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4. Quality care close to home: Objectives and early outcomes of a second paediatric heart transplant service in Australia.

Author

Basu, S, Irving, C, Roberts, P, Orr, Y, Reilly, C, Casey, C, Griffiths, A, Oake, D, McElduff, M, Macdonald, P, Nair, P, Jansz, P, Festa, M, Basu, S, Irving, C, Roberts, P, Orr, Y, Reilly, C, Casey, C, Griffiths, A, Oake, D, McElduff, M, Macdonald, P, Nair, P, Jansz, P, and Festa, M

Abstract

AIM: We describe the experience of a new paediatric heart transplant (HT) centre in Australia. New South Wales offers quaternary paediatric cardiac services including comprehensive care pre- and post-HT; however, perioperative HT care has previously occurred at the national paediatric centre or in adult centres. Internationally, perioperative HT care is highly protocol-driven and a majority of HT occurs in low volume centres. Establishing a low volume paediatric HT centre in New South Wales offers potential for quality HT care close to home. METHODS: Retrospective review of programme data for the first 12 months was undertaken. Patient selection was audited against the programme's intended initiation criteria. Longitudinal patient data on outcomes and complications were obtained from patient medical records. RESULTS: The programme's initial phase offered HT to children with non-congenital heart disease and no requirement for durable mechanical circulatory support. Eight patients met criteria for HT referral. Three underwent interstate transfer to the national paediatric centre. Five children (13-15 years, weight 36-85 kg) underwent HT in the new programme. Individual predicted 90-day mortality was 1.3-11.6%, with increased risk for recipients transplanted from veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and with restrictive/hypertrophic cardiomyopathies. Survival at 90 days and for duration of follow-up is 100%. Observed programme benefits include mitigation of family dislocation and improved continuity of care within a family-centred programme. CONCLUSION: Audit of the first 12 months' activity of a second paediatric HT centre in Australia demonstrates adherence to proposed patient selection criteria and excellent 90-day patient outcomes. The programme demonstrates feasibility of care close to home, providing continuity for all patients including those requiring increased rehabilitation and psychosocial support post-transplantation.

Published
2023

6. Cardiovascular active peptides of marine origin with ACE inhibitory activities: Potential role as anti-hypertensive drugs and in prevention of SARSCoV-2 infection

Author

Festa, M, Sansone, C, Brunet, C, Crocetta, F, Di Paola, L, Lombardo, M, Bruno, A, Noonan, D, Albini, A, Festa M., Sansone C., Brunet C., Crocetta F., Di Paola L., Lombardo M., Bruno A., Noonan D. M., Albini A., Festa, M, Sansone, C, Brunet, C, Crocetta, F, Di Paola, L, Lombardo, M, Bruno, A, Noonan, D, Albini, A, Festa M., Sansone C., Brunet C., Crocetta F., Di Paola L., Lombardo M., Bruno A., Noonan D. M., and Albini A.

Abstract

Growing interest in hypertension—one of the main factors characterizing the cardiometabolic syndrome (CMS)—and anti-hypertensive drugs raised from the emergence of a new coronavirus, SARS-CoV-2, responsible for the COVID19 pandemic. The virus SARS-CoV-2 employs the Angiotensin-converting enzyme 2 (ACE2), a component of the RAAS (Renin- Angiotensin-Aldosterone System) system, as a receptor for entry into the cells. Several classes of synthetic drugs are available for hypertension, rarely associated with severe or mild adverse effects. New natural compounds, such as peptides, might be useful to treat some hypertensive patients. The main feature of ACE inhibitory peptides is the location of the hydrophobic residue, usually Proline, at the C-terminus. Some already known bioactive peptides derived from marine resources have potential ACE inhibitory activity and can be considered therapeutic agents to treat hypertension. Peptides isolated from marine vertebrates, invertebrates, seaweeds, or sea microorganisms displayed important biological activities to treat hypertensive patients. Here, we reviewed the antihypertensive activities of bioactive molecules isolated/extracted from marine organisms and discussed the associated molecular mechanisms involved. We also examined ACE2 modulation in sight of SARS2-Cov infection prevention.

Published
2020

7. An extract of olive mill wastewater downregulates growth, adhesion and invasion pathways in lung cancer cells: Involvement of CXCR4

Author

Gallazzi, M, Festa, M, Corradino, P, Sansone, C, Albini, A, Noonan, D, Gallazzi M., Festa M., Corradino P., Sansone C., Albini A., Noonan D. M., Gallazzi, M, Festa, M, Corradino, P, Sansone, C, Albini, A, Noonan, D, Gallazzi M., Festa M., Corradino P., Sansone C., Albini A., and Noonan D. M.

Abstract

Several diet-derived compounds have been reported to exert antioxidant, anti-proliferative and anti-angiogenic effects in numerous cancers and could be beneficial in cancer prevention. Olive oil production involves the generation of an aqueous phase defined as olive mill wastewater (OMWW), a polluting effluent rich in soluble polyphenols. Here, we assessed the cancer preventive properties exerted by a purified extract of OMWW (A009) for its activity on lung cancer cell lines. Hydroxytyrosol, the most abundant polyphenol present in our A009 extracts, was used as reference molecule in the assays performed. Extracts from OMWW from two different olive oil cultivars were used. We found that the A009 extracts limit lung cancer cell proliferation in a dose and time dependent manner. These effects were associated with the induction of apoptosis. A009 extracts were effective in inhibiting adhesion capabilities on a fibronectin layer accompanied with a reduction in their ability to generate invasive sprouts in a Matrigel layer. The production of chemokine CXCL12 and CXCR4 receptor were reduced by treatment with the extracts. Also, A009 interfered with the production of proangiogenic and pro-inflammatory VEGF, CXCL8, and CCL2 (as detected by FACS analysis) in the lung cell lines. A009 extracts were able to decrease STAT3 phosphorylation in lung cancer cells. Our results show that A009 extracts reduced activities related to tumor cell behavior in lung cancer cell lines, suggesting that they could have a potential cancer preventive role.

Published
2020

11. Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial

Author

Gibbons, KS, Schlapbach, LJ, Horton, SB, Long, DA, Beca, J, Erickson, S, Festa, M, d'Udekem, Y, Alphonso, N, Winlaw, D, Johnson, K, Delzoppo, C, van Loon, K, Gannon, B, Fooken, J, Blumenthal, A, Young, PJ, Butt, W, Schibler, A, Gibbons, KS, Schlapbach, LJ, Horton, SB, Long, DA, Beca, J, Erickson, S, Festa, M, d'Udekem, Y, Alphonso, N, Winlaw, D, Johnson, K, Delzoppo, C, van Loon, K, Gannon, B, Fooken, J, Blumenthal, A, Young, PJ, Butt, W, and Schibler, A

Abstract

Background: The NITric oxide during cardiopulmonary bypass (CPB) to improve Recovery in Infants with Congenital heart defects (NITRIC) trial, a 1320-patient, multicentre, randomised controlled trial, is aiming to improve survival free of ventilation after CPB by using nitric oxide delivered into the oxygenator of the CPB. Objective: To provide a statistical analysis plan before completion of patient recruitment and data monitoring. Final analyses for this study will adhere to this statistical analysis plan, which details all key pre-planned analyses. Stata scripts for analyses have been prepared alongside this statistical analysis plan. Methods: The statistical analysis plan was designed collaboratively by the chief investigators and trial statistician and builds on the previously published study protocol. All authors remain blinded to treatment allocation. Detail is provided on statistical analyses including cohort description, analysis of primary and secondary outcomes and adverse events. Statistical methods to compare outcomes are planned in detail to ensure methods are verifiable and reproducible. Results: The statistical analysis plan developed provides the trial outline, list of mock tables, and analysis scripts. The plan describes statistical analyses on cohort and baseline description, primary and secondary outcome analyses, process of care measures, physiological descriptors, and safety and adverse event reporting. We define the pre-specified subgroup analyses and the respective statistical tests used to compare subgroups. Conclusion: The statistical analysis plan for the NITRIC trial establishes detailed pre-planned analyses alongside Stata scripts to analyse the largest trial in the field of neonatal and paediatric heart surgery. The plan ensures standards for trial analysis validity aiming to minimise bias of analyses.

Published
2021

12. Resuscitation in Paediatric Sepsis Using Metabolic Resuscitation-A Randomized Controlled Pilot Study in the Paediatric Intensive Care Unit (RESPOND PICU): Study Protocol and Analysis Plan

Author

Schlapbach, LJ, Gibbons, K, Ridolfi, R, Harley, A, Cree, M, Long, D, Buckley, D, Erickson, S, Festa, M, George, S, King, M, Singh, P, Raman, S, Bellomo, R, Schlapbach, LJ, Gibbons, K, Ridolfi, R, Harley, A, Cree, M, Long, D, Buckley, D, Erickson, S, Festa, M, George, S, King, M, Singh, P, Raman, S, and Bellomo, R

Abstract

Introduction: Septic shock remains amongst the leading causes of childhood mortality. Therapeutic options to support children with septic shock refractory to initial resuscitation with fluids and inotropes are limited. Recently, the combination of intravenous hydrocortisone with high dose ascorbic acid and thiamine (HAT therapy), postulated to reduce sepsis-related organ dysfunction, has been proposed as a safe approach with potential for mortality benefit, but randomized trials in paediatric patients are lacking. We hypothesize that protocolised early use of HAT therapy ("metabolic resuscitation") in children with septic shock is feasible and will lead to earlier resolution of organ dysfunction. Here, we describe the protocol of the Resuscitation in Paediatric Sepsis Using Metabolic Resuscitation-A Randomized Controlled Pilot Study in the Paediatric Intensive Care Unit (RESPOND PICU). Methods and Analysis: The RESPOND PICU study is an open label randomized-controlled, two-sided multicentre pilot study conducted in paediatric intensive care units (PICUs) in Australia and New Zealand. Sixty children aged between 28 days and 18 years treated with inotropes for presumed septic shock will be randomized in a 1:1 ratio to either metabolic resuscitation (1 mg/kg hydrocortisone q6h, 30 mg/kg ascorbic acid q6h, 4 mg/kg thiamine q12h) or standard septic shock management. Main outcomes include feasibility of the study protocol and survival free of organ dysfunction censored at 28 days. The study cohort will be followed up at 28-days and 6-months post enrolment to assess neurodevelopment, quality of life and functional status. Biobanking will allow ancillary studies on sepsis biomarkers. Ethics and Dissemination: The study received ethical clearance from Children's Health Queensland Human Research Ethics Committee (HREC/18/QCHQ/49168) and commenced enrolment on June 12th, 2019. The primary study findings will be submitted for publication in a peer-reviewed journal. Trial Regist

Published
2021

13. Enteral versus intravenous approach for the sedation of critically ill patients: A randomized and controlled trial 11 Medical and Health Sciences 1103 Clinical Sciences

Author

Mistraletti, G, Umbrello, M, Salini, S, Cadringher, P, Formenti, P, Chiumello, D, Villa, C, Russo, R, Francesconi, S, Valdambrini, F, Bellani, G, Palo, A, Riccardi, F, Ferretti, E, Festa, M, Gado, A, Taverna, M, Pinna, C, Barbiero, A, Ferrari, P, Iapichino, G, Spanu, P, Anania, S, Andrighi, E, Di Carlo, A, Martinetti, F, Barello, S, Noto, A, Capello, G, Sabatelli, B, Brenna, G, Astori, M, Placido, P, Gattinoni, L, Protti, A, Pagan, F, Berto, V, Roselli, P, Ronzoni, G, Beck, E, Gaiotto, M, Radrizzani, D, Ferla, L, Giudici, R, Merlini, L, Pesenti, A, La Bruna, A, Rezoagli, E, Lucchini, A, Braschi, A, Niebel, T, Selvini, M, Cortesi, S, Quaini, A, Iotti, G, Contri, E, Sacchi, A, Livigni, S, Naretto, G, Deprado, A, Venturi degli Espositi, V, Caironi, P, Radeschi, G, Odetto, L, Ferrero, D, Cognolato, S, Penso, R, Vacchelli, R, Cardellino, S, Bosco, E, Bresciani, A, Pozzo, I, Alessio, A, Clarindo Rodrigues, V, Biase, E, Vivaldi, N, Nava, A, Rambaldi, M, Ponzetta, F, Bavutti, L, Palacios, B, Bergonzini, G, Mistraletti, G, Umbrello, M, Salini, S, Cadringher, P, Formenti, P, Chiumello, D, Villa, C, Russo, R, Francesconi, S, Valdambrini, F, Bellani, G, Palo, A, Riccardi, F, Ferretti, E, Festa, M, Gado, A, Taverna, M, Pinna, C, Barbiero, A, Ferrari, P, Iapichino, G, Spanu, P, Anania, S, Andrighi, E, Di Carlo, A, Martinetti, F, Barello, S, Noto, A, Capello, G, Sabatelli, B, Brenna, G, Astori, M, Placido, P, Gattinoni, L, Protti, A, Pagan, F, Berto, V, Roselli, P, Ronzoni, G, Beck, E, Gaiotto, M, Radrizzani, D, Ferla, L, Giudici, R, Merlini, L, Pesenti, A, La Bruna, A, Rezoagli, E, Lucchini, A, Braschi, A, Niebel, T, Selvini, M, Cortesi, S, Quaini, A, Iotti, G, Contri, E, Sacchi, A, Livigni, S, Naretto, G, Deprado, A, Venturi degli Espositi, V, Caironi, P, Radeschi, G, Odetto, L, Ferrero, D, Cognolato, S, Penso, R, Vacchelli, R, Cardellino, S, Bosco, E, Bresciani, A, Pozzo, I, Alessio, A, Clarindo Rodrigues, V, Biase, E, Vivaldi, N, Nava, A, Rambaldi, M, Ponzetta, F, Bavutti, L, Palacios, B, and Bergonzini, G

Subjects
Male, Simplified Acute Physiology Score, Patient care planning, Intensive Care Unit, Hypnotics and Sedative, Middle Aged, Enteral Nutrition, Nursing education research, Hydroxyzine, Central Nervous System Depressant, Critical Illne, Anesthesia, Female, Single-Blind Method, Poisson Distribution, Antipruritic, Deep Sedation, MED/41 - ANESTESIOLOGIA, Melatonin, Aged, Human
Abstract

Background: ICU patients must be kept conscious, calm, and cooperative even during the critical phases of illness. Enteral administration of sedative drugs might avoid over sedation, and would be as adequate as intravenous administration in patients who are awake, with fewer side effects and lower costs. This study compares two sedation strategies, for early achievement and maintenance of the target light sedation. Methods: This was a multicenter, single-blind, randomized and controlled trial carried out in 12 Italian ICUs, involving patients with expected mechanical ventilation duration > 72 h at ICU admission and predicted mortality > 12% (Simplified Acute Physiology Score II > 32 points) during the first 24 h on ICU. Patients were randomly assigned to receive intravenous (midazolam, propofol) or enteral (hydroxyzine, lorazepam, and melatonin) sedation. The primary outcome was percentage of work shifts with the patient having an observed Richmond Agitation-Sedation Scale (RASS) = target RASS ±1. Secondary outcomes were feasibility, delirium-free and coma-free days, costs of drugs, length of ICU and hospital stay, and ICU, hospital, and one-year mortality. Results: There were 348 patients enrolled. There were no differences in the primary outcome: enteral 89.8% (74.1-100), intravenous 94.4% (78-100), p = 0.20. Enteral-treated patients had more protocol violations: n = 81 (46.6%) vs 7 (4.2%), p < 0.01; more self-extubations: n = 14 (8.1%) vs 4 (2.4%), p = 0.03; a lighter sedative target (RASS = 0): 93% (71-100) vs 83% (61-100), p < 0.01; and lower total drug costs: 2.39 (0.75-9.78) vs 4.15 (1.20-20.19) €/day with mechanical ventilation (p = 0.01). Conclusions: Although enteral sedation of critically ill patients is cheaper and permits a lighter sedation target, it is not superior to intravenous sedation for reaching the RASS target. Trial registration: ClinicalTrials.gov, NCT01360346. Registered on 25 March 2011.

Published
2019

18. A comparison of three scoring systems for mortality risk among retrieved intensive care patients. (Original Article)

Author

Tibby, S.M., Taylor, D., Festa, M., Hanna, S., Hatherill, M., Jones, G., Habibi, P., Durward, A., and Murdoch, I.A.

Subjects
Mortality -- United Kingdom, Intensive care units -- Management, Critically ill children -- Care and treatment, Family and marriage, Health, Company business management, Management, Care and treatment
Abstract

Aims: To assess the impact of two paediatric intensive care unit retrieval teams on the performance of three mortality risk scoring systems: pre-ICU PRISM, PIM, and PRISM II. Methods: A [...]

Published
2002

22. Enteral versus intravenous approach for the sedation of critically ill patients: A randomized and controlled trial 11 Medical and Health Sciences 1103 Clinical Sciences

Author

Mistraletti, G., Umbrello, M., Salini, Sara, Cadringher, P., Formenti, P., Chiumello, D., Villa, C., Russo, R., Francesconi, S., Valdambrini, F., Bellani, G., Palo, A., Riccardi, F., Ferretti, E., Festa, M., Gado, A. M., Taverna, M., Pinna, C., Barbiero, A., Ferrari, P. A., Iapichino, G., Morabito, A., Langer, M., Valenza, F., Malacrida, R., Rambaldi, M., Spanu, P., Anania, S., Andrighi, E., Di Carlo, A., Martinetti, F., Barello, Serena, Noto, A., Capello, G., Sabatelli, B., Brenna, G., Astori, M., Placido, P., Gattinoni, L., Protti, A., Pagan, F., Berto, V., Roselli, P., Ronzoni, G., Beck, E., Gaiotto, M., Radrizzani, D., Ferla, L., Giudici, R., Merlini, L., Pesenti, A., La Bruna, A., Rezoagli, E., Lucchini, A., Braschi, A., Niebel, T., Selvini, M., Cortesi, S., Quaini, A., Iotti, G., Contri, E., Sacchi, A., Livigni, S., Naretto, G., Deprado, A., Venturi Degli Esposti, V., Caironi, P., Radeschi, G., Odetto, L., Ferrero, D., Cognolato, S., Penso, R., Vacchelli, R., Cardellino, S., Bosco, E., Bresciani, A., Pozzo, I., Alessio, A., Clarindo Rodrigues, V., Biase, E., Vivaldi, N., Nava, A., Ponzetta, F., Bavutti, L., Martina, P., Palacios, B., and Bergonzini, G.

Subjects
Male, Simplified Acute Physiology Score, Patient care planning, Critical Illness, Central Nervous System Depressants, Hypnotics and sedatives, Antipruritics, Middle Aged, Hydroxyzine, Melatonin, Nursing education research, Aged, Anesthesia, Deep Sedation, Enteral Nutrition, Female, Humans, Hypnotics and Sedatives, Intensive Care Units, Poisson Distribution, Single-Blind Method, Settore MED/41 - ANESTESIOLOGIA
Published
2019

23. Strategies to control antibiotic resistance: Results from a survey in Italian children's hospitals

Author

degli Atti, M. L. C., D'Amore, C., Gagliotti, C., Zotti, C., Ricchizzi, E., Moro, M. L., Raponi, M., degli Atti, M. C., Serino, L., Gargiullo, L., De Luca, M., Guareschi, G., Migliore, E., Dal Maso, P., Savelli, A., Barbacci, P., Biermann, K. P., Spiazzi, R., Amoruso, D., Festa, M. G., Strabla, D., Bevilacqua, P., and Signorini, L.

Subjects
Cross Infection, Infection Control, Antibiotic resistance, Bacterial Infections, Antimicrobial stewardship, Hospitals, Pediatric, Anti-Bacterial Agents, Tertiary Care Centers, Cross-Sectional Studies, Italy, Hospital-acquired-infections, Drug Resistance, Multiple, Bacterial, Health Care Surveys, Humans, Practice Patterns, Physicians', Children, Survey
Abstract

Antimicrobial stewardship programs and comprehensive infection control programs represent the main strategies to limit the emergence and transmission of multi-drug resistant bacteria in hospital settings. The purpose of this study was to describe strategies implemented in Italian children's hospitals for controlling antibiotic resistance.Cross sectional multicenter study.Four tertiary care Italian children's hospitals were invited to participate in a survey aimed at collecting information on activities implemented as of December 2015 using a self-administered online questionnaire. The questionnaire was divided in three sections focalizing on: i) policies for prevention and control of hospital-acquired infection, ii) prevention and control of multi-drug resistant bacteria, and iii) antibiotic prescribing policies and Antimicrobial stewardship programs. Questionnaires were compiled between May and July 2016.All hospitals had multidisciplinary infection control committee, procedures on hand hygiene, isolation measures, disinfection/sterilization, waste disposal and prevention on infections associated to invasive procedures. All sites screened patients for multi-drug resistant bacteria colonization in selected units, and adopted contact precautions for colonized patients. Screening during hospitalization, or in case of infections in the same ward were not universally implemented. All hospitals had policies on surgical prophylaxis, while policies on medical prophylaxis and treatment of bacterial infections varied among sites. Two sites recommended to review the appropriateness of antibiotic prescribing after 48-72 hours and one recommended de-escalation therapy.This study highlighted several areas of improvement, such as actions for screening patients in case of occurrence of multi-drug resistant bacteria, antimicrobial stewardship programs and implementation of policies targeting antibiotic prescriptions for therapeutic purposes and medical prophylaxis.

Published
2019

25. Transnasal Humidified Rapid Insufflation Ventilatory Exchange in children requiring emergent intubation (Kids THRIVE): a protocol for a randomised controlled trial

Author

George, S, Humphreys, S, Williams, T, Gelbart, B, Chavan, A, Rasmussen, K, Ganeshalingham, A, Erickson, S, Ganu, SS, Singhal, N, Foster, K, Gannon, B, Gibbons, K, Schlapbach, LJ, Festa, M, Dalziel, S, Schibler, A, Sargent, P, Bell, C, George, S, Humphreys, S, Williams, T, Gelbart, B, Chavan, A, Rasmussen, K, Ganeshalingham, A, Erickson, S, Ganu, SS, Singhal, N, Foster, K, Gannon, B, Gibbons, K, Schlapbach, LJ, Festa, M, Dalziel, S, Schibler, A, Sargent, P, and Bell, C

Abstract

INTRODUCTION: Emergency intubation of children with abnormal respiratory or cardiac physiology is a high-risk procedure and associated with a high incidence of adverse events including hypoxemia. Successful emergency intubation is dependent on inter-related patient and operator factors. Preoxygenation has been used to maximise oxygen reserves in the patient and to prolong the safe apnoeic time during the intubation phase. Transnasal Humidified Rapid Insufflation Ventilatory Exchange (THRIVE) prolongs the safe apnoeic window for a safe intubation during elective intubation. We designed a clinical trial to test the hypothesis that THRIVE reduces the frequency of adverse and hypoxemic events during emergency intubation in children and to test the hypothesis that this treatment is cost-effective compared with standard care. METHODS AND ANALYSIS: The Kids THRIVE trial is a multicentre randomised controlled trial performed in participating emergency departments and paediatric intensive care units. 960 infants and children aged 0-16 years requiring emergency intubation for all reasons will be enrolled and allocated to THRIVE or control in a 1:1 allocation with stratification by site, age (<1, 1-7 and >7 years) and operator (junior and senior). Children allocated to THRIVE will receive weight appropriate transnasal flow rates with 100% oxygen, whereas children in the control arm will not receive any transnasal oxygen insufflation. The primary outcomes are defined as follows: (1) hypoxemic event during the intubation phase defined as SpO2 <90% (patient-dependent variable) and (2) first intubation attempt success without hypoxemia (operator-dependent variable). Analyses will be conducted on an intention-to-treat basis. ETHICS AND DISSEMINATION: Ethics approval for the protocol and consent process has been obtained (HREC/16/QRCH/81). The trial has been actively recruiting since May 2017. The study findings will be submitted for publication in a peer-reviewed journal. TRIAL REG

Published
2019

26. Defining benefit threshold for extracorporeal membrane oxygenation in children with sepsis-a binational multicenter cohort study

Author

Schlapbach, LJ, Chilettr, R, Straney, L, Festa, M, Alexander, D, Butt, W, MacLaren, G, Ganeshalingam, A, Sherring, C, Erickson, S, Barr, S, Schibler, A, Long, D, Schlapbach, L, Alexander, J, George, S, Williams, G, Smith, V, Delzoppo, C, Millar, J, Gelbart, B, Oberender, F, Ganu, S, Letton, G, Egan, J, Harper, G, Schlapbach, LJ, Chilettr, R, Straney, L, Festa, M, Alexander, D, Butt, W, MacLaren, G, Ganeshalingam, A, Sherring, C, Erickson, S, Barr, S, Schibler, A, Long, D, Schlapbach, L, Alexander, J, George, S, Williams, G, Smith, V, Delzoppo, C, Millar, J, Gelbart, B, Oberender, F, Ganu, S, Letton, G, Egan, J, and Harper, G

Abstract

BACKGROUND: The surviving sepsis campaign recommends consideration for extracorporeal membrane oxygenation (ECMO) in refractory septic shock. We aimed to define the benefit threshold of ECMO in pediatric septic shock. METHODS: Retrospective binational multicenter cohort study of all ICUs contributing to the Australian and New Zealand Paediatric Intensive Care Registry. We included patients < 16 years admitted to ICU with sepsis and septic shock between 2002 and 2016. Sepsis-specific risk-adjusted models to establish ECMO benefit thresholds with mortality as the primary outcome were performed. Models were based on clinical variables available early after admission to ICU. Multivariate analyses were performed to identify predictors of survival in children treated with ECMO. RESULTS: Five thousand sixty-two children with sepsis and septic shock met eligibility criteria, of which 80 (1.6%) were treated with veno-arterial ECMO. A model based on 12 clinical variables predicted mortality with an AUROC of 0.879 (95% CI 0.864-0.895). The benefit threshold was calculated as 47.1% predicted risk of mortality. The observed mortality for children treated with ECMO below the threshold was 41.8% (23 deaths), compared to a predicted mortality of 30.0% as per the baseline model (16.5 deaths; standardized mortality rate 1.40, 95% CI 0.89-2.09). Among patients above the benefit threshold, the observed mortality was 52.0% (13 deaths) compared to 68.2% as per the baseline model (16.5 deaths; standardized mortality rate 0.61, 95% CI 0.39-0.92). Multivariable analyses identified lower lactate, the absence of cardiac arrest prior to ECMO, and the central cannulation (OR 0.31, 95% CI 0.10-0.98, p = 0.046) as significant predictors of survival for those treated with VA-ECMO. CONCLUSIONS: This binational study demonstrates that a rapidly available sepsis mortality prediction model can define thresholds for survival benefit in children with septic shock considered for ECMO. Survival on ECMO wa

Published
2019

27. Study protocol: NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC trial): a randomised controlled trial

Author

Schlapbach, LJ, Horton, SB, Long, DA, Beca, J, Erickson, S, Festa, M, d'Udekem, Y, Alphonso, N, Winlaw, D, Johnson, K, Delzoppo, C, van Loon, K, Gannon, B, Fooken, J, Blumenthal, A, Young, P, Jones, M, Butt, W, Schibler, A, Millar, J, Buckley, D, Evans, T, Sherring, C, Artrip, J, O'Shaughnessy, K, Fletcher, R, Byrne, S, Barr, S, Kelly, R, Andrews, D, Johnston, K, Zuzak, C, Anderson, B, van Belle-van Haaren, NJCW, van Wijk, B, Koomen, E, Schlapbach, LJ, Horton, SB, Long, DA, Beca, J, Erickson, S, Festa, M, d'Udekem, Y, Alphonso, N, Winlaw, D, Johnson, K, Delzoppo, C, van Loon, K, Gannon, B, Fooken, J, Blumenthal, A, Young, P, Jones, M, Butt, W, Schibler, A, Millar, J, Buckley, D, Evans, T, Sherring, C, Artrip, J, O'Shaughnessy, K, Fletcher, R, Byrne, S, Barr, S, Kelly, R, Andrews, D, Johnston, K, Zuzak, C, Anderson, B, van Belle-van Haaren, NJCW, van Wijk, B, and Koomen, E

Abstract

INTRODUCTION: Congenital heart disease (CHD) is a major cause of infant mortality. Many infants with CHD require corrective surgery with most operations requiring cardiopulmonary bypass (CPB). CPB triggers a systemic inflammatory response which is associated with low cardiac output syndrome (LCOS), postoperative morbidity and mortality. Delivery of nitric oxide (NO) into CPB circuits can provide myocardial protection and reduce bypass-induced inflammation, leading to less LCOS and improved recovery. We hypothesised that using NO during CPB increases ventilator-free days (VFD) (the number of days patients spend alive and free from invasive mechanical ventilation up until day 28) compared with standard care. Here, we describe the NITRIC trial protocol. METHODS AND ANALYSIS: The NITRIC trial is a randomised, double-blind, controlled, parallel-group, two-sided superiority trial to be conducted in six paediatric cardiac surgical centres. One thousand three-hundred and twenty infants <2 years of age undergoing cardiac surgery with CPB will be randomly assigned to NO at 20 ppm administered into the CPB oxygenator for the duration of CPB or standard care (no NO) in a 1:1 ratio with stratification by age (<6 and ≥6 weeks), single ventricle physiology (Y/N) and study centre. The primary outcome will be VFD to day 28. Secondary outcomes include a composite of LCOS, need for extracorporeal membrane oxygenation or death within 28 days of surgery; length of stay in intensive care and in hospital; and, healthcare costs. Analyses will be conducted on an intention-to-treat basis. Preplanned secondary analyses will investigate the impact of NO on host inflammatory profiles postsurgery. ETHICS AND DISSEMINATION: The study has ethical approval (HREC/17/QRCH/43, dated 26 April 2017), is registered in the Australian New Zealand Clinical Trials Registry (ACTRN12617000821392) and commenced recruitment in July 2017. The primary manuscript will be submitted for publication in a peer-reviewed

Published
2019

29. Fluid bolus therapy: A survey of practice among paediatric intensive care doctors in australia and New Zealand.

Author

Ganu S., Erickson S., Oberender F., Hoq M., Williams G., George S., Gelbart B., Schlapbach L., Festa M., Ganeshalingham A., Ganu S., Erickson S., Oberender F., Hoq M., Williams G., George S., Gelbart B., Schlapbach L., Festa M., and Ganeshalingham A.

Abstract

Aims & Objectives: Objective: Fluid bolus therapy (FBT) is a widely used intervention in paediatric critical illness. The aim of this study was to describe the attitudes and practices of paediatric intensive care doctors in Australia and New Zealand (ANZ) towards FBT. Method(s): We conducted an internet-based survey of paediatric intensive care specialists and junior medical staff in paediatric intensive care units with greater than 400 admissions annually between November 7th 2016 and November 30th 2016. Preferences for composition of FBT, markers of fluid responsiveness and preferences in specific disease states were sought. Result(s): There were 106/175(61%) respondents. 0.9% saline and 4% albumin are used frequently or almost always by 86% and 57% of respondents respectively. The preferred volume and duration were 10ml/kg in less than 10 minutes. Highest rated markers of fluid responsiveness were heart rate and blood pressure; rated as good or very good by 75% and 58% respectively. Central venous saturations and serum lactate were the highest rated biochemical markers. The most frequently expected magnitude of change for heart rate and blood pressure was 6-15% by 89% and 76% of respondents respectively. 0.9% saline was the preferred fluid for sepsis, trauma, traumatic brain injury and acute lung injury but not for post-op cardiac surgery. Conclusion(s): Paediatric intensive care doctors prefer 0.9% saline and 4% albumin for FBT. Heart rate and blood pressure are the most preferred markers to assess fluid responsiveness. Disease specific preferences for FBT exist.

Published
2018

30. Fluid bolus therapy in critically ill children: a survey of practice among paediatric intensive care doctors in Australia and New Zealand.

Author

Williams G., Oberender F., Hoq M., George S., Festa M., Gelbart B., Schlapbach L., Ganeshalingham A., Ganu S., Erickson S., Williams G., Oberender F., Hoq M., George S., Festa M., Gelbart B., Schlapbach L., Ganeshalingham A., Ganu S., and Erickson S.

Abstract

OBJECTIVE: Fluid bolus therapy (FBT) is a widely used intervention in paediatric critical illness. The aim of this study was to describe the attitudes and practices towards FBT of paediatric intensive care doctors in Australia and New Zealand. DESIGN: An internet-based survey of paediatric intensive care doctors in Australia and New Zealand between 7 and 30 November 2016. SETTING: Paediatric intensive care units with greater than 400 admissions annually. PARTICIPANTS: Paediatric intensive care specialists and junior medical staff. MAIN OUTCOME MEASURES: Preferences for FBT and markers of fluid responsiveness. RESULTS: There were 106/175 respondents (61%); 0.9% saline and 4% albumin are used frequently or almost always by 86% and 57% of respondents respectively. The preferred volume and duration were 10 mL/kg in less than 10 minutes. The highest rated markers of fluid responsiveness were heart rate and blood pressure - rated as "good" or "very good" by 75% and 58% of respondents respectively. Central venous saturations and serum lactate were the highest rated biochemical markers. The most frequently expected magnitude of change for heart rate and blood pressure was 6-15% by 89% and 76% of respondents respectively. The preferred fluid composition for sepsis, trauma, traumatic brain injury and acute lung injury was 0.9% saline, and 4% albumin for post-operative cardiac surgery. CONCLUSIONS: Paediatric intensive care doctors prefer 0.9% saline and 4% albumin for FBT. Heart rate and blood pressure are the most preferred markers to assess fluid responsiveness. Preferences for FBT in specific conditions exist.

Published
2018

31. Abstract P-008

Author

Gelbart, B., primary, Schlapbach, L., additional, Festa, M., additional, Ganeshalingham, A., additional, Ganu, S., additional, Erickson, S., additional, Oberender, F., additional, Hoq, M., additional, Williams, G., additional, and George, S., additional

Published
2018
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32. Abstract P-430

Author

Harper, G., primary, Newton, K., additional, Schell, D., additional, Brad, C., additional, Festa, M., additional, Harper, D., additional, and Wood, R., additional

Published
2018
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33. Abstract PD-039

Author

Larson, C., primary, Crowe, L., additional, Cross, J., additional, Festa, M., additional, Ganu, S., additional, Jackson, H., additional, Miles, F., additional, Swil, K., additional, Dryden-Palmer, K., additional, Parshuram, C., additional, and Millar, J., additional

Published
2018
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34. Vaginoscopic versus traditional office hysteroscopy

Author

Guida, M, Sorrentino, F, Sparice, S, Bramante, S, Canzaniello, D, Coppola, C, Festa, M, DI SPIEZIO SARDO, ATTILIO, NAPPI, CARMINE, Guida M, Di Spiezio Sardo A, Sorrentino F, Sparice S, Bramante S, Canzaniello, Coppola C, Festa M, Nappi C., Guida, M, DI SPIEZIO SARDO, Attilio, Sorrentino, F, Sparice, S, Bramante, S, Canzaniello, D, Coppola, C, Festa, M, and Nappi, Carmine

Published
2007

35. Outpatient hysteroscopiy emptying of a submucosal uterine cystic lesion

Author

DI SPIEZIO SARDO, ATTILIO, BIFULCO, GIUSEPPE, Guida, M, Frangini, S, Festa, M, Sosa Fernandez, Lm, Borriello, M, Nappi, C., Di Spiezio Sardo A, Guida M, Bifulco G, Frangini S, Festa M, Sosa Fernandez LM, Borriello M, Nappi C., DI SPIEZIO SARDO, Attilio, Guida, M, Bifulco, Giuseppe, Frangini, S, Festa, M, Sosa Fernandez, Lm, Borriello, M, and Nappi, C.

Published
2007

36. Synthesis and cytotoxic activity of new β-carboline derivatives

Author

Peduto, A, More, V, de Caprariis, P, Festa, M, Capasso, A, Piacente, S, De Martino, L, De Feo, V, FILOSA, Rosanna, Peduto, A, More, V, de Caprariis, P, Festa, M, Capasso, A, Piacente, S, De Martino, L, De Feo, V, and Filosa, Rosanna

Subjects
Antineoplastic Agent, Carboline, Cell Line, Tumor, Humans, Drug Screening Assays, Antitumor
Abstract

On the basis of harmine and 1-methoxy-canthin-6-one chemical structures, a series of novel 1,4-disubstituted and 1,4,9-trisubstituted β-carbolines and tetracyclic derivatives were designed and synthesized. Cytotoxic activities of these compounds in vitro were investigated in a human tumor cell line panel. Almost all compounds demonstrated interesting cytotoxic activities in particular against prostate cancer cells PC-3 with IC50 in the low micromolar range. Compound X was found to be the most potent one with IC50 value of 8.0 µM; this suggests further studies with models of prostate cancer.

Published
2011

37. Maxillary and mandibular base size in ancient skulls and of modern humans from Opi, Abruzzi, Italy: a cross-sectional study

Author

Felice FESTA, Capasso, L., D Anastasio, R., Anastasi, G., Festa, M., Caputi, S., Tecco, S., Festa, F, Capasso, L, D'Anastasio, R, Anastasi, G, Festa, M, Caputi, S, and Tecco, Simona

Subjects
Mandibular bone, Adult, Male, skull, Adolescent, growth, Cephalometry, Paleontology, Mandible, Middle Aged, Young Adult, Cross-Sectional Studies, Italy, Maxilla, Humans, Female, History, Ancient
Abstract

The size and shape of the jaws are related to occlusion and masticatory muscle function. Consequently, teeth and muscles are considered the functional matrix for the two jaws. Existing studies did not focus on the relationship between maxillary and mandibular base but on just their absolute dimensions. As the relationship between the two is of interest to orthodontists, the aim of this study was to calculate the maxillary-mandibular ratio (m-m ratio) in individuals from Central Italy and to compare it to that of ancient skulls from the same geographic area.Forty individuals from Opi, a small, isolated mountain village in Central Italy, and 40 ancient skulls from the same region were the sample of this study. The lengths of the maxillary and mandibular base were assessed on lateral cephalograms, the m-m ratio was calculated, and the measurements between the groups were compared.Due to a significantly shorter maxillary base in the modern human sample, the m-m ratio was significantly lower in these subjects.This finding supports the hypothesis that growth of the skull is strongly modulated by the functional matrix, within which a morphologic unit develops.

Published
2010

42. Práticas de gestão e cultura intraempreendedora:um estudo sobre as práticas de gestão que contribuem para um cultura organizacional capaz de gerar intraempreendimentos

Author

Festa, M. P. and Vasconcelos, I. F. F. G.

Subjects
Intraempreendedorismo, Cultura organizacional, Administração
Abstract

A pesquisa teve como objetivo identificar quais as práticas de gestão que contribuem para uma cultura organizacional capaz de gerar ações empreendedoras eficientes. O método utilizado foi o de estudo de caso, em empresa do setor de tecnologia da informação e serviços de internet, reconhecidamente inovadora, com operação no Brasil, neste trabalho denominada como Empresa G. A questão de pesquisa respondida foi: De acordo com a visão dos colaboradores da Empresa G, quais as práticas de gestão que contribuem para uma cultura organizacional capaz de gerar intraempreendimentos, proporcionando assim, os resultados almejados pela empresa em termos de criação e lançamento de novos produtos, criação e/ou adesão de novos processos, criação e/ou adesão de novos modelos de gestão, ou ainda, o ingresso em novos negócios? A coleta de dados estruturou-se por meio de análise documental de fontes primária e secundárias; entrevistas semiestruturadas; e realização de observações direta e participante. As práticas de gestão encontradas foram classificadas em dez categorias (características), são elas: sistema de recompensas, incentivos e reconhecimento; tolerância a riscos, erros e/ou fracassos; patrocínio/apoio de níveis hierárquicos superiores; atuação em equipes multifuncionais; disponibilidade de recursos (tempo e dinheiro); liberdade e autonomia; estrutura organizacional com baixo territorialismo; compartilhamento de informações e objetivos organizacionais; foco no longo prazo; e propensão à mudança. Os resultados da pesquisa evidenciam que determinadas práticas de gestão possuem a capacidade de contribuir para uma cultura organizacional capaz de gerar intraempreendimentos, proporcionando assim, os resultados pretendidos pela companhia em termos de inovação. The research aimed to identify management practices that contribute to an organizational culture capable to generate efficient entrepreneurial actions. The utilized method was case study, in a company of the information technology sector and internet services, admittedly innovative, with operations in Brazil, in this paper referred as "Company G". The research question answered was: According to the Company G employees point of view, which management practices contribute to an organizational culture capable to generate internal enterprises, providing the desired results for the company, in terms of creation and release of new products, creation and/or accession of new processes, creation and/or accession of new business models, or also, the entry into new business? The data collection was structured by primary and secondary documentary analysis sources; semi-structured interviews; and direct and participant observations. The found management practices were classified into ten categories (features), they are: rewards, incentives and recognition systems; tolerance to risks, errors and/or failures; sponsorship/support of higher hierarchical levels; performance in cross-functional teams; resources availability (time and money); freedom and autonomy; organizational structure with poor "territorialism"; sharing of information and organizational goals; focus in the future; and propensity to change. The survey results show that certain management practices have the capability to contribute to an organizational culture capable to generate internal enterprises, providing the desired results for the company in terms of innovation.

Published
2013

43. Protesi valvolari

Author

CASALE D, FESTA M, RENZULLI A, CERASUOLO F, ONORATI F, MARESCA L., DE FEO, Marisa, COTRUFO M, RENZULLI A, DE FEO M, Casale, D, Festa, M, Renzulli, A, DE FEO, Marisa, Cerasuolo, F, Onorati, F, and Maresca, L.

Published
2002

45. The Arabidopsis central vacuole as an expression system for intracellular transporters: functional characterization of the Cl-/H+ exchanger CLC-7

Author

Costa A, Gutla PVK, Boccaccio A, Scholz-Starke J, Festa M, Basso B, Zanardi I, Pusch M, Lo Schiavo F, Gambale F, and Carpaneto A

Subjects
CHLORIDE CHANNELS, RELEASE CHANNEL, LYSOSOMES, PLANT VACUOLES
Abstract

Functional characterization of intracellular transporters is hampered by the inaccessibility of animal endomembranes to standard electrophysiological techniques. Here, we used Arabidopsis mesophyll protoplasts as a novel heterologous expression system for the lysosomal chloride-proton exchanger CLC-7 from rat. Following transient expression of a rCLC-7:EGFP construct in isolated protoplasts, the fusion protein efficiently targeted to the membrane of the large central vacuole, the lytic compartment of plant cells. Membrane currents recorded from EGFP-positive vacuoles were almost voltage independent and showed time-dependent activation at elevated positive membrane potentials as a hallmark. The shift in the reversal potential of the current induced by a decrease of cytosolic pH was compatible with a 2Cl-/1H+ exchange stoichiometry. Mutating the so-called gating glutamate into alanine (E245A) uncoupled chloride fluxes from the movement of protons, transforming the transporter into a chloride channel-like protein. Importantly, CLC-7 transport activity in the vacuolar expression system was recorded in the absence of the auxiliary subunit Ostm1, differently to recent data obtained in Xenopus oocytes using a CLC-7 mutant with partial plasma membrane expression. We also show that plasma membrane-targeted CLC-7E245A is non-functional in Xenopus oocytes when expressed without Ostm1. In summary, our data suggest the existence of an alternative CLC-7 operating mode, which is active when the protein is not in complex with Ostm1. The vacuolar expression system has the potential to become a valuable tool for functional studies on intracellular ion channels and transporters from animal cells.

Published
2012

49. Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study

Author

Keth, Th, Azoulay, E, Echeverria, Pm, Vincent, Jl, Collaboratorsmargarit, A, Valentini, R, Alan Javier, Z, Bevilacqua, C, Curone, M, Rabuffetti, R, Comignani, P, Torres Boden, M, Chertcoff, F, Cardonatti, G, Adén, F, Marcos, L, Dónofrio, M, Fernández, R, Lamberghini, R, Balasini, S, Teves, J, Las Heras, M, Sinner, J, Ceraso, D, Curcio, D, Aguilar, L, Weller, C, Cardonnet, L, Santa Cruz, R, Manrique, E, Bernardez, D, Iolster, T, Chiappero, G, Ramos, P, Vergara, J, Moine, I, Ilutovich, S, Jannello, G, Waschbusch, M, Rios Picaza, G, Raimondi, A, Miriam, M, Lovesio, C, Caridi, M, Leong, T, Orford, N, Reece, G, Ernest, D, Hawker, F, Tan, J, Giannellis, C, Ihle, B, Bersten, A, Mcinnes, J, Tallott, M, Mcfadyen, B, Vibert, J, Parr, M, Tran, K, Sutton, J, Webb, S, Groves, N, Cole, L, Long, D, Bass, F, Erickson, S, Lipman, J, Delzoppo, C, Thomas, J, Dobb, G, Daley, M, Roberts, B, Santamaria, J, Young, J, Festa, M, Holland, R, Mullany, D, Williams, P, Corkeron, M, Gales, M, Banerjee, A, Yung, M, Mutz, N, Hiesmayr, M, Faybik, P, Fitzgerald, R, Firlinger, F, Zasmeta, G, Zink, M, Sieber, W, Hildegard, J, Bakondy, R, Schlieber, J, Filzwieser, G, Beer, R, Joannidis, M, Schuster, R, Scherzer, W, Smolle, K, Fitzal, S, Manzoor, R, Brunain, J, D'Hondt, A, Huylenbroeck, G, Van der Schueren, M, 't Kindt, H, Slock, E, Rijckaert, D, Raemaekers, J, Bourgeois, M, Van Cotthem, I, Nackaerts, G, Gusu, D, Gadisseux, P, Vancollie, O, Lignian, H, Michel, P, Fraipont, V, Vander Stappen, M, Forêt, F, De Bels, D, Devriendt, J, Massaut, J, Biston, P, Roman, A, Lambermont, B, De Meulder, A, Frederic, V, Sottiaux, T, Ruyffelaere, P, Collin, V, Anane, S, Kleiren, P, Simon, M, Machayekhi, S, Frans, E, Leroy, G, Berghmans, T, Joseph, R, Eerens, J, Laterre, P, Lagrou, B, Rutsaert, R, Pisarek, W, Dive, A, De Waele, J, Spapen, H, Damas, P, Malbrain, M, Hidalgo, J, Baptista, M, Salgado, D, Braga, M, Avila, C, Westphal, G, Caser, E, Alves, A, Friedman, G, Luz, M, Assuncao, M, Reis, H, Gomes, A, Silva, U, Nogueira Fh, W, El Dash, S, Valiatti, J, Barbosa, A, Coelho, C, Knibel, M, Minelli, C, Caovilla, J, Teixeira, G, Hovnanian, A, Rea Neto, A, Lobo, S, Lugarinho, M, Souza, P, Ferreira, D, Duarte, P, Oliveira, M, Marques, J, Machado, R, Rehder, P, Mataloun, S, Grilo, M, Quesado, P, Moock, M, Ferreira, F, Teles, J, Silva, E, Morais, A, Bruzzi de Carvalho, F, Wanderley, M, Velasco, M, Brandão da Silva, N, Feijó, J, Souza Dantas, V, Costa Filho, R, Japiassú, A, Villela, D, Santos, C, Passos, R, Alheira Rocha, R, Silva, R, Houly, J, Aldrighi, J, Hatum, R, Suparregui Dias, F, Ferreira, L, Ferro, L, Gomez, J, Fleury, R, David, C, Resener, T, Mendes, C, Germano, A, De Marco, F, Lage, S, Salluh, J, Torelly, A, Sad, R, Oliveira, G, Lima, R, Paranhos, J, Rocha, M, Bitencourt, W, Grion, C, Forte, D, Guimarães, H, Piras, C, Stephanova, L, Lyubenov, L, Tsarianski, G, Dimov, G, Green, R, Levasseur, J, Ward, R, Lesur, O, Poirier, G, Wax, R, Wood, G, Cook, D, Marshall, J, Herridge, M, Ferguson, N, Espinoza, M, Valdés jimenez, S, Bruhn, A, Micolich, J, Fricke, G, Galvez, S, Escamilla Leon, I, Zhan, Q, Xu, Y, Zhao, Y, Zhang, L, Qin, T, Du, B, Li, M, Wang, X, Jing, Y, Zhang, Z, Xianyao, W, Li, F, Congshan, Y, Rebolledo, C, Diaz, D, Murillo Arboleda, R, Arias Antun, A, Montenegro, G, Granados, M, Dueñas, C, Perez, N, Libreros Duque, G, Coral, M, Ortiz, G, Rodriguez, D, Barsic, B, Cubrilo Turek, M, Gornik, I, Grljusic, M, Caballero lopez, A, Iraola Ferrer, M, Pavlik, P, Manak, J, Radej, J, Belohlavek, J, Sevcik, P, Blahut, L, Tyl, D, Steinbach, J, Herold, I, Zykova, I, Prchal, D, Bartosik, T, Kolarova, M, Hájek, R, Kohoutová, J, Marek, O, Hon, P, Chytra, I, Betsch, H, Fogh, B, Espersen, K, Jacobsen, K, Berezowicz, P, Andrade, C, Guerrero, F, Salgado, E, Barahona, D, Del Pozo Sanchez, H, Jibaja, M, Alansary, A, Reintam, A, Starkopf, J, Harjola, V, Tual, L, Leone, M, Serge, M, Leroy, O, Mallet, L, Marc, B, Dormoy, D, Pascal, H, Tronchon, L, Garrigues, B, Santré, C, Dupont, H, Duranteau, J, Leon, A, Henry, L, Canevet, C, Dube, L, Julien, H, Nadia, A, Francois, B, Gérard, J, Freysz, M, Remy, G, Blanloeil, Y, Squara, P, Korach, Jm, Durand, M, Gabriel, C, Eric, P, Jacobs, F, Bronchard, R, Kipnis, E, Moussa, M, Launoy, A, Guérin, C, Vanhems, P, Wynckel, A, Clair, B, Fulgencio, J, Gottwalles, Y, Krummel, T, Lepape, A, Lesieur, O, Payen, D, Hérvé, O, Farkas, J, Cougot, P, Mallédant, Y, Joannes Boyau, O, Standl, T, Sierig, U, Geiseler, J, Hopf, H, Conrad Opel, E, Hermann, C, Ventzke, M, Henneberg, T, Esposito, F, Loeser, H, Spies, C, Zuckermann Becker, H, Voegeler, S, Scherer, R, Pauer, A, Kljucar, S, Delfs, K, Blank, E, Busch, J, Wendt, K, Lessmann, J, Bach, F, Sakr, Y, Berlet, T, Kernchen, A, Quintel, M, Holst, D, Kilger, E, Holubarsch, T, Raufhake, C, Stolt, C, Lubasch, A, Meier Hellmann, A, Woebker, G, Scharnofske, C, Breyer, M, Risch, T, Manhold, C, Goethe, Jw, Meininger, D, Greive, C, Rau, J, Seibel, A, Henn beilharz, A, Wolbert, R, Scherke, T, Martin, J, Rudolph, M, Gleissner, J, Wolf, M, Schleibach, F, Jaschinski, U, Lunkeit, A, Welte, M, Bingold, T, Kogelmann, K, Fischer, F, Fischer, B, Schmid, M, Klein, M, Bechtold, A, Bodmann, K, Klasen, J, Meyrl, H, Goetz, J, Geldner, G, Helmes, T, Jensen, N, Eickmeyer, H, Lengfelder, W, Langenstein, B, Bogdanski, R, Jelen Esselborn, S, Umgelter, A, Dörr, F, Lüttje, K, Heinemeyer, D, Uhl, M, Schirle, P, Benad, H, Glaser, M, Panzer, W, Huettemann, E, Stierwaldt, R, Schappacher, M, Müller, E, Stadlmeyer, W, Fantini, M, Dummer, B, Thörner, M, Jost, V, Loerbroks, T, Glück, T, Zimmermann, R, Clement, R, Hering, R, Klinger, T, Mehl, J, Polozek, H, Rothhammer, A, Seidler, R, Lorenz, P, Mueritz, W, Lutze, M, Euler, M, Heintz, M, Winkler, M, Angstwurm, M, Krohe, K, Treu, T, Steiner, T, Locher, S, Walz, A, Zahn, P, Brandt, W, Marks, M, Henning, F, Janssens, U, Luethgens, M, Theelen, W, Sydow, M, Weber, M, Meiser, A, Deutschmann, C, Buttner, C, Jokiel, M, Bozzetti, C, Jürgen, B, Fiedler, F, Wresch, K, Kremer, A, Bleier, H, Rueckert, M, Ditter, H, Peckelsen, C, Friederich, P, Weber, K, Krueger, W, Lowack, R, Michalsen, A, Ragaller, M, Groeschel, A, Friedrich, T, Hinz, M, Christel, A, Hartwig, T, Kaisers, U, Schmitt, D, Vögeler, S, Weiss, M, Reiter, K, Schwab, T, Trieschmann, U, Kindgen milles, D, Engel, J, Sedemund adib, B, Lauterbach, M, Max, M, Volkert, T, Waydhas, C, Hien, S, Briegel, J, Guralnik, V, Zoremba, N, Riessen, R, Müllges, W, Nierhaus, A, Strauss, R, Utzolino, S, Thul, J, Abel, P, Gründling, M, Kessler, W, Scheuren, K, Vagts, D, Rensing, H, Schoch, B, Kopp, K, Gerlach, H, Corea, M, Uhrig, A, Schroeder, S, Jordan, F, Huber, T, Bittinger, M, Sofianos, E, Armaganidis, A, Routsi, C, Bitzani, M, Chalkiadaki, A, Michalopoulos, A, Mouloudi, E, Ioannidou, E, Myrianthefs, P, Koulenti, D, Karampela, I, Kyriazopoulos, G, Mandragos, K, Clouva molyvdas, P, Moraiti, A, Pneumatikos, I, Filos, K, Zakynthinos, E, Kotanidou, A, Vakalos, A, Cheng, A, Buckley, T, Gomersall, C, Kiss, K, Tamási, P, Sarkany, A, Csomos, A, Zöllei, É, Todi, S, Udwadia, F, Shah, R, Amin, P, Samavedam, S, Mathai, A, Patil, M, Jog, S, Gurjar, M, Vats, M, Varma, A, Gopal, P, Kapadia, F, Chawla, R, Iyer, S, Sahu, S, Bakshi, C, Ambike, D, Govil, D, Karipparambath, V, Chacko, J, Sathe, P, Rungta, N, Jani, C, Bhome, A, Prayag, S, Ray, S, Rajagopalan, R, Divatia, J, Da costa, R, Shyam Sunder, T, Wibowo, P, Maskoen, T, Sugiman, T, Nowruzinia, S, Lotfi, A, Mahmoodpoor, A, Donnelly, M, Breen, D, Ng, S, Bates, J, Sprung, C, Lev, A, Kishinevsky, E, Cohen, J, Sofer, S, Vesconi, S, Greco, S, Borelli, M, Cecilia, P, Sapuppo, M, Lazzero, A, Mangani, V, Petrucci, N, Minerva, M, Rummo, G, De blasio, E, Marzorati, S, Rosi, R, Giarratano, A, Margarit, O, Guberti, A, Scolz, S, Stelian, E, Emmi, V, Caspani, M, Rosano, A, Abbruzzese, C, Colonna, S, Ceriani, R, De Blasi, R, Panella, L, Borrelli, F, Lorella, P, Ruatti, H, Munch, C, Sorbara, C, Fiore, G, Chieregato, A, Conti, V, Guadagnucci, A, Pizzamiglio, M, Locicero, Mt, Marri, I, Sicignano, A, Conte, V, Oggioni, R, De Gasperi, A, De negri, P, Santagostino, G, Roberto, F, Marino, G, Castiglione, G, Sforza, D, Camillo, S, Giuseppe, N, Bassetti, Matteo, Napoli, D, Ferraro, F, Clementi, S, Di Filippo, A, Cotogni, P, Ranieri, Mv, Antonelli, M, Martinelli, L, Gianesello, L, Gullo, A, Morelli, A, Biancofiore, G, DELLA ROCCA, Giorgio, Hashimoto, S, Onodera, M, Kobayashi, A, Shinozuka, T, Imanaka, H, Ikeda, T, Yaguchi, A, Misane, I, Piebalga, A, Moughaghab, A, Pilvinis, V, Vosylius, S, Balciunas, M, Kekstas, G, Margaret, H, Klop, M, Grozdanovski, K, Eftimova, B, Wafa, S, Lim, C, Mat nor, M, Tai, L, Syed Mohd Tahir, S, Idris, N, Tan, C, Borg, M, Manzo, E, Gutierrez Morales, H, Miguel, P, Villagomez, A, Bassols, A, Aguirre, G, Cerón, U, Lopez ramos, J, Monjardín, J, Bermudez Aceves, E, Gonzalez Salazar, F, Rodriguez Gonzalez, D, Poblano Morales, M, Ramirez, F, Cetina, M, Navarro, J, Villagomez Ortiz, A, Sanchez, V, Chavarria, U, Fernandez Ponce, O, 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Nguyen Huu, C.

Published
2011

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