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Your search keyword '"Fhu, Chee Wai"' showing total 14 results
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14 results on '"Fhu, Chee Wai"'

1. Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer

Author

Maroni, Giorgia, Bassal, Mahmoud A., Krishnan, Indira, Fhu, Chee Wai, Savova, Virginia, Zilionis, Rapolas, Maymi, Valerie A., Pandell, Nicole, Csizmadia, Eva, Zhang, Junyan, Storti, Barbara, Castaño, Julio, Panella, Riccardo, Li, Jia, Gustafson, Corinne E., Fox, Sam, Levy, Rachel D., Meyerovitz, Claire V., Tramontozzi, Peter J., Vermilya, Kimberly, De Rienzo, Assunta, Crucitta, Stefania, Bassères, Daniela S., Weetall, Marla, Branstrom, Art, Giorgetti, Alessandra, Ciampi, Raffaele, Del Re, Marzia, Danesi, Romano, Bizzarri, Ranieri, Yang, Henry, Kocher, Olivier, Klein, Allon M., Welner, Robert S., Bueno, Raphael, Magli, Maria Cristina, Clohessy, John G., Ali, Azhar, Tenen, Daniel G., and Levantini, Elena

Published
2021
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2. A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma

Author

Kong, Li Ren, Mohamed Salleh, Nur Afiqah Binte, Ong, Richard Weijie, Tan, Tuan Zea, Syn, Nicholas L., Goh, Robby Miguel, Fhu, Chee Wai, Tan, Daniel S. W., Iyer, N. Gopalakrishna, Kannan, Srinivasaraghavan, Verma, Chandra S., Lim, Yaw Chyn, Soo, Ross, Ho, Jingshan, Huang, Yiqing, Lim, Joline S. J., Yan, Benedict Junrong, Nga, Min En, Lim, Seng Gee, Koeffler, H. Phillip, Lee, Soo Chin, Kappei, Dennis, Hung, Huynh The, and Goh, Boon Cher

Published
2020
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4. Targeting microtubule sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors

Author

Daniel G. Tenen, Fhu Chee Wai, Elena Levantini, Thomas C. Putti, Wanjin Hong, Eva Csizmadia, Jeff Settleman, John G. Clohessy, Margaret P. Quinlan, Chen Xie, Azhar Ali, Tan Min Chin, Ellen P S Man, Boon Cher Goh, Seow-Ching Wan, Gandhi T K Boopathy, and Yan Shan Ong

Subjects
0301 basic medicine, Genetically modified mouse, Lung Neoplasms, Endosome, Medicine (miscellaneous), Antineoplastic Agents, Mice, Transgenic, EGFR mutants, Magnetic resonance Imaging, Molecular pathogenesis of lung cancer, NSCLC, Immunofluorescence, Microtubules, chloroquine, Drug treatment, Mice, 03 medical and health sciences, 0302 clinical medicine, Microtubule, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Lysosome, Chlorocebus aethiops, tyrosine kinase inhibitors, medicine, Animals, Humans, Protein Kinase Inhibitors, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Preclinical murine model of lung cancer, medicine.diagnostic_test, LAMP1, Chemistry, Kinase, 3. Good health, ErbB Receptors, 030104 developmental biology, medicine.anatomical_structure, Drug Resistance, Neoplasm, Tumor progression, EGFR mutant lung cancer therapy, 030220 oncology & carcinogenesis, COS Cells, Cancer research, Lysosomes, microtubule dysfunction, Research Paper
Abstract

Oncogene-addicted cancers are predominantly driven by specific oncogenic pathways and display initial exquisite sensitivity to designer therapies, but eventually become refractory to treatments. Clear understanding of lung tumorigenic mechanisms is essential for improved therapies. Methods: Lysosomes were analyzed in EGFR-WT and mutant cells and corresponding patient samples using immunofluorescence or immunohistochemistry and immunoblotting. Microtubule organization and dynamics were studied using immunofluorescence analyses. Also, we have validated our findings in a transgenic mouse model that contain EGFR-TKI resistant mutations. Results: We herein describe a novel mechanism that a mutated kinase disrupts the microtubule organization and results in a defective endosomal/lysosomal pathway. This prevents the efficient degradation of phosphorylated proteins that become trapped within the endosomes and continue to signal, therefore amplifying downstream proliferative and survival pathways. Phenotypically, a distinctive subcellular appearance of LAMP1 secondary to microtubule dysfunction in cells expressing EGFR kinase mutants is seen, and this may have potential diagnostic applications for the detection of such mutants. We demonstrate that lysosomal-inhibitors re-sensitize resistant cells to EGFR tyrosine-kinase inhibitors (TKIs). Identifying the endosome-lysosome pathway and microtubule dysfunction as a mechanism of resistance allows to pharmacologically intervene on this pathway. Conclusions: We find that the combination of microtubule stabilizing agent and lysosome inhibitor could reduce the tumor progression in EGFR TKI resistant mouse models of lung cancer.

Published
2020
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5. Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor

Author

Pang, Kuin Tian, primary, Ghim, Mean, additional, Liu, Chenghao, additional, Tay, Hui Min, additional, Fhu, Chee Wai, additional, Chia, Rui Ning, additional, Qiu, Beiying, additional, Sarathchandra, Padmini, additional, Chester, Adrian H., additional, Yacoub, Magdi H., additional, Wilkinson, Fiona L., additional, Weston, Ria, additional, Warboys, Christina M., additional, Hou, Han Wei, additional, Weinberg, Peter D., additional, and Wang, Xiaomeng, additional

Published
2021
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11. The fetal mouse metatarsal bone explant as a model of angiogenesis

Author

Song, Weihua, primary, Fhu, Chee Wai, additional, Ang, Koon Hwee, additional, Liu, Cheng Hao, additional, Johari, Nurul Azizah Binte, additional, Lio, Daniel, additional, Abraham, Sabu, additional, Hong, Wanjin, additional, Moss, Stephen E, additional, Greenwood, John, additional, and Wang, Xiaomeng, additional

Published
2015
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