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5. Neuro‐Oncology

Author

Rees, Jeremy, primary, Brandner, Sebastian, additional, Fersht, Naomi, additional, Grieve, Joan, additional, Hotton, Gary, additional, Kosmin, Michael, additional, Russo, Vittorio, additional, Thorne, Lewis, additional, and Thust, Steffi, additional

Published
2024
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10. Isocitrate Dehydrogenase 1/2 Wildtype Adult Astrocytoma with WHO Grade 2/3 Histological Features: Molecular Re-Classification, Prognostic Factors, Clinical Outcomes.

Author

Gupta, Meetakshi, Anjari, Mustafa, Brandner, Sebastian, Fersht, Naomi, Wilson, Elena, Thust, Steffi, and Kosmin, Michael

Subjects
ISOCITRATE dehydrogenase, PROGNOSIS, ASTROCYTOMAS, TREATMENT effectiveness, ELECTRONIC health records
Abstract

Background: Isocitrate Dehydrogenase 1/2 (IDH 1/2)-wildtype (WT) astrocytomas constitute a heterogeneous group of tumors and have undergone a series of diagnostic reclassifications over time. This study aimed to investigate molecular markers, clinical, imaging, and treatment factors predictive of outcomes in WHO grade 2/3 IDH-WT astrocytomas ('early glioblastoma'). Methodology: Patients with WHO grade 2/3 IDH-WT astrocytomas were identified from the hospital archives. They were cross-referenced with the electronic medical records systems, including neuroimaging. The expert neuro-pathology team retrieved data on molecular markers—MGMT, TERT, IDH, and EGFR. Tumors with a TERT mutation and/or EGFR amplification were reclassified as glioblastoma. Results: Fifty-four patients were identified. Sixty-three percent of the patients could be conclusively reclassified as glioblastoma based on either TERT mutation, EGFR amplification, or both. On imaging, 65% showed gadolinium enhancement on MRI. Thirty-nine patients (72%) received long-course radiotherapy, of whom 64% received concurrent chemotherapy. The median follow-up of the group was 16 months (range: 2–90), and the median overall survival (OS) was 17.3 months. The 2-year OS of the whole cohort was 31%. On univariate analysis, older age, worse performance status (PS), and presence versus absence of contrast enhancement on diagnostic MRI were statistically significant for poorer OS. Conclusion: IDH-WT WHO grade 2/3 astrocytomas are a heterogeneous group of tumors with poor clinical outcomes. The majority can be reclassified as glioblastoma, based on current WHO classification criteria, but further understanding of the underlying biology of these tumors and the discovery of novel targeted agents are needed for better outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Integration of a personalised mobile health (mHealth) application into the care of patients with brain tumours: proof-of-concept study (IDEAL stage 1)

Author

Gvozdanovic, Andrew, primary, Jozsa, Felix, additional, Fersht, Naomi, additional, Grover, Patrick James, additional, Kirby, Georgina, additional, Kitchen, Neil, additional, Mangiapelo, Riccardo, additional, McEvoy, Andrew, additional, Miserocchi, Anna, additional, Patel, Rayna, additional, Thorne, Lewis, additional, Williams, Norman, additional, Kosmin, Michael, additional, and Marcus, Hani J, additional

Published
2022
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29. Landscape of Familial Isolated and Young-Onset Pituitary Adenomas: Prospective Diagnosis in AIP Mutation Carriers

Author

Hernández-Ramírez, Laura C., Gabrovska, Plamena, Dénes, Judit, Stals, Karen, Trivellin, Giampaolo, Tilley, Daniel, Ferraù, Francesco, Evanson, Jane, Ellard, Sian, Grossman, Ashley B., Roncaroli, Federico, Gadelha, Mônica R., Korbonits, Márta, Agha, Amar, Akker, Scott A., Aflorei, Elena D., Alföldi, Sándor, Arlt, Wiebke, Atkinson, Brew, Aulinas-Masó, Anna, Aylwin, Simon J., Backeljauw, Philippe F., Badiu, Corin, Baldeweg, Stephanie, Bano, Gul, Barkan, Ariel, Barwell, Julian, Bernal-González, Carmen, Besser, G. Michael, Bevan, John S., Blair, Jo, Bouloux, Pierre, Bradley, Lisa, Buchfelder, Michael, Cakir, Mehtap, Canham, Natalie, Carroll, Paul, Chahal, Harvinder S., Cheetham, Tim, Chentli, Farida, Clayton, Richard N., Cohen, Mark, Cole, Trevor, Courtney, Hamish, Crowne, Elizabeth, Cuthbertson, Daniel, Dal, Jacob, Dalantaeva, Nadezhda, Daousi, Christina, Darzy, Ken, Dattani, Mehul, Davies, Justin H., Davis, Julian, De Castro, Margaret, De Marinis, Laura, Drake, William, Dutta, Pinaki, Dzeranova, Larisa, Edén-Engström, Britt, Eeles, Rosalind, Elfving, Maria, Elston, Marianne, Emmerson, Louise, Fersht, Naomi, Fica, Simona, Fischli, Stefan, Flanagan, Daniel, Fleseriu, Maria, Freda, Pamela U., Friedman, Theodore, Frohman, Lawrence A., Gallego, Patricia, Gevers, Evelien, Gláz, Edit, Goldman, James A., Goldstone, Anthony P., Goth, Miklos, Greenhalgh, Lynn, Grieve, Joan, Guitelman, Mirtha, Gürlek, Alper, Gurnell, Mark, Horvath, Katalin, Howlett, Trevor A., Höybye, Charlotte, Hunter, Steven, Iacovazzo, Donato, Igaz, Peter, Inder, Warrick J., Iwata, Takeo, Izatt, Louise, Jagadeesh, Sujatha, Kaltsas, Gregory, Kaplan, Felicity, Karavitaki, Niki, Kastelan, Darko, Katz, Michelle, Kearney, Tara, Khoo, Bernard, Kiraly-Borri, Cathy, Knispelis, Robertas, Kovács, Gábor László, Kumar, Ajith V., Laws, Edward R., Jr, Lechan, Ronald M., Levy, Miles J., Lewandowski, Krzysztof, Lo, Janet, Maartens, Niki, Matsuno, Akira, McGowan, Barbara, McQuaid, Siobhán E., Medic-Stojanoska, Milica, Mercado-Atri, Moisés, Mezősi, Emese, Miljic, Dragana, Miller, Karen K., Modenesi, Silvia, Molitch, Mark E., Monson, John, Morris, Damian G., Morrison, Patrick J., Munir, Alia, Murray, Robert D., Musat, Madalina, Musolino, Nina, Nachtigall, Lisa, Newell-Price, John, Ogilvie, Arla, Orme, Steve M., Paşcanu, Ionela, Patócs, Attila, Patterson, Catherine, Pearce, Simon H., Pecori Giraldi, Francesca, Pfeifer, Marija, Popovic, Vera, Poplawski, Nicola, Powell, Michael, Pullan, Peter, Quinton, Richard, Radian, Serban, Randeva, Harpal, Ribeiro-Oliveira, Antônio, Jr, Rodd, Celia, Ryan, Fiona, Salvatori, Roberto, Schöfl, Christof, Shears, Debbie, Shotliff, Kevin, Soares, Beatriz S., Somasundaram, Noel, Spada, Anna, Sperber, James, Spoudeas, Helen A., Stewart, Susan, Storr, Helen, Strasburger, Christian, Street, Maria Elisabeth, Swords, Francesca, Thakker, Rajesh V., Tham, Elaine, Thompson, Chris, Thorner, Dr Michael O., Tóth, Miklós, Trainer, Peter J., Tsagarakis, Stylianos, Tzanela, Marinella, Vadász, János, Vaks, Vladimir, Verkauskiene, Rasa, Wass, John A., Webb, Susan M., Weber, Astrid, Yamada, Shozo, Yarman, Sema, Yeoh, Philip, Yoshimoto, Katsuhiko, and Zammitt, Nicola N.

Published
2015

31. Heterogeneous Genetic Background of the Association of Pheochromocytoma/Paraganglioma and Pituitary Adenoma: Results From a Large Patient Cohort

Author

Dénes, Judit, Swords, Francesca, Rattenberry, Eleanor, Stals, Karen, Owens, Martina, Cranston, Treena, Xekouki, Paraskevi, Moran, Linda, Kumar, Ajith, Wassif, Christopher, Fersht, Naomi, Baldeweg, Stephanie E., Morris, Damian, Lightman, Stafford, Agha, Amar, Rees, Aled, Grieve, Joan, Powell, Michael, Boguszewski, Cesar Luiz, Dutta, Pinaki, Thakker, Rajesh V., Srirangalingam, Umasuthan, Thompson, Chris J., Druce, Maralyn, Higham, Claire, Davis, Julian, Eeles, Rosalind, Stevenson, Mark, OʼSullivan, Brendan, Taniere, Phillipe, Skordilis, Kassiani, Gabrovska, Plamena, Barlier, Anne, Webb, Susan M., Aulinas, Anna, Drake, William M., Bevan, John S., Preda, Cristina, Dalantaeva, Nadezhda, Ribeiro-Oliveira, Antônio, Jr, Garcia, Isabel Tena, Yordanova, Galina, Iotova, Violeta, Evanson, Jane, Grossman, Ashley B., Trouillas, Jacqueline, Ellard, Sian, Stratakis, Constantine A., Maher, Eamonn R., Roncaroli, Federico, and Korbonits, Márta

Published
2015

33. The histology of brain tumors for 67 331 children and 671 085 adults diagnosed in 60 countries during 2000-2014: a global, population-based study (CONCORD-3)

Author

Girardi, Fabio, Rous, Brian, Stiller, Charles A, Gatta, Gemma, Fersht, Naomi, Storm, Hans H, Rodrigues, Jessica R, Herrmann, Christian, Marcos-Gragera, Rafael, Peris-Bonet, Rafael, Valkov, Mikhail, Weir, Hannah K, Woods, Ryan R, You, Hui, Cueva, Patricia A, De, Prithwish, Di Carlo, Veronica, Johannesen, Tom Børge, Lima, Carlos A, Lynch, Charles F, Coleman, Michel P, Allemani, Claudia, Bouzbid, S, Šekerija, M, Lewis, C, CONCORD Working Group, Girardi F., Rous B., Stiller C.A., Gatta G., Fersht N., Storm H.H., Rodrigues J.R., Herrmann C., Marcos-Gragera R., Peris-Bonet R., Valkov M., Weir H.K., Woods R.R., You H., Cueva P.A., De P., Di Carlo V., Johannesen T.Bo., Lima C.A., Lynch C.F., Coleman M.P., Allemani C., Mazzucco W., University of Zurich, and Girardi, Fabio

Subjects
Adult, Pediatrics, medicine.medical_specialty, Cancer Research, epidemiological study, population-based cancer registries, Databases, Factual, Population, health care disparities, histology, International Classification of Diseases, primary brain tumor, Socio-culturale, Cancer registration, 610 Medicine & health, Astrocytoma, 03 medical and health sciences, Global population, 0302 clinical medicine, epidemiological study, health care disparities, histology, International Classification of Diseases, population-based cancer registries, primary brain tumor, medicine, Humans, 1306 Cancer Research, Registries, education, Child, Medulloblastoma, education.field_of_study, business.industry, Brain Neoplasms, Cancer, Histology, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), medicine.disease, Europe, 2728 Neurology (clinical), Oncology, 030220 oncology & carcinogenesis, Population study, 2730 Oncology, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

Background Global variations in survival for brain tumors are very wide when all histological types are considered together. Appraisal of international differences should be informed by the distribution of histology, but little is known beyond Europe and North America. Methods The source for the analysis was the CONCORD database, a program of global surveillance of cancer survival trends, which includes the tumor records of individual patients from more than 300 population-based cancer registries. We considered all patients aged 0-99 years who were diagnosed with a primary brain tumor during 2000-2014, whether malignant or nonmalignant. We presented the histology distribution of these tumors, for patients diagnosed during 2000-2004, 2005-2009, and 2010-2014. Results Records were submitted from 60 countries on 5 continents, 67 331 for children and 671 085 for adults. After exclusion of irrelevant morphology codes, the final study population comprised 60 783 children and 602 112 adults. Only 59 of 60 countries covered in CONCORD-3 were included because none of the Mexican records were eligible. We defined 12 histology groups for children, and 11 for adults. In children (0-14 years), the proportion of low-grade astrocytomas ranged between 6% and 50%. Medulloblastoma was the most common subtype in countries where low-grade astrocytoma was less commonly reported. In adults (15-99 years), the proportion of glioblastomas varied between 9% and 69%. International comparisons were made difficult by wide differences in the proportion of tumors with unspecified histology, which accounted for up to 52% of diagnoses in children and up to 65% in adults. Conclusions To our knowledge, this is the first account of the global histology distribution of brain tumors, in children and adults. Our findings provide insights into the practices and the quality of cancer registration worldwide.

Published
2021

35. Implementation of the Vinehealth application, a digital health tool, into the care of patients living with brain cancer.

Author

Gvozdanovic, Andrew, primary, Mangiapelo, Riccardo, additional, Patel, Rayna, additional, Kirby, Georgina, additional, Kitchen, Neil, additional, Miserocchi, Anna, additional, McEvoy, Andy, additional, Grover, Patrick, additional, Thorne, Lewis, additional, Fersht, Naomi, additional, Williams, Norman R., additional, Marcus, Hani, additional, and Kosmin, Michael, additional

Published
2021
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36. The histology of brain tumors for 67 331 children and 671 085 adults diagnosed in 60 countries during 2000-2014: a global, population-based study (CONCORD-3)

Author

Girardi, Fabio;Rous, Brian;Stiller, Charles A;Gatta, Gemma;Fersht, Naomi;Storm, Hans H;Rodrigues, Jessica R;Herrmann, Christian;Marcos-Gragera, Rafael;Peris-Bonet, Rafael;Valkov, Mikhail;Weir, Hannah K;Woods, Ryan R;You, Hui;Cueva, Patricia A;De, Prithwish;Di Carlo, Veronica;Johannesen, Tom Børge;Lima, Carlos A;Lynch, Charles F;Coleman, Michel P;Allemani, Claudia;Bouzbid, S;Hamdi-Chérif, M;Zaidi, Z;Meguenni, K;Regagba, D;Bayo, S;Cheick Bougadari, T;Manraj, S S;Bendahhou, K;Ladipo, A;Ogunbiyi, O J;Ramaliba, T;Somdyala, N I M;Chaplin, M A;Moreno, F;Calabrano, G H;Espinola, S B;Carballo Quintero, B;Fita, R;Laspada, W D;Ibañez, S G;Lima, C A;Mafra da Costa, A;De Souza, P C F;Del Pino, K;Laporte, C;Curado, M P;de Oliveira, J C;Veneziano, C L A;Veneziano, D B;Latorre, M R D O;Tanaka, L F;Rebelo, M S;Santos, M O;Azevedo e Silva, G;Galaz, J C;Aparicio Aravena, M;Sanhueza Monsalve, J;Herrmann, D A;Vargas, S;Herrera, V M;Uribe, C J;Bravo, L E;Garcia, L S;Arias-Ortiz, N E;Morantes, D;Jurado, D M;Yépez Chamorro, M C;Delgado, S;Ramirez, M;Galán Alvarez, Y H;Torres, P;Martínez-Reyes, F;Jaramillo, L;Quinto, R;Castillo, J;Mendoza, M;Cueva, P;Yépez, J G;Bhakkan, B;Deloumeaux, J;Joachim, C;Macni, J;Carrillo, R;Shalkow Klincovstein, J;Rivera Gomez, R;Perez, P;Poquioma, E;Tortolero-Luna, G;Zavala, D;Alonso, R;Barrios, E;Eckstrand, A;Nikiforuk, C;Woods, R R;Noonan, G;Turner, D;Kumar, E;Zhang, B;McCrate, F R;Ryan, S;MacIntyre, M;Saint-Jacques, N;Anam, A;De, P;McClure, C A;Vriends, K A;Bertrand, C;Latreille, J;Kozie, S;Stuart-Panko, H;Freeman, T;George, J T;Avila, R M;O’Brien, D K;Holt, A;Almon, L;Kwong, S;Morris, C;Rycroft, R;Mueller, L;Phillips, C E;Brown, H;Cromartie, B;Schwartz, A G;Vigneau, F;Levin, G M;Wohler, B;Bayakly, R;Ward, K C;Gomez, S L;McKinley, M;Cress, R;Green, M D;Miyagi, K;Johnson, C J;Ruppert, L P;Bentler, S;Charlton, M E;Huang, B;Tucker, T C;Deapen, D;Liu, L;Hsieh, M C;Wu, X C;Schwenn, M;Stern, K;Gershman, S T;Knowlton, R C;Alverson, G;Weaver, T;Bushhouse, S;Rogers, D and Girardi, Fabio;Rous, Brian;Stiller, Charles A;Gatta, Gemma;Fersht, Naomi;Storm, Hans H;Rodrigues, Jessica R;Herrmann, Christian;Marcos-Gragera, Rafael;Peris-Bonet, Rafael;Valkov, Mikhail;Weir, Hannah K;Woods, Ryan R;You, Hui;Cueva, Patricia A;De, Prithwish;Di Carlo, Veronica;Johannesen, Tom Børge;Lima, Carlos A;Lynch, Charles F;Coleman, Michel P;Allemani, Claudia;Bouzbid, S;Hamdi-Chérif, M;Zaidi, Z;Meguenni, K;Regagba, D;Bayo, S;Cheick Bougadari, T;Manraj, S S;Bendahhou, K;Ladipo, A;Ogunbiyi, O J;Ramaliba, T;Somdyala, N I M;Chaplin, M A;Moreno, F;Calabrano, G H;Espinola, S B;Carballo Quintero, B;Fita, R;Laspada, W D;Ibañez, S G;Lima, C A;Mafra da Costa, A;De Souza, P C F;Del Pino, K;Laporte, C;Curado, M P;de Oliveira, J C;Veneziano, C L A;Veneziano, D B;Latorre, M R D O;Tanaka, L F;Rebelo, M S;Santos, M O;Azevedo e Silva, G;Galaz, J C;Aparicio Aravena, M;Sanhueza Monsalve, J;Herrmann, D A;Vargas, S;Herrera, V M;Uribe, C J;Bravo, L E;Garcia, L S;Arias-Ortiz, N E;Morantes, D;Jurado, D M;Yépez Chamorro, M C;Delgado, S;Ramirez, M;Galán Alvarez, Y H;Torres, P;Martínez-Reyes, F;Jaramillo, L;Quinto, R;Castillo, J;Mendoza, M;Cueva, P;Yépez, J G;Bhakkan, B;Deloumeaux, J;Joachim, C;Macni, J;Carrillo, R;Shalkow Klincovstein, J;Rivera Gomez, R;Perez, P;Poquioma, E;Tortolero-Luna, G;Zavala, D;Alonso, R;Barrios, E;Eckstrand, A;Nikiforuk, C;Woods, R R;Noonan, G;Turner, D;Kumar, E;Zhang, B;McCrate, F R;Ryan, S;MacIntyre, M;Saint-Jacques, N;Anam, A;De, P;McClure, C A;Vriends, K A;Bertrand, C;Latreille, J;Kozie, S;Stuart-Panko, H;Freeman, T;George, J T;Avila, R M;O’Brien, D K;Holt, A;Almon, L;Kwong, S;Morris, C;Rycroft, R;Mueller, L;Phillips, C E;Brown, H;Cromartie, B;Schwartz, A G;Vigneau, F;Levin, G M;Wohler, B;Bayakly, R;Ward, K C;Gomez, S L;McKinley, M;Cress, R;Green, M D;Miyagi, K;Johnson, C J;Ruppert, L P;Bentler, S;Charlton, M E;Huang, B;Tucker, T C;Deapen, D;Liu, L;Hsieh, M C;Wu, X C;Schwenn, M;Stern, K;Gershman, S T;Knowlton, R C;Alverson, G;Weaver, T;Bushhouse, S;Rogers, D

Published
2020

38. Temporal trends in craniopharyngioma management and long‐term endocrine outcomes: A multicentre cross‐sectional study

Author

Hussein, Ziad, primary, Glynn, Nigel, additional, Martin, Niamh, additional, Alkrekshi, Akram, additional, Mendoza, Nigel, additional, Nair, Ramesh, additional, McCullough, Katherine, additional, Marcus, Hani J., additional, Dorward, Neil, additional, Grieve, Joan, additional, Fersht, Naomi, additional, Dyson, Edward, additional, Bouloux, Pierre‐Marc, additional, Druce, Maralyn, additional, and Baldeweg, Stephanie E., additional

Published
2020
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39. Hydroxychloroquine and short-course radiotherapy in elderly patients with newly diagnosed high-grade glioma: a randomized phase II trial

Author

Brazil, Lucy, primary, Swampillai, Angela L, primary, Mak, Ka Man, primary, Edwards, Darren, primary, Mesiri, Pavlina, primary, Clifton-Hadley, Laura, primary, Shaffer, Richard, primary, Lewis, Joanne, primary, Watts, Colin, primary, Jeffries, Sarah, primary, Gkogkou, Pinelopi, primary, Chalmers, Anthony J, primary, Fersht, Naomi L, primary, Hackshaw, Allan, primary, and Short, Susan C, primary

Published
2020
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43. Temporal trends in craniopharyngioma management and long‐term endocrine outcomes: A multicentre cross‐sectional study.

Author

Hussein, Ziad, Glynn, Nigel, Martin, Niamh, Alkrekshi, Akram, Mendoza, Nigel, Nair, Ramesh, McCullough, Katherine, Marcus, Hani J., Dorward, Neil, Grieve, Joan, Fersht, Naomi, Dyson, Edward, Bouloux, Pierre‐Marc, Druce, Maralyn, and Baldeweg, Stephanie E.

Subjects
CRANIOPHARYNGIOMA, CROSS-sectional method, TREATMENT effectiveness, ADRENOCORTICOTROPIC hormone, CURRICULUM
Abstract

Background: The optimal management of craniopharyngiomas remains controversial. Objectives: To examine temporal trends in the management of craniopharyngioma with a focus on endocrine outcomes. Methods: This was a cross‐sectional, multicentre study. Patients treated between 1951 and 2015 were identified and divided into four quartiles. Demographics, presentation, treatment and outcomes were collected. Results: In total, 142 patients with childhood‐onset craniopharyngioma (48/142; 34%) and adult‐onset disease (94/142; 66%) were included. The median follow‐up was 15 years (IQR 5‐23 years). Across quartiles, there was a significant trend towards using transsphenoidal surgery (P <.0001). The overall use of radiotherapy was not different among the four quartiles (P =.33). At the latest clinical review, the incidence of GH, ACTH, gonadotrophin deficiencies and anterior panhypopituitarism fell significantly across the duration of the study. Anterior panhypopituitarism was not affected by treatment modality (surgery vs surgery and radiotherapy) (P =.23). There was no difference in the incidence of high BMI (≥25 kg/m2) among the four quartiles (P =.14). BMI was higher in patients who treated with surgery and radiotherapy than those treated with surgery only (P =.006). Tumour regrowth occurred in 51 patients (51/142; 36%) with no difference in regrowth among quartiles over the time course of the study (P =.15). Conclusion: We demonstrate a significant reduction in panhypopituitarism in craniopharyngioma patients over time, most likely because of a trend towards more transsphenoidal surgery. However, long‐term endocrine sequelae remain common and lifelong follow‐up is required. [ABSTRACT FROM AUTHOR]

Published
2021
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45. Metastatic pituitary carcinoma in an SDHB mutation positive patient

Author

Tufton, Nicola, primary, Roncaroli, Federico, additional, Hadjudemetriou, Irene, additional, Dang, Mary N, additional, Denes, Judit, additional, Guasti, Leonardo, additional, Thom, Maria, additional, Powell, Michael, additional, Baldeweg, Stephanie E, additional, Fersht, Naomi, additional, and Korbonits, Marta, additional

Published
2017
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48. Neuro‐Oncology

Author

Rees, Jeremy, primary, Bradford, Robert, additional, Brandner, Sebastian, additional, Fersht, Naomi, additional, Jäger, Rolf, additional, and Wilson, Elena, additional

Published
2016
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