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Static quantitative magnetic resonance imaging (MRI) provides readouts of structural changes in diseased muscle, but current approaches lack the ability to fully explain the loss of contractile function. Muscle contractile function can be assessed using various techniques including phase‐contrast MRI (PC‐MRI), where strain rates are quantified. However, current two‐dimensional implementations are limited in capturing the complex motion of contracting muscle in the context of its three‐dimensional (3D) fiber architecture. The MR acquisitions (chemical shift‐encoded water–fat separation scan, spin echo‐echoplanar imaging with diffusion weighting, and two time‐resolved 3D PC‐MRI) wereperformed at 3 T. PC‐MRI acquisitions and performed with and without load at 7.5% of the maximum voluntary dorsiflexion contraction force. Acquisitions (3 T, chemical shift‐encoded water–fat separation scan, spin echo‐echo planar imaging with diffusion weighting, and two time‐resolved 3D PC‐MRI) were performed with and without load at 7.5% of the maximum voluntary dorsiflexion contraction force. Strain rates and diffusion tensors were calculated and combined to obtain strain rates along and perpendicular to the muscle fibers in seven lower leg muscles during the dynamic dorsi‐/plantarflexion movement cycle. To evaluate strain rates along the proximodistal muscle axis, muscles were divided into five equal segments. t‐tests were used to test if cyclic strain rate patterns (amplitude > 0) were present along and perpendicular to the muscle fibers. The effects of proximal‐distal location and load were evaluated using repeated measures ANOVAs. Cyclic temporal strain rate patterns along and perpendicular to the fiber were found in all muscles involved in dorsi‐/plantarflexion movement (p < 0.0017). Strain rates along and perpendicular to the fiber were heterogeneously distributed over the length of most muscles (p < 0.003). Additional loading reduced strain rates of the extensor digitorum longus and gastrocnemius lateralis muscle (p < 0.001). In conclusion, the lower leg muscles involved in cyclic dorsi‐/plantarflexion exercise showed cyclic fiber strain rate patterns with amplitudes that varied between muscles and between the proximodistal segments within the majority of muscles. [ABSTRACT FROM AUTHOR]

The C/C–SiC composites were fabricated by the liquid silicon infiltration method. The mechanical and tribological properties of C/C–SiC composites were assessed and compared based on different C/C densities and the carbon fiber textile architecture. The results demonstrated that the bending and shear strengths of C/C–SiC were lower than those of C/C composites, which resulted from the carbon fibers being corroded during the process of infiltration of liquid silicon. In contrast to C/C composites, the compressive strength of C/C–SiC exhibited higher values due to the presence of SiC ceramics. Moreover, the mechanical strength of C/C composites increased gradually with the increase of the C/C preform density. The tribological properties of various C/C–SiC composites showed a stable friction phase at an intermediate braking stage. When the density of C/C preforms was around 1.78 g/cm3, the C/C–SiC composites exhibited excellent friction coefficients (0.438 and 0.465), and low wear rates (linear and weight wear rates were 0.450 µm/time and 0.123 g/cycle, respectively). Furthermore, the C/C–SiC composites fabricated with non-woven carbon fiber needling preforms showed relatively a higher friction value and wear rate than those of C/C–SiC with PANOF integral C/C preforms. Therefore, C/C–SiC composites have been considered promising friction materials for braking system applications.

The object of the study was to reveal the fiber microstructural response with diffusion tensor cardiac magnetic resonance after intramyocardial exosomes secreted by cardiosphere-derived cells (CDCEXO) in chronic porcine myocardial infarction. Porcine with myocardial infarction underwent intramyocardial delivery of human CDCEXO and placebo in a randomized placebo-controlled study. Four weeks after injection, viability improved in the CDCEXO group, whereas myocardial fiber architecture and cardiac function were preserved. In the placebo group, fiber architecture and cardiac function declined. Myocardial regeneration by CDCEXO is not tumor-like; instead, details of tissue architecture are faithfully preserved, which may foster physiological excitation and contraction.

Bu çalışmada, kurbağa gastrocnemius (plantaris longus olarak da bilinmektedir) kasının sayısal modelini oluşturarak sonlu elemanlar yöntemi (SEY) ile kasılma davranışı incelenmiştir. Bu amaçla sonlu elemanlar yöntemi ile çalışan bir fiziksel gerçeklik benzetim senaryosu oluşturulmuştur. Bu senaryo dahilinde, çapraz-bağ kinetik modelini dağıtık-moment yaklaşımını kullanarak çözen sonlu elemanlar yöntemi ile oluşturulmuş kas modeli, kas üzerinde ince bir zar şeklinde bulunan aponevroz örtüsünün açısal yerleşiminin, kasılma sonucunda oluşan toplam çekme kuvveti üzerindeki etkisini incelemek üzere kullanılmıştır. Bununla birlikte, kas modelinde lif yöneliminin etkisinin incelenmesi amacıyla yönelim eksenel (sabit eksen yönünde) ve fusiform (kas geometrisini takip eden) olarak iki tipte örneklenerek üretilen çekme kuvveti ve yakınsama üzerindeki etkileri değerlendirilmiştir. Ayrıca, elde edilen veriler, gerçek bir kurbağa kasından laboratuvar ortamında elde edilmiş verilerle karşılaştırılmıştır. Sonuç olarak, aponevroz örtüsünün şeklinin ve lif yöneliminin kas modeli üzerinde üretilen çekme kuvveti ve yakınsama özellikleri bakımından ayırt edici ve önemli etkileri olduğu deneyimlenmiş, kullanılan modelin 3 boyutlu kas modellemesine uygun olabileceği görülmüştür.

Myocardial infarction leads to complex changes in the fiber architecture of the heart. Here, we present a novel optical approach to characterize these changes in intact hearts in three dimensions. Optical coherence tomography (OCT) was used to derive a depth-resolved field of orientation on which tractography was performed. Tractography of healthy myocardium revealed a smooth linear transition in fiber inclination or helix angle from the epicardium to endocardium. Conversely, in infarcted hearts, no coherent microstructure could be identified in the infarct with OCT Additional characterization of the infarct was performed by the measurement of light attenuation and with two-photon microscopy. Myofibers were imaged using autofluorescence and collagen fibers using second harmonic generation. This revealed the presence of two distinct microstructural patterns in areas of the infarct with high light attenuation. In the presence of residual myofibers, the surrounding collagen fibers were aligned in a coherent manner parallel to the myofibers. In the absence of residual myofibers, the collagen fibers were randomly oriented and lacked any microstructural coherence. The presence of residual myofibers thus exerts a profound effect on the microstructural properties of the infarct scar and consequently the risk of aneurysm formation and arrhythmias. Catheter-based approaches to segment and image myocardial microstructure in humans are feasible and could play a valuable role in guiding the development of strategies to improve infarct healing.

The use of CFRP composites is significantly increasing in the aerospace, automotive, and marine industries, particularly in safety critical primary structures. This work presents a newly developed experimental approach to investigate the directional diffusion of water in CFRP composites with the use of Fick's law. The approach is used to study the effect of fiber architecture on directional diffusion rates, with a particular focus on the role of fiber waviness in the diffusion process. A comparison of water diffusion is made in three different fiber architectures: Unidirectional (UD), plain weave, and twill weave. The specimens were fully immersed in 90°C purified water until their maximum moisture saturation was achieved, with some specimens being selectively exposed from the edges only to obtain the directional diffusion coefficients. The water penetration process into the CFRP structure initiate from the micro‐cracks and defects. The experimental work of this study shows sharp mass increases within the first stage followed by an equilibrium stage where saturation is present. The interfacial region is found to be a critical parameter where detachment of the interfacial fiber/matrix bonding is observed further demonstrating the potential effect of different fiber architecture in this region. UD fiber architecture showed ~20% higher diffusion coefficient in the Dx,y direction compared with plain and twill woven architectures. The weave patterns in 2D woven fiber architectures are therefore believed to play a key role on the moisture ingress mechanism and subsequently contributed in slowing down the capillary process in the interfacial region. This has implications for materials development and selection for CFRP composites used in moist environments. [ABSTRACT FROM AUTHOR]

In the present study, the effect of fiber architecture on mechanical properties of E‐glass fiber reinforced polymer composite has been investigated experimentally. The influence of fiber volume fraction on strength of composite has also been predicted using second order polynomial regression models. The glass fibers were arranged in different architecture like unidirectional continuous, unidirectional discontinuous, short randomly oriented, transversely aligned, and woven for preparation of composites. The tensile and flexural tests were performed as per ASTM D3039 and ASTM D790, respectively. The experimental results of tensile and flexural properties of composites have been discussed. Results predicted by the regression models are in good agreement with experimental results which indicate the goodness of fit and the models are statistically significant. [ABSTRACT FROM AUTHOR]

The object of the study was to reveal the fiber microstructural response with diffusion tensor cardiac magnetic resonance after intramyocardial exosomes secreted by cardiosphere-derived cells (CDCEXO) in chronic porcine myocardial infarction. Porcine with myocardial infarction underwent intramyocardial delivery of human CDCEXO and placebo in a randomized placebo-controlled study. Four weeks after injection, viability improved in the CDCEXO group, whereas myocardial fiber architecture and cardiac function were preserved. In the placebo group, fiber architecture and cardiac function declined. Myocardial regeneration by CDCEXO is not tumor-like; instead, details of tissue architecture are faithfully preserved, which may foster physiological excitation and contraction.

This paper reports the effects of temperature and fiber architecture on the shear properties and failure mechanism of 3D MWK composites under compressive loading at room and elevated temperatures. The shear experiments of composites with three fiber architectures were performed at five different temperatures. Macro-fracture and SEM micrographs were examined to understand the deformation and shear failure mechanism. The results show that shear stress-strain curves show non-linearity and plastic fracture feature, and exhibit plastic platform at elevated temperatures. The temperature has significant effects on the shear properties which decrease significantly with increasing the temperature due to degradation of matrix properties, especially after 75 oC. The shear properties can be affected greatly by the fiber architecture and these increase significantly with the increase of 45 o direction fiber at different temperatures. The results also show that the damage and failure patterns of composites vary with the fiber architecture and temperature. At room temperature, the interfacial adhesion between fibers and matrix is high, the local delaminating and shear failure feature are prominent. At elevated temperatures, the composites become more softened, cracked and attain plasticity. The damage of matrix plastic and cracking, interface debonding, and fiber layer delaminating change significantly. [ABSTRACT FROM AUTHOR]

This study is aimed at comparing the response and damage of unidirectional (UD), woven fabric (WF) and hybrid UD/WF fiber reinforced polymer (FRP) laminates subjected to low velocity impact. The unidirectional tape and/or woven fabric (plain weave) carbon/epoxy prepregs are laminated and hot-pressed to produce UD, WF and sandwich-like hybrid UD/WF specimens. Impact responses of specimens are determined through low velocity impact (LVI) tests with impact energies of 10 J, 17 J and 25 J. After the LVI tests, the damage of specimens is characterized and analyzed using a combination of visual inspection, ultrasonic phased-array inspection, micro-computed tomography (CT) inspection, cross-sectional microscopic observation, and thermal de-ply test. Also, the LVI damage mechanisms of the three types of specimens are quantitatively compared by using the inter fiber crack volume ratio, total delamination area and fiber fracture length. It is concluded that the fiber architecture plays an important role in determining low velocity impact behavior of composite laminates. Especially, for the sandwich-like hybrid UD/WF laminates whose surface is a WF layer and the core is a UD layer, the WF layer on the surface plays an important role in reducing matrix cracking, delamination and fiber fracture, thus improving its LVI resistance. [Display omitted] • The LVI performance of three types of laminates, UD, WF and hybrid UD/WF laminates, was experimentally compared. • The LVI damage mechanisms of laminates were quantitatively compared by using the IFCVR, TDA and FFL. • The impact damage was characterized and analyzed by combining several NDT and DT methods. [ABSTRACT FROM AUTHOR]

3D-Polarized Light Imaging (3D-PLI) enables high-resolution three-dimensional mapping of the nerve fiber architecture in unstained histological brain sections based on the intrinsic birefringence of myelinated nerve fibers. The interpretation of the measured birefringent signals comes with conjointly measured information about the local fiber birefringence strength and the fiber orientation. In this study, we present a novel approach to disentangle both parameters from each other based on a weighted least squares routine (ROFL) applied to oblique polarimetric 3D-PLI measurements. This approach was compared to a previously described analytical method on simulated and experimental data obtained from a post mortem human brain. Analysis of the simulations revealed in case of ROFL a distinctly increased level of confidence to determine steep and flat fiber orientations with respect to the brain sectioning plane. Based on analysis of histological sections of a human brain dataset, it was demonstrated that ROFL provides a coherent characterization of cortical, subcortical, and white matter regions in terms of fiber orientation and birefringence strength, within and across sections. Oblique measurements combined with ROFL analysis opens up new ways to determine physical brain tissue properties by means of 3D-PLI microscopy.

Background: Urinary incontinence is a major clinical problem arising primarily from age-related degenerative changes to the sphincter muscles. However, the precise anatomy of the normal male sphincter muscles has yet to be established. Diffusion tensor imaging (DTI) may offer a unique insight into muscle microstructure and fiber architecture.Purpose: To explore the anatomy of the urethral sphincter muscles pertinent to urinary continence function using DT-MRI.Study Type: Prospective cohort study.Subjects: Eleven normal male subjects (mean age: 25.4 years); two subjects were scanned in three separate sessions to assess reproducibility.Field Strength/sequence: 3T; using a diffusion-weighted spin echo planar sequence.Assessment: DT parameters including fractional anisotropy (FA), primary (λ1 ), secondary (λ2 ), and tertiary (λ3 ) eigenvalues, Apparent diffusion coefficient and radial diffusivity were analyzed statistically, while tracked muscle fibers were assessed visually.Statistical Tests: Regional differences (sphincters and longitudinal muscle of the urethra) in the DTI indices were assessed by one-way analysis of variance. A Tukey post-hoc test was used to identify significant differences between muscle regions.Results: Two sphincter muscles, one proximal near the base of the bladder, corresponding to the lisso-sphincter, and the other distal to the end of the prostate corresponding to the rhabdo-sphincter, surrounding a central urethral muscle fiber bundle, were clearly identified. FA was higher and λ3 lower in the proximal sphincter muscle compared to the central urethral muscle and the distal sphincter (P < 0.05). The average coefficient of variation ranged from 5-12% for the DTI indices.Data Conclusion: Since DTI values are known to reflect underlying tissue microarchitecture, significant differences in DTI indices identified here between the muscles of the urethral complex may potentially arise from differences in tissue microarchitecture that may in turn be related to the specific function of the sphincter and other muscles.Level Of Evidence: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;48:1002-1011. [ABSTRACT FROM AUTHOR]

3D-Polarized Light Imaging (3D-PLI) enables high-resolution three-dimensional mapping of the nerve fiber architecture in unstained histological brain sections based on the intrinsic birefringence of myelinated nerve fibers. The interpretation of the measured birefringent signals comes with conjointly measured information about the local fiber birefringence strength and the fiber orientation. In this study, we present a novel approach to disentangle both parameters from each other based on a weighted least squares routine (ROFL) applied to oblique polarimetric 3D-PLI measurements. This approach was compared to a previously described analytical method on simulated and experimental data obtained from a post mortem human brain. Analysis of the simulations revealed in case of ROFL a distinctly increased level of confidence to determine steep and flat fiber orientations with respect to the brain sectioning plane. Based on analysis of histological sections of a human brain dataset, it was demonstrated that ROFL provides a coherent characterization of cortical, subcortical, and white matter regions in terms of fiber orientation and birefringence strength, within and across sections. Oblique measurements combined with ROFL analysis opens up new ways to determine physical brain tissue properties by means of 3D-PLI microscopy. [ABSTRACT FROM AUTHOR]

BackgroundStructural remodeling of human atria plays a key role in sustaining atrial fibrillation (AF), but insufficient quantitative analysis of human atrial structure impedes the treatment of AF. We aimed to develop a novel 3‐dimensional (3D) structural and computational simulation analysis tool that could reveal the structural contributors to human reentrant AF drivers. Methods and ResultsHigh‐resolution panoramic epicardial optical mapping of the coronary‐perfused explanted intact human atria (63‐year‐old woman, chronic hypertension, heart weight 608 g) was conducted during sinus rhythm and sustained AF maintained by spatially stable reentrant AF drivers in the left and right atrium. The whole atria (107×61×85 mm3) were then imaged with contrast‐enhancement MRI (9.4 T, 180×180×360‐μm3 resolution). The entire 3D human atria were analyzed for wall thickness (0.4–11.7 mm), myofiber orientations, and transmural fibrosis (36.9% subendocardium; 14.2% midwall; 3.4% subepicardium). The 3D computational analysis revealed that a specific combination of wall thickness and fibrosis ranges were primarily present in the optically defined AF driver regions versus nondriver tissue. Finally, a 3D human heart–specific atrial computer model was developed by integrating 3D structural and functional mapping data to test AF induction, maintenance, and ablation strategies. This 3D model reproduced the optically defined reentrant AF drivers, which were uninducible when fibrosis and myofiber anisotropy were removed from the model. ConclusionsOur novel 3D computational high‐resolution framework may be used to quantitatively analyze structural substrates, such as wall thickness, myofiber orientation, and fibrosis, underlying localized AF drivers, and aid the development of new patient‐specific treatments.

Electrospun fibers have emerged as a relatively new delivery platform to improve active agent retention and delivery for intravaginal applications. While uniaxial fibers have been explored in a variety of applications including intravaginal delivery, the consideration of more advanced fiber architectures may offer new options to improve delivery to the female reproductive tract. In this review, we summarize the advancements of electrospun coaxial, multilayered, and nanoparticle-fiber architectures utilized in other applications and discuss how different material combinations within these architectures provide varied durations of release, here categorized as either transient (within 24 h), short-term (24 h to one week), or sustained (beyond one week). We seek to systematically relate material type and fiber architecture to active agent release kinetics. Last, we explore how lessons derived from these architectures may be applied to address the needs of future intravaginal delivery platforms for a given prophylactic or therapeutic application. The overall goal of this review is to provide a summary of different fiber architectures that have been useful for active agent delivery and to provide guidelines for the development of new formulations that exhibit release kinetics relevant to the time frames and the diversity of active agents needed in next-generation multipurpose applications.

The paper reviews the characterization of high-performance hybrid textile composites and their hybridization effects of composite's behavior. Considered are research works based on the finite-element modeling, simulation, and experimental characterization of various mechanical properties of such composites. [ABSTRACT FROM AUTHOR]

Heterogeneities in structure and stress within heart valve leaflets are of significant concern to their functional physiology, as they affect how the tissue constituents remodel in response to pathological and non-pathological (e.g. exercise, pregnancy) alterations in cardiac function. Indeed, valve interstitial cells (VICs) are known to synthesize and degrade leaflet extracellular matrix (ECM) components in a manner specific to their local micromechanical environment. Quantifying local variations in ECM structure and stress is thus necessary to understand homeostatic valve maintenance as well as to develop predictive models of disease progression and post-surgical outcomes. In the aortic valve (AV), transmural variations in stress have previously been investigated by modeling the leaflet as a composite of contiguous but mechanically distinct layers. Based on previous findings about the bonded nature of these layers ( Buchanan and Sacks, BMMB, 2014 ), we developed a more generalized structural constitutive model by treating the leaflet as a functionally graded material (FGM), whose properties vary continuously over the thickness. We informed the FGM model using high-resolution morphological measurements, which demonstrated that the composition and fiber structure change gradually over the thickness of the AV leaflet. For validation, we fit the model against an extensive database of whole-leaflet and individual-layer mechanical responses. The FGM model predicted large stress variations both between and within the leaflet layers at end-diastole, with low-collagen regions bearing significant radial stress. These novel results suggest that the continually varying structure of the AV leaflet has an important purpose with regard to valve function and tissue homeostasis. [ABSTRACT FROM AUTHOR]

This paper presents the three-point bending properties of 3D needle-punched composites with two fiber architectures at room and elevated temperatures. The influences of temperature and fiber architectures on the load/deflection curves, bending strength and bending stiffness are analyzed. Macro-Fracture morphology and SEM micrographs are examined to understand the damage and failure mechanism. The results show that the bending properties of plain structure needle-punched composites are superior to those with non-woven structure. Meanwhile, the bending properties of composites decrease significantly with the increase of testing temperature. Moreover, the damage and failure patterns of composites vary with fiber architecture and testing temperatures. For the plain structure, 90 ° and 0 ° fiber bundles can bear the load together. At room temperature, the composite shows brittle fracture feature and exhibits local damage with matrix cracking, breakage and tearing of the fibers. While at a higher temperature, the composite shows less fracture and becomes more softened and plastic. It damages with matrix cracking, falling off and plastic deformation, fiber layer/web delaminating, and interface debonding. [ABSTRACT FROM AUTHOR]

Research of the human brain connectome requires multiscale approaches derived from independent imaging methods ideally applied to the same object. Hence, comprehensible strategies for data integration across modalities and across scales are essential. We have successfully established a concept to bridge the spatial scales from microscopic fiber orientation measurements based on 3D-Polarized Light Imaging (3D-PLI) to meso- or macroscopic dimensions. By creating orientation distribution functions (pliODFs) from high-resolution vector data via series expansion with spherical harmonics utilizing high performance computing and supercomputing technologies, data fusion with Diffusion Magnetic Resonance Imaging has become feasible, even for a large-scale dataset such as the human brain. Validation of our approach was done effectively by means of two types of datasets that were transferred from fiber orientation maps into pliODFs: simulated 3D-PLI data showing artificial, but clearly defined fiber patterns and real 3D-PLI data derived from sections through the human brain and the brain of a hooded seal.

The paper summarizes main principles of an advanced skeletal muscle model. The proposed mathematical model is suitable for a 3D muscle representation. It respects the microstructure of the muscle which is represented by three basic components: active fibers, passive fibers and a matrix. For purposes of presented work the existing material models suitable for the matrix and passive fibers are used and a new active fiber model is proposed. The active fiber model is based on the sliding cross-bridge theory of contraction. This theory is often used in modeling of skeletal and cardiac muscle contractions. In this work, a certain simplification of the cross-bridge distribution function is proposed, so that the 3D computer implementation becomes feasible. The new active fiber model is implemented into our research finite element code. A simple 3D muscle bundle-like model is created and the implemented composite model (involving the matrix, passive and active fibers) is used to perform the isometric, concentric and excentric muscle contraction simulations.

A new stereotaxic brain atlas of the Mongolian gerbil ( Meriones unguiculatus), an important animal model in neurosciences, is presented. It combines high-quality histological material for identification of brain structures with reliable stereotaxic coordinates. The atlas consists of high-resolution images of frontal sections alternately stained for cell bodies (Nissl) and myelinated fibers (Gallyas) of 62 rostro-caudal levels at intervals of 350 μm. Brain structures were named according to the Paxinos nomenclature for rodents. The accuracy of the stereotaxic coordinate system was improved substantially by comparing and matching the series of histological sections to in vivo brain images of the gerbil obtained by magnetic resonance imaging (MRI). The skull outlines corresponding to the MR images were acquired using X-ray computerized tomography (CT) and were used to establish the relationship between coordinates of brain structures and skull. Landmarks such as lambda, bregma, ear canals and occipital crest can be used to line up skull and brain in standard atlas coordinates. An easily reproducible protocol allows sectioning of experimental brains in the standard frontal plane of the atlas. [ABSTRACT FROM AUTHOR]

Purpose: The arrangement or architecture of myocardial cells plays a fundamental role in the heart's function and its change was shown to be directly linked to heart diseases. Inhomogeneity level is an important index of myocardial cell arrangements in the human heart. The authors propose to investigate the inhomogeneity level of myocardial cells using polarized light imaging simulations and experiments. Methods: The idea is based on the fact that the myosin filaments in myocardial cells have the same properties as those of a uniaxial birefringent crystal. The method then consists in modeling the myosin filaments of myocardial cells as uniaxial birefringent crystal, simulating the behavior of the latter by means of the Mueller matrix, and measuring the final intensity of polarized light and consequently the inhomogeneity level of myocardial cells in each voxel through the use of crossed polarizers. The method was evaluated on both simulated and real tissues and under various myocardial cell configurations including parallel cells, crossed cells, and cells with random orientations. Results: When myocardial cells run perfectly parallel to each other, all the polarized light was blocked by those parallel myocardial cells, and a high homogeneity level was observed. However, if myocardial cells were not parallel to each other, some leakage of the polarized light was observed, thus causing the decrease of the polarized light amplitude and homogeneity level. The greater the crossing angle between myocardial cells, the smaller the amplitude of the polarized light and the greater the inhomogeneity level. For two populations of myocardial cell crossing at an angle, the resulting azimuth angle of the voxel was the bisector of this angle. Moreover, the value of the inhomogeneity level began to decrease from a nonzero value when the voxel was not totally homogeneous, containing for example cell crossing. Conclusions: The proposed method enables the physical information of myocardial tissues to be estimated and the inhomogeneity level of a volume or voxel to be quantified, which opens new ways to study the microstructures of the human myocardium and helps understanding how heart diseases modify myocardial cells and change their mechanical properties. [ABSTRACT FROM AUTHOR]

The three-point bending experiments on three-dimensional multiaxial warp-knitted carbon/epoxy composites with two fiber architectures are performed at room and elevated temperatures. Macro-fracture morphology and scanning electron microscopic micrographs are examined to understand the deformation and failure mechanism. The results show that the load–deflection curves are significantly different for different temperatures and the bending properties decrease significantly with increasing the temperature. Meanwhile, bending properties can be affected greatly by the fiber architecture and these increase significantly with the decrease of the fiber orientation angle at different temperatures. The results also show that the damage and failure patterns of composites vary with the test temperature. At room temperature, the composite exhibits brittle feature, and it damages with the breakage and tearing of fibers. At elevated temperature, the composite becomes more softened and exhibits plasticity. The damage of matrix plastic and cracking, interface debonding, and fiber layer delaminating become prominent. Moreover, the failure mechanism at room and elevated temperatures can be significantly affected by the fiber architecture. [ABSTRACT FROM AUTHOR]

Three-point bending experiments on 3D multi-axial warp knitted composites with four fiber architectures are performed at room and liquid nitrogen temperatures. Macro-fracture morphology and scanning electron microscope micrographs are examined to understand the deformation and failure mechanism. The results show that the load–deflection curves are significantly different for four types of composites and the bending properties decrease with the increase of fiber orientation angle at room and liquid nitrogen temperatures. Meanwhile, the bending properties at liquid nitrogen temperature have been improved significantly than that of at room temperature. Moreover, the damage and failure patterns of composites vary with the test temperature. At liquid nitrogen temperature, the interfacial adhesion strength is enhanced significantly and the brittle failure feature becomes more obvious. In addition, the failure mechanism at room and liquid nitrogen temperatures can be significantly affected by the fiber architecture. [ABSTRACT FROM AUTHOR]