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2. Is the use of marginal donors justified in liver transplantation? Analysis of results and proposal of modern criteria

Author

De Carlis, L., Sansalone, C. V., Rondinara, G. F., Colella, G., Slim, A. O., Rossetti, O., Aseni, P., Della Volpe, A., Forti, D., Belli, L. S., Alberti, A., Fesce, R., Mühlbacher, Ferdinand, editor, Gnant, M., editor, Klepetko, W., editor, Längle, F., editor, Laufer, G., editor, Sautner, T., editor, Steininger, R., editor, Wamser, P., editor, and Kootstra, G., editor

Published
1996
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8. Abstract

Author

Andries, L. J., Sys, S. U., Meulemans, A. L., Schuurkes, J. A. J., Vanheel, B., Van de Voorde, J., De Smet, P., Li, J., Van Driessche, W., Flamion, B., Foulon, S., Abramow, M., Calders, P., Eechaute, W., Lacroix, E., Weyne, I., Hoeben, D., Burvenich, C., Fransen, P., Andries, L. J., Van Bedaf, D., Demolder, M., Sys, S. U., Ouedraogo, R., Lebrun, P., Herchuelz, A., Antoine, M. -H., Vandenput, S., Votion, D., Anciaux, N., Duvivier, D. H., Art, T., Lekeux, P., Votion, D., Ghafir, Y., Vandenput, S., Art, T., Lekeux, P., Geurts, M., Hermans, E., Maloteaux, J. -M., Perrad, B., Noel, B., Lagache, F., Bister, J. L., Paquay, R., Bister, J. L., Derycke, G., Vandermeir, M. A., Paquay, R., de Brouwer, S., Porret, C. -A., Stergiopulos, N., Meister, J. -J., Verbeke, M., Van de Voorde, J., Lameire, N., De Clerck, N. M., De Schuytter, J., Tytgato, J., Buyse, G., Eggermont, J., Droogmans, G., Nilius, B., Daenens, P., Salomone, S., Feron, O., Dessy, C., Morel, N., Godfraind, T., Aloisi, A. M., Sacerdote, P., Lodi, L., Carli, G., Carobi, C., Garinei, G., Miniaci, U. C., Scotto, P., Sabatino, M., Sardo, P., Iurato, L., La Grutta, V., Bagni, M. A., Cecchi, G., Cecchini, E., Colomo, F., Garzella, P., Bottinelli, R., Harridge, S. D. H., Canepari, M., Reggiani, C., Reggiani, Saltin, Bambagioni, D., Fanò, G., Menchetti, G,, Danieli-Betto, P., Esposito, A., Betto, R., Megighian, A., Midrio, M., Betto, D. Danieli, Esposito, A., Megighian, A., Midrio, M., Orizio, C., Liberati, D., Locatelli, C., De Grandis, D., Veicsteinas, A., Angoli, D., Delia, D., Wanke, E., Bramucci, M., Miano, A., Quassinti, L., Maccari, E., Murri, O., Amici, D., Cibelli, G., Jüngling, S., Schoch, S., Gerdest, H. H., Thiel, G., Demori, I., Bottazzi, C., Voci, A., Fugassa, E., Barreca, A., Minuto, F., Gallo, G., Fulle, S., Belia, S., Menchetti, G., Cacchio, M., Fanò, G., Gastaldi, G., Laforenza, U., Ferrari, G., Rindi, G., Doni, M. G., Padoin, E., Residori, O., Cesaro, M., Toma, L., Rubini, A., Mutinelli, F, Paulesu, L., Romagnolie, R., Cintorino, M., Pippia, P., Meloni, M. A., Sciola, L., Spano, A., Cogoli-Greuter, M., Cogoli, A., Sardini, A., Mintenig, G. M., Valverde, M. A., Sepùlveda, F. V., Gill, D. R., Hyde, S. C., Higgins, C. F., McNaughton, P. A., Spena, A., Arcuri, M. T., Bonofiglio, S., Chimenti, R., Covello, C., De Cicco, T., Mazzulla, S., Martino, G., Tottene, A., Moretti, A., Pietrobon, D., Baccari, M. C., Calamai, F., Staderini, G., Cova, E., Marelli, R., Sommi, P., Ventura, U., Lombardi, A. M., Fabris, R., Pagano, C., Federspil, G., Vettor, R., Mancinelli, R., Tonali, P., Servidei, S., Romani, R., Tringali, A., Azzena, G. B., Mulè, F., Serio, R., Postorino, A., Pagano, C., Rizzato, M., Granzotto, M., Lombardi, A. M., Fabris, R., Vettor, R., Federspil, G., Sommi, P., Ricci, V., Romano, M., Ivey, K. J., Ventura, U., Vacca, G., Papillo, B., Mary, D. A. S. G., Battaglia, A., Grossini, E., Vacca, G., Papillo, B., Battaglia, A., Grossini, E., Accili, E. A., Redaelli, G., DiFrancesco, D., Antoniotti, S., Distasi, C., Lovisolo, D., Munaron, L., Bertaso, F., Assandri, R., Mazzanti, M., Bianchi, L., Arcangeli, A., Faravelli, L., Becchetti, A., Coronello, M., Mini, E., Francini, F., Olivotto, M., Wanke, E., Bigiani, A., Kim, D. -J., Roper, S. D., Carabelli, V., Lovallo, M., Magnelli, V., Zucker, H., Carbone, E., D’Angelo, E., Rossi, P., De Filippi, G., Taglietti, V., Faravelli, L., Bianchi, L., Arcangeli, A., Francini, F., Olivotto, M., Wanke, E., Francini, F., Bencini, C., Squecco, R., Guatteo, E., Bacci, A., Franceschetti, S., Avanzini, G., Wanke, E., Magnelli, V., Carbone, E., Mazzanti, M., Assandri, R., Ferroni, A., DiFrancesco, D., Navangione, A., Vellani, V., Rispoli, G., Peres, A., Centinaio, E., Giovannardi, S., Russo, G., Marcotti, W., Prigioni, I., Trequattrini, C., Harper, A. A., Petris, A., Franciolini, F., Zaza, A., Micheletti, M., Brioschi, A., Antonutto, G., Capelli, C., Girardis, M., Zamparo, P., di Prampero, P. E., Antonutto, G., Girardis, M., Tuniz, D., di Prampero, P. E., Filippi, G. M., Troiani, D., Grassi, B., Poole, D. C., Richardson, R. S., Knight, D. R., Erickson, B. K., Wagner, P. D., Aimi, B., Stilli, D., Gallo, P., Sgoifo, A., Lagrasta, C., Olivetti, G., Reali, N., Casti, A., Musso, E., Alloatti, G., Penna, C., Gallo, M. P., Levi, R. C., Fenoglio, I., Appendino, G., Gallo, P., Sgoifo, A., Medici, D., Aimi, B., Manghi, M., Stilli, D., Musso, E., Sgoifo, A., Pasini, E., Gallo, P., Aimi, B., Stilli, D., Ceconi, C., Musso, E., Baldissera, F., Cavallari, P., Locatelli, M., Bartesaghi, R., Gessi, T., Benfenati, F., Valtorta, F., Onofri, F., Poo, M., Greengard, P., Biagini, G., Sala, D., Viani§, P., Kozlov, A. V., Zini, I., Bravin, M., Tempia, F., Strata, P., Brescia, G., Di Benedetto, C., Corsi, P., Cangiano, G., Buttiglione, M., Ambrosini, M., Gennarini, G., Casadio, A., Levi, R. C., Montarolo, P. G., Cesare, P., Stoughton, R., McNaughton, P. A., D’Arcangelo, G., Dodt, H. U., Brancati, A., Zieglgänsberger, W., Errico, P., Ferraresi, A., Barmack, N. H., Pettorossi, V. E., Gasparini, S., D’Ambrosio, R., Janigro, D., DiFrancesco, D., Gritti, I., Marintti, M., Calcaterra, R., Freddi, R., Mancia, M., Imeri, I., Bianchi, S., Mancia, M., Lui, F., Gregory, K. M., Blanks, R. H. I., Giolli, R. A., Benassi, C., Corazza, R., Magherini, P. C., Bardoni, R., Belluzzi, O., Mancinelli, R., Manni, E., Azzena, G. B., Tringali, A., Romani, R., Diana, M., Fratta, W., Manzoni, D., Andre, P., Pompeiano, O., Mazzocchio, R., Rossi, A., Melis, F., Kitura, A., Caria, M. A., Asanuma, H., Melone, M, De Biasi, S, Minelli, A, Conti, F, Minelli, A, Karschin, C, DeBiasi, S, Brecha, N C, Conti, F, Monda, M., Amaro, S., Sullo, A., De Luca, B., Monda, M., Amaro, S., Sullo, A., De Luca, B., Pantò, M. R., Cicirata, F., Parenti, R., Serapide, M. F., Parenti, R., Wassef, M., Cicirata, F., Podda, M. V., Solinas, A., Chessa, G., Deriu, F., Mameli, O., Tolu, E., Pompeiano, O., Andre, P., Manzoni, D., Porro, C. A., Francescato, M. P., Cettolo, V., Diamond, M. E., Baraldi, P., Bazzocchi, M., Rivosecchi, R., Konnerth, A., Rossi, M. L., Martini, M., Pelucchi, B., Fesce, R., Santarelli, L., Schacher, S., Montarolo, P. G., Santarelli, R., Grassi, C., Valente, A., Nisticò, S., Bagetta, G., Azzena, G. B., Scuri, Rossana, Garcia-Gil, Mercedes, Mozzachiodi, Riccardo, Brunelli, Marcello, Stefani, G., Onofri, F., Vaccaro, P., Nielander, H. B., Benfenati, F., Tancredi, V., D’Antuono, M., Siniscalchi, A., Brancati, A., Avoli, M., Vellani, V., Navangione, A., Rispoli, G., Verzè, L., Buffo, A., Rossi, F., Oestreicher, A. B., Gispen, W. H., Strata, P., Zamboni, G., Amici, R., Jones, C. A., Perez, E., Domeniconi, R., Parmeggiani, P. L., Zoli, Michele, Le Novàre, Nicolas, Changeux, Jean -Pierre, Lafortuna, C. L., Reinach, E., Saibene, F., Scotto, P., Zocchi, L., Agostoni, E., and Cremaschi, D.

Published
1996
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11. Maternal Immune Activation Delays Excitatory-to-Inhibitory Gamma-Aminobutyric Acid Switch in Offspring

Author

Corradini, I, Focchi, E, Rasile, M, Morini, R, Desiato, G, Tomasoni, R, Lizier, M, Ghirardini, E, Fesce, R, Morone, D, Barajon, I, Antonucci, F, Pozzi, D, Matteoli, M, Matteoli, M., Corradini, I, Focchi, E, Rasile, M, Morini, R, Desiato, G, Tomasoni, R, Lizier, M, Ghirardini, E, Fesce, R, Morone, D, Barajon, I, Antonucci, F, Pozzi, D, Matteoli, M, and Matteoli, M.

Abstract

Background: The association between maternal infection and neurodevelopmental defects in progeny is well established, although the biological mechanisms and the pathogenic trajectories involved have not been defined. Methods: Pregnant dams were injected intraperitoneally at gestational day 9 with polyinosinic:polycytidylic acid. Neuronal development was assessed by means of electrophysiological, optical, and biochemical analyses. Results: Prenatal exposure to polyinosinic:polycytidylic acid causes an imbalanced expression of the Na+-K+-2Cl− cotransporter 1 and the K+-Cl− cotransporter 2 (KCC2). This results in delayed gamma-aminobutyric acid switch and higher susceptibility to seizures, which endures up to adulthood. Chromatin immunoprecipitation experiments reveal increased binding of the repressor factor RE1-silencing transcription (also known as neuron-restrictive silencer factor) to position 509 of the KCC2 promoter that leads to downregulation of KCC2 transcription in prenatally exposed offspring. Interleukin-1 receptor type I knockout mice, which display braked immune response and no brain cytokine elevation upon maternal immune activation, do not display KCC2/Na+-K+-2Cl− cotransporter 1 imbalance when implanted in a wild-type dam and prenatally exposed. Notably, pretreatment of pregnant dams with magnesium sulfate is sufficient to prevent the early inflammatory state and the delay in excitatory-to-inhibitory switch associated to maternal immune activation. Conclusions: We provide evidence that maternal immune activation hits a key neurodevelopmental process, the excitatory-to-inhibitory gamma-aminobutyric acid switch; defects in this switch have been unequivocally linked to diseases such as autism spectrum disorder or epilepsy. These data open the avenue for a safe pharmacological treatment that may prevent the neurodevelopmental defects caused by prenatal immune activation in a specific pregnancy time window

Published
2018

13. Fisiologia, Molecole, cellule e sistemi

Author

Angioy A. M., Bardoni R., Biella G., Bigiani A., Bossi E., Brunelli M., Catacuzzeno L., Contestabile A., D'Angelo E., Fesce R., Fioretti B., Franciolini F., Fugassa E., Fulle S., Galimberti S., Ghirardelli R., Giovannardi S., Levi R., Lionetto M. G., Lombardi V., Macchi E., Negrini D., Paggi P., Palmero S., Peres A., perin P., Piccolino M., Poggesi C., Rispoli G., Rossi P., Sacchi V. F., Schettino T., Serio R., Valenti G., Vellani V., Zaza A., CRISPINO, MARIANNA, GIUDITTA, ANTONIO, D'Angelo E., Peres A., Angioy, A. M., Bardoni, R., Biella, G., Bigiani, A., Bossi, E., Brunelli, M., Catacuzzeno, L., Contestabile, A., Crispino, Marianna, D'Angelo, E., Fesce, R., Fioretti, B., Franciolini, F., Fugassa, E., Fulle, S., Galimberti, S., Ghirardelli, R., Giovannardi, S., Giuditta, Antonio, Levi, R., Lionetto, M. G., Lombardi, V., Macchi, E., Negrini, D., Paggi, P., Palmero, S., Peres, A., Perin, P., Piccolino, M., Poggesi, C., Rispoli, G., Rossi, P., Sacchi, V. F., Schettino, T., Serio, R., Valenti, G., Vellani, V., Zaza, A., and D'Angelo E, Peres A

Published
2007

14. Marginal donors in liver transplantation: The role of donor age

Author

De Carlis, L, Colella, G, Sansalone, C, Aseni, P, Rondinara, G, Slim, A, Di Benedetto, F, Giacomoni, A, Fesce, R, Forti, D, De Carlis, L., Colella, G., Sansalone, C. V., Aseni, P., Rondinara, G. F., Slim, A. O., Di Benedetto, F., Giacomoni, A., Fesce, R., Forti, D., De Carlis, L, Colella, G, Sansalone, C, Aseni, P, Rondinara, G, Slim, A, Di Benedetto, F, Giacomoni, A, Fesce, R, Forti, D, De Carlis, L., Colella, G., Sansalone, C. V., Aseni, P., Rondinara, G. F., Slim, A. O., Di Benedetto, F., Giacomoni, A., Fesce, R., and Forti, D.

Published
1999

19. Is the use of marginal donors justified in liver transplantation? Analysis of results and proposal of modern criteria

Author

De Carlis, L, Sansalone, C, Rondinara, G, Colella, G, Slim, A, Rossetti, O, Aseni, P, Della Volpe, A, Belli, L, Alberti, A, Fesce, R, Forti, D, De Carlis, L., Sansalone, C. V., Rondinara, G. F., Colella, G., Slim, A. O., Rossetti, O., Aseni, P., Della Volpe, A., Belli, L. S., Alberti, A., Fesce, R., Forti, D., De Carlis, L, Sansalone, C, Rondinara, G, Colella, G, Slim, A, Rossetti, O, Aseni, P, Della Volpe, A, Belli, L, Alberti, A, Fesce, R, Forti, D, De Carlis, L., Sansalone, C. V., Rondinara, G. F., Colella, G., Slim, A. O., Rossetti, O., Aseni, P., Della Volpe, A., Belli, L. S., Alberti, A., Fesce, R., and Forti, D.

Abstract

A discrepancy exists worldwide between the number of suitable liver donors and the increasing demand for transplantation. Thus many centers have considered widening their liver donor acceptance criteria and this may increase the incidence of primary dysfunction (PD) with negative effect on the results of transplantation. In order to reduce the incidence of PD and improve patient and graft survival it becomes important to identify those risk factors associated with its occurrence. In a retrospective univariate and multivariate analysis we evaluated several donor, preservation and recipient parameters and their correlation with PD. In our Department 282 orthotopic liver transplantations (OLT) were performed on 256 adult patients over a 10-year period. Excluded were 15 cases with early vascular problems and 4 intraoperative deaths. A complete series of donor, recipient and procedure-related data were analyzed. About 30% of donors showed abnormal values. In 70 cases of PD (26%) there was a 61.4% graft failure rate compared with 15% in the group with immediate function (P < 0.05). Univariate analysis showed donor age, steatosis, ischemia time, amines, oliguria, hypotension and ICU stay to be significantly associated with PD. Multivariate analysis showed steatosis, ischemia time and amine dosage to be independent risk factors for the development of primary non function. In conclusion, the acceptance of marginal donors worsened the results of transplantation, but the rejection of these donors would reduce by about 30% our transplant activity resulting in increased mortality in the waiting list. Combinations of risk factors when possible should be avoided, and ischemia time, as the only variable that can be controlled, should be kept as short as possible

Published
1996

20. Fisiologia

Author

Bardoni, R., Biella, G., Bigiani, A., Crispino, M., D' Angelo, E., De Stefano, M. E., Distasi, C., Fesce, R., Francolini, F., Fulle, S., Levi, R., Li Volsi, G., Lionetto, M. G., Lombardi, V., Macchi, E., Negrini, D., Palmero, S., Peres, A., Perin, P., Poggesi, C., Rispoli, Giorgio, Rossi, P., Vellea Sacchi, F., Schettino, T., Serio, R., Valenti, G., Vellani, V., Zaza, A., and Zoli, M.

Subjects
Fisiologia, Neurofisiologia, Biofisica, Biotecnologie, Farmacia, Medicina
Published
2011

26. Multilayered cellular automata in modeling biological systems

Author

BANDINI, STEFANIA, MAURI, GIANCARLO, Fesce, R, Malagutti, G, Bandini, S, Fesce, R, Malagutti, G, and Mauri, G

Subjects
cellular automata, INF/01 - INFORMATICA
Abstract

Cellular Automata constitute a promising approach in modeling complex biological systems characterized by local interactions, which occur in parallel and give rise to the intertwined evolution of several processes of interest. Multilayered cellular automata are here proposed as a computational dynamical model for representing and simulating complex biological systems. In particular, a two-layers cellular automaton is proposed for modeling reaction-diffusion processes. The specific case of calium ion distribution in the cell is also discussed

Published
1996

43. Block of glutamate-glutamine cycle between astrocytes and neurons inhibits epileptiform activity in hippocampus

Author

Bacci, A, Sancini, G, Verderio, C, Armano, S, Pravettoni, E, Fesce, R, Franceschetti, S, Matteoli, M, Matteoli, M., SANCINI, GIULIO ALFREDO, Bacci, A, Sancini, G, Verderio, C, Armano, S, Pravettoni, E, Fesce, R, Franceschetti, S, Matteoli, M, Matteoli, M., and SANCINI, GIULIO ALFREDO

Abstract

Recurrent epileptiform activity occurs spontaneously in cultured CNS neurons and in brain slices in which GABA inhibition has been blocked. We demonstrate here that pharmacological treatments resulting in either the block of glutamine production by astrocytes or the inhibition of glutamine uptake by neurons suppress or markedly decrease the frequency of spontaneous epileptiform discharges both in primary hippocampal cultures and in disinhibited hippocampal slices. These data point to an important role for the neuron-astrocyte metabolic interaction in sustaining episodes of intense rhythmic activity in the CNS, and thereby reveal a new potential target for antiepileptic treatments.

Published
2002

44. Neurotransmitter supply and demand in epilepsy

Author

Huguenard, J, Huguenard, J, Bacci, A, Sancini, G, Verderio, C, Armano, C, Pravettoni, E, Fesce, R, Franceschetti, S, Matteoli, M, Sepkuty, J, Cohen, A, Eccles, C, Rafiq, A, Behar, K, Ganel, R, Coulter, D, Rothstein, J, Sepkuty, JP, Cohen, AS, Coulter, DA, Rothstein, JD, SANCINI, GIULIO ALFREDO, Huguenard, J, Huguenard, J, Bacci, A, Sancini, G, Verderio, C, Armano, C, Pravettoni, E, Fesce, R, Franceschetti, S, Matteoli, M, Sepkuty, J, Cohen, A, Eccles, C, Rafiq, A, Behar, K, Ganel, R, Coulter, D, Rothstein, J, Sepkuty, JP, Cohen, AS, Coulter, DA, Rothstein, JD, and SANCINI, GIULIO ALFREDO

Published
2002

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