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Byline: Yi-Ju Chen (1), Chih-Sung Hsieh (2), Hock-Liew Eng (1), Chao-Cheng Huang (1) Keywords: Ovarian fibroma; Ovarian tumour; Infancy; Gorlin's syndrome Abstract: Ovarian fibroma rarely occurs in prepubertal girls. We report an ovarian fibroma in a 7-month-old female infant presenting as a right abdominal mass. The tumour was composed of oval-to-spindle cells forming interlacing fascicles and intermingling with collagen fibres. Immunohistochemically, the tumour cells were weakly positive for estrogen receptor and progesterone receptor but negative for inhibin. To the best of our knowledge, this is the youngest case of ovarian fibroma up-to-date in the English literature. Because Gorlin's syndrome was not present in the patient's family, other factors such as germline or somatic mutations may predispose the occurrence of this ovarian fibroma in infancy. Author Affiliation: (1) Department of Pathology, Chang Gung Memorial Hospital, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung , County 833, Taiwan (2) Department of Pediatric Surgery, Chang Gung Memorial Hospital, Kaohsiung, Taiwan Article History: Registration Date: 13/08/2004 Accepted Date: 25/07/2003 Online Date: 30/09/2004

Code Number: cn02002 ABSTRACT Cytological parameters were studied in 18 fibroepithelial tumours of the breast including 8 benign phyllodes, 1 malignant phyllodes, and 9 fibroadenomas between 1999 to 2001. Cytology [...]

Byline: Mandeep. Dhingra, Sangeeta. Amladi, Shankar. Savant, Chitra. Nayak We describe here a three year-old girl with classic clinical and histological features of juvenile hyaline fibromatosis. We found a history [...]

Byline: V. Patel, V. Kharkar, U. Khopkar A 63-year-old male presented with an asymptomatic, slow-growing swelling on the right lower limb for the past one and half years. The histopathology [...]

A 15-year-old white boy was referred to the oral and maxillofacial surgeon for evaluation of a large, rapidly growing expansile lesion in the left posterior mandible. According to the patient, [...]

A case is presented of a baby who developed myofibromatosis one month after birth. Infantile myofibromatosis is a disorder characterized by fibrous tumors in the skin, muscle, bone, and/or gastrointestinal tract. It is the most common fibrous tumor of infancy. If the gastrointestinal tract is not affected, the child will have an excellent prognosis. The tumors may regress spontaneously within 1 to 2 years. Children with involvement of the gastrointestinal tract have a more serious prognosis because the tumors can obstruct organs and prevent them from functioning properly., Background. Infantile myofibromatosis is marked by the development of firm, discrete, flesh-colored to purple nodules in skin, muscle, bone, and/or subcutaneous tissues. In cases without visceral involvement, the prognosis is excellent with expected spontaneous regression of nodules in 1 to 2 years. Visceral lesions are associated with significant morbidity and mortality generally within the first few months of life secondary to obstruction of a vital organ, failure to thrive, or infection. Observation. We present a case of congenital myofibromatosis initially presenting as a single, asymptomatic nodule on the midback of an otherwise healthy 1-month-old white boy. Over the subsequent 6 months, the child developed a left-sided head tilt with the formation of additional myofibromas of the skin and musculature, but without visceral involvement. Physical examinations have continued to show age-appropriate growth and development. Conclusion. Clinicians should be aware of this rare but potentially life-threatening entity and consider infantile myofibromatosis in the differential diagnosis of pediatric dermal and subcutaneous nodules, particularly when associated with a new onset of head tilt. Close clinical follow-up is recommended in all cases of infantile myofibromatosis. Pediatrics 1999;104:113-115; infantile myofibromatosis, leiomyoma, head tilt., Infantile myofibromatosis is a mesenchymal disorder characterized by the proliferation of fibrous tumors in the skin, muscle, bone, and/or viscera, and is the most common fibrous tumor of infancy. Solitary [...]