that was based on a positive positron emission tomography scan performed after two doxorubicin, vinblastine, vincristine, and dacarbazine (ABVD) cycles (PET2). Patients and Methods Patients with advanced-stage (IIB to IVB) HL were consecutively enrolled. After two ABVD cycles, PET2 was performed and centrally reviewed according to the Deauville five-point scale. Patients with a positive PET2 were randomly assigned to four cycles of escalated bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) followed by four cycles of standard BEACOPP with or without rituximab. Patients with a negative PET2 continued ABVD, and those with a large nodal mass at diagnosis (≥ 5 cm) in complete remission with a negative PET at the end of chemotherapy were randomly assigned to radiotherapy or no further treatment. The primary end point was 3-year PFS. Results Of 782 enrolled patients, 150 (19%) had a positive and 630 (81%) a negative PET2. The 3-year PFS of all patients was 82%. The 3-year PFS of those with a positive and negative PET2 was 60% and 87%, respectively ( P < .001). The 3-year PFS of patients with a positive PET2 assigned to BEACOPP with or without rituximab was 63% versus 57% ( P = .53). In 296 patients with both interim and post-ABVD-negative PET who had a large nodal mass at diagnosis, radiotherapy was randomly added after chemotherapy without a significant PFS improvement (97% v 93%, respectively; P = .29). The 3-year overall survival of all 782 patients was 97% (99% and 89% for PET2 negative and positive, respectively). Conclusion The PET-driven switch from ABVD to escalated BEACOPP is feasible and effective in high-risk patients with advanced-stage HL.
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- 2018
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34. Abdomen/pelvis computed tomography in staging of pediatric Hodgkin Lymphoma: is it always necessary?
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Farruggia P, Puccio G, Sala A, Todesco A, Terenziani M, Mura R, D'Amico S, Casini T, Mosa C, Pillon M, Boaro MP, Bottigliero G, Burnelli R, Consarino C, Fedeli F, Mascarin M, Perruccio K, Schiavello E, Trizzino A, Ficola U, Garaventa A, and Rossello M
- Subjects
- Female, Humans, Lymph Nodes pathology, Male, Multimodal Imaging, Neoplasm Staging, Positron Emission Tomography Computed Tomography, Positron-Emission Tomography, Sensitivity and Specificity, Abdomen pathology, Hodgkin Disease diagnostic imaging, Hodgkin Disease pathology, Pelvis pathology, Tomography, X-Ray Computed methods
- Abstract
The purpose of the study was to determine if abdomen/pelvis computed tomography (CT) can be safety omitted in the initial staging of a subgroup of children affected by Hodgkin Lymphoma (HL). Every participating center of A.I.E.O.P (Associazione Italiana di Ematologia ed Oncologia Pediatrica) sent local staging reports of 18F-fluorodeoxyglucose positron emission tomography (PET) and abdominal ultrasound (US) along with digital images of staging abdomen/pelvis CT to the investigation center where the CT scans were evaluated by an experienced pediatric radiologist. The local radiologist who performed the US was unaware of local CT and PET reports (both carried out after US), and the reviewer radiologist examining the CT images was unaware of local US, PET and CT reports. A new abdominal staging of 123 patients performed on the basis of local US report, local PET report, and centralized CT report was then compared to a simpler staging based on local US and PET. No additional lesion was discovered by CT in patients with abdomen/pelvis negativity in both US and PET or isolated spleen positivity in US (or US and PET), and so it seems that in the initial staging, abdomen/pelvis CT can be safety omitted in about 1/2 to 2/3 of children diagnosed with HL., (© 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
- Published
- 2016
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35. Nonossifying fibroma: A possible pitfall in F18-FD-PET/CT imaging of Hodgkin's disease.
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Pagano M, Berta M, Postini AM, Bianchi M, Del Prever AB, Defilippi C, Ficola U, and Cistaro A
- Abstract
A 14-year-old girl was examined for a right lateral neck swelling and radiographic mediastinal widening. Biopsy of a right supraclavicular lymph node demonstrated the nodular sclerosing form of Hodgkin's lymphoma. An 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (F18-FDG-PET/CT) study showed several pathological areas of lymph-node uptake in the upper mediastum and right distal tibia. Radiography of the tibia revealed a nonossifying fibroma in the site corresponding to the distal tibial uptake. The PET appearance of benign fibro-osseous lesions may be similar to those of skeletal metastases. Information obtained by the CT component of the PET/CT study and by conventional radiography can be useful in preventing erroneous interpretations of F18-FDG-PET uptake.
- Published
- 2015
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- View/download PDF
36. 124I-MIBG: a new promising positron-emitting radiopharmaceutical for the evaluation of neuroblastoma.
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Cistaro A, Quartuccio N, Caobelli F, Piccardo A, Paratore R, Coppolino P, Sperandeo A, Arnone G, and Ficola U
- Subjects
- Child, Female, Humans, Male, Multimodal Imaging, 3-Iodobenzylguanidine, Electrons, Neuroblastoma diagnostic imaging, Positron-Emission Tomography methods, Radiopharmaceuticals, Tomography, X-Ray Computed methods
- Abstract
Neuroblastoma is the most common extra-cranial solid tumor in pediatric patients. Despite the established role of 123I-MIBG and 131I-MIBG scintigraphy in this tumor, only limited data are available regarding the use of 124I-metaiodobenzylguanidine (MIBG) positron emission tomography (PET)/computed tomography (CT). We present our preliminary experience with 124I-MIBG PET/CT: two pediatric patients affected by neuroblastoma, who underwent 124I-MIBG PET/CT for pre-therapy distribution evaluation and restaging purposes. We aimed to evaluate whether 124I-MIBG PET/CT can detect as many or more neuroblastoma lesions than 123I/131I-MIBG imaging. Our cases show promising results, although further validation and standardization of 124I-MIBG PET/CT are required.
- Published
- 2015
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37. WIDEN: A tool for medical image management in multicenter clinical trials.
- Author
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Chauvie S, Biggi A, Stancu A, Cerello P, Cavallo A, Fallanca F, Ficola U, Gregianin M, Guerra UP, Chiaravalloti A, Schillaci O, and Gallamini A
- Subjects
- Humans, Clinical Trials as Topic, Diagnostic Imaging methods, Information Management
- Abstract
Background It has been proposed that in clinical trials in which the therapeutic strategy is driven by functional imaging, central review of the images should be done in real time. Purpose We report our experience with a new tool for image exchange and review, called Web-Based Imaging Diagnosis by Expert Network (WIDEN), which we implemented for the HD0607 prospective multicenter Italian clinical trial in which Hodgkin lymphoma treatment was adapted based on results of an interim positron emission tomography (PET) scan performed after the first two cycles of chemotherapy. Methods We used WIDEN for general management of the clinical trial, site imaging qualification, image exchange, workflow control, blinded independent central review, inter-observer variability assessment, consensus creation, audit, and statistical analysis. Results As of February 2013, the interim PET was available for 512 patients; upon central review, 103 of the scans were judged to be positive and 409 to be negative. The median scan uploading and downloading times were 1 min, 25 s and 1 min, 55 s, respectively; the average and median times for diagnosis exchange were 47 h, 53 min and 37 h, 43 min, respectively. The binary concordance between pairs of reviewers (Cohen's kappa) ranged from 0.72 to 0.85. The 5-point scale concordance among all reviewers (Krippendorf's alpha) was 0.77. Conclusions WIDEN proved to be an effective tool for medical imaging exchange and online review. Data security, simplicity, feasibility, and prompt scan review were demonstrated. Central reviews were completed promptly.
- Published
- 2014
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- View/download PDF
38. Is %ΔSUVmax a useful indicator of survival in patients with advanced nonsmall-cell lung cancer?
- Author
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Cistaro A, Quartuccio N, Mojtahedi A, Fania P, Filosso PL, Cucinotta M, Campennì A, Ficola U, and Baldari S
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Carcinoma, Non-Small-Cell Lung pathology, Lung Neoplasms pathology, Neoplasm Staging, Survival Analysis
- Abstract
Purpose: To investigate the impact of the maximum standardized uptake value (SUVmax), size of primary lung lesion, and %ΔSUVmax on outcome (overall survival (OS) and 2-year disease-free survival (2-year DFS)) of patients with advanced nonsmall-cell lung cancer (NSCLC)., Materials and Methods: 86 stage III-IV NSCLC patients underwent 18 F-FDGPET/CT, before and after chemotherapy, and were classified into subgroups according to the response criteria of the European Organization for Research and Treatment of Cancer. SUVmax values and tumor size with the best prognostic significance were searched. Correlation between the SUVmax value and the initial response to therapy (best response) and the relationship between %ΔSUVmax and OS were assessed., Results: In patients in PD (20/86), the average pretreatment SUVmax was 11.8 ± 5.23, and the mean size of the primary lesion was 43.35 mm ± 16.63. In SD, PR, and CR patients (66/86), the average pretreatment SUVmax was 12.7 ± 8.05, and the mean size of the primary lesion was 41.6 mm ± 21.15. Correlation was identified only for %ΔSUVmax; patients with PD (ΔSUVmax > +25%) showed a worse OS than patients with ΔSUVmax < +25% (CR, PR, and SD) (P = 0.0235)., Conclusions: In stage III-IV NSCLC, among the assessed factors, only %ΔSUVmax may be considered as a useful prognostic factor.
- Published
- 2013
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39. Prediction of 2 years-survival in patients with stage I and II non-small cell lung cancer utilizing (18)F-FDG PET/CT SUV quantification.
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Cistaro A, Quartuccio N, Mojtahedi A, Fania P, Filosso PL, Campenni A, Ficola U, and Baldari S
- Abstract
Background: The purpose of the study was to evaluate the correlation between the maximum standardized uptake value (SUVmax), size of primary lung lesion, disease-free survival (DFS) and overall survival (OS) in patients with stage I and II non-small cell lung cancer (NSCLC) in 2 years follow-up., Patients and Methods: Forty-nine patients with stage I-II NSCLC were included in this study. Pre-surgical 2-deoxy-2-[18F]fluoro-D-glucose positron-emission tomography ((18)F-FDG PET/CT) study was performed for all patients. The relationship between SUVmax, tumour size and clinical outcome was measured. The cut-off value for SUVmax and tumour size with the best prognostic significance, probability of DFS and the correlation between SUVmax and the response to therapy were calculated., Results: There was a statistically significant correlation between SUVmax and DFS (p = 0.029). The optimal cut-offs were 9.00 for SUVmax (p = 0.0013) and 30mm for tumour size (p = 0.0028). Patients with SUVmax > 9 and primary lesion size > 30 mm had an expected 2years-DFS of 37.5%, while this rose to 90% if the tumour was <30 mm and/or SUVmax was <9., Conclusions: In stage I-II, SUVmax and tumour size might be helpful to identify the subgroup of patients with high chance for recurrence.
- Published
- 2013
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- View/download PDF
40. A comparison between ¹⁸F-FDG PET/CT imaging and biological and radiological findings in restaging of hepatoblastoma patients.
- Author
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Cistaro A, Treglia G, Pagano M, Fania P, Bova V, Basso ME, Fagioli F, Ficola U, and Quartuccio N
- Subjects
- Child, Child, Preschool, Hepatoblastoma pathology, Humans, Liver Neoplasms pathology, Magnetic Resonance Imaging, Multimodal Imaging, Neoplasm Staging, Fluorodeoxyglucose F18, Hepatoblastoma diagnostic imaging, Liver Neoplasms diagnostic imaging, Positron-Emission Tomography, Tomography, X-Ray Computed
- Abstract
Background: In this study we retrospectively evaluated if ¹⁸F-FDG-PET/CT provided incremental diagnostic information over CI in a group of hepatoblastoma patients performing restaging., Procedure: Nine patients (mean age: 5.9 years; range: 3.1-12 years) surgically treated for hepatoblastoma were followed up by clinical examination, serum α-FP monitoring, and US. CI (CT or MRI) and PET/CT were performed in case of suspicion of relapse. Fine-needle aspiration biopsies (FNAB) were carried out for final confirmation if the results of CI, PET/CT, and/or α-FP levels were suggestive of relapse. PET/CT and CI findings were analyzed for comparison purposes, using FNAB as reference standard., Results: α-FP level was suggestive of disease recurrence in 8/9 patients. Biopsy was performed in 8/9 cases. CI and PET/CT resulted to be concordant in 5/9 patients (CI identified recurrence of disease, but ¹⁸F-FDG-PET/CT provided a better definition of disease extent); in 4/9 cases, CI diagnostic information resulted in negative findings, whereas PET/CT correctly detected recurrence of disease. ¹⁸F-FDG-PET/CT showed an agreement of 100% (8/8) with FNAB results., Conclusions: ¹⁸F-FDG-PET/CT scan seems to better assess HB patients with respect to CI and may provide incremental diagnostic value in the restaging of this group of patients.
- Published
- 2013
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41. Early chemotherapy intensification with BEACOPP in advanced-stage Hodgkin lymphoma patients with a interim-PET positive after two ABVD courses.
- Author
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Gallamini A, Patti C, Viviani S, Rossi A, Fiore F, Di Raimondo F, Cantonetti M, Stelitano C, Feldman T, Gavarotti P, Sorasio R, Mulè A, Leone M, Rambaldi A, Biggi A, Barrington S, Fallanca F, Ficola U, Chauvie S, and Gianni AM
- Subjects
- Adult, Bleomycin therapeutic use, Cyclophosphamide therapeutic use, Dacarbazine therapeutic use, Doxorubicin therapeutic use, Drug Substitution, Epidemiologic Methods, Etoposide therapeutic use, Female, Hodgkin Disease diagnostic imaging, Humans, Male, Middle Aged, Positron-Emission Tomography, Prednisone therapeutic use, Procarbazine therapeutic use, Prognosis, Treatment Outcome, Vinblastine therapeutic use, Vincristine therapeutic use, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Hodgkin Disease drug therapy
- Abstract
Unlabelled: Interim 2-[18F]Fluoro-2-deoxy-D-glucose Positron Emission Tomography performed after two chemotherapy cycles (PET-2) is the most reliable predictor of treatment outcome in ABVD-treated Hodgkin Lymphoma (HL) patients. We retrospectively analysed the treatment outcome of a therapeutic strategy based on PET-2 results: positive patients switched to BEACOPP, while negative patients continued with ABVD. Between January 2006 and December 2007, 219 newly diagnosed HL patients admitted to nine centres were enrolled; 54 patients, unfit to receive this treatment were excluded from the analysis. PET-2 scans were reviewed by a central panel of nuclear medicine experts, according to the Deauville score (Meignan, 2009). After a median follow up of 34 months (12-52) the 2-year failure free survival (FFS) and overall survival for the entire cohort of 165 patients were 88% and 98%; the FFS was 65% for PET-2 positive and 92% for PET-2 negative patients. For 154 patients in which treatment was correctly given according to PET-2 review, the 2-year FFS was 91%: 62% for PET-2 positive and 95% for PET-2 negative patients., Conclusions: this strategy, with BEACOPP intensification only in PET-2 positive patients, showed better results than ABVD-treated historic controls, sparing BEACOPP toxicity to the majority of patients., (© 2011 Blackwell Publishing Ltd.)
- Published
- 2011
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- View/download PDF
42. The role of sentinel lymph-node biopsy (SLNB) in the treatment of breast cancer.
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Marrazzo A, Taormina P, David M, Casà L, Lo Gerfo D, Noto A, Riili I, Ficola U, and Russo L
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Breast Neoplasms pathology, Breast Neoplasms surgery, Sentinel Lymph Node Biopsy
- Abstract
Sentinel lymph-node biopsy is an innovative method for axillary staging in breast cancer patients, based on the concept that information about the status of the entire lymphatic drainage from a tumour site could be obtained by identification and sampling of a "sentinel node". The aim of the study was to evaluate the impact of sentinel lymph-node biopsy in the management of patients with early invasive breast carcinoma. Three hundred and forty-one patients with primary invasive breast carcinoma measuring less than 2 cm (less than 3 cm from January 2001) and clinically negative axillary nodes were recruited into the study. Sentinel lymph-nodes were positive for metastases in 108/341 cases (31.7%). Micrometastases were found in 22 patients and isolated tumour cells in 1 case. The mean number of sentinel lymph-nodes removed was 1.8 per patient. The sentinel lymph-node was the only positive node in 57 of 108 patients (52.8%). The percentage of axillary recurrence in sentinel lymph-node-negative patients was 0%. The accuracy of sentinel lymph-node biopsy for axillary staging has been confirmed in many studies. Axillary recurrences after sentinel lymph-node biopsy range from 0 to 1.6% in many series, while axillary recurrence after axillary lymph-node dissection is about 0-3%. In our experience we observed no axillary recurrences in 233 patients with sentinel lymph-node biopsy alone, with a median follow-up of 33 months, confirming the accuracy of the procedure, and sentinel lymph-node-negative patients with sentinel lymph-node biopsy alone are no more at risk for axillary recurrences than those undergoing axillary lymph-node dissection.
- Published
- 2006
43. False-positive results of an iodine-131 whole-body scan caused by an ectopic kidney.
- Author
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Attard M, Marozzi P, Gambino L, Janní F, Salice P, Ficola U, and Giuffrida D
- Subjects
- False Positive Reactions, Humans, Lung Neoplasms diagnostic imaging, Lung Neoplasms secondary, Radionuclide Imaging, Thyroglobulin blood, Thyroid Neoplasms pathology, Choristoma diagnostic imaging, Iodine Radioisotopes pharmacokinetics, Kidney abnormalities, Kidney diagnostic imaging
- Published
- 2001
- Full Text
- View/download PDF
44. Quantitative comparison of technetium-99m tetrofosmin and thallium-201 images of the thyroid and abnormal parathyroid glands.
- Author
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Giordano A, Marozzi P, Meduri G, Ficola U, Calcagni ML, Vaccaro A, Rubini G, Attard M, Li Puma M, Ricci R, and Corsello S
- Subjects
- Adenoma diagnostic imaging, Female, Humans, Male, Parathyroid Glands diagnostic imaging, Parathyroid Neoplasms diagnostic imaging, Radionuclide Imaging, Radiopharmaceuticals, Sensitivity and Specificity, Sodium Pertechnetate Tc 99m, Hyperparathyroidism diagnostic imaging, Hyperparathyroidism, Secondary diagnostic imaging, Organophosphorus Compounds, Organotechnetium Compounds, Thallium Radioisotopes, Thyroid Gland diagnostic imaging
- Abstract
The aim of the study was to quantitatively compare the scintigraphic images of the thyroid and abnormal parathyroid glands obtained with technetium-99m tetrofosmin and thallium-201 in patients with hyperparathyroidism. Forty-six patients with hyperparathyroidism underwent (201)Tl (74 MBq), (99m)Tc-pertechnetate (74 MBq) and (99m)Tc-tetrofosmin (555-740 MBq) scintigraphy in a single session. Image analysis included the computation of the thyroid/background ratio in the whole study population and the parathyroid/background ratio, parathyroid/thyroid ratio and diagnostic sensitivity in 17 patients who underwent parathyroid surgery. The pertechnetate subtraction technique was used. (201)Tl and (99m)Tc-tetrofosmin showed a similar thyroid/background ratio (1.79+/-0.41 and 1.81+/-0. 47, respectively, P=NS); however, (99m)Tc-tetrofosmin showed a higher parathyroid/background ratio than (201)Tl (2.06+/-0.54 vs 1. 79+/- 0.50, P=0.007). Despite the superior quality of (99m)Tc-tetrofosmin images, both tracers showed identical sensitivity in detecting enlarged parathyroid glands in patients with primary hyperparathyroidism (89%) and in those with secondary hyperparathyroidism (50%).
- Published
- 1999
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45. [SPECT of cerebral perfusion in neuroresuscitation. First experience].
- Author
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Ciritella P, Valle G, Giuliano AL, Modoni S, Ficola U, and Valeri F
- Subjects
- Adult, Aged, Cerebrovascular Disorders physiopathology, Child, Glasgow Coma Scale, Humans, Middle Aged, Organotechnetium Compounds, Oximes, Technetium Tc 99m Exametazime, Cerebrovascular Circulation physiology, Cerebrovascular Disorders diagnostic imaging, Tomography, Emission-Computed, Single-Photon
- Published
- 1993
46. Increase of plasma beta endorphins in vasodepressor syncope.
- Author
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Perna GP, Ficola U, Salvatori MP, Stanislao M, Vigna C, Villella A, Russo A, Fanelli R, Paleani Vettori PG, and Loperfido F
- Subjects
- Adolescent, Adult, Child, Female, Humans, Male, Syncope physiopathology, Syncope blood, beta-Endorphin blood
- Published
- 1990
- Full Text
- View/download PDF
47. [Increase of plasma levels of beta-endorphin during maximum bicycle ergometry effort in sedentary and trained subjects].
- Author
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Perna GP, Stanislao M, De Rito V, Salvatori MP, Ficola U, Dicembrino F, Petti PP, Fanelli R, and Loperfido F
- Subjects
- Adult, Exercise Test, Heart Rate, Humans, Life Style, Male, Physical Education and Training, Exercise, beta-Endorphin blood
- Abstract
Plasmatic levels of beta-endorphin during maximal graded bicycle stress test were measured by RIA on extracted plasma in 10 well-trained (A group) and in 8 untrained subjects (C group). Blood samples were obtained at rest, at peak work load and at the third, 10th and 90th min of recovery. For every stress test the following were evaluated: exercise time, maximum work load, total work load, maximum double product and mean K (an index of velocity of heart rate recovery during the first three minutes after the exercise). Both groups A and C showed a significant rise in beta-endorphin activity at the third minute of recovery; the increase was significantly greater in trained rather than in sedentary subjects (p less than 0.01). Beta-endorphin release was closely related to mean K; no relationship was found between exercise time, maximum work load, total work load, maximum double product and beta-endorphin rise. Our data shows that a release of beta-endorphin occurs during the initial phase of recovery after a maximal stress test; beta-endorphin rise is greater in trained subjects and correlates with the speed of heart rate recovery, but has no relationship with the duration and the grade of the effort. Whether beta-endorphin increase plays a role in the rapid decrease of adrenergic tone which occurs after exercise or represents a secondary phenomenon remains to be determined.
- Published
- 1990
48. [Release of beta-endorphin and beta-lipotropin during submaximal exertion in sedentary and active subjects. Endogenous opiate peptides during exertion in sedentary and active subjects].
- Author
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Perna GP, Villella A, Stanislao M, Fanelli R, Ficola U, Varraso A, and Loperfido F
- Subjects
- Adult, Humans, Life Style, Male, Oxygen Consumption, Physical Exertion, beta-Endorphin blood, beta-Lipotropin blood
- Abstract
Some recent studies suggest that changes in the endogenous opioid peptides (POE) secretion during stress may be involved in various hemodynamic, respiratory and hormonal responses to exercise. To evaluate the relationship between fitness and POE release, 10 mixed-type exercise trained athletes (A) and 10 sedentary normal controls (C) were examined by bicycle stress testing; maximum oxygen uptake (VO2max) and peak work load (PWL) were greater in A than C (VO2max = 61.8 +/- 5.2 vs 40.2 +/- 6.1 ml/kg; PWL = 1525 +/- 229 vs 915 +/- 305 kgm.both p less than 0.01). After 24 hours A and C underwent rectangular bicycle stress testing (two 20' steps at 60% and 80% VO2max). Total plasmatic beta-endorphin (BEP) and its precursor beta-lipotropin (BLPH) were dosed by radioimmunoassay at rest, at 60% VO2max, at 80% VO2max and after complete recovery. Physical exercise caused a transient rise of BEP + BLPH plasma levels in both A and C. In A the increase was greater and occurred earlier than in C. The POE release under submaximal exercise showed a close correlation with oxygen uptake and therefore with fitness. This relation appeared in A at both low and high effort levels, whereas in C it was more strict at higher effort level. There results suggest that POE system play an important role in the adaptive mechanisms in sport practice.
- Published
- 1987
49. Cerebro-spinal fluid thymidine kinase in acute leukemia.
- Author
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Musto P, Cascavilla N, Ladogana S, Longo S, Modoni S, Ficola U, and Carotenuto M
- Subjects
- Humans, Leukemia, Myeloid, Acute cerebrospinal fluid, Precursor Cell Lymphoblastic Leukemia-Lymphoma cerebrospinal fluid, Leukemia, Myeloid, Acute enzymology, Precursor Cell Lymphoblastic Leukemia-Lymphoma enzymology, Thymidine Kinase cerebrospinal fluid
- Published
- 1989
50. Thymidine kinase in neoplastic haematological diseases: confirmations, doubts and new findings.
- Author
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Musto P, Longo S, Morelli A, Ficola U, Falcone A, and Carotenuto M
- Subjects
- Humans, Biomarkers, Tumor blood, Leukemia blood, Lymphoma blood, Thymidine Kinase blood
- Published
- 1988
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