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12 results on '"Fichera, Imma"'

1. Table S1 from A Genetic Vaccine Encoding Shared Cancer Neoantigens to Treat Tumors with Microsatellite Instability

Author

Leoni, Guido, primary, D'Alise, Anna Morena, primary, Cotugno, Gabriella, primary, Langone, Francesca, primary, Garzia, Irene, primary, De Lucia, Maria, primary, Fichera, Imma, primary, Vitale, Rosa, primary, Bignone, Veronica, primary, Tucci, Fabio Giovanni, primary, Mori, Federica, primary, Leuzzi, Adriano, primary, Di Matteo, Elena, primary, Troise, Fulvia, primary, Abbate, Adele, primary, Merone, Rossella, primary, Ruzza, Valentino, primary, Diodoro, Maria Grazia, primary, Yadav, Mahesh, primary, Gordon-Alonso, Monica, primary, Vanhaver, Cristophe, primary, Panigada, Maddalena, primary, Soprana, Elisa, primary, Siccardi, Antonio, primary, Folgori, Antonella, primary, Colloca, Stefano, primary, van der Bruggen, Pierre, primary, Nicosia, Alfredo, primary, Lahm, Armin, primary, Catanese, Maria Teresa, primary, and Scarselli, Elisa, primary

Published
2023
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2. Data from A Genetic Vaccine Encoding Shared Cancer Neoantigens to Treat Tumors with Microsatellite Instability

Author

Leoni, Guido, primary, D'Alise, Anna Morena, primary, Cotugno, Gabriella, primary, Langone, Francesca, primary, Garzia, Irene, primary, De Lucia, Maria, primary, Fichera, Imma, primary, Vitale, Rosa, primary, Bignone, Veronica, primary, Tucci, Fabio Giovanni, primary, Mori, Federica, primary, Leuzzi, Adriano, primary, Di Matteo, Elena, primary, Troise, Fulvia, primary, Abbate, Adele, primary, Merone, Rossella, primary, Ruzza, Valentino, primary, Diodoro, Maria Grazia, primary, Yadav, Mahesh, primary, Gordon-Alonso, Monica, primary, Vanhaver, Cristophe, primary, Panigada, Maddalena, primary, Soprana, Elisa, primary, Siccardi, Antonio, primary, Folgori, Antonella, primary, Colloca, Stefano, primary, van der Bruggen, Pierre, primary, Nicosia, Alfredo, primary, Lahm, Armin, primary, Catanese, Maria Teresa, primary, and Scarselli, Elisa, primary

Published
2023
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3. Supplementary Data from A Genetic Vaccine Encoding Shared Cancer Neoantigens to Treat Tumors with Microsatellite Instability

Author

Leoni, Guido, primary, D'Alise, Anna Morena, primary, Cotugno, Gabriella, primary, Langone, Francesca, primary, Garzia, Irene, primary, De Lucia, Maria, primary, Fichera, Imma, primary, Vitale, Rosa, primary, Bignone, Veronica, primary, Tucci, Fabio Giovanni, primary, Mori, Federica, primary, Leuzzi, Adriano, primary, Di Matteo, Elena, primary, Troise, Fulvia, primary, Abbate, Adele, primary, Merone, Rossella, primary, Ruzza, Valentino, primary, Diodoro, Maria Grazia, primary, Yadav, Mahesh, primary, Gordon-Alonso, Monica, primary, Vanhaver, Cristophe, primary, Panigada, Maddalena, primary, Soprana, Elisa, primary, Siccardi, Antonio, primary, Folgori, Antonella, primary, Colloca, Stefano, primary, van der Bruggen, Pierre, primary, Nicosia, Alfredo, primary, Lahm, Armin, primary, Catanese, Maria Teresa, primary, and Scarselli, Elisa, primary

Published
2023
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4. Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade

Author

D’Alise, Anna Morena, Leoni, Guido, Cotugno, Gabriella, Troise, Fulvia, Langone, Francesca, Fichera, Imma, De Lucia, Maria, Avalle, Lidia, Vitale, Rosa, Leuzzi, Adriano, Bignone, Veronica, Di Matteo, Elena, Tucci, Fabio Giovanni, Poli, Valeria, Lahm, Armin, Catanese, Maria Teresa, Folgori, Antonella, Colloca, Stefano, Nicosia, Alfredo, and Scarselli, Elisa

Published
2019
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5. LGALS3BP, lectin galactoside-binding soluble 3 binding protein, induces vascular endothelial growth factor in human breast cancer cells and promotes angiogenesis

Author

Piccolo, Enza, Tinari, Nicola, Semeraro, Daniela, Traini, Sara, Fichera, Imma, Cumashi, Albana, La Sorda, Rossana, Spinella, Francesca, Bagnato, Anna, Lattanzio, Rossano, D’Egidio, Maurizia, Di Risio, Annalisa, Stampolidis, Pavlos, Piantelli, Mauro, Natoli, Clara, Ullrich, Axel, and Iacobelli, Stefano

Published
2013
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6. A Genetic Vaccine Encoding Shared Cancer Neoantigens to Treat Tumors with Microsatellite Instability.

Author

UCL - SSS/DDUV/GECE - Génétique cellulaire, Leoni, Guido, D'Alise, Anna Morena, Cotugno, Gabriella, Langone, Francesca, Garzia, Irene, De Lucia, Maria, Fichera, Imma, Vitale, Rosa, Bignone, Veronica, Tucci, Fabio Giovanni, Mori, Federica, Leuzzi, Adriano, Di Matteo, Elena, Troise, Fulvia, Abbate, Adele, Merone, Rossella, Ruzza, Valentino, Diodoro, Maria Grazia, Yadav, Mahesh, Gordon-Alonso, Monica, Vanhaver, Christophe, Panigada, Maddalena, Soprana, Elisa, Siccardi, Antonio, Folgori, Antonella, Colloca, Stefano, Van Der Bruggen, Pierre, Nicosia, Alfredo, Lahm, Armin, Catanese, Maria Teresa, Scarselli, Elisa, UCL - SSS/DDUV/GECE - Génétique cellulaire, Leoni, Guido, D'Alise, Anna Morena, Cotugno, Gabriella, Langone, Francesca, Garzia, Irene, De Lucia, Maria, Fichera, Imma, Vitale, Rosa, Bignone, Veronica, Tucci, Fabio Giovanni, Mori, Federica, Leuzzi, Adriano, Di Matteo, Elena, Troise, Fulvia, Abbate, Adele, Merone, Rossella, Ruzza, Valentino, Diodoro, Maria Grazia, Yadav, Mahesh, Gordon-Alonso, Monica, Vanhaver, Christophe, Panigada, Maddalena, Soprana, Elisa, Siccardi, Antonio, Folgori, Antonella, Colloca, Stefano, Van Der Bruggen, Pierre, Nicosia, Alfredo, Lahm, Armin, Catanese, Maria Teresa, and Scarselli, Elisa

Abstract

Tumors with microsatellite instability (MSI) are caused by a defective DNA mismatch repair system that leads to the accumulation of mutations within microsatellite regions. Indels in microsatellites of coding genes can result in the synthesis of frameshift peptides (FSP). FSPs are tumor-specific neoantigens shared across patients with MSI. In this study, we developed a neoantigen-based vaccine for the treatment of MSI tumors. Genetic sequences from 320 MSI tumor biopsies and matched healthy tissues in The Cancer Genome Atlas database were analyzed to select shared FSPs. Two hundred nine FSPs were selected and cloned into nonhuman Great Ape Adenoviral and Modified Vaccinia Ankara vectors to generate a viral-vectored vaccine, referred to as Nous-209. Sequencing tumor biopsies of 20 independent patients with MSI colorectal cancer revealed that a median number of 31 FSPs out of the 209 encoded by the vaccine was detected both in DNA and mRNA extracted from each tumor biopsy. A relevant number of peptides encoded by the vaccine were predicted to bind patient HLA haplotypes. Vaccine immunogenicity was demonstrated in mice with potent and broad induction of FSP-specific CD8 and CD4 T-cell responses. Moreover, a vaccine-encoded FSP was processed by human antigen-presenting cells and was subsequently able to activate human CD8 T cells. Nous-209 is an "off-the-shelf" cancer vaccine encoding many neoantigens shared across sporadic and hereditary MSI tumors. These results indicate that Nous-209 can induce the optimal breadth of immune responses that might achieve clinical benefit to treat and prevent MSI tumors. SIGNIFICANCE: These findings demonstrate the feasibility of an "off-the-shelf" vaccine for treatment and prevention of tumors harboring frameshift mutations and neoantigenic peptides as a result of microsatellite instability.

Published
2020

8. A Genetic Vaccine Encoding Shared Cancer Neoantigens to Treat Tumors with Microsatellite Instability

Author

Leoni, Guido, primary, D'Alise, Anna Morena, additional, Cotugno, Gabriella, additional, Langone, Francesca, additional, Garzia, Irene, additional, De Lucia, Maria, additional, Fichera, Imma, additional, Vitale, Rosa, additional, Bignone, Veronica, additional, Tucci, Fabio Giovanni, additional, Mori, Federica, additional, Leuzzi, Adriano, additional, Di Matteo, Elena, additional, Troise, Fulvia, additional, Abbate, Adele, additional, Merone, Rossella, additional, Ruzza, Valentino, additional, Diodoro, Maria Grazia, additional, Yadav, Mahesh, additional, Gordon-Alonso, Monica, additional, Vanhaver, Cristophe, additional, Panigada, Maddalena, additional, Soprana, Elisa, additional, Siccardi, Antonio, additional, Folgori, Antonella, additional, Colloca, Stefano, additional, van der Bruggen, Pierre, additional, Nicosia, Alfredo, additional, Lahm, Armin, additional, Catanese, Maria Teresa, additional, and Scarselli, Elisa, additional

Published
2020
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9. Abstract B105: A cancer vaccine targeting many neoantigens is required for effective eradication of large tumors

Author

D'Alise, Anna Morena, primary, Leoni, Guido, additional, Cotugno, Gabriella, additional, Troise, Fulvia, additional, Langone, Francesca, additional, Fichera, Imma, additional, Lucia, Maria De, additional, Vitale, Rosa, additional, Leuzzi, Adriano, additional, Bignone, Veronica, additional, Matteo, Elena Di, additional, Tucci, Fabio Giovanni, additional, Avalle, Lidia, additional, Poli, Valeria, additional, Lahm, Armin, additional, Catanese, Maria Teresa, additional, Folgori, Antonella, additional, Colloca, Stefano, additional, Nicosia, Alfredo, additional, and Scarselli, Elisa, additional

Published
2019
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11. LGALS3BP, lectin galactoside-binding soluble 3 binding protein, induces vascular endothelial growth factor in human breast cancer cells and promotes angiogenesis

Author

Piccolo, Enza, primary, Tinari, Nicola, additional, Semeraro, Daniela, additional, Traini, Sara, additional, Fichera, Imma, additional, Cumashi, Albana, additional, La Sorda, Rossana, additional, Spinella, Francesca, additional, Bagnato, Anna, additional, Lattanzio, Rossano, additional, D’Egidio, Maurizia, additional, Di Risio, Annalisa, additional, Stampolidis, Pavlos, additional, Piantelli, Mauro, additional, Natoli, Clara, additional, Ullrich, Axel, additional, and Iacobelli, Stefano, additional

Published
2012
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12. Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade.

Author

D'Alise, Anna Morena, Leoni, Guido, Cotugno, Gabriella, Troise, Fulvia, Langone, Francesca, Fichera, Imma, De Lucia, Maria, Avalle, Lidia, Vitale, Rosa, Leuzzi, Adriano, Bignone, Veronica, Di Matteo, Elena, Tucci, Fabio Giovanni, Poli, Valeria, Lahm, Armin, Catanese, Maria Teresa, Folgori, Antonella, Colloca, Stefano, Nicosia, Alfredo, and Scarselli, Elisa

Abstract

Neoantigens (nAgs) are promising tumor antigens for cancer vaccination with the potential of inducing robust and selective T cell responses. Genetic vaccines based on Adenoviruses derived from non-human Great Apes (GAd) elicit strong and effective T cell-mediated immunity in humans. Here, we investigate for the first time the potency and efficacy of a novel GAd encoding multiple neoantigens. Prophylactic or early therapeutic vaccination with GAd efficiently control tumor growth in mice. In contrast, combination of the vaccine with checkpoint inhibitors is required to eradicate large tumors. Gene expression profile of tumors in regression shows abundance of activated tumor infiltrating T cells with a more diversified TCR repertoire in animals treated with GAd and anti-PD1 compared to anti-PD1. Data suggest that effectiveness of vaccination in the presence of high tumor burden correlates with the breadth of nAgs-specific T cells and requires concomitant reversal of tumor suppression by checkpoint blockade. Vaccination against neo-antigens has resulted in an effective antitumor response in several models. Here, the authors show that delivery of larger sets of neo-antigens using an adenovirus-based vaccination platform, results in much better tumor protection when combined with checkpoint blockade in a mouse model of advanced disease. [ABSTRACT FROM AUTHOR]

Published
2019
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