298 results on '"Feuillard, J"'
Search Results
2. P594: INCREASED FREQUENCIES OF IGH LOCUS SUICIDE RECOMBINATION POINTS ON CHRONIC LYMPHOCYTIC LEUKEMIA WITH LOW RATE OF AID RELATED SOMATIC MUTATIONS, MYC OVEREXPRESSION AND SHORT TELOMERES
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Al Jamal, I., primary, Parquet, M., additional, Boutouil, H., additional, Guiyedi, K., additional, Rizzo, D., additional, Dupont, M., additional, Boulin, M., additional, Aoufouchi, S., additional, Al Hamaoui, S., additional, Makdissy, N., additional, Feuillard, J., additional, Gachard, N., additional, and Peron, S., additional
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- 2022
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3. P1285: IN VIVO IMPACT OF ABERRANT OVEREXPRESSION OF C-REL NF-ΚB SUBUNIT IN GERMINAL CENTER B-LYMPHOCYTES: A TUMOR ONCOGENIC EVENT IN GCB-DLBCLS
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Prévaud, L., primary, Vincent-Fabert, C., additional, Feuillard, J., additional, and Faumont, N., additional
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- 2022
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4. A novel t(3;13)(q13;q12) translocation fusing FLT3 with GOLGB1: toward myeloid/lymphoid neoplasms with eosinophilia and rearrangement of FLT3?
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Troadec, E, Dobbelstein, S, Bertrand, P, Faumont, N, Trimoreau, F, Touati, M, Chauzeix, J, Petit, B, Bordessoule, D, Feuillard, J, Bastard, C, and Gachard, N
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- 2017
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5. IgM peak independently predicts treatment-free survival in chronic lymphocytic leukemia and correlates with accumulation of adverse oncogenetic events
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Rizzo, D, Chauzeix, J, Trimoreau, F, Woillard, J B, Genevieve, F, Bouvier, A, Labrousse, J, Poli, C, Guerin, E, Dmytruk, N, Remenieras, L, Feuillard, J, and Gachard, N
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- 2015
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6. RelA and RelB cross-talk and function in Epstein–Barr virus transformed B cells
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Chanut, A, Duguet, F, Marfak, A, David, A, Petit, B, Parrens, M, Durand-Panteix, S, Boulin-Deveza, M, Gachard, N, Youlyouz-Marfak, I, Bordessoule, D, Feuillard, J, and Faumont, N
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- 2014
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7. IGHV gene features and MYD88 L265P mutation separate the three marginal zone lymphoma entities and Waldenström macroglobulinemia/lymphoplasmacytic lymphomas
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Gachard, N, Parrens, M, Soubeyran, I, Petit, B, Marfak, A, Rizzo, D, Devesa, M, Delage-Corre, M, Coste, V, Laforêt, M P, de Mascarel, A, Merlio, J P, Bouabdhalla, K, Milpied, N, Soubeyran, P, Schmitt, A, Bordessoule, D, Cogné, M, and Feuillard, J
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- 2013
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8. Standardization of flow cytometry in myelodysplastic syndromes: a report from an international consortium and the European LeukemiaNet Working Group
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Westers, T M, Ireland, R, Kern, W, Alhan, C, Balleisen, J S, Bettelheim, P, Burbury, K, Cullen, M, Cutler, J A, Della Porta, M G, Dräger, A M, Feuillard, J, Font, P, Germing, U, Haase, D, Johansson, U, Kordasti, S, Loken, M R, Malcovati, L, te Marvelde, J G, Matarraz, S, Milne, T, Moshaver, B, Mufti, G J, Ogata, K, Orfao, A, Porwit, A, Psarra, K, Richards, S J, Subirá, D, Tindell, V, Vallespi, T, Valent, P, van der Velden, V H J, de Witte, T M, Wells, D A, Zettl, F, Béné, M C, and van de Loosdrecht, A A
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- 2012
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9. Splenic marginal zone lymphomas and lymphoplasmacytic lymphomas originate from B-cell compartments with two different antigen-exposure histories
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Parrens, M, Gachard, N, Petit, B, Marfak, A, Troadec, E, Bouabdhalla, K, Milpied, N, Merlio, J P, de Mascarel, A, Laurent, C, Soubeyran, I, Coste, V, Labrousse, F, Cogné, M, and Feuillard, J
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- 2008
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10. Mass cytometry and artificial intelligence define CD169 as a specific marker of SARS-CoV2-induced acute respiratory distress syndrome
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Roussel, M., primary, Ferrant, J., additional, Reizine, F., additional, Le Gallou, S., additional, Dulong, J., additional, Carl, S., additional, Lesouhaitier, M., additional, Gregoire, M., additional, Bescher, N., additional, Verdy, C., additional, Latour, M., additional, Bézier, I., additional, Cornic, M., additional, Leonard, S., additional, Feuillard, J., additional, Tiwari, V.K., additional, Tadié, J.M., additional, Cogné, M., additional, and Tarte, K., additional
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- 2020
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11. NXF1 and CRM1 nuclear export pathways orchestrate nuclear export, translation and packaging of murine leukaemia retrovirus unspliced RNA
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Mougel, M., primary, Akkawi, C., additional, Chamontin, C., additional, Feuillard, J., additional, Pessel-Vivares, L., additional, Socol, M., additional, and Laine, S., additional
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- 2020
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12. Multicentric evaluation of the MDR phenotype in leukemia
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Marie, J-P, Huet, S, Faussat, A-M, Perrot, J-Y, Chevillard, S, Barbu, V, Bayle, C, Boutonnat, J, Calvo, F, Campos-Guyotat, L, Colosetti, P, Cazin, J-L, de Cremoux, P, Delvincourt, C, Demur, C, Drenou, B, Fenneteau, O, Feuillard, J, Garnier-Suillerot, A, Genne, P, Gorisse, M-C, Gosselin, P, Jouault, H, Lacave, R, Le Calvez, G, Léglise, M-C, Léonce, S, Manfait, M, Maynadié, M, Merle-Béral, H, Merlin, J-L, Mousseau, M, Morjani, H, Picard, F, Pinguet, F, Poncelet, P, Racadot, E, Raphael, M, Richard, B, Rossi, J-F, Schlegel, N, Vielh, P, Zhou, D-C, and Robert, J
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- 1997
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13. Comparative study ofin vitro inhibition of activation of the classical and alternative pathways of human complement by the magnesium and sodium salts of the anti-inflammatory peptide N-acetyl-aspartyl-glutamic acid (NAAGA)
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Feuillard, J., Maillet, F., Goldschmidt, P., Weiss, L., and Kazatchkine, M. D.
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- 1991
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14. C-REL NF-KAPPA B SUBUNIT ACTIVITY REFINES A DISTINCT GERMINAL CENTER DIFFUSE LARGE B-CELL LYMPHOMA SUBGROUP WITH FAVORABLE OUTCOME
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Faumont, N., primary, Taoui, O., additional, Collares, D., additional, Jais, J.-P., additional, Leroy, K., additional, Jardin, F., additional, Molina, T., additional, Baud, V., additional, and Feuillard, J., additional
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- 2019
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15. PF520 C-REL NF-KAPPA B SUBUNIT ACTIVITY REFINES A DISTINCT GERMINAL CENTER DIFFUSE LARGE B-CELL LYMPHOMA SUBGROUP WITH FAVORABLE OUTCOME
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Faumont, N., primary, Taoui, O., additional, Collares, D., additional, Jais, J.-P., additional, Leroy, K., additional, Jardin, F., additional, Molina, T., additional, Baud, V., additional, and Feuillard, J., additional
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- 2019
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16. PS1138 TUMOR MUTATIONAL BURDEN ASSESSED BY TARGETED HIGH THROUGHPUT SEQUENCING PREDICTS TREATMENT FREE SURVIVAL IN CLL: RESULTS FROM A BICENTER STUDY
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Chauzeix, J., primary, Pastoret, C., additional, Donaty, L., additional, Gachard, N., additional, Fest, T., additional, Feuillard, J., additional, and Rizzo, D., additional
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- 2019
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17. PB2057 PRE-CLINICAL BLOCKING OF PD-L1 MOLECULE, WHICH EXPRESSION IS DOWN REGULATED BY NF-κB, JAK1/JAK2 AND BTK INHIBITORS, INDUCES REGRESSION OF ACTIVATED B-CELL LYMPHOMA
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Vincent-Fabert, C., primary, Roland, L., additional, Zimber-Strobl, U., additional, Feuillard, J., additional, and Faumont, N., additional
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- 2019
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18. ANALYSIS OF THE MYELOID PANEL OF THE VI WORKSHOP ON 26 CASES OF ACUTE MYELOBLASTIC LEUKEMIA: MC-6-10
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Faure, G C, Bernier, M, Bourin, Ph, Campos, L, Casasnovas, O, Falkenrodt, A, Favre, M, Feuillard, J, Firat, H, Garand, R, Jacob, M C, Jouault, H, Kolopp-Sarda, M N, Kuhlein, E, Lavabre, C, Lenormand, B, Moskowchenko, Ph, Raphael, M, Robillard, N, Sabido, O, Taïb, J, and Béné, M C
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- 1996
19. TESTS OF MONOCLONAL ANTIBODIES TO CD95, CD120A AND CD120B IN IMMUNOHISTOCHEMISTRY LABELLING: CR-6-15
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Legendre, C., Raphaël, M., Feuillard, J., Gras, G., Richard, Y., and Dormont, D.
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- 1996
20. Immunophenotypic analysis of erythroid dysplasia in myelodysplastic syndromes. A report from the IMDSFlow working group
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Westers, T.M. (Theresia), Cremers, E.M.P. (Eline), Oelschlaegel, U. (Uta), Johansson, U. (Ulrika), Bettelheim, P. (Peter), Matarraz, S. (S.), Orfao, A. (Alberto), Moshaver, B. (Bijan), Brodersen, L.E. (Lisa Eidenschink), Loken, M.R. (Michael), Wells, D.A. (Denise), Subirá, D. (Dolores), Cullen, C., Marvelde, J.G. (Jeroen) te, Velden, V.H.J. (Vincent) van der, Preijers, F.W.M.B. (Frank), Chu, S.-C. (Sung-Chao), Feuillard, J. (Jean), Guérin, E. (Estelle), Psarra, K. (Katherina), Porwit, A. (Anna), Saft, L. (Leonie), Ireland, R. (Robin), Milne, T. (Timothy), Béné, M.C., Witte, B.I. (Birgit), Della Porta, M.G. (Matteo), Kern, W. (Wolfgang), Loosdrecht, A.A. (Arjan) van de, Westers, T.M. (Theresia), Cremers, E.M.P. (Eline), Oelschlaegel, U. (Uta), Johansson, U. (Ulrika), Bettelheim, P. (Peter), Matarraz, S. (S.), Orfao, A. (Alberto), Moshaver, B. (Bijan), Brodersen, L.E. (Lisa Eidenschink), Loken, M.R. (Michael), Wells, D.A. (Denise), Subirá, D. (Dolores), Cullen, C., Marvelde, J.G. (Jeroen) te, Velden, V.H.J. (Vincent) van der, Preijers, F.W.M.B. (Frank), Chu, S.-C. (Sung-Chao), Feuillard, J. (Jean), Guérin, E. (Estelle), Psarra, K. (Katherina), Porwit, A. (Anna), Saft, L. (Leonie), Ireland, R. (Robin), Milne, T. (Timothy), Béné, M.C., Witte, B.I. (Birgit), Della Porta, M.G. (Matteo), Kern, W. (Wolfgang), and Loosdrecht, A.A. (Arjan) van de
- Abstract
Current recommendations for diagnosing myelodysplastic syndromes endorse flow cytometry as an informative tool. Most flow cytometry protocols focus on the analysis of progenitor cells and the evaluation of the maturing myelomonocytic lineage. However, one of the most frequently observed features of myelodysplastic syndromes is anemia, which may be associated with dyserythropoiesis. Therefore, analysis of changes in flow cytometry features of nucleated erythroid cells may complement current flow cytometry tools. The multicenter study within the IMDSFlow Working Group, reported herein, focused on defining flow cytometry parameters that enable discrimination of dyserythropoiesis associated with myelodysplastic syndromes from non-clonal cytopenias. Data from a learning cohort were compared between myelodysplasia and controls, and results were validated in a separate cohort. The learning cohort comprised 245 myelodysplasia cases, 290 pathological, and 142 normal controls; the validation cohort comprised 129 myelodysplasia cases, 153 pathological, and 49 normal controls. Multivariate logistic regression analysis performed in the learning cohort revealed that analysis of expression of CD36 and CD71 (expressed as coefficient of variation), in combination with CD71 fluorescence intensity and the percentage of CD117+ erythroid progenitors provided the best discrimination between myelodysplastic syndromes and non-clonal cytopenias (specificity 90%; 95% confidence interval: 84–94%). The high specificity of this marker set was confirmed in the validation cohort (92%; 95% confidence interval: 86–97%). This erythroid flow cytometry marker combination may improve the evaluation of cytopenic cases with suspected myelodysplasia, particularly when combined with flow cytometry assessment of the myelomonocytic lineage.
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- 2017
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21. DLBCL-derived exosomes : a new link between TrkB and rituximab sensitivity ?
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Bentayeb, H., Branchaud, M., Aitamer, M., Magnaudeix, A., Heang Ly, K., Feuillard, J., Bordessoule, D, Jauberteau, Isabelle, Troutaud, D., Axe 2 : procédés plasmas et lasers (SPCTS-AXE2), Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM), and DERORY, BEATRICE
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[CHIM.MATE] Chemical Sciences/Material chemistry ,[CHIM.MATE]Chemical Sciences/Material chemistry ,[SPI.MAT] Engineering Sciences [physics]/Materials ,ComputingMilieux_MISCELLANEOUS ,[SPI.MAT]Engineering Sciences [physics]/Materials - Abstract
International audience
- Published
- 2016
22. Mutational Analysis of MDS and AML Occurring after Treatment for Acute Promyelocytic Leukemia (APL). A Report of 9 Cases
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Attias, P., primary, Renneville, A., additional, Thomas, X., additional, Bally, C., additional, Hayette, S., additional, Farhat, H., additional, Eclache, V., additional, Marceau, A., additional, Cassinat, B., additional, Feuillard, J., additional, Terre, C., additional, Delabesse, E., additional, Park, S., additional, Lejeune, S., additional, Chevret, S., additional, Ades, L., additional, Preudhomme, C., additional, and Fenaux, P., additional
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- 2017
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23. French Intensive Care Society, International congress - Réanimation 2016
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Jaillette, E, Girault, C, Brunin, G, Zerimech, F, Chiche, A, Broucqsault Dedrie, C, Fayolle, C, Minacori, F, Alves, I, Barrailler, S, Robriquet, L, Delaporte, E, Thellier, D, Delcourte, C, Duhamel, A, Nseir, S, Valette, X, Desmeulles, I, Savary, B, Masson, R, Seguin, A, Daubin, C, Sauneuf, B, Verrier, P, Pottier, V, Orabona, M, Samba, D, Viquesnel, G, Lermuzeaux, M, Hazera, P, Hanouz, J, Parienti, J, Du Cheyron, D, Demoule, A, Clavel, M, Rolland Debord, C, Perbet, S, Terzi, N, Kouatchet, A, Wallet, F, Roze, H, Vargas, F, Guérin, C, Dellamonica, J, Jaber, S, Similowski, T, Quenot, J, Binquet, C, Vinsonneau, C, Barbar, S, Vinault, S, Deckert, V, Lemaire, S, Hssain, A, Bruyère, R, Souweine, B, Lagrost, L, Adrie, C, Jung, B, Daurat, A, De Jong, A, Chanques, G, Mahul, M, Monnin, M, Molinari, N, Lheureux, O, Trepo, E, Hites, M, Cotton, F, Wolff, F, Surin, R, Créteur, J, Vincent, J, Gustot, T, Jacobs, F, Taccone, F, Neuville, M, Timsit, J, El Helali, N, Le Monnier, A, Magalhaes, E, Radjou, A, Smonig, R, Soubirou, J, Voiriot, G, Sonneville, R, Bouadma, L, Mourvillier, B, Gélisse, E, Brasseur, A, Roisin, S, De Backer, D, Van Ruychevelt, V, Carlier, E, Piagnerelli, M, Vanhaeverbeek, M, Danguy, C, Biston, P, Au, S, Begot, E, Dalmay, F, Repessé, X, Prat, G, Bouferrache, K, Slama, M, Vieillard Baron, A, Monnet, X, Marik, P, Teboul, J, Jozwiak, M, Richard, C, Chauvet, J, El Dash, S, Delastre, O, Bouffandeau, B, Jusserand, D, Michot, J, Bauer, F, Brazier, F, Mercado, P, Kontar, L, Titeca, D, De Cagny, B, Bacari Risal, G, Riviere, A, Maizel, J, Guillot, C, Le Reun, C, Lampin, M, Sadik, A, Botte, A, Leteurtre, S, Collins, A, Kempeneers, C, Cajgfinger, N, Ohlmann, C, Pouyau, R, Subtil, F, Baudin, F, Massenavette, B, Javouhey, E, Milesi, C, Essouri, S, Liet, J, Afanetti, M, Durand, S, Durand, P, Roze, J, Dupont, D, Cambonie, G, Soyer, B, Rusca, M, Lukaszewicz, A, Crassard, I, Guichard, J, Bresson, D, de la Garanderie, D, Cantier, M, Sabben, C, Louedec, L, Delbosc, S, Journé, C, Ou, P, Klein, I, Chau, F, Lefort, A, Desilles, J, Michel, J, Mazighi, M, Salem, O, Demeret, S, Bolgert, F, Sharshar, T, Grabli, D, Arib, S, Crippa, I, Soummer, A, Engrand, N, Guedin, P, Aldea, S, Cerf, C, Desailly, V, Pasquier, P, Brun, P, Roux, D, Latournerie, G, Kasprzyk, L, Grosjean, V, Latreche, A, Habert, P, Huot, S, Jobin, T, Tesnière, A, Dreyfuss, D, Ricard, J, Mignon, A, Gaudry, S, Laithier, F, Kimmoun, A, Chouihed, T, Albizzati, S, Camenzind, E, Vanhuyse, F, Levy, B, Cour, M, Venet, F, Hernu, R, Demaret, J, Monneret, G, Argaud, L, Dumas, F, Lamhaut, L, Rosencher, J, Pène, F, Varenne, O, Carli, P, Jouven, X, Spaulding, C, Cariou, A, Geri, G, Bonnetain, F, Marijon, E, Empana, J, Mirouse, A, Resche Rigon, M, Mayaux, J, Rabbat, A, Meert, A, Benoit, D, Bruneel, F, Azoulay, E, Dupuis, C, Schwebel, C, Ruckly, S, Goldgran Toledano, D, Marcotte, G, Lafarge, A, Pichereau, C, Theodose, I, Scotto, M, Kemlin, D, Ghrenassia, E, Schlemmer, B, Vimpere, D, Galicier, L, Contou, D, Guérot, E, Grimaldi, D, Ricome, S, Maury, E, Plantefève, G, Dessap, A, Brun Buisson, C, de Prost, N, Dubé, B, Delemazure, J, Dres, M, Rousseau, L, Drouot, X, Diaz, V, Rebollar, Y, Frat, J, Thille, A, Aissa, D, Coquet, P, Ruiz, J, Ferre, F, Hoarau, L, Riu Poulenc, B, Bataille, B, Silva, S, Baudel, J, Bigé, N, Tahiri, J, Dubée, V, Guidet, B, Ait Oufella, H, Jinglun, L, Shen, F, Bailly, S, Leroy, O, Montravers, P, Constantin, J, Dupont, H, Guillemot, D, Lortholary, O, Perrigault, P, Gangneux, J, Razazi, K, Mekontso Dessap, A, Jansen, C, Lecronier, M, Sandrine, V, Mira, J, Blein, S, Marin, N, Rousseau, C, Charpentier, J, Pachot, A, Hraiech, S, Bordes, J, De, L, Mège, J, Forel, J, Guervilly, C, Adda, M, Raoult, D, Papazian, L, Kentish Barnes, N, Cohen Solal, Z, Souppart, V, Kerhuel, L, Haubertin, C, Exbrayat, I, Rozières, E, Argain, A, Suc, A, Vignes, M, Cougot, P, Fourcade, O, Brunel, E, Messika, J, Tubach, F, Dubief, E, Pasquet, B, Guillo, S, Pierron, C, Grimaud, M, Farnoux, C, Maillard, A, Decavèle, M, Prodanovic, H, Idbaih, A, Alentorn, A, Delattre, J, De Montmollin, E, Brule, N, Conrad, M, Dailler, F, Navellou, J, Alves, M, Tonnelier, J, Picard, G, Rogemond, V, Honnorat, J, Marzorati, C, Lebert, C, Perez, P, Citerio, G, Legriel, S, Tripon, S, Mallet, M, Rudler, M, Imbert Bismut, F, Thabut, D, Canet, E, Faguer, S, Moreau, A, Barbier, F, Merceron, S, Guitton, C, Labadie, F, Lemiale, V, Faucher, E, Klouche, K, Chevret, S, Ragot, S, Coudroy, R, Boulain, T, Jamet, A, Mercat, A, Brochard, L, Roux, A, Franchineau, G, Brechot, N, Lebreton, G, Hekimian, G, Nieszkowska, A, Leprince, P, Trouillet, J, Combes, A, Schmidt, M, Barrot, L, Piton, G, Bailey, M, Panwar, R, Belin, N, Belon, F, Patry, C, Grandperrin, M, Chaignat, C, Labro, G, Vivet, B, Capellier, G, Daix, T, Guérin, E, Tavernier, E, Mercier, E, Gissot, V, Vallejo, C, François, B, Ravry, C, Pichon, N, Chapellas, C, Fedou, A, Galy, A, Ploy, M, Barraud, O, Vignon, P, Thooft, A, Conotte, R, Colet, J, Le Dorze, M, Tarazona, V, Brumpt, C, 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Nativel, B, Planesse, C, Diotel, N, Meilhac, O, Roy Gash, F, Lebard, C, Larbi, A, Gaudin, V, Bonnin, F, Sultan, O, Hoc, C, Mathieu, E, Lapergue, B, Bourdain, F, Caron, M, Parrot, A, Labbe, V, Hafiani, E, Quesnel, C, Genay, S, Décaudin, B, Ethgen, S, Odou, P, Lebuffe, G, Mcquilte, Z, Allaouchiche, B, Verdière, B, Nyunga, M, Banaias, N, Colling, D, Kauv, M, Blondeau, E, Auclin, E, Haw Berlemont, C, Taieb, J, Oudard, S, Morissette, G, Kechaou, W, Litalien, C, Merouani, A, Phan, V, Bouchard, J, Starck, J, Briand, N, Sachs, P, Angoulvant, F, Sommet, J, Holvoet, L, Benkerrou, M, Dreyfus, L, Bordet, F, Touzet, S, Denis, A, Le Coz, J, Chéron, G, Nabbout, R, Patteau, G, Heilbronner, C, Hubert, P, Oualha, M, Crulli, B, Toledano, B, Poirier, N, Vobecky, S, Khouadja, H, Vinet, M, Vinclair, C, Beloncle, F, Radermacher, P, Asfar, P, Coupez, E, Bohé, J, Shinotsuka, C, Caironi, P, Villois, P, Fontana, V, Creteur, J, Pourcine, F, Vong, L, Weyer, C, Akando, B, Abdallah, R, Wetzstein, M, Antier, N, Serroukh, Y, Boudjeltia, K, Joosten, A, Rousseau, A, Delabranche, X, Grunebaum, L, Mootien, Y, Gaci, R, Garric, J, Delbove, A, Darreau, C, Dargent, A, Soudry Faure, A, De Chambrun, M, Demondion, P, Blanchard, J, Chocron, S, Meneveau, N, Corsi, F, Meynieu, P, Repusseau, B, Germain, A, Baudry, G, Hierle, L, Besch, G, Thomas, G, Cassir, N, Dizier, S, Roch, A, Trebbia, G, Govindaradjou, K, Devaquet, J, Picard, C, Parquin, F, Leguen, M, Felten, M, Sage, E, Chapelier, A, Duruisseaux, M, Fleury, J, Antoine, M, Carette, M, Wislez, M, Givel, C, De Margerie Mellon, C, De Kerviler, E, Tandjaoui Lambiotte, Y, Freynet, O, Baux, E, Das, V, Talec, P, Anguel, N, Louis, G, Girerd, N, Tallon, P, Hadchouel Duvergé, A, Salvi, N, Cairet, P, Delacourt, C, Blandine, B, Beraud, L, Lamaziere, A, Lionnet, F, Lehingue, S, D'Journo, X, Jean Marie, F, Thibault, R, Makhlouf, A, Mulliez, A, Dadet, S, Kekstas, G, Preiser, J, Rotovnik, K, Rozalen, I, Kupczyk, K, Krznaric, Z, Cano, N, Pichard, C, Le Roux, B, Jotterand, 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Elkhawand, C, Vermeesh, F, Vermeesh, F., and CITERIO, GIUSEPPE
- Abstract
Determinants of outcome in critically ill patients with hematological malignancy and central neurological failure: data from the TRIAL OH study
- Published
- 2016
24. A novel t(3;13)(q13;q12) translocation fusing FLT3 with GOLGB1: toward myeloid/lymphoid neoplasms with eosinophilia and rearrangement of FLT3?
- Author
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Troadec, E, primary, Dobbelstein, S, additional, Bertrand, P, additional, Faumont, N, additional, Trimoreau, F, additional, Touati, M, additional, Chauzeix, J, additional, Petit, B, additional, Bordessoule, D, additional, Feuillard, J, additional, Bastard, C, additional, and Gachard, N, additional
- Published
- 2016
- Full Text
- View/download PDF
25. Diagnosis and management of disorders that can mimic lymphoma
- Author
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Dispenzieri, A., Pittaluga, S., Facchetti, Fabio, Feuillard, J., and Jaffe, E. S.
- Subjects
Leukemia ,Plasmacytoid Dendritic Cells ,Neoplasms ,Immunohistochemistry - Published
- 2010
26. La cellule d’origine du lymphome cutané B diffus à grandes cellules de type jambe : un lymphocyte B mature, post centre germinatif
- Author
-
Pham-Ledard, A., primary, Prochazkova-Carlotti, M., additional, Deveza, M., additional, Beylot-Barry, M., additional, Vergier, B., additional, Parrens, M., additional, Merlio, J.-P., additional, Feuillard, J., additional, and Gachard, N., additional
- Published
- 2014
- Full Text
- View/download PDF
27. 269 - Mutational Analysis of MDS and AML Occurring after Treatment for Acute Promyelocytic Leukemia (APL). A Report of 9 Cases
- Author
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Attias, P., Renneville, A., Thomas, X., Bally, C., Hayette, S., Farhat, H., Eclache, V., Marceau, A., Cassinat, B., Feuillard, J., Terre, C., Delabesse, E., Park, S., Lejeune, S., Chevret, S., Ades, L., Preudhomme, C., and Fenaux, P.
- Published
- 2017
- Full Text
- View/download PDF
28. Intérêt diagnostic de la cytométrie en flux en chirurgie cardiaque
- Author
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Daix, T., primary, Guérin, E., additional, Gautier, F., additional, Marsaud, J.-P., additional, Piccardo, A., additional, Woilard, J.-B., additional, Feuillard, J., additional, and François, B., additional
- Published
- 2014
- Full Text
- View/download PDF
29. IgM peak independently predicts treatment-free survival in chronic lymphocytic leukemia and correlates with accumulation of adverse oncogenetic events
- Author
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Rizzo, D, primary, Chauzeix, J, additional, Trimoreau, F, additional, Woillard, J B, additional, Genevieve, F, additional, Bouvier, A, additional, Labrousse, J, additional, Poli, C, additional, Guerin, E, additional, Dmytruk, N, additional, Remenieras, L, additional, Feuillard, J, additional, and Gachard, N, additional
- Published
- 2014
- Full Text
- View/download PDF
30. Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exogenous activation of JNK and p38 MAP kinases
- Author
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Farhat, M, primary, Poissonnier, A, additional, Hamze, A, additional, Ouk-Martin, C, additional, Brion, J-D, additional, Alami, M, additional, Feuillard, J, additional, and Jayat-Vignoles, C, additional
- Published
- 2014
- Full Text
- View/download PDF
31. Rationale for the clinical application of flow cytometry in patients with myelodysplastic syndromes: position paper of an International Consortium and the European LeukemiaNet Working Group
- Author
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Loosdrecht, A.A. van de, Ireland, R., Kern, W., Della Porta, M.G., Alhan, C., Balleisen, J.S., Bettelheim, P., Bowen, D.T., Burbury, K., Eidenschink, L., Cazzola, M., Chu, S.S., Cullen, M., Cutler, J.A., Drager, A.M., Feuillard, J., Fenaux, P., Font, P., Germing, U., Haase, D., Hellstrom-Lindberg, E., Johansson, U., Kordasti, S., Loken, M.R., Malcovati, L., Marvelde, J.G. Te, Matarraz, S., Milne, T., Moshaver, B., Mufti, G.J., Nikolova, V., Ogata, K., Oelschlaegel, U., Orfao, A., Ossenkoppele, G.J., Porwit, A., Platzbecker, U., Preijers, F.W.M.B., Psarra, K., Richards, S.J., Subira, D., Seymour, J.F., Tindell, V., Vallespi, T., Valent, P., Velden, V.H. van der, Wells, D.A., Witte, T.J.M. de, Zettl, F., Bene, M.C., Westers, T.M., Loosdrecht, A.A. van de, Ireland, R., Kern, W., Della Porta, M.G., Alhan, C., Balleisen, J.S., Bettelheim, P., Bowen, D.T., Burbury, K., Eidenschink, L., Cazzola, M., Chu, S.S., Cullen, M., Cutler, J.A., Drager, A.M., Feuillard, J., Fenaux, P., Font, P., Germing, U., Haase, D., Hellstrom-Lindberg, E., Johansson, U., Kordasti, S., Loken, M.R., Malcovati, L., Marvelde, J.G. Te, Matarraz, S., Milne, T., Moshaver, B., Mufti, G.J., Nikolova, V., Ogata, K., Oelschlaegel, U., Orfao, A., Ossenkoppele, G.J., Porwit, A., Platzbecker, U., Preijers, F.W.M.B., Psarra, K., Richards, S.J., Subira, D., Seymour, J.F., Tindell, V., Vallespi, T., Valent, P., Velden, V.H. van der, Wells, D.A., Witte, T.J.M. de, Zettl, F., Bene, M.C., and Westers, T.M.
- Abstract
Item does not contain fulltext, An international working group within the European LeukemiaNet gathered, aiming to determine the role of flow cytometry (FC) in myelodysplastic syndromes (MDS). It was agreed that FC has a substantial application in disease characterization, diagnosis and prognosis. FC may also be useful in predicting treatment responses and monitoring novel and standard therapeutic regimens. In this article the rationale is discussed that flow cytometry should be integrated as a part of diagnostic and prognostic scoring systems in MDS.
- Published
- 2013
32. Standardization of flow cytometry in myelodysplastic syndromes: a report from an international consortium and the European LeukemiaNet Working Group.
- Author
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Westers, T.M., Ireland, R., Kern, W., Alhan, C., Balleisen, J.S., Bettelheim, P., Burbury, K., Cullen, M., Cutler, J.A., Porta, M.G. Della, Drager, A.M., Feuillard, J., Font, P., Germing, U., Haase, D., Johansson, U., Kordasti, S., Loken, M.R., Malcovati, L., Marvelde, J.G. Te, Matarraz, S., Milne, T., Moshaver, B., Mufti, G.J., Ogata, K., Orfao, A., Porwit, A., Psarra, K., Richards, S.J., Subira, D., Tindell, V., Vallespi, T., Valent, P., Velden, V.H. van der, Witte, T.J.M. de, Wells, D.A., Zettl, F., Bene, M.C., Loosdrecht, A.A. van de, Westers, T.M., Ireland, R., Kern, W., Alhan, C., Balleisen, J.S., Bettelheim, P., Burbury, K., Cullen, M., Cutler, J.A., Porta, M.G. Della, Drager, A.M., Feuillard, J., Font, P., Germing, U., Haase, D., Johansson, U., Kordasti, S., Loken, M.R., Malcovati, L., Marvelde, J.G. Te, Matarraz, S., Milne, T., Moshaver, B., Mufti, G.J., Ogata, K., Orfao, A., Porwit, A., Psarra, K., Richards, S.J., Subira, D., Tindell, V., Vallespi, T., Valent, P., Velden, V.H. van der, Witte, T.J.M. de, Wells, D.A., Zettl, F., Bene, M.C., and Loosdrecht, A.A. van de
- Abstract
1 juli 2012, Item does not contain fulltext, Flow cytometry (FC) is increasingly recognized as an important tool in the diagnosis and prognosis of myelodysplastic syndromes (MDS). However, validation of current assays and agreement upon the techniques are prerequisites for its widespread acceptance and application in clinical practice. Therefore, a working group was initiated (Amsterdam, 2008) to discuss and propose standards for FC in MDS. In 2009 and 2010, representatives from 23, mainly European, institutes participated in the second and third European LeukemiaNet (ELN) MDS workshops. In the present report, minimal requirements to analyze dysplasia are refined. The proposed core markers should enable a categorization of FC results in cytopenic patients as 'normal', 'suggestive of', or 'diagnostic of' MDS. An FC report should include a description of validated FC abnormalities such as aberrant marker expression on myeloid progenitors and, furthermore, dysgranulopoiesis and/or dysmonocytopoiesis, if at least two abnormalities are evidenced. The working group is dedicated to initiate further studies to establish robust diagnostic and prognostic FC panels in MDS. An ultimate goal is to refine and improve diagnosis and prognostic scoring systems. Finally, the working group stresses that FC should be part of an integrated diagnosis rather than a separate technique.
- Published
- 2012
33. Standardization of flow cytometry in myelodysplastic syndromes: report from the first European LeukemiaNet working conference on flow cytometry in myelodysplastic syndromes.
- Author
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Loosdrecht, A.A. van de, Alhan, C., Bene, M.C., Porta, M.G. Della, Drager, A.M., Feuillard, J., Font, P., Germing, U., Haase, D., Homburg, C.H., Ireland, R., Jansen, J.H., Kern, W., Malcovati, L., Marvelde, J.G. Te, Mufti, G.J., Ogata, K., Orfao, A., Ossenkoppele, G.J., Porwit, A., Preijers, F.W.M.B., Richards, S.J., Schuurhuis, G.J., Subira, D., Valent, P., Velden, V.H. van der, Vyas, P., Westra, A.H., Witte, T.J.M. de, Wells, D.A., Loken, M.R., Westers, T.M., Loosdrecht, A.A. van de, Alhan, C., Bene, M.C., Porta, M.G. Della, Drager, A.M., Feuillard, J., Font, P., Germing, U., Haase, D., Homburg, C.H., Ireland, R., Jansen, J.H., Kern, W., Malcovati, L., Marvelde, J.G. Te, Mufti, G.J., Ogata, K., Orfao, A., Ossenkoppele, G.J., Porwit, A., Preijers, F.W.M.B., Richards, S.J., Schuurhuis, G.J., Subira, D., Valent, P., Velden, V.H. van der, Vyas, P., Westra, A.H., Witte, T.J.M. de, Wells, D.A., Loken, M.R., and Westers, T.M.
- Abstract
Contains fulltext : 81483.pdf (publisher's version ) (Open Access), The myelodysplastic syndromes are a group of clonal hematopoietic stem cell diseases characterized by cytopenia(s), dysplasia in one or more cell lineages and increased risk of evolution to acute myeloid leukemia (AML). Recent advances in immunophenotyping of hematopoietic progenitor and maturing cells in dysplastic bone marrow point to a useful role for multiparameter flow cytometry (FCM) in the diagnosis and prognostication of myelodysplastic syndromes. In March 2008, representatives from 18 European institutes participated in a European LeukemiaNet (ELN) workshop held in Amsterdam as a first step towards standardization of FCM in myelodysplastic syndromes. Consensus was reached regarding standard methods for cell sampling, handling and processing. The group also defined minimal combinations of antibodies to analyze aberrant immunophenotypes and thus dysplasia. Examples are altered numbers of CD34(+) precursors, aberrant expression of markers on myeloblasts, maturing myeloid cells, monocytes or erythroid precursors and the expression of lineage infidelity markers. When applied in practice, aberrant FCM patterns correlate well with morphology, the subclassification of myelodysplastic syndromes, and prognostic scoring systems. However, the group also concluded that despite strong evidence for an impact of FCM in myelodysplastic syndromes, further (prospective) validation of markers and immunophenotypic patterns are required against control patient groups as well as further standardization in multi-center studies. Standardization of FCM in myelodysplastic syndromes may thus contribute to improved diagnosis and prognostication of myelodysplastic syndromes in the future.
- Published
- 2009
34. Standardization of flow cytometry in myelodysplastic syndromes: Report from the first European LeukemiaNet working conference on flow cytometry in myelodysplastic syndromes
- Author
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Loosdrecht, A.A. (Arjan) van de, Alhan, C. (Canan), Béné, M.C., Della Porta, M.G. (Matteo), Dräger, A.M. (Angelika), Feuillard, J. (Jean), Font, P. (Patricia), Germing, U. (Ulrich), Haase, D. (Detlef), Homburg, C.H. (Christa), Ireland, R. (Robin), Jansen, J.H. (Joop), Kern, W. (Wolfgang), Malcovati, L. (Luca), Marvelde, J.G. (Jeroen) te, Mufti, G.J. (Ghulam), Ogata, K. (Kiyoyuki), Orfao, A. (Alberto), Ossenkoppele, G.J. (Gert), Porwit, A. (Anna), Preijers, F.W.M.B. (Frank), Richards, S.J. (Stephen), Schuurhuis, G.J. (Gerrit Jan), Subirá, D. (Dolores), Valent, P. (Peter), Velden, V.H.J. (Vincent) van der, Vyas, P. (Paresh), Westra, A.H. (August), Witte, T. de, Wells, D.A. (Denise), Loken, M.R. (Michael), Westers, T.M. (Theresia), Loosdrecht, A.A. (Arjan) van de, Alhan, C. (Canan), Béné, M.C., Della Porta, M.G. (Matteo), Dräger, A.M. (Angelika), Feuillard, J. (Jean), Font, P. (Patricia), Germing, U. (Ulrich), Haase, D. (Detlef), Homburg, C.H. (Christa), Ireland, R. (Robin), Jansen, J.H. (Joop), Kern, W. (Wolfgang), Malcovati, L. (Luca), Marvelde, J.G. (Jeroen) te, Mufti, G.J. (Ghulam), Ogata, K. (Kiyoyuki), Orfao, A. (Alberto), Ossenkoppele, G.J. (Gert), Porwit, A. (Anna), Preijers, F.W.M.B. (Frank), Richards, S.J. (Stephen), Schuurhuis, G.J. (Gerrit Jan), Subirá, D. (Dolores), Valent, P. (Peter), Velden, V.H.J. (Vincent) van der, Vyas, P. (Paresh), Westra, A.H. (August), Witte, T. de, Wells, D.A. (Denise), Loken, M.R. (Michael), and Westers, T.M. (Theresia)
- Abstract
The myelodysplastic syndromes are a group of clonal hematopoietic stem cell diseases characterized by cytopenia(s), dysplasia in one or more cell lineages and increased risk of evolution to acute myeloid leukemia (AML). Recent advances in immunophenotyping of hematopoietic progenitor and maturing cells in dysplastic bone marrow point to a useful role for multiparameter flow cytometry (FCM) in the diagnosis and prognostication of myelodysplastic syndromes. In March 2008, representatives from 18 European institutes participated in a European LeukemiaNet (ELN) workshop held in Amsterdam as a first step towards standardization of FCM in myelodysplastic syndromes. Con
- Published
- 2009
- Full Text
- View/download PDF
35. Standardization of flow cytometry in myelodysplastic syndromes: report from the first European LeukemiaNet working conference on flow cytometry in myelodysplastic syndromes
- Author
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van de Loosdrecht, AA, Alhan, C, Bene, MC, Della Porta, MG, Drager, AM, Feuillard, J, Font, P, Germing, U, Haase, D, Homburg, CH, Ireland, R, Jansen, JH (Joop), Kern, W, Malcovati, L, te Marvelde, Jeroen, Mufti, GJ, Ogata, K, Orfao, A, Ossenkoppele, GJ, Porwit, A, Preijers, FW, Richards, SJ, Schuurhuis, GJ, Subira, D, Valent, P, van der Velden, Vincent, Vyas, P, Westra, AH, de Witte, TM, Wells, DA, Loken, MR, Westers, TM, van de Loosdrecht, AA, Alhan, C, Bene, MC, Della Porta, MG, Drager, AM, Feuillard, J, Font, P, Germing, U, Haase, D, Homburg, CH, Ireland, R, Jansen, JH (Joop), Kern, W, Malcovati, L, te Marvelde, Jeroen, Mufti, GJ, Ogata, K, Orfao, A, Ossenkoppele, GJ, Porwit, A, Preijers, FW, Richards, SJ, Schuurhuis, GJ, Subira, D, Valent, P, van der Velden, Vincent, Vyas, P, Westra, AH, de Witte, TM, Wells, DA, Loken, MR, and Westers, TM
- Abstract
The myelodysplastic syndromes are a group of clonal hematopoietic stem cell diseases characterized by cytopenia(s), dysplasia in one or more cell lineages and increased risk of evolution to acute myeloid leukemia (AML). Recent advances in immunophenotyping of hematopoietic progenitor and maturing cells in dysplastic bone marrow point to a useful role for multiparameter Row cytometry (FCM) in the diagnosis and prognostication of myelodysplastic syndromes. In March 2008, representatives from 18 European institutes participated in a European LeukemiaNet (ELN) workshop held in Amsterdam as a first step towards standardization of FCM in myelodysplastic syndromes. Consensus was reached regarding standard methods for cell sampling, handling and processing. The group also defined minimal combinations of antibodies to analyze aberrant immunophenotypes and thus dysplasia. Examples are altered numbers of CD34(+) precursors, aberrant expression of markers on myeloblasts, maturing myeloid cells, monocytes or erythroid precursors and the expression of lineage infidelity markers. When applied in practice, aberrant FCM patterns correlate well with morphology, the subclassification of myelodysplastic syndromes, and prognostic scoring systems. However, the group also concluded that despite strong evidence for an impact of FCM in myelodysplastic syndromes, further (prospective) validation of markers and immunophenotypic patterns are required against control patient groups as well as further standardization in multi-center studies. Standardization of FCM in myelodysplastic syndromes may thus contribute to improved diagnosis and prognostication of myelodysplastic syndromes in the future.
- Published
- 2009
36. RelA and RelB cross-talk and function in Epstein–Barr virus transformed B cells
- Author
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Chanut, A, primary, Duguet, F, additional, Marfak, A, additional, David, A, additional, Petit, B, additional, Parrens, M, additional, Durand-Panteix, S, additional, Boulin-Deveza, M, additional, Gachard, N, additional, Youlyouz-Marfak, I, additional, Bordessoule, D, additional, Feuillard, J, additional, and Faumont, N, additional
- Published
- 2013
- Full Text
- View/download PDF
37. IGHV gene features and MYD88 L265P mutation separate the three marginal zone lymphoma entities and Waldenström macroglobulinemia/lymphoplasmacytic lymphomas
- Author
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Gachard, N, primary, Parrens, M, additional, Soubeyran, I, additional, Petit, B, additional, Marfak, A, additional, Rizzo, D, additional, Devesa, M, additional, Delage-Corre, M, additional, Coste, V, additional, Laforêt, M P, additional, de Mascarel, A, additional, Merlio, J P, additional, Bouabdhalla, K, additional, Milpied, N, additional, Soubeyran, P, additional, Schmitt, A, additional, Bordessoule, D, additional, Cogné, M, additional, and Feuillard, J, additional
- Published
- 2012
- Full Text
- View/download PDF
38. 137 Standardization of flow cytometry in myelodysplastic syndromes: A report from an international consortium and the European LeukemiaNet Working Group
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Westers, T.M., primary, Ireland, R., additional, Kern, W., additional, Alhan, C., additional, Balleisen, J.S., additional, Béné, M.C., additional, Bettelheim, P., additional, Burbury, K., additional, Cullen, M., additional, Cutler, J.A., additional, Porta, M.G. Della, additional, Drager, A.M., additional, Feuillard, J., additional, Font, P., additional, Germing, U., additional, Haase, D., additional, Johansson, U., additional, Kordasti, S., additional, Loken, M.R., additional, Malcovati, L., additional, te Marvelde, J.G., additional, Matarraz, S., additional, Milne, T., additional, Moshaver, B., additional, Mufti, G.J., additional, Ogata, K., additional, Orfao, A., additional, Porwit, A., additional, Psarra, K., additional, Richards, S.J., additional, Subirá, D., additional, Tindell, V., additional, Vallespi, T., additional, Valent, P., additional, van der Velden, V.H., additional, de Witte, T.M., additional, Wells, D.A., additional, Zettl, F., additional, and van de Loosdrecht, A.A., additional
- Published
- 2011
- Full Text
- View/download PDF
39. 115 ImageStream* quantitative analysis of cytomorphological and immunophenotypic erythroid cell lineage dyplasia in myelodysplastic syndromes
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Ouk-Martin, C., primary, Guérin, E., additional, Gourin, M.-P., additional, Jayat-Vignoles, C., additional, Faucher, J.-L, additional, Le Guyader, A., additional, Trimoreau, F., additional, Bordessoule, D., additional, and Feuillard, J., additional
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- 2011
- Full Text
- View/download PDF
40. 148 Myelodysplastic syndrome in very elderly patients: practice in the real life. Preliminary results on a monocentric cohort
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Gourin, M.-P., primary, Gachard, N., additional, Trimoreau, F., additional, Abraham, J., additional, Moreau, S., additional, Mallissein, E., additional, Touati, M., additional, Feuillard, J., additional, and Bordessoule, D., additional
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- 2011
- Full Text
- View/download PDF
41. Étapes préanalytiques pour la cytométrie en flux appliquée aux hémopathies
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Trimoreau, F., primary, Guérin, E., additional, Gachard, N., additional, Leymarie, V., additional, Faucher, J.-L., additional, Feuillard, J., additional, and Béné, M.-C., additional
- Published
- 2011
- Full Text
- View/download PDF
42. Étapes préanalytiques pour la cytologie médullaire, ganglionnaire et des liquides biologiques
- Author
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Trimoreau, F., primary, Gachard, N., additional, Vrain, A., additional, Leymarie, V., additional, Perroud, P., additional, and Feuillard, J., additional
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- 2011
- Full Text
- View/download PDF
43. Étapes préanalytiques pour la numération et cytologie sanguine
- Author
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Trimoreau, F., primary, Gachard, N., additional, Leymarie, V., additional, Frébet, E., additional, Perroud, P., additional, and Feuillard, J., additional
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- 2011
- Full Text
- View/download PDF
44. R145: Facteurs transcriptionnels associés au lymphome de Burkitt
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Feuillard, J., primary and Carrion, C., additional
- Published
- 2010
- Full Text
- View/download PDF
45. R16: Régulation de l’expression de l’immuno-inhibiteur B7-H1 dans les cellules B infectées par le virus d’Epstein-Barr
- Author
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Durand-Panteix, S., primary, Rouraud, P., additional, David, A., additional, Faumont, N., additional, Feuillard, J., additional, and Jayat-Vignoles, C., additional
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- 2010
- Full Text
- View/download PDF
46. R12: Coopération entre c-Myc et le programme de latence III du virus d’Epstein-Barr dans la prolifération : rôle de NF-kappaB ?
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David, A., primary, Feuillard, J., additional, and Faumont, N., additional
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- 2010
- Full Text
- View/download PDF
47. R17: Fonction et poids différentiel des complexes NF-kappaB contenant RelA ou RelB dans les lymphocytes B transformés par le virus d’Epstein-Barr et dans les lymphomes B diffus à grandes cellules de type activé
- Author
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Chanut, A., primary, Durand-Panteix, S., additional, Weinbreck, N., additional, Youlyouz-Marfak, I., additional, Bordessoule, D., additional, Feuillard, J., additional, and Faumont, N., additional
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- 2010
- Full Text
- View/download PDF
48. Epidemiological review of lymphoma diagnosis in a French rural area between 2003 and 2008.
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Touati, M., primary, Gourin, M., additional, Abraham, J., additional, Weinbreck, N., additional, Gachard, N., additional, Olivrie-Gamaury, A., additional, Feuillard, J., additional, Jaccard, A., additional, and Bordessoule, D., additional
- Published
- 2010
- Full Text
- View/download PDF
49. Increased of overall survival (OS) and malignancies (K) during tyrosine kinase inhibitors (TKI) in a real life cohort of patients (pts) with a chronic myeloid leukemia (CML).
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Gourin, M., primary, Turlure, P., additional, Gachard, N., additional, Girault, S., additional, Touati, M., additional, Abraham, J., additional, Philippon, C., additional, Feuillard, J., additional, and Bordessoule, D., additional
- Published
- 2010
- Full Text
- View/download PDF
50. Immunophenotypic clustering of myelodsplastic syndromes
- Author
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UCL - MD/BICL - Département de biochimie et de biologie cellulaire, Maynadie, M, Picard, F, Husson, B., Chatelain, Bernard, Cornet, Yvan, Le Roux, G, Campos, L, Dromelet, A., Lepelley, P, Jouault, H, Imbert, M., Rosenwadj, M, Verge, V, Bissieres, P, Raphael, M., Bene, MC, Feuillard, J, UCL - MD/BICL - Département de biochimie et de biologie cellulaire, Maynadie, M, Picard, F, Husson, B., Chatelain, Bernard, Cornet, Yvan, Le Roux, G, Campos, L, Dromelet, A., Lepelley, P, Jouault, H, Imbert, M., Rosenwadj, M, Verge, V, Bissieres, P, Raphael, M., Bene, MC, and Feuillard, J
- Abstract
Myelodysplastic syndromes (MDSs) are heterogeneous diseases of bone marrow (BM) cell precursors for which immunophenotypic characterization is still considered irrelevant despite the accuracy and sensitivity of flow cytometry techniques. The aim of this study was to determine whether immunophenotypic abnormalities could be defined In MDSs and could correlate with the French-American-British classification and cytogenetics. Analysis was performed on 275 BM samples (207 MDS patients, 68 controls) and 25 control blood samples. immunophenotyping was based on a primary gating of blast cells, monocytes, and granulocytes according to CD45 antigen expression and side scatter light diffraction. Immunophenotypic hierarchical clustering was performed to analyze the results, The data obtained show that (1) immunophenotypic clustering partly discriminates patients with refractory anemia with excess blasts/refractory anemia with excess blasts in transformation (RAEB/RAEB-T), chronic myelomonocytic leukemia (CMML), and refractory anemia/refractory anemia with ring sideroblasts (RA/RARS) for CD45(lo) blast cells and patients with RA/CMML, RARS, and RAEB/RAEB-T for CD45(hi)/side scafter(hi) (SShi) granulocytes; (2) the most discriminating markers were CD16, CD34, CD36, CD38, CD71, and HLA-DR for blast cells and CD11b, CD13, CD33, CD36, CD38, CD71, and HLA-DR for CD45(hi)/SShi granulocytes; (3) clusters related to CD34 expression were associated with high levels of blast cells on BM smear; (4) clusters related to high levels of CD36 expression on CD45(lo) blast cells and CID45(hi)/SShi granulocytes were associated with a poor International Prognosis Scoring System score; and (5) high levels of CD71 expression on CD45(hi)/SShi granulocytes were associated with the RARS category. These results show a close relationship between Immunophenotypic abnormalities and BM dysplasia and suggest that flow cytometry could be a future tool for the characterization of MDSs. (C) 2002 by The American
- Published
- 2002
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