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Your search keyword '"Ffrench-Mullen, J. M. H."' showing total 15 results
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15 results on '"Ffrench-Mullen, J. M. H."'

10. GABA-A receptor alpha-4 subunit suppression prevents withdrawal properties of an endogenous steroid.

Author

Smith, Sheryl S., Qi Hua Gong, Fu-Chun Hsu, Markowitz, Ronald S., ffrench-Mullen, J. M. H., and Xinshe Li

Subjects
PREMENSTRUAL syndrome, PROGESTERONE, PHYSIOLOGY
Abstract

Presents research which studied the relation between premenstrual syndrome (PMS) and progesterone withdrawal. Conversion of progesterone in human brains; Symptoms of PMS tied to declines in levels of progesterone; Description of a progesterone-withdrawal paradigm; Cause of increased susceptibility to seizure after progesterone withdrawal; Prevention of withdrawal properties; Partial cause of PMS symptoms.

Published
1998
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13. Calcium current characterization in dissociated adult guineapig jugular ganglion neurons

Author

Danks, P., Spence, K. T., Togo, J. A., Christian, E. P., and ffrench-Mullen, J. M. H.

Abstract

VOLTAGE-DEPENDENT calcium (Ca2) channel currents in freshly dissociated adult guinea-pig jugular ganglion neurons were examined and characterized using the whole-cell patch-clamp technique. Electrophysiological analysis demonstrated a high-threshold current, but no low-threshold or T-type current. A fraction of the total Ca2current was inhibited by omega (ω)-conotoxin GVIA (Cg (in TX; 10 μM); the dihydropyridine antagonist nifedipine (NIF; 10 μM), inhibited a large fraction of the CgTX-insensitive current. The remaining CgTX/NIF-insensitive current was completely inhibited by ω-agatoxin IVA (AgIVA; 100 nM). These results demonstrated that the whole-cell Ca2channel current consisted only of N-, L-P-type components. Of these currents, only the L-type was partially inhibited by both histamine and carbachol (0.01–100 μM).

Published
1994

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