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4. Flapping states of an el astically anchored wing in a uniform flow

Author

Orchini, A., Mazzino, A., Guerrero, J., Festa, R., and Boragno, C.

Subjects
Physics - Fluid Dynamics
Abstract

Linear stability analysis of an elastically anchored wing in a uniform flow is investigated both analytically and numerically. The analytical formulation explicitly takes into account the effect of the wake on the wing by means of Theodorsen's theory. Three different parameters non-trivially rule the observed dynamics: mass density ratio between wing and fluid, spring elastic constant and distance between the wing center of mass and the spring anchor point on the wing. We found relationships between these parameters which rule the transition between stable equilibrium and fluttering. The shape of the resulting marginal curve has been successfully verified by high Reynolds number direct numerical simulations. Our findings are of interest in applications related to energy harvesting by fluid-structure interaction, a problem which has recently attracted a great deal of attention. The main aim in that context is to identify the optimal physical/geometrical system configuration leading to large sustained motion, which is the source of energy we aim to extract., Comment: 10 pages, 11 figures, submitted to J. Fluid. Mech

Published
2012

5. Large-Eddy Simulation closures of passive scalar turbulence: a systematic approach

Author

Afonso, M. Martins, Celani, A., Festa, R., and Mazzino, A.

Subjects
Nonlinear Sciences - Chaotic Dynamics, Physics - Atmospheric and Oceanic Physics, Physics - Fluid Dynamics
Abstract

The issue of the parameterization of small scale (``subgrid'') turbulence is addressed in the context of passive scalar transport. We focus on the Kraichnan advection model which lends itself to the analytical investigation of the closure problem. We derive systematically the dynamical equations which rule the evolution of the coarse-grained scalar field. At the lowest-order approximation in $l/r$, $l$ being the characteristic scale of the filter defining the coarse-grained scalar field and $r$ the inertial range separation, we recover the classical eddy-diffusivity parameterization of small scales. At the next-leading order a dynamical closure is obtained. The latter outperforms the classical model and is therefore a natural candidate for subgrid modelling of scalar transport in generic turbulent flows., Comment: 10 LaTex pages, 1 PS figure. Changes: comments added below previous (3.10); Previous (3.16) has been corrected; Minor changes in the conclusions

Published
2003
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6. Lorenz deterministic diffusion

Author

Festa, R., Mazzino, A., and Vincenzi, D.

Subjects
Nonlinear Sciences - Chaotic Dynamics
Abstract

The Lorenz 1963 dynamical system is known to reduce in the steady state to a one-dimensional motion of a classical particle subjected to viscous damping in a past history-dependent potential field. If the potential field is substituted by a periodic function of the position, the resulting system shows a rich dynamics where (standard) diffusive behaviours, ballistc motions and trapping take place by varying the model control parameters. This system permits to highlight the intimate relation between chaos and long-time deterministic diffusion., Comment: 7 pages, 12 figures

Published
2002
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7. Lorenz-like systems and classical dynamical equations with memory forcing: a new point of view for singling out the origin of chaos

Author

Festa, R., Mazzino, A., and Vincenzi, D.

Subjects
Nonlinear Sciences - Chaotic Dynamics
Abstract

A novel view for the emergence of chaos in Lorenz-like systems is presented. For such purpose, the Lorenz problem is reformulated in a classical mechanical form and it turns out to be equivalent to the problem of a damped and forced one dimensional motion of a particle in a two-well potential, with a forcing term depending on the ``memory'' of the particle past motion. The dynamics of the original Lorenz system in the new particle phase space can then be rewritten in terms of an one-dimensional first-exit-time problem. The emergence of chaos turns out to be due to the discontinuous solutions of the transcendental equation ruling the time for the particle to cross the intermediate potential wall. The whole problem is tackled analytically deriving a piecewise linearized Lorenz-like system which preserves all the essential properties of the original model., Comment: 48 pages, 25 figures

Published
2002
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8. At the very origin of chaos in three-dimensional dynamical systems

Author

Festa, R., Mazzino, A., and Vincenzi, D.

Subjects
Nonlinear Sciences - Chaotic Dynamics
Abstract

The mechanism responsible for the emergence of chaotic behavior has been identified analytically within a class of three-dimensional dynamical systems which generalize the well-known E.N. Lorenz 1963 system. The dynamics in the phase space has been reformulated in terms of a first-exit-time problem. Chaos emerges due to discontinuous solutions of a transcendental problem ruling the time for a particle to cross a potential wall. Numerical results point toward the genericity of the new found mechanism., Comment: 4 pages, 4 figures

Published
2000

9. Discretizing ups-Andromedae planetary system

Author

Agnese, A. G. and Festa, R.

Subjects
Astrophysics
Abstract

Starting from a previously stated hypothesis concerning the discretization of the orbits for periodic celestial motions, the mass of ups-Andromedae and the periods of its b- and d- companions are estimated using the accurately known period of the massive c-companion. Moreover, the periods and the orbital major semiaxes of other hypotetically existing and not yet discovered smaller planets of ups-Andromedae are guessed., Comment: 6 pages

Published
1999

10. Different transport regimes in a spatially-extended recirculating background

Author

Castiglione, P., Festa, R., and Mazzino, A.

Subjects
Nonlinear Sciences - Chaotic Dynamics
Abstract

Passive scalar transport in a spatially-extended background of roll convection is considered in the time-periodic regime. The latter arises due to the even oscillatory instability of the cell lateral boundary, here accounted for by sinusoidal oscillations of frequency $\omega$. By varying the latter parameter, the strength of anticorrelated regions of the velocity field can be controled and the conditions under which either an enhancement or a reduction of transport takes place can be created. Such two ubiquitous regimes are triggered by a small-scale(random) velocity field superimposed to the recirculating background. The crucial point is played by the dependence of Lagrangian trajectories on the statistical properties of the small-scale velocity field, e.g. its correlation time or its energy., Comment: 9 pages Latex; 5 figures

Published
1999
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11. Discretization on the cosmic scale inspired from the Old Quantum Mechanics

Author

Agnese, A. G. and Festa, R.

Subjects
Astrophysics
Abstract

The Old Quantum Mechanics actions discretization rules for periodic motions on the atomic scale (Bohr-Sommerfeld) have been suitably modified in order to account the gravitational field instead of the electrostatic one. The new rules are used to calculate a few mechanical quantities pertinent to the periodic motions of celestial bodies. Several values have been obtained which result in reasonable agreement with the corresponding experimental data. A gravitational dimensionless structure constant has been determined, using the data relative to the solar sistem, which allows to quantitatively account for phenomena on a much wider scale. In particular, some information is acquired about the recently discovered extrasolar planetary systems and about the general empirical law which connects the spin of a celestial body with the square of its mass., Comment: 17 pages, LaTex, 2 Postscript figures

Published
1998

13. Effect of beetroot (Beta vul-garis) extract on black angus burgers shelf life

Author

Marrone R., Smaldone G., Ambrosio R. L., Festa R., Ceruso M., Chianese A., Anastasio A., Marrone, R., Smaldone, G., Ambrosio, R. L., Festa, R., Ceruso, M., Chianese, A., and Anastasio, A.

Subjects
Vacuum, Antimicrobial, Plant, Lipid oxidation, Colour
Abstract

Beef burgers are meat preparations with easy perishability. To ensure a longer shelf-life, the Regulation EU 1129/11 allows the use of some additives. However, health-conscious consumers prefer products which do not contain synthetic substances. Aim of the present study was to evaluate the effect of Red Beetroot (Beta vulgaris) integration on Black Angus made burgers shelf life. Red beet was prepared as powder and added to meat mixture as the same or in water solution. The study was split into 2 trials to assess the extract activity also in burgers vacuum-packaged stored. Burgers were analysed (up to 9 days at 4°C) in terms of sensory properties, microbiological profile, pH, aw and lipid oxidation (TBARS). At the end of storage, treated samples showed the highest values of redness and the lowest content of malondialdehyde, probably due to antioxidant properties of red beet towards myoglobin and lipid oxidation processes. Moreover, results highlighted that Red Beetroot activities were dose-dependent and intensified if dissolved in water. The aw values did not appear to be conditioned by extract integrations, unlike the pH that was lower in treated samples than control ones. Microbiological analyses identified beet-root as a potential antimicrobial substance, especially in high concentration. In conclusion, Beta vulgaris extract could be pro-posed as natural compound exploitable in beef burgers to preserve qualities and extend their shelf-life.

Published
2021

14. Recensione del volume di Beniamino Di Martino, Libertà e coronavirus, Monolateral, Dallas (Texas, USA) 2020

Author

Festa, R. and Festa, R.

Subjects
filosofia della politica, esperti, pandemia, COVID
Abstract

Consiglio calorosamente di leggere il libro. Sono di 436 pagine, ma lo leggi d’un fiato, o forse in quattro o cinque fiati. Se anche togliessimo tutte le parti sul coronavirus e lasciassimo le altre potrebbe essere un’introduzione non solo al libertarismo, ma anche alle relazioni fra la dottrina cattolica e le posizioni liberali e libertarie. Questo spiega il fatto che la prima parte del libro, intitolata Il virus del politicamente corretto (considerazioni sociali) è un’analisi di centosessanta pagine che forma quasi un volumetto che sta in piedi da solo. Si tratta, infatti, di un’analisi di tutti i miti statalisti che preesistevano al virus e che sono stati riattivati dal virus. La seconda parte (Si suicidavano per paura di morire) comprende considerazioni economiche. La terza (La Cina e il suo virus ideologico) contiene considerazioni geopolitiche, con alcune profezie sul crollo del comunismo cinese. Infine il breve capitolo finale — Chiudete le porte a Cristo — è dedicato a considerazioni di tipo teologico. Quest’ultima parte – che volevo assolutamente ignorare, se non per altro per la presenza di Aldo Maria Valli, che è ben più titolato di me a parlarne –, ha fatto suonare dei campanellini autobiografici nella mia mente, perché l’autore parla dell’atteggiamento della pastorale della Chiesa rispetto ai temi della morte, della malattia e del diverso atteggiamento degli atei e dei credenti nei confronti della morte, il cui pensiero viene riattivato dalla pandemia.

Published
2021

15. Industrial Applications of Surfactants, and Surfactants in Emerging Technologies

Author

Hou, M. J., Hui, Sai H., Ling, F. F., Hancock, T. D., Olson, C. R., Friberg, S. E., Chiu, M., Ludema, K., Reboa, Paul F., Terech, P., Krishnan, R., Bassemir, R. W., Mitsuishi, M., Yagi, T., Ishiwatari, T., Hamada, K., Takaoka, T., Palepu, R., Hall, D. G., Wyn-Jones, E., Pingret, F. J., Sohm, R. H., Tadros, Th. F., Schick, M. J., Christ, Geoffrey, Jho, Chang, Biresaw, G., Reich, R. A., Leung, R. Y., Bohaychick, J., Festa, R. P., Zadnik, D. A., Huang, S.-D., Huang, J.-Y., Cheng, M.-H., Sheu, G.-L., Rawat, N. S., Roy, Sisir Kumar, Nguyen, H., Rao, M., Phillips, J. B., John, V. T., Malbrel, C. A., Somasundaran, P., Krei, G. A., Hustedt, H., Srivastava, R. C., Mukhopadhyay, Mausumi, Guha Majumdar, Anupa, Jana, Asok K., Bhandarkar, Suhas, Bose, Arijit, Jie, Hu, Wen-Bin, Qi, Bin-Yin, Pu, Wolff, Thomas, Klaußner, Bernhard, von Bünau, Günther, Kumar, P., Ayyub, P., Maitra, A., Shah, D. O., Nechifor, Gh., Nechifor, Mariane, Popescu, Georgeta, Albu, B., Mahakalkar, A. S., Munshi, K. N., Sinha, D. R., Guha, D., Rutherford, C. E., Salter, L. F., Park, Sang Joon, Neuman, Ronald D., Qutubuddin, Syed, Kayima, P., Bhowmik, Benoy B., Sen-Varma, Chirasree, Chatterjee, Ira, Bhattacharya, Sharmila, Perez, Angel Valea, Gonzalez Arce, M. L., Amire, O. A., Van der Auweraer, M., De Schryver, F. C., Mittal, K. L., editor, and Shah, D. O., editor

Published
1991
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16. Serum levels of polychlorinated biphenyls and risk of non-Hodgkin lymphoma: A hospital-based case-control study

Author

Magoni, M., Donato, F., Apostoli, P., Rossi, G., Comba, P., Fazzo, L., Speziani, F., Leonardi, L., Orizio, G., Scarcella, C., Anastasia, A., Tucci, A., Terraroli, C., Coniglio, A., Zarattini, G., Manca, G., Fostinelli, J., Festa, R., Conti, M., and Micheletti, S.

Subjects
Male, Lymphoma, Health, Toxicology and Mutagenesis, 0208 environmental biotechnology, Physiology, 02 engineering and technology, 010501 environmental sciences, 01 natural sciences, Risk Factors, immune system diseases, hemic and lymphatic diseases, 80 and over, Medicine, Aged, 80 and over, Air Pollutants, education.field_of_study, Non-hodgkin lymphoma, Lymphoma, Non-Hodgkin, Incidence, General Medicine, Hospital based, Middle Aged, Control subjects, Polychlorinated Biphenyls, Pollution, Occupational, Hospitals, Italy, Quartile, Female, Adult, Environmental Engineering, Population, Non-Hodgkin, Air Pollutants, Occupational, Young Adult, Occupational Exposure, Humans, Environmental Chemistry, Environmental risk factors, education, Aged, 0105 earth and related environmental sciences, business.industry, Public Health, Environmental and Occupational Health, Case-control study, Cancer, General Chemistry, medicine.disease, 020801 environmental engineering, Polychlorinated biphenyls, Case-Control Studies, Hodgkin lymphoma, business
Abstract

Polychlorinated biphenyls (PCB) have been classified by the International Agency for Research on Cancer (IARC) in Group 1 as carcinogenic to human, based on sufficient evidence in humans of an increased risk of cutaneous malignant melanoma and limited evidence for non-Hodgkin lymphoma (NHL). However present findings on the association of PCB exposure and NHL are still controversial. This study examined the relationship between PCB serum levels and risk of NHL in a Northern Italy area (Brescia province), where a chemical factory produced PCBs from 1938 to 1984, causing human contamination. A case–control study of 215 NHL patients and 215 control subjects was conducted. Cases and controls were assayed for serum levels of 33 PCB congeners. No associations were found between risk of NHL and serum levels of total PCBs (OR = 0.51; 95% CI: 0.25–1.04 for highest vs lowest quartile) or specific PCB congeners. The study confirmed a strong association of NHL with HCV infection (OR = 3.60; 95% CI: 1.30–10.02). This case-control study does not support the hypothesis of an association between current serum levels of PCBs and NHL development in the general population.

Published
2019

17. Safety and effectiveness of deep sedation in pediatric patients undergoing flexible fibroscopy in spontaneous breathing

Author

Tosi, F., Conti, G., Festa, R., Mancino, A., Rossi, M., Chiaretti, A., Capossela, L., Gatto, A., Tosi F., Conti G. (ORCID:0000-0002-8566-9365), Mancino A., Rossi M. (ORCID:0000-0002-4539-5670), Chiaretti A. (ORCID:0000-0002-9971-1640), Capossela L., Gatto A., Tosi, F., Conti, G., Festa, R., Mancino, A., Rossi, M., Chiaretti, A., Capossela, L., Gatto, A., Tosi F., Conti G. (ORCID:0000-0002-8566-9365), Mancino A., Rossi M. (ORCID:0000-0002-4539-5670), Chiaretti A. (ORCID:0000-0002-9971-1640), Capossela L., and Gatto A.

Abstract

Invasive diagnostics and minor surgical procedures with deep sedation on pediatric patients, such as fibroscopic examination, have increased over the past decade. The aim of this study was to evaluate the usefulness and safety of an anesthesiological technique, based on the use of midazolam and ketamine, conducted in spontaneous breathing on a population of pediatric patients with suspected tracheobronchial pathologies. Pediatric patients from birth to 18 years old who underwent sedation diagnostic fibroscopy between April 2018 and March 2019, were enrolled. The anesthesiological technique provided was the intravenous administration of midazolam 0.2 mg/kg and ketamine 2 mg/kg in spontaneous breathing using a face mask with support of O2 and air. Vital signs such as Heart rate (HR), Systolic and Diastolic blood pressure (PAS and PAD) and Arterial oxygen saturation were recorded at the beginning of the procedure, 10 minutes and 30 minutes from the start. Other parameter evaluated were patient’s level of consciousness, quality of the procedure, major and minor complications, adequate recovery of the waking state. Sixteen patients were enrolled, 12 males and 4 females aged between 2 days of life and 7 years. Laryngomalacia tracheomalacia, tracheoesophageal fistula, and congenital airway malformations were the most frequent diseases. As for vital signs: the HR has gone from an average value of 133.4 ± 16.26 bpm at T0 to an average value of 129.3 ± 16.55 bpm at T10 and 133.7 ± 17.35 bpm at T30; PAS and PAD had not significant variations. Among drugs available for the fibroscopic examinations, the combined use of intravenous midazolam 0.2 mg/kg and ketamine 2 mg/kg is safe and well tolerated, reducing the anxiety associated with the examination, without major complications. The current literature is lacking in studies that have included such small and low weight patients. It would be interesting to make a comparison between various sedation techniques in order to identify

Published
2021

20. The Prevalence and Association of Different Uropathogens Detected by M-PCR with Infection-Associated Urine Biomarkers in Urinary Tract Infections

Author

Haley E, Luke N, Mathur M, Festa RA, Wang J, Jiang Y, Anderson LA, and Baunoch D

Subjects
diagnostic testing, il-8, il-1β, m-pcr, ngal, uti, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Emery Haley,1 Natalie Luke,1 Mohit Mathur,2 Richard A Festa,3 Jimin Wang,4 Yan Jiang,4 Lori A Anderson,5 David Baunoch3 1Department of Clinical Research, Pathnostics, Irvine, CA, USA; 2Department of Medical Affairs, Pathnostics, Irvine, CA, USA; 3Department of Research and Development, Pathnostics, Irvine, CA, USA; 4Department of Statistical Analysis, Stat4Ward, Pittsburgh, PA, USA; 5L.Anderson Diagnostic Market Access Consulting, San Diego, CA, USACorrespondence: David Baunoch, Pathnostics, 15545 Sand Canyon Suite 100, Irvine, CA, 92618, USA, Tel +1-714-966-1221, Fax +1-714-966-1231, Email dbaunoch@pathnostics.comBackground: Many emerging uropathogens are currently identified by multiplex polymerase chain reaction (M-PCR) in suspected UTI cases. Standard urine culture (SUC) has significantly lower detection rates, raising questions about whether these organisms are associated with UTIs and truly cause inflammation.Objective: To determine if microbes detected by M-PCR were likely causative of UTI by measuring inflammatory biomarkers in the urine of symptomatic patients.Design, Setting, and Participants: Midstream voided urine was collected from subjects ≥ 60 years presenting to urology clinics with symptoms of UTI (n = 1132) between 01/2023 and 05/2023. Microbe detection was by M-PCR and inflammation-associated biomarker (neutrophil gelatinase-associated lipocalin, interleukin 8, and interleukin 1β) was by enzyme-linked immunosorbent assay. Biomarker positivity was measured against individual and groups of organisms, E. coli and non-E. coli cases, emerging uropathogens, monomicrobial and polymicrobial cases.Outcome Measurements and Statistical Analysis: Distributions were compared using 2-sample Wilcoxon Rank Sum test with 2-tailed p-values < 0.05 considered statistically significant.Results and Limitations: M-PCR was positive in 823 (72.7%) specimens with 28 of 30 (93%) microorganisms/groups detected. Twenty-six of twenty-eight detected microorganisms/groups (93%) had ≥ 2 biomarkers positive in > 66% of cases. Both non-E. coli cases and E. coli cases had significant biomarker positivity (p < 0.05). Limitations were that a few organisms had low prevalence making inferences about their individual significance difficult.Conclusion: The majority of microorganisms identified by M-PCR were associated with active inflammation measured by biomarker positivity, indicating they are likely causative of UTIs in symptomatic patients. This includes emerging uropathogens frequently not detected by standard urine culture.Plain Language Summary: The M-PCR assay is a novel diagnostic assay for UTI.This study found that most organisms included in the M-PCR assay were:detected in the urine of patients at least 60 years of age with a presumptive UTI diagnosisassociated with biomarkers of infection and inflammationThus, the M-PCR assay:is clinically relevanthas a low likelihood of false-positivity for UTIKeywords: diagnostic testing, IL-8, IL-1β, M-PCR, NGAL, UTI

Published
2024

22. Emerging and Fastidious Uropathogens Were Detected by M-PCR with Similar Prevalence and Cell Density in Catheter and Midstream Voided Urine Indicating the Importance of These Microbes in Causing UTIs

Author

Wang D, Haley E, Luke N, Mathur M, Festa RA, Zhao X, Anderson LA, Allison JL, Stebbins KL, Diaz MJ, and Baunoch D

Subjects
urinary tract infection, standard urine culture, diagnostic testing, multiplex polymerase chain reaction, catheter, midstream voided, Infectious and parasitic diseases, RC109-216
Abstract

Dakun Wang,1 Emery Haley,2 Natalie Luke,2 Mohit Mathur,3 Richard A Festa,3 Xinhua Zhao,4 Lori A Anderson,5 Jennifer L Allison,6 Kristen L Stebbins,6 Manuel Jose Diaz,6 David Baunoch7 1Department of Writing, Stat4Ward, Pittsburgh, PA, USA; 2Department of Clinical Research, Pathnostics, Irvine, CA, USA; 3Department of Medical Affairs, Pathnostics, Irvine, CA, USA; 4Department of Statistical Analysis, Stat4Ward, Pittsburgh, PA, USA; 5L. Anderson Diagnostic Market Access Consulting, San Diego, CA, USA; 6DispatchHealth, Denver, CO, USA; 7Pathnostics, Irvine, CA, 92618, USACorrespondence: David Baunoch, Pathnostics, 15545 Sand Canyon Suite 100, Irvine, CA, 92618, USA, Tel +1 714-966-1221, Fax +1 714-966-1231, Email dbaunoch@pathnostics.comIntroduction: This study compared microbial compositions of midstream and catheter urine specimens from patients with suspected complicated urinary tract infections to determine if emerging and fastidious uropathogens are infecting the bladder or are contaminants.Methods: Urine was collected by in-and-out catheter (n = 1000) or midstream voiding (n = 1000) from 2000 adult patients (≥ 60 years of age) at 17 DispatchHealth sites across 11 states. The two groups were matched by age (mean 81 years), sex (62.1% female, 37.9% male), and ICD-10-CM codes. Microbial detection was performed with multiplex polymerase chain reaction (M-PCR) with a threshold for “positive detection” ≥ 10,000 cells/mL for bacteria or any detection for yeast. Results were divided by sex.Results: In females, 28 of 30 microorganisms/groups were found by both collection methods, while in males 26 of 30 were found by both. There were significant overlaps in the detection and densities of classical uropathogens including Escherichia coli, Enterococcus faecalis, and Klebsiella pneumoniae, as well as emerging uropathogens including Actinotignum schaalii and Aerococcus urinae. In females, detection rates were slightly higher in midstream voided compared to catheter-collected (p = 0.0005) urine samples, while males showed the opposite trend (p < 0.0001). More polymicrobial infections were detected in midstream voided compared to catheter-collected samples (64.4% vs 45.7%, p < 0.0001) in females but the opposite in males (35.6% vs 47.0%, p = 0.002).Discussion: In-and-out catheter-collected and midstream voided urine specimens shared significant similarities in microbial detections by M-PCR, with some differences found for a small subset of organisms and between sexes.Conclusion: Non-invasive midstream voided collection of urine specimens for microbial detection and identification in cases of presumed UTI does not result in significantly more contamination compared to in-and-out catheter-collected specimens. Additionally, organisms long regarded as contaminants should be reconsidered as potential uropathogens.Keywords: urinary tract infection, standard urine culture, diagnostic testing, multiplex polymerase chain reaction, catheter, midstream voided

Published
2023

23. Assessment of neurological manifestations in hospitalized patients with COVID-19

Author

Luigetti, Marco, Iorio, Raffaele, Bentivoglio, Anna Rita, Tricoli, Luca, Riso, Vittorio, Marotta, Jessica, Piano, Carla, Primiano, Guido Alessandro, Zileri Del Verme, L., Lo Monaco, Maria Rita, Calabresi, Paolo, Abbate, V., Acampora, N., Addolorato, G., Agostini, F., Ainora, M. E., Akacha, K., Amato, E., Andreani, F., Andriollo, G., Annetta, Maria Giuseppina, Annicchiarico, B. E., Antonelli, Massimo, Antonucci, G., Anzellotti, G. M., Armuzzi, A., Baldi, F., Barattucci, I., Barillaro, C., Barone, F., Bellantone, R. D. A., Bellieni, A., Bello, G., Benicchi, A., Benvenuto, F., Berardini, L., Berloco, F., Bernabei, R., Bianchi, A., Biasucci, D. G., Biasucci, L. M., Bibbo, S., Bini, A., Bisanti, A., Biscetti, F., Bocci, M. G., Bonadia, N., Bongiovanni, F., Borghetti, A., Bosco, G., Bosello, Silvia Laura, Bove, V., Bramato, G., Brandi, V., Bruni, T., Bruno, C., Bruno, D., Bungaro, M. C., Buonomo, A., Burzo, L., Calabrese, A., Calvello, M. R., Cambieri, A., Cambise, C., Camma, G., Candelli, M., Canistro, G., Cantanale, A., Capalbo, G., Capaldi, L., Capone, E., Capristo, E., Carbone, L., Cardone, S., Carelli, S., Carfi, A., Carnicelli, A., Caruso, C., Casciaro, F. A., Catalano, L., Cauda, R., Cecchini, A. L., Cerrito, L., Cesarano, M., Chiarito, A., Cianci, Rossella, Cicchinelli, S., Ciccullo, A., Cicetti, M., Ciciarello, F., Cingolani, A., Cipriani, M. C., Consalvo, M. L., Coppola, G., Corbo, G. M., Corsello, A., Costante, F., Costanzi, M., Covino, M., Crupi, D., Cutuli, S. L., D'Addio, S., D'Alessandro, A., D'Alfonso, M. E., D'Angelo, E., D'Aversa, F., Damiano, F., De Berardinis, G. M., De Cunzo, T., De Gaetano, D. K., De Luca, G., De Matteis, G., De Pascale, G., De Santis, P., De Siena, M., De Vito, F., Del Gatto, V., Del Giacomo, P., Del Zompo, F., Dell'Anna, A. M., Della, P. D., Di Gialleonardo, L., Di Giambenedetto, S., Di Luca, R., Di Maurizio, L., Di Muro, M., Dusina, A., Eleuteri, D., Esperide, A., Fachechi, D., Faliero, D., Falsiroli, C., Fantoni, M., Fedele, A., Feliciani, D., Ferrante, C., Ferrone, G., Festa, R., Fiore, M. C., Flex, A., Forte, E., Franceschi, Francesco, Francesconi, A., Franza, L., Funaro, B., Fuorlo, M., Fusco, D., Gabrielli, M., Gaetani, E., Galletta, C., Gallo, A., Gambassi, G., Garcovich, M., Gasbarrini, A., Gasparrini, I., Gelli, S., Giampietro, A., Gigante, L., Giuliano, G., Giupponi, B., Gremese, E., Grieco, Domenico Luca, Guerrera, M., Guglielmi, V., Guidone, C., Gulli, A., Iaconelli, A., Iafrati, A., Ianiro, Gianluca, Iaquinta, A., Impagnatiello, M., Inchingolo, R., Intini, E., Iorio, R., Izzi, I. M., Jovanovic, T., Kadhim, C., La Macchia, R., La Milia, D. I., Landi, F., Landi, G., Landi, R., Landolfi, R., Leo, M., Leone, P. M., Levantesi, L., Liguori, A., Liperoti, R., Lizzio, M. M., Lo Monaco Maria, R., Locantore, P., Lombardi, F., Lombardi, G., Lopetuso, L., Loria, V., Losito, A. R., Lucia, M. B. P., Macagno, F., Macerola, N., Maggi, G., Maiuro, G., Mancarella, F., Mangiola, F., Manno, A., Marchesini, D., Maresca, G. M., Marrone, G., Martis, I., Martone, A. M., Marzetti, Emanuele, Mattana, C., Matteo, M. V., Maviglia, R., Mazzarella, A., Memoli, C., Miele, Luca, Migneco, A., Mignini, I., Milani, A., Milardi, D., Montalto, M., Montemurro, G., Monti, F., Montini, Luca, Morena, T. C., Morra, V., Morretta, C., Moschese, D., Murace, C. A., Murdolo, M., Murri, Rita, Napoli, M., Nardella, E., Natalello, G., Natalini, D., Navarra, S. M., Nesci, A., Nicoletti, A., Nicoletti, R., Nicoletti, T. F., Nicolo, R., Nicolotti, N., Nista, E. C., Nuzzo, E., Oggiano, M., Ojetti, V., Pagano, F. C., Paiano, G., Pais, C., Pallavicini, F., Palombo, A., Paolillo, F., Papa, Alfredo, Papanice, D., Papparella, L. G., Paratore, M., Parrinello, G., Pasciuto, G., Pasculli, P., Pecorini, G., Perniola, S., Pero, E., Petricca, L., Petrucci, M., Picarelli, C., Piccioni, A., Piccolo, A., Piervincenzi, E., Pignataro, G., Pignataro, R., Pintaudi, G., Pisapia, L., Pizzoferrato, M., Pizzolante, F., Pola, R., Policola, C., Pompili, M., Pontecorvi, F., Pontecorvi, V., Ponziani, F., Popolla, V., Porceddu, E., Porfidia, A., Porro, L. M., Potenza, A., Pozzana, F., Privitera, G., Pugliese, D., Pulcini, G., Racco, S., Raffaelli, F., Ramunno, V., Rapaccini, G. L., Richeldi, Luca, Rinninella, Emanuele, Rocchi, S., Romano, B., Romano, S., Rosa, F., Rossi, L., Rossi, R., Rossini, E., Rota, E., Rovedi, F., Rubino, C., Rumi, G., Russo, A., Sabia, L., Salerno, A., Salini, S., Salvatore, L., Samori, D., Sandroni, Claudio, Sanguinetti, M., Santarelli, L., Santini, P., Santolamazza, D., Santoliquido, A., Santopaolo, F., Santoro, M. C., Sardeo, F., Sarnari, C., Saviano, A., Saviano, L., Scaldaferri, Franco, Scarascia, R., Schepis, T., Schiavello, F., Scoppettuolo, G., Sedda, D., Sessa, F., Sestito, L., Settanni, C., Siciliano, M., Siciliano, V., Sicuranza, R., Simeoni, B., Simonetti, J., Smargiassi, A., Soave, P. M., Sonnino, C., Staiti, D., Stella, C., Stella, L., Stival, E., Taddei, E., Talerico, R., Tamburello, E., Tamburrini, E., Tanzarella, E. S., Tarascio, E., Tarli, C., Tersali, A., Tilli, P., Timpano, J., Torelli, E., Torrini, F., Tosato, M., Tosoni, A., Tricoli, L., Tritto, M., Tumbarello, M., Tummolo, A. M., Vallecoccia, M. S., Valletta, F., Varone, F., Vassalli, F., Ventura, G., Verardi, L., Vetrone, L., Vetrugno, G., Visconti, E., Visconti, F., Viviani, A., Zaccaria, R., Zaccone, C., Zelano, L., Zileri Dal Verme, L., Zuccala, G., Luigetti M. (ORCID:0000-0001-7539-505X), Iorio R. (ORCID:0000-0002-6270-0956), Bentivoglio A. R. (ORCID:0000-0002-9663-095X), Tricoli L., Riso V., Marotta J., Piano C., Primiano G., Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Calabresi P. (ORCID:0000-0003-0326-5509), Annetta M. G. (ORCID:0000-0001-7574-1311), Antonelli M. (ORCID:0000-0003-3007-1670), Bosello S. (ORCID:0000-0002-4837-447X), Cianci R. (ORCID:0000-0001-5378-8442), Franceschi F. (ORCID:0000-0001-6266-445X), Grieco D. L. (ORCID:0000-0002-4557-6308), Ianiro G. (ORCID:0000-0002-8318-0515), Marzetti E. (ORCID:0000-0001-9567-6983), Miele L. (ORCID:0000-0003-3464-0068), Montini L. (ORCID:0000-0003-4602-5134), Murri R. (ORCID:0000-0003-4263-7854), Papa A. (ORCID:0000-0002-4186-7298), Richeldi L. (ORCID:0000-0001-8594-1448), Rinninella E. (ORCID:0000-0002-9165-2367), Sandroni C. (ORCID:0000-0002-8878-2611), Scaldaferri F. (ORCID:0000-0001-8334-7541), Luigetti, Marco, Iorio, Raffaele, Bentivoglio, Anna Rita, Tricoli, Luca, Riso, Vittorio, Marotta, Jessica, Piano, Carla, Primiano, Guido Alessandro, Zileri Del Verme, L., Lo Monaco, Maria Rita, Calabresi, Paolo, Abbate, V., Acampora, N., Addolorato, G., Agostini, F., Ainora, M. E., Akacha, K., Amato, E., Andreani, F., Andriollo, G., Annetta, Maria Giuseppina, Annicchiarico, B. E., Antonelli, Massimo, Antonucci, G., Anzellotti, G. M., Armuzzi, A., Baldi, F., Barattucci, I., Barillaro, C., Barone, F., Bellantone, R. D. A., Bellieni, A., Bello, G., Benicchi, A., Benvenuto, F., Berardini, L., Berloco, F., Bernabei, R., Bianchi, A., Biasucci, D. G., Biasucci, L. M., Bibbo, S., Bini, A., Bisanti, A., Biscetti, F., Bocci, M. G., Bonadia, N., Bongiovanni, F., Borghetti, A., Bosco, G., Bosello, Silvia Laura, Bove, V., Bramato, G., Brandi, V., Bruni, T., Bruno, C., Bruno, D., Bungaro, M. C., Buonomo, A., Burzo, L., Calabrese, A., Calvello, M. R., Cambieri, A., Cambise, C., Camma, G., Candelli, M., Canistro, G., Cantanale, A., Capalbo, G., Capaldi, L., Capone, E., Capristo, E., Carbone, L., Cardone, S., Carelli, S., Carfi, A., Carnicelli, A., Caruso, C., Casciaro, F. A., Catalano, L., Cauda, R., Cecchini, A. L., Cerrito, L., Cesarano, M., Chiarito, A., Cianci, Rossella, Cicchinelli, S., Ciccullo, A., Cicetti, M., Ciciarello, F., Cingolani, A., Cipriani, M. C., Consalvo, M. L., Coppola, G., Corbo, G. M., Corsello, A., Costante, F., Costanzi, M., Covino, M., Crupi, D., Cutuli, S. L., D'Addio, S., D'Alessandro, A., D'Alfonso, M. E., D'Angelo, E., D'Aversa, F., Damiano, F., De Berardinis, G. M., De Cunzo, T., De Gaetano, D. K., De Luca, G., De Matteis, G., De Pascale, G., De Santis, P., De Siena, M., De Vito, F., Del Gatto, V., Del Giacomo, P., Del Zompo, F., Dell'Anna, A. M., Della, P. D., Di Gialleonardo, L., Di Giambenedetto, S., Di Luca, R., Di Maurizio, L., Di Muro, M., Dusina, A., Eleuteri, D., Esperide, A., Fachechi, D., Faliero, D., Falsiroli, C., Fantoni, M., Fedele, A., Feliciani, D., Ferrante, C., Ferrone, G., Festa, R., Fiore, M. C., Flex, A., Forte, E., Franceschi, Francesco, Francesconi, A., Franza, L., Funaro, B., Fuorlo, M., Fusco, D., Gabrielli, M., Gaetani, E., Galletta, C., Gallo, A., Gambassi, G., Garcovich, M., Gasbarrini, A., Gasparrini, I., Gelli, S., Giampietro, A., Gigante, L., Giuliano, G., Giupponi, B., Gremese, E., Grieco, Domenico Luca, Guerrera, M., Guglielmi, V., Guidone, C., Gulli, A., Iaconelli, A., Iafrati, A., Ianiro, Gianluca, Iaquinta, A., Impagnatiello, M., Inchingolo, R., Intini, E., Iorio, R., Izzi, I. M., Jovanovic, T., Kadhim, C., La Macchia, R., La Milia, D. I., Landi, F., Landi, G., Landi, R., Landolfi, R., Leo, M., Leone, P. M., Levantesi, L., Liguori, A., Liperoti, R., Lizzio, M. M., Lo Monaco Maria, R., Locantore, P., Lombardi, F., Lombardi, G., Lopetuso, L., Loria, V., Losito, A. R., Lucia, M. B. P., Macagno, F., Macerola, N., Maggi, G., Maiuro, G., Mancarella, F., Mangiola, F., Manno, A., Marchesini, D., Maresca, G. M., Marrone, G., Martis, I., Martone, A. M., Marzetti, Emanuele, Mattana, C., Matteo, M. V., Maviglia, R., Mazzarella, A., Memoli, C., Miele, Luca, Migneco, A., Mignini, I., Milani, A., Milardi, D., Montalto, M., Montemurro, G., Monti, F., Montini, Luca, Morena, T. C., Morra, V., Morretta, C., Moschese, D., Murace, C. A., Murdolo, M., Murri, Rita, Napoli, M., Nardella, E., Natalello, G., Natalini, D., Navarra, S. M., Nesci, A., Nicoletti, A., Nicoletti, R., Nicoletti, T. F., Nicolo, R., Nicolotti, N., Nista, E. C., Nuzzo, E., Oggiano, M., Ojetti, V., Pagano, F. C., Paiano, G., Pais, C., Pallavicini, F., Palombo, A., Paolillo, F., Papa, Alfredo, Papanice, D., Papparella, L. G., Paratore, M., Parrinello, G., Pasciuto, G., Pasculli, P., Pecorini, G., Perniola, S., Pero, E., Petricca, L., Petrucci, M., Picarelli, C., Piccioni, A., Piccolo, A., Piervincenzi, E., Pignataro, G., Pignataro, R., Pintaudi, G., Pisapia, L., Pizzoferrato, M., Pizzolante, F., Pola, R., Policola, C., Pompili, M., Pontecorvi, F., Pontecorvi, V., Ponziani, F., Popolla, V., Porceddu, E., Porfidia, A., Porro, L. M., Potenza, A., Pozzana, F., Privitera, G., Pugliese, D., Pulcini, G., Racco, S., Raffaelli, F., Ramunno, V., Rapaccini, G. L., Richeldi, Luca, Rinninella, Emanuele, Rocchi, S., Romano, B., Romano, S., Rosa, F., Rossi, L., Rossi, R., Rossini, E., Rota, E., Rovedi, F., Rubino, C., Rumi, G., Russo, A., Sabia, L., Salerno, A., Salini, S., Salvatore, L., Samori, D., Sandroni, Claudio, Sanguinetti, M., Santarelli, L., Santini, P., Santolamazza, D., Santoliquido, A., Santopaolo, F., Santoro, M. C., Sardeo, F., Sarnari, C., Saviano, A., Saviano, L., Scaldaferri, Franco, Scarascia, R., Schepis, T., Schiavello, F., Scoppettuolo, G., Sedda, D., Sessa, F., Sestito, L., Settanni, C., Siciliano, M., Siciliano, V., Sicuranza, R., Simeoni, B., Simonetti, J., Smargiassi, A., Soave, P. M., Sonnino, C., Staiti, D., Stella, C., Stella, L., Stival, E., Taddei, E., Talerico, R., Tamburello, E., Tamburrini, E., Tanzarella, E. S., Tarascio, E., Tarli, C., Tersali, A., Tilli, P., Timpano, J., Torelli, E., Torrini, F., Tosato, M., Tosoni, A., Tricoli, L., Tritto, M., Tumbarello, M., Tummolo, A. M., Vallecoccia, M. S., Valletta, F., Varone, F., Vassalli, F., Ventura, G., Verardi, L., Vetrone, L., Vetrugno, G., Visconti, E., Visconti, F., Viviani, A., Zaccaria, R., Zaccone, C., Zelano, L., Zileri Dal Verme, L., Zuccala, G., Luigetti M. (ORCID:0000-0001-7539-505X), Iorio R. (ORCID:0000-0002-6270-0956), Bentivoglio A. R. (ORCID:0000-0002-9663-095X), Tricoli L., Riso V., Marotta J., Piano C., Primiano G., Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Calabresi P. (ORCID:0000-0003-0326-5509), Annetta M. G. (ORCID:0000-0001-7574-1311), Antonelli M. (ORCID:0000-0003-3007-1670), Bosello S. (ORCID:0000-0002-4837-447X), Cianci R. (ORCID:0000-0001-5378-8442), Franceschi F. (ORCID:0000-0001-6266-445X), Grieco D. L. (ORCID:0000-0002-4557-6308), Ianiro G. (ORCID:0000-0002-8318-0515), Marzetti E. (ORCID:0000-0001-9567-6983), Miele L. (ORCID:0000-0003-3464-0068), Montini L. (ORCID:0000-0003-4602-5134), Murri R. (ORCID:0000-0003-4263-7854), Papa A. (ORCID:0000-0002-4186-7298), Richeldi L. (ORCID:0000-0001-8594-1448), Rinninella E. (ORCID:0000-0002-9165-2367), Sandroni C. (ORCID:0000-0002-8878-2611), and Scaldaferri F. (ORCID:0000-0001-8334-7541)

Abstract

Background and purpose: The objective of this study was to assess the neurological manifestations in a series of consecutive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients, comparing their frequency with a population hospitalized in the same period for flu/respiratory symptoms, finally not related to SARS-CoV-2. Methods: Patients with flu/respiratory symptoms admitted to Fondazione Policlinico Gemelli hospital from 14 March 2020 to 20 April 2020 were retrospectively enrolled. The frequency of neurological manifestations of patients with SARS-CoV-2 infection was compared with a control group. Results: In all, 213 patients were found to be positive for SARS-CoV-2, after reverse transcriptase polymerase chain reaction on nasal or throat swabs, whilst 218 patients were found to be negative and were used as a control group. Regarding central nervous system manifestations, in SARS-CoV-2-positive patients a higher frequency of headache, hyposmia and encephalopathy always related to systemic conditions (fever or hypoxia) was observed. Furthermore, muscular involvement was more frequent in SARS-CoV-2 infection. Conclusions: Patients with COVID-19 commonly have neurological manifestations but only hyposmia and muscle involvement seem more frequent compared with other flu diseases.

Published
2020

24. Plasma levels of polychlorinated biphenyls and risk of cutaneous malignant melanoma: A hospital-based case-control study

Author

Magoni, M, Apostoli, P, Donato, F, Manganoni, A, Comba, P, Fazzo, L, Speziani, F, Leonardi, L, Orizio, G, Scarcella, C, Calzavara Pinton, P, Terraroli, C, Coniglio, A, Zarattini, G, Manca, G, Fostinelli, J, Festa, R, Conti, M, and Micheletti, S

Subjects
Risk, Skin Neoplasms, Population, Physiology, 010501 environmental sciences, 01 natural sciences, Environmental risk factors, Melanoma, Polychlorinated biphenyls, 2300, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, education, lcsh:Environmental sciences, 0105 earth and related environmental sciences, General Environmental Science, lcsh:GE1-350, education.field_of_study, business.industry, Case-control study, Cancer, Hospital based, Plasma levels, medicine.disease, Control subjects, Quartile, Case-Control Studies, 030220 oncology & carcinogenesis, business
Abstract

Polychlorinated biphenyls (PCB) have been classified by the International Agency for Research on Cancer (IARC) in Group 1 as carcinogenic to human, based on sufficient evidence in humans of an increased risk of cutaneous malignant melanoma (CMM), however few studies have been done in the general population. This study examined the relationship between PCB plasma levels and risk of CMM adjusting for sun sensitivity and sun exposure in a province of Northern Italy (Brescia), where a chemical factory produced PCBs from 1938 to 1984 causing human contamination. A case–control study of 205 CMM patients and 205 control subjects was conducted. Cases and controls were assayed for plasma levels of 33 PCB congeners. No associations was found between risk of CMM and plasma levels of total PCB (OR = 0.81; 95% CI: 0.34–1.96 for highest vs lowest quartile) or specific congeners. The study confirmed the association with light skin colour (OR = 3.00; 95% CI: 1.91–4.73), cumulative lifetime UV exposure (OR = 2.56; 95% CI: 1.35–4.85) and high level of education (OR = 1.45; 95% CI: 1.03–2.05). This case-control study does not support the hypothesis of an association between current plasma levels of PCBs and CMM development in the general population. Keywords: Melanoma, Polychlorinated biphenyls, Environmental risk factors

Published
2018

30. Physical models, part 2

Author

Noia, M., Ratto, C.F., and Festa, R.

Subjects
Solar radiation -- Measurement, Geostationary satellites -- Usage, Earth sciences, Petroleum, energy and mining industries
Abstract

The use of satellite data to estimate solar irradiance at ground level represents a valid alternative to ground measurements of solar radiation. This paper continues the analysis and evaluation, started in a previous paper, of the best known methods for calculating solar irradiance at the earth's surface using geostationary satellite data. In the previous paper, we examined and compared the so-called statistical models. Now we will consider the physical models and point out the differences between them. Finally, a summary will be made of the assessments and comparisons carried out on the methods described.

Published
1993

31. Statistical models, part 1

Author

Noia, M., Ratto, C.F., and Festa, R.

Subjects
Geostationary satellites -- Usage, Solar radiation -- Measurement, Statistics -- Models, Earth sciences, Petroleum, energy and mining industries
Abstract

The use of satellite data to estimate solar irradiance at ground level represents a valid alternative to ground measurements of solar radiation. The best known methods of estimating the solar irradiance at the earth's surface using geostationary satellite data are reviewed. The models may be classified into statistical and physical models, depending on the approach used to treat the interaction between solar radiation and atmosphere. The main hypotheses and algorithms used in four statistical models are extensively presented and discussed. The differences between these methods are pointed out. Physical models will be examined in a second paper. This second paper will include various assessments regarding the performances of the described methods and summaries of comparisons between the different models.

Published
1993

32. Thermal design and experimental analysis of laser and electron beam hardening

Author

Festa, R., Nenci, F., Manca, O., and Naso, V.

Subjects
Laser beams -- Research, Electron beams -- Research, Engineering and manufacturing industries, Science and technology
Abstract

Dimensionless correlations for an easy prediction of the hardened depth in electron and laser beam heating treatments are derived from two analytical thermal models. Electron beam heat treating is carried out on 9Cr-2Mo and C40 steels. Effects of the translation speed and the spot dimensions were taken into account. The fairly good agreement between analytical and experimental data suggests that the proposed correlations can be used in applications.

Published
1993

33. Proposal of a numerical procedure to select reference years

Author

Festa, R. and Ratto, C.F.

Subjects
Meteorology -- Observations, Meteorological research -- Analysis, Earth sciences, Petroleum, energy and mining industries
Abstract

A procedure is presented which can be used to create, from many years of available past weather data, a Reference Year consisting in 8760 hourly values of a few chosen meteorological quantities. Such 'year' corresponds to a 'typical' year for the considered locality, regarding both the occurrence and the persistence of different meteorological situations, in all months. This approach is a modification of the procedure used in the production of Test Reference Years or of Design Reference Years. In this approach, the frequency distributions relative to single months in the database are compared with the long-term frequency distribution of all the months 'with the same name.' Furthermore, the correlation between subsequent daily values is taken into account.

Published
1993

34. Una paura sempre verde

Author

Festa, R. and Festa, R.

Subjects
ecologismo radicale, olismo, rapporto uomo-natura
Abstract

Vengono analizzate le illusioni olistiche dell’ecologismo totalitario. L’olismo – tra i cui padri vanno annoverati filosofi come Platone, Hegel e Marx –, non è altro che una pseudoscienza fondata sull’illusoria pretesa di fornire una spiegazione globale di sistemi complessi come le società umane. Diversamente dall’ecologia, che è una scienza rispettabile, e quindi altamente congetturale e fallibile, l’ecologismo è un’ideologia olistica che, mentre pretende di fondarsi sull’ecologia, ne stravolge interamente il metodo.

Published
2017

35. Risk vs Logic. Karl Barth and Heinrich Scholz on Faith and Reason

Author

Abrusci, M., Arrigoni, T., Buzzoni, M., Carrara, M., Festa, R., Cevolani, G., Corradini, A., De Florio, C., Fossati, L., Frigerio, A., Galavotti, M.C., Gasser, G., Giordani, A., von Kutschera, F., Lenzen, W., Löffler, W., Mancosu, P., Meixner, U., Nicolai, C., Runggaldier, E., Schurz, G., Adams, E., Fossati, Lorenzo, Fossati lorenzo (ORCID:0000-0003-2802-1092), Abrusci, M., Arrigoni, T., Buzzoni, M., Carrara, M., Festa, R., Cevolani, G., Corradini, A., De Florio, C., Fossati, L., Frigerio, A., Galavotti, M.C., Gasser, G., Giordani, A., von Kutschera, F., Lenzen, W., Löffler, W., Mancosu, P., Meixner, U., Nicolai, C., Runggaldier, E., Schurz, G., Adams, E., Fossati, Lorenzo, and Fossati lorenzo (ORCID:0000-0003-2802-1092)

Abstract

The paper analyses a few questions of Heinrich Scholz on Karl Barth’s dialectic theology: is it possible to view theology as a science? What is the meaning of a «theological proposition»? Which minimal formal constraints of meaningfulness shared with other sciences shall be observed in theological research? These issues are the necessary prerequisites for any rational discourse, hence for questions related to faith.

Published
2018

37. Functional Explanation in Biology

Author

Wouters, A.G., Festa, R., Aliseda, A., Peijnenburg, J., Festa, R., Aliseda, A., and Peijnenburg, J.

Subjects
Interactie van wereldbeelden, mensbeelden en godsbeelden, Monographs in debate
Abstract

Item does not contain fulltext

Published
2005

41. [Cumulative exposure to polychlorodibenzo-p-dioxins (PCDDS), polychlorodibenzofurans (PCDFS) and polychlorobiphenyls (PCB) in the metallurgic workers and the general population in Brescia province, northern Italy]

Author

Pg, Barbieri, Garattini S, Pizzoni T, Festa R, Abballe A, Marra V, Iacovella N, Am, Ingelido, Silvia Valentini, and De Felip E

Subjects
Male, Polychlorinated Dibenzodioxins, Italy, Polymers, Occupational Exposure, Metallurgy, Humans, Environmental Pollutants, Environmental Exposure, Benzofurans
Abstract

High temperature metallurgical processes may significantly contribute to the release of polychlorodibenzo-p-dioxins (PCDDs) and polychlorodibenzofurans (PCDFs) into the environment. Aim of this study was to evaluate the exposure to PCDDs, PCDFs, dioxin-like PCBs (DL-PCBs) and non dioxin-like PCBs (NDL-PCBs) in a sample of 300 workers of metallurgical plants operating in the Brescia area and in a control group of 113 men. Serum samples were grouped in pools of 10 and analyzed for their concentration of PCDDs and PCDFs, DL- and NDL-PCBs. Metallurgical workers show serum concentrations of NDL-PCBs similar to those observed in non-occupationally exposed living in Brescia, except in the case of some congeners, such as PCBs 28, 52, 101 which result to be significantly higher in metallurgical workers. Their concentrations range of "dioxins" was of 32.5 - 84.8 pgTEQ g(-1) lb. No significant difference was found between metallurgical workers and the control group on the whole, but the difference became significant when comparing metallurgical workers with the group of the 47 subjects living in remote non industrialised areas. In conclusion, concentrations of total PCBs observed in metallurgy workers are comparable with those observed in the control group, with the exception of a few, more volatile, congeners which resulted to be higher in metallurgy workers. Concentrations of PCDDs and PCDFs showed a range of values similar to that observed in the general population of Brescia not professionally exposed. However, concentrations of PCDDs and PCDFs observed in subjects resident in "remote" areas were significantly lower than those assessed in metallurgy workers and subjects living in the town of Brescia. On the whole, men living in the town of Brescia show levels of PCBs, PCDDs and PCDFs higher than those observed in other groups of the Italian general population, this reflecting the intense industrial activity of the town.

Published
2012

42. Morphological parameters of flat epithelial atypia (FEA) in stereotactic vacuum-assisted needle core biopsies do not predict the presence of malignancy on subsequent surgical excision

Author

Bianchi, S, Bendinelli, B, Castellano, I, Piubello, Quirino, Renne, G, Cattani, Mg, Di Stefano, D, Carrillo, G, Laurino, L, Bersiga, A, Giardina, C, Dante, S, Di Loreto, C, Quero, C, Antonacci, Cm, Palli, D, VANCB Study Group, Ferrero, G, Piubello, Q, Querzoli, P, Sapino, A, Vezzosi, V, Amadori, S, Ambrogetti, D, Balestrieri, N, Bazzocchi, M, Bodini, Mt, Cassano, E, Durando, M, Festa, R, Guerrieri, Am, Maggian, P, Mariscotti, G, Mattei, M, Montemezzi, Stefania, Saguatti, G, Scalabrin, U, Trasente, I, and Ventrella, V.

Subjects
Pathology, medicine.medical_specialty, Vacuum, Breast, Flat epithelial atypia, Stereotactic vacuum-assisted needle core biopsy, Surgical excision, Malignancy, Biopsy, diagnosis/pathology, Breast Neoplasms, Malignancy, NO, methods, Pathology and Forensic Medicine, Stereotaxic Techniques, Breast cancer, Predictive Value of Tests, Ductal, medicine, Atypia, Carcinoma, Humans, Clinical significance, Breast, Molecular Biology, Large-Core Needle, methods, Breast Neoplasms, diagnosis/pathology, Breast, pathology, Carcinoma in Situ, diagnosis/pathology, Carcinoma, diagnosis/pathology, Epithelial Cells, pathology, Female, Humans, Hyperplasia, diagnosis/pathology, Logistic Models, Middle Aged, Predictive Value of Tests, Stereotaxic Techniques, Vacuum, Hyperplasia, medicine.diagnostic_test, business.industry, Stereotactic vacuum-assisted needle core biopsy, Carcinoma, Ductal, Breast, Surgical excision, Epithelial Cells, Cell Biology, General Medicine, Middle Aged, medicine.disease, Flat epithelial atypia, Logistic Models, Predictive value of tests, Stereotaxic technique, pathology, Female, Biopsy, Large-Core Needle, Breast, Flat epithelial atypia, Malignancy, Stereotactic vacuum-assisted needle core biopsy, Surgical excision, business, Carcinoma in Situ
Abstract

Flat epithelial atypia (FEA) may represent the earliest precursor of low-grade breast cancer and often coexists with more advanced atypical proliferative breast lesions such as atypical ductal hyperplasia (ADH) and lobular intraepithelial neoplasia (LIN). The present study aims to investigate the association between morphological parameters of FEA and presence of malignancy at surgical excision (SE) and the clinical significance of the association of FEA with ADH and/or LIN. This study included 589 cases of stereotactic 11-gauge vacuum-assisted needle core biopsy (VANCB), reporting a diagnosis of FEA, ADH or LIN with subsequent SE from 14 pathology departments in Italy. Available slides were reviewed, with 114 (19.4 %) showing a malignant outcome at SE. Among the 190 cases of pure FEA, no statistically significant association emerged between clinical–pathological parameters of FEA and risk of malignancy. Logistic regression analyses showed an increased risk of malignancy according to the extension of ADH among the 275 cases of FEA associated with ADH (p = 0.004) and among the 34 cases of FEA associated with ADH and LIN (p = 0.02). In the whole series, a statistically significant increased malignancy risk emerged according to mammographic R1–R3/R4–R5 categories (OR = 1.56; p = 0.04), extension (OR = 1.24; p = 0.04) and grade (OR = 1.94; p = 0.004) of cytological atypia of FEA. The presence of ADH was associated with an increased malignancy risk (OR = 2.85; p < 0.0001). Our data confirm the frequent association of FEA with ADH and/or LIN. A diagnosis of pure FEA on VANCB carries a 9.5 % risk of concurrent malignancy and thus warrants follow-up excision because none of the clinical–pathological parameters predicts which cases will present carcinoma on SE.

Published
2012

45. Positive predictive value for malignancy on surgical excision of breast lesions of uncertain malignant potential (B3) diagnosed by stereotactic vacuum-assisted needle core biopsy (VANCB): a large multi-institutional study in Italy

Author

Bianchi, S, Caini, S, Renne, G, Cassano, E, Ambrogetti, D, Cattani, Mg, Saguatti, G, Chiaramondia, M, Bellotti, E, Bottiglieri, R, Ancona, A, Piubello, Q, Montemezzi, S, Ficarra, G, Mauri, C, Zito, Fa, Ventrella, V, Baccini, P, Calabrese, M, Palli, D, Antonacci, Cm, Bersiga, A, Carli, F, Carrillo, G, Castellano, Isabella, Dante, S, Di Loreto, C, Di Stefano, D, Fanelli, G, Ferrero, G, Galasso, Mg, Giardina, E, Grillo, L, Laurino, L, Naccarato, G, Querzoli, P, Sapino, Anna, Vezzosi, V, Amadori, S, Balestrieri, N, Bazzocchi, M, Belotti, E, Cilotti, A, Corcione, S, Durando, M, Faedda, C, Festa, R, Guerrieri, A, Ingianna, D, Maggian, P, Mariscotti, G, Massa, T, Mattei, M, Rizzo, Mf, Scalabrin, U, Trasente, I, and Ventrella, V.

Subjects
medicine.medical_specialty, Positive predictive value, Percutaneous, B3 lesions, Positive predictive value, Surgical excision, Stereotactic vacuum-assisted needle core biopsy, Non-palpable lesion, Breast, B3 lesions, Breast, Non-palpable lesion, Positive predictive value, Stereotactic vacuum-assisted needle core biopsy, Surgical excision, B3 lesions, Surgical excision, Stereotactic vacuum-assisted needle core biopsy, Non-palpable lesion, Breast, Breast Neoplasms, Malignancy, NO, Text mining, Predictive Value of Tests, Biopsy, medicine, Humans, Early Detection of Cancer, Retrospective Studies, medicine.diagnostic_test, business.industry, Biopsy, Needle, Retrospective cohort study, Stereotactic vacuum-assisted needle core, General Medicine, medicine.disease, Italy, Predictive value of tests, Radiological weapon, Surgery, Female, Radiology, business
Abstract

Percutaneous core biopsy (CB) has been introduced to increase the ability of accurately diagnosing breast malignancies without the need of resorting to surgery. Compared to conventional automated 14 gauge needle core biopsy (NCB), vacuum-assisted needle core biopsy (VANCB) allows obtaining larger specimens and has recognized advantages particularly when the radiological pattern is represented by microcalcifications. Regardless of technical improvements, a small percentage of percutaneous CBs performed to detect breast lesions are still classified, according to European and UK guidelines, in the borderline B3 category, including a group of heterogeneous lesions with uncertain malignant potential. We aimed to assess the prevalence and positive predictive values (PPV) on surgical excision (SE) of B3 category (overall and by sub-categories) in a large series of non-palpable breast lesions assessed through VANCB, also comparison with published data on CB. Overall, 26,165 consecutive stereotactic VANCB were identified in 22 Italian centres: 3107 (11.9%) were classified as B3, of which 1644 (54.2%) proceeded to SE to establish a definitive histological diagnosis of breast pathology. Due to a high proportion of microcalcifications as main radiological pattern, the overall PPV was 21.2% (range 10.6%-27.3% for different B3 subtypes), somewhat lower than the average value (24.5%) from published studies (range 9.9%-35.1%). Our study, to date the largest series of B3 with definitive histological assessment on SE, suggests that B3 lesions should be referred for SE even if VANCB is more accurate than NCB in the diagnostic process of non-palpable, sonographically invisible breast lesions.

Published
2011

47. The Whole Truth about Linda: Probability, Verisimilitude and a Paradox of Conjunction

Author

Cevolani, Gustavo, Crupi, Vincenzo, Festa, R., M. D’Agostino et al. (a cura di), Festa, Roberto, Cevolani, G, and Crupi, Vincenzo

Subjects
Paradox of Conjunction, Verisimilitude, Probability
Abstract

The logical problem of verisimilitude amounts to the preliminary definition of an appropriate notion of verisimilitude, allowing for a comparison of any two hypotheses with regards to their closeness to the truth. The epistemic problem of verisimilitude, on the other hand, amounts to the definition of an appropriate notion of expected verisimilitude by which the estimated closeness to the truth of any two hypotheses could be compared on the basis of the available data. We will outline the formal background to briefly address both problems in turn, introducing the basic traits of a theory of verisimilitude and expected verisimilitude for hypotheses expressed in a propositional language. Then, we will come back to the conjunction paradox and provide a novel verisimilitudinarian analysis of the Linda’s story and the paradox of conjunction.

Published
2011

49. Coenzyme Q10 supplementation in infertile men with low-grade varicocele: an open, uncontrolled pilot study.

Author

Festa, R, Giacchi Mancini, Elena Teresa Carmela, Raimondo, Sebastiano, Tiano, L, Zuccarelli, P, Silvestrini, Andrea, Meucci Calabrese, Elisabetta, Littarru, Gp, Mancini, Antonio, Giacchi E, Raimondo S, Silvestrini A (ORCID:0000-0002-2005-3746), Meucci E (ORCID:0000-0002-8821-8041), Mancini A. (ORCID:0000-0002-7707-4564), Festa, R, Giacchi Mancini, Elena Teresa Carmela, Raimondo, Sebastiano, Tiano, L, Zuccarelli, P, Silvestrini, Andrea, Meucci Calabrese, Elisabetta, Littarru, Gp, Mancini, Antonio, Giacchi E, Raimondo S, Silvestrini A (ORCID:0000-0002-2005-3746), Meucci E (ORCID:0000-0002-8821-8041), and Mancini A. (ORCID:0000-0002-7707-4564)

Abstract

Many conditions associated with male infertility are inducers of oxidative stress, including varicocele. Antioxidants, such as coenzyme Q10, may be useful in this case. To evaluate the antioxidant capacity of seminal plasma of infertile men with varicocele before and after an oral supplementation with coenzyme Q10 , 38 patients were recruited from a pilot clinical trial. A standard semen analysis was also performed at baseline and 3 months after an oral supplementation with exogenous coenzyme Q10 100 mg per die. Seminal plasma antioxidant capacity was measured using a spectroscopic method. Coenzyme Q10 therapy improved semen parameters and antioxidant status. This study highlights the importance of oxidative stress in the pathogenesis of male infertility, namely in varicocele, and strengthens the possibility of the usefulness of the antioxidant therapy.

Published
2014

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