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2 results on '"Fetal Death/immunology"'

1. Antiphospholipid antibodies in eclamptic women

Author

Babür Kaleli, Filiz Akşit, Ilknur Kaleli, Erdal Aktan, and Cem Turan

Subjects
Male, phospholipid antibody, eclampsia, Pregnancy, Medicine, Eclampsia, Perinatal mortality, clinical article, Fetal Growth Retardation, Growth retardation, Fetal death, biology, Obstetrics, antibody blood level, article, Obstetrics and Gynecology, intrauterine growth retardation, female, priority journal, risk factor, In utero, embryonic structures, Antibodies, Antiphospholipid, Female, Antibody, psychological phenomena and processes, Adult, medicine.medical_specialty, education, prevalence, cardiolipin antibody, antiphospholipid antibodies, perinatal mortality, statistical analysis, Antibodies, Antiphospholipid/*blood, Eclampsia/*immunology, Fetal Death/immunology, Fetal Growth Retardation/immunology, Humans, mental disorders, controlled study, human, Risk factor, Fetal Death, Fetus, high risk pregnancy, business.industry, Antiphospholipid antibodies, medicine.disease, fetus death, human tissue, Reproductive Medicine, biology.protein, business
Abstract

Our purpose was to determine the prevalence of antiphospholipid antibodies (APA) in eclamptic women as well as the rates of intrauterine growth retardation (IUGR) and fetal death in APA-positive and -negative eclamptic women. Thirty-six eclamptic and 30 healthy pregnant women were enrolled in this study. APA in those groups were determined. The prevalences of IUGR and fetal death were determined in APA-positive and -negative eclamptic women. In the eclamptic group, APA were positive in 9 out of 36 patients (25%), where as only 2 out of 30 controls (6.7%) were positive (p < 0.05). Fetal death was encountered in 4 out of 9 (44.4%) APA-positive eclamptic women; this was a significantly larger proportion than that for APA-negative eclamptic women (1/27; p < 0.01). The rates of IUGR in APA-positive and -negative eclamptic women were not significantly different (p > 0.05). Similar conclusions about our results could also be made, when weakly positive anticardiolipin antibodies were regarded as negative in our study group and controls. Our study suggests that positive levels of APA in eclamptic women increase the risk for intrauterine fetal death.

Published
1998

2. Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death

Author

Hurtado, V. (Verónica)

Subjects
Antiphospholipid syndrome/immunology, Autoantibodies/blood, Endothelins/immunology, Fetal death/immunology, Pregnancy complications/immunology
Abstract

The antiphospholipid syndrome (APS) is associated with thrombosis and fetal death but the pathologic mechanisms are poorly understood. Since endothelial protein C receptor (EPCR) plays a role in the anticoagulant system and in placental development, we hypothesized that anti-EPCR autoantibodies may be involved in clinical manifestations of APS and in fetal loss. The levels of immunoglobulin M (IgM) and IgG anti-EPCR autoantibodies were analyzed by enzyme-linked immunosorbent assay (ELISA) in 43 patients with APS and 43 controls. Anti-EPCR levels were higher in APS patients than in controls. Interestingly, one of the IgM anti-EPCR autoantibodies inhibited the generation of activated protein C on endothelium. Since markedly high anti-EPCR levels were found in women with fetal death, 87 patients with a first episode of unexplained fetal death were subsequently analyzed and their anti-EPCR levels were compared with 87 matched controls. We found that anti-EPCR autoantibodies constitute an independent risk factor for a first fetal death episode: the adjusted odds ratios (ORs) for anti-EPCR autoantibodies above the 95th percentile were 23.0 (95% confidence interval [CI], 2.0-266.3) for IgM and 6.8 (95% CI, 1.2-38.4) for IgG. Anti-EPCR autoantibodies can be detected in APS patients and are independent risk factors for fetal death.

Published
2004

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