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147 results on '"Feuser, Paulo Emilio"'

2. Preparation and characterization of full-spectrum cannabis extract loaded poly(thioether-ester) nanoparticles: In vitro evaluation of their antitumoral efficacy

Author

Freire, Nathália Freitas, Feuser, Paulo Emílio, Ambel, Elena Maria Tovar, Cordani, Marco, Pieri, Ellen De, Machado-de-Ávila, Ricardo Andrez, Zielinski, Acácio A.F., Sayer, Claudia, de Araújo, Pedro Henrique Hermes, Díez, Guillermo Velasco, Albuquerque, Elaine Cabral, and Fialho, Rosana Lopes Lima

Published
2023
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10. Co-encapsulation of sodium diethyldithiocarbamate (DETC) and zinc phthalocyanine (ZnPc) in liposomes promotes increases phototoxic activity against (MDA-MB 231) human breast cancer cells

Author

Feuser, Paulo Emilio, Cordeiro, Arthur Poester, de Bem Silveira, Gustavo, Borges Corrêa, Maria Eduarda Anastácio, Lock Silveira, Paulo Cesar, Sayer, Claudia, de Araújo, Pedro Henrique Hermes, Machado-de-Ávila, Ricardo Andrez, and Dal Bó, Alexandre Gonçalves

Published
2021
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11. Green synthesis of gold nanoparticles in an animal model of chronic wound induced with Resiquimod.

Author

Mendes, Carolini, Zaccaron, Rubya Pereira, Casagrande, Laura de Roch, Venturini, Ligia Milanez, da Costa, Camila, Lima, Igor Ramos, Wermuth, Tiago Bender, Arcaro, Sabrina, Feuser, Paulo Emilio, and Lock Silveira, Paulo Cesar

Subjects
CHRONIC wounds & injuries, GOLD nanoparticles, TISSUES, LABORATORY rats, OXIDATIVE stress
Abstract

Cost-effective strategies for the treatment of chronic wounds must be developed. The green synthesis of gold nanoparticles (GNPs) it is possible to guarantee a lower toxicity in biological tissues and greater safety of applicability, in addition to adding the effects of nanoparticles (NPs) to those of extracts. The objective of this study was to evaluate the effects of treatment with biosynthesized GNPs in a chronic wound model. Wistar rats were distributed into 7 groups: Acute Wound (AW); Chronic wound (CW); CW + GNPs-Açaí; CW + GNPs-DB; CW + AV-GNPs; CW + SafGel®; CW + 660 nm laser. The chronic injury model was induced with topically applied Resiquimod for 6 days. Treatments were then initated on the fourteenth day after the last application of Resiquimod and carried out daily for ten days. The proposed therapies with GNPs were able to significantly reduce the inflammatory score and increase the rate of wound contraction. In histology, there was a reduction in the inflammatory infiltrate and increased gene expression of fibronectin and type III collagen, mainly in the CW + AV-GNPs group. The therapies were able to reduce pro-inflammatory cytokines, increase anti-inflammatory cytokines, and reduce oxidative stress. The results demonstrated that the effects of GNPs appear to complement those of the extracts, thereby enhancing the tissue repair process. [ABSTRACT FROM AUTHOR]

Published
2024
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14. 4-nitrochalcone exerts leishmanicidal effect on L. amazonensis promastigotes and intracellular amastigotes, and the 4-nitrochalcone encapsulation in beeswax copaiba oil nanoparticles reduces macrophages cytotoxicity

Author

Assolini, João Paulo, da Silva, Thais Peron, da Silva Bortoleti, Bruna Taciane, Gonçalves, Manoela Daiele, Tomiotto-Pellissier, Fernanda, Sahd, Claudia Stoeglehner, Carloto, Amanda Cristina Machado, Feuser, Paulo Emilio, Cordeiro, Arthur Poester, Sayer, Claudia, Hermes de Araújo, Pedro Henrique, Costa, Idessania Nazareth, Conchon-Costa, Ivete, Miranda-Sapla, Milena Menegazzo, and Pavanelli, Wander Rogério

Published
2020
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15. 2-methoxy-isobutyl-isonitrile-conjugated gold nanoparticles improves redox and inflammatory profile in infarcted rats

Author

Tartuce, Ludimilla Pereira, Pacheco Brandt, Fábio, dos Santos Pedroso, Giulia, Rezende Farias, Hemelin, Barros Fernandes, Bruna, da Costa Pereira, Bárbara, Gonçalves Machado, Alessandra, Feuser, Paulo Emílio, Lock Silveira, Paulo Cesar, Tiscoski Nesi, Renata, da Silva Paula, Marcos Marques, Andrades, Michael, and de Pinho, Ricardo Aurino

Published
2020
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18. Effects of phonophoresis with ibuprofen associated with gold nanoparticles in animal model of traumatic muscle injury

Author

Haupenthal, Daniela Pacheco dos Santos, Dias, Fernando Milanez, Zaccaron, Rubya Pereira, Silveira, Gustavo de Bem, Corrêa, Maria Eduarda Anastácio Borges, Mendes, Carolini, Casagrande, Laura de Roch, Pinho, Ricardo Aurino, de Andrade, Thiago Antonio Moretti, Feuser, Paulo Emilio, Paula, Marcos Marques da Silva, and Silveira, Paulo Cesar Lock

Published
2020
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20. Preparation and characterization of 4-nitrochalcone-folic acid-poly(methyl methacrylate) nanocapsules and cytotoxic activity on HeLa and NIH3T3 cells

Author

Carpio Arévalo, Juan Marcelo, Feuser, Paulo Emilio, Rossi, Gustavo Rodrigues, Trindade, Edvaldo S., da Silva Córneo, Emily, Machado-de-Ávila, Ricardo Andrez, Sayer, Claudia, Cadena, Silvia Maria Suter C., Noleto, Guilhermina Rodrigues, Martinez, Glaucia Regina, Hermes de Araújo, Pedro H., and Merlin Rocha, Maria Eliane

Published
2019
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24. Comparative cytotoxic effect of citrate-capped gold nanoparticles with different sizes on noncancerous and cancerous cell lines

Author

Vechia, Indiani Conti Della, Steiner, Bethina Trevisol, Freitas, Mauricio Lawrence, dos Santos Pedroso Fidelis, Giulia, Galvani, Nathalia Coral, Ronchi, Jonatha Moretto, Possato, Jonathann Corrêa, Fagundes, Mírian Ívens, Rigo, Flávia Karine, Feuser, Paulo Emilio, de Araújo, Pedro Henrique Hermes, and Machado-de-Ávila, Ricardo Andrez

Published
2020
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25. Green Synthesis of Gold Nanoparticles with Curcumin or Açai in the Tissue Repair of Palatal Wounds

Author

Thirupathi, Anand, primary, Guzzatti, Morgana Francisco Machado, additional, Corrêa, Maria Eduarda Anastácio Borges, additional, Venturini, Ligia Milanez, additional, Casagrande, Laura de Roch, additional, Lima, Igor Ramos, additional, Da Costa, Camila, additional, De Pieri, Ellen, additional, Tietbohl, Lariani Tamires Witt, additional, Feuser, Paulo Emilio, additional, Machado-de-Ávila, Ricardo Andrez, additional, Gu, Yaodong, additional, and Silveira, Paulo Cesar Lock, additional

Published
2023
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29. Mesoporous silica nanoparticles adsorb aflatoxin B1 and reduce mycotoxin-induced cell damage

Author

Savi, Geovana Dagostim, primary, Torres Zanoni, Elton, additional, Scussel, Rahisa, additional, Córneo, Emily da Silva, additional, Guimarães Furtado, Bianca, additional, Macuvele, Domingos Lusitâneo Pier, additional, Nones, Janaína, additional, Feuser, Paulo Emilio, additional, Machado-de-Ávila, Ricardo Andrez, additional, and Angioletto, Elidio, additional

Published
2022
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31. Peptide-Integrated Superparamagnetic Nanoparticles for the Identification of Epitopes from SARS-CoV-2 Spike and Nucleocapsid Proteins

Author

Scussel, Rahisa, primary, Feuser, Paulo Emilio, additional, Luiz, Gabriel Paulino, additional, Galvani, Nathalia Coral, additional, Fagundes, Mírian Ívens, additional, Gonçalves Dal-Bó, Alexandre, additional, Hermes de Araújo, Pedro Henrique, additional, Coelho, Eduardo Antônio Ferraz, additional, Chávez-Olórtegui, Carlos, additional, and Machado-de-Ávila, Ricardo Andrez, additional

Published
2022
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32. Effects of the intranasal application of gold nanoparticles on the pulmonary tissue after acute exposure to industrial cigarette smoke

Author

Porto, Germano Duarte, primary, Haupenthal, Daniela Pacheco dos Santos, additional, Souza, Priscila Soares, additional, Silveira, Gustavo de Bem, additional, Nesi, Renata Tiscoski, additional, Feuser, Paulo Emilio, additional, Possato, Jonathann Corrêa, additional, de Andrade, Vanessa Moraes, additional, Pinho, Ricardo Aurino, additional, and Silveira, Paulo Cesar Lock, additional

Published
2021
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34. Mesoporous silica nanoparticles adsorb aflatoxin B1 and reduce mycotoxin-induced cell damage.

Author

Savi, Geovana Dagostim, Torres Zanoni, Elton, Scussel, Rahisa, Córneo, Emily da Silva, Guimarães Furtado, Bianca, Macuvele, Domingos Lusitâneo Pier, Nones, Janaína, Feuser, Paulo Emilio, Machado-de-Ávila, Ricardo Andrez, and Angioletto, Elidio

Subjects
MESOPOROUS silica, AFLATOXINS, ADSORPTION capacity, DEOXYNIVALENOL, MYCOTOXINS, SILICA nanoparticles, SURFACE area
Abstract

The present study examined the effects of mesoporous silica nanoparticles (MSNs) on its adsorption capacity of aflatoxin B1 (AFB1). Moreover, the study evaluated the toxicity of MSNs with AFB1 using NIH3T3 cells and hemolysis test. The obtained MSNs were spherical, irregular-like in shape, having a mean size of 39.97 ± 7.85 nm and a BET surface area of 1195 m2/g. At 0.1 mg mL−1 concentration of MSN, the AFB1 adsorption capacity was 30%, which reached 70% when the MSN concentration increased to 2.0 mg mL−1. Our findings showed that AFB1 was adsorbed (∼67%) in the first few minutes on being in contact with MSNs, reaching an adsorption capacity of ∼70% after 15 min. Thereafter, the adsorption capacity remained constant in solution, demonstrating that the MSNs adsorbed toxins even beyond overnight. MSN treatment (0.5–2.0 mg mL−1) using NIH3T3 cells did not result in any reduction in cell viability. In addition, MSN treatment completely reversed the cytotoxic effect of AFB1 at all concentrations. Hemolysis test also revealed no hemolysis in MSNs evaluated alone and in those combined with AFB1. To the best of our knowledge, this study is the first to demonstrate that MSN can reduce cell toxicity produced by AFB1 due to its potential to adsorb mycotoxins. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Bovine Serum Albumin Conjugation in Superparamagnetic/Poly(methyl methacrylate) Nanoparticles as an Alternative for Magnetic Enzyme-Linked Immunosorbent Assays

Author

Feuser, Paulo Emilio, primary, Guindani, Camila, additional, Possato, Jonathann Correa, additional, Guessi, Jaqueline Pereira, additional, Cordeiro, Arthur Poester, additional, Machado-de-Ávila, Ricardo Andrez, additional, Sayer, Claudia, additional, and de Araújo, Pedro Henrique Hermes, additional

Published
2021
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36. Evaluation of the in vivo acute toxicity of poly(thioether‐ester) and superparamagnetic poly(thioether‐ester) nanoparticles obtained by thiol‐ene miniemulsion polymerization

Author

Feuser, Paulo Emilio, primary, Cardoso, Mariana de Melo, additional, Galvani, Nathalia Coral, additional, Zaccaron, Rubya Pereira, additional, Venturini, Ligia Milanez, additional, Rigo, Flavia Karine, additional, Machado‐de‐Ávila, Ricardo Andrez, additional, Silveira, Paulo Cesar Lock, additional, Sayer, Claudia, additional, and Hermes de Araújo, Pedro Henrique, additional

Published
2021
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37. Nanotechnology as a therapeutic strategy to prevent neuropsychomotor alterations associated with hypercholesterolemia

Author

Rodrigues, Matheus Scarpatto, primary, de Paula, Gabriela Cristina, additional, Duarte, Mariane Bernardo, additional, de Rezende, Victoria Linden, additional, Possato, Jonathann Correa, additional, Farias, Hemelin Resende, additional, Medeiros, Eduarda Behenck, additional, Feuser, Paulo Emilio, additional, Streck, Emilio Luiz, additional, de Ávila, Ricardo Andrez Machado, additional, Bast, Rachel Krolow Santos Silva, additional, Budni, Josiane, additional, de Bem, Andreza Fabro, additional, Silveira, Paulo César Lock, additional, and de Oliveira, Jade, additional

Published
2021
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38. Effects of the intranasal application of gold nanoparticles on the pulmonary tissue after acute exposure to industrial cigarette smoke.

Author

Porto, Germano Duarte, Haupenthal, Daniela Pacheco dos Santos, Souza, Priscila Soares, Silveira, Gustavo de Bem, Nesi, Renata Tiscoski, Feuser, Paulo Emilio, Possato, Jonathann Corrêa, de Andrade, Vanessa Moraes, Pinho, Ricardo Aurino, and Silveira, Paulo Cesar Lock

Subjects
CIGARETTE smoke, SMOKING, GOLD nanoparticles, CHRONIC obstructive pulmonary disease, CIGARETTE filters
Abstract

Inhalation of harmful particles appears as a primary factor for the onset and establishment of chronic obstructive pulmonary disease (COPD). Cigarette smoke acutely promotes an exacerbated inflammatory response with oxidative stress induction with DNA damage. Administration of Gold Nanoparticles (GNPs) with 20 nm in different concentrations can revert damages caused by external aggravations. The effects of GNPs in a COPD process have not been observed until now. The objective of this work was to evaluate the therapeutic effects of intranasal administration of different doses of GNPs after acute exposure to industrial cigarette smoke. Thirty male Swiss mice were randomly divided into five groups: Sham; cigarette smoke (CS); CS + GNPs 2.5 mg/L; CS + GNPs 7.5 mg/L and CS + GNPs 22.5 mg/L. The animals were exposed to the commercial cigarette with filter in an acrylic inhalation chamber and treated with intranasal GNPs for five consecutive days. The results demonstrate that exposure to CS causes an increase in inflammatory cytokines, histological changes, oxidative and nitrosive damage in the lung, as well as increased damage to the DNA of liver cells, blood plasma and lung. Among the three doses of GNPs (2.5, 7.5, and 22.5 mg/L) used, the highest dose had better anti‐inflammatory effects. However, GNPs at a dose of 7.5 mg/L showed better efficacies in reducing ROS formation, alveolar diameter, and the number of inflammatory cells in histology, in addition to significantly reduced rate of DNA damage in lung cells without additional systemic genotoxicity already caused by cigarette smoke. [ABSTRACT FROM AUTHOR]

Published
2022
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40. Effects of the Association between Photobiomodulation and Hyaluronic Acid Linked Gold Nanoparticles in Wound Healing

Author

Mendes, Carolini, primary, dos Santos Haupenthal, Daniela Pacheco, additional, Zaccaron, Rubya Pereira, additional, de Bem Silveira, Gustavo, additional, Corrêa, Maria Eduarda Anastácio Borges, additional, de Roch Casagrande, Laura, additional, de Sousa Mariano, Samara, additional, de Souza Silva, Jennyffer Ione, additional, de Andrade, Thiago Antônio Moretti, additional, Feuser, Paulo Emilio, additional, Machado-de-Ávila, Ricardo Andrez, additional, and Silveira, Paulo Cesar Lock, additional

Published
2020
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41. Antitumor activity associated with hyperthermia and 4-nitrochalcone loaded in superparamagnetic poly(thioether-ester) nanoparticles

Author

dos Santos, Paula Christina Mattos, primary, Feuser, Paulo Emilio, additional, Cordeiro, Arthur Poester, additional, Scussel, Rahisa, additional, Abel, Jessica da Silva, additional, Machado-de-Ávila, Ricardo Andrez, additional, Rocha, Maria Eliane Merlin, additional, Sayer, Claudia, additional, and Hermes de Araújo, Pedro Henrique, additional

Published
2020
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42. Diethyldithiocarbamate encapsulation reduces toxicity and promotes leishmanicidal effect through apoptosis-like mechanism in promastigote and ROS production by macrophage

Author

Assolini, João Paulo, primary, Tomiotto-Pellissier, Fernanda, additional, da Silva Bortoleti, Bruna Taciane, additional, Gonçalves, Manoela Daiele, additional, Sahd, Claudia Stoeglehner, additional, Carloto, Amanda Cristina Machado, additional, Feuser, Paulo Emilio, additional, Cordeiro, Arthur Poester, additional, Borghi, Sergio Marques, additional, Verri, Waldiceu Aparecido, additional, Sayer, Claudia, additional, Hermes de Araújo, Pedro Henrique, additional, Costa, Idessania Nazareth, additional, Conchon-Costa, Ivete, additional, Miranda-Sapla, Milena Menegazzo, additional, and Pavanelli, Wander Rogério, additional

Published
2020
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43. In vitro cytotoxicity and hyperthermia studies of superparamagnetic poly(urea-urethane) nanoparticles obtained by miniemulsion polymerization in human erythrocytes and NIH3T3 and HeLa cells

Author

Feuser, Paulo Emilio, primary, Chiaradia, Viviane, additional, Galvani, Nathalia Coral, additional, Scussel, Rahisa, additional, Machado-de-Ávila, Ricardo Andrez, additional, de Oliveira, Débora, additional, Hermes de Araújo, Pedro H., additional, and Sayer, Claudia, additional

Published
2020
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44. Evaluation of the in vivo acute toxicity of poly(thioether‐ester) and superparamagnetic poly(thioether‐ester) nanoparticles obtained by thiol‐ene miniemulsion polymerization.

Author

Feuser, Paulo Emilio, Cardoso, Mariana de Melo, Galvani, Nathalia Coral, Zaccaron, Rubya Pereira, Venturini, Ligia Milanez, Rigo, Flavia Karine, Machado‐de‐Ávila, Ricardo Andrez, Silveira, Paulo Cesar Lock, Sayer, Claudia, and Hermes de Araújo, Pedro Henrique

Subjects
MAGNETIC nanoparticles, NANOPARTICLES, POLYMERIZATION, SURFACE charges, LABORATORY mice
Abstract

Poly(thioether‐ester) (PTEe) nanoparticles obtained by thiol‐ene polymerization have received attention of many researchers due to several advantages, including, biocompatibility and biodegradability. The search for new nanomaterials requires toxicity studies to assess potential toxic effects of their administration. Therefore, the aim of this study was to evaluate the in vivo acute toxicity of PTEe and poly(thioether‐ester)‐coated magnetic nanoparticles prepared by thiol‐ene polymerization in miniemulsion. These nanoparticles presented a mean size of approximately 120 nm, spherical morphology, and negative surface charge. Doses of 40 mg/kg were administered intraperitoneally to Swiss mice and nociceptive, behavioral and biochemical parameters were investigated in five different organs. None of the nanoparticles led to any alterations in the nociceptive and behavioral responses. Biochemical alterations were observed in liver, decreasing the sulfhydryl and glutathione (GSH) levels, suggesting the dependence of the GSH metabolism in the elimination of the nanoparticles. In general, both nanoparticle types did not cause disturbances in biochemical parameters analyzed in others organs. These results suggest that both nanoparticle types did not induce acute toxicity to the different organs evaluated, reinforcing the biocompatibility of PTEe nanoparticles synthetized by thiol‐ene polymerization. [ABSTRACT FROM AUTHOR]

Published
2022
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45. In Vitro Cytotoxicity of Poly(Methyl Methacrylate) Nanoparticles and Nanocapsules Obtained by Miniemulsion Polymerization for Drug Delivery Application

Author

Sayer Claudia, DE Araujo Pedro Henrique Hermes, Dos Santos Silva Maria Claudia, Dos Santos Bubniak Lorena, Feuser Paulo Emilio, Ricci-Junior Eduardo, Bodack Camila do Nascimento, and Valerio Alexsandra

Subjects
Materials science, In vitro cytotoxicity, Biomedical Engineering, Nanoparticle, Bioengineering, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Poly(methyl methacrylate), Nanocapsules, 0104 chemical sciences, Miniemulsion, Polymerization, Chemical engineering, visual_art, Polymer chemistry, Drug delivery, visual_art.visual_art_medium, General Materials Science, 0210 nano-technology
Published
2016
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47. Effects of chronic treatment with gold nanoparticles on inflammatory responses and oxidative stress in Mdx mice

Author

Haupenthal, Daniela Pacheco dos Santos, primary, Possato, Jonathann Corrêa, additional, Zaccaron, Rubya Pereira, additional, Mendes, Carolini, additional, Rodrigues, Matheus Scarpatto, additional, Nesi, Renata Tiscoski, additional, Pinho, Ricardo Aurino, additional, Feuser, Paulo Emilio, additional, Machado-de-Ávila, Ricardo Andrez, additional, Comim, Clarissa M., additional, and Silveira, Paulo Cesar Lock, additional

Published
2019
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49. In vitro cytotoxicity and hyperthermia studies of superparamagnetic poly(urea-urethane) nanoparticles obtained by miniemulsion polymerization in human erythrocytes and NIH3T3 and HeLa cells.

Author

Feuser, Paulo Emilio, Chiaradia, Viviane, Galvani, Nathalia Coral, Scussel, Rahisa, Machado-de-Ávila, Ricardo Andrez, de Oliveira, Débora, Hermes de Araújo, Pedro H., and Sayer, Claudia

Subjects
*FEVER, *ERYTHROCYTES, *MAGNETIC nanoparticles, *HELA cells, *NANOPARTICLES, *POLYMERIZATION, *EMULSIONS (Pharmacy), *FOOD emulsions
Abstract

In this work, magnetic nanoparticles were encapsulated in PUU by miniemulsion polymerization resulting in particles with an average diameter of 164 nm and superparamagnetic proprieties. The hemocompatibility was confirmed by hemolysis and flow cytometry analyses. When an AC magnetic field was applied under superparamagnetic PUU nanoparticles the temperature reached the threshold temperature required for cancer hyperthermia, decreasing the HeLa cells viability at all concentrations tested. On the other hand, when the NIH3T3 cells were submitted to hyperthermia no cytotoxic effect was observed. In particular, the hyperthermia assay proved to be effective in destroying cancer cells while preserving non-tumor ones. [ABSTRACT FROM AUTHOR]

Published
2021
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