515 results on '"Feusner, Jamie D."'
Search Results
2. The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium
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Bruin, Willem B., Abe, Yoshinari, Alonso, Pino, Anticevic, Alan, Backhausen, Lea L., Balachander, Srinivas, Bargallo, Nuria, Batistuzzo, Marcelo C., Benedetti, Francesco, Bertolin Triquell, Sara, Brem, Silvia, Calesella, Federico, Couto, Beatriz, Denys, Damiaan A. J. P., Echevarria, Marco A. N., Eng, Goi Khia, Ferreira, Sónia, Feusner, Jamie D., Grazioplene, Rachael G., Gruner, Patricia, Guo, Joyce Y., Hagen, Kristen, Hansen, Bjarne, Hirano, Yoshiyuki, Hoexter, Marcelo Q., Jahanshad, Neda, Jaspers-Fayer, Fern, Kasprzak, Selina, Kim, Minah, Koch, Kathrin, Bin Kwak, Yoo, Kwon, Jun Soo, Lazaro, Luisa, Li, Chiang-Shan R., Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Menchon, Jose M., Moreira, Pedro S., Morgado, Pedro, Nakagawa, Akiko, Nakao, Tomohiro, Narayanaswamy, Janardhanan C., Nurmi, Erika L., Zorrilla, Jose C. Pariente, Piacentini, John, Picó-Pérez, Maria, Piras, Fabrizio, Piras, Federica, Pittenger, Christopher, Reddy, Janardhan Y. C., Rodriguez-Manrique, Daniela, Sakai, Yuki, Shimizu, Eiji, Shivakumar, Venkataram, Simpson, Blair H., Soriano-Mas, Carles, Sousa, Nuno, Spalletta, Gianfranco, Stern, Emily R., Evelyn Stewart, S., Szeszko, Philip R., Tang, Jinsong, Thomopoulos, Sophia I., Thorsen, Anders L., Yoshida, Tokiko, Tomiyama, Hirofumi, Vai, Benedetta, Veer, Ilya M., Venkatasubramanian, Ganesan, Vetter, Nora C., Vriend, Chris, Walitza, Susanne, Waller, Lea, Wang, Zhen, Watanabe, Anri, Wolff, Nicole, Yun, Je-Yeon, Zhao, Qing, van Leeuwen, Wieke A., van Marle, Hein J. F., van de Mortel, Laurens A., van der Straten, Anouk, van der Werf, Ysbrand D., Thompson, Paul M., Stein, Dan J., van den Heuvel, Odile A., and van Wingen, Guido A.
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- 2023
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3. Neural, physiological, and psychological markers of appetitive conditioning in anorexia nervosa: a study protocol
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Murray, Stuart B, Zbozinek, Tomislav D, Craske, Michelle, Tadayonnejad, Reza, Strober, Michael, Bari, Ausaf A, O’Doherty, John P, and Feusner, Jamie D
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Anorexia ,Nutrition ,Mental Health ,Clinical Research ,Basic Behavioral and Social Science ,Eating Disorders ,Pediatric ,Brain Disorders ,Neurosciences ,Behavioral and Social Science ,Mental health ,Anorexia nervosa ,Eating disorders ,Reward ,Appetitive conditioning ,fMRI ,Nutrition and Dietetics ,Psychology - Abstract
BackgroundAnorexia nervosa (AN) is a chronic and disabling psychiatric condition characterized by low hedonic drive towards food, and is thought to be inclusive of altered dimensions of reward processing. Whether there exists a fundamental aberrancy in the capacity to acquire and maintain de novo hedonic associations-a critical component of hedonic responding-has never been studied in AN.MethodsThis multi-modal study will employ a 2-day Pavlovian appetitive conditioning paradigm to interrogate the (1) acquisition, (2) extinction, (3) spontaneous recovery and (4) reinstatement of appetitive learning in adolescents and young adults with AN. Participants will be 30 currently ill, underweight individuals with AN; 30 weight-restored individuals with AN; and 30 age-matched healthy controls, all aged 12-22 years. All subjects will undergo clinical assessment, followed by the 2-day appetitive conditioning task during which fMRI, pupillometry, heart rate deceleration, and subjective ratings will be acquired.DiscussionThis study will be the first to interrogate appetitive conditioning in AN-a disorder characterized by altered hedonic responding to food. Results will help establish objective biomarkers of appetitive conditioning in AN and lay the groundwork for developing novel lines of treatment for AN and other psychiatric disorders involving diminished ability to experience pleasure and reward.Trial registrationPending.Intended registryClinicaltrials.gov.
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- 2022
4. Neural representations of anxiety in adolescents with anorexia nervosa: a multivariate approach
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Seiger, René, Reggente, Nicco, Majid, D.S.-Adnan, Ly, Ronald, Tadayonnejad, Reza, Strober, Michael, and Feusner, Jamie D.
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- 2023
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5. Neurosurgery and neuromodulation for anorexia nervosa in the 21st century: a systematic review of treatment outcomes
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Murray, Stuart B, Strober, Michael, Tadayonnejad, Reza, Bari, Ausaf A, and Feusner, Jamie D
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Psychology ,Health Sciences ,Human Society ,Clinical Trials and Supportive Activities ,Anorexia ,Clinical Research ,Neurosciences ,Mental Health ,Eating Disorders ,Serious Mental Illness ,Brain Disorders ,Assistive Technology ,Rehabilitation ,Bioengineering ,Evaluation of treatments and therapeutic interventions ,6.6 Psychological and behavioural ,Anorexia Nervosa ,Humans ,Neurosurgery ,Transcranial Direct Current Stimulation ,Transcranial Magnetic Stimulation ,Treatment Outcome ,Medical and Health Sciences ,Studies in Human Society ,Psychology and Cognitive Sciences ,Clinical Psychology ,Health sciences ,Human society - Abstract
As current psychosocial and pharmacological interventions show limited efficacy in the treatment of anorexia nervosa (AN), interest in the potential value of neurosurgical intervention and neuromodulation in managing severe and enduring illness has grown. We conducted a systematic review of 20 trials of neurosurgical and neuromodulatory treatments for AN, including neurosurgical ablation, deep brain stimulation (DBS), repetitive transcranial magnetic stimulation (rTMS), and transcranial direct current stimulation (tDCS). Overall, there is evidence to support the role of stereotactic ablation and DBS in the treatment of AN. In contrast, results for rTMS and tDCS have been modest and generally more mixed. Neurosurgical treatment may offer important new avenues for the treatment of AN. Additional randomized clinical trials with comparable patient populations will be needed, in which change in affective, cognitive, and perceptual symptom phenomena, and interrogation of targeted circuits, pre- and post-intervention, are carefully documented.
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- 2022
6. Neurocircuit dynamics of arbitration between decision-making strategies across obsessive-compulsive and related disorders
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Seok, Darsol, Tadayonnejad, Reza, Wong, Wan-wa, O'Neill, Joseph, Cockburn, Jeff, Bari, Ausaf A, O'Doherty, John P, and Feusner, Jamie D
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Biological Psychology ,Psychology ,Brain Disorders ,Serious Mental Illness ,Behavioral and Social Science ,Mental Health ,Clinical Research ,Anxiety Disorders ,Neurosciences ,Aetiology ,2.1 Biological and endogenous factors ,Mental health ,Body Dysmorphic Disorders ,Humans ,Negotiating ,Obsessive-Compulsive Disorder ,Putamen ,Obsessive-compulsive disorder ,Body dysmorphic disorder ,Habitual decision-making ,Arbitration circuit ,Dynamic effective connectivity ,Biological psychology ,Clinical and health psychology - Abstract
Obsessions and compulsions are central components of obsessive-compulsive disorder (OCD) and obsessive-compulsive related disorders such as body dysmorphic disorder (BDD). Compulsive behaviours may result from an imbalance of habitual and goal-directed decision-making strategies. The relationship between these symptoms and the neural circuitry underlying habitual and goal-directed decision-making, and the arbitration between these strategies, remains unknown. This study examined resting state effective connectivity between nodes of these systems in two cohorts with obsessions and compulsions, each compared with their own corresponding healthy controls: OCD (nOCD = 43; nhealthy = 24) and BDD (nBDD = 21; nhealthy = 16). In individuals with OCD, the left ventrolateral prefrontal cortex, a node of the arbitration system, exhibited more inhibitory causal influence over the left posterolateral putamen, a node of the habitual system, compared with controls. Inhibitory causal influence in this connection showed a trend for a similar pattern in individuals with BDD compared with controls. Those with stronger negative connectivity had lower obsession and compulsion severity in both those with OCD and those with BDD. These relationships were not evident within the habitual or goal-directed circuits, nor were they associated with depressive or anxious symptomatology. These results suggest that abnormalities in the arbitration system may represent a shared neural phenotype across these two related disorders that is specific to obsessive-compulsive symptoms. In addition to nosological implications, these results identify potential targets for novel, circuit-specific treatments.
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- 2022
7. Mesolimbic Neurobehavioral Mechanisms of Reward Motivation in Anorexia Nervosa: A Multimodal Imaging Study
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Tadayonnejad, Reza, Majid, DS-Adnan, Tsolaki, Evangelia, Rane, Riddhi, Wang, Huan, Moody, Teena D, Pauli, Wolfgang M, Pouratian, Nader, Bari, Ausaf A, Murray, Stuart B, O'Doherty, John P, and Feusner, Jamie D
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Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Behavioral and Social Science ,Anorexia ,Neurosciences ,Biomedical Imaging ,Mental Health ,Eating Disorders ,Brain Disorders ,Serious Mental Illness ,Basic Behavioral and Social Science ,anorexia nervosa ,fMRI ,DTI ,reward motivation ,mesolimbic circuit ,ventral tegmental area ,nucleus accumbens ,bed nucleus of the stria terminalis ,Clinical Sciences ,Public Health and Health Services ,Psychology ,Clinical sciences - Abstract
Diminished motivation to pursue and obtain primary and secondary rewards has been demonstrated in anorexia nervosa (AN). However, the neurobehavioral mechanisms underlying the behavioral activation component of aberrant reward motivation remains incompletely understood. This work aims to explore this underexplored facet of reward motivation in AN. We recruited female adolescents with AN, restricting type (n = 32) and a healthy control group (n = 28). All participants underwent functional magnetic resonance imaging (fMRI) while performing a monetary reward task. Diffusion MRI data was also collected to examine the reward motivation circuit's structural connectivity. Behavioral results demonstrated slower speed of reward-seeking behavior in those with AN compared with controls. Accompanying this was lower functional connectivity and reduced white matter structural integrity of the connection between the ventral tegmental area/substantia nigra pars compacta and the nucleus accumbens within the mesolimbic circuit. Further, there was evidence of neurobehavioral decoupling in AN between reward-seeking behavior and mesolimbic regional activation and functional connectivity. Aberrant activity of the bed nucleus of the stria terminalis (BNST) and its connectivity with the mesolimbic system was also evident in AN during the reward motivation period. Our findings suggest functional and structural dysconnectivity within a mesolimbic reward circuit, neurofunctional decoupling from reward-seeking behavior, and abnormal BNST function and circuit interaction with the mesolimbic system. These results show behavioral indicators of aberrant reward motivation in AN, particularly in its activational component. This is mediated neuronally by mesolimbic reward circuit functional and structural dysconnectivity as well as neurobehavioral decoupling. Based on these findings, we suggest a novel circuit-based mechanism of impaired reward processing in AN, with the potential for translation to developing more targeted and effective treatments in this difficult-to-treat psychiatric condition.
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- 2022
8. Self-focused brain predictors of cognitive behavioral therapy response in a transdiagnostic sample
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Fang, Angela, Baran, Bengi, Feusner, Jamie D., Phan, K. Luan, Beatty, Clare C., Crane, Jessica, Jacoby, Ryan J., Manoach, Dara S., and Wilhelm, Sabine
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- 2024
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9. Effects of visual attention modulation on dynamic functional connectivity during own-face viewing in body dysmorphic disorder
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Wong, Wan-wa, Cabral, Joana, Rane, Riddhi, Ly, Ronald, Kringelbach, Morten L, and Feusner, Jamie D
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Biological Psychology ,Psychology ,Behavioral and Social Science ,Eye Disease and Disorders of Vision ,Mental Health ,Neurosciences ,Basic Behavioral and Social Science ,Clinical Research ,Serious Mental Illness ,Mental health ,Adult ,Body Dysmorphic Disorders ,Brain ,Face ,Frontal Lobe ,Humans ,Magnetic Resonance Imaging ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Biological psychology - Abstract
Body dysmorphic disorder (BDD) is characterized by preoccupations with misperceptions of one's physical appearance. Previous neuroimaging studies in BDD have yet to examine dynamic functional connectivity (FC) patterns between brain areas, necessary to capture changes in activity in response to stimuli and task conditions. We used Leading Eigenvector Dynamics Analysis to examine whole-brain dynamic FC from fMRI data during an own-face viewing task in 29 unmedicated adults with BDD with facial concerns and 30 healthy controls. The task involved two parts: (1) unconstrained, naturalistic viewing and (2) holding visual attention in the center of the image, to reduce scanning and fixation on perceived facial flaws. An FC state consisting of bilateral medial orbitofrontal cortex regions occurred significantly less often during the visual attention condition and afterward during the unconstrained face viewing in BDD participants, compared to the first unconstrained face viewing, a pattern that differed from controls. Moreover, the probability of this state during the second unconstrained face viewing was associated with severity of obsessions and compulsions and degree of poor insight in BDD, suggesting its clinical significance. These findings have implications for understanding the pathophysiology of own-face viewing in BDD and how it is affected by modification of viewing patterns, which may have implications for novel perceptual retraining treatment designs.
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- 2021
10. FMRI hemodynamic response function (HRF) as a novel marker of brain function: applications for understanding obsessive-compulsive disorder pathology and treatment response
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Rangaprakash, D, Tadayonnejad, Reza, Deshpande, Gopikrishna, O’Neill, Joseph, and Feusner, Jamie D
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Biological Psychology ,Psychology ,Serious Mental Illness ,Clinical Research ,Mental Health ,Neurosciences ,Brain Disorders ,Neurological ,Mental health ,Adult ,Brain ,Brain Mapping ,Hemodynamics ,Humans ,Magnetic Resonance Imaging ,Neurovascular Coupling ,Obsessive-Compulsive Disorder ,Functional magnetic resonance imaging ,fMRI ,Hemodynamic response function ,HRF ,Obsessive-compulsive disorder ,OCD ,Cognitive-behavioral therapy ,CBT ,Machine learning ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Experimental Psychology ,Biomedical and clinical sciences ,Health sciences - Abstract
The hemodynamic response function (HRF) represents the transfer function linking neural activity with the functional MRI (fMRI) signal, modeling neurovascular coupling. Since HRF is influenced by non-neural factors, to date it has largely been considered as a confound or has been ignored in many analyses. However, underlying biophysics suggests that the HRF may contain meaningful correlates of neural activity, which might be unavailable through conventional fMRI metrics. Here, we estimated the HRF by performing deconvolution on resting-state fMRI data from a longitudinal sample of 25 healthy controls scanned twice and 44 adults with obsessive-compulsive disorder (OCD) before and after 4-weeks of intensive cognitive-behavioral therapy (CBT). HRF response height, time-to-peak and full-width at half-maximum (FWHM) in OCD were abnormal before treatment and normalized after treatment in regions including the caudate. Pre-treatment HRF predicted treatment outcome (OCD symptom reduction) with 86.4% accuracy, using machine learning. Pre-treatment HRF response height in the caudate head and time-to-peak in the caudate tail were top-predictors of treatment response. Time-to-peak in the caudate tail, a region not typically identified in OCD studies using conventional fMRI activation or connectivity measures, may carry novel importance. Additionally, pre-treatment response height in caudate head predicted post-treatment OCD severity (R = -0.48, P = 0.001), and was associated with treatment-related OCD severity changes (R = -0.44, P = 0.0028), underscoring its relevance. With HRF being a reliable marker sensitive to brain function, OCD pathology, and intervention-related changes, these results could guide future studies towards novel discoveries not possible through conventional fMRI approaches like standard BOLD activation or connectivity.
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- 2021
11. Factors associated with delay to video-EEG in dissociative seizures
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Kerr, Wesley T, Zhang, Xingruo, Hill, Chloe E, Janio, Emily A, Chau, Andrea M, Braesch, Chelsea T, Le, Justine M, Hori, Jessica M, Patel, Akash B, Allas, Corinne H, Karimi, Amir H, Dubey, Ishita, Sreenivasan, Siddhika S, Gallardo, Norma L, Bauirjan, Janar, Hwang, Eric S, Davis, Emily C, D'Ambrosio, Shannon R, Al Banna, Mona, Cho, Andrew Y, Dewar, Sandra R, Engel, Jerome, Feusner, Jamie D, and Stern, John M
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Biomedical and Clinical Sciences ,Neurosciences ,Clinical Sciences ,Epilepsy ,Clinical Research ,Neurodegenerative ,Brain Disorders ,Neurological ,Good Health and Well Being ,Adult ,Child ,Electroencephalography ,Humans ,Prospective Studies ,Quality of Life ,Retrospective Studies ,Seizures ,Functional seizures ,Psychogenic nonepileptic seizures ,Psychogenic nonepileptic attack disorder ,(PNEA ,PNEAD) ,Healthcare disparities ,Diagnostic delays ,Psychology ,Neurology & Neurosurgery ,Clinical sciences ,Biological psychology - Abstract
PurposeWhile certain clinical factors suggest a diagnosis of dissociative seizures (DS), otherwise known as functional or psychogenic nonepileptic seizures (PNES), ictal video-electroencephalography monitoring (VEM) is the gold standard for diagnosis. Diagnostic delays were associated with worse quality of life and more seizures, even after treatment. To understand why diagnoses were delayed, we evaluated which factors were associated with delay to VEM.MethodsUsing data from 341 consecutive patients with VEM-documented dissociative seizures, we used multivariate log-normal regression with recursive feature elimination (RFE) and multiple imputation of some missing data to evaluate which of 76 clinical factors were associated with time from first dissociative seizure to VEM.ResultsThe mean delay to VEM was 8.4 years (median 3 years, IQR 1-10 years). In the RFE multivariate model, the factors associated with longer delay to VEM included more past antiseizure medications (0.19 log-years/medication, standard error (SE) 0.05), more medications for other medical conditions (0.06 log-years/medication, SE 0.03), history of physical abuse (0.75 log-years, SE 0.27), and more seizure types (0.36 log-years/type, SE 0.11). Factors associated with shorter delay included active employment or student status (-1.05 log-years, SE 0.21) and higher seizure frequency (0.14 log-years/log[seizure/month], SE 0.06).ConclusionsPatients with greater medical and seizure complexity had longer delays. Delays in multiple domains of healthcare can be common for victims of physical abuse. Unemployed and non-student patients may have had more barriers to access VEM. These results support earlier referral of complex cases to a comprehensive epilepsy center.
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- 2021
12. Epilepsy, dissociative seizures, and mixed: Associations with time to video-EEG
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Kerr, Wesley T, Zhang, Xingruo, Hill, Chloe E, Janio, Emily A, Chau, Andrea M, Braesch, Chelsea T, Le, Justine M, Hori, Jessica M, Patel, Akash B, Allas, Corinne H, Karimi, Amir H, Dubey, Ishita, Sreenivasan, Siddhika S, Gallardo, Norma L, Bauirjan, Janar, Hwang, Eric S, Davis, Emily C, D'Ambrosio, Shannon R, Al Banna, Mona, Cho, Andrew Y, Dewar, Sandra R, Engel, Jerome, Feusner, Jamie D, and Stern, John M
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Biomedical and Clinical Sciences ,Neurosciences ,Clinical Sciences ,Brain Disorders ,Epilepsy ,Clinical Research ,Mental Health ,Neurodegenerative ,2.1 Biological and endogenous factors ,Aetiology ,Neurological ,Conversion Disorder ,Electroencephalography ,Humans ,Retrospective Studies ,Seizures ,Functional seizures ,Drug resistant epilepsy ,Healthcare triage ,Psychogenic nonepileptic seizures (PNES ,PNEA) ,Psychogenic nonepileptic seizures ,Psychology ,Neurology & Neurosurgery ,Clinical sciences ,Biological psychology - Abstract
PurposeVideo-electroencephalographic monitoring (VEM) is a core component to the diagnosis and evaluation of epilepsy and dissociative seizures (DS)-also known as functional or psychogenic seizures-but VEM evaluation often occurs later than recommended. To understand why delays occur, we compared how patient-reported clinical factors were associated with time from first seizure to VEM (TVEM) in patients with epilepsy, DS or mixed.MethodsWe acquired data from 1245 consecutive patients with epilepsy, VEM-documented DS or mixed epilepsy and DS. We used multivariate log-normal regression with recursive feature elimination (RFE) to evaluate which of 76 clinical factors interacting with patients' diagnoses were associated with TVEM.ResultsThe mean and median TVEM were 14.6 years and 10 years, respectively (IQR 3-23 years). In the multivariate RFE model, the factors associated with longer TVEM in all patients included unemployment and not student status, more antiseizure medications (current and past), concussion, and ictal behavior suggestive of temporal lobe epilepsy. Average TVEM was shorter for DS than epilepsy, particularly for patients with depression, anxiety, migraines, and eye closure. Average TVEM was longer specifically for patients with DS taking more medications, more seizure types, non-metastatic cancer, and with other psychiatric comorbidities.ConclusionsIn all patients with seizures, trials of numerous antiseizure medications, unemployment and non-student status was associated with longer TVEM. These associations highlight a disconnect between International League Against Epilepsy practice parameters and observed referral patterns in epilepsy. In patients with dissociative seizures, some but not all factors classically associated with DS reduced TVEM.
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- 2021
13. Reliability of additional reported seizure manifestations to identify dissociative seizures.
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Kerr, Wesley T, Zhang, Xingruo, Janio, Emily A, Karimi, Amir H, Allas, Corinne H, Dubey, Ishita, Sreenivasan, Siddhika S, Bauirjan, Janar, D'Ambrosio, Shannon R, Al Banna, Mona, Cho, Andrew Y, Engel, Jerome, Cohen, Mark S, Feusner, Jamie D, and Stern, John M
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Humans ,Seizures ,Electroencephalography ,Retrospective Studies ,Reproducibility of Results ,Conversion Disorder ,Functional seizures ,Psychogenic nonepileptic seizures ,Semiology ,Symptomatogenic zone ,Neurosciences ,Epilepsy ,Intellectual and Developmental Disabilities (IDD) ,Neurodegenerative ,Brain Disorders ,Clinical Sciences ,Neurology & Neurosurgery - Abstract
PurposeDescriptions of seizure manifestations (SM), or semiology, can help localize the symptomatogenic zone and subsequently included brain regions involved in epileptic seizures, as well as identify patients with dissociative seizures (DS). Patients and witnesses are not trained observers, so these descriptions may vary from expert review of seizure video recordings of seizures. To better understand how reported factors can help identify patients with DS or epileptic seizures (ES), we evaluated the associations between more than 30 SMs and diagnosis using standardized interviews.MethodsBased on patient- and observer-reported data from 490 patients with diagnoses documented by video-electoencephalography, we compared the rate of each SM in five mutually exclusive groups: epileptic seizures (ES), DS, physiologic seizure-like events (PSLE), mixed DS and ES, and inconclusive testing.ResultsIn addition to SMs that we described in a prior manuscript, the following were associated with DS: light triggers, emotional stress trigger, pre-ictal and post-ictal headache, post-ictal muscle soreness, and ictal sensory symptoms. The following were associated with ES: triggered by missing medication, aura of déjà vu, and leftward eye deviation. There were numerous manifestations separately associated with mixed ES and DS.ConclusionsReported SM can help identify patients with DS, but no manifestation is pathognomonic for either ES or DS. Patients with mixed ES and DS reported factors divergent from both ES-alone and DS-alone.
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- 2021
14. White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa
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Tadayonnejad, Reza, Pizzagalli, Fabrizio, Murray, Stuart B, Pauli, Wolfgang M, Conde, Geena, Bari, Ausaf A, Strober, Michael, O’Doherty, John P, and Feusner, Jamie D
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Biological Psychology ,Psychology ,Eating Disorders ,Anorexia ,Brain Disorders ,Serious Mental Illness ,Mental Health ,Pediatric ,Neurosciences ,Behavioral and Social Science ,Adolescent ,Adult ,Anorexia Nervosa ,Brain ,Compulsive Behavior ,Decision Making ,Diffusion Tensor Imaging ,Female ,Habits ,Humans ,Male ,White Matter ,Young Adult - Abstract
Anorexia nervosa (AN) is a difficult to treat, pernicious psychiatric disorder that has been linked to decision-making abnormalities. We examined the structural characteristics of habitual and goal-directed decision-making circuits and their connecting white matter tracts in 32 AN and 43 healthy controls across two independent data sets of adults and adolescents as an explanatory sub-study. Total bilateral premotor/supplementary motor area-putamen tracts in the habit circuit had a significantly higher volume in adults with AN, relative to controls. Positive correlations were found between both the number of tracts and white matter volume (WMV) in the habit circuit, and the severity of ritualistic/compulsive behaviors in adults and adolescents with AN. Moreover, we found a significant influence of the habit circuit WMV on AN ritualistic/compulsive symptom severity, depending on the preoccupations symptom severity levels. These findings suggest that AN is associated with white matter plasticity alterations in the habit circuit. The association between characteristics of habit circuit white matter tracts and AN behavioral symptoms provides support for a circuit based neurobiological model of AN, and identifies the habit circuit as a focus for further investigation to aid in development of novel and more effective treatments based on brain-behavior relationships.
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- 2021
15. Cytoarchitectonically Defined Volumes of Early Extrastriate Visual Cortex in Unmedicated Adults With Body Dysmorphic Disorder
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Feusner, Jamie D., Kurth, Florian, Luders, Eileen, Ly, Ronald, and Wong, Wan-wa
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- 2023
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16. Amygdala subfield and prefrontal cortex abnormalities in patients with functional seizures
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Nasrullah, Nilab, Kerr, Wesley T., Stern, John M., Wang, Yanlu, Tatekawa, Hiroyuki, Lee, John K., Karimi, Amir H., Sreenivasan, Siddhika S., Engel, Jerome, Jr, Eliashiv, Dawn E., Feusner, Jamie D., Salamon, Noriko, and Savic, Ivanka
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- 2023
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17. Correction: The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium
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Bruin, Willem B., Abe, Yoshinari, Alonso, Pino, Anticevic, Alan, Backhausen, Lea L., Balachander, Srinivas, Bargallo, Nuria, Batistuzzo, Marcelo C., Benedetti, Francesco, Bertolin Triquell, Sara, Brem, Silvia, Calesella, Federico, Couto, Beatriz, Denys, Damiaan A. J. P., Echevarria, Marco A. N., Eng, Goi Khia, Ferreira, Sónia, Feusner, Jamie D., Grazioplene, Rachael G., Gruner, Patricia, Guo, Joyce Y., Hagen, Kristen, Hansen, Bjarne, Hirano, Yoshiyuki, Hoexter, Marcelo Q., Jahanshad, Neda, Jaspers-Fayer, Fern, Kasprzak, Selina, Kim, Minah, Koch, Kathrin, Bin Kwak, Yoo, Kwon, Jun Soo, Lazaro, Luisa, Li, Chiang-Shan R., Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Menchon, Jose M., Moreira, Pedro S., Morgado, Pedro, Nakagawa, Akiko, Nakao, Tomohiro, Narayanaswamy, Janardhanan C., Nurmi, Erika L., Zorrilla, Jose C. Pariente, Piacentini, John, Picó-Pérez, Maria, Piras, Fabrizio, Piras, Federica, Pittenger, Christopher, Reddy, Janardhan Y. C., Rodriguez-Manrique, Daniela, Sakai, Yuki, Shimizu, Eiji, Shivakumar, Venkataram, Simpson, Blair H., Soriano-Mas, Carles, Sousa, Nuno, Spalletta, Gianfranco, Stern, Emily R., Evelyn Stewart, S., Szeszko, Philip R., Tang, Jinsong, Thomopoulos, Sophia I., Thorsen, Anders L., Yoshida, Tokiko, Tomiyama, Hirofumi, Vai, Benedetta, Veer, Ilya M., Venkatasubramanian, Ganesan, Vetter, Nora C., Vriend, Chris, Walitza, Susanne, Waller, Lea, Wang, Zhen, Watanabe, Anri, Wolff, Nicole, Yun, Je-Yeon, Zhao, Qing, van Leeuwen, Wieke A., van Marle, Hein J. F., van de Mortel, Laurens A., van der Straten, Anouk, van der Werf, Ysbrand D., Thompson, Paul M., Stein, Dan J., van den Heuvel, Odile A., and van Wingen, Guido A.
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- 2023
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18. Sequential multi-locus transcranial magnetic stimulation for treatment of obsessive-compulsive disorder with comorbid major depression: A case series.
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Tadayonnejad, Reza, Wilson, Andrew C, Corlier, Juliana, Lee, Jonathan C, Ginder, Nathaniel D, Levitt, Jennifer G, Wilke, Scott A, Marder, Katharine G, Krantz, David, Bari, Ausaf A, Feusner, Jamie D, Pouratian, Nader, and Leuchter, Andrew F
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Medical and Health Sciences ,Neurology & Neurosurgery - Published
- 2020
19. Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters.
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Bruin, Willem B, Taylor, Luke, Thomas, Rajat M, Shock, Jonathan P, Zhutovsky, Paul, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie H, Anticevic, Alan, Arnold, Paul D, Assogna, Francesca, Benedetti, Francesco, Beucke, Jan C, Boedhoe, Premika SW, Bollettini, Irene, Bose, Anushree, Brem, Silvia, Brennan, Brian P, Buitelaar, Jan K, Calvo, Rosa, Cheng, Yuqi, Cho, Kang Ik K, Dallaspezia, Sara, Denys, Damiaan, Ely, Benjamin A, Feusner, Jamie D, Fitzgerald, Kate D, Fouche, Jean-Paul, Fridgeirsson, Egill A, Gruner, Patricia, Gürsel, Deniz A, Hauser, Tobias U, Hirano, Yoshiyuki, Hoexter, Marcelo Q, Hu, Hao, Huyser, Chaim, Ivanov, Iliyan, James, Anthony, Jaspers-Fayer, Fern, Kathmann, Norbert, Kaufmann, Christian, Koch, Kathrin, Kuno, Masaru, Kvale, Gerd, Kwon, Jun Soo, Liu, Yanni, Lochner, Christine, Lázaro, Luisa, Marques, Paulo, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Menchón, José M, Minuzzi, Luciano, Moreira, Pedro S, Morer, Astrid, Morgado, Pedro, Nakagawa, Akiko, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswamy, Janardhanan C, Nurmi, Erika L, O'Neill, Joseph, Pariente, Jose C, Perriello, Chris, Piacentini, John, Piras, Fabrizio, Piras, Federica, Reddy, YC Janardhan, Rus-Oswald, Oana G, Sakai, Yuki, Sato, João R, Schmaal, Lianne, Shimizu, Eiji, Simpson, H Blair, Soreni, Noam, Soriano-Mas, Carles, Spalletta, Gianfranco, Stern, Emily R, Stevens, Michael C, Stewart, S Evelyn, Szeszko, Philip R, Tolin, David F, Venkatasubramanian, Ganesan, Wang, Zhen, Yun, Je-Yeon, van Rooij, Daan, ENIGMA-OCD Working Group, Thompson, Paul M, van den Heuvel, Odile A, Stein, Dan J, and van Wingen, Guido A
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ENIGMA-OCD Working Group ,Clinical Sciences ,Public Health and Health Services ,Psychology - Abstract
No diagnostic biomarkers are available for obsessive-compulsive disorder (OCD). Here, we aimed to identify magnetic resonance imaging (MRI) biomarkers for OCD, using 46 data sets with 2304 OCD patients and 2068 healthy controls from the ENIGMA consortium. We performed machine learning analysis of regional measures of cortical thickness, surface area and subcortical volume and tested classification performance using cross-validation. Classification performance for OCD vs. controls using the complete sample with different classifiers and cross-validation strategies was poor. When models were validated on data from other sites, model performance did not exceed chance-level. In contrast, fair classification performance was achieved when patients were grouped according to their medication status. These results indicate that medication use is associated with substantial differences in brain anatomy that are widely distributed, and indicate that clinical heterogeneity contributes to the poor performance of structural MRI as a disease marker.
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- 2020
20. Right Prefrontal Cortical Thickness Is Associated With Response to Cognitive-Behavioral Therapy in Children With Obsessive-Compulsive Disorder
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Real, Eva, Segalas, Cinto, Morer, Astrid, Brem, Silvia, Ferreira, Sonia, Moreira, Pedro Silva, Hagen, Kristen, Hamatani, Sayo, Takahashi, Jumpei, Yoshida, Tokiko, de Mathis, Maria Alice, Miguel, Euripedes C., Pariente, Jose C., Tang, Jinsong, Bertolín, Sara, Alonso, Pino, Martínez-Zalacaín, Ignacio, Menchón, Jose M., Jimenez-Murcia, Susana, Baker, Justin T., Bargalló, Nuria, Batistuzzo, Marcelo Camargo, Boedhoe, Premika S.W., Brennan, Brian P., Feusner, Jamie D., Fitzgerald, Kate D., Fontaine, Martine, Hansen, Bjarne, Hirano, Yoshiyuki, Hoexter, Marcelo Q., Huyser, Chaim, Jahanshad, Neda, Jaspers-Fayer, Fern, Kuno, Masaru, Kvale, Gerd, Lazaro, Luisa, Machado-Sousa, Mafalda, Marsh, Rachel, Morgado, Pedro, Nakagawa, Akiko, Norman, Luke, Nurmi, Erika L., O’Neill, Joseph, Ortiz, Ana E., Perriello, Chris, Piacentini, John, Picó-Pérez, Maria, Shavitt, Roseli G., Shimizu, Eiji, Simpson, Helen Blair, Stewart, S. Evelyn, Thomopoulos, Sophia I., Thorsen, Anders Lillevik, Walitza, Susanne, Wolters, Lidewij H., Thompson, Paul M., van den Heuvel, Odile A., Stein, Dan J., and Soriano-Mas, Carles
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- 2023
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21. Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups
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Boedhoe, Premika SW, van Rooij, Daan, Hoogman, Martine, Twisk, Jos WR, Schmaal, Lianne, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie H, Anikin, Anatoly, Anticevic, Alan, Arango, Celso, Arnold, Paul D, Asherson, Philip, Assogna, Francesca, Auzias, Guillaume, Banaschewski, Tobias, Baranov, Alexander, Batistuzzo, Marcelo C, Baumeister, Sarah, Baur-Streubel, Ramona, Behrmann, Marlene, Bellgrove, Mark A, Benedetti, Francesco, Beucke, Jan C, Biederman, Joseph, Bollettini, Irene, Bose, Anushree, Bralten, Janita, Bramati, Ivanei E, Brandeis, Daniel, Brem, Silvia, Brennan, Brian P, Busatto, Geraldo F, Calderoni, Sara, Calvo, Anna, Calvo, Rosa, Castellanos, Francisco X, Cercignani, Mara, Chaim-Avancini, Tiffany M, Chantiluke, Kaylita C, Cheng, Yuqi, Cho, Kang Ik K, Christakou, Anastasia, Coghill, David, Conzelmann, Annette, Cubillo, Ana I, Dale, Anders M, Dallaspezia, Sara, Daly, Eileen, Denys, Damiaan, Deruelle, Christine, Di Martino, Adriana, Dinstein, Ilan, Doyle, Alysa E, Durston, Sarah, Earl, Eric A, Ecker, Christine, Ehrlich, Stefan, Ely, Benjamin A, Epstein, Jeffrey N, Ethofer, Thomas, Fair, Damien A, Fallgatter, Andreas J, Faraone, Stephen V, Fedor, Jennifer, Feng, Xin, Feusner, Jamie D, Fitzgerald, Jackie, Fitzgerald, Kate D, Fouche, Jean-Paul, Freitag, Christine M, Fridgeirsson, Egill A, Frodl, Thomas, Gabel, Matt C, Gallagher, Louise, Gogberashvili, Tinatin, Gori, Ilaria, Gruner, Patricia, Gürsel, Deniz A, Haar, Shlomi, Haavik, Jan, Hall, Geoffrey B, Harrison, Neil A, Hartman, Catharina A, Heslenfeld, Dirk J, Hirano, Yoshiyuki, Hoekstra, Pieter J, Hoexter, Marcelo Q, Hohmann, Sarah, Høvik, Marie F, Hu, Hao, Huyser, Chaim, Jahanshad, Neda, Jalbrzikowski, Maria, James, Anthony, Janssen, Joost, Jaspers-Fayer, Fern, Jernigan, Terry L, Kapilushniy, Dmitry, and Kardatzki, Bernd
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Attention Deficit Hyperactivity Disorder (ADHD) ,Behavioral and Social Science ,Clinical Research ,Mental Health ,Neurosciences ,Pediatric ,Autism ,Intellectual and Developmental Disabilities (IDD) ,Brain Disorders ,2.1 Biological and endogenous factors ,2.3 Psychological ,social and economic factors ,Aetiology ,Mental health ,Neurological ,Adolescent ,Adult ,Attention Deficit Disorder with Hyperactivity ,Autism Spectrum Disorder ,Cerebrum ,Child ,Female ,Human Development ,Humans ,Male ,Neuroimaging ,Obsessive-Compulsive Disorder ,Organ Size ,Psychopathology ,Research Report ,Systems Analysis ,ENIGMA ADHD working group ,ENIGMA ASD working group ,ENIGMA OCD working group ,Attention Deficit Hyperactivity Disorder ,ENIGMA ,Structural MRI ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry - Abstract
ObjectiveAttention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD) are common neurodevelopmental disorders that frequently co-occur. The authors sought to directly compare these disorders using structural brain imaging data from ENIGMA consortium data.MethodsStructural T1-weighted whole-brain MRI data from healthy control subjects (N=5,827) and from patients with ADHD (N=2,271), ASD (N=1,777), and OCD (N=2,323) from 151 cohorts worldwide were analyzed using standardized processing protocols. The authors examined subcortical volume, cortical thickness, and cortical surface area differences within a mega-analytical framework, pooling measures extracted from each cohort. Analyses were performed separately for children, adolescents, and adults, using linear mixed-effects models adjusting for age, sex, and site (and intracranial volume for subcortical and surface area measures).ResultsNo shared differences were found among all three disorders, and shared differences between any two disorders did not survive correction for multiple comparisons. Children with ADHD compared with those with OCD had smaller hippocampal volumes, possibly influenced by IQ. Children and adolescents with ADHD also had smaller intracranial volume than control subjects and those with OCD or ASD. Adults with ASD showed thicker frontal cortices compared with adult control subjects and other clinical groups. No OCD-specific differences were observed across different age groups and surface area differences among all disorders in childhood and adulthood.ConclusionsThe study findings suggest robust but subtle differences across different age groups among ADHD, ASD, and OCD. ADHD-specific intracranial volume and hippocampal differences in children and adolescents, and ASD-specific cortical thickness differences in the frontal cortex in adults, support previous work emphasizing structural brain differences in these disorders.
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- 2020
22. Corrigendum
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Yun, Je-Yeon, Boedhoe, Premika SW, Vriend, Chris, Jahanshad, Neda, Abe, Yoshinari, Ameis, Stephanie H, Anticevic, Alan, Arnold, Paul D, Batistuzzo, Marcelo C, Benedetti, Francesco, Beucke, Jan C, Bollettini, Irene, Bose, Anushree, Brem, Silvia, Calvo, Anna, Cheng, Yuqi, Cho, Kang Ik K, Ciullo, Valentina, Dallaspezia, Sara, Denys, Damiaan, Feusner, Jamie D, Fouche, Jean-Paul, Gimenez, Monica, Gruner, Patricia, Hibar, Derrek P, Hoexter, Marcelo Q, Hu, Hao, Huyser, Chaim, Ikari, Keisuke, Kathmann, Norbert, Kaufmann, Christian, Koch, Kathrin, Lazaro, Luisa, Lochner, Christine, Marques, Paulo, Marsh, Rachel, Martinez-Zalacain, Ignacio, Mataix-Cols, David, Menchon, Jose M, Minuzzi, Luciano, Morgado, Pedro, Moreira, Pedro, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswamy, Janardhanan C, Nurmi, Erika L, O'Neill, Joseph, Piacentini, John, Piras, Fabrizio, Piras, Federica, Reddy, YC Janardhan, Sato, Joao R, Simpson, H Blair, Soreni, Noam, Soriano-Mas, Carles, Spalletta, Gianfranco, Stevens, Michael C, Szeszko, Philip R, Tolin, David F, Venkatasubramanian, Ganesan, Walitza, Susanne, Wang, Zhen, van Wingen, Guido A, Xu, Jian, Xu, Xiufeng, Zhao, Qing, Thompson, Paul M, Stein, Dan J, van den Heuvel, Odile A, and Kwon, Jun Soo
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Biomedical and Clinical Sciences ,Health Sciences ,Psychology ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery ,Biomedical and clinical sciences ,Health sciences - Published
- 2020
23. Brain structural covariance networks in obsessive-compulsive disorder: a graph analysis from the ENIGMA Consortium
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Yun, Je-Yeon, Boedhoe, Premika SW, Vriend, Chris, Jahanshad, Neda, Abe, Yoshinari, Ameis, Stephanie H, Anticevic, Alan, Arnold, Paul D, Batistuzzo, Marcelo C, Benedetti, Francesco, Beucke, Jan C, Bollettini, Irene, Bose, Anushree, Brem, Silvia, Calvo, Anna, Cheng, Yuqi, Cho, Kang Ik K, Ciullo, Valentina, Dallaspezia, Sara, Denys, Damiaan, Feusner, Jamie D, Fouche, Jean-Paul, Giménez, Mònica, Gruner, Patricia, Hibar, Derrek P, Hoexter, Marcelo Q, Hu, Hao, Huyser, Chaim, Ikari, Keisuke, Kathmann, Norbert, Kaufmann, Christian, Koch, Kathrin, Lazaro, Luisa, Lochner, Christine, Marques, Paulo, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Menchón, José M, Minuzzi, Luciano, Morgado, Pedro, Moreira, Pedro, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswamy, Janardhanan C, Nurmi, Erika L, O’Neill, Joseph, Piacentini, John, Piras, Fabrizio, Piras, Federica, Reddy, YC Janardhan, Sato, Joao R, Simpson, H Blair, Soreni, Noam, Soriano-Mas, Carles, Spalletta, Gianfranco, Stevens, Michael C, Szeszko, Philip R, Tolin, David F, Venkatasubramanian, Ganesan, Walitza, Susanne, Wang, Zhen, van Wingen, Guido A, Xu, Jian, Xu, Xiufeng, Zhao, Qing, van den Heuvel, Odile3 A, Stein, Dan J, Thompson, Paul M, Ik, Kang, and Cho, K
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Mental Health ,Brain Disorders ,Serious Mental Illness ,Clinical Research ,Neurosciences ,Neurological ,Mental health ,Adult ,Brain ,Cerebral Cortex ,Female ,Humans ,Image Processing ,Computer-Assisted ,Magnetic Resonance Imaging ,Male ,Neural Pathways ,Obsessive-Compulsive Disorder ,brain structural covariance network ,graph theory ,obsessive-compulsive disorder ,pharmacotherapy ,illness duration ,ENIGMA-OCD working group ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery - Abstract
Brain structural covariance networks reflect covariation in morphology of different brain areas and are thought to reflect common trajectories in brain development and maturation. Large-scale investigation of structural covariance networks in obsessive-compulsive disorder (OCD) may provide clues to the pathophysiology of this neurodevelopmental disorder. Using T1-weighted MRI scans acquired from 1616 individuals with OCD and 1463 healthy controls across 37 datasets participating in the ENIGMA-OCD Working Group, we calculated intra-individual brain structural covariance networks (using the bilaterally-averaged values of 33 cortical surface areas, 33 cortical thickness values, and six subcortical volumes), in which edge weights were proportional to the similarity between two brain morphological features in terms of deviation from healthy controls (i.e. z-score transformed). Global networks were characterized using measures of network segregation (clustering and modularity), network integration (global efficiency), and their balance (small-worldness), and their community membership was assessed. Hub profiling of regional networks was undertaken using measures of betweenness, closeness, and eigenvector centrality. Individually calculated network measures were integrated across the 37 datasets using a meta-analytical approach. These network measures were summated across the network density range of K = 0.10-0.25 per participant, and were integrated across the 37 datasets using a meta-analytical approach. Compared with healthy controls, at a global level, the structural covariance networks of OCD showed lower clustering (P
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- 2020
24. Predicting Empathy From Resting State Brain Connectivity: A Multivariate Approach
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Christov-Moore, Leonardo, Reggente, Nicco, Douglas, Pamela K, Feusner, Jamie D, and Iacoboni, Marco
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Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Biological Sciences ,Clinical Sciences ,Neurosciences ,Clinical Research ,empathy ,empathic concern ,fMRI ,resting state ,connectivity ,machine learning ,experience sharing ,mirroring ,Psychology ,Cognitive Sciences ,Biochemistry and cell biology ,Clinical sciences - Abstract
Recent task fMRI studies suggest that individual differences in trait empathy and empathic concern are mediated by patterns of connectivity between self-other resonance and top-down control networks that are stable across task demands. An untested implication of this hypothesis is that these stable patterns of connectivity should be visible even in the absence of empathy tasks. Using machine learning, we demonstrate that patterns of resting state fMRI connectivity (i.e. the degree of synchronous BOLD activity across multiple cortical areas in the absence of explicit task demands) of resonance and control networks predict trait empathic concern (n = 58). Empathic concern was also predicted by connectivity patterns within the somatomotor network. These findings further support the role of resonance-control network interactions and of somatomotor function in our vicariously driven concern for others. Furthermore, a practical implication of these results is that it is possible to assess empathic predispositions in individuals without needing to perform conventional empathy assessments.
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- 2020
25. Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group
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Walton, Esther, Bernardoni, Fabio, Batury, Victoria-Luise, Bahnsen, Klaas, Larivière, Sara, Abbate-Daga, Giovanni, Andres-Perpiña, Susana, Bang, Lasse, Bischoff-Grethe, Amanda, Brooks, Samantha J., Campbell, Iain C., Cascino, Giammarco, Castro-Fornieles, Josefina, Collantoni, Enrico, D’Agata, Federico, Dahmen, Brigitte, Danner, Unna N., Favaro, Angela, Feusner, Jamie D., Frank, Guido K.W., Friederich, Hans-Christoph, Graner, John L., Herpertz-Dahlmann, Beate, Hess, Andreas, Horndasch, Stefanie, Kaplan, Allan S., Kaufmann, Lisa-Katrin, Kaye, Walter H., Khalsa, Sahib S., LaBar, Kevin S., Lavagnino, Luca, Lazaro, Luisa, Manara, Renzo, Miles, Amy E., Milos, Gabriella F., Monteleone, Alessio Maria, Monteleone, Palmiero, Mwangi, Benson, O’Daly, Owen, Pariente, Jose, Roesch, Julie, Schmidt, Ulrike H., Seitz, Jochen, Shott, Megan E., Simon, Joe J., Smeets, Paul A.M., Tamnes, Christian K., Tenconi, Elena, Thomopoulos, Sophia I., van Elburg, Annemarie A., Voineskos, Aristotle N., von Polier, Georg G., Wierenga, Christina E., Zucker, Nancy L., Jahanshad, Neda, King, Joseph A., Thompson, Paul M., Berner, Laura A., and Ehrlich, Stefan
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- 2022
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26. Sex differences in own and other body perception
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Burke, Sarah M, Majid, DS Adnan, Manzouri, Amir H, Moody, Teena, Feusner, Jamie D, and Savic, Ivanka
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Brain Disorders ,Behavioral and Social Science ,Basic Behavioral and Social Science ,Neurosciences ,Mental Health ,Clinical Research ,Eating Disorders ,2.3 Psychological ,social and economic factors ,Aetiology ,1.2 Psychological and socioeconomic processes ,Underpinning research ,Mental health ,Adult ,Attention ,Brain Mapping ,Cerebral Cortex ,Female ,Humans ,Magnetic Resonance Imaging ,Male ,Neostriatum ,Reward ,Self Concept ,Sex Characteristics ,Sex Factors ,Social Perception ,Visual Perception ,Young Adult ,body perception ,fMRI ,other body ,own body ,sex differences ,Cognitive Sciences ,Experimental Psychology - Abstract
Own body perception, and differentiating and comparing one's body to another person's body, are common cognitive functions that have relevance for self-identity and social interactions. In several psychiatric conditions, including anorexia nervosa, body dysmorphic disorder, gender dysphoria, and autism spectrum disorder, self and own body perception, as well as aspects of social communication are disturbed. Despite most of these conditions having skewed prevalence sex ratios, little is known about whether the neural basis of own body perception differs between the sexes. We addressed this question by investigating brain activation using functional magnetic resonance imaging during a Body Perception task in 15 male and 15 female healthy participants. Participants viewed their own body, bodies of same-sex, or opposite-sex other people, and rated the degree that they appeared like themselves. We found that men and women did not differ in the pattern of brain activation during own body perception compared to a scrambled control image. However, when viewing images of other bodies of same-sex or opposite-sex, men showed significantly stronger activations in attention-related and reward-related brain regions, whereas women engaged stronger activations in striatal, medial-prefrontal, and insular cortices, when viewing the own body compared to other images of the opposite sex. It is possible that other body images, particularly of the opposite sex, may be of greater salience for men, whereas images of own bodies may be more salient for women. These observations provide tentative neurobiological correlates to why women may be more vulnerable than men to conditions involving own body perception.
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- 2019
27. An Empirical Comparison of Meta- and Mega-Analysis With Data From the ENIGMA Obsessive-Compulsive Disorder Working Group
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Boedhoe, Premika SW, Heymans, Martijn W, Schmaal, Lianne, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie H, Anticevic, Alan, Arnold, Paul D, Batistuzzo, Marcelo C, Benedetti, Francesco, Beucke, Jan C, Bollettini, Irene, Bose, Anushree, Brem, Silvia, Calvo, Anna, Calvo, Rosa, Cheng, Yuqi, Cho, Kang Ik K, Ciullo, Valentina, Dallaspezia, Sara, Denys, Damiaan, Feusner, Jamie D, Fitzgerald, Kate D, Fouche, Jean-Paul, Fridgeirsson, Egill A, Gruner, Patricia, Hanna, Gregory L, Hibar, Derrek P, Hoexter, Marcelo Q, Hu, Hao, Huyser, Chaim, Jahanshad, Neda, James, Anthony, Kathmann, Norbert, Kaufmann, Christian, Koch, Kathrin, Kwon, Jun Soo, Lazaro, Luisa, Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Menchón, José M, Minuzzi, Luciano, Morer, Astrid, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswamy, Janardhanan C, Nishida, Seiji, Nurmi, Erika L, O'Neill, Joseph, Piacentini, John, Piras, Fabrizio, Piras, Federica, Reddy, YC Janardhan, Reess, Tim J, Sakai, Yuki, Sato, Joao R, Simpson, H Blair, Soreni, Noam, Soriano-Mas, Carles, Spalletta, Gianfranco, Stevens, Michael C, Szeszko, Philip R, Tolin, David F, van Wingen, Guido A, Venkatasubramanian, Ganesan, Walitza, Susanne, Wang, Zhen, Yun, Je-Yeon, Working-Group, ENIGMA-OCD, Thompson, Paul M, Stein, Dan J, van den Heuvel, Odile A, and Twisk, Jos WR
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Biomedical and Clinical Sciences ,Information and Computing Sciences ,Neurosciences ,Applied Computing ,Machine Learning ,neuroimaging ,MRI ,IPD meta-analysis ,mega-analysis ,linear mixed-effect models ,ENIGMA-OCD Working-Group ,Cognitive Sciences ,Applied computing ,Machine learning - Abstract
Objective: Brain imaging communities focusing on different diseases have increasingly started to collaborate and to pool data to perform well-powered meta- and mega-analyses. Some methodologists claim that a one-stage individual-participant data (IPD) mega-analysis can be superior to a two-stage aggregated data meta-analysis, since more detailed computations can be performed in a mega-analysis. Before definitive conclusions regarding the performance of either method can be drawn, it is necessary to critically evaluate the methodology of, and results obtained by, meta- and mega-analyses. Methods: Here, we compare the inverse variance weighted random-effect meta-analysis model with a multiple linear regression mega-analysis model, as well as with a linear mixed-effects random-intercept mega-analysis model, using data from 38 cohorts including 3,665 participants of the ENIGMA-OCD consortium. We assessed the effect sizes and standard errors, and the fit of the models, to evaluate the performance of the different methods. Results: The mega-analytical models showed lower standard errors and narrower confidence intervals than the meta-analysis. Similar standard errors and confidence intervals were found for the linear regression and linear mixed-effects random-intercept models. Moreover, the linear mixed-effects random-intercept models showed better fit indices compared to linear regression mega-analytical models. Conclusions: Our findings indicate that results obtained by meta- and mega-analysis differ, in favor of the latter. In multi-center studies with a moderate amount of variation between cohorts, a linear mixed-effects random-intercept mega-analytical framework appears to be the better approach to investigate structural neuroimaging data.
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- 2019
28. Differentiating weight-restored anorexia nervosa and body dysmorphic disorder using neuroimaging and psychometric markers.
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Vaughn, Don A, Kerr, Wesley T, Moody, Teena D, Cheng, Gigi K, Morfini, Francesca, Zhang, Aifeng, Leow, Alex D, Strober, Michael A, Cohen, Mark S, and Feusner, Jamie D
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Humans ,Diagnosis ,Differential ,Magnetic Resonance Imaging ,ROC Curve ,Anorexia Nervosa ,Psychometrics ,Image Processing ,Computer-Assisted ,Adolescent ,Adult ,Female ,Male ,Young Adult ,Body Dysmorphic Disorders ,Neuroimaging ,Biomarkers ,Data Analysis ,Diagnosis ,Differential ,Image Processing ,Computer-Assisted ,General Science & Technology - Abstract
Anorexia nervosa (AN) and body dysmorphic disorder (BDD) are potentially life-threatening conditions whose partially overlapping phenomenology-distorted perception of appearance, obsessions/compulsions, and limited insight-can make diagnostic distinction difficult in some cases. Accurate diagnosis is crucial, as the effective treatments for AN and BDD differ. To improve diagnostic accuracy and clarify the contributions of each of the multiple underlying factors, we developed a two-stage machine learning model that uses multimodal, neurobiology-based, and symptom-based quantitative data as features: task-based functional magnetic resonance imaging data using body visual stimuli, graph theory metrics of white matter connectivity from diffusor tensor imaging, and anxiety, depression, and insight psychometric scores. In a sample of unmedicated adults with BDD (n = 29), unmedicated adults with weight-restored AN (n = 24), and healthy controls (n = 31), the resulting model labeled individuals with an accuracy of 76%, significantly better than the chance accuracy of 35% ([Formula: see text]). In the multivariate model, reduced white matter global efficiency and better insight were associated more with AN than with BDD. These results improve our understanding of the relative contributions of the neurobiological characteristics and symptoms of these disorders. Moreover, this approach has the potential to aid clinicians in diagnosis, thereby leading to more tailored therapy.
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- 2019
29. Clinical MRI morphological analysis of functional seizures compared to seizure-naïve and psychiatric controls
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Kerr, Wesley T., Tatekawa, Hiroyuki, Lee, John K., Karimi, Amir H., Sreenivasan, Siddhika S., O'Neill, Joseph, Smith, Jena M., Hickman, L. Brian, Savic, Ivanka, Nasrullah, Nilab, Espinoza, Randall, Narr, Katherine, Salamon, Noriko, Beimer, Nicholas J., Hadjiiski, Lubomir M., Eliashiv, Dawn S., Stacey, William C., Engel, Jerome, Jr., Feusner, Jamie D., and Stern, John M.
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- 2022
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30. Neural and behavioral effects of modification of visual attention in body dysmorphic disorder
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Wong, Wan-Wa, Rangaprakash, D., Diaz-Fong, Joel P., Rotstein, Natalie M., Hellemann, Gerhard S., and Feusner, Jamie D.
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- 2022
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31. The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder
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Weeland, Cees J., Kasprzak, Selina, de Joode, Niels T., Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie H., Anticevic, Alan, Arnold, Paul D., Balachander, Srinivas, Banaj, Nerisa, Bargallo, Nuria, Batistuzzo, Marcelo C., Benedetti, Francesco, Beucke, Jan C., Bollettini, Irene, Brecke, Vilde, Brem, Silvia, Cappi, Carolina, Cheng, Yuqi, Cho, Kang Ik K., Costa, Daniel L. C., Dallaspezia, Sara, Denys, Damiaan, Eng, Goi Khia, Ferreira, Sónia, Feusner, Jamie D., Fontaine, Martine, Fouche, Jean-Paul, Grazioplene, Rachael G., Gruner, Patricia, He, Mengxin, Hirano, Yoshiyuki, Hoexter, Marcelo Q., Huyser, Chaim, Hu, Hao, Jaspers-Fayer, Fern, Kathmann, Norbert, Kaufmann, Christian, Kim, Minah, Koch, Kathrin, Bin Kwak, Yoo, Kwon, Jun Soo, Lazaro, Luisa, Li, Chiang-shan R., Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Menchón, Jose M., Minnuzi, Luciano, Moreira, Pedro Silva, Morgado, Pedro, Nakagawa, Akiko, Nakamae, Takashi, Narayanaswamy, Janardhanan C., Nurmi, Erika L., Ortiz, Ana E., Pariente, Jose C., Piacentini, John, Picó-Pérez, Maria, Piras, Fabrizio, Piras, Federica, Pittenger, Christopher, Reddy, Y. C. Janardhan, Rodriguez-Manrique, Daniela, Sakai, Yuki, Shimizu, Eiji, Shivakumar, Venkataram, Simpson, Helen Blair, Soreni, Noam, Soriano-Mas, Carles, Sousa, Nuno, Spalletta, Gianfranco, Stern, Emily R., Stevens, Michael C., Stewart, S. Evelyn, Szeszko, Philip R., Takahashi, Jumpei, Tanamatis, Tais, Tang, Jinsong, Thorsen, Anders Lillevik, Tolin, David, van der Werf, Ysbrand D., van Marle, Hein, van Wingen, Guido A., Vecchio, Daniela, Venkatasubramanian, G., Walitza, Susanne, Wang, Jicai, Wang, Zhen, Watanabe, Anri, Wolters, Lidewij H., Xu, Xiufeng, Yun, Je-Yeon, Zhao, Qing, White, Tonya, Thompson, Paul M., Stein, Dan J., van den Heuvel, Odile A., and Vriend, Chris
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- 2022
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32. Interoception and Mental Health: A Roadmap
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Khalsa, Sahib S, Adolphs, Ralph, Cameron, Oliver G, Critchley, Hugo D, Davenport, Paul W, Feinstein, Justin S, Feusner, Jamie D, Garfinkel, Sarah N, Lane, Richard D, Mehling, Wolf E, Meuret, Alicia E, Nemeroff, Charles B, Oppenheimer, Stephen, Petzschner, Frederike H, Pollatos, Olga, Rhudy, Jamie L, Schramm, Lawrence P, Simmons, W Kyle, Stein, Murray B, Stephan, Klaas E, Van den Bergh, Omer, Van Diest, Ilse, von Leupoldt, Andreas, Paulus, Martin P, participants, Interoception Summit 2016, Ainley, Vivien, Al Zoubi, Obada, Aupperle, Robin, Avery, Jason, Baxter, Leslie, Benke, Christoph, Berner, Laura, Bodurka, Jerzy, Breese, Eric, Brown, Tiffany, Burrows, Kaiping, Cha, Yoon-Hee, Clausen, Ashley, Cosgrove, Kelly, Deville, Danielle, Duncan, Laramie, Duquette, Patrice, Ekhtiari, Hamed, Fine, Thomas, Ford, Bart, Cordero, Indira Garcia, Gleghorn, Diamond, Guereca, Yvette, Harrison, Neil A, Hassanpour, Mahlega, Hechler, Tanja, Heller, Aaron, Hellman, Natalie, Herbert, Beate, Jarrahi, Behnaz, Kerr, Kara, Kirlic, Namik, Klabunde, Megan, Kraynak, Thomas, Kriegsman, Michael, Kroll, Juliet, Kuplicki, Rayus, Lapidus, Rachel, Le, Trang, Hagen, Kyle Logie, Mayeli, Ahmad, Morris, Amanda, Naqvi, Nasir, Oldroyd, Kristina, Pané-Farré, Christiane, Phillips, Raquel, Poppa, Tasha, Potter, Willliam, Puhl, Maria, Safron, Adam, Sala, Margaret, Savitz, Jonathan, Saxon, Heather, Schoenhals, Will, Stanwell-Smith, Colin, Teed, Adam, Terasawa, Yuri, Thompson, Katie, Toups, Marisa, Umeda, Satoshi, Upshaw, Valerie, Victor, Teresa, Wierenga, Christina, Wohlrab, Colleen, Yeh, Hung-wen, Yoris, Adrian, Zeidan, Fadel, Zotev, Vadim, and Zucker, Nancy
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Clinical and Health Psychology ,Psychology ,Behavioral and Social Science ,Brain Disorders ,Mental Health ,Mental health ,Good Health and Well Being ,Awareness ,Brain ,Cognition ,Emotions ,Humans ,Interoception ,Biomarker ,Computational psychiatry ,Research Domain Criteria ,Treatment ,Interoception Summit 2016 participants ,Neurosciences ,Biological psychology ,Clinical and health psychology - Abstract
Interoception refers to the process by which the nervous system senses, interprets, and integrates signals originating from within the body, providing a moment-by-moment mapping of the body's internal landscape across conscious and unconscious levels. Interoceptive signaling has been considered a component process of reflexes, urges, feelings, drives, adaptive responses, and cognitive and emotional experiences, highlighting its contributions to the maintenance of homeostatic functioning, body regulation, and survival. Dysfunction of interoception is increasingly recognized as an important component of different mental health conditions, including anxiety disorders, mood disorders, eating disorders, addictive disorders, and somatic symptom disorders. However, a number of conceptual and methodological challenges have made it difficult for interoceptive constructs to be broadly applied in mental health research and treatment settings. In November 2016, the Laureate Institute for Brain Research organized the first Interoception Summit, a gathering of interoception experts from around the world, with the goal of accelerating progress in understanding the role of interoception in mental health. The discussions at the meeting were organized around four themes: interoceptive assessment, interoceptive integration, interoceptive psychopathology, and the generation of a roadmap that could serve as a guide for future endeavors. This review article presents an overview of the emerging consensus generated by the meeting.
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- 2018
33. Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group
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Boedhoe, Premika SW, Schmaal, Lianne, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie H, Anticevic, Alan, Arnold, Paul D, Batistuzzo, Marcelo C, Benedetti, Francesco, Beucke, Jan C, Bollettini, Irene, Bose, Anushree, Brem, Silvia, Calvo, Anna, Calvo, Rosa, Cheng, Yuqi, Cho, Kang Ik K, Ciullo, Valentina, Dallaspezia, Sara, Denys, Damiaan, Feusner, Jamie D, Fitzgerald, Kate D, Fouche, Jean-Paul, Fridgeirsson, Egill A, Gruner, Patricia, Hanna, Gregory L, Hibar, Derrek P, Hoexter, Marcelo Q, Hu, Hao, Huyser, Chaim, Jahanshad, Neda, James, Anthony, Kathmann, Norbert, Kaufmann, Christian, Koch, Kathrin, Kwon, Jun Soo, Lazaro, Luisa, Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Menchón, José M, Minuzzi, Luciano, Morer, Astrid, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswamy, Janardhanan C, Nishida, Seiji, Nurmi, Erika, O’Neill, Joseph, Piacentini, John, Piras, Fabrizio, Piras, Federica, Reddy, YC Janardhan, Reess, Tim J, Sakai, Yuki, Sato, Joao R, Simpson, H Blair, Soreni, Noam, Soriano-Mas, Carles, Spalletta, Gianfranco, Stevens, Michael C, Szeszko, Philip R, Tolin, David F, van Wingen, Guido A, Venkatasubramanian, Ganesan, Walitza, Susanne, Wang, Zhen, Yun, Je-Yeon, Thompson, Paul M, Stein, Dan J, van den Heuvel, Odile A, Bargalló, Nuria, Brandeis, Daniel, Buimer, Elizabeth, Busatto, Geraldo F, de Vries, Froukje E, de Wit, Stella J, Drechsler, Renate, and Falini, Andrea
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Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Pediatric ,Neurosciences ,Mental Health ,Serious Mental Illness ,Brain Disorders ,Neurological ,Mental health ,Adolescent ,Adult ,Age of Onset ,Cerebral Cortex ,Child ,Frontal Lobe ,Humans ,Magnetic Resonance Imaging ,Obsessive-Compulsive Disorder ,Parietal Lobe ,Reference Values ,Temporal Lobe ,Young Adult ,ENIGMA-OCD Working Group ,ENIGMA OCD Working Group ,Cortical Thickness ,FreeSurfer ,MRI ,Surface Area ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Clinical sciences ,Clinical and health psychology - Abstract
ObjectiveBrain imaging studies of structural abnormalities in OCD have yielded inconsistent results, partly because of limited statistical power, clinical heterogeneity, and methodological differences. The authors conducted meta- and mega-analyses comprising the largest study of cortical morphometry in OCD ever undertaken.MethodT1-weighted MRI scans of 1,905 OCD patients and 1,760 healthy controls from 27 sites worldwide were processed locally using FreeSurfer to assess cortical thickness and surface area. Effect sizes for differences between patients and controls, and associations with clinical characteristics, were calculated using linear regression models controlling for age, sex, site, and intracranial volume.ResultsIn adult OCD patients versus controls, we found a significantly lower surface area for the transverse temporal cortex and a thinner inferior parietal cortex. Medicated adult OCD patients also showed thinner cortices throughout the brain. In pediatric OCD patients compared with controls, we found significantly thinner inferior and superior parietal cortices, but none of the regions analyzed showed significant differences in surface area. However, medicated pediatric OCD patients had lower surface area in frontal regions. Cohen's d effect sizes varied from -0.10 to -0.33.ConclusionsThe parietal cortex was consistently implicated in both adults and children with OCD. More widespread cortical thickness abnormalities were found in medicated adult OCD patients, and more pronounced surface area deficits (mainly in frontal regions) were found in medicated pediatric OCD patients. These cortical measures represent distinct morphological features and may be differentially affected during different stages of development and illness, and possibly moderated by disease profile and medication.
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- 2018
34. Testosterone Effects on the Brain in Transgender Men
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Burke, Sarah M, Manzouri, Amir H, Dhejne, Cecilia, Bergström, Karin, Arver, Stefan, Feusner, Jamie D, and Savic-Berglund, Ivanka
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Neurosciences ,Sexual and Gender Minorities (SGM/LGBT*) ,Underpinning research ,1.1 Normal biological development and functioning ,Adolescent ,Adult ,Androgens ,Brain ,Case-Control Studies ,Cross-Sectional Studies ,Diffusion Tensor Imaging ,Female ,Humans ,Image Processing ,Computer-Assisted ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Nerve Net ,Neural Pathways ,Oxygen ,Self Concept ,Testosterone ,Transgender Persons ,Young Adult ,cortical thickness ,diffusion tensor imaging ,functional connectivity ,testosterone ,transgender ,Psychology ,Cognitive Sciences ,Experimental Psychology - Abstract
Transgender individuals experience incongruence between their gender identity and birth-assigned sex. The resulting gender dysphoria (GD), which some gender-incongruent individuals experience, is theorized to be a consequence of atypical cerebral sexual differentiation, but support for this assertion is inconsistent. We recently found that GD is associated with disconnected networks involved in self-referential thinking and own body perception. Here, we investigate how these networks in trans men (assigned female at birth with male gender identity) are affected by testosterone. In 22 trans men, we obtained T1-weighted, diffusion-weighted, and resting-state functional magnetic resonance imaging scans before and after testosterone treatment, measuring cortical thickness (Cth), subcortical volumes, fractional anisotropy (FA), and functional connectivity. Nineteen cisgender controls (male and female) were also scanned twice. The medial prefrontal cortex (mPFC) was thicker in trans men than controls pretreatment, and remained unchanged posttreatment. Testosterone treatment resulted in increased Cth in the insular cortex, changes in cortico-cortical thickness covariation between mPFC and occipital cortex, increased FA in the fronto-occipital tract connecting these regions, and increased functional connectivity between mPFC and temporo-parietal junction, compared with controls. Concluding, in trans men testosterone treatment resulted in functional and structural changes in self-referential and own body perception areas.
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- 2018
35. Pregenual Anterior Cingulate Dysfunction Associated with Depression in OCD: An Integrated Multimodal fMRI/1H MRS Study
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Tadayonnejad, Reza, Deshpande, Rangaprakash, Ajilore, Olusola, Moody, Teena, Morfini, Francesca, Ly, Ronald, O'Neill, Joseph, and Feusner, Jamie D
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Biological Psychology ,Biomedical and Clinical Sciences ,Clinical Sciences ,Psychology ,Neurosciences ,Mental Health ,Depression ,Brain Disorders ,Anxiety Disorders ,Serious Mental Illness ,Clinical Research ,Aetiology ,2.1 Biological and endogenous factors ,Mental health ,Adult ,Case-Control Studies ,Female ,Functional Neuroimaging ,Glutamic Acid ,Gyrus Cinguli ,Humans ,Magnetic Resonance Imaging ,Male ,Neural Pathways ,Obsessive-Compulsive Disorder ,Proton Magnetic Resonance Spectroscopy ,Young Adult ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Biological psychology - Abstract
Depression is a commonly occurring symptom in obsessive-compulsive disorder (OCD), and is associated with worse functional impairment, poorer quality of life, and poorer treatment response. Understanding the underlying neurochemical and connectivity-based brain mechanisms of this important symptom domain in OCD is necessary for development of novel, more globally effective treatments. To investigate biopsychological mechanisms of comorbid depression in OCD, we examined effective connectivity and neurochemical signatures in the pregenual anterior cingulate cortex (pACC), a structure known to be involved in both OCD and depression. Resting-state functional magnetic resonance imaging (fMRI) and 1H magnetic resonance spectroscopy (MRS) data were obtained from participants with OCD (n=49) and healthy individuals of equivalent age and sex (n=25). Granger causality-based effective (directed) connectivity was used to define causal networks involving the right and left pACC. The interplay between fMRI connectivity, 1H MRS and clinical data was explored by applying moderation and mediation analyses. We found that the causal influence of the right dorsal anterior midcingulate cortex (daMCC) on the right pACC was significantly lower in the OCD group and showed significant correlation with depressive symptom severity in the OCD group. Lower and moderate levels of glutamate (Glu) in the right pACC significantly moderated the interaction between right daMCC-pACC connectivity and depression severity. Our results suggest a biochemical-connectivity-psychological model of pACC dysfunction contributing to depression in OCD, particularly involving intracingulate connectivity and glutamate levels in the pACC. These findings have implications for potential molecular and network targets for treatment of this multi-faceted psychiatric condition.
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- 2018
36. Multivariate resting-state functional connectivity predicts response to cognitive behavioral therapy in obsessive-compulsive disorder.
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Reggente, Nicco, Moody, Teena D, Morfini, Francesca, Sheen, Courtney, Rissman, Jesse, O'Neill, Joseph, and Feusner, Jamie D
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Neural Pathways ,Humans ,Magnetic Resonance Imaging ,Treatment Outcome ,Brain Mapping ,Multivariate Analysis ,Pattern Recognition ,Physiological ,Obsessive-Compulsive Disorder ,Adolescent ,Adult ,Middle Aged ,Female ,Male ,Young Adult ,Cognitive Behavioral Therapy ,CBT ,OCD ,functional connectivity ,machine learning ,resting state ,Pattern Recognition ,Physiological ,Behavioral and Social Science ,Serious Mental Illness ,Clinical Research ,Mental Health ,Anxiety Disorders ,Brain Disorders ,Mind and Body ,4.1 Discovery and preclinical testing of markers and technologies ,Cognitive Therapy ,MD Multidisciplinary - Abstract
Cognitive behavioral therapy (CBT) is an effective treatment for many with obsessive-compulsive disorder (OCD). However, response varies considerably among individuals. Attaining a means to predict an individual's potential response would permit clinicians to more prudently allocate resources for this often stressful and time-consuming treatment. We collected resting-state functional magnetic resonance imaging from adults with OCD before and after 4 weeks of intensive daily CBT. We leveraged machine learning with cross-validation to assess the power of functional connectivity (FC) patterns to predict individual posttreatment OCD symptom severity. Pretreatment FC patterns within the default mode network and visual network significantly predicted posttreatment OCD severity, explaining up to 67% of the variance. These networks were stronger predictors than pretreatment clinical scores. Results have clinical implications for developing personalized medicine approaches to identifying individual OCD patients who will maximally benefit from intensive CBT.
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- 2018
37. Relationships between obsessive-compulsive disorder, depression and functioning before and after exposure and response prevention therapy
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Motivala, Sarosh J, Arellano, Maria, Greco, Rebecca L, Aitken, David, Hutcheson, Nathan, Tadayonnejad, Reza, O’Neill, Joseph, and Feusner, Jamie D
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Clinical and Health Psychology ,Psychology ,Mental Health ,Prevention ,Brain Disorders ,Mind and Body ,Anxiety Disorders ,Serious Mental Illness ,Clinical Research ,Depression ,Behavioral and Social Science ,Evaluation of treatments and therapeutic interventions ,6.6 Psychological and behavioural ,Mental health ,Adult ,Cognitive Behavioral Therapy ,Female ,Humans ,Implosive Therapy ,Male ,Middle Aged ,Obsessive-Compulsive Disorder ,Outcome Assessment ,Health Care ,Rumination ,Cognitive ,Cogntive-behavioural therapy ,obsessive-compulsive disorder ,mediation ,global functioning ,depression ,Clinical Sciences ,Psychiatry ,Clinical sciences ,Clinical and health psychology - Abstract
ObjectiveObsessive-compulsive disorder (OCD) is associated with impaired functioning and depression. Our aim was to examine relationships between OCD symptoms, depression and functioning before and after exposure and response prevention (ERP), a type of cognitive-behavioural therapy for OCD, specifically examining whether functioning, depression and other cognitive factors like rumination and worry acted as mediators.MethodsForty-four individuals with OCD were randomised to 4 weeks of intensive ERP treatment first (n = 23) or waitlist then treatment (n = 21). We used a bootstrapping method to examine mediation models.ResultsOCD symptoms, depression and functioning significantly improved from pre- to post-intervention. Functioning mediated the relationship between OCD symptoms and depression and the relationship between functioning and depression was stronger at post-treatment. Depression mediated the relationship between OCD symptoms and functioning, but only at post-intervention. Similarly, rumination mediated the relationship between OCD symptoms and depression at post-intervention.ConclusionsOur findings suggest that after ERP, relationships between depression and functioning become stronger. Following ERP, treatment that focuses on depression and functioning, including medication management for depression, cognitive approaches targeting rumination, and behavioural activation to boost functionality may be important clinical interventions for OCD patients.
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- 2018
38. Aberrant Dynamic Connectivity for Fear Processing in Anorexia Nervosa and Body Dysmorphic Disorder
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Rangaprakash, D, Bohon, Cara, Lawrence, Katherine E, Moody, Teena, Morfini, Francesca, Khalsa, Sahib S, Strober, Michael, and Feusner, Jamie D
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Biomedical and Clinical Sciences ,Clinical Sciences ,Brain Disorders ,Mental Health ,Basic Behavioral and Social Science ,Nutrition ,Mind and Body ,Eating Disorders ,Neurosciences ,Anorexia ,Clinical Research ,Behavioral and Social Science ,Serious Mental Illness ,Aetiology ,2.1 Biological and endogenous factors ,Underpinning research ,1.1 Normal biological development and functioning ,Mental health ,fearful face processing ,dynamic effective connectivity ,fronto-limbic modulation ,anorexia nervosa ,body dysmorphic disorder ,Public Health and Health Services ,Psychology ,Clinical sciences - Abstract
Anorexia nervosa (AN) and body dysmorphic disorder (BDD) share distorted perceptions of appearance with extreme negative emotion, yet the neural phenotypes of emotion processing remain underexplored in them, and they have never been directly compared. We sought to determine if shared and disorder-specific fronto-limbic connectivity patterns characterize these disorders. FMRI data was obtained from three unmedicated groups: BDD (n = 32), weight-restored AN (n = 25), and healthy controls (HC; n = 37), while they viewed fearful faces and rated their own degree of fearfulness in response. We performed dynamic effective connectivity modeling with medial prefrontal cortex (mPFC), rostral anterior cingulate cortex (rACC), and amygdala as regions-of-interest (ROI), and assessed associations between connectivity and clinical variables. HCs exhibited significant within-group bidirectional mPFC-amygdala connectivity, which increased across the blocks, whereas BDD participants exhibited only significant mPFC-to-amygdala connectivity (P < 0.05, family-wise error corrected). In contrast, participants with AN lacked significant prefrontal-amygdala connectivity in either direction. AN showed significantly weaker mPFC-to-amygdala connectivity compared to HCs (P = 0.0015) and BDD (P = 0.0050). The mPFC-to-amygdala connectivity was associated with greater subjective fear ratings (R2 = 0.11, P = 0.0016), eating disorder symptoms (R2 = 0.33, P = 0.0029), and anxiety (R2 = 0.29, P = 0.0055) intensity scores. Our findings, which suggest a complex nosological relationship, have implications for understanding emotion regulation circuitry in these related psychiatric disorders, and may have relevance for current and novel therapeutic approaches.
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- 2018
39. Interoceptive Anxiety and Body Representation in Anorexia Nervosa.
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Khalsa, Sahib S, Hassanpour, Mahlega S, Strober, Michael, Craske, Michelle G, Arevian, Armen C, and Feusner, Jamie D
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anxiety ,arousal ,dyspnea ,eating disorder ,fear ,interoception ,palpitation ,panic ,Serious Mental Illness ,Behavioral and Social Science ,Clinical Research ,Mental Health ,Anxiety Disorders ,Nutrition ,Eating Disorders ,Anorexia ,Aetiology ,2.3 Psychological ,social and economic factors ,Mental health ,Clinical Sciences ,Public Health and Health Services ,Psychology - Abstract
Individuals with anorexia nervosa (AN) typically display anxious traits prior to the onset of food avoidance and weight loss that characterize the disorder. Meal associated anxiety is an especially common clinical feature in these patients, and heightened sensitivity to sympathetically mediated interoceptive sensations has also been observed. However, it remains unclear how heightened interoceptive sensitivity relates to experiences of anxiety before and after meals. To investigate this relationship, we experimentally induced anxiety and panic symptoms with isoproterenol, a peripheral sympathetic agonist similar to adrenaline, across several different conditions: during panic provocation, during anticipation of a 1,000 Calorie meal, and after meal consumption. Fifteen AN and 15 age- and sex-matched healthy comparisons received bolus infusions of isoproterenol and saline in a double-blinded, randomized design. Participants rated anxiety symptoms after each infusion, completed panic rating scales, and traced the location of perceived palpitations on a manikin to index interoceptive "body map" representation. The AN group reported significantly elevated anxiety relative to healthy comparisons during infusions before and after the meal, but surprisingly, not during panic provocation. These symptoms were accompanied by geographical differences in patterns of perceived heartbeat sensations across each condition. In particular, the AN group localized heartbeat sensations disproportionately to the chest during meal related saline infusions, when no cardiorespiratory modulation actually occurred. The AN group also showed a trend toward higher panic attack rates during the meal anticipation period. Correcting for anxiety levels reported during saline infusions abolished group differences in anxiety change across all conditions, suggesting a significant contribution of anxious traits in AN. The observation of meal related "visceral illusions" provides further evidence that AN is associated with abnormal interoceptive representation of the heartbeat and suggests that meal consumption, particularly when anticipated, preferentially alters the processing of interoception related signals in AN.
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- 2018
40. What happens after treatment? A systematic review of relapse, remission, and recovery in anorexia nervosa
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Khalsa, Sahib S, Portnoff, Larissa C, McCurdy-McKinnon, Danyale, and Feusner, Jamie D
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Health Sciences ,Psychology ,Eating Disorders ,Anorexia ,Clinical Research ,Mental Health ,Nutrition ,Good Health and Well Being ,Anorexia nervosa ,Treatment ,Outcome ,Relapse ,Remission ,Recovery ,Prevention ,Eating disorder ,Bulimia nervosa ,Nutrition and Dietetics ,Health sciences - Abstract
BackgroundRelapse after treatment for anorexia nervosa (AN) is a significant clinical problem. Given the level of chronicity, morbidity, and mortality experienced by this population, it is imperative to understand the driving forces behind apparently high relapse rates. However, there is a lack of consensus in the field on an operational definition of relapse, which hinders precise and reliable estimates of the severity of this issue. The primary goal of this paper was to review prior studies of AN addressing definitions of relapse, as well as relapse rates.MethodsData sources included PubMed and PsychINFO through March 19th, 2016. A systematic review was performed following the PRISMA guidelines. A total of (N = 27) peer-reviewed English language studies addressing relapse, remission, and recovery in AN were included.ResultsDefinitions of relapse in AN as well as definitions of remission or recovery, on which relapse is predicated, varied substantially in the literature. Reported relapse rates ranged between 9 and 52%, and tended to increase with increasing duration of follow-up. There was consensus that risk for relapse in persons with AN is especially high within the first year following treatment.DiscussionStandardized definitions of relapse, as well as remission and recovery, are needed in AN to accelerate clinical and research progress. This should improve the ability of future longitudinal studies to identify clinical, demographic, and biological characteristics in AN that predict relapse versus resilience, and to comparatively evaluate relapse prevention strategies. We propose standardized criteria for relapse, remission, and recovery, for further consideration.
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- 2017
41. Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease.
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Harrison, Theresa M, McLaren, Donald G, Moody, Teena D, Feusner, Jamie D, and Bookheimer, Susan Y
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Brain ,Humans ,Alzheimer Disease ,Magnetic Resonance Imaging ,Risk Factors ,Memory ,Adult ,Aged ,Middle Aged ,Female ,Male ,Mental Health ,Behavioral and Social Science ,Neurosciences ,Basic Behavioral and Social Science ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Neurodegenerative ,Dementia ,Brain Disorders ,Alzheimer's Disease ,Clinical Research ,Acquired Cognitive Impairment ,Aging ,Aetiology ,Underpinning research ,2.1 Biological and endogenous factors ,1.2 Psychological and socioeconomic processes ,Mental health ,Neurological ,Neurobiology ,Issue 129 ,Functional connectivity ,hippocampus ,functional magnetic resonance imaging ,fMRI preprocessing ,fMRI statistical analysis ,MRI ,genetic risk ,APOE ,psychophysiological interaction ,generalized psychophysiological interaction ,Biochemistry and Cell Biology ,Psychology ,Cognitive Sciences - Abstract
In neuroimaging, functional magnetic resonance imaging (fMRI) measures the blood-oxygenation-level dependent (BOLD) signal in the brain. The degree of correlation of the BOLD signal in spatially independent regions of the brain defines the functional connectivity of those regions. During a cognitive fMRI task, a psychophysiological interaction (PPI) analysis can be used to examine changes in the functional connectivity during specific contexts defined by the cognitive task. An example of such a task is one that engages the memory system, asking participants to learn pairs of unrelated words (encoding) and recall the second word in a pair when presented with the first word (retrieval). In the present study, we used this type of associative memory task and a generalized PPI (gPPI) analysis to compare changes in hippocampal connectivity in older adults who are carriers of the Alzheimer's disease (AD) genetic risk factor apolipoprotein-E epsilon-4 (APOEε4). Specifically, we show that the functional connectivity of subregions of the hippocampus changes during encoding and retrieval, the two active phases of the associative memory task. Context-dependent changes in functional connectivity of the hippocampus were significantly different in carriers of APOEε4 compared to non-carriers. PPI analyses make it possible to examine changes in functional connectivity, distinct from univariate main effects, and to compare these changes across groups. Thus, a PPI analysis may reveal complex task effects in specific cohorts that traditional univariate methods do not capture. PPI analyses cannot, however, determine directionality or causality between functionally connected regions. Nevertheless, PPI analyses provide powerful means for generating specific hypotheses regarding functional relationships, which can be tested using causal models. As the brain is increasingly described in terms of connectivity and networks, PPI is an important method for analyzing fMRI task data that is in line with the current conception of the human brain.
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- 2017
42. Functional seizures across the adult lifespan: female sex, delay to diagnosis and disability
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Kerr, Wesley T., Sreenivasan, Siddhika S., Allas, Corinne H., Janio, Emily A., Karimi, Amir H., Dubey, Ishita, D'Ambrosio, Shannon R., Smith, Jena M., Engel, Jerome, Jr., Feusner, Jamie D., and Stern, John M.
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- 2021
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43. A minority of patients with functional seizures have abnormalities on neuroimaging
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Kerr, Wesley T., Lee, John K., Karimi, Amir H., Tatekawa, Hiroyuki, Hickman, L. Brian, Connerney, Michael, Sreenivasan, Siddhika S., Dubey, Ishita, Allas, Corinne H., Smith, Jena M., Savic, Ivanka, Silverman, Daniel H.S., Hadjiiski, Lubomir M., Beimer, Nicholas J., Stacey, William C., Cohen, Mark S., Engel, Jerome, Jr, Feusner, Jamie D., Salamon, Noriko, and Stern, John M.
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- 2021
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44. Factors associated with delay to video-EEG in dissociative seizures
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Kerr, Wesley T., Zhang, Xingruo, Hill, Chloe E., Janio, Emily A., Chau, Andrea M., Braesch, Chelsea T., Le, Justine M., Hori, Jessica M., Patel, Akash B., Allas, Corinne H., Karimi, Amir H., Dubey, Ishita, Sreenivasan, Siddhika S., Gallardo, Norma L., Bauirjan, Janar, Hwang, Eric S., Davis, Emily C., D'Ambrosio, Shannon R., Al Banna, Mona, Cho, Andrew Y., Dewar, Sandra R., Engel, Jerome, Jr., Feusner, Jamie D., and Stern, John M.
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- 2021
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45. Epilepsy, dissociative seizures, and mixed: Associations with time to video-EEG
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Kerr, Wesley T., Zhang, Xingruo, Hill, Chloe E., Janio, Emily A., Chau, Andrea M., Braesch, Chelsea T., Le, Justine M., Hori, Jessica M., Patel, Akash B., Allas, Corinne H., Karimi, Amir H., Dubey, Ishita, Sreenivasan, Siddhika S., Gallardo, Norma L., Bauirjan, Janar, Hwang, Eric S., Davis, Emily C., D’Ambrosio, Shannon R., Al Banna, Mona, Cho, Andrew Y., Dewar, Sandra R., Engel, Jerome, Jr., Feusner, Jamie D., and Stern, John M.
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- 2021
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46. Reliability of additional reported seizure manifestations to identify dissociative seizures
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Kerr, Wesley T., Zhang, Xingruo, Janio, Emily A., Karimi, Amir H., Allas, Corinne H., Dubey, Ishita, Sreenivasan, Siddhika S., Bauirjan, Janar, D'Ambrosio, Shannon R., Al Banna, Mona, Cho, Andrew Y., Engel Jr, Jerome, Cohen, Mark S., Feusner, Jamie D., and Stern, John M.
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- 2021
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47. Intrinsic network connectivity and own body perception in gender dysphoria.
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Feusner, Jamie D, Lidström, Andreas, Moody, Teena D, Dhejne, Cecilia, Bookheimer, Susan Y, and Savic, Ivanka
- Subjects
Brain ,Neural Pathways ,Humans ,Magnetic Resonance Imaging ,Brain Mapping ,Cross-Sectional Studies ,Gender Identity ,Body Image ,Transsexualism ,Rest ,Adolescent ,Adult ,Female ,Male ,Young Adult ,Transgender Persons ,Gender Dysphoria ,Body identification ,Body image ,Gender identity disorder ,Resting state fMRI ,Transgender ,Transsexual ,Basic Behavioral and Social Science ,Behavioral and Social Science ,Neurosciences ,Clinical Research ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Experimental Psychology - Abstract
Gender dysphoria (GD) is characterized by incongruence between one's identity and gender assigned at birth. The biological mechanisms of GD are unclear. We investigated brain network connectivity patterns involved in own body perception in the context of self in GD. Twenty-seven female-to-male (FtM) individuals with GD, 27 male controls, and 27 female controls underwent resting state fMRI. We compared functional connections within intrinsic connectivity networks involved in self-referential processes and own body perception -default mode network (DMN) and salience network - and visual networks, using independent components analyses. Behavioral correlates of network connectivity were also tested using self-perception ratings while viewing own body images morphed to their sex assigned at birth, and to the sex of their gender identity. FtM exhibited decreased connectivity of anterior and posterior cingulate and precuneus within the DMN compared with controls. In FtM, higher "self" ratings for bodies morphed towards the sex of their gender identity were associated with greater connectivity of the anterior cingulate within the DMN, during long viewing times. In controls, higher ratings for bodies morphed towards their gender assigned at birth were associated with right insula connectivity within the salience network, during short viewing times. Within visual networks FtM showed weaker connectivity in occipital and temporal regions. Results suggest disconnectivity within networks involved in own body perception in the context of self in GD. Moreover, perception of bodies in relation to self may be reflective rather than reflexive, as a function of mesial prefrontal processes. These may represent neurobiological correlates to the subjective disconnection between perception of body and self-identification.
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- 2017
48. Appearance evaluation of others' faces and bodies in anorexia nervosa and body dysmorphic disorder
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Moody, Teena D, Shen, Vivian W, Hutcheson, Nathan L, Henretty, Jennifer R, Sheen, Courtney L, Strober, Michael, and Feusner, Jamie D
- Subjects
Public Health ,Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Health Sciences ,Eating Disorders ,Anorexia ,Mental Health ,Nutrition ,Serious Mental Illness ,Clinical Research ,Adult ,Anorexia Nervosa ,Body Dysmorphic Disorders ,Body Image ,Face ,Female ,Humans ,Male ,Overweight ,Thinness ,Young Adult ,anorexia nervosa ,appearance evaluation ,body ,body dysmorphic disorder ,face ,overweight ,spatial frequency ,visual processing ,attractiveness ratings ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Clinical Psychology ,Nutrition and dietetics ,Public health - Abstract
ObjectiveIndividuals with anorexia nervosa (AN) and body dysmorphic disorder (BDD) exhibit distorted perception and negative evaluations of their own appearance; however, little is known about how they perceive others' appearance, and whether or not the conditions share perceptual distortions.MethodThirty participants with BDD, 22 with AN, now weight-restored, and 39 healthy comparison participants (HC) rated photographs of others' faces and bodies on attractiveness, how overweight or underweight they were, and how much photographs triggered thoughts of their own appearance. We compared responses among groups by stimulus type and by level-of-detail (spatial frequency).ResultsCompared to HCs, AN and BDD had lower attractiveness ratings for others' bodies and faces for high-detail and low-detail images, rated bodies as more overweight, and were more triggered to think of their own appearance for faces and bodies. In AN, symptom severity was associated with greater triggering of thoughts of own appearance and higher endorsement of overweight ratings for bodies. In BDD, symptom severity was associated with greater triggering of thoughts of own appearance for bodies and higher overweight ratings for low-detail images. BDD was more triggered to think of own facial appearance than AN.DiscussionAN and BDD show similar behavioral phenotypes of negative appearance evaluations for others' faces and bodies, and have thoughts of their own appearance triggered even for images outside of their primary appearance concerns, suggesting a more complex cross-disorder body-image phenotype than previously assumed. Future treatment strategies may benefit from addressing how these individuals evaluate others in addition to themselves. © 2016 Wiley Periodicals, Inc.(Int J Eat Disord 2017; 50:127-138).
- Published
- 2017
49. Brain activation and connectivity in anorexia nervosa and body dysmorphic disorder when viewing bodies: relationships to clinical symptoms and perception of appearance
- Author
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Moody, Teena D., Morfini, Francesca, Cheng, Gigi, Sheen, Courtney L., Kerr, Wesley T, Strober, Michael, and Feusner, Jamie D.
- Published
- 2021
- Full Text
- View/download PDF
50. How the heart speaks to the brain: neural activity during cardiorespiratory interoceptive stimulation
- Author
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Hassanpour, Mahlega S, Yan, Lirong, Wang, Danny JJ, Lapidus, Rachel C, Arevian, Armen C, Simmons, W Kyle, Feusner, Jamie D, and Khalsa, Sahib S
- Subjects
Clinical Research ,Neurosciences ,1.1 Normal biological development and functioning ,Underpinning research ,Neurological ,Good Health and Well Being ,Adrenergic beta-Agonists ,Adult ,Cerebral Cortex ,Female ,Heart Rate ,Humans ,Interoception ,Isoproterenol ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Oxygen ,Respiratory Rate ,Young Adult ,interoception ,cardiac ,respiration ,insula ,pharmacological functional magnetic resonance imaging ,emotion ,Biological Sciences ,Medical and Health Sciences ,Evolutionary Biology - Abstract
Prominent theories emphasize key roles for the insular cortex in the central representation of interoceptive sensations, but how this brain region responds dynamically to changes in interoceptive state remains incompletely understood. Here, we systematically modulated cardiorespiratory sensations in humans using bolus infusions of isoproterenol, a rapidly acting peripheral beta-adrenergic agonist similar to adrenaline. To identify central neural processes underlying these parametrically modulated interoceptive states, we used pharmacological functional magnetic resonance imaging (phMRI) to simultaneously measure blood-oxygenation-level dependent (BOLD) and arterial spin labelling (ASL) signals in healthy participants. Isoproterenol infusions induced dose-dependent increases in heart rate and cardiorespiratory interoception, with all participants endorsing increased sensations at the highest dose. These reports were accompanied by increased BOLD and ASL activation of the right insular cortex at the highest dose. Different responses across insula subregions were also observed. During anticipation, insula activation increased in more anterior regions. During stimulation, activation increased in the mid-dorsal and posterior insula on the right, but decreased in the same regions on the left. This study demonstrates the feasibility of phMRI for assessing brain activation during adrenergic interoceptive stimulation, and provides further evidence supporting a dynamic role for the insula in representing changes in cardiorespiratory states.This article is part of the themed issue 'Interoception beyond homeostasis: affect, cognition and mental health'.
- Published
- 2016
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