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Multiple closely associated fibroepithelial polyps, also known as acrochordonous plaques, are benign proliferative lesions, described so far only on the dorsal neck and the head of bulldogs and pugs, and on the lumbo‐sacral region of a dobermann. Here, we report for the first time the presence of multiple closely associated fibroepithelial polyps in the external ear canal of three French bulldogs with chronic otitis. In all the cases, lesions presented as a plaque composed of domed shaped, villous or filiform proliferations. The diagnosis was obtained combining video‐otoscopic and histopathological findings. In only one case, these lesions were considered critical for the persistence of the otitis externa, and surgical treatment was recommended. Multiple closely associated fibroepithelial polyps should be set among the differential diagnoses of plaque‐like lesions with an irregular surface in the external ear canal of French bulldogs. [ABSTRACT FROM AUTHOR]

Aim: To analyze the different types of benign vulvar tumors that required surgery and to correlate with the histopathological findings postoperatively. Materials and methods: This retrospective study was conducted over a period of 1 year in a tertiary care hospital in Southern India. A total of 11 benign solid vulvar masses which were operated between July 2022 and June 2023 were included in the study. Demographic data, description of the mass, time taken to seek medical attention, surgical procedure and pictographic histopathological findings were studied. Results: The study population ranges from 26 to 45 years with a mean age of 35.8 ± 7.33 years. The mean time taken to seek medical care for the detected mass was 16.25 ± 17.23 months. The earliest presentation was noted 6 months after detection, while one patient presented 6 years after the appearance of the mass. The largest mass was 12 x 15 cm in size. All the masses underwent complete surgical excision with no postoperative complications. The most common pathological finding was fibroepithelial polyp, noted in four patients, followed by leiomyoma of the vulva and vulvar hemangioma. The other masses were reported as vulvar endocervicosis, epidermoid cyst, and lipoma, respectively. It is important to note that these tumors, though benign, can cause functional, sexual, and emotional impairment. These women were followed up 6 months postoperatively and did not show any recurrence. The quality of life assessment using the VR-12 validated scale indicated the improvement in all 11 women after surgery. Conclusion: Surgical excision of benign vulvar masses not only mitigates the risk of premalignant tumors of the vulva, but also greatly improves the quality of life. Clinical significance: • This study helps us understand benign vulvar masses and the importance of surgical removal of these masses to prevent risk of malignancy. • Surgical excision helps to greatly improve the quality of life in these women. [ABSTRACT FROM AUTHOR]

Fibroepithelial polyps are rare benign tumors originating from the mesoderm and are more commonly found in the renal pelvis and distal ureter and less frequently in the proximal ureter or bladder. This case report presents a fibroepithelial polyp occurring in the bladder of the fetus, showcasing its two-dimensional ultrasound, three-dimensional ultrasound, color Doppler, and spectral Doppler ultrasound findings, providing a reference for the accurate diagnosis of this condition.

Fibroepithelial polyps of the anus (FEPA) are a common benign polypoid proliferation of the stroma covered by squamous epithelium. They are also an often-overlooked part of pathological practice. Currently, immunohistochemistry (IHC) for p16 is the only recommended test for anal intraepithelial neoplasia, but the expression of p16 in stromal multinucleated atypical cells in FEPA has not been described. We aimed to evaluate the expression of p16 in stromal multinucleated atypical cells in FEPA and its role as a diagnostic biomarker to determine the origin of the atypical multinucleated cells in the stroma of FEPA and to rule out the possibility of a neoplastic process. Therefore, we researched a series of 15 FEPA in middle-aged patients histologically and by IHC. Examination of the subepithelial connective tissue from the FEPA showed bizarre, multinucleated cells, while their causal relationship with human papillomavirus (HPV) infection was rejected. In all cases, these cells showed mild to moderate atypical nuclear features and positive expression for p16, while the overlying squamous epithelium was negative. We concluded that FEPA are benign lesions in the stroma where mononuclear and multinucleated (sometimes atypical) cells showing fibroblastic and myofibroblastic differentiation can be found. Nevertheless, we believe that these cells have a practical diagnostic significance, although sometimes the presence of giant cells is difficult to establish, especially in the inflammatory context. The histological similarity between FEPA and normal anal mucosa supports the hypothesis that FEPA may represent the reactive hyperplasia of subepithelial fibrous connective tissue of the anal mucosa.

Fibroepithelial polyps of the anus (FEPA) are a common benign polypoid proliferation of the stroma covered by squamous epithelium. They are also an often-overlooked part of pathological practice. Currently, immunohistochemistry (IHC) for p16 is the only recommended test for anal intraepithelial neoplasia, but the expression of p16 in stromal multinucleated atypical cells in FEPA has not been described. We aimed to evaluate the expression of p16 in stromal multinucleated atypical cells in FEPA and its role as a diagnostic biomarker to determine the origin of the atypical multinucleated cells in the stroma of FEPA and to rule out the possibility of a neoplastic process. Therefore, we researched a series of 15 FEPA in middle-aged patients histologically and by IHC. Examination of the subepithelial connective tissue from the FEPA showed bizarre, multinucleated cells, while their causal relationship with human papillomavirus (HPV) infection was rejected. In all cases, these cells showed mild to moderate atypical nuclear features and positive expression for p16, while the overlying squamous epithelium was negative. We concluded that FEPA are benign lesions in the stroma where mononuclear and multinucleated (sometimes atypical) cells showing fibroblastic and myofibroblastic differentiation can be found. Nevertheless, we believe that these cells have a practical diagnostic significance, although sometimes the presence of giant cells is difficult to establish, especially in the inflammatory context. The histological similarity between FEPA and normal anal mucosa supports the hypothesis that FEPA may represent the reactive hyperplasia of subepithelial fibrous connective tissue of the anal mucosa. [ABSTRACT FROM AUTHOR]

Bronchial fibroepithelial polyps are exceedingly rare with few cases have been reported. They can manifest with a wide array of symptoms; ranging from being totally asymptomatic, cough, refractory dyspnea, and hemoptysis. In our case, our patient's condition was diagnosed and was managed as asthma. It is one of the rare benign conditions to be encountered, shares similar morphology with other tumors such as angiomyofibroblastoma, aggressive angiomyxoma, and cellular angiofibroma. These lesions have a slow growth pattern which may end up with obstruction. According to the tumor size and symptoms caused by it, treatment varies from observation to complete resection. This case describes an incidental finding of fibroepithelial polyp in the main bronchus for a patient with long-term refractory cough for 5 years, was misdiagnosed to have asthma. Diagnosis typically involves imaging and bronchoscopy, followed by appropriate therapeutic measures and careful monitoring to assess the prognosis. [ABSTRACT FROM AUTHOR]

Fibroepithelial polyps (FEP) are rare benign tumors urinary collecting system. Diagnosis is suspected on Computed Tomography (CT) and confirmed via histopathology. Treatment options vary from historic nephroureterectomy to more contemporary methods of ablation. Authors present a case of a symptomatic FEP causing left-sided hydronephrosis and episodic flank pain treated by a urologic surgeon. The patient underwent robotic pyeloplasty and excision of the tumors, yielding preserved renal function and resolution of the hydronephrosis.

Abstract Endotracheal fibroepithelial polyp is a rare disease in the airways. This report describes a rare case of a tracheal giant fibroepithelial polyp. A 17-year-old woman was admitted to the hospital with severe acute respiratory failure. Chest computed tomography revealed a tumor located below the epiglottis. Endotracheal bronchoscopic examination showed a giant polyp. This endotracheal polyp was removed with ablation, by using high-frequency electricity through flexible bronchoscopy under intravenous anesthesia. The patient has had a good recovery after the intervention and at long-term follow-up. We herein describe and discuss the appropriate therapeutic approach and also review the pertinent literature.

Endotracheal fibroepithelial polyp is a rare disease in the airways. This report describes a rare case of a tracheal giant fibroepithelial polyp. A 17-year-old woman was admitted to the hospital with severe acute respiratory failure. Chest computed tomography revealed a tumor located below the epiglottis. Endotracheal bronchoscopic examination showed a giant polyp. This endotracheal polyp was removed with ablation, by using high-frequency electricity through flexible bronchoscopy under intravenous anesthesia. The patient has had a good recovery after the intervention and at long-term follow-up. We herein describe and discuss the appropriate therapeutic approach and also review the pertinent literature. [ABSTRACT FROM AUTHOR]

Fibroepithelial polyp (FEP) is a common benign tumor occurring in the skin and genitourinary tract, and there are no reports of multiple FEPs occurring on the myocutaneous flap. We report two cases of FEPs occurring diffusely on the skin tissue of the free anterolateral thigh flap after surgical reconstruction for oral squamous cell carcinoma. Clinically, multiple papillary nodules on the myocutaneous flap gradually increased. CT and MRI showed multiple papillary nodules on an enhanced layer covering the entire myocutaneous flap. PET/CT showed high uptake. One case was diagnosed with FEPs by surgery, the other by biopsy. The tumor-limited localization on the myocutaneous flap, characteristic morphology showing multiple papillary projection with an enhanced layer, and MRI signal showing patchy mild elevation of the apparent diffusion coefficient value may help in differential diagnosis from tumor recurrence or secondary carcinoma of the myocutaneous flap on diagnostic imaging. [ABSTRACT FROM AUTHOR]

Aim: To highlight the uncommon manifestation of acrochordon in a postmenopausal woman. Background: Acrochordons are benign mesenchymal neoplasms. They are frequently noted in women of reproductive age group. Their occurrence in postmenopausal women is rare. Case description: A 56-year-old multiparous postmenopausal woman presented with a large vulval acrochordon of size 8 cm x 7.5 cm x 7.5 cm. Total surgical excision was performed under regional anesthesia and its diagnosis was confirmed on histopathology. Conclusion: Vulvar acrochordons are uncommon. Their occurrence in a postmenopausal age group is rare. Complete surgical excision is the cure. Clinical significance: Their clinical features mimic malignancy hence histopathology is important for definitive diagnosis. Ultrasonography aids in the initial diagnosis of the lesion. [ABSTRACT FROM AUTHOR]

Oral fibroepithelial polyps (FEPs) are common, benign, nonneoplastic lesions in humans that often develop slowly in sites of local irritation or trauma. This study analyzed 23 oral fibroepithelial polypoid lesions retrieved from 21 dogs (2014–2021). All lesions were pedunculated with usually an irregular/cauliflower-like or rarely smooth surface. FEPs most commonly arose under or lateral to the tongue; other sites included the labial and gingival mucosa, soft palate, and hard palate. All the lesions were characterized by a thick fibrovascular stalk consisting of bundles of fibrocytes and fibroblasts embedded in a collagenous matrix rich in blood vessels. The surface squamous epithelium, when evaluable, was hyperplastic (22/22; 100%) with frequent parakeratotic hyperkeratosis (12/22; 54.5%). Ulceration of variable extent was observed in 13/23 cases (56.5%). Inflammation was associated with 18/23 cases (78.3%), and was mostly lymphoplasmacytic. The connective tissue was consistently immunoreactive for vimentin and generally negative for smooth muscle actin and desmin. All FEPs in cases with available clinical outcome data did not recur after surgical excision. The presence of chronic inflammation and ulceration suggests a causative role of chronic irritation in the pathogenesis of canine oral FEPs. FEPs should be included among the differential diagnoses of proliferative lesions of the oral cavity in dogs. [ABSTRACT FROM AUTHOR]

Post-intervention complications after transvenous cardiac procedures are mostly related to venous structures and heart chambers. Cutaneous and subcutaneous complications are usually ignored. However, these complications can lead to devastating conditions such as extreme bleeding, infection, and ecchymosis, etc. The development of a fibroepithelial polyps following transvenous pacemaker insertion is very rare. The vascularity of this lesion necessitates prompt diagnosis and treatment to avoid unwanted outcomes. Here, we report an interesting case of a traumatized fibroepithelial polyp with hemorrhage as a complication of central line insertion for transvenous transient pacemaker lead in a 60-year male patient. [ABSTRACT FROM AUTHOR]

In this rare case we report a 3-week-old boy with postnatal continues stomach pains, crying and severe dysuria, caused by bladder outlet obstruction due to a histopathological confirmed fibroepithelial polyp in the prostatic urethra. The condition was diagnosed and fully treated with ultrasound and a therapeutic cystoscopy.

Polyps are exophytic or sessile lesions growing from the mucosal surface. They are usually idiopathic. They may be neoplastic or nonneoplastic.1 They have been reported to arise in the ear canal, cervix, colorectal area, nose, uterus, stomach, throat, vulva, bronchus and urinary bladder.4 Punctal polyps have never been reported in the literature before. A thirty-year-old male patient presented to the oculoplastic clinic with the complaint of small polypoidal masses present in the medial corners of both eyes. They had been there for the last 3 months and were associated with itching and foreign body sensations. There was no systemic history of any allergy or use of any anti-allergic drugs. An excisional biopsy of these lesions was done and sent for histopathology. They were found to be polypoidal fragments of tissue covered by stratified squamous epithelium. The stroma was fibrous and showed mild chronic non-specific inflammation composed of lymphocytes and few plasma cells. Few blood vessels were seen. These were labelled as fibroepithelial punctal polyps. This is a rare location of presentation of polyp and hasn’t been reported before. It is important to distinguish it from papilloma and bear the possibility of a polyp in mind to avoid unnecessary medical management. [ABSTRACT FROM AUTHOR]

Abstract Background Fibroepithelial polyps located in the ureter constitute 2–6% of all benign tumors in the urinary system. Distinguishing these lesions from transitional cell carcinoma is essential to avoid unnecessary nephroureterectomy. Case presentation A 59-year-old asymptomatic caucasian male patient was enrolled in follow-up for Ta low-grade transitional cell bladder cancer 4 years ago in our clinic. A suspicious, solid, contrast-enhancing mass 15 × 9 mm in diameter in the anteromedial mid-section of the left kidney, which was causing minimal washout and largely located in the parenchyma, was reported as renal cell carcinoma on computed tomography during routine controls. In the excretory phase, soft-tissue densities of approximately 30 mm in length, which were located in the distal part of the left ureter at a distance of 40 mm from the ureterovesical junction, extending towards the lumen suggested a urethral carcinoma. Urothelial lesion was reported as fibroepithelial polyp after histopathological examination. Partial nephrectomy for the mass, which was reported as renal cell carcinoma in the left kidney, was performed in the first postoperative month. Histopathological examination revealed Fuhrman grade 1 papillary type renal cell carcinoma. No recurrence was observed in the first year after treatment. Conclusions Although our patient had a bladder transitional cell carcinoma and a suspicious renal cell carcinoma mass of 15 mm in the ipsilateral kidney, the patient was safeguarded from unnecessary nephroureterectomy early on by cross-sectional and endoscopic imaging of the ureter.

Background: Fibroepithelial polyps are benign tumors located in the upper ureter and ureteropelvic junction. Given their location in rare cases they can cause hydronephrosis. Clinically and radiologically, it is difficult to distinguish them from ureteropelvic junction obstruction. Case report: A 6-years boy was admitted with intermittent left flank pain. An ultrasound revealed a III degree hydronephrosis, confirmed by an MR examination which highlighted an obstruction at the level of the middle tract of the ureter. We performed a robotic intervention. During surgery the presence of ureteral polyp was evident as the cause of the obstruction. An end-to-end uretero-ureteral anastomosis was performed. Conclusion: Ureteral polyps were mainly reported in adults, but recently several series revealed higher incidence among pediatric patients. Diagnosis of ureteral polyps is challenging, but even without a definite diagnosis, the best strategy is that of a robotic approach similar to that of the pathologies of the ureteropelvic junction.

DICER1, a member of the ribonuclease III family, is involved in the biogenesis of microRNAs and, hence, it influences gene expression regulation. DICER1 germline (associated with the inherited DICER1 syndrome) or somatic mutations have been linked to tumorigenesis in histogenetically diverse benign and malignant neoplasms in different organs including pleuropulmonary blastoma, cystic nephroma, embryonal rhabdomyosarcoma, nasal chondromesenchymal hamartoma, poorly differentiated thyroid carcinoma, thyroblastoma, intracranial sarcoma and gonadal Sertoli-Leydig cell tumors in addition to others. Moreover, rare botryoid (giant) fibroepithelial polyps may harbor this mutation. Herein, we describe the first reported case of a DICER1-mutated botryoid fibroepithelial polyp occurring within the parotid duct of a 65-year-old female who has no other features or family history of the DICER1 syndrome. Based on its distinctive morphology, we tested this lesion specifically for DICER1 mutations and confirmed the presence of a pathogenic DICER1 variant with a low allele frequency, consistent with a somatic mutation. [ABSTRACT FROM AUTHOR]

We present a young adult male patient with suspicious lesion in urinary bladder found on routine exam using ultrasound. Urethrocystoscopy was performed and revealed urethral fibroepithelial polyp that was causing partial and total obstruction of urine flow. We have documented this case with a series of high-quality endoscopic images.

Background/Aim: Benign skin tumors are soft-tissue lesions that present with poor cosmesis along with pain, functional limitations, deformity, and hypoesthesia. Rapid progression and giant forms should be evaluated and differentiated from malignant transformation. The aim of this study is to evaluate the patients operated for giant benign skin tumors and to assess clinical experience about indications, size, location, and histopathological results and follow-up period. Materials and Methods: The present study included 16 consecutive patients who underwent surgery for giant benign skin tumors between 2015 and 2018 based on the literature definition of “giant benign skin tumors.” Demographic parameters, indications, symptoms, pathological results, and postoperative complications were evaluated retrospectively. Results: Sixteen patients (11 males and 5 females) were operated for giant benign skin tumors. The mean age of the patients was 53.38 (range: 37–72) years. Tumor locations were on the scalp for four patients, the upper extremity for three patients, lower extremity for three patients, trunk for five patients, and generalized for one patient. Pain was the most common symptom, and hypoesthesia, functional limitations, ulceration, and infection were also observed. Total excision was performed for all patients. No major complications and recurrence were observed. Conclusion: Clinical follow-up is an option for patients presenting to clinic with lesions that are small in size and asymptomatic. However, a detailed history and examination along with total excision and histopathological examination should be planned in patients with rapid progression or with benign skin tumors of giant size.

Renal fibroepithelial polyp (FEP) is a very rare tumour and we describe a case causing acute ureteric obstruction. A 56 year old lady presented with presumed pyelonephritis and left hydronephrosis, without calculi. She was transferred to a tertiary hospital urology service where after an unsuccessful retrograde attempt at stent insertion, a nephrostomy was inserted. Subsequently, the patient underwent a ureteropyeloscopy and excision of a FEP arising from the renal pelvis. Renal FEP is a very rare cause of obstruction and was successfully managed endoscopically.

Skin tags are benign growths typically found on intertriginous areas of the body. The most common type of skin tag is the acrochordon, skin-colored papules with short, broad stalks. A rarer type of skin tag is the fibroepithelial polyp (FEP), which tend to be larger, with long, narrow stalks. We evaluated a pediatric patient with a nipple lesion that was intermittently painful and discolored. Simple excision and primary closure was performed with excellent results and relief of symptoms. Pathology revealed benign FEP with a few benign lactiferous ducts at the base of the specimen. While the differential for benign nipple lesions is long, with only 8 documented cases of FEP of the breast and none documented in the pediatric population, this poses a diagnostic challenge. Literature shows that FEPs can grow to a large size over time and become increasingly symptomatic. The benefits of simple excision and primary closure of FEP of the nipple include improved cosmesis, improvement in symptoms, and reassurance for patient and family with benign pathology. Given the rarity of this lesion in both location and patient population, it is important for clinicians to differentiate FEP of the nipple from other benign and malignant growths.

Fibroepithelial polyps (FEP) are rare benign tumors urinary collecting system. Diagnosis is suspected on Computed Tomography (CT) and confirmed via histopathology. Treatment options vary from historic nephroureterectomy to more contemporary methods of ablation. Authors present a case of a symptomatic FEP causing left-sided hydronephrosis and episodic flank pain treated by a urologic surgeon. The patient underwent robotic pyeloplasty and excision of the tumors, yielding preserved renal function and resolution of the hydronephrosis., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)

A fibroepithelial polyp is a benign polypoidal lesion of mesodermal origin. It can present in any area of the body with an epithelial surface. These are relatively more common in skin and genitourinary tract and has been reported very rarely in head and neck region. We report here a rare presentation of fibroepithelial polyp in sinonasal cavity presenting with the symptoms of unilateral nasal obstruction. The patient underwent endoscopic surgical excision and recovered completely. In patients with unilateral sinonasal growing masses fibroepithelial polyp should be considered as one of the possible diagnoses. Sinonasal fibroepithelial polyps have good prognosis after being treated surgically. [ABSTRACT FROM AUTHOR]

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Chronic irritation to the mucosa manifests as reactive lesions or mucocele in pediatric population. Reactive lesions may range from developmental, inflammatory to neoplastic. Adverse oral habits such as lip biting and cheek biting also contribute to these types of oral lesions. We present a case of a 9-year-old pediatric patient who reported with the complaint of swelling in the right side of the lower lip and history of chronic lip biting. After intraoral examination, clinical diagnosis of mucocele was made. Following excision, the histopathological features were suggestive of fibroepithelial polyp. To avoid misdiagnosis, proper history, clinical and histopathological correlation is advisable to evade misdiagnosis and disparity between clinical and histopathological diagnosis.

We report the case of a 41-year-old pregnant female who presented with a complicated urinary tract infection. Further imaging revealed left hydronephrosis and filling defects extending from the proximal ureter to the upper pole of the kidney, with the presumed diagnosis of a fibroepithelial polyp. The patient underwent a four-stage percutaneous and ureteroscopic ablation and resection. Following the procedure, pathology instead confirmed the presence of a Mixed Epithelial and Stromal Tumor of the Kidney. For lesions that extend intraluminally into the ureters, a ureteroscopic and percutaneous resection can be considered as an alternative surgical approach.

Background: Fibroepithelial polyps located in the ureter constitute 2-6% of all benign tumors in the urinary system. Distinguishing these lesions from transitional cell carcinoma is essential to avoid unnecessary nephroureterectomy.Case Presentation: A 59-year-old asymptomatic caucasian male patient was enrolled in follow-up for Ta low-grade transitional cell bladder cancer 4 years ago in our clinic. A suspicious, solid, contrast-enhancing mass 15 × 9 mm in diameter in the anteromedial mid-section of the left kidney, which was causing minimal washout and largely located in the parenchyma, was reported as renal cell carcinoma on computed tomography during routine controls. In the excretory phase, soft-tissue densities of approximately 30 mm in length, which were located in the distal part of the left ureter at a distance of 40 mm from the ureterovesical junction, extending towards the lumen suggested a urethral carcinoma. Urothelial lesion was reported as fibroepithelial polyp after histopathological examination. Partial nephrectomy for the mass, which was reported as renal cell carcinoma in the left kidney, was performed in the first postoperative month. Histopathological examination revealed Fuhrman grade 1 papillary type renal cell carcinoma. No recurrence was observed in the first year after treatment.Conclusions: Although our patient had a bladder transitional cell carcinoma and a suspicious renal cell carcinoma mass of 15 mm in the ipsilateral kidney, the patient was safeguarded from unnecessary nephroureterectomy early on by cross-sectional and endoscopic imaging of the ureter. [ABSTRACT FROM AUTHOR]

BACKGROUND: Anal skin tags are commonly seen with anal fissures, haemorrhoids, inflammatory bowel disease and their association have been extensively studied. However the presence of anal skin tag in food protein-induced allergic proctocolitis has rarely been reported in literature. We report a neonate with food protein-induced allergic proctocolitis who presented with blood in stool and anal skin tag. CASE DESCRIPTION: A 26-day-old baby presented with history of passing intermittent blood in stools for two days. The baby was exclusively breast-fed and was well-appearing with no failure to thrive. Two anal skin tags were present but there was no evidence of anal fissures or haemorrhoids. The biopsy of anal skin tag showed fibroepithelial polyp. Colonoscopy was suggestive of food protein-induced allergic proctocolitis. In view of poor response to elimination diet in the mother and extensively hydrolysed formula, the baby was started on amino acid formula with complete recovery. CONCLUSION: Through this case we wish to highlight that clinicians should consider food protein-induced allergic proctocolitis in their differential diagnosis in a neonate presenting with blood in stools and anal skin tag. [ABSTRACT FROM AUTHOR]

Fibroepithelial polyps, which are rare, benign lesions arising from mesodermal tissue, are rarely seen in the oral cavity and upper airway. We report a case of a 55-year-old female who presented with dysphagia and sensation of a foreign body in the throat for five months duration. There was no history of change in voice, difficulty in breathing or history of trauma. Clinical examination revealed a 2x2 cm unilateral pedunculated mass over the superior pole of the left tonsil. The polyp was excised, and histopathological examination showed features suggestive of fibroepithelial polyp.

Genital stromal tumors are a rare and unique subset of soft-tissue tumors encountered in the vulvovaginal and inguinoscrotal region and this group includes fibroepithelial stromal polyp, superficial (cervicovaginal) myofibroblastoma, cellular angiofibroma, mammary-type myofibroblastoma, angiomyofibroblastoma, superficial angiomyxoma, and deep/aggressive angiomyxoma. The relative rarity and overlapping histomorphological and immunohistochemical features result in a diagnostic difficulty for the pathologists. Herein, we describe two cases of soft-tissue tumors in the vulvovaginal region presenting as polypoidal mass with detailed histopathology and immunohistochemical workup.

Fibroepithelial polyps are the most common benign neoplasm of ureter that originate from mesoderm. These polyps are one of the causes of hydronephrosis by obstructing the ureter. Etiology is not fully defined but there are some publications in the literature suggested that it is due to congenital, infectious, obstructive, traumatic, hormonal imbalances and irritative causes. A 36 years old male patient who admitted with left flank pain and fever. He had a history of endoscopic left ureteric stone surgery 3 years ago. In radiological evaluation with USG and CT, grade 3 hydroureteronephrosis was detected of the left kidney; however, no stone was detected. Ureterorenoscopy detected a 5x1 cm ureteral polyp in the distal ureter and punch biopsy confirmed fibroepithelial polyp. We performed laparoscopic excision of the polypoid segment and ureteroneocystostomy. Although it is rare, fibroepithelial polyp should be considered in hydronephrosis without any urinary stone or malignancy. [ABSTRACT FROM AUTHOR]

Fibroepithelial polyps represent a frequent cutaneous lesion of mesodermal origin, with a prevalence of 1.2% and are rarely located at palatine tonsils. We present a rare clinical report of a 70-year-old female patient with fibroepithelial polyp of palatine tonsil. This entity represents the eighth case of palatine tonsil fibroepithelial polyp in the English literature. She presented with a polypoid mass at the right tonsil and unspecified throat symptoms. Physicians should pay attention to such lesions because of the residual risk of malignant transformation, along with non-specific symptoms. Differential diagnosis was among neurofibroma, lipoma, squamous papilloma and fibroepithelial polyp. Histopathological examination following tonsillectomy showed a structure rich in vesicles inside lamina propria and surrounding inflammation, establishing the diagnosis of a fibroepithelial polyp. It requires vigilance during complete clinical examination, in order to detect masses at patients with throat symptoms that could have remained undiagnosed until they become even life threatening. [ABSTRACT FROM AUTHOR]

Background: Skin tags are common and mostly benign, but occasionally contain skin cancers. This study analysed skin tags by combining three advanced optical imaging technologies: reflectance confocal microscopy (RCM), optical coherence tomography (OCT) and multispectral optoacoustic imaging (MSOT) supplemented by dermoscopy Materials and methods: A prospective clinical study recruiting patients with skin tags from a university hospital clinic over a 2‐week period. OCT, RCM and MSOT imaging were performed prior to excisional biopsies. Image features such as pigmentation, cell types and skin architecture, angiographic information demonstrating vascular pattern were captured, analysed, and compared to melanin and haemoglobin content in MSOT as well as histopathology. Results: Six patients with dermal naevi (2); compound naevi (3); neurofibroma (1) were included. All skin tags except the neurofibroma were pigmented (5/6), with sparse (5/6) and dense (4/6) hyperreflective nests and band‐like collagen in dermis in 6/6 lesions on RCM. Dermoscopy showed dots (5/6) and coiled vessels (5/6). Linear vertical vessels were present in all OCT images. MSOT images consisted of a compact shell‐like superficial melanin area, same shape and size as the skin tag, dermal vessels were visible in 4/5 naevi, HbO2 signal clearly demarcated blood vessels located below the melanin signal. Conclusion: OCT showed linear vessels in all lesions. Pigmentation was identified by RCM as benign nests of melanocytes. MSOT supplemented with spatial distribution of melanin and HbO2 that indicated all skin tags were benign with no infiltration of vessels inside the melanin signal. Each advanced method proved indispensable for fast diagnosis. Larger studies are warranted for validation. [ABSTRACT FROM AUTHOR]

Fibroepithelial polyps (FEPs) are peculiar benign lesions that typically present as painless, pedunculated growths in various regions of the body, including the lower female genital tract. We discuss a case of a 45-year-old menopausal female who presented with an FEP in her vulva. The patient reported noticing a painless growth in her vulvar region for the past seven years, which had gradually increased in size. Clinical examination revealed a polypoidal, pedunculated, fleshy mass measuring approximately 11x8x7 cm in diameter. The lesion was excised under anesthesia, and histopathological examination confirmed the diagnosis of FEP. The patient had an uneventful postoperative course and showed no evidence of recurrence., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Tripathi et al.)