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1. Abdominal drainage after elective colorectal surgery: propensity score-matched retrospective analysis of an Italian cohort

Author: Guadagni, S, Catarci, M, Masedu, F, Karim, M, Clementi, M, Ruffo, G, Viola, M, Borghi, F, Baldazzi, G, Scatizzi, M, Pirozzi, F, Delrio, P, Garulli, G, Marini, P, Campagnacci, R, De Luca, R, Ficari, F, Sica, G, Scabini, S, Liverani, A, Caricato, M, Patriti, A, Mancini, S, Baiocchi, G, Santoro, R, Siquini, W, Guercioni, G, Basti, M, Pedrazzani, C, Totis, M, Carrara, A, Lucchi, A, Pavanello, M, Muratore, A, D'Ugo, S, Di Leo, A, Pignata, G, Elmore, U, Anania, G, Carlini, M, Corcione, F, Vettoretto, N, Longo, G, Sorrentino, M, Giuliani, A, Ferrari, G, Taglietti, L, Verzelli, A, Di Cosmo, M, Cavaliere, D, Milone, M, Rausei, S, Ciaccio, G, Tebala, G, Brisinda, G, Berti, S, Millo, P, Boni, L, Guerrieri, M, Persiani, R, Parini, D, Spinelli, A, Genna, M, Bottino, V, Coratti, A, Scala, D, Rivolta, U, Piccoli, M, Talarico, C, Roviello, F, Anastasi, A, Ettorre, G, Montuori, M, Mariani, P, de Manzini, N, Donini, A, Armellino, M, Feo, C, Guerriero, S, Costanzi, A, Marchesi, F, Cicetti, M, Ciano, P, Benedetti, M, Montemurro, L, Mattei, M, Belloni, E, Apa, D, Di Carlo, M, Bertocchi, E, Masini, G, Altamura, A, Rubichi, F, Cianflocca, D, Migliore, M, Cassini, D, Pandolfini, L, Falsetto, A, Sciuto, A, Pace, U, Bucci, A, Monari, F, Attina, G, Maurizi, A, Simone, M, Giudici, F, Cianchi, F, Sensi, B, Aprile, A, Soriero, D, Scarinci, A, Capolupo, G, Sisti, V, Ricci, M, Sagnotta, A, Molfino, S, Amodio, P, Cardinali, A, Cicconi, S, Marziali, I, Frazzini, D, Conti, C, Tamini, N, Braga, M, Motter, M, Tirone, G, Martorelli, G, Cacurri, A, Di Marco, C, Marsanic, P, Federico, N, Spampinato, M, Crepaz, L, Andreuccetti, J, Canfora, I, Maggi, G, Chiozza, M, Spoletini, D, Marcellinaro, R, Bracale, U, Peltrini, R, Di Nuzzo, M, Botteri, E, Santoni, S, Stefanoni, M, Del Vecchio, G, Magistro, C, Ruggiero, S, Birindelli, A, Budassi, A, Zigiotto, D, Solaini, L, Ercolani, G, De Palma, G, Tenconi, S, Locurto, P, Di Cintio, A, Chiarello, M, Cariati, M, Gennai, A, Grivon, M, Cassinotti, E, Ortenzi, M, Biondi, A, De Luca, M, Carrano, F, Fior, F, Ferronetti, A, Giuliani, G, Marino, G, Bertoglio, C, Pecchini, F, Greco, V, Piagnerelli, R, Canonico, G, Colasanti, M, Pinotti, E, Carminati, R, Osenda, E, Graziosi, L, De Martino, C, Ioia, G, Pindozzi, F, Organetti, L, Monteleone, M, Dalmonte, G, La Gioia, G, Guadagni S., Catarci M., Masedu F., Karim M. E., Clementi M., Ruffo G., Viola M. G., Borghi F., Baldazzi G., Scatizzi M., Pirozzi F., Delrio P., Garulli G., Marini P., Campagnacci R., De Luca R., Ficari F., Sica G., Scabini S., Liverani A., Caricato M., Patriti A., Mancini S., Baiocchi G. L., Santoro R., Siquini W., Guercioni G., Basti M., Pedrazzani C., Totis M., Carrara A., Lucchi A., Pavanello M., Muratore A., D'Ugo S., Di Leo A., Pignata G., Elmore U., Anania G., Carlini M., Corcione F., Vettoretto N., Longo G., Sorrentino M., Giuliani A., Ferrari G., Taglietti L., Verzelli A., Di Cosmo M., Cavaliere D., Milone M., Rausei S., Ciaccio G., Tebala G., Brisinda G., Berti S., Millo P., Boni L., Guerrieri M., Persiani R., Parini D., Spinelli A., Genna M., Bottino V., Coratti A., Scala D., Rivolta U., Piccoli M., Talarico C., Roviello F., Anastasi A., Ettorre G. M., Montuori M., Mariani P., de Manzini N., Donini A., Armellino M. F., Feo C., Guerriero S., Costanzi A., Marchesi F., Cicetti M., Ciano P., Benedetti M., Montemurro L. A., Mattei M. S., Belloni E., Apa D., Di Carlo M., Bertocchi E., Masini G., Altamura A., Rubichi F., Cianflocca D., Migliore M., Cassini D., Pandolfini L., Falsetto A., Sciuto A., Pace U., Bucci A. F., Monari F., Attina G. M., Maurizi A., Simone M., Giudici F., Cianchi F., Sensi B., Aprile A., Soriero D., Scarinci A., Capolupo G. T., Sisti V., Ricci M. L., Sagnotta A., Molfino S., Amodio P., Cardinali A., Cicconi S., Marziali I., Frazzini D., Conti C., Tamini N., Braga M., Motter M., Tirone G., Martorelli G., Cacurri A., Di Marco C., Marsanic P., Federico N. S. P., Spampinato M., Crepaz L., Andreuccetti J., Canfora I., Maggi G., Chiozza M., Spoletini D., Marcellinaro R., Bracale U., Peltrini R., Di Nuzzo M. M., Botteri E., Santoni S., Stefanoni M., Del Vecchio G., Magistro C., Ruggiero S., Birindelli A., Budassi A., Zigiotto D., Solaini L., Ercolani G., De Palma G. D., Tenconi S., Locurto P., Di Cintio A., Chiarello M. M., Cariati M., Gennai A., Grivon M., Cassinotti E., Ortenzi M., Biondi A., De Luca M., Carrano F., Fior F., Ferronetti A., Giuliani G., Marino G., Bertoglio C. L., Pecchini F., Greco V., Piagnerelli R., Canonico G., Colasanti M., Pinotti E., Carminati R., Osenda E., Graziosi L., De Martino C., Ioia G., Pindozzi F., Organetti L., Monteleone M., Dalmonte G., La Gioia G., Guadagni, S, Catarci, M, Masedu, F, Karim, M, Clementi, M, Ruffo, G, Viola, M, Borghi, F, Baldazzi, G, Scatizzi, M, Pirozzi, F, Delrio, P, Garulli, G, Marini, P, Campagnacci, R, De Luca, R, Ficari, F, Sica, G, Scabini, S, Liverani, A, Caricato, M, Patriti, A, Mancini, S, Baiocchi, G, Santoro, R, Siquini, W, Guercioni, G, Basti, M, Pedrazzani, C, Totis, M, Carrara, A, Lucchi, A, Pavanello, M, Muratore, A, D'Ugo, S, Di Leo, A, Pignata, G, Elmore, U, Anania, G, Carlini, M, Corcione, F, Vettoretto, N, Longo, G, Sorrentino, M, Giuliani, A, Ferrari, G, Taglietti, L, Verzelli, A, Di Cosmo, M, Cavaliere, D, Milone, M, Rausei, S, Ciaccio, G, Tebala, G, Brisinda, G, Berti, S, Millo, P, Boni, L, Guerrieri, M, Persiani, R, Parini, D, Spinelli, A, Genna, M, Bottino, V, Coratti, A, Scala, D, Rivolta, U, Piccoli, M, Talarico, C, Roviello, F, Anastasi, A, Ettorre, G, Montuori, M, Mariani, P, de Manzini, N, Donini, A, Armellino, M, Feo, C, Guerriero, S, Costanzi, A, Marchesi, F, Cicetti, M, Ciano, P, Benedetti, M, Montemurro, L, Mattei, M, Belloni, E, Apa, D, Di Carlo, M, Bertocchi, E, Masini, G, Altamura, A, Rubichi, F, Cianflocca, D, Migliore, M, Cassini, D, Pandolfini, L, Falsetto, A, Sciuto, A, Pace, U, Bucci, A, Monari, F, Attina, G, Maurizi, A, Simone, M, Giudici, F, Cianchi, F, Sensi, B, Aprile, A, Soriero, D, Scarinci, A, Capolupo, G, Sisti, V, Ricci, M, Sagnotta, A, Molfino, S, Amodio, P, Cardinali, A, Cicconi, S, Marziali, I, Frazzini, D, Conti, C, Tamini, N, Braga, M, Motter, M, Tirone, G, Martorelli, G, Cacurri, A, Di Marco, C, Marsanic, P, Federico, N, Spampinato, M, Crepaz, L, Andreuccetti, J, Canfora, I, Maggi, G, Chiozza, M, Spoletini, D, Marcellinaro, R, Bracale, U, Peltrini, R, Di Nuzzo, M, Botteri, E, Santoni, S, Stefanoni, M, Del Vecchio, G, Magistro, C, Ruggiero, S, Birindelli, A, Budassi, A, Zigiotto, D, Solaini, L, Ercolani, G, De Palma, G, Tenconi, S, Locurto, P, Di Cintio, A, Chiarello, M, Cariati, M, Gennai, A, Grivon, M, Cassinotti, E, Ortenzi, M, Biondi, A, De Luca, M, Carrano, F, Fior, F, Ferronetti, A, Giuliani, G, Marino, G, Bertoglio, C, Pecchini, F, Greco, V, Piagnerelli, R, Canonico, G, Colasanti, M, Pinotti, E, Carminati, R, Osenda, E, Graziosi, L, De Martino, C, Ioia, G, Pindozzi, F, Organetti, L, Monteleone, M, Dalmonte, G, La Gioia, G, Guadagni S., Catarci M., Masedu F., Karim M. E., Clementi M., Ruffo G., Viola M. G., Borghi F., Baldazzi G., Scatizzi M., Pirozzi F., Delrio P., Garulli G., Marini P., Campagnacci R., De Luca R., Ficari F., Sica G., Scabini S., Liverani A., Caricato M., Patriti A., Mancini S., Baiocchi G. L., Santoro R., Siquini W., Guercioni G., Basti M., Pedrazzani C., Totis M., Carrara A., Lucchi A., Pavanello M., Muratore A., D'Ugo S., Di Leo A., Pignata G., Elmore U., Anania G., Carlini M., Corcione F., Vettoretto N., Longo G., Sorrentino M., Giuliani A., Ferrari G., Taglietti L., Verzelli A., Di Cosmo M., Cavaliere D., Milone M., Rausei S., Ciaccio G., Tebala G., Brisinda G., Berti S., Millo P., Boni L., Guerrieri M., Persiani R., Parini D., Spinelli A., Genna M., Bottino V., Coratti A., Scala D., Rivolta U., Piccoli M., Talarico C., Roviello F., Anastasi A., Ettorre G. M., Montuori M., Mariani P., de Manzini N., Donini A., Armellino M. F., Feo C., Guerriero S., Costanzi A., Marchesi F., Cicetti M., Ciano P., Benedetti M., Montemurro L. A., Mattei M. S., Belloni E., Apa D., Di Carlo M., Bertocchi E., Masini G., Altamura A., Rubichi F., Cianflocca D., Migliore M., Cassini D., Pandolfini L., Falsetto A., Sciuto A., Pace U., Bucci A. F., Monari F., Attina G. M., Maurizi A., Simone M., Giudici F., Cianchi F., Sensi B., Aprile A., Soriero D., Scarinci A., Capolupo G. T., Sisti V., Ricci M. L., Sagnotta A., Molfino S., Amodio P., Cardinali A., Cicconi S., Marziali I., Frazzini D., Conti C., Tamini N., Braga M., Motter M., Tirone G., Martorelli G., Cacurri A., Di Marco C., Marsanic P., Federico N. S. P., Spampinato M., Crepaz L., Andreuccetti J., Canfora I., Maggi G., Chiozza M., Spoletini D., Marcellinaro R., Bracale U., Peltrini R., Di Nuzzo M. M., Botteri E., Santoni S., Stefanoni M., Del Vecchio G., Magistro C., Ruggiero S., Birindelli A., Budassi A., Zigiotto D., Solaini L., Ercolani G., De Palma G. D., Tenconi S., Locurto P., Di Cintio A., Chiarello M. M., Cariati M., Gennai A., Grivon M., Cassinotti E., Ortenzi M., Biondi A., De Luca M., Carrano F., Fior F., Ferronetti A., Giuliani G., Marino G., Bertoglio C. L., Pecchini F., Greco V., Piagnerelli R., Canonico G., Colasanti M., Pinotti E., Carminati R., Osenda E., Graziosi L., De Martino C., Ioia G., Pindozzi F., Organetti L., Monteleone M., Dalmonte G., and La Gioia G.
Abstract: Background: In Italy, surgeons continue to drain the abdominal cavity in more than 50 per cent of patients after colorectal resection. The aim of this study was to evaluate the impact of abdominal drain placement on early adverse events in patients undergoing elective colorectal surgery. Methods: A database was retrospectively analysed through a 1:1 propensity score-matching model including 21 covariates. The primary endpoint was the postoperative duration of stay, and the secondary endpoints were surgical site infections, infectious morbidity rate defined as surgical site infections plus pulmonary infections plus urinary infections, anastomotic leakage, overall morbidity rate, major morbidity rate, reoperation and mortality rates. The results of multiple logistic regression analyses were presented as odds ratios (OR) and 95 per cent c.i. Results: A total of 6157 patients were analysed to produce two well-balanced groups of 1802 patients: group (A), no abdominal drain(s) and group (B), abdominal drain(s). Group A versus group B showed a significantly lower risk of postoperative duration of stay >6 days (OR 0.60; 95 per cent c.i. 0.51–0.70; P < 0.001). A mean postoperative duration of stay difference of 0.86 days was detected between groups. No difference was recorded between the two groups for all the other endpoints. Conclusion: This study confirms that placement of abdominal drain(s) after elective colorectal surgery is associated with a non-clinically significant longer (0.86 days) postoperative duration of stay but has no impact on any other secondary outcomes, confirming that abdominal drains should not be used routinely in colorectal surgery.
Published: 2024

2. Mechanical bowel preparation in elective colorectal surgery: a propensity score-matched analysis of the Italian colorectal anastomotic leakage (iCral) study group prospective cohorts

Author: Catarci, M, Guadagni, S, Masedu, F, Ruffo, G, Viola, M, Borghi, F, Baldazzi, G, Pirozzi, F, Delrio, P, Garulli, G, Marini, P, Patriti, A, Campagnacci, R, Sica, G, Caricato, M, Montemurro, L, Ciano, P, Benedetti, M, Guercioni, G, Scatizzi, M, De Luca, R, Ficari, F, Scabini, S, Liverani, A, Mancini, S, Baiocchi, G, Santoro, R, Siquini, W, Basti, M, Pedrazzani, C, Totis, M, Carrara, A, Lucchi, A, Pavanello, M, Muratore, A, D'Ugo, S, Di Leo, A, Pignata, G, Elmore, U, Anania, G, Carlini, M, Corcione, F, Vettoretto, N, Longo, G, Sorrentino, M, Giuliani, A, Ferrari, G, Taglietti, L, Verzelli, A, Di Cosmo, M, Cavaliere, D, Milone, M, Rausei, S, Ciaccio, G, Tebala, G, Brisinda, G, Berti, S, Millo, P, Boni, L, Guerrieri, M, Persiani, R, Parini, D, Spinelli, A, Genna, M, Bottino, V, Coratti, A, Scala, D, Rivolta, U, Piccoli, M, Talarico, C, Roviello, F, Anastasi, A, Ettorre, G, Montuori, M, Mariani, P, de Manzini, N, Donini, A, Armellino, M, Feo, C, Guerriero, S, Costanzi, A, Marchesi, F, Cicetti, M, Mattei, M, Belloni, E, Apa, D, Di Carlo, M, Cicconi, S, Marziali, I, Clementi, M, Bertocchi, E, Masini, G, Altamura, A, Rubichi, F, Cianflocca, D, Migliore, M, Cassini, D, Sciuto, A, Pace, U, Bucci, A, Monari, F, Attina, G, Sisti, V, Ricci, M, Maurizi, A, Sensi, B, Capolupo, G, Pandolfini, L, Falsetto, A, Simone, M, Giudici, F, Cianchi, F, Baldini, G, Aprile, A, Soriero, D, Scarinci, A, Sagnotta, A, Molfino, S, Amodio, P, Cardinali, A, Frazzini, D, Conti, C, Tamini, N, Braga, M, Motter, M, Tirone, G, Martorelli, G, Cacurri, A, Di Marco, C, Marsanic, P, Federico, N, Spampinato, M, Crepaz, L, Andreuccetti, J, Canfora, I, Maggi, G, Chiozza, M, Spoletini, D, Marcellinaro, R, Lisi, G, Bracale, U, Peltrini, R, Di Nuzzo, M, Botteri, E, Santoni, S, Stefanoni, M, Del Vecchio, G, Magistro, C, Ruggiero, S, Birindelli, A, Budassi, A, Zigiotto, D, Solaini, L, Ercolani, G, De Palma, G, Tenconi, S, Locurto, P, Di Cintio, A, Chiarello, M, Cariati, M, Gennai, A, Grivon, M, Cassinotti, E, Ortenzi, M, Biondi, A, De Luca, M, Carrano, F, Fior, F, Ferronetti, A, Giuliani, G, Marino, G, Bertoglio, C, Pecchini, F, Greco, V, Piagnerelli, R, Canonico, G, Colasanti, M, Pinotti, E, Carminati, R, Osenda, E, Graziosi, L, De Martino, C, Ioia, G, Pindozzi, F, Organetti, L, Monteleone, M, Dalmonte, G, La Gioia, G, Catarci M., Guadagni S., Masedu F., Ruffo G., Viola M. G., Borghi F., Baldazzi G., Pirozzi F., Delrio P., Garulli G., Marini P., Patriti A., Campagnacci R., Sica G., Caricato M., Montemurro L. A., Ciano P., Benedetti M., Guercioni G., Scatizzi M., De Luca R., Ficari F., Scabini S., Liverani A., Mancini S., Baiocchi G. L., Santoro R., Siquini W., Basti M., Pedrazzani C., Totis M., Carrara A., Lucchi A., Pavanello M., Muratore A., D'Ugo S., Di Leo A., Pignata G., Elmore U., Anania G., Carlini M., Corcione F., Vettoretto N., Longo G., Sorrentino M., Giuliani A., Ferrari G., Taglietti L., Verzelli A., Di Cosmo M., Cavaliere D., Milone M., Rausei S., Ciaccio G., Tebala G., Brisinda G., Berti S., Millo P., Boni L., Guerrieri M., Persiani R., Parini D., Spinelli A., Genna M., Bottino V., Coratti A., Scala D., Rivolta U., Piccoli M., Talarico C., Roviello F., Anastasi A., Ettorre G. M., Montuori M., Mariani P., de Manzini N., Donini A., Armellino M. F., Feo C., Guerriero S., Costanzi A., Marchesi F., Cicetti M., Mattei M. S., Belloni E., Apa D., Di Carlo M., Cicconi S., Marziali I., Clementi M., Bertocchi E., Masini G., Altamura A., Rubichi F., Cianflocca D., Migliore M., Cassini D., Sciuto A., Pace U., Bucci A. F., Monari F., Attina G. M., Sisti V., Ricci M. L., Maurizi A., Sensi B., Capolupo G. T., Pandolfini L., Falsetto A., Simone M., Giudici F., Cianchi F., Baldini G., Aprile A., Soriero D., Scarinci A., Sagnotta A., Molfino S., Amodio P., Cardinali A., Frazzini D., Conti C., Tamini N., Braga M., Motter M., Tirone G., Martorelli G., Cacurri A., Di Marco C., Marsanic P., Federico N. S. P., Spampinato M., Crepaz L., Andreuccetti J., Canfora I., Maggi G., Chiozza M., Spoletini D., Marcellinaro R., Lisi G., Bracale U., Peltrini R., Di Nuzzo M. M., Botteri E., Santoni S., Stefanoni M., Del Vecchio G., Magistro C., Ruggiero S., Birindelli A., Budassi A., Zigiotto D., Solaini L., Ercolani G., De Palma G. D., Tenconi S., Locurto P., Di Cintio A., Chiarello M. M., Cariati M., Gennai A., Grivon M., Cassinotti E., Ortenzi M., Biondi A., De Luca M., Carrano F., Fior F., Ferronetti A., Giuliani G., Marino G., Bertoglio C. L., Pecchini F., Greco V., Piagnerelli R., Canonico G., Colasanti M., Pinotti E., Carminati R., Osenda E., Graziosi L., De Martino C., Ioia G., Pindozzi F., Organetti L., Monteleone M., Dalmonte G., La Gioia G., Catarci, M, Guadagni, S, Masedu, F, Ruffo, G, Viola, M, Borghi, F, Baldazzi, G, Pirozzi, F, Delrio, P, Garulli, G, Marini, P, Patriti, A, Campagnacci, R, Sica, G, Caricato, M, Montemurro, L, Ciano, P, Benedetti, M, Guercioni, G, Scatizzi, M, De Luca, R, Ficari, F, Scabini, S, Liverani, A, Mancini, S, Baiocchi, G, Santoro, R, Siquini, W, Basti, M, Pedrazzani, C, Totis, M, Carrara, A, Lucchi, A, Pavanello, M, Muratore, A, D'Ugo, S, Di Leo, A, Pignata, G, Elmore, U, Anania, G, Carlini, M, Corcione, F, Vettoretto, N, Longo, G, Sorrentino, M, Giuliani, A, Ferrari, G, Taglietti, L, Verzelli, A, Di Cosmo, M, Cavaliere, D, Milone, M, Rausei, S, Ciaccio, G, Tebala, G, Brisinda, G, Berti, S, Millo, P, Boni, L, Guerrieri, M, Persiani, R, Parini, D, Spinelli, A, Genna, M, Bottino, V, Coratti, A, Scala, D, Rivolta, U, Piccoli, M, Talarico, C, Roviello, F, Anastasi, A, Ettorre, G, Montuori, M, Mariani, P, de Manzini, N, Donini, A, Armellino, M, Feo, C, Guerriero, S, Costanzi, A, Marchesi, F, Cicetti, M, Mattei, M, Belloni, E, Apa, D, Di Carlo, M, Cicconi, S, Marziali, I, Clementi, M, Bertocchi, E, Masini, G, Altamura, A, Rubichi, F, Cianflocca, D, Migliore, M, Cassini, D, Sciuto, A, Pace, U, Bucci, A, Monari, F, Attina, G, Sisti, V, Ricci, M, Maurizi, A, Sensi, B, Capolupo, G, Pandolfini, L, Falsetto, A, Simone, M, Giudici, F, Cianchi, F, Baldini, G, Aprile, A, Soriero, D, Scarinci, A, Sagnotta, A, Molfino, S, Amodio, P, Cardinali, A, Frazzini, D, Conti, C, Tamini, N, Braga, M, Motter, M, Tirone, G, Martorelli, G, Cacurri, A, Di Marco, C, Marsanic, P, Federico, N, Spampinato, M, Crepaz, L, Andreuccetti, J, Canfora, I, Maggi, G, Chiozza, M, Spoletini, D, Marcellinaro, R, Lisi, G, Bracale, U, Peltrini, R, Di Nuzzo, M, Botteri, E, Santoni, S, Stefanoni, M, Del Vecchio, G, Magistro, C, Ruggiero, S, Birindelli, A, Budassi, A, Zigiotto, D, Solaini, L, Ercolani, G, De Palma, G, Tenconi, S, Locurto, P, Di Cintio, A, Chiarello, M, Cariati, M, Gennai, A, Grivon, M, Cassinotti, E, Ortenzi, M, Biondi, A, De Luca, M, Carrano, F, Fior, F, Ferronetti, A, Giuliani, G, Marino, G, Bertoglio, C, Pecchini, F, Greco, V, Piagnerelli, R, Canonico, G, Colasanti, M, Pinotti, E, Carminati, R, Osenda, E, Graziosi, L, De Martino, C, Ioia, G, Pindozzi, F, Organetti, L, Monteleone, M, Dalmonte, G, La Gioia, G, Catarci M., Guadagni S., Masedu F., Ruffo G., Viola M. G., Borghi F., Baldazzi G., Pirozzi F., Delrio P., Garulli G., Marini P., Patriti A., Campagnacci R., Sica G., Caricato M., Montemurro L. A., Ciano P., Benedetti M., Guercioni G., Scatizzi M., De Luca R., Ficari F., Scabini S., Liverani A., Mancini S., Baiocchi G. L., Santoro R., Siquini W., Basti M., Pedrazzani C., Totis M., Carrara A., Lucchi A., Pavanello M., Muratore A., D'Ugo S., Di Leo A., Pignata G., Elmore U., Anania G., Carlini M., Corcione F., Vettoretto N., Longo G., Sorrentino M., Giuliani A., Ferrari G., Taglietti L., Verzelli A., Di Cosmo M., Cavaliere D., Milone M., Rausei S., Ciaccio G., Tebala G., Brisinda G., Berti S., Millo P., Boni L., Guerrieri M., Persiani R., Parini D., Spinelli A., Genna M., Bottino V., Coratti A., Scala D., Rivolta U., Piccoli M., Talarico C., Roviello F., Anastasi A., Ettorre G. M., Montuori M., Mariani P., de Manzini N., Donini A., Armellino M. F., Feo C., Guerriero S., Costanzi A., Marchesi F., Cicetti M., Mattei M. S., Belloni E., Apa D., Di Carlo M., Cicconi S., Marziali I., Clementi M., Bertocchi E., Masini G., Altamura A., Rubichi F., Cianflocca D., Migliore M., Cassini D., Sciuto A., Pace U., Bucci A. F., Monari F., Attina G. M., Sisti V., Ricci M. L., Maurizi A., Sensi B., Capolupo G. T., Pandolfini L., Falsetto A., Simone M., Giudici F., Cianchi F., Baldini G., Aprile A., Soriero D., Scarinci A., Sagnotta A., Molfino S., Amodio P., Cardinali A., Frazzini D., Conti C., Tamini N., Braga M., Motter M., Tirone G., Martorelli G., Cacurri A., Di Marco C., Marsanic P., Federico N. S. P., Spampinato M., Crepaz L., Andreuccetti J., Canfora I., Maggi G., Chiozza M., Spoletini D., Marcellinaro R., Lisi G., Bracale U., Peltrini R., Di Nuzzo M. M., Botteri E., Santoni S., Stefanoni M., Del Vecchio G., Magistro C., Ruggiero S., Birindelli A., Budassi A., Zigiotto D., Solaini L., Ercolani G., De Palma G. D., Tenconi S., Locurto P., Di Cintio A., Chiarello M. M., Cariati M., Gennai A., Grivon M., Cassinotti E., Ortenzi M., Biondi A., De Luca M., Carrano F., Fior F., Ferronetti A., Giuliani G., Marino G., Bertoglio C. L., Pecchini F., Greco V., Piagnerelli R., Canonico G., Colasanti M., Pinotti E., Carminati R., Osenda E., Graziosi L., De Martino C., Ioia G., Pindozzi F., Organetti L., Monteleone M., Dalmonte G., and La Gioia G.
Abstract: Retrospective evaluation of the effects of mechanical bowel preparation (MBP) on data derived from two prospective open-label observational multicenter studies in Italy regarding elective colorectal surgery. MBP for elective colorectal surgery remains a controversial issue with contrasting recommendations in current guidelines. The Italian ColoRectal Anastomotic Leakage (iCral) study group, therefore, decided to estimate the effects of no MBP (treatment variable) versus MBP for elective colorectal surgery. A total of 8359 patients who underwent colorectal resection with anastomosis were enrolled in two consecutive prospective studies in 78 surgical centers in Italy from January 2019 to September 2021. A retrospective PSMA was performed on 5455 (65.3%) cases after the application of explicit exclusion criteria to eliminate confounders. The primary endpoints were anastomotic leakage (AL) and surgical site infections (SSI) rates; the secondary endpoints included SSI subgroups, overall and major morbidity, reoperation, and mortality rates. Overall length of postoperative hospital stay (LOS) was also considered. Two well-balanced groups of 1125 patients each were generated: group A (No MBP, true population of interest), and group B (MBP, control population), performing a PSMA considering 21 covariates. Group A vs. group B resulted significantly associated with a lower risk of AL [42 (3.5%) vs. 73 (6.0%) events; OR 0.57; 95% CI 0.38–0.84; p = 0.005]. No difference was recorded between the two groups for SSI [73 (6.0%) vs. 85 (7.0%) events; OR 0.88; 95% CI 0.63–1.22; p = 0.441]. Regarding the secondary endpoints, no MBP resulted significantly associated with a lower risk of reoperation and LOS > 6 days. This study confirms that no MBP before elective colorectal surgery is significantly associated with a lower risk of AL, reoperation rate, and LOS < 6 days when compared with MBP.
Published: 2024

3. Three-row versus two-row circular staplers for left-sided colorectal anastomosis: a propensity score-matched analysis of the iCral 2 and 3 prospective cohorts

Author: Catarci, M, Guadagni, S, Masedu, F, Ruffo, G, Viola, M, Borghi, F, Baldazzi, G, Scatizzi, M, Pirozzi, F, Delrio, P, Garulli, G, Marini, P, Campagnacci, R, De Luca, R, Ficari, F, Sica, G, Scabini, S, Liverani, A, Caricato, M, Patriti, A, Mancini, S, Baiocchi, G, Santoro, R, Siquini, W, Guercioni, G, Basti, M, Pedrazzani, C, Totis, M, Carrara, A, Lucchi, A, Pavanello, M, Muratore, A, D'Ugo, S, Di Leo, A, Pignata, G, Elmore, U, Anania, G, Carlini, M, Corcione, F, Vettoretto, N, Longo, G, Sorrentino, M, Giuliani, A, Ferrari, G, Taglietti, L, Verzelli, A, Di Cosmo, M, Cavaliere, D, Milone, M, Rausei, S, Ciaccio, G, Tebala, G, Brisinda, G, Berti, S, Millo, P, Boni, L, Guerrieri, M, Persiani, R, Parini, D, Spinelli, A, Genna, M, Bottino, V, Coratti, A, Scala, D, Rivolta, U, Piccoli, M, Talarico, C, Roviello, F, Anastasi, A, Ettorre, G, Montuori, M, Mariani, P, de Manzini, N, Donini, A, Armellino, M, Feo, C, Guerriero, S, Costanzi, A, Marchesi, F, Cicetti, M, Ciano, P, Benedetti, M, Montemurro, L, Mattei, M, Belloni, E, Apa, D, Di Carlo, M, Clementi, M, Bertocchi, E, Masini, G, Altamura, A, Rubichi, F, Cianflocca, D, Migliore, M, Cassini, D, Pandolfini, L, Falsetto, A, Sciuto, A, Pace, U, Bucci, A, Monari, F, Attina, G, Maurizi, A, Simone, M, Giudici, F, Cianchi, F, Baldini, G, Sensi, B, Aprile, A, Soriero, D, Scarinci, A, Capolupo, G, Sisti, V, Ricci, M, Sagnotta, A, Molfino, S, Amodio, P, Cardinali, A, Cicconi, S, Marziali, I, Frazzini, D, Conti, C, Tamini, N, Braga, M, Motter, M, Tirone, G, Martorelli, G, Cacurri, A, Di Marco, C, Marsanic, P, Federico, N, Spampinato, M, Crepaz, L, Andreuccetti, J, Canfora, I, Maggi, G, Chiozza, M, Spoletini, D, Marcellinaro, R, Lisi, G, Bracale, U, Peltrini, R, Di Nuzzo, M, Botteri, E, Santoni, S, Stefanoni, M, Del Vecchio, G, Magistro, C, Ruggiero, S, Birindelli, A, Budassi, A, Zigiotto, D, Solaini, L, Ercolani, G, De Palma, G, Tenconi, S, Locurto, P, Di Cintio, A, Chiarello, M, Cariati, M, Gennai, A, Grivon, M, Cassinotti, E, Ortenzi, M, Biondi, A, De Luca, M, Carrano, F, Fior, F, Ferronetti, A, Giuliani, G, Marino, G, Bertoglio, C, Pecchini, F, Greco, V, Piagnerelli, R, Canonico, G, Colasanti, M, Pinotti, E, Carminati, R, Osenda, E, Graziosi, L, De Martino, C, Ioia, G, Pindozzi, F, Organetti, L, Monteleone, M, Dalmonte, G, La Gioia, G, Catarci M., Guadagni S., Masedu F., Ruffo G., Viola M. G., Borghi F., Baldazzi G., Scatizzi M., Pirozzi F., Delrio P., Garulli G., Marini P., Campagnacci R., De Luca R., Ficari F., Sica G., Scabini S., Liverani A., Caricato M., Patriti A., Mancini S., Baiocchi G. L., Santoro R., Siquini W., Guercioni G., Basti M., Pedrazzani C., Totis M., Carrara A., Lucchi A., Pavanello M., Muratore A., D'Ugo S., Di Leo A., Pignata G., Elmore U., Anania G., Carlini M., Corcione F., Vettoretto N., Longo G., Sorrentino M., Giuliani A., Ferrari G., Taglietti L., Verzelli A., Di Cosmo M., Cavaliere D., Milone M., Rausei S., Ciaccio G., Tebala G., Brisinda G., Berti S., Millo P., Boni L., Guerrieri M., Persiani R., Parini D., Spinelli A., Genna M., Bottino V., Coratti A., Scala D., Rivolta U., Piccoli M., Talarico C., Roviello F., Anastasi A., Ettorre G. M., Montuori M., Mariani P., de Manzini N., Donini A., Armellino M. F., Feo C., Guerriero S., Costanzi A., Marchesi F., Cicetti M., Ciano P., Benedetti M., Montemurro L. A., Mattei M. S., Belloni E., Apa D., Di Carlo M., Clementi M., Bertocchi E., Masini G., Altamura A., Rubichi F., Cianflocca D., Migliore M., Cassini D., Pandolfini L., Falsetto A., Sciuto A., Pace U., Bucci A. F., Monari F., Attina G. M., Maurizi A., Simone M., Giudici F., Cianchi F., Baldini G., Sensi B., Aprile A., Soriero D., Scarinci A., Capolupo G. T., Sisti V., Ricci M. L., Sagnotta A., Molfino S., Amodio P., Cardinali A., Cicconi S., Marziali I., Frazzini D., Conti C., Tamini N., Braga M., Motter M., Tirone G., Martorelli G., Cacurri A., Di Marco C., Marsanic P., Federico N. S. P., Spampinato M., Crepaz L., Andreuccetti J., Canfora I., Maggi G., Chiozza M., Spoletini D., Marcellinaro R., Lisi G., Bracale U., Peltrini R., Di Nuzzo M. M., Botteri E., Santoni S., Stefanoni M., Del Vecchio G., Magistro C., Ruggiero S., Birindelli A., Budassi A., Zigiotto D., Solaini L., Ercolani G., De Palma G. D., Tenconi S., Locurto P., Di Cintio A., Chiarello M. M., Cariati M., Gennai A., Grivon M., Cassinotti E., Ortenzi M., Biondi A., De Luca M., Carrano F., Fior F., Ferronetti A., Giuliani G., Marino G., Bertoglio C. L., Pecchini F., Greco V., Piagnerelli R., Canonico G., Colasanti M., Pinotti E., Carminati R., Osenda E., Graziosi L., De Martino C., Ioia G., Pindozzi F., Organetti L., Monteleone M., Dalmonte G., La Gioia G., Catarci, M, Guadagni, S, Masedu, F, Ruffo, G, Viola, M, Borghi, F, Baldazzi, G, Scatizzi, M, Pirozzi, F, Delrio, P, Garulli, G, Marini, P, Campagnacci, R, De Luca, R, Ficari, F, Sica, G, Scabini, S, Liverani, A, Caricato, M, Patriti, A, Mancini, S, Baiocchi, G, Santoro, R, Siquini, W, Guercioni, G, Basti, M, Pedrazzani, C, Totis, M, Carrara, A, Lucchi, A, Pavanello, M, Muratore, A, D'Ugo, S, Di Leo, A, Pignata, G, Elmore, U, Anania, G, Carlini, M, Corcione, F, Vettoretto, N, Longo, G, Sorrentino, M, Giuliani, A, Ferrari, G, Taglietti, L, Verzelli, A, Di Cosmo, M, Cavaliere, D, Milone, M, Rausei, S, Ciaccio, G, Tebala, G, Brisinda, G, Berti, S, Millo, P, Boni, L, Guerrieri, M, Persiani, R, Parini, D, Spinelli, A, Genna, M, Bottino, V, Coratti, A, Scala, D, Rivolta, U, Piccoli, M, Talarico, C, Roviello, F, Anastasi, A, Ettorre, G, Montuori, M, Mariani, P, de Manzini, N, Donini, A, Armellino, M, Feo, C, Guerriero, S, Costanzi, A, Marchesi, F, Cicetti, M, Ciano, P, Benedetti, M, Montemurro, L, Mattei, M, Belloni, E, Apa, D, Di Carlo, M, Clementi, M, Bertocchi, E, Masini, G, Altamura, A, Rubichi, F, Cianflocca, D, Migliore, M, Cassini, D, Pandolfini, L, Falsetto, A, Sciuto, A, Pace, U, Bucci, A, Monari, F, Attina, G, Maurizi, A, Simone, M, Giudici, F, Cianchi, F, Baldini, G, Sensi, B, Aprile, A, Soriero, D, Scarinci, A, Capolupo, G, Sisti, V, Ricci, M, Sagnotta, A, Molfino, S, Amodio, P, Cardinali, A, Cicconi, S, Marziali, I, Frazzini, D, Conti, C, Tamini, N, Braga, M, Motter, M, Tirone, G, Martorelli, G, Cacurri, A, Di Marco, C, Marsanic, P, Federico, N, Spampinato, M, Crepaz, L, Andreuccetti, J, Canfora, I, Maggi, G, Chiozza, M, Spoletini, D, Marcellinaro, R, Lisi, G, Bracale, U, Peltrini, R, Di Nuzzo, M, Botteri, E, Santoni, S, Stefanoni, M, Del Vecchio, G, Magistro, C, Ruggiero, S, Birindelli, A, Budassi, A, Zigiotto, D, Solaini, L, Ercolani, G, De Palma, G, Tenconi, S, Locurto, P, Di Cintio, A, Chiarello, M, Cariati, M, Gennai, A, Grivon, M, Cassinotti, E, Ortenzi, M, Biondi, A, De Luca, M, Carrano, F, Fior, F, Ferronetti, A, Giuliani, G, Marino, G, Bertoglio, C, Pecchini, F, Greco, V, Piagnerelli, R, Canonico, G, Colasanti, M, Pinotti, E, Carminati, R, Osenda, E, Graziosi, L, De Martino, C, Ioia, G, Pindozzi, F, Organetti, L, Monteleone, M, Dalmonte, G, La Gioia, G, Catarci M., Guadagni S., Masedu F., Ruffo G., Viola M. G., Borghi F., Baldazzi G., Scatizzi M., Pirozzi F., Delrio P., Garulli G., Marini P., Campagnacci R., De Luca R., Ficari F., Sica G., Scabini S., Liverani A., Caricato M., Patriti A., Mancini S., Baiocchi G. L., Santoro R., Siquini W., Guercioni G., Basti M., Pedrazzani C., Totis M., Carrara A., Lucchi A., Pavanello M., Muratore A., D'Ugo S., Di Leo A., Pignata G., Elmore U., Anania G., Carlini M., Corcione F., Vettoretto N., Longo G., Sorrentino M., Giuliani A., Ferrari G., Taglietti L., Verzelli A., Di Cosmo M., Cavaliere D., Milone M., Rausei S., Ciaccio G., Tebala G., Brisinda G., Berti S., Millo P., Boni L., Guerrieri M., Persiani R., Parini D., Spinelli A., Genna M., Bottino V., Coratti A., Scala D., Rivolta U., Piccoli M., Talarico C., Roviello F., Anastasi A., Ettorre G. M., Montuori M., Mariani P., de Manzini N., Donini A., Armellino M. F., Feo C., Guerriero S., Costanzi A., Marchesi F., Cicetti M., Ciano P., Benedetti M., Montemurro L. A., Mattei M. S., Belloni E., Apa D., Di Carlo M., Clementi M., Bertocchi E., Masini G., Altamura A., Rubichi F., Cianflocca D., Migliore M., Cassini D., Pandolfini L., Falsetto A., Sciuto A., Pace U., Bucci A. F., Monari F., Attina G. M., Maurizi A., Simone M., Giudici F., Cianchi F., Baldini G., Sensi B., Aprile A., Soriero D., Scarinci A., Capolupo G. T., Sisti V., Ricci M. L., Sagnotta A., Molfino S., Amodio P., Cardinali A., Cicconi S., Marziali I., Frazzini D., Conti C., Tamini N., Braga M., Motter M., Tirone G., Martorelli G., Cacurri A., Di Marco C., Marsanic P., Federico N. S. P., Spampinato M., Crepaz L., Andreuccetti J., Canfora I., Maggi G., Chiozza M., Spoletini D., Marcellinaro R., Lisi G., Bracale U., Peltrini R., Di Nuzzo M. M., Botteri E., Santoni S., Stefanoni M., Del Vecchio G., Magistro C., Ruggiero S., Birindelli A., Budassi A., Zigiotto D., Solaini L., Ercolani G., De Palma G. D., Tenconi S., Locurto P., Di Cintio A., Chiarello M. M., Cariati M., Gennai A., Grivon M., Cassinotti E., Ortenzi M., Biondi A., De Luca M., Carrano F., Fior F., Ferronetti A., Giuliani G., Marino G., Bertoglio C. L., Pecchini F., Greco V., Piagnerelli R., Canonico G., Colasanti M., Pinotti E., Carminati R., Osenda E., Graziosi L., De Martino C., Ioia G., Pindozzi F., Organetti L., Monteleone M., Dalmonte G., and La Gioia G.
Abstract: Background: Since most anastomoses after left-sided colorectal resections are performed with a circular stapler, any technological change in stapling devices may influence the incidence of anastomotic adverse events. The aim of the present study was to analyze the effect of a three-row circular stapler on anastomotic leakage and related morbidity after left-sided colorectal resections. Materials and methods: A circular stapled anastomosis was performed in 4255 (50.9%) out of 8359 patients enrolled in two prospective multicenter studies in Italy, and, after exclusion criteria to reduce heterogeneity, 2799 (65.8%) cases were retrospectively analyzed through a 1:1 propensity score-matching model including 20 covariates relative to patient characteristics, to surgery and to perioperative management. Two well-balanced groups of 425 patients each were obtained: group (A) – true population of interest, anastomosis performed with a three-row circular stapler; group (B) – control population, anastomosis performed with a two-row circular stapler. The target of inferences was the average treatment effect in the treated (ATT). The primary endpoints were overall and major anastomotic leakage and overall anastomotic bleeding; the secondary endpoints were overall and major morbidity and mortality rates. The results of multiple logistic regression analyses for the outcomes, including the 20 covariates selected for matching, were presented as odds ratios (OR) and 95% confidence intervals (95% CI). Results: Group A versus group B showed a significantly lower risk of overall anastomotic leakage (2.1 vs. 6.1%; OR 0.33; 95% CI 0.15–0.73; P = 0.006), major anastomotic leakage (2.1 vs. 5.2%; OR 0.39; 95% CI 0.17–0.87; P = 0.022), and major morbidity (3.5 vs. 6.6% events; OR 0.47; 95% CI 0.24–0.91; P = 0.026). Conclusion: The use of three-row circular staplers independently reduced the risk of anastomotic leakage and related morbidity after left-sided colorectal resection. Twenty-five pati
Published: 2023

4. Implementing Enhanced Perioperative Care in Emergency General Surgery: A Prospective Multicenter Observational Study

Author: Ceresoli, M, Biloslavo, A, Bisagni, P, Ciuffa, C, Fortuna, L, La Greca, A, Tartaglia, D, Zago, M, Ficari, F, Foti, G, Braga, M, Armao, F, Bottari, A, Ballabio, M, Beretta, L, Bondi, C, Calcinati, S, Carlucci, M, Chiarugi, M, Ciravegna, A, Coccolini, F, Cozza, V, Cremonini, C, Ferraina, F, Fico, V, Fogliata, M, Germani, P, Gianotti, L, Grandi, S, Guiotto, L, Lena, E, Longhi, M, Lorenzi, I, Malagnino, A, Montino, M, Paiano, L, Pesenti, G, Riccadonna, S, Romanò, B, Russo, A, Somigli, R, Tomajer, V, Tripodi, V, Ceresoli M., Biloslavo A., Bisagni P., Ciuffa C., Fortuna L., La Greca A., Tartaglia D., Zago M., Ficari F., Foti G., Braga M., Armao F. T., Bottari A., Ballabio M., Beretta L., Bondi C., Calcinati S., Carlucci M., Chiarugi M., Ciravegna A. L., Coccolini F., Cozza V., Cremonini C., Ferraina F., Fico V., Fogliata M., Germani P., Gianotti L., Grandi S., Guiotto L., Lena E., Longhi M., Lorenzi I., Malagnino A., Montino M., Paiano L., Pesenti G., Riccadonna S., Romanò B., Russo A., Somigli R., Tomajer V., Tripodi V., Ceresoli, M, Biloslavo, A, Bisagni, P, Ciuffa, C, Fortuna, L, La Greca, A, Tartaglia, D, Zago, M, Ficari, F, Foti, G, Braga, M, Armao, F, Bottari, A, Ballabio, M, Beretta, L, Bondi, C, Calcinati, S, Carlucci, M, Chiarugi, M, Ciravegna, A, Coccolini, F, Cozza, V, Cremonini, C, Ferraina, F, Fico, V, Fogliata, M, Germani, P, Gianotti, L, Grandi, S, Guiotto, L, Lena, E, Longhi, M, Lorenzi, I, Malagnino, A, Montino, M, Paiano, L, Pesenti, G, Riccadonna, S, Romanò, B, Russo, A, Somigli, R, Tomajer, V, Tripodi, V, Ceresoli M., Biloslavo A., Bisagni P., Ciuffa C., Fortuna L., La Greca A., Tartaglia D., Zago M., Ficari F., Foti G., Braga M., Armao F. T., Bottari A., Ballabio M., Beretta L., Bondi C., Calcinati S., Carlucci M., Chiarugi M., Ciravegna A. L., Coccolini F., Cozza V., Cremonini C., Ferraina F., Fico V., Fogliata M., Germani P., Gianotti L., Grandi S., Guiotto L., Lena E., Longhi M., Lorenzi I., Malagnino A., Montino M., Paiano L., Pesenti G., Riccadonna S., Romanò B., Russo A., Somigli R., Tomajer V., and Tripodi V.
Abstract: Introduction: ERAS pathway has been proposed as the standard of care in elective abdominal surgery. Guidelines on ERAS in emergency surgery have been recently published; however, few evidences are still available in the literature. The aim of this study was to evaluate the feasibility of an enhanced recovery protocol in a large cohort of patients undergoing emergency surgery and to identify possible factors impacting postoperative protocol compliance. Methods: This is a prospective multicenter observational study including patients who underwent major emergency general surgery for either intra-abdominal infection or intestinal obstruction. The primary endpoint of the study is the adherence to ERAS postoperative protocol. Secondary endpoints are 30-day mortality and morbidity rates, and length of hospital stay. Results: A total of 589 patients were enrolled in the study, 256 (43.5%) of them underwent intestinal resection with anastomosis. Major complications occurred in 92 (15.6%) patients and 30-day mortality was 6.3%. Median adherence occurred on postoperative day (POD) 1 for naso-gastric tube removal, on POD 2 for mobilization and urinary catheter removal, and on POD 3 for oral intake and i.v. fluid suspension. Laparoscopy was significantly associated with adherence to postoperative protocol, whereas operative fluid infusion > 12 mL/Kg/h, preoperative hyperglycemia, presence of a drain, duration of surgery and major complications showed a negative association. Conclusions: The present study supports that an enhanced recovery protocol in emergency surgery is feasible and safe. Laparoscopy was associated with an earlier recovery, whereas preoperative hyperglycemia, fluid overload, and abdominal drain were associated with a delayed recovery.
Published: 2023

5. P988 Preliminary report on short-term post-operative outcomes of robotic versus laparoscopic approach for restorative procto-colectomy with ileal-pouch-anal anastomosis in ulcerative colitis: a comparative study

Author: Emma, E P, primary, Palleschi, C V, additional, Mariatti, M, additional, Minuzzo, A, additional, Perna, F, additional, Gia, E, additional, Ferrara, A, additional, Ficari, F, additional, and Scaringi, S, additional
Published: 2024
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6. P240 PREOPERATIVE OPTIMISATION FOR A PATIENT WITH HEART FAILURE UNDERGOING MAJOR NON–CARDIAC SURGERY: AN EXAMPLE OF COLLABORATION BETWEEN THE MULTIMODAL PREHABILITATION CENTRE AND THE HEART FAILURE CLINIC AT CAREGGI UNIVERSITY HOSPITAL

Author: Testa, G, primary, Livi, F, additional, Foti, L, additional, Verga, F, additional, Salucci, C, additional, D‘Errico, G, additional, Perini, E, additional, Fiorindi, C, additional, Cianchi, F, additional, Ficari, F, additional, Scaringi, S, additional, Tognozzi, C, additional, Amatucci, S, additional, Marmorale, S, additional, Ungar, A, additional, Romagnoli, S, additional, Orso, F, additional, Baldasseroni, S, additional, and Baldini, G, additional
Published: 2023
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7. Implementing Enhanced Perioperative Care in Emergency General Surgery: A Prospective Multicenter Observational Study

Author: Ceresoli M., Biloslavo A., Bisagni P., Ciuffa C., Fortuna L., La Greca A., Tartaglia D., Zago M., Ficari F., Foti G., Braga M., Armao F. T., Bottari A., Ballabio M., Beretta L., Bondi C., Calcinati S., Carlucci M., Chiarugi M., Ciravegna A. L., Coccolini F., Cozza V., Cremonini C., Ferraina F., Fico V., Fogliata M., Germani P., Gianotti L., Grandi S., Guiotto L., Lena E., Longhi M., Lorenzi I., Malagnino A., Montino M., Paiano L., Pesenti G., Riccadonna S., Romanò B., Russo A., Somigli R., Tomajer V., Tripodi V., Ceresoli, M, Biloslavo, A, Bisagni, P, Ciuffa, C, Fortuna, L, La Greca, A, Tartaglia, D, Zago, M, Ficari, F, Foti, G, Braga, M, Armao, F, Bottari, A, Ballabio, M, Beretta, L, Bondi, C, Calcinati, S, Carlucci, M, Chiarugi, M, Ciravegna, A, Coccolini, F, Cozza, V, Cremonini, C, Ferraina, F, Fico, V, Fogliata, M, Germani, P, Gianotti, L, Grandi, S, Guiotto, L, Lena, E, Longhi, M, Lorenzi, I, Malagnino, A, Montino, M, Paiano, L, Pesenti, G, Riccadonna, S, Romanò, B, Russo, A, Somigli, R, Tomajer, V, and Tripodi, V
Subjects: emergency surgery, era
Abstract: Introduction: ERAS pathway has been proposed as the standard of care in elective abdominal surgery. Guidelines on ERAS in emergency surgery have been recently published; however, few evidences are still available in the literature. The aim of this study was to evaluate the feasibility of an enhanced recovery protocol in a large cohort of patients undergoing emergency surgery and to identify possible factors impacting postoperative protocol compliance. Methods: This is a prospective multicenter observational study including patients who underwent major emergency general surgery for either intra-abdominal infection or intestinal obstruction. The primary endpoint of the study is the adherence to ERAS postoperative protocol. Secondary endpoints are 30-day mortality and morbidity rates, and length of hospital stay. Results: A total of 589 patients were enrolled in the study, 256 (43.5%) of them underwent intestinal resection with anastomosis. Major complications occurred in 92 (15.6%) patients and 30-day mortality was 6.3%. Median adherence occurred on postoperative day (POD) 1 for naso-gastric tube removal, on POD 2 for mobilization and urinary catheter removal, and on POD 3 for oral intake and i.v. fluid suspension. Laparoscopy was significantly associated with adherence to postoperative protocol, whereas operative fluid infusion > 12 mL/Kg/h, preoperative hyperglycemia, presence of a drain, duration of surgery and major complications showed a negative association. Conclusions: The present study supports that an enhanced recovery protocol in emergency surgery is feasible and safe. Laparoscopy was associated with an earlier recovery, whereas preoperative hyperglycemia, fluid overload, and abdominal drain were associated with a delayed recovery.
Published: 2023

8. Early Postoperative Low Compliance to Enhanced Recovery Pathway in Rectal Cancer Patients

Author: Ceresoli, M, Pedrazzani, C, Pellegrino, L, Muratore, A, Ficari, F, Polastri, R, Scatizzi, M, Totis, M, Tamini, N, Ripamonti, L, Braga, M, Ceresoli M., Pedrazzani C., Pellegrino L., Muratore A., Ficari F., Polastri R., Scatizzi M., Totis M., Tamini N., Ripamonti L., Braga M., Ceresoli, M, Pedrazzani, C, Pellegrino, L, Muratore, A, Ficari, F, Polastri, R, Scatizzi, M, Totis, M, Tamini, N, Ripamonti, L, Braga, M, Ceresoli M., Pedrazzani C., Pellegrino L., Muratore A., Ficari F., Polastri R., Scatizzi M., Totis M., Tamini N., Ripamonti L., and Braga M.
Abstract: Early postoperative low compliance to enhanced recovery protocols has been associated with morbidity following colon surgery. The purpose of this study is to evaluate the possible causes of early postoperative low compliance to the enhanced recovery pathway and its relationship with morbidity following rectal surgery for cancer. A total of 439 consecutive patients who underwent elective surgery for rectal cancer have been included in the study. Compliance to enhanced recovery protocol on postoperative day (POD) 2 was evaluated in all patients. Indicators of compliance were naso-gastric tube and urinary catheter removal, recovery of both oral feeding and mobilization, and the stopping of intravenous fluids. Low compliance on POD 2 was defined as non- adherence to two or more items. One-third of patients had low compliance on POD 2. Removal of urinary catheter, intravenous fluids stop, and mobilization were the items with lowest adherence. Advanced age, duration of surgery, open surgery and diverting stoma were predictive factors of low compliance at multivariate analysis. Overall morbidity and major complications were significantly higher (p < 0.001) in patients with low compliance on POD 2. At multivariate analysis, failure to remove urinary catheter on POD 2 (OR = 1.83) was significantly correlated with postoperative complications. Low compliance to enhanced recovery protocol on POD 2 was significantly associated with morbidity. Failure to remove the urinary catheter was the most predictive indicator. Advanced age, long procedure, open surgery and diverting stoma were independent predictive factors of low compliance.
Published: 2022

9. Early non compliance to enhanced recovery pathway might be an alert for underlying complications following colon surgery

Author: Ceresoli, M, Pedrazzani, C, Pellegrino, L, Ficari, F, Braga, M, Muratore, A, Tamini, N, Beretta, L, Azzola, M, Radrizzani, D, Borghi, F, Missana, G, Scatizzi, M, Totis, M, Crespi, M, Bima, C, Bouzari, H, Valenti, A, Ceretti, A, Polastri, R, Longhin, R, Maurizi, A, Cassini, D, Di Marzo, F, Fumagalli, S, Muratori, S, Casati, M, Ceresoli M., Pedrazzani C., Pellegrino L., Ficari F., Braga M., Muratore A., Tamini N., Beretta L., Azzola M., Radrizzani D., Borghi F., Missana G., Scatizzi M., Totis M., Crespi M., Bima C., Bouzari H., Valenti A., Ceretti A. P., Polastri R., Longhin R., Maurizi A., Cassini D., Di Marzo F., Fumagalli S., Muratori S., Casati M., Ceresoli, M, Pedrazzani, C, Pellegrino, L, Ficari, F, Braga, M, Muratore, A, Tamini, N, Beretta, L, Azzola, M, Radrizzani, D, Borghi, F, Missana, G, Scatizzi, M, Totis, M, Crespi, M, Bima, C, Bouzari, H, Valenti, A, Ceretti, A, Polastri, R, Longhin, R, Maurizi, A, Cassini, D, Di Marzo, F, Fumagalli, S, Muratori, S, Casati, M, Ceresoli M., Pedrazzani C., Pellegrino L., Ficari F., Braga M., Muratore A., Tamini N., Beretta L., Azzola M., Radrizzani D., Borghi F., Missana G., Scatizzi M., Totis M., Crespi M., Bima C., Bouzari H., Valenti A., Ceretti A. P., Polastri R., Longhin R., Maurizi A., Cassini D., Di Marzo F., Fumagalli S., Muratori S., and Casati M.
Abstract: Purpose: Early non compliance to postoperative ERAS pathway has been reported in 20–30% of patients who underwent elective colon surgery. The aim of the present study is to investigate the possible relationship between early non compliance and postoperative complications. Methods: We reviewed a prospective database including 1391 consecutively collected patients undergoing elective colon surgery in 22 Italian hospitals between January 2017 and June 2020. Early compliance to ERAS protocol was assessed on postoperative day (POD) 2. Failure of oral feeding, urinary catheter removal, intravenous fluids stop, and adequate mobilization were indicators of non compliance. Postoperative follow-up was carried out for 30 days after hospital discharge. The association among early postoperative ERAS compliance and the occurrence of complications was assessed with uni- and multivariate analysis. Results: A total of 1089 (78.3%) patients had malignancy and minimally invasive surgery was successfully performed in 1174 (84.3%) patients. Postoperative morbidity occurred in 403 (29.0%) patients. At multivariate analysis, male gender, open surgery, and each of the four non compliance indicators on POD 2 were significantly associated to postoperative complications. Morbidity progressively increased from 16.8% in patients with full compliance to ERAS protocol to 47.2% in patients with two non compliance indicators and 69.2% in patients with all four indicators (p < 0.001). Conclusions: Early non compliance to ERAS protocol was significantly associated with postoperative morbidity.
Published: 2022

10. OC.14.6 ATTITUDES TOWARDS VACCINATIONS IN AN ITALIAN COHORT OF IBD PATIENTS

Author: Costantino, A., primary, Michelon, M., additional, Noviello, D., additional, Leone, S., additional, Aloi, M., additional, Armuzzi, A., additional, Bossa, F., additional, Ficari, F., additional, Manguso, F., additional, Mocci, G., additional, Orlando, A., additional, Pironi, L., additional, Radice, S., additional, Rizzello, F., additional, Tongiorgi, A., additional, Costantino, C., additional, Vecchi, M., additional, and Caprioli, F.A., additional
Published: 2023
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11. P449 Minimally invasive IPAA in UC: Preliminary results from a referral center

Author: Fortuna, L, primary, Bottari, A, additional, Ficari, F, additional, Cricchio, M, additional, Cianchi, F, additional, and Scaringi, S, additional
Published: 2023
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12. Anastomosis configuration and technique following ileocaecal resection for Crohn’s disease: a multicentre study

Author: Celentano, V, Pellino, G, Spinelli, A, Selvaggi, F, SICCR Current status of Crohn’s disease surgery collaborative, Rottoli, M, Poggioli, G, Sica, G, Giglio, Mc, Campanelli, M, Coco, C, Rizzo, G, Sionne, F, Colombo, F, Sampietro, G, Lamperti, G, Foschi, D, Ficari, F, Vacca, L, Cricchio, M, Giudici, F, Selvaggi, L, Sciaudone, G, Peltrini, R, Manfreda, A, Bucci, L, Galleano, R, Ghazouani, O, Zorcolo, L, Deidda, S, Restivo, A, Braini, A, Di Candido, F, Sacchi, M, Carvello, M, Martorana, S, Bordignon, G, Angriman, I, Variola, A, Di Ruscio, M, Barugola, G, Geccherle, A, Tropeano, Fp, Luglio, G, Tanzanu, M, Sasia, D, Migliore, M, Giuffrida, Mc, Marrano, E, Moretto, G, Impellizzeri, H, Gallo, G, Vescio, G, Sammarco, G, Terrosu, G, Calini, G, Bondurri, A, Maffioli, A, Zaffaroni, G, Resegotti, A, Mistrangelo, M, Allaix, Me, Botti, F, Prati, M, Boni, L, Perotti, S, Mineccia, M, Giuliani, A, Romano, L, Graziano, Gmp, Pugliese, L, Pietrabissa, A, Delaini, G, on behalf of the Italian Society of Colorectal Surgery SICCR., Celentano, Valerio, Pellino, Gianluca, Spinelli, Antonino, Selvaggi, Francesco, Rottoli, Matteo, Poggioli, Gilberto, Sica, Giuseppe, Giglio, Mariano Cesare, Campanelli, Michela, Coco, Claudio, Rizzo, Gianluca, Sionne, Francesco, Colombo, Francesco, Sampietro, Gianluca, Lamperti, Giulia, Foschi, Diego, Ficari, Ferdinando, Vacca, Ludovica, Cricchio, Marta, Giudici, Francesco, Selvaggi, Lucio, Sciaudone, Guido, Peltrini, Roberto, Manfreda, Andrea, Bucci, Luigi, Galleano, Raffaele, Ghazouani, Omar, Zorcolo, Luigi, Deidda, Simona, Restivo, Angelo, Braini, Andrea, Di Candido, Francesca, Sacchi, Matteo, Carvello, Michele, Martorana, Stefania, Bordignon, Giovanni, Angriman, Imerio, Variola, Angela, Di Ruscio, Mirko, Barugola, Giuliano, Geccherle, Andrea, Tropeano, Francesca Paola, Luglio, Gaetano, Tanzanu, Marta, Sasia, Diego, Migliore, Marco, Giuffrida, Maria Carmela, Marrano, Enrico, Moretto, Gianluigi, Impellizzeri, Harmony, Gallo, Gaetano, Vescio, Giuseppina, Sammarco, Giuseppe, Terrosu, Giovanni, Calini, Giacomo, Bondurri, Andrea, Maffioli, Anna, Zaffaroni, Gloria, Resegotti, Andrea, Mistrangelo, Massimiliano, Allaix, Marco Ettore, Botti, Fiorenzo, Prati, Matteo, Boni, Luigi, Perotti, Serena, Mineccia, Michela, Giuliani, Antonio, Romano, Lucia, Graziano, Giorgio Maria Paolo, Pugliese, Luigi, Pietrabissa, Andrea, Delaini, GianGaetano, Celentano, V., Pellino, G., Spinelli, A., Selvaggi, F., Rottoli, M., Poggioli, G., Sica, G., Giglio, M. C., Campanelli, M., Coco, C., Rizzo, G., Sionne, F., Colombo, F., Sampietro, G., Lamperti, G., Foschi, D., Ficari, F., Vacca, L., Cricchio, M., Giudici, F., Selvaggi, L., Sciaudone, G., Peltrini, R., Manfreda, A., Bucci, L., Galleano, R., Ghazouani, O., Zorcolo, L., Deidda, S., Restivo, A., Braini, A., Di Candido, F., Sacchi, M., Carvello, M., Martorana, S., Bordignon, G., Angriman, I., Variola, A., Di Ruscio, M., Barugola, G., Geccherle, A., Tropeano, F. P., Luglio, G., Tanzanu, M., Sasia, D., Migliore, M., Giuffrida, M. C., Marrano, E., Moretto, G., Impellizzeri, H., Gallo, G., Vescio, G., Sammarco, G., Terrosu, G., Calini, G., Bondurri, A., Maffioli, A., Zaffaroni, G., Resegotti, A., Mistrangelo, M., Allaix, M. E., Botti, F., Prati, M., Boni, L., Perotti, S., Mineccia, M., Giuliani, A., Romano, L., Graziano, G. M. P., Pugliese, L., Pietrabissa, A., Delaini, G. G., Delaini, Giangaetano, Jinodg, G., Candido, F. D., and Ruscio, M. D.
Subjects: Ileocaecal resection, Male, Crohn’s disease, Leak, Settore MED/18 - CHIRURGIA GENERALE, Anastomotic Leak, Inflammatory bowel disease, Postoperative Complications, 0302 clinical medicine, Crohn Disease, Retrospective Studie, Surgical, 80 and over, Clinical endpoint, Colorectal surgery, National audit, Adolescent, Adult, Aged, Aged, 80 and over, Anastomosis, Surgical, Cecum, Digestive System Surgical Procedures, Elective Surgical Procedures, Female, Humans, Ileum, Laparoscopy, Length of Stay, Middle Aged, Reconstructive Surgical Procedures, Retrospective Studies, Treatment Outcome, Young Adult, Crohn's disease, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Human, medicine.medical_specialty, Anastomosis, 03 medical and health sciences, medicine, Performed Procedure, Reconstructive Surgical Procedure, colorectal surgery, national audit, Elective Surgical Procedure, business.industry, Digestive System Surgical Procedure, Plastic Surgery Procedures, medicine.disease, Settore MED/18, Surgery, Crohn’s disease · Inflammatory bowel disease · Ileocaecal resection · Colorectal surgery · National audit, Postoperative Complication, business
Abstract: A limited ileocaecal resection is the most frequently performed procedure for ileocaecal CD and different anastomotic configurations and techniques have been described. This manuscript audited the different anastomotic techniques used in a national study and evaluated their influence on postoperative outcomes following ileocaecal resection for primary CD. This is a retrospective, multicentre, observational study promoted by the Italian Society of Colorectal Surgery (SICCR), including all adults undergoing elective ileocaecal resection for primary CD from June 2018 May 2019. Postoperative morbidity within 30days of surgery was the primary endpoint. Postoperative length of hospital stay (LOS) and anastomotic leak rate were the secondary outcomes. 427 patients were included. The side to side anastomosis was the chosen configuration in 380 patients (89%). The stapled anastomotic (n = 286; 67%), techniques were preferred to hand-sewn (n = 141; 33%). Postoperative morbidity was 20.3% and anastomotic leak 3.7%. Anastomotic leak was independent of the type of anastomosis performed, while was associated with an ASA grade ≥ 3, presence of perianal disease and ileocolonic localization of disease. Four predictors of LOS were identified after multivariate analysis. The laparoscopic approach was the only associated with a reduced LOS (p = 0.017), while age, ASA grade ≥ 3 or administration of preoperative TPN were associated with increased LOS. The side to side was the most commonly used anastomotic configuration for ileocolic reconstruction following primary CD resection. There was no difference in postoperative morbidity according to anastomotic technique and configuration. Anastomotic leak was associated with ASA grade ≥ 3, a penetrating phenotype of disease and ileo-colonic distribution of CD. A limited ileocaecal resection is the most frequently performed procedure for ileocaecal CD and different anastomotic configurations and techniques have been described. This manuscript audited the different anastomotic techniques used in a national study and evaluated their influence on postoperative outcomes following ileocaecal resection for primary CD. This is a retrospective, multicentre, observational study promoted by the Italian Society of Colorectal Surgery (SICCR), including all adults undergoing elective ileocaecal resection for primary CD from June 2018 May 2019. Postoperative morbidity within 30days of surgery was the primary endpoint. Postoperative length of hospital stay (LOS) and anastomotic leak rate were the secondary outcomes. 427 patients were included. The side to side anastomosis was the chosen configuration in 380 patients (89%). The stapled anastomotic (n = 286; 67%), techniques were preferred to hand-sewn (n = 141; 33%). Postoperative morbidity was 20.3% and anastomotic leak 3.7%. Anastomotic leak was independent of the type of anastomosis performed, while was associated with an ASA grade ≥ 3, presence of perianal disease and ileocolonic localization of disease. Four predictors of LOS were identified after multivariate analysis. The laparoscopic approach was the only associated with a reduced LOS (p = 0.017), while age, ASA grade ≥ 3 or administration of preoperative TPN were associated with increased LOS. The side to side was the most commonly used anastomotic configuration for ileocolic reconstruction following primary CD resection. There was no difference in postoperative morbidity according to anastomotic technique and configuration. Anastomotic leak was associated with ASA grade ≥ 3, a penetrating phenotype of disease and ileo-colonic distribution of CD.
Published: 2021

13. Correction to: Single-incision laparoscopic surgery (SILS) for the treatment of ileocolonic Crohn’s disease: a propensity score–matched analysis (International Journal of Colorectal Disease, (2021), 36, 3, (605-608), 10.1007/s00384-020-03821-6)

Author: Celentano V., Pellino G., Rottoli M., Colombo F., Sampietro G., Spinelli A., Selvaggi F., Poggioli G., Sica G., Giglio M. C., Campanelli M., Coco C., Rizzo G., Sionne F., Lamperti G., Foschi D., Ficari F., Vacca L., Cricchio M., Giudici F., Selvaggi L., Sciaudone G., Peltrini R., Manfreda A., Bucci L., Galleano R., Ghazouani O., Zorcolo L., Deidda S., Restivo A., Braini A., Di Candido F., Sacchi M., Carvello M., Martorana S., Bordignon G., Angriman I., Variola A., Di Ruscio M., Barugola G., Geccherle A., Tropeano F. P., Luglio G., Tanzanu M., Sasia D., Migliore M., Giuffrida M. C., Marrano E., Moretto G., Impellizzeri H., Gallo G., Vescio G., Sammarco G., Terrosu G., Calini G., Bondurri A., Maffioli A., Zaffaroni G., Resegotti A., Mistrangelo M., Allaix M. E., Botti F., Prati M., Boni L., Perotti S., Mineccia M., Giuliani A., Romano L., Graziano G. M. P., Pugliese L., Pietrabissa A., Delaini G. G., Celentano, V., Pellino, G., Rottoli, M., Colombo, F., Sampietro, G., Spinelli, A., Selvaggi, F., Poggioli, G., Sica, G., Giglio, M. C., Campanelli, M., Coco, C., Rizzo, G., Sionne, F., Lamperti, G., Foschi, D., Ficari, F., Vacca, L., Cricchio, M., Giudici, F., Selvaggi, L., Sciaudone, G., Peltrini, R., Manfreda, A., Bucci, L., Galleano, R., Ghazouani, O., Zorcolo, L., Deidda, S., Restivo, A., Braini, A., Di Candido, F., Sacchi, M., Carvello, M., Martorana, S., Bordignon, G., Angriman, I., Variola, A., Di Ruscio, M., Barugola, G., Geccherle, A., Tropeano, F. P., Luglio, G., Tanzanu, M., Sasia, D., Migliore, M., Giuffrida, M. C., Marrano, E., Moretto, G., Impellizzeri, H., Gallo, G., Vescio, G., Sammarco, G., Terrosu, G., Calini, G., Bondurri, A., Maffioli, A., Zaffaroni, G., Resegotti, A., Mistrangelo, M., Allaix, M. E., Botti, F., Prati, M., Boni, L., Perotti, S., Mineccia, M., Giuliani, A., Romano, L., Graziano, G. M. P., Pugliese, L., Pietrabissa, A., and Delaini, G. G.
Abstract: All authors and affiliations of the SICCR Current status of Crohn’s disease surgery collaborative are listed in Appendix 1 and Specification of authors’ contribution is detailed in Appendix 2 of the original version of the above article however, the names were not cited nor reflected online. Thus, the namesarenowpresentedandcitedcorrectly.Allauthorstobe indexed on Pubmed. TheaffiliationofFrancescoColomboaco-authoroftheabove articleis affiliatedto“GeneralSurgeryUnit,Departmentof Biomedical and ClinicalSciences “L. Sacco”. University of Milan, AAST Fatebenefratelli Sacco, Milan, Italy” instead of “Division of General and HPB Surgery, Department of Surgery, ASST Rhodense- Rho Memorial Hospital,20017 Rho, Milan, Italy”. The original article has been corrected.
Published: 2021

14. Correction to: Single-incision laparoscopic surgery (SILS) for the treatment of ileocolonic Crohn’s disease: a propensity score–matched analysis (International Journal of Colorectal Disease, (2020), 10.1007/s00384-020-03821-6)

Author: Celentano, V., Pellino, G., Rottoli, M., Colombo, F., Sampietro, G., Spinelli, A., Selvaggi, F., Poggioli, G., Sica, G., Giglio, M. C., Campanelli, M., Coco, C., Rizzo, G., Sionne, F., Lamperti, G., Foschi, D., Ficari, F., Vacca, L., Cricchio, M., Giudici, F., Selvaggi, L., Sciaudone, G., Peltrini, R., Manfreda, A., Bucci, L., Galleano, R., Ghazouani, O., Zorcolo, L., Deidda, S., Restivo, A., Braini, A., Di Candido, F., Sacchi, M., Carvello, M., Martorana, S., Bordignon, G., Angriman, I., Variola, A., Di Ruscio, M., Barugola, G., Geccherle, A., Tropeano, F. P., Luglio, G., Tanzanu, M., Sasia, D., Migliore, M., Giuffrida, M. C., Marrano, E., Moretto, G., Impellizzeri, H., Gallo, G., Vescio, G., Sammarco, G., Terrosu, G., Calini, G., Bondurri, A., Maffioli, A., Zaffaroni, G., Resegotti, A., Mistrangelo, M., Allaix, M. E., Botti, F., Prati, M., Boni, L., Perotti, S., Mineccia, M., Giuliani, A., Romano, L., Graziano, G. M. P., Pugliese, L., Pietrabissa, A., Delaini, G. G., Celentano, V., Pellino, G., Rottoli, M., Colombo, F., Sampietro, G., Spinelli, A., Selvaggi, F., Poggioli, G., Sica, G., Giglio, M. C., Campanelli, M., Coco, C., Rizzo, G., Sionne, F., Lamperti, G., Foschi, D., Ficari, F., Vacca, L., Cricchio, M., Giudici, F., Selvaggi, L., Sciaudone, G., Peltrini, R., Manfreda, A., Bucci, L., Galleano, R., Ghazouani, O., Zorcolo, L., Deidda, S., Restivo, A., Braini, A., Di Candido, F., Sacchi, M., Carvello, M., Martorana, S., Bordignon, G., Angriman, I., Variola, A., Di Ruscio, M., Barugola, G., Geccherle, A., Tropeano, F. P., Luglio, G., Tanzanu, M., Sasia, D., Migliore, M., Giuffrida, M. C., Marrano, E., Moretto, G., Impellizzeri, H., Gallo, G., Vescio, G., Sammarco, G., Terrosu, G., Calini, G., Bondurri, A., Maffioli, A., Zaffaroni, G., Resegotti, A., Mistrangelo, M., Allaix, M. E., Botti, F., Prati, M., Boni, L., Perotti, S., Mineccia, M., Giuliani, A., Romano, L., Graziano, G. M. P., Pugliese, L., Pietrabissa, A., and Delaini, G. G.
Subjects: sils, crohn's disease, sils, crohn's disease, ileo-colonic, ileo-colonic
Abstract: All authors and affiliations of the SICCR Current status of Crohn’s disease surgery collaborative are listed in Appendix 1 and Specification of authors’ contribution is detailed in Appendix 2 of the original version of the above article however, the names were not cited nor reflected online. Thus, the names are now presented and cited correctly. All authors to be indexed on Pubmed. The original article has been corrected.
Published: 2021

15. P527 Telemedicine in IBD patients: results of a national survey of the Italian IBD patients’ association (AMICI Onlus)

Author: Costantino, A, primary, Caprioli, F, additional, Vecchi, M, additional, Stocco, D, additional, Aloi, M, additional, Armuzzi, A, additional, Ficari, F, additional, Manguso, F, additional, Mocci, G, additional, Orlando, A, additional, Pironi, L, additional, Radice, S, additional, Rizzello, F, additional, Tongiorgi, A, additional, Leone, S, additional, and Bossa, F, additional
Published: 2022
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16. AF.49 DETERMINANTS OF COVID-19 VACCINE HESITANCY IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE (IBD): RESULTS OF A NATIONAL SURVEY OF THE ITALIAN IBD PATIENTS’ ASSOCIATION (AMICI ONLUS)

Author: Costantino, A., primary, Noviello, D., additional, Conforti, F.S., additional, Aloi, M., additional, Armuzzi, A., additional, Bossa, F., additional, Ficari, F., additional, Leone, S., additional, Manguso, F., additional, Mocci, G., additional, Orlando, A., additional, Pironi, L., additional, Radice, S., additional, Rizzello, F., additional, Tongiorgi, A., additional, Costantino, C., additional, Vecchi, M., additional, and Caprioli, F., additional
Published: 2021
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17. P463 COVID-19 vaccination willingness and hesitancy in patients with Inflammatory Bowel Diseases (IBD): analysis of determinants in a national survey of the Italian IBD patients’ association (AMICI Onlus)

Author: Costantino, A, primary, Noviello, D, additional, Conforti, F S, additional, Aloi, M, additional, Armuzzi, A, additional, Bossa, F, additional, Ficari, F, additional, Leone, S, additional, Manguso, F, additional, Mocci, G, additional, Orlando, A, additional, Pironi, L, additional, Radice, S, additional, Rizzello, F, additional, Tongiorgi, A, additional, Costantino, C, additional, Vecchi, M, additional, and Caprioli, F, additional
Published: 2021
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18. Anastomosis configuration and technique following ileocaecal resection for Crohn’s disease: a multicentre study

Author: Celentano, V., Pellino, G., Spinelli, A., Selvaggi, F., Selvaggi, L., Sciaudone, G., Rottoli, M., Poggioli, G., Tanzanu, M., Sica, G., Campanelli, M., Giglio, M. C., Coco, C., Rizzo, G., Sionne, F., Colombo, F., Sampietro, G., Lamperti, G., Foschi, D., Ficari, F., Vacca, L., Cricchio, M., Giudici, F., Peltrini, R., Manfreda, A., Bucci, L., Galleano, R., Ghazouani, O., Zorcolo, L., Deidda, S., Restivo, A., Braini, A., Candido, F. D., Sacchi, M., Carvello, M., Martorana, S., Bordignon, G., Angriman, I., Variola, A., Ruscio, M. D., Barugola, G., Geccherle, A., Tropeano, F. P., Luglio, G., Sasia, D., Migliore, M., Giuffrida, M. C., Marrano, E., Moretto, G., Gallo, G., Vescio, G., Sammarco, G., Terrosu, G., Calini, G., Bondurri, A., Maffioli, A., Zaffaroni, G., Resegotti, A., Mistrangelo, M., Botti, F., Prati, M., Boni, L., Perotti, S., Mineccia, M., Giuliani, A., Romano, L., Graziano, G. M. P., Pugliese, L., Pietrabissa, A., Coco C. (ORCID:0000-0002-4713-7093), Rizzo G., Sionne F., Giuliani A. (ORCID:0000-0002-0773-2162), Celentano, V., Pellino, G., Spinelli, A., Selvaggi, F., Selvaggi, L., Sciaudone, G., Rottoli, M., Poggioli, G., Tanzanu, M., Sica, G., Campanelli, M., Giglio, M. C., Coco, C., Rizzo, G., Sionne, F., Colombo, F., Sampietro, G., Lamperti, G., Foschi, D., Ficari, F., Vacca, L., Cricchio, M., Giudici, F., Peltrini, R., Manfreda, A., Bucci, L., Galleano, R., Ghazouani, O., Zorcolo, L., Deidda, S., Restivo, A., Braini, A., Candido, F. D., Sacchi, M., Carvello, M., Martorana, S., Bordignon, G., Angriman, I., Variola, A., Ruscio, M. D., Barugola, G., Geccherle, A., Tropeano, F. P., Luglio, G., Sasia, D., Migliore, M., Giuffrida, M. C., Marrano, E., Moretto, G., Gallo, G., Vescio, G., Sammarco, G., Terrosu, G., Calini, G., Bondurri, A., Maffioli, A., Zaffaroni, G., Resegotti, A., Mistrangelo, M., Botti, F., Prati, M., Boni, L., Perotti, S., Mineccia, M., Giuliani, A., Romano, L., Graziano, G. M. P., Pugliese, L., Pietrabissa, A., Coco C. (ORCID:0000-0002-4713-7093), Rizzo G., Sionne F., and Giuliani A. (ORCID:0000-0002-0773-2162)
Abstract: A limited ileocaecal resection is the most frequently performed procedure for ileocaecal CD and different anastomotic configurations and techniques have been described. This manuscript audited the different anastomotic techniques used in a national study and evaluated their influence on postoperative outcomes following ileocaecal resection for primary CD. This is a retrospective, multicentre, observational study promoted by the Italian Society of Colorectal Surgery (SICCR), including all adults undergoing elective ileocaecal resection for primary CD from June 2018 May 2019. Postoperative morbidity within 30 days of surgery was the primary endpoint. Postoperative length of hospital stay (LOS) and anastomotic leak rate were the secondary outcomes. 427 patients were included. The side to side anastomosis was the chosen configuration in 380 patients (89%). The stapled anastomotic (n = 286; 67%), techniques were preferred to hand-sewn (n = 141; 33%). Postoperative morbidity was 20.3% and anastomotic leak 3.7%. Anastomotic leak was independent of the type of anastomosis performed, while was associated with an ASA grade ≥ 3, presence of perianal disease and ileocolonic localization of disease. Four predictors of LOS were identified after multivariate analysis. The laparoscopic approach was the only associated with a reduced LOS (p = 0.017), while age, ASA grade ≥ 3 or administration of preoperative TPN were associated with increased LOS. The side to side was the most commonly used anastomotic configuration for ileocolic reconstruction following primary CD resection. There was no difference in postoperative morbidity according to anastomotic technique and configuration. Anastomotic leak was associated with ASA grade ≥ 3, a penetrating phenotype of disease and ileo-colonic distribution of CD.
Published: 2021

19. National variations in perioperative assessment and surgical management of Crohn’s disease: a multicentre study

Author: Celentano, V., Pellino, G., Rottoli, M., Poggioli, G., Sica, G., Giglio, M. C., Campanelli, M., Coco, Claudio, Rizzo, Gianluca, Sionne, Francesco, Colombo, F., Sampietro, G., Lamperti, G., Foschi, D., Ficari, F., Vacca, L., Cricchio, M., Giudici, F., Selvaggi, L., Sciaudone, G., Peltrini, R., Manfreda, A., Bucci, L., Galleano, R., Ghazouani, O., Zorcolo, L., Deidda, S., Restivo, A., Braini, A., Di Candido, F., Sacchi, M., Carvello, M., Martorana, S., Bordignon, G., Angriman, I., Variola, A., Di Ruscio, M., Barugola, G., Geccherle, A., Tropeano, F. P., Luglio, G., Tanzanu, M., Sasia, D., Migliore, M., Giuffrida, M. C., Marrano, E., Moretto, G., Impellizzeri, H., Gallo, G., Vescio, G., Sammarco, G., Terrosu, G., Calini, G., Bondurri, A., Maffioli, A., Zaffaroni, G., Resegotti, A., Mistrangelo, M., Allaix, M. E., Botti, F., Prati, M., Boni, L., Perotti, S., Mineccia, M., Giuliani, A., Romano, L., Graziano, G. M. P., Pugliese, L., Pietrabissa, A., Delaini, G., Spinelli, A., Selvaggi, F., Coco C. (ORCID:0000-0002-4713-7093), Rizzo G., Sionne F., Celentano, V., Pellino, G., Rottoli, M., Poggioli, G., Sica, G., Giglio, M. C., Campanelli, M., Coco, Claudio, Rizzo, Gianluca, Sionne, Francesco, Colombo, F., Sampietro, G., Lamperti, G., Foschi, D., Ficari, F., Vacca, L., Cricchio, M., Giudici, F., Selvaggi, L., Sciaudone, G., Peltrini, R., Manfreda, A., Bucci, L., Galleano, R., Ghazouani, O., Zorcolo, L., Deidda, S., Restivo, A., Braini, A., Di Candido, F., Sacchi, M., Carvello, M., Martorana, S., Bordignon, G., Angriman, I., Variola, A., Di Ruscio, M., Barugola, G., Geccherle, A., Tropeano, F. P., Luglio, G., Tanzanu, M., Sasia, D., Migliore, M., Giuffrida, M. C., Marrano, E., Moretto, G., Impellizzeri, H., Gallo, G., Vescio, G., Sammarco, G., Terrosu, G., Calini, G., Bondurri, A., Maffioli, A., Zaffaroni, G., Resegotti, A., Mistrangelo, M., Allaix, M. E., Botti, F., Prati, M., Boni, L., Perotti, S., Mineccia, M., Giuliani, A., Romano, L., Graziano, G. M. P., Pugliese, L., Pietrabissa, A., Delaini, G., Spinelli, A., Selvaggi, F., Coco C. (ORCID:0000-0002-4713-7093), Rizzo G., and Sionne F.
Abstract: Aim: Crohn's disease (CD) requires a multidisciplinary approach and surgery should be undertaken by dedicated colorectal surgeons with audited outcomes. We present a national, multicentre study, with the aim to collect benchmark data on key performance indicators in CD surgery, to highlight areas where standards of CD surgery excel and to facilitate targeted quality improvement where indicated. Methods: All patients undergoing ileocaecal or redo ileocolic resection in the participating centres for primary and recurrent CD from June 2018 to May 2019 were included. The main objective was to collect national data on hospital volume and practice variations. Postoperative morbidity was the primary outcome. Laparoscopic surgery and stoma rate were the secondary outcomes. Results: In all, 715 patients were included: 457 primary CD and 258 recurrent CD with a postoperative morbidity of 21.6% and 34.7%, respectively. Laparoscopy was used in 83.8% of primary CD compared to 31% of recurrent CD. Twenty-five hospitals participated and the total number of patients per hospital ranged from 2 to 169. Hospitals performing more than 10 primary CD procedures per year showed a higher adoption of laparoscopy and bowel sparing surgery. Conclusions: There is significant heterogeneity in the number of CD surgeries performed per year nationally in Italy. Our data suggest that high-volume hospitals perform more complex procedures, with a higher adoption of bowel sparing surgery. The rate of laparoscopy in high-volume hospitals is higher for primary CD but not for recurrent CD compared with low-volume hospitals.
Published: 2021

20. Crohn's disease: indications for and results of strictureplasty

Author: Tonelli, F., Fazi, M., and Ficari, F.
Published: 1999
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21. Straight ileoanal anastomosis with multiple ileal myotomies as an alternative to pelvic pouch

Author: Tonelli, F., Batignani, G., Ficari, F., Mazzoni, P., Garcea, A., and Monaci, I.
Published: 1997
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22. Analysis of oxidative stress-related markers in Crohn’s disease patients at surgery and correlations with clinical findings

Author: Luceri, C., Bigagli, E., Agostiniani, Sara, Giudici, F., Zambonin, D., Scaringi, S., Ficari, F., Lodovici, M., and Malentacchi, C.
Subjects: Biomarkers, Crohn’ disease, Oxidative stress
Published: 2019

23. P188 Evaluation of Global Leadership Initiative on Malnutrition (GLIM) criteria for the diagnosis of malnutrition in patients affected by inflammatory bowel disease (IBD) candidates for elective surgery

Author: Fiorindi, C, primary, Cricchio, M, additional, Ficari, F, additional, Alpigiano, G, additional, Scaringi, S, additional, and Giudici, F, additional
Published: 2020
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24. Impact of laparoscopy on adherence to an enhanced recovery pathway and readiness for discharge in elective colorectal surgery: Results from the PeriOperative Italian Society registry

Author: Braga, M, Borghi, F, Scatizzi, M, Missana, G, Guicciardi, MA, Bona, S, Ficari, F, Maspero, M, Pecorelli, N, Pellegrino, L, Radrizzani, D, Beretta, L, Casiraghi, U, Muratore, A, Crespi, M, Iuliani, R, Bima, C, Bouzari, H, Ceretti, A, Braga, M, Borghi, F, Scatizzi, M, Missana, G, Guicciardi, M, Bona, S, Ficari, F, Maspero, M, Pecorelli, N, Pellegrino, L, Radrizzani, D, Beretta, L, Casiraghi, U, Muratore, A, Crespi, M, Iuliani, R, Bima, C, Bouzari, H, Ceretti, A, Braga, Marco, Borghi, Felice, Scatizzi, Marco, Missana, Giancarlo, Guicciardi, Marco Azzola, Bona, Stefano, Ficari, Ferdinando, Maspero, Marianna, Pecorelli, Nicolo, on behalf of PeriOperative Italian, Society, and Beretta, Luigi
Subjects: Laparoscopic surgery, Adult, Male, Registrie, medicine.medical_specialty, Enhanced recovery pathway, medicine.medical_treatment, 03 medical and health sciences, 0302 clinical medicine, Time to readiness for discharge, Colorectal surgery, Retrospective Studie, medicine, Humans, Prospective Studies, Registries, Postoperative Period, Prospective cohort study, Laparoscopy, Retrospective Studies, Aged, Postoperative Care, medicine.diagnostic_test, Elective Surgical Procedure, business.industry, Retrospective cohort study, Perioperative, Length of Stay, Middle Aged, Length of hospital stay, Conversion to Open Surgery, Patient Discharge, Surgery, Postoperative complication, Prospective Studie, Italy, Elective Surgical Procedures, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Female, Guideline Adherence, business, Abdominal surgery, Human
Abstract: Introduction: Previous studies reported that laparoscopic surgery (LPS) improved postoperative outcomes in patients undergoing colorectal surgery within an enhanced recovery program (ERP). However, the effect of minimally invasive surgery on each ERP item has not been clarified, yet. The aim of this study is to assess the impact of LPS on adherence to ERP items and recovery as measured by time to readiness for discharge (TRD). Methods: Prospectively collected data entered in an electronic Italian registry specifically designed for ERP were reviewed. Patients undergoing elective colorectal surgery were divided into three groups: successful laparoscopy, conversion to open surgery, primary open surgery. Adherence to 19 ERP elements and postoperative outcomes were compared among groups. Multivariate regression analysis was used to identify whether LPS had an independent role to improve ERP adherence and postoperative outcomes. Results: 714 patients (successful LPS 531, converted 42, open 141) underwent elective colorectal surgery within an ERP. Epidural analgesia was used in the 75.1% of open group patients versus 49.9% of LPS group patients (p = 0.012). After surgery, oral feeding recovery, i.v. fluids suspension, removal of both urinary and epidural catheters occurred earlier in the LPS group both in the overall series and in uneventful patients only. Mean TRD and length of hospital stay were significantly shorter in the LPS group (p < 0.001 for both). Overall morbidity rate was 18.7% in the LPS group versus 32.6% in the open group (p = 0.001). At multivariate analysis, LPS was significantly associated to an increased adherence to postoperative ERP items, a shorter TRD, and a reduced overall morbidity, whereas rectal surgery and new stoma formation impaired postoperative recovery. Conclusions: The present study showed that a successful laparoscopic procedure had an independent role to increase the adherence to postoperative ERP and to improve short-term postoperative outcome.
Published: 2017

25. Enhanced recovery pathways in colorectal surgery: A consensus paper by the Associazione Chirurghi Ospedalieri Italiani (ACOI) and the PeriOperative Italian Society (POIS)

Author: Ficari, F., Borghi, F., Catarci, Marco, Scatizzi, M., Alagna, V., Bachini, I., Baldazzi, G., Bardi, U., Benedetti, Marta, Beretta, Carlo Luigi, Bertocchi, E., Caliendo, D., Campagnacci, R., Cardinali, A., Carlini, M., Cascella, M., Cassini, D., Ciotti, S. -M., Cirio, A., Coata, P., Conti, Daniela, Delrio, P., Di Marco, C., Ferla, L., Fiorindi, C., Garulli, G., Genzano, C., Guercioni, G., Marra, B., Maurizi, A., Monzani, R., Pace, U., Pandolfini, L., Parisi, Carmelo Maria Antonio, Pavanello, M., Pecorelli, N., Pellegrino, Luca, Persiani, Roberto, Pirozzi, F., Pirrera, B., Rizzo, A., Rolfo, M., Romagnoli, Stella, Ruffo, G., Sciuto, A., Marini, P., Catarci M., Benedetti M., Beretta L. (ORCID:0000-0001-9924-2066), Conti D., Parisi A., Pellegrino L., Persiani R. (ORCID:0000-0002-1537-5097), Romagnoli S., Ficari, F., Borghi, F., Catarci, Marco, Scatizzi, M., Alagna, V., Bachini, I., Baldazzi, G., Bardi, U., Benedetti, Marta, Beretta, Carlo Luigi, Bertocchi, E., Caliendo, D., Campagnacci, R., Cardinali, A., Carlini, M., Cascella, M., Cassini, D., Ciotti, S. -M., Cirio, A., Coata, P., Conti, Daniela, Delrio, P., Di Marco, C., Ferla, L., Fiorindi, C., Garulli, G., Genzano, C., Guercioni, G., Marra, B., Maurizi, A., Monzani, R., Pace, U., Pandolfini, L., Parisi, Carmelo Maria Antonio, Pavanello, M., Pecorelli, N., Pellegrino, Luca, Persiani, Roberto, Pirozzi, F., Pirrera, B., Rizzo, A., Rolfo, M., Romagnoli, Stella, Ruffo, G., Sciuto, A., Marini, P., Catarci M., Benedetti M., Beretta L. (ORCID:0000-0001-9924-2066), Conti D., Parisi A., Pellegrino L., Persiani R. (ORCID:0000-0002-1537-5097), and Romagnoli S.
Abstract: Enhanced Recovery After Surgery (ERAS) pathway is a multi-di-sciplinary, patient-centered protocol relying on the implementation of the best evidence-based perioperative practice. In the field of colorectal surgery, the application of ERAS programs is associated with up to 50% reduction of morbidity rates and up to 2.5 days reduction of postoperative hospital stay. However, widespread adoption of ERAS pathways is still yet to come, mainly because of the lack of proper information and communication. Purpose of this paper is to support the diffusion of ERAS pathways through a critical review of the existing evidence by members of the two national societies dealing with ERAS pathways in Italy, the PeriOperative Italian Society (POIS) and the Associazione Italiana Chirurghi Ospedalieri (ACOI), showing the results of a consensus development conference held at Matera, Italy, during the national ACOI Congress on June 10, 2019.
Published: 2019

26. Enhanced recovery pathway in elderly patients undergoing colorectal surgery: is there an effect of increasing ages? Results from the perioperative Italian Society Registry

Author: Braga, M, Beretta, L, Pecorelli, N, Maspero, M, Casiraghi, U, Borghi, F, Pellegrino, L, Bona, S, Monzani, R, Ferrari, G, Radrizzani, D, Iuliani, R, Bima, C, Scatizzi, M, Missana, G, Guicciardi Marco, A, Muratore, A, Crespi, M, Bouzari, H, Ceretti Andrea, P, Ficari, F, Braga Marco, Beretta Luigi, Pecorelli Nicolò, Maspero Marianna, Casiraghi Umberto, Borghi Felice, Pellegrino Luca, Bona Stefano, Monzani Roberta, Ferrari Gianluigi, Radrizzani Danilo, Iuliani Riccardo, Bima Carlo, Scatizzi Marco, Missana Giancarlo, Guicciardi Marco Azzola, Muratore Andrea, Crespi Michele, Bouzari Hedayat, Ceretti Andrea Pisani, Ficari Ferdinando, Braga, M, Beretta, L, Pecorelli, N, Maspero, M, Casiraghi, U, Borghi, F, Pellegrino, L, Bona, S, Monzani, R, Ferrari, G, Radrizzani, D, Iuliani, R, Bima, C, Scatizzi, M, Missana, G, Guicciardi Marco, A, Muratore, A, Crespi, M, Bouzari, H, Ceretti Andrea, P, Ficari, F, Braga Marco, Beretta Luigi, Pecorelli Nicolò, Maspero Marianna, Casiraghi Umberto, Borghi Felice, Pellegrino Luca, Bona Stefano, Monzani Roberta, Ferrari Gianluigi, Radrizzani Danilo, Iuliani Riccardo, Bima Carlo, Scatizzi Marco, Missana Giancarlo, Guicciardi Marco Azzola, Muratore Andrea, Crespi Michele, Bouzari Hedayat, Ceretti Andrea Pisani, and Ficari Ferdinando
Abstract: Previous studies reported that enhanced recovery pathway (ERP) is safe in elderly who did not require a specifically tailored protocol. In previous studies, elderly have been considered as a homogeneous cohort and the cut-off value to identify them was different. The aim of the present study is to assess the compliance to ERP and its impact on postoperative outcome in three subgroups of elderly patients with increasing ages. Prospectively collected data entered in an electronic Italian registry specifically designed for ERP were reviewed. 315 elderly patients undergoing elective colorectal resection were divided into three groups. Group 1: 71–75 years (n = 105), Group 2: 76–80 years (n = 117), Group 3: over 80 years (n = 93). Primary endpoints of the study were adherence to ERP and time to readiness for discharge (TRD). Compliance to ERP was similar in the three groups. No difference among groups was found for mortality, overall morbidity, major complications, reoperation rate and readmission rate. Median TRD and length of hospital stay (LOS) were progressively longer with increasing age (p = 0.018 and p = 0.078, respectively). Increasing age did not impact on adherence to ERP and postoperative morbidity, but delayed both TRD and LOS.
Published: 2018

27. Identification of core items in the enhanced recovery pathway

Author: Braga, M, Scatizzi, M, Borghi, F, Missana, G, Radrizzani, D, Gemma, M, Beretta, L, Bona, S, Monzani, R, Azzola, M, Muratore, A, Crespi, M, Iuliani, R, Bima, C, Bouzari, H, Ceretti, A, Pellegrino, L, Maspero, M, Pecorelli, N, Casiraghi, U, Ficari, F, Braga, Marco, Scatizzi, Marco, Borghi, Felice, Missana, Giancarlo, Radrizzani, Danilo, Gemma, Marco, Beretta, Luigi, Bona, Stefano, Monzani, Roberta, Azzola, Marco, Muratore, Andrea, Crespi, Michele, Iuliani, Riccardo, Bima, Carlo, Bouzari, Hedayat, Ceretti, Andrea Pisani, Pellegrino, Luca, Maspero, Marianna, Pecorelli, Nicolò, Casiraghi, Umberto, Ficari, Ferdinando, Braga, M, Scatizzi, M, Borghi, F, Missana, G, Radrizzani, D, Gemma, M, Beretta, L, Bona, S, Monzani, R, Azzola, M, Muratore, A, Crespi, M, Iuliani, R, Bima, C, Bouzari, H, Ceretti, A, Pellegrino, L, Maspero, M, Pecorelli, N, Casiraghi, U, Ficari, F, Braga, Marco, Scatizzi, Marco, Borghi, Felice, Missana, Giancarlo, Radrizzani, Danilo, Gemma, Marco, Beretta, Luigi, Bona, Stefano, Monzani, Roberta, Azzola, Marco, Muratore, Andrea, Crespi, Michele, Iuliani, Riccardo, Bima, Carlo, Bouzari, Hedayat, Ceretti, Andrea Pisani, Pellegrino, Luca, Maspero, Marianna, Pecorelli, Nicolò, Casiraghi, Umberto, and Ficari, Ferdinando
Abstract: Background & aims: The Enhanced Recovery After Surgery (ERAS) pathway represents an optimal approach in patients undergoing colorectal surgery but complexity in implementing its items could limit its application. The aim of this study is to identify possible core items within an ERAS pathway following elective colorectal resection. Methods: This is a retrospective review of data prospectively collected between January 2014 and September 2015 by 14 Italian Hospitals in an electronic registry dedicated to an ERAS protocol. 722 patients undergoing elective colorectal surgery within an ERAS protocol have been included in the study. Adherence to ERAS items was assessed in all patients. A secondary analysis was restricted to pre- and intraoperative ERAS items. Time to readiness for discharge (TRD) was the primary endpoint of the study. Postoperative overall morbidity was the secondary endpoint. Results: Multivariate analyses showed that active intraoperative warming (p = 0.008), early stop of intravenous fluids (p = 0.0001), and early removal of urinary catheter (p = 0.0001) were associated to a shorter TRD, while early stop of intravenous fluids (p < 0.001) also reduced morbidity. When the analysis was restricted to pre- and intraoperative items, removal of NGT at the end of surgery had an independent role to shorten TRD (p < 0.001) and to reduce overall morbidity (p = 0.019), while the absence of oral bowel preparation reduced postoperative overall morbidity (p = 0.021). Conclusions: In implementing an ERAS pathway, hospitals could initially focus on active intraoperative warming, early stop of intravenous fluids, early removal of urinary catheter, removal of NGT at the end of surgery, and absence of oral bowel preparation, keeping on continuous effort to apply the complete ERAS protocol.
Published: 2018

28. P657 Postoperative outcome in Crohn’s disease: Observational study of 1283 surgical patients

Author: Zambonin, D, primary, Lavorini, E, additional, Giudici, F, additional, Ficari, F, additional, Bagnoli, S, additional, and Scaringi, S, additional
Published: 2018
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29. P599 Short- and long-term outcome of minimally invasive approach for Crohn’s disease: Comparison between single incision, robotic-assisted and conventional laparoscopy

Author: Zambonin, D, primary, Giudici, F, additional, Ficari, F, additional, Rogai, F, additional, and Scaringi, S, additional
Published: 2018
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30. Impatto economico dell’immunonutrizione nei pazienti chirurgici oncologici

Author: D'Angela, D, De Luca, R, Ficari, F, Gasbarrini, A, Marrocco, W, Montorsi, M, and Spandonaro, F
Subjects: Settore SECS-P/06 - Economia Applicata
Published: 2016

31. Enhanced Recovery Program in High-Risk Patients Undergoing Colorectal Surgery: Results from the PeriOperative Italian Society Registry

Author: Braga, M, Pecorelli, N, Scatizzi, M, Borghi, F, Missana, G, Radrizzani, D, Azzola, M, Beretta, L, Bima, C, Bona, S, Bouzari, H, Casiraghi, U, Ceretti, A, Crespi, M, Ficari, F, Iuliani, R, Maspero, M, Monzani, R, Muratore, A, Pellegrino, L, Braga, Marco, Pecorelli, Nicolò, Scatizzi, Marco, Borghi, Felice, Missana, Giancarlo, Radrizzani, Danilo, Azzola, Marco, Beretta, Luigi, Bima, Carlo, Bona, Stefano, Bouzari, Hedayat, Casiraghi, Umberto, Ceretti, Andrea Pisani, Crespi, Michele, Ficari, Ferdinando, Iuliani, Riccardo, Maspero, Marianna, Monzani, Roberta, Muratore, Andrea, Pellegrino, Luca, Braga, M, Pecorelli, N, Scatizzi, M, Borghi, F, Missana, G, Radrizzani, D, Azzola, M, Beretta, L, Bima, C, Bona, S, Bouzari, H, Casiraghi, U, Ceretti, A, Crespi, M, Ficari, F, Iuliani, R, Maspero, M, Monzani, R, Muratore, A, Pellegrino, L, Braga, Marco, Pecorelli, Nicolò, Scatizzi, Marco, Borghi, Felice, Missana, Giancarlo, Radrizzani, Danilo, Azzola, Marco, Beretta, Luigi, Bima, Carlo, Bona, Stefano, Bouzari, Hedayat, Casiraghi, Umberto, Ceretti, Andrea Pisani, Crespi, Michele, Ficari, Ferdinando, Iuliani, Riccardo, Maspero, Marianna, Monzani, Roberta, Muratore, Andrea, and Pellegrino, Luca
Abstract: Background: Enhanced recovery after surgery (ERAS) pathways represent the optimal approach for patients undergoing colorectal surgery. Elderly or low physical status patients have been often excluded from ERAS pathways because considered at high risk. The aim of this study is to assess the adherence to ERAS protocol and its impact on short-term postoperative outcome in patients with different surgical risk undergoing elective colorectal resection. Methods: Prospectively collected data entered in an electronic Italian registry specifically designed for ERAS were reviewed. Patients were divided into four groups according to age (70-year-old cutoff) and preoperative physical status as measured by the ASA grade (I–II vs. III–IV). Adherence to 18 ERAS elements and postoperative outcomes were compared between groups. Regression analysis was used to identify independent factors associated with improved outcomes. Results: Eleven Italian hospitals reported data on 706 patients undergoing elective colorectal surgery within an ERAS protocol. Patients with low physical status had reduced adherence to preoperative carbohydrate loading, epidural analgesia, PONV prophylaxis, and early urinary catheter removal. No difference was found between groups for adherence to other perioperative elements. Major complications occurred in 37 (5.2 %) patients without significant differences among groups (p = 0.384). Median (IQR) time to readiness for discharge (TRD) was 4 (3–6) days, length of hospital stay (LOS) was 6 (4–7) days, and both were significantly shorter by only 1 day in the groups of younger patients (p < 0.001). At multivariate analysis, laparoscopy increased adherence to ERAS items and reduced TRD, LOS, and morbidity. A high ASA grade was significantly associated with lower adherence, whereas older age significantly prolonged TRD and LOS. Conclusion: ERAS pathway can be safely applied in elderly and low physical status patients yielding slight differences in postoperative morbidi
Published: 2017

32. Glutamitaly 2003: SINPE Consensus Paper on the use of glutamine in adult artificial nutrition [GLUTAMITALY 2003: Consensus Paper SINPE sull'impiego della glutamina nella nutrizione artificiale dell'adulto]

Author: Braga, M., Muscaritoli, M., Pittiruti, M., Biffi, R., Biolo, G., Bobbio Pallavicini, F., Bossola, M., Bozzetti, F., Candusso, M., Carideo, P., Contaldo, F., Cozzaglio, L., Degaudio, A. R., Ficari, F., Gallitelli, L., Gavazzi, C., Giacosa, A., Gianotti, L., Guglielmi, F. W., Laviano, A., Paccagnella, A., Palmo, A., LORIS PIRONI, Radrizzani, D., Salis, C., Sukkar, S. G., Uderzo, C., Vannucci, A., Zanello, M., Braga, M., Muscaritoli, M., Pittiruti, M., Biffi, R., Biolo, Gianni, Bobbio Pallavicini, F., Bossola, M., Bozzetti, F., Candusso, M., Carideo, P., Contaldo, F., Cozzaglio, L., Degaudio, A. R., Ficari, F., Gallitelli, L., Gavazzi, C., Giacosa, A., Gianotti, L., Guglielmi, F. W., Laviano, A., Paccagnella, A., Palmo, A., Pironi, L., Radrizzani, D., Salis, C., Sukkar, S. G., Uderzo, C., Vannucci, A., and Zanello, M.
Subjects: SINPE Consensus, glutamine, artificial nutrition, SINPE Consensu
Published: 2004

33. The role of cytoreductive surgery alone for the treatment of peritoneal carcinomatosis of colorectal origin. A retrospective analysis with regard to multimodal treatments

Author: Scaringi, S, Leo, F, Canonico, G, Batignani, G, Ficari, F, and Tonelli, F.
Published: 2009

34. Analisi retrospettiva sulla mortalità e la morbilità della chirurgia citoriduttiva nel trattamento curativo delle carcinosi peritoneali di origine colorettale

Author: Canonico, G., Scaringi, S., Leo, F., Ficari, F., BATIGNANI, GIACOMO, and TONELLI, FRANCESCO
Subjects: peritoneal carcinomatosis, colorectal tumor, cytoreduction
Published: 2008

35. Treatment of perianal fistulas in Crohn's disease by local injection of antibody to TNF-alpha accounts for a favourable clinical response in selected cases: a pilot study

Author: Asteria, Cr, Ficari, F, Bagnoli, S, Milla, M, and Tonelli, F.
Published: 2006

36. Mutations at coding repeats in the progression of colorectal carcinomas with microsatellite mutator phenotype

Author: Palmirotta, R, El Zohbi, B, Matera, S, Vanni, C, Curia, Mc, Aceto, G, Catalano, Teresa, Veschi, S, Leone, B, Messerini, L, Valanzano, R, Ficari, F, Stigliano, V, Tonelli, F, Casale, V, Guadagni, F, Battista, P, Mariani Costantini, R, and Cama, A.
Published: 2001

37. mlh1 and msh2 transcript and genetic heterogeneity in hereditary nonpolyposis colorectal cancer

Author: Curia, Mc, Palmirotta, R, Aceto, G, Catalano, Teresa, El Zohbi, B, Matera, S, Di Tizio, M, Messerini, L, Valanzano, R, Ficari, F, Stigliano, V, Tonelli, F, Casale, V, Guadagni, F, Mariani Costantini, R, Battista, P, and Cama, A.
Published: 2001

38. La disciplina degli enti non profit

Author: Marasa', G, Di Cecco, G, Balzano, M, Tabet, G, Bises, B, Ficari, F, Rossi, P, Sciuto, M, Cardinale, E, and Iocca, M
Subjects: Settore IUS/04 - Diritto Commerciale
Published: 1998

39. P072 TEN YEARS EXPERIENCE WITH SIDE TO SIDE ISOPERISTALTIC STRICTUREPLASTY (SSIS) IN SMALL BOWEL CROHN'S DISEASE

Author: Tonelli, F., primary, Fazi, M., additional, Ficari, F., additional, Canonico, G., additional, and Giudici, F., additional
Published: 2007
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40. ErbB related growth factor receptors and TGF alpha in the neoplastic progression of colorectal epithelium

Author: Muraro, R, Ficari, F, Alimandi, Maurizio, Visco, V, Valli, C, Curia, Mc, French, D, Grilli, A, Caramia, F, Tonelli, F, and AND MARIANI COSTANTINI, R.
Published: 1991

41. Regional Heterogeneity and complementation in the expression of the tumor-associated glycoprotein-72 epitopes in colorectal-cancer

Author: Muraro, R, Frati, Luigi, Bei, R, Ficari, F, Valli, C, French, Deborah, Mammarella, S, Caramia, Francesca, Fegiz, G, and MARIANI COSTANTINI, R.
Published: 1991

42. Genomic alterations in adenomas and carcinomas from an Italian sample of familial adenomatous polyposis patients

Author: Alimandi, Maurizio, Ficari, F, Pontecorvi, A, Muraro, R, French, D, Battista, P, Mammarella, S, Tonelli, F, and Frati, L. AND MARIANI COSTANTINI R.
Published: 1991

43. Amoxicillin/Clavulanic Acid Versus Cefotaxime for Antimicrobial Prophylaxis in Abdominal Surgery: A Randomized Trial

Author: Tonelli, F., primary, Mazzei, T., additional, Novelli, A., additional, Mazzoni, P., additional, Ficari, F., additional, and Group, The Italian Cooperative, additional
Published: 2002
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44. Crohn's disease: indications for and results of strictureplasty

Author: Tonelli, F., primary, Fazi, M., additional, and Ficari, F., additional
Published: 2000
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45. APC gene mutations and colorectal adenomatosis in familial adenomatous polyposis

Author: Ficari, F, primary, Cama, A, additional, Valanzano, R, additional, Curia, M C, additional, Palmirotta, R, additional, Aceto, G, additional, Esposito, D L, additional, Crognale, S, additional, Lombardi, A, additional, Messerini, L, additional, Mariani-Costantini, R, additional, Tonelli, F, additional, and Battista, P, additional
Published: 2000
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46. Adjuvant postoperative radiotherapy in rectal cancer: 148 cases treated at Florence University with 8 years median follow-up

Author: Cionini, L., primary, Marzano, S., additional, Boffi, L., additional, Cardona, G., additional, Ficari, F., additional, Fucini, C., additional, and Tonelli, F., additional
Published: 1996
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47. INTEGRIN BETA-4 EXPRESSION IN COLORECTAL-CANCER

Author: FALCIONI, R, primary, TURCHI, V, additional, VITULLO, P, additional, NAVARRA, G, additional, FICARI, F, additional, CAVALIERE, F, additional, SACCHI, A, additional, and MARIANICOSTANTINI, R, additional
Published: 1994
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48. Penetration of cefotetan into suction skin blister fluid and tissue homogenates in patients undergoing abdominal surgery

Author: Mazzei, T, primary, Tonelli, F, additional, Novelli, A, additional, Ficari, F, additional, Mazzoni, C, additional, Anastasi, A, additional, and Periti, P, additional
Published: 1994
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49. Antimicrobial Chemoimmunoprophylaxis in Colorectal Surgery with Cefotetan and Thymostimulin: Prospective, Controlled Multicenter Study

Author: Periti, P., primary, Tonelli, F., additional, Mazzei, T., additional, and Ficari, F., additional
Published: 1993
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50. Tissue Distribution of Cefotetan in Patients with Crohn’s Disease

Author: Mazzei, T., primary, Tonelli, F., additional, Anastasi, A., additional, Ficari, F., additional, Novelli, A., additional, and Periti, P., additional
Published: 1991
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