146 results on '"Ferrucci, Veronica"'
Search Results
2. Modulation of innate immunity related genes resulting in prophylactic antimicrobial and antiviral properties
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Ferrucci, Veronica, Miceli, Marco, Pagliuca, Chiara, Bianco, Orazio, Castaldo, Luigi, Izzo, Luana, Cozzolino, Marica, Zannella, Carla, Oglio, Franca, Polcaro, Antonio, Randazzo, Antonio, Colicchio, Roberta, Galdiero, Massimiliano, Berni Canani, Roberto, Salvatore, Paola, and Zollo, Massimo
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- 2024
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3. PRUNE1 and NME/NDPK family proteins influence energy metabolism and signaling in cancer metastases
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Ferrucci, Veronica, Lomada, Santosh, Wieland, Thomas, and Zollo, Massimo
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- 2024
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4. SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB
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Monaco, Vittoria, Iacobucci, Ilaria, Canè, Luisa, Cipollone, Irene, Ferrucci, Veronica, de Antonellis, Pasqualino, Quaranta, Miriana, Pascarella, Stefano, Zollo, Massimo, and Monti, Maria
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- 2024
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5. Failure of human rhombic lip differentiation underlies medulloblastoma formation
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Hendrikse, Liam D, Haldipur, Parthiv, Saulnier, Olivier, Millman, Jake, Sjoboen, Alexandria H, Erickson, Anders W, Ong, Winnie, Gordon, Victor, Coudière-Morrison, Ludivine, Mercier, Audrey L, Shokouhian, Mohammad, Suárez, Raúl A, Ly, Michelle, Borlase, Stephanie, Scott, David S, Vladoiu, Maria C, Farooq, Hamza, Sirbu, Olga, Nakashima, Takuma, Nambu, Shohei, Funakoshi, Yusuke, Bahcheli, Alec, Diaz-Mejia, J Javier, Golser, Joseph, Bach, Kathleen, Phuong-Bao, Tram, Skowron, Patryk, Wang, Evan Y, Kumar, Sachin A, Balin, Polina, Visvanathan, Abhirami, Lee, John JY, Ayoub, Ramy, Chen, Xin, Chen, Xiaodi, Mungall, Karen L, Luu, Betty, Bérubé, Pierre, Wang, Yu C, Pfister, Stefan M, Kim, Seung-Ki, Delattre, Olivier, Bourdeaut, Franck, Doz, François, Masliah-Planchon, Julien, Grajkowska, Wieslawa A, Loukides, James, Dirks, Peter, Fèvre-Montange, Michelle, Jouvet, Anne, French, Pim J, Kros, Johan M, Zitterbart, Karel, Bailey, Swneke D, Eberhart, Charles G, Rao, Amulya AN, Giannini, Caterina, Olson, James M, Garami, Miklós, Hauser, Peter, Phillips, Joanna J, Ra, Young S, de Torres, Carmen, Mora, Jaume, Li, Kay KW, Ng, Ho-Keung, Poon, Wai S, Pollack, Ian F, López-Aguilar, Enrique, Gillespie, G Yancey, Van Meter, Timothy E, Shofuda, Tomoko, Vibhakar, Rajeev, Thompson, Reid C, Cooper, Michael K, Rubin, Joshua B, Kumabe, Toshihiro, Jung, Shin, Lach, Boleslaw, Iolascon, Achille, Ferrucci, Veronica, de Antonellis, Pasqualino, Zollo, Massimo, Cinalli, Giuseppe, Robinson, Shenandoah, Stearns, Duncan S, Van Meir, Erwin G, Porrati, Paola, Finocchiaro, Gaetano, Massimino, Maura, Carlotti, Carlos G, Faria, Claudia C, Roussel, Martine F, Boop, Frederick, Chan, Jennifer A, Aldinger, Kimberly A, Razavi, Ferechte, Silvestri, Evelina, McLendon, Roger E, and Thompson, Eric M
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Stem Cell Research ,Brain Disorders ,Neurosciences ,Rare Diseases ,Stem Cell Research - Nonembryonic - Non-Human ,Aetiology ,1.1 Normal biological development and functioning ,Underpinning research ,2.1 Biological and endogenous factors ,Cell Differentiation ,Cell Lineage ,Cerebellar Neoplasms ,Cerebellum ,Core Binding Factor alpha Subunits ,Hedgehog Proteins ,Histone Demethylases ,Humans ,Ki-67 Antigen ,Medulloblastoma ,Metencephalon ,Muscle Proteins ,Mutation ,Otx Transcription Factors ,Repressor Proteins ,T-Box Domain Proteins ,Transcription Factors ,General Science & Technology - Abstract
Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain1-4. Mutations that activate Sonic hedgehog signalling lead to Sonic hedgehog MB in the upper rhombic lip (RL) granule cell lineage5-8. By contrast, mutations that activate WNT signalling lead to WNT MB in the lower RL9,10. However, little is known about the more commonly occurring group 4 (G4) MB, which is thought to arise in the unipolar brush cell lineage3,4. Here we demonstrate that somatic mutations that cause G4 MB converge on the core binding factor alpha (CBFA) complex and mutually exclusive alterations that affect CBFA2T2, CBFA2T3, PRDM6, UTX and OTX2. CBFA2T2 is expressed early in the progenitor cells of the cerebellar RL subventricular zone in Homo sapiens, and G4 MB transcriptionally resembles these progenitors but are stalled in developmental time. Knockdown of OTX2 in model systems relieves this differentiation blockade, which allows MB cells to spontaneously proceed along normal developmental differentiation trajectories. The specific nature of the split human RL, which is destined to generate most of the neurons in the human brain, and its high level of susceptible EOMES+KI67+ unipolar brush cell progenitor cells probably predisposes our species to the development of G4 MB.
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- 2022
6. The physiological polyphosphate as a healing biomaterial for chronic wounds: Crucial roles of its antibacterial and unique metabolic energy supplying properties
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Müller, Werner E.G., Schepler, Hadrian, Neufurth, Meik, Wang, Shunfeng, Ferrucci, Veronica, Zollo, Massimo, Tan, Rongwei, Schröder, Heinz C., and Wang, Xiaohong
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- 2023
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7. Heterogeneity within the PF-EPN-B ependymoma subgroup
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Cavalli, Florence MG, Hübner, Jens-Martin, Sharma, Tanvi, Luu, Betty, Sill, Martin, Zapotocky, Michal, Mack, Stephen C, Witt, Hendrik, Lin, Tong, Shih, David JH, Ho, Ben, Santi, Mariarita, Emery, Lyndsey, Hukin, Juliette, Dunham, Christopher, McLendon, Roger E, Lipp, Eric S, Gururangan, Sridharan, Grossbach, Andrew, French, Pim, Kros, Johan M, van Veelen, Marie-Lise C, Rao, Amulya A Nageswara, Giannini, Caterina, Leary, Sarah, Jung, Shin, Faria, Claudia C, Mora, Jaume, Schüller, Ulrich, Alonso, Marta M, Chan, Jennifer A, Klekner, Almos, Chambless, Lola B, Hwang, Eugene I, Massimino, Maura, Eberhart, Charles G, Karajannis, Matthias A, Lu, Benjamin, Liau, Linda M, Zollo, Massimo, Ferrucci, Veronica, Carlotti, Carlos, Tirapelli, Daniela PC, Tabori, Uri, Bouffet, Eric, Ryzhova, Marina, Ellison, David W, Merchant, Thomas E, Gilbert, Mark R, Armstrong, Terri S, Korshunov, Andrey, Pfister, Stefan M, Taylor, Michael D, Aldape, Kenneth, Pajtler, Kristian W, Kool, Marcel, and Ramaswamy, Vijay
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Genetics ,Cancer ,Clinical Research ,Rare Diseases ,Human Genome ,Brain Cancer ,Brain Disorders ,Adolescent ,Adult ,Age Factors ,Child ,Cohort Studies ,DNA Copy Number Variations ,DNA Methylation ,Ependymoma ,Female ,Gene Expression Profiling ,Humans ,Infratentorial Neoplasms ,Kaplan-Meier Estimate ,Male ,Microarray Analysis ,Middle Aged ,Young Adult ,Posterior fossa ,Subgrouping ,PFB ,PFA ,Clustering ,Clinical Sciences ,Neurosciences ,Neurology & Neurosurgery - Abstract
Posterior fossa ependymoma comprise three distinct molecular variants, termed PF-EPN-A (PFA), PF-EPN-B (PFB), and PF-EPN-SE (subependymoma). Clinically, they are very disparate and PFB tumors are currently being considered for a trial of radiation avoidance. However, to move forward, unraveling the heterogeneity within PFB would be highly desirable. To discern the molecular heterogeneity within PFB, we performed an integrated analysis consisting of DNA methylation profiling, copy-number profiling, gene expression profiling, and clinical correlation across a cohort of 212 primary posterior fossa PFB tumors. Unsupervised spectral clustering and t-SNE analysis of genome-wide methylation data revealed five distinct subtypes of PFB tumors, termed PFB1-5, with distinct demographics, copy-number alterations, and gene expression profiles. All PFB subtypes were distinct from PFA and posterior fossa subependymomas. Of the five subtypes, PFB4 and PFB5 are more discrete, consisting of younger and older patients, respectively, with a strong female-gender enrichment in PFB5 (age: p = 0.011, gender: p = 0.04). Broad copy-number aberrations were common; however, many events such as chromosome 2 loss, 5 gain, and 17 loss were enriched in specific subtypes and 1q gain was enriched in PFB1. Late relapses were common across all five subtypes, but deaths were uncommon and present in only two subtypes (PFB1 and PFB3). Unlike the case in PFA ependymoma, 1q gain was not a robust marker of poor progression-free survival; however, chromosome 13q loss may represent a novel marker for risk stratification across the spectrum of PFB subtypes. Similar to PFA ependymoma, there exists a significant intertumoral heterogeneity within PFB, with distinct molecular subtypes identified. Even when accounting for this heterogeneity, extent of resection remains the strongest predictor of poor outcome. However, this biological heterogeneity must be accounted for in future preclinical modeling and personalized therapies.
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- 2018
8. Prune-1 drives polarization of tumor-associated macrophages (TAMs) within the lung metastatic niche in triple-negative breast cancer
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Ferrucci, Veronica, Asadzadeh, Fatemeh, Collina, Francesca, Siciliano, Roberto, Boccia, Angelo, Marrone, Laura, Spano, Daniela, Carotenuto, Marianeve, Chiarolla, Cristina Maria, De Martino, Daniela, De Vita, Gennaro, Macrì, Alessandra, Dassi, Luisa, Vandenbussche, Jonathan, Marino, Natascia, Cantile, Monica, Paolella, Giovanni, D'Andrea, Francesco, di Bonito, Maurizio, Gevaert, Kris, and Zollo, Massimo
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- 2021
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9. A Structurally Simple Vaccine Candidate Reduces Progression and Dissemination of Triple-Negative Breast Cancer
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Amedei, Amedeo, Asadzadeh, Fatemeh, Papi, Francesco, Vannucchi, Maria Giuliana, Ferrucci, Veronica, Bermejo, Iris A., Fragai, Marco, De Almeida, Carolina Vieira, Cerofolini, Linda, Giuntini, Stefano, Bombaci, Mauro, Pesce, Elisa, Niccolai, Elena, Natali, Francesca, Guarini, Eleonora, Gabel, Frank, Traini, Chiara, Catarinicchia, Stefano, Ricci, Federica, Orzalesi, Lorenzo, Berti, Francesco, Corzana, Francisco, Zollo, Massimo, Grifantini, Renata, and Nativi, Cristina
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- 2020
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10. Targeting Group 3 Medulloblastoma by the Anti-PRUNE-1 and Anti-LSD1/KDM1A Epigenetic Molecules
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Bibbò, Francesca, primary, Asadzadeh, Fatemeh, additional, Boccia, Angelo, additional, Sorice, Carmen, additional, Bianco, Orazio, additional, Saccà, Carmen Daniela, additional, Majello, Barbara, additional, Donofrio, Vittoria, additional, Bifano, Delfina, additional, De Martino, Lucia, additional, Quaglietta, Lucia, additional, Cristofano, Adriana, additional, Covelli, Eugenio Maria, additional, Cinalli, Giuseppe, additional, Ferrucci, Veronica, additional, De Antonellis, Pasqualino, additional, and Zollo, Massimo, additional
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- 2024
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11. Author Correction: Failure of human rhombic lip differentiation underlies medulloblastoma formation
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Hendrikse, Liam D., Haldipur, Parthiv, Saulnier, Olivier, Millman, Jake, Sjoboen, Alexandria H., Erickson, Anders W., Ong, Winnie, Gordon, Victor, Coudière-Morrison, Ludivine, Mercier, Audrey L., Shokouhian, Mohammad, Suárez, Raúl A., Ly, Michelle, Borlase, Stephanie, Scott, David S., Vladoiu, Maria C., Farooq, Hamza, Sirbu, Olga, Nakashima, Takuma, Nambu, Shohei, Funakoshi, Yusuke, Bahcheli, Alec, Diaz-Mejia, J. Javier, Golser, Joseph, Bach, Kathleen, Phuong-Bao, Tram, Skowron, Patryk, Wang, Evan Y., Kumar, Sachin A., Balin, Polina, Visvanathan, Abhirami, Lee, John J. Y., Ayoub, Ramy, Chen, Xin, Chen, Xiaodi, Mungall, Karen L., Luu, Betty, Bérubé, Pierre, Wang, Yu C., Pfister, Stefan M., Kim, Seung-Ki, Delattre, Olivier, Bourdeaut, Franck, Doz, François, Masliah-Planchon, Julien, Grajkowska, Wieslawa A., Loukides, James, Dirks, Peter, Fèvre-Montange, Michelle, Jouvet, Anne, French, Pim J., Kros, Johan M., Zitterbart, Karel, Bailey, Swneke D., Eberhart, Charles G., Rao, Amulya A. N., Giannini, Caterina, Olson, James M., Garami, Miklós, Hauser, Peter, Phillips, Joanna J., Ra, Young S., de Torres, Carmen, Mora, Jaume, Li, Kay K. W., Ng, Ho-Keung, Poon, Wai S., Pollack, Ian F., López-Aguilar, Enrique, Gillespie, G. Yancey, Van Meter, Timothy E., Shofuda, Tomoko, Vibhakar, Rajeev, Thompson, Reid C., Cooper, Michael K., Rubin, Joshua B., Kumabe, Toshihiro, Jung, Shin, Lach, Boleslaw, Iolascon, Achille, Ferrucci, Veronica, de Antonellis, Pasqualino, Zollo, Massimo, Cinalli, Giuseppe, Robinson, Shenandoah, Stearns, Duncan S., Van Meir, Erwin G., Porrati, Paola, Finocchiaro, Gaetano, Massimino, Maura, Carlotti, Carlos G., Faria, Claudia C., Roussel, Martine F., Boop, Frederick, Chan, Jennifer A., Aldinger, Kimberly A., Razavi, Ferechte, Silvestri, Evelina, McLendon, Roger E., Thompson, Eric M., Ansari, Marc, Garre, Maria L., Chico, Fernando, Eguía, Pilar, Pérezpeña, Mario, Morrissy, A. Sorana, Cavalli, Florence M. G., Wu, Xiaochong, Daniels, Craig, Rich, Jeremy N., Jones, Steven J. M., Moore, Richard A., Marra, Marco A., Huang, Xi, Reimand, Jüri, Sorensen, Poul H., Wechsler-Reya, Robert J., Weiss, William A., Pugh, Trevor J., Garzia, Livia, Kleinman, Claudia L., Stein, Lincoln D., Jabado, Nada, Malkin, David, Ayrault, Olivier, Golden, Jeffrey A., Ellison, David W., Doble, Brad, Ramaswamy, Vijay, Werbowetski-Ogilvie, Tamra E., Suzuki, Hiromichi, Millen, Kathleen J., and Taylor, Michael D.
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- 2022
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12. Novel human neutralizing mAbs specific for Spike-RBD of SARS-CoV-2
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Passariello, Margherita, Gentile, Chiara, Ferrucci, Veronica, Sasso, Emanuele, Vetrei, Cinzia, Fusco, Giovanna, Viscardi, Maurizio, Brandi, Sergio, Cerino, Pellegrino, Zambrano, Nicola, Zollo, Massimo, and De Lorenzo, Claudia
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- 2021
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13. A competitive cell-permeable peptide impairs Nme-1 (NDPK-A) and Prune-1 interaction: therapeutic applications in cancer
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Ferrucci, Veronica, Pennino, Francesco Paolo, Siciliano, Roberto, Asadzadeh, Fatemeh, and Zollo, Massimo
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- 2018
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14. Epigenetics and immune cells in medulloblastoma
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Gorini, Francesca, primary, Miceli, Marco, additional, de Antonellis, Pasqualino, additional, Amente, Stefano, additional, Zollo, Massimo, additional, and Ferrucci, Veronica, additional
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- 2023
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15. DDDR-32. A NEW IMMUNOMODULATORY FUNCTION OF PYRIDO-PYRIMIDINE DERIVATIVES TO IMPAIR METASTATIC GROUP 3 MEDULLOBLASTOMA IN VIVO
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Zollo, Massimo, primary, Asadzadeh, Fatemeh, additional, Ferrucci, Veronica, additional, De Antonellis, Pasqualino, additional, Bibbò, Francesca, additional, Siciliano, Roberto, additional, Sorice, Carmen, additional, Criscuolo, Giuseppina, additional, Filiz, Dalim Kardelen, additional, Tecik, Melisa, additional, Amente, Stefano, additional, Saccà, Carmen Daniela, additional, Gorini, Francesca, additional, Pedone, Emilia, additional, Diana, Donatella, additional, Pirone, Luciano, additional, Fattorusso, Roberto, additional, Navas, Luigi, additional, Donofrio, Vittoria, additional, Errico, Maria Elena, additional, Spennato, Pietro, additional, De Martino, Lucia, additional, Quaglietta, Lucia, additional, Tirone, Felice, additional, and Cinalli, Giuseppe, additional
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- 2022
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16. Natural compounds for pediatric cancer treatment
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Ferrucci, Veronica, Boffa, Iolanda, De Masi, Gina, and Zollo, Massimo
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- 2016
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17. Targeting ATP2B1 impairs PI3K/Akt/Fox-O3 signaling and reduces SARS-COV-2 replication in vivo
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de Antonellis, Pasqualino, primary, Ferrucci, Veronica, additional, Bibbo, Francesca, additional, Asadzadeh, Fathemeh, additional, Gorini, Francesca, additional, Boccia, Angelo, additional, Sorice, Carmen, additional, Siciliano, Roberto, additional, Russo, Roberta, additional, Andolfo, Immacolata, additional, Lasorsa, Vito Alessandro, additional, Cantalupo, Sueva, additional, Paolella, Giovanni, additional, Fusco, Giovanna, additional, Viscardi, Maurizio, additional, Brandi, Sergio, additional, Pierri, Bianca Maria, additional, Cerino, Pellegrino, additional, Monaco, Vittoria, additional, choi, Dong-Rac, additional, Cheong, Jae-Ho, additional, Monti, Maria, additional, Iolascon, Achille, additional, Amente, Stefano, additional, Capasso, Mario, additional, Kim, Hong-Yeoul, additional, and Zollo, Massimo, additional
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- 2022
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18. Germline rare variants of lectin pathway genes predispose to asymptomatic SARS-CoV-2 infection in elderly individuals
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D’Alterio, Giuseppe, primary, Lasorsa, Vito Alessandro, additional, Bonfiglio, Ferdinando, additional, Cantalupo, Sueva, additional, Rosato, Barbara Eleni, additional, Andolfo, Immacolata, additional, Russo, Roberta, additional, Esposito, Umberto, additional, Frisso, Giulia, additional, Abete, Pasquale, additional, Cassese, Gian Marco, additional, Servillo, Giuseppe, additional, Gentile, Ivan, additional, Piscopo, Carmelo, additional, Della Monica, Matteo, additional, Fiorentino, Giuseppe, additional, Boccia, Angelo, additional, Paolella, Giovanni, additional, Ferrucci, Veronica, additional, de Antonellis, Pasqualino, additional, Siciliano, Roberto, additional, Asadzadeh, Fathem, additional, Cerino, Pellegrino, additional, Buonerba, Carlo, additional, Pierri, Biancamaria, additional, Zollo, Massimo, additional, Iolascon, Achille, additional, and Capasso, Mario, additional
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- 2022
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19. A Novel Human Neutralizing mAb Recognizes Delta, Gamma and Omicron Variants of SARS-CoV-2 and Can Be Used in Combination with Sotrovimab
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Passariello, Margherita, primary, Ferrucci, Veronica, additional, Sasso, Emanuele, additional, Manna, Lorenzo, additional, Lembo, Rosa Rapuano, additional, Pascarella, Stefano, additional, Fusco, Giovanna, additional, Zambrano, Nicola, additional, Zollo, Massimo, additional, and De Lorenzo, Claudia, additional
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- 2022
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20. SARS-CoV-2 Pandemic Tracing in Italy Highlights Lineages with Mutational Burden in Growing Subsets
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Boccia, Angelo, primary, Tufano, Rossella, additional, Ferrucci, Veronica, additional, Sepe, Leandra, additional, Bianchi, Martina, additional, Pascarella, Stefano, additional, Zollo, Massimo, additional, and Paolella, Giovanni, additional
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- 2022
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21. Loss of Detection of sgN Precedes Viral Abridged Replication in COVID-19-Affected Patients—A Target for SARS-CoV-2 Propagation
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Ferrucci, Veronica, primary, de Antonellis, Pasqualino, additional, Quarantelli, Fabrizio, additional, Asadzadeh, Fatemeh, additional, Bibbò, Francesca, additional, Siciliano, Roberto, additional, Sorice, Carmen, additional, Pisano, Ida, additional, Izzo, Barbara, additional, Di Domenico, Carmela, additional, Boccia, Angelo, additional, Vargas, Maria, additional, Pierri, Biancamaria, additional, Viscardi, Maurizio, additional, Brandi, Sergio, additional, Fusco, Giovanna, additional, Cerino, Pellegrino, additional, De Pietro, Livia, additional, Furfaro, Ciro, additional, Napolitano, Leonardo Antonio, additional, Paolella, Giovanni, additional, Festa, Lidia, additional, Marzinotto, Stefania, additional, Conte, Maria Concetta, additional, Gentile, Ivan, additional, Servillo, Giuseppe, additional, Curcio, Francesco, additional, de Cristofaro, Tiziana, additional, Broccolo, Francesco, additional, Capoluongo, Ettore, additional, and Zollo, Massimo, additional
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- 2022
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22. A New Butyrate Releaser Exerts a Protective Action against SARS-CoV-2 Infection in Human Intestine
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Paparo, Lorella, primary, Maglio, Maria Antonia, additional, Cortese, Maddalena, additional, Bruno, Cristina, additional, Capasso, Mario, additional, Punzo, Erika, additional, Ferrucci, Veronica, additional, Lasorsa, Vito Alessandro, additional, Viscardi, Maurizio, additional, Fusco, Giovanna, additional, Cerino, Pellegrino, additional, Romano, Alessia, additional, Troncone, Riccardo, additional, and Zollo, Massimo, additional
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- 2022
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23. Protective effects elicited by cow milk fermented with L. Paracasei CBAL74 against SARS-CoV-2 infection in human enterocytes
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Paparo, Lorella, Bruno, Cristina, Ferrucci, Veronica, Punto, Erika, Viscardi, Maurizio, Fusco, Giovanna, Cerino, Pellegrino, Romano, Alessia, Zollo, Massimo, and Berni Canani, Roberto
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- 2021
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24. Durability of Humoral Immune Responses to SARS-CoV-2 in Citizens of Ariano Irpino (Campania, Italy): A Longitudinal Observational Study With an 11.5-Month Follow-Up
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Coppola, Annachiara, primary, Buonerba, Carlo, additional, Cardinale, Davide, additional, Lo Conte, Gabriella, additional, Sansone, Donato, additional, Rofrano, Giuseppe, additional, De Vita, Sabato, additional, Morgante, Maria, additional, Triassi, Maria, additional, Atripaldi, Luigi, additional, Brambilla, Gianfranco, additional, Sabatino, Rocco, additional, Pierri, Andrea, additional, Pacella, Daniela, additional, Pizzolante, Antonio, additional, Pierri, Biancamaria, additional, Ferrucci, Veronica, additional, Zollo, Massimo, additional, Capasso, Mario, additional, Stringhini, Silvia, additional, Ascierto, Paolo Antonio, additional, Roperto, Sante, additional, and Cerino, Pellegrino, additional
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- 2021
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25. Identification of SARS-CoV-2 Proteins from Nasopharyngeal Swabs Probed by Multiple Reaction Monitoring Tandem Mass Spectrometry
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Pinto, Gabriella, primary, Illiano, Anna, additional, Ferrucci, Veronica, additional, Quarantelli, Fabrizio, additional, Fontanarosa, Carolina, additional, Siciliano, Roberto, additional, Di Domenico, Carmela, additional, Izzo, Barbara, additional, Pucci, Piero, additional, Marino, Gennaro, additional, Zollo, Massimo, additional, and Amoresano, Angela, additional
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- 2021
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26. Functional Genomics of PRUNE1 in Neurodevelopmental Disorders (NDDs) Tied to Medulloblastoma (MB) and Other Tumors
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Bibbò, Francesca, primary, Sorice, Carmen, additional, Ferrucci, Veronica, additional, and Zollo, Massimo, additional
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- 2021
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27. MicroRNA 199b-5p delivery through stable nucleic acid lipid particles (SNALPs) in tumorigenic cell lines
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de Antonellis, Pasqualino, Liguori, Lucia, Falanga, Annarita, Carotenuto, Marianeve, Ferrucci, Veronica, Andolfo, Immacolata, Marinaro, Federica, Scognamiglio, Immacolata, Virgilio, Antonella, De Rosa, Giuseppe, Galeone, Aldo, Galdiero, Stefania, and Zollo, Massimo
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- 2013
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28. Long-chain polyphosphates impair SARS-CoV-2 infection and replication
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Ferrucci, Veronica, primary, Kong, Dae-Young, additional, Asadzadeh, Fatemeh, additional, Marrone, Laura, additional, Boccia, Angelo, additional, Siciliano, Roberto, additional, Criscuolo, Giuseppina, additional, Anastasio, Camilla, additional, Quarantelli, Fabrizio, additional, Comegna, Marika, additional, Pisano, Ida, additional, Passariello, Margherita, additional, Iacobucci, Ilaria, additional, Monica, Rosa Della, additional, Izzo, Barbara, additional, Cerino, Pellegrino, additional, Fusco, Giovanna, additional, Viscardi, Maurizio, additional, Brandi, Sergio, additional, Pierri, Bianca Maria, additional, Borriello, Giorgia, additional, Tiberio, Claudia, additional, Atripaldi, Luigi, additional, Bianchi, Martina, additional, Paolella, Giovanni, additional, Capoluongo, Ettore, additional, Castaldo, Giuseppe, additional, Chiariotti, Lorenzo, additional, Monti, Maria, additional, De Lorenzo, Claudia, additional, Yun, Kyong-Seop, additional, Pascarella, Stefano, additional, Cheong, Jae-Ho, additional, Kim, Hong-Yeoul, additional, and Zollo, Massimo, additional
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- 2021
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29. Seroprevalence of SARS-CoV-2 Assessed by Four Chemiluminescence Immunoassays and One Immunocromatography Test for SARS-Cov-2
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Cerino, Pellegrino, primary, Gallo, Alfonso, additional, Pierri, Biancamaria, additional, Buonerba, Carlo, additional, Di Concilio, Denise, additional, Cuomo, Maria Concetta, additional, Vassallo, Lucia, additional, Lo Conte, Gabriella, additional, Coppola, Annachiara, additional, Pizzolante, Antonio, additional, Boccia, Giovanni, additional, Ferrucci, Veronica, additional, Atripaldi, Luigi, additional, Triassi, Maria, additional, Pacella, Daniela, additional, Cennamo, Michele, additional, Romano, Paolo, additional, Sorbo, Teresa Maria, additional, Furno, Alessandro, additional, Catapano, Oriana, additional, Contina, Aldo, additional, Perruolo, Giuseppe, additional, D'Amora, Maurizio, additional, Terracciano, Daniela, additional, and Portella, Giuseppe, additional
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- 2021
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30. SARS-CoV-2 Subgenomic N (sgN) Transcripts in Oro-Nasopharyngeal Swabs Correlate with the Highest Viral Load, as Evaluated by Five Different Molecular Methods
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Zollo, Massimo, primary, Ferrucci, Veronica, additional, Izzo, Barbara, additional, Quarantelli, Fabrizio, additional, Domenico, Carmela Di, additional, Comegna, Marika, additional, Paolillo, Carmela, additional, Amato, Felice, additional, Siciliano, Roberto, additional, Castaldo, Giuseppe, additional, and Capoluongo, Ettore, additional
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- 2021
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31. Long-chain polyphosphates impair SARS-CoV-2 infection and replication: a route for therapy in man
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Ferrucci, Veronica, primary, Kong, Dae-Young, additional, Asadzadeh, Fatemeh, additional, Marrone, Laura, additional, Siciliano, Roberto, additional, Cerino, Pellegrino, additional, Criscuolo, Giuseppina, additional, Pisano, Ida, additional, Quarantelli, Fabrizio, additional, Izzo, Barbara, additional, Fusco, Giovanna, additional, Comegna, Marika, additional, Boccia, Angelo, additional, Viscardi, Maurizio, additional, Borriello, Giorgia, additional, Brandi, Sergio, additional, Pierri, Bianca Maria, additional, Tiberio, Claudia, additional, Atripaldi, Luigi, additional, Paolella, Giovanni, additional, Castaldo, Giuseppe, additional, Pascarella, Stefano, additional, Bianchi, Martina, additional, Monica, Rosa Della, additional, Chiariotti, Lorenzo, additional, Yun, Kyong-Seop, additional, Cheong, Jae-Ho, additional, Kim, Hong-Yeoul, additional, and Zollo, Massimo, additional
- Published
- 2020
- Full Text
- View/download PDF
32. AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders
- Author
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Salpietro Vincenzo, Dixon Christine L., Guo Hui, Bello Oscar D., Vandrovcova Jana, Efthymiou Stephanie, Maroofian Reza, Heimer Gali, Burglen Lydie, Valence Stephanie, Torti Erin, Hacke Moritz, Rankin Julia, Tariq Huma, Colin Estelle, Procaccio Vincent, Striano Pasquale, Mankad Kshitij, Lieb Andreas, Chen Sharon, Pisani Laura, Bettencourt Conceicao, Mannikko Roope, Manole Andreea, Brusco Alfredo, Grosso Enrico, Ferrero Giovanni Battista, Armstrong-Moron Judith, Gueden Sophie, Bar-Yosef Omer, Tzadok Michal, Monaghan Kristin G., Santiago-Sim Teresa, Person Richard E., Cho Megan T., Willaert Rebecca, Yoo Yongjin, Chae Jong-Hee, Quan Yingting, Wu Huidan, Wang Tianyun, Bernier Raphael A., Xia Kun, Blesson Alyssa, Jain Mahim, Motazacker Mohammad M., Jaeger Bregje, Schneider Amy L., Boysen Katja, Muir Alison M., Myers Candace T., Gavrilova Ralitza H., Gunderson Lauren, Schultz-Rogers Laura, Klee Eric W., Dyment David, Osmond Matthew, Parellada Mara, Llorente Cloe, Gonzalez-Penas Javier, Carracedo Angel, Van Haeringen Arie, Ruivenkamp Claudia, Nava Caroline, Heron Delphine, Nardello Rosaria, Iacomino Michele, Minetti Carlo, Skabar Aldo, Fabretto Antonella, Chez Michael, Tsai Anne, Fassi Emily, Shinawi Marwan, Constantino John N., De Zorzi Rita, Fortuna Sara, Kok Fernando, Keren Boris, Bonneau Dominique, Choi Murim, Benzeev Bruria, Zara Federico, Mefford Heather C., Scheffer Ingrid E., Clayton-Smith Jill, Macaya Alfons, Rothman James E., Eichler Evan E., Kullmann Dimitri M., Houlden Henry, Raspall-Chaure Miquel, Hanna Michael G., Bugiardini Enrico, Hostettler Isabel, O'Callaghan Benjamin, Khan Alaa, Cortese Andrea, O'Connor Emer, Yau Wai Y., Bourinaris Thomas, Kaiyrzhanov Rauan, Chelban Viorica, Madej Monika, Diana Maria C., Vari Maria S., Pedemonte Marina, Bruno Claudio, Balagura Ganna, Scala Marcello, Fiorillo Chiara, Nobili Lino, Malintan Nancy T., Zanetti Maria N., Krishnakumar Shyam S., Lignani Gabriele, Jepson James E. C., Broda Paolo, Baldassari Simona, Rossi Pia, Fruscione Floriana, Madia Francesca, Traverso Monica, De-Marco Patrizia, Perez-Duenas Belen, Munell Francina, Kriouile Yamna, El-Khorassani Mohamed, Karashova Blagovesta, Avdjieva Daniela, Kathom Hadil, Tincheva Radka, Van-Maldergem Lionel, Nachbauer Wolfgang, Boesch Sylvia, Gagliano Antonella, Amadori Elisabetta, Goraya Jatinder S., Sultan Tipu, Kirmani Salman, Ibrahim Shahnaz, Jan Farida, Mine, Jun, Banu Selina, Veggiotti Pierangelo, Zuccotti Gian V, Ferrari Michel D., Van Den Maagdenberg Arn M. J., Verrotti Alberto, Marseglia Gian L., Savasta Salvatore, Soler Miguel A., Scuderi Carmela, Borgione Eugenia, Chimenz Roberto, Gitto Eloisa, Dipasquale Valeria, Sallemi Alessia, Fusco Monica, Cuppari Caterina, Cutrupi Maria C., Ruggieri Martino, Cama Armando, Capra Valeria, Mencacci Niccolo E., Boles Richard, Gupta Neerja, Kabra Madhulika, Papacostas Savvas, Zamba-Papanicolaou Eleni, Dardiotis Efthymios, Maqbool Shazia, Rana Nuzhat, Atawneh Osama, Lim Shen Y., Shaikh Farooq, Koutsis George, Breza Marianthi, Coviello Domenico A., Dauvilliers Yves A., AlKhawaja Issam, AlKhawaja Mariam, Al-Mutairi Fuad, Stojkovic Tanya, Ferrucci Veronica, Zollo Massimo, Alkuraya Fowzan S., Kinali Maria, Sherifa Hamed, Benrhouma Hanene, Turki Ilhem B. Y., Tazir Meriem, Obeid Makram, Bakhtadze Sophia, Saadi Nebal W., Zaki Maha S., Triki Chahnez C., Benfenati Fabio, Gustincich Stefano, Kara Majdi, Belcastro Vincenzo, Specchio Nicola, Capovilla Giuseppe, Karimiani Ehsan G., Salih Ahmed M., Okubadejo Njideka U., Ojo Oluwadamilola O., Oshinaike Olajumoke O., Oguntunde Olapeju, Wahab Kolawole, Bello Abiodun H., Abubakar Sanni, Obiabo Yahaya, Nwazor Ernest, Ekenze Oluchi, Williams Uduak, Iyagba Alagoma, Taiwo Lolade, Komolafe Morenikeji, Senkevich Konstantin, Shashkin Chingiz, Zharkynbekova Nazira, Koneyev Kairgali, Manizha Ganieva, Isrofilov Maksud, Guliyeva Ulviyya, Salayev Kamran, Khachatryan Samson, Rossi Salvatore, Silvestri Gabriella, Haridy Nourelhoda, Ramenghi Luca A., Xiromerisiou Georgia, David Emanuele, Aguennouz Mhammed, Fidani Liana, Spanaki Cleanthe, Tucci Arianna, Salpietro Vincenzo, Dixon Christine L., Guo Hui, Bello Oscar D., Vandrovcova Jana, Efthymiou Stephanie, Maroofian Reza, Heimer Gali, Burglen Lydie, Valence Stephanie, Torti Erin, Hacke Moritz, Rankin Julia, Tariq Huma, Colin Estelle, Procaccio Vincent, Striano Pasquale, Mankad Kshitij, Lieb Andreas, Chen Sharon, Pisani Laura, Bettencourt Conceicao, Mannikko Roope, Manole Andreea, Brusco Alfredo, Grosso Enrico, Ferrero Giovanni Battista, Armstrong-Moron Judith, Gueden Sophie, Bar-Yosef Omer, Tzadok Michal, Monaghan Kristin G., Santiago-Sim Teresa, Person Richard E., Cho Megan T., Willaert Rebecca, Yoo Yongjin, Chae Jong-Hee, Quan Yingting, Wu Huidan, Wang Tianyun, Bernier Raphael A., Xia Kun, Blesson Alyssa, Jain Mahim, Motazacker Mohammad M., Jaeger Bregje, Schneider Amy L., Boysen Katja, Muir Alison M., Myers Candace T., Gavrilova Ralitza H., Gunderson Lauren, Schultz-Rogers Laura, Klee Eric W., Dyment David, Osmond Matthew, Parellada Mara, Llorente Cloe, Gonzalez-Penas Javier, Carracedo Angel, Van Haeringen Arie, Ruivenkamp Claudia, Nava Caroline, Heron Delphine, Nardello Rosaria, Iacomino Michele, Minetti Carlo, Skabar Aldo, Fabretto Antonella, Chez Michael, Tsai Anne, Fassi Emily, Shinawi Marwan, Constantino John N., De Zorzi Rita, Fortuna Sara, Kok Fernando, Keren Boris, Bonneau Dominique, Choi Murim, Benzeev Bruria, Zara Federico, Mefford Heather C., Scheffer Ingrid E., Clayton-Smith Jill, Macaya Alfons, Rothman James E., Eichler Evan E., Kullmann Dimitri M., Houlden Henry, Raspall-Chaure Miquel, Hanna Michael G., Bugiardini Enrico, Hostettler Isabel, O'Callaghan Benjamin, Khan Alaa, Cortese Andrea, O'Connor Emer, Yau Wai Y., Bourinaris Thomas, Kaiyrzhanov Rauan, Chelban Viorica, Madej Monika, Diana Maria C., Vari Maria S., Pedemonte Marina, Bruno Claudio, Balagura Ganna, Scala Marcello, Fiorillo Chiara, Nobili Lino, Malintan Nancy T., Zanetti Maria N., Krishnakumar Shyam S., Lignani Gabriele, Jepson James E. C., Broda Paolo, Baldassari Simona, Rossi Pia, Fruscione Floriana, Madia Francesca, Traverso Monica, De-Marco Patrizia, Perez-Duenas Belen, Munell Francina, Kriouile Yamna, El-Khorassani Mohamed, Karashova Blagovesta, Avdjieva Daniela, Kathom Hadil, Tincheva Radka, Van-Maldergem Lionel, Nachbauer Wolfgang, Boesch Sylvia, Gagliano Antonella, Amadori Elisabetta, Goraya Jatinder S., Sultan Tipu, Kirmani Salman, Ibrahim Shahnaz, Jan Farida, Mine, Jun, Banu Selina, Veggiotti Pierangelo, Zuccotti Gian V, Ferrari Michel D., Van Den Maagdenberg Arn M. J., Verrotti Alberto, Marseglia Gian L., Savasta Salvatore, Soler Miguel A., Scuderi Carmela, Borgione Eugenia, Chimenz Roberto, Gitto Eloisa, Dipasquale Valeria, Sallemi Alessia, Fusco Monica, Cuppari Caterina, Cutrupi Maria C., Ruggieri Martino, Cama Armando, Capra Valeria, Mencacci Niccolo E., Boles Richard, Gupta Neerja, Kabra Madhulika, Papacostas Savvas, Zamba-Papanicolaou Eleni, Dardiotis Efthymios, Maqbool Shazia, Rana Nuzhat, Atawneh Osama, Lim Shen Y., Shaikh Farooq, Koutsis George, Breza Marianthi, Coviello Domenico A., Dauvilliers Yves A., AlKhawaja Issam, AlKhawaja Mariam, Al-Mutairi Fuad, Stojkovic Tanya, Ferrucci Veronica, Zollo Massimo, Alkuraya Fowzan S., Kinali Maria, Sherifa Hamed, Benrhouma Hanene, Turki Ilhem B. Y., Tazir Meriem, Obeid Makram, Bakhtadze Sophia, Saadi Nebal W., Zaki Maha S., Triki Chahnez C., Benfenati Fabio, Gustincich Stefano, Kara Majdi, Belcastro Vincenzo, Specchio Nicola, Capovilla Giuseppe, Karimiani Ehsan G., Salih Ahmed M., Okubadejo Njideka U., Ojo Oluwadamilola O., Oshinaike Olajumoke O., Oguntunde Olapeju, Wahab Kolawole, Bello Abiodun H., Abubakar Sanni, Obiabo Yahaya, Nwazor Ernest, Ekenze Oluchi, Williams Uduak, Iyagba Alagoma, Taiwo Lolade, Komolafe Morenikeji, Senkevich Konstantin, Shashkin Chingiz, Zharkynbekova Nazira, Koneyev Kairgali, Manizha Ganieva, Isrofilov Maksud, Guliyeva Ulviyya, Salayev Kamran, Khachatryan Samson, Rossi Salvatore, Silvestri Gabriella, Haridy Nourelhoda, Ramenghi Luca A., Xiromerisiou Georgia, David Emanuele, Aguennouz Mhammed, Fidani Liana, Spanaki Cleanthe, and Tucci Arianna
- Published
- 2019
33. AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders
- Author
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Vincenzo, Salpietro, Christine L, Dixon, Hui, Guo, Oscar D, Bello, Jana, Vandrovcova, Stephanie, Efthymiou, Reza, Maroofian, Gali, Heimer, Lydie, Burglen, Stephanie, Valence, Erin, Torti, Moritz, Hacke, Julia, Rankin, Huma, Tariq, Estelle, Colin, Vincent, Procaccio, Pasquale, Striano, Kshitij, Mankad, Andreas, Lieb, Sharon, Chen, Laura, Pisani, Conceicao, Bettencourt, Roope, Männikkö, Andreea, Manole, Alfredo, Brusco, Enrico, Grosso, Giovanni Battista, Ferrero, Judith, Armstrong-Moron, Sophie, Gueden, Omer, Bar-Yosef, Michal, Tzadok, Kristin G, Monaghan, Teresa, Santiago-Sim, Richard E, Person, Megan T, Cho, Rebecca, Willaert, Yongjin, Yoo, Jong-Hee, Chae, Yingting, Quan, Huidan, Wu, Tianyun, Wang, Raphael A, Bernier, Kun, Xia, Alyssa, Blesson, Mahim, Jain, Mohammad M, Motazacker, Bregje, Jaeger, Amy L, Schneider, Katja, Boysen, Alison M, Muir, Candace T, Myer, Ralitza H, Gavrilova, Lauren, Gunderson, Laura, Schultz-Roger, Eric W, Klee, David, Dyment, Matthew, Osmond, Mara, Parellada, Cloe, Llorente, Javier, Gonzalez-Peña, Angel, Carracedo, Arie, Van Haeringen, Claudia, Ruivenkamp, Caroline, Nava, Delphine, Heron, Rosaria, Nardello, Michele, Iacomino, Carlo, Minetti, Aldo, Skabar, Antonella, Fabretto, Hanna, Michael G., Bugiardini, Enrico, Hostettler, Isabel, O’Callaghan, Benjamin, Khan, Alaa, Cortese, Andrea, O’Connor, Emer, Yau, Wai Y., Bourinaris, Thoma, Kaiyrzhanov, Rauan, Chelban, Viorica, Madej, Monika, Diana, Maria C., Vari, Maria S., Pedemonte, Marina, Bruno, Claudio, Balagura, Ganna, Scala, Marcello, Fiorillo, Chiara, Nobili, Lino, Malintan, Nancy T., Zanetti, Maria N., Krishnakumar, Shyam S., Lignani, Gabriele, Jepson, James E. C., Broda, Paolo, Baldassari, Simona, Rossi, Pia, Fruscione, Floriana, Madia, Francesca, Traverso, Monica, De-Marco, Patrizia, Pérez-Dueñas, Belen, Munell, Francina, Kriouile, Yamna, El-Khorassani, Mohamed, Karashova, Blagovesta, Avdjieva, Daniela, Kathom, Hadil, Tincheva, Radka, Van-Maldergem, Lionel, Nachbauer, Wolfgang, Boesch, Sylvia, Gagliano, Antonella, Amadori, Elisabetta, Goraya, Jatinder S., Sultan, Tipu, Kirmani, Salman, Ibrahim, Shahnaz, Jan, Farida, Mine, Jun, Banu, Selina, Veggiotti, Pierangelo, Zuccotti, Gian V., Ferrari, Michel D., Van Den Maagdenberg, Arn M. J., Verrotti, Alberto, Marseglia, Gian L., Savasta, Salvatore, Soler, Miguel A., Scuderi, Carmela, Borgione, Eugenia, Chimenz, Roberto, Gitto, Eloisa, Dipasquale, Valeria, Sallemi, Alessia, Fusco, Monica, Cuppari, Caterina, Cutrupi, Maria C., Ruggieri, Martino, Cama, Armando, Capra, Valeria, Mencacci, Niccolò E., Boles, Richard, Gupta, Neerja, Kabra, Madhulika, Papacostas, Savva, Zamba-Papanicolaou, Eleni, Dardiotis, Efthymio, Maqbool, Shazia, Rana, Nuzhat, Atawneh, Osama, Lim, Shen Y., Shaikh, Farooq, Koutsis, George, Breza, Marianthi, Coviello, Domenico A., Dauvilliers, Yves A., Alkhawaja, Issam, Alkhawaja, Mariam, Al-Mutairi, Fuad, Stojkovic, Tanya, Ferrucci, Veronica, Zollo, Massimo, Alkuraya, Fowzan S., Kinali, Maria, Sherifa, Hamed, Benrhouma, Hanene, Turki, Ilhem B. Y., Tazir, Meriem, Obeid, Makram, Bakhtadze, Sophia, Saadi, Nebal W., Zaki, Maha S., Triki, Chahnez C., Benfenati, Fabio, Gustincich, Stefano, Kara, Majdi, Belcastro, Vincenzo, Specchio, Nicola, Capovilla, Giuseppe, Karimiani, Ehsan G., Salih, Ahmed M., Okubadejo, Njideka U., Ojo, Oluwadamilola O., Oshinaike, Olajumoke O., Oguntunde, Olapeju, Wahab, Kolawole, Bello, Abiodun H., Abubakar, Sanni, Obiabo, Yahaya, Nwazor, Ernest, Ekenze, Oluchi, Williams, Uduak, Iyagba, Alagoma, Taiwo, Lolade, Komolafe, Morenikeji, Senkevich, Konstantin, Shashkin, Chingiz, Zharkynbekova, Nazira, Koneyev, Kairgali, Manizha, Ganieva, Isrofilov, Maksud, Guliyeva, Ulviyya, Salayev, Kamran, Khachatryan, Samson, Rossi, Salvatore, Silvestri, Gabriella, Haridy, Nourelhoda, Ramenghi, Luca A., Xiromerisiou, Georgia, David, Emanuele, Aguennouz, Mhammed, Fidani, Liana, Spanaki &, Cleanthe, Tucci, Arianna, Miquel, Raspall-Chaure, Michael, Chez, Anne, Tsai, Emily, Fassi, Marwan, Shinawi, John N, Constantino, Rita, De Zorzi, Sara, Fortuna, Fernando, Kok, Boris, Keren, Dominique, Bonneau, Murim, Choi, Bruria, Benzeev, Federico, Zara, Heather C, Mefford, Ingrid E, Scheffer, Jill, Clayton-Smith, Alfons, Macaya, James E, Rothman, Evan E, Eichler, Dimitri M, Kullmann, Henry, Houlden, Salvatore Rossi, Gabriella Silvestri (ORCID:0000-0002-1950-1468), Vincenzo, Salpietro, Christine L, Dixon, Hui, Guo, Oscar D, Bello, Jana, Vandrovcova, Stephanie, Efthymiou, Reza, Maroofian, Gali, Heimer, Lydie, Burglen, Stephanie, Valence, Erin, Torti, Moritz, Hacke, Julia, Rankin, Huma, Tariq, Estelle, Colin, Vincent, Procaccio, Pasquale, Striano, Kshitij, Mankad, Andreas, Lieb, Sharon, Chen, Laura, Pisani, Conceicao, Bettencourt, Roope, Männikkö, Andreea, Manole, Alfredo, Brusco, Enrico, Grosso, Giovanni Battista, Ferrero, Judith, Armstrong-Moron, Sophie, Gueden, Omer, Bar-Yosef, Michal, Tzadok, Kristin G, Monaghan, Teresa, Santiago-Sim, Richard E, Person, Megan T, Cho, Rebecca, Willaert, Yongjin, Yoo, Jong-Hee, Chae, Yingting, Quan, Huidan, Wu, Tianyun, Wang, Raphael A, Bernier, Kun, Xia, Alyssa, Blesson, Mahim, Jain, Mohammad M, Motazacker, Bregje, Jaeger, Amy L, Schneider, Katja, Boysen, Alison M, Muir, Candace T, Myer, Ralitza H, Gavrilova, Lauren, Gunderson, Laura, Schultz-Roger, Eric W, Klee, David, Dyment, Matthew, Osmond, Mara, Parellada, Cloe, Llorente, Javier, Gonzalez-Peña, Angel, Carracedo, Arie, Van Haeringen, Claudia, Ruivenkamp, Caroline, Nava, Delphine, Heron, Rosaria, Nardello, Michele, Iacomino, Carlo, Minetti, Aldo, Skabar, Antonella, Fabretto, Hanna, Michael G., Bugiardini, Enrico, Hostettler, Isabel, O’Callaghan, Benjamin, Khan, Alaa, Cortese, Andrea, O’Connor, Emer, Yau, Wai Y., Bourinaris, Thoma, Kaiyrzhanov, Rauan, Chelban, Viorica, Madej, Monika, Diana, Maria C., Vari, Maria S., Pedemonte, Marina, Bruno, Claudio, Balagura, Ganna, Scala, Marcello, Fiorillo, Chiara, Nobili, Lino, Malintan, Nancy T., Zanetti, Maria N., Krishnakumar, Shyam S., Lignani, Gabriele, Jepson, James E. C., Broda, Paolo, Baldassari, Simona, Rossi, Pia, Fruscione, Floriana, Madia, Francesca, Traverso, Monica, De-Marco, Patrizia, Pérez-Dueñas, Belen, Munell, Francina, Kriouile, Yamna, El-Khorassani, Mohamed, Karashova, Blagovesta, Avdjieva, Daniela, Kathom, Hadil, Tincheva, Radka, Van-Maldergem, Lionel, Nachbauer, Wolfgang, Boesch, Sylvia, Gagliano, Antonella, Amadori, Elisabetta, Goraya, Jatinder S., Sultan, Tipu, Kirmani, Salman, Ibrahim, Shahnaz, Jan, Farida, Mine, Jun, Banu, Selina, Veggiotti, Pierangelo, Zuccotti, Gian V., Ferrari, Michel D., Van Den Maagdenberg, Arn M. J., Verrotti, Alberto, Marseglia, Gian L., Savasta, Salvatore, Soler, Miguel A., Scuderi, Carmela, Borgione, Eugenia, Chimenz, Roberto, Gitto, Eloisa, Dipasquale, Valeria, Sallemi, Alessia, Fusco, Monica, Cuppari, Caterina, Cutrupi, Maria C., Ruggieri, Martino, Cama, Armando, Capra, Valeria, Mencacci, Niccolò E., Boles, Richard, Gupta, Neerja, Kabra, Madhulika, Papacostas, Savva, Zamba-Papanicolaou, Eleni, Dardiotis, Efthymio, Maqbool, Shazia, Rana, Nuzhat, Atawneh, Osama, Lim, Shen Y., Shaikh, Farooq, Koutsis, George, Breza, Marianthi, Coviello, Domenico A., Dauvilliers, Yves A., Alkhawaja, Issam, Alkhawaja, Mariam, Al-Mutairi, Fuad, Stojkovic, Tanya, Ferrucci, Veronica, Zollo, Massimo, Alkuraya, Fowzan S., Kinali, Maria, Sherifa, Hamed, Benrhouma, Hanene, Turki, Ilhem B. Y., Tazir, Meriem, Obeid, Makram, Bakhtadze, Sophia, Saadi, Nebal W., Zaki, Maha S., Triki, Chahnez C., Benfenati, Fabio, Gustincich, Stefano, Kara, Majdi, Belcastro, Vincenzo, Specchio, Nicola, Capovilla, Giuseppe, Karimiani, Ehsan G., Salih, Ahmed M., Okubadejo, Njideka U., Ojo, Oluwadamilola O., Oshinaike, Olajumoke O., Oguntunde, Olapeju, Wahab, Kolawole, Bello, Abiodun H., Abubakar, Sanni, Obiabo, Yahaya, Nwazor, Ernest, Ekenze, Oluchi, Williams, Uduak, Iyagba, Alagoma, Taiwo, Lolade, Komolafe, Morenikeji, Senkevich, Konstantin, Shashkin, Chingiz, Zharkynbekova, Nazira, Koneyev, Kairgali, Manizha, Ganieva, Isrofilov, Maksud, Guliyeva, Ulviyya, Salayev, Kamran, Khachatryan, Samson, Rossi, Salvatore, Silvestri, Gabriella, Haridy, Nourelhoda, Ramenghi, Luca A., Xiromerisiou, Georgia, David, Emanuele, Aguennouz, Mhammed, Fidani, Liana, Spanaki &, Cleanthe, Tucci, Arianna, Miquel, Raspall-Chaure, Michael, Chez, Anne, Tsai, Emily, Fassi, Marwan, Shinawi, John N, Constantino, Rita, De Zorzi, Sara, Fortuna, Fernando, Kok, Boris, Keren, Dominique, Bonneau, Murim, Choi, Bruria, Benzeev, Federico, Zara, Heather C, Mefford, Ingrid E, Scheffer, Jill, Clayton-Smith, Alfons, Macaya, James E, Rothman, Evan E, Eichler, Dimitri M, Kullmann, Henry, Houlden, Salvatore Rossi, and Gabriella Silvestri (ORCID:0000-0002-1950-1468)
- Abstract
AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at the Q607 site, it renders heteromultimeric AMPARs Ca2+-impermeable, with a linear relationship between current and trans-membrane voltage. Here, we report heterozygous de novo GRIA2 mutations in 28 unrelated patients with intellectual disability (ID) and neurodevelopmental abnormalities including autism spectrum disorder (ASD), Rett syndrome-like features, and seizures or developmental epileptic encephalopathy (DEE). In functional expression studies, mutations lead to a decrease in agonist-evoked current mediated by mutant subunits compared to wild-type channels. When GluA2 subunits are co-expressed with GluA1, most GRIA2 mutations cause a decreased current amplitude and some also affect voltage rectification. Our results show that de-novo variants in GRIA2 can cause neurodevelopmental disorders, complementing evidence that other genetic causes of ID, ASD and DEE also disrupt glutamatergic synaptic transmission.
- Published
- 2019
34. PRUNE-1 DRIVES THE RECRUITMENT AND THE POLARIZATION OF TUMOUR-ASSOCIATED MACROPHAGES (TAMS) PREPARING THE SOIL FOR LUNG METASTASES IN TRIPLE NEGATIVE BREAST CANCER
- Author
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FERRUCCI, VERONICA
- Abstract
Tumour microenvironment is a complex network of cells, including immune cells, with a role in tumorigenesis and metastatic spread. Among the immune cells, M2-polarized Tumour-Associated-Macrophages (M2-TAMs) show immunosuppressive activities by expressing inflammatory molecules, thus promoting tumorigenesis. Triple-Negative Breast Cancer (TNBC), lacking both hormone receptors (i.e. Progesterone Receptor [PgR] and Estrogen Receptor [ER]) and Human Epidermal growth factor Receptor 2 (HER2), is associated with poor prognosis and high probability of distant metastases. In TNBC, a large number of infiltrating M2-TAMs is positively correlated to higher risk of metastases and lower rates of Disease-Free Survival? (EFS) and Overall Survival (OS). Prune-1 belongs to DHH (Asp-His-His) phosphoesterase superfamily with an exopolyphosphatase activity. The overexpression of Prune-1 is correlated with metastases and poor prognosis in several tumours including Breast Cancer (BC). Prune-1 was also found to induce Epithelial-Mesenchimal-Transition (EMT) and metastatic dissemination throught the enhancement of canonical TGF-? signaling by counterbalancing its inhibition operated by NDPK-A. Further evidences suggested that lung cancer progression is driven by Prune-1 through the canonical WNT signaling pathway in both autocrine and paracrine manner via Wnt3a cytokine secretion, thus suggesting a potential role for Prune-1 also in extracellular environment. Here, we identified Prune-1 protein as overexpressed in TNBC patients and positively correlated to lynphnode metastases, inflammatory pathways and infiltrating M2-TAMs (CD68+/CD163+). Furthermore, we developed a Genetically Engineered Mouse Model (GEMM) of metastatic TNBC over-expressing both Prune-1 and Wnt-1 in mammary glands (MMTV-Prune1/Wnt1). We found Prune-1 to recruit TAMs and to enhance their polarization toward a pro-tumorigenic M2-phenotype in the tumour microenvironment, thus promoting lung metastases in this GEMM. We also show that Prune-1 takes part to the communication between TNBC cells and TAMs through intracellular pathways activation (i.e., TGF-b and NF-kB), but also in a paracrine manner by inducing the secretion of inflammatory cytokines (e.g., IL-17F and IL-28) and modulating the exosome protein contents. Finally, we found an anti-Prune-1 drug (AA7.1) with the ability to reduce the primary tumour growth by reducing the percentage of M2-TAMs in orthotopic xenograft immunocompetent models of TNBC. In conclusion, our GEMM of metastatic TNBC driven by Prune-1 will be a useful source for future immunotherapy pre-clinical trials targeting M2-polarized TAMs within the tumour microenvironment to inhibit distant metastases in TNBC with poor prognosis.
- Published
- 2018
- Full Text
- View/download PDF
35. Targeting PRUNE-1 in a GEMM of Metastatic Medulloblastoma : A Potential Route of Inhibition for New Future Therapies
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Ferrucci, Veronica, de Antonellis, Pasqualino, Pennino, Francesco Paolo, Asadzadeh, Fatemeh, Siciliano, Roberto, Virgilio, Antonella, Galeone, Aldo, De Martino, Lucia, Quaglietta, Lucia, Errico, Maria Elena, Donofrio, Vittoria, Picard, Daniel, Remke, Marc, Chesler, Louis, Johansson, Fredrik K., Weiss, William, Taylor, Michael, Cinalli, Giuseppe, Zollo, Massimo, Ferrucci, Veronica, de Antonellis, Pasqualino, Pennino, Francesco Paolo, Asadzadeh, Fatemeh, Siciliano, Roberto, Virgilio, Antonella, Galeone, Aldo, De Martino, Lucia, Quaglietta, Lucia, Errico, Maria Elena, Donofrio, Vittoria, Picard, Daniel, Remke, Marc, Chesler, Louis, Johansson, Fredrik K., Weiss, William, Taylor, Michael, Cinalli, Giuseppe, and Zollo, Massimo
- Published
- 2018
- Full Text
- View/download PDF
36. Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1–TGF-β–OTX2–SNAIL via PTEN inhibitio
- Author
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Ferrucci, Veronica, de Antonellis, Pasqualino, Pennino, Francesco Paolo, Asadzadeh, Fatemeh, Virgilio, Antonella, Montanaro, Donatella, Galeone, Aldo, Boffa, Iolanda, Pisano, Ida, Scognamiglio, Iolanda, Navas, Luigi, Diana, Donatella, Pedone, Emilia, Gargiulo, Sara, Gramanzini, Matteo, Brunetti, Arturo, Danielson, Laura, Carotenuto, Marianeve, Liguori, Lucia, Verrico, Antonio, Quaglietta, Lucia, Errico, Maria Elena, Del Monaco, Valentina, D'Argenio, Valeria, Tirone, Felice, Mastronuzzi, Angela, Donofrio, Vittoria, Giangaspero, Felice, Picard, Daniel, Remke, Marc, Garzia, Livia, Daniels, Craig, Delattre, Olivier, Johansson, Fredrik K., Weiss, William A., Salvatore, Francesco, Fattorusso, Roberto, Chesler, Louis, Taylor, Michael D., Cinalli, Giuseppe, Zollo, Massimo, Ferrucci, Veronica, de Antonellis, Pasqualino, Pennino, Francesco Paolo, Asadzadeh, Fatemeh, Virgilio, Antonella, Montanaro, Donatella, Galeone, Aldo, Boffa, Iolanda, Pisano, Ida, Scognamiglio, Iolanda, Navas, Luigi, Diana, Donatella, Pedone, Emilia, Gargiulo, Sara, Gramanzini, Matteo, Brunetti, Arturo, Danielson, Laura, Carotenuto, Marianeve, Liguori, Lucia, Verrico, Antonio, Quaglietta, Lucia, Errico, Maria Elena, Del Monaco, Valentina, D'Argenio, Valeria, Tirone, Felice, Mastronuzzi, Angela, Donofrio, Vittoria, Giangaspero, Felice, Picard, Daniel, Remke, Marc, Garzia, Livia, Daniels, Craig, Delattre, Olivier, Johansson, Fredrik K., Weiss, William A., Salvatore, Francesco, Fattorusso, Roberto, Chesler, Louis, Taylor, Michael D., Cinalli, Giuseppe, and Zollo, Massimo
- Abstract
Genetic modifications during development of paediatric groups 3 and 4 medulloblastoma are responsible for their highly metastatic properties and poor patient survival rates. PRUNE1 is highly expressed in metastatic medulloblastoma group 3, which is characterized by TGF-β signalling activation, c-MYC amplification, and OTX2 expression. We describe the process of activation of the PRUNE1 signalling pathway that includes its binding to NME1, TGF-β activation, OTX2 upregulation, SNAIL (SNAI1) upregulation, and PTEN inhibition. The newly identified small molecule pyrimido-pyrimidine derivative AA7.1 enhances PRUNE1 degradation, inhibits this activation network, and augments PTEN expression. Both AA7.1 and a competitive permeable peptide that impairs PRUNE1/NME1 complex formation, impair tumour growth and metastatic dissemination in orthotopic xenograft models with a metastatic medulloblastoma group 3 cell line (D425-Med cells). Using whole exome sequencing technology in metastatic medulloblastoma primary tumour cells, we also define 23 common ‘non-synonymous homozygous’ deleterious gene variants as part of the protein molecular network of relevance for metastatic processes. This PRUNE1/TGF-β/OTX2/PTEN axis, together with the medulloblastoma-driver mutations, is of relevance for future rational and targeted therapies for metastatic medulloblastoma group 3.
- Published
- 2018
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- View/download PDF
37. MBRS-52. TARGETING PRUNE-1 IN A GEMM OF METASTATIC MEDULLOBLASTOMA: A POTENTIAL ROUTE OF INHIBITION FOR NEW FUTURE THERAPIES
- Author
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Ferrucci, Veronica, primary, de Antonellis, Pasqualino, additional, Pennino, Francesco Paolo, additional, Asadzadeh, Fatemeh, additional, Siciliano, Roberto, additional, Virgilio, Antonella, additional, Galeone, Aldo, additional, De Martino, Lucia, additional, Quaglietta, Lucia, additional, Errico, Maria Elena, additional, Donofrio, Vittoria, additional, Picard, Daniel, additional, Remke, Marc, additional, Chesler, Louis, additional, Swartling, Fredrik, additional, Weiss, William, additional, Taylor, Michael, additional, Cinalli, Giuseppe, additional, and Zollo, Massimo, additional
- Published
- 2018
- Full Text
- View/download PDF
38. Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1–TGF-β–OTX2–SNAIL via PTEN inhibition
- Author
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Ferrucci, Veronica, primary, de Antonellis, Pasqualino, additional, Pennino, Francesco Paolo, additional, Asadzadeh, Fatemeh, additional, Virgilio, Antonella, additional, Montanaro, Donatella, additional, Galeone, Aldo, additional, Boffa, Iolanda, additional, Pisano, Ida, additional, Scognamiglio, Iolanda, additional, Navas, Luigi, additional, Diana, Donatella, additional, Pedone, Emilia, additional, Gargiulo, Sara, additional, Gramanzini, Matteo, additional, Brunetti, Arturo, additional, Danielson, Laura, additional, Carotenuto, Marianeve, additional, Liguori, Lucia, additional, Verrico, Antonio, additional, Quaglietta, Lucia, additional, Errico, Maria Elena, additional, Del Monaco, Valentina, additional, D’Argenio, Valeria, additional, Tirone, Felice, additional, Mastronuzzi, Angela, additional, Donofrio, Vittoria, additional, Giangaspero, Felice, additional, Picard, Daniel, additional, Remke, Marc, additional, Garzia, Livia, additional, Daniels, Craig, additional, Delattre, Olivier, additional, Swartling, Fredrik J, additional, Weiss, William A, additional, Salvatore, Francesco, additional, Fattorusso, Roberto, additional, Chesler, Louis, additional, Taylor, Michael D, additional, Cinalli, Giuseppe, additional, and Zollo, Massimo, additional
- Published
- 2018
- Full Text
- View/download PDF
39. Immunotherapy Bridge 2017 and Melanoma Bridge 2017: meeting abstracts
- Author
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Carbone, David, primary, Sharpnack, Michael, additional, He, Kai, additional, Butterfield, Lisa H., additional, Eggermont, Alexander M. M., additional, Gonzalez-Cao, Maria, additional, Karachaliou, Niki, additional, Crespo, Guillermo, additional, Aldeguer, Erika, additional, Drozdowskyj, Ana, additional, Giménez-Capitán, Ana, additional, Teixidó, Cristina, additional, Molina-Vila, Miguel Angel, additional, Ramírez, Santiago Viteri, additional, Algarra, Salvador Martin, additional, Pérez-Ruiz, Elisabeth, additional, Márquez-Rodas, Iván, additional, Rodriguez-Abreu, Delvys, additional, Blanco, Remei, additional, Puértolas, Teresa, additional, Royo, Maria Angeles, additional, Rosell, Rafael, additional, Ascierto, Maria Libera, additional, Hamm, Svetlana, additional, Wulff, Tanja, additional, Kronthaler, Kerstin, additional, Schrepfer, Sabine, additional, Parnitzke, Ulrike, additional, Bretz, Anne Catherine, additional, Baumgartner, Roland, additional, Ferrucci, Veronica, additional, Pennino, Francesco Paolo, additional, Dassi, Luisa, additional, Asadzadeh, Fatemeh, additional, Siciliano, Roberto, additional, Carotenuto, Marianeve, additional, Spano, Daniela, additional, Chiarolla, Cristina Maria, additional, Greco, Adelaide, additional, Cantile, Monica, additional, Di Bonito, Maurizio, additional, Botti, Gerardo, additional, Jonathan, Vandenbussche, additional, Kris, Gevaert, additional, Zollo, Massimo, additional, Amaral, Teresa, additional, Tampouri, Ioanna, additional, Keim, Ulrike, additional, Eigentler, Thomas, additional, Garbe, Claus, additional, Forschner, Andrea, additional, Cesano, Alessandra, additional, Warren, Sarah, additional, Moogk, Duane, additional, Li, Kaitao, additional, Yuan, Zhou, additional, Zhong, Shi, additional, Yu, Zhiya, additional, Liadi, Ivan, additional, Rittase, William, additional, Fang, Victoria, additional, Dougherty, Janna, additional, Perez-Garcia, Arianne, additional, Osman, Iman, additional, Varadarajan, Navin, additional, Restifo, Nicholas P., additional, Frey, Alan, additional, Zhu, Cheng, additional, Krogsgaard, Michelle, additional, Vanpouille-Box, Claire, additional, Formenti, Silvia C., additional, Demaria, Sandra, additional, Nigro, Cristiana Lo, additional, Renziehausen, Alexander, additional, Tzakos, Andreas G., additional, Wang, Hexiao, additional, Rao, Bhavya, additional, Matin, Rubeta, additional, Harwood, Catherine, additional, Vivenza, Daniela, additional, Tonissi, Federica, additional, Occelli, Marcella, additional, Weir, Lynda, additional, Li, Su, additional, Sim, Van Ren, additional, O’Neill, Kevin, additional, Evans, Alan, additional, Thompson, Alastair, additional, Szlosarek, Peter, additional, Fleming, Colin, additional, Proby, Charlotte, additional, Syed, Nelofer, additional, Merlano, Marco, additional, Crook, Tim, additional, Ferguson, Robert, additional, Simpson, Danny, additional, Martinez, Carlos, additional, Vogelsang, Matjaz, additional, Kazlow, Esther, additional, Wilson, Melissa, additional, Pavlick, Anna, additional, Weber, Jeffrey, additional, Sullivan, Ryan, additional, Flaherty, Keith, additional, Ribas, Antoni, additional, Kirchhoff, Tomas, additional, D’Avino, Antonio, additional, Guida, Licia, additional, Cosacco, Augusto, additional, D’Aniello, Roberta, additional, Maiolino, Piera, additional, Tramontano, Teresa, additional, Sarno, Maria R., additional, Palazzo, Ida, additional, Di Napoli, Angela, additional, Acunzo, Gianclaudio, additional, De Fina, Mariarosanna, additional, Silvestri, Antonia, additional, Specchia, Monica, additional, Musacchio, Michela, additional, Giglio, Gianfranco, additional, Carrozza, Francesco, additional, Di Lullo, Liberato, additional, De Maddi, Gian Marco, additional, Venturelli, Adele, additional, Gambale, Elisabetta, additional, Gatta, Alessia, additional, Brocco, Davide, additional, Carella, Consiglia, additional, De Tursi, Michele, additional, Gajewski, Thomas F., additional, Cristiani, Costanza M., additional, Tallerico, Rossana, additional, Ventura, Valeria, additional, Capone, Mariaelena, additional, Madonna, Gabriele, additional, Mallardo, Domenico, additional, Selinger, Eliska, additional, Garofalo, Cinzia, additional, Staaf, Elina, additional, Simeone, Ester, additional, Grimaldi, Antonio M., additional, del Zotto, Genny, additional, Gulletta, Elio, additional, Ciliberto, Gennaro, additional, Moretta, Alessandro, additional, Ascierto, Paolo A., additional, Carbone, Ennio, additional, Costantini, Susan, additional, Sorice, Angela, additional, Capone, Francesca, additional, Budillon, Alfredo, additional, Cauchi, Carolina, additional, Sciancalepore, Grazia, additional, Rovera, Michela, additional, Varamo, Chiara, additional, Seia, Zelda, additional, Palazzini, Stefania, additional, Errico, Fabiana, additional, Basso, Davide, additional, Quaranta, Laura, additional, Forte, Giuseppe, additional, Lavagna, Fulvio, additional, Violante, Silvia, additional, Bosio, Paolo, additional, Lattanzio, Laura, additional, Merlano, Marco C, additional, Gowen, Mike, additional, Tchack, Jeremy, additional, Zhou, Hua, additional, Giles, Keith, additional, Paschke, Scott, additional, Moran, Una, additional, Fenyo, David, additional, Tsirigos, Aris, additional, Pacold, Michael, additional, Morello, Silvana, additional, Sorrentino, Claudia, additional, Giannarelli, Diana, additional, Pinto, Aldo, additional, Fratangelo, Federica, additional, Falcone, Rosaria, additional, Vanella, Vito, additional, Schadendorf, Dirk, additional, Lewis, Karl, additional, Maio, Michele, additional, Demidov, Lev, additional, Mandalà, Mario, additional, Bondarenko, Igor, additional, Herbert, Christopher, additional, Mackiewicz, Andrzej, additional, Rutkowski, Piotr, additional, Guminski, Alexander, additional, Goodman, Grant, additional, Simmons, Brian, additional, Ye, Chenglin, additional, Hooper, Gregory, additional, Wongchenko, Matthew J., additional, Yan, Yibing, additional, Hermann, Frank, additional, Ammendola, Astrid, additional, Bartz, René, additional, Alessandra, Bulotta, additional, Letizia, Colombo, additional, Aurora, Mirabile, additional, Chiara, Lazzari, additional, Raffaele, Mercuri Santo, additional, Danilo, Parolini, additional, Nathalie, Rizzo, additional, Stefano, Martella, additional, Giulio, Modorati, additional, Pina, Brianti, additional, Enza, Cestone, additional, Federica, Bellinzona, additional, Elisabetta, Miserocchi, additional, Luca, Gianni, additional, Vanesa, Gregorc, additional, Agarwala, Sanjiv, additional, Mark Smithers, B., additional, Haushild, Axel, additional, Watcher, Eric, additional, Fattore, Luigi, additional, Ruggiero, Ciro Francesco, additional, Liguoro, Domenico, additional, Cerri, Andrea, additional, Pisanu, Maria Elena, additional, and Mancini, Rita, additional
- Published
- 2018
- Full Text
- View/download PDF
40. PRUNE is crucial for normal brain development and mutated in microcephaly with neurodevelopmental impairment
- Author
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Zollo, Massimo, primary, Ahmed, Mustafa, additional, Ferrucci, Veronica, additional, Salpietro, Vincenzo, additional, Asadzadeh, Fatemeh, additional, Carotenuto, Marianeve, additional, Maroofian, Reza, additional, Al-Amri, Ahmed, additional, Singh, Royana, additional, Scognamiglio, Iolanda, additional, Mojarrad, Majid, additional, Musella, Luca, additional, Duilio, Angela, additional, Di Somma, Angela, additional, Karaca, Ender, additional, Rajab, Anna, additional, Al-Khayat, Aisha, additional, Mohan Mohapatra, Tribhuvan, additional, Eslahi, Atieh, additional, Ashrafzadeh, Farah, additional, Rawlins, Lettie E., additional, Prasad, Rajniti, additional, Gupta, Rashmi, additional, Kumari, Preeti, additional, Srivastava, Mona, additional, Cozzolino, Flora, additional, Kumar Rai, Sunil, additional, Monti, Maria, additional, Harlalka, Gaurav V., additional, Simpson, Michael A., additional, Rich, Philip, additional, Al-Salmi, Fatema, additional, Patton, Michael A., additional, Chioza, Barry A., additional, Efthymiou, Stephanie, additional, Granata, Francesca, additional, Di Rosa, Gabriella, additional, Wiethoff, Sarah, additional, Borgione, Eugenia, additional, Scuderi, Carmela, additional, Mankad, Kshitij, additional, Hanna, Michael G., additional, Pucci, Piero, additional, Houlden, Henry, additional, Lupski, James R., additional, Crosby, Andrew H., additional, and Baple, Emma L., additional
- Published
- 2017
- Full Text
- View/download PDF
41. In vivo bioluminescence imaging using orthotopic xenografts towards patient's derived-xenograft Medulloblastoma models
- Author
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Asadzadeh, Fatemeh, primary, Ferrucci, Veronica, additional, De Antonellis, Pasqualino, additional, and Zollo, Massimo, additional
- Published
- 2017
- Full Text
- View/download PDF
42. Glioblastoma stem cells differentiation through epigenetic modulation is driven by miR-296-5p/HMGA1/Sox2 axis
- Author
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Ferrucci, Veronica, primary and Zollo, Massimo, additional
- Published
- 2016
- Full Text
- View/download PDF
43. Natural compounds for pediatric cancer treatment
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Ferrucci, Veronica, primary, Boffa, Iolanda, additional, De Masi, Gina, additional, and Zollo, Massimo, additional
- Published
- 2015
- Full Text
- View/download PDF
44. The phenotypic and molecular spectrum of PEHO syndrome and PEHO-like disorders.
- Author
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Salpietro, Vincenzo, Zollo, Massimo, Vandrovcova, Jana, Ryten, Mina, Botia, Juan A., Ferrucci, Veronica, Manole, Andreea, Efthymiou, Stephanie, Al Mutairi, Fuad, Bertini, Enrico, Tartaglia, Marco, Houlden, Henry, and SYNAPS Study Group
- Subjects
NEURODEGENERATION ,PHENOTYPES ,CEREBRAL edema ,NEURONS ,OPTIC nerve diseases ,INFANTILE spasms - Published
- 2017
- Full Text
- View/download PDF
45. Early Targets of miR-34a in Neuroblastoma
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De Antonellis, Pasqualino, primary, Carotenuto, Marianeve, additional, Vandenbussche, Jonathan, additional, De Vita, Gennaro, additional, Ferrucci, Veronica, additional, Medaglia, Chiara, additional, Boffa, Iolanda, additional, Galiero, Alessandra, additional, Di Somma, Sarah, additional, Magliulo, Daniela, additional, Aiese, Nadia, additional, Alonzi, Alessandro, additional, Spano, Daniela, additional, Liguori, Lucia, additional, Chiarolla, Cristina, additional, Verrico, Antonio, additional, Schulte, Johannes H., additional, Mestdagh, Pieter, additional, Vandesompele, Jo, additional, Gevaert, Kris, additional, and Zollo, Massimo, additional
- Published
- 2014
- Full Text
- View/download PDF
46. MicroRNA 199b-5p delivery through stable nucleic acid lipid particles (SNALPs) in tumorigenic cell lines.
- Author
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Antonellis, Pasqualino, Liguori, Lucia, Falanga, Annarita, Carotenuto, Marianeve, Ferrucci, Veronica, Andolfo, Immacolata, Marinaro, Federica, Scognamiglio, Immacolata, Virgilio, Antonella, Rosa, Giuseppe, Galeone, Aldo, Galdiero, Stefania, and Zollo, Massimo
- Abstract
MicroRNA (miR)-199b-5p has been shown to regulate Hes-1, a downstream effector of the canonical Notch and noncanonical SHH pathways, whereby it impairs medulloblastoma (MB) cancer stem cells (CSCs) through a decrease in the CD133+/CD15+ cell population. Here, we have developed stable nucleic acid lipid particles (SNALPs) that encapsulate miR-199b-5p. The efficacy of the miR-199b-5p delivery by these SNALPs is demonstrated by significant impairment of Hes-1 levels and CSC markers in a range of different tumorigenic cell lines: colon (HT-29, CaCo-2, and SW480), breast (MDA-MB231T and MCF-7), prostate (PC-3), glioblastoma (U-87), and MB (Daoy, ONS-76, and UW-228). After treatment with SNALP miR-199b-5p, there is also impairment of cell proliferation and no signs of apoptosis, as measured by caspases 3/7 activity and annexin V fluorescence cell sorter analyses. These data strengthen the importance of such carriers for miRNA delivery, which show no cytotoxic effects and provide optimal uptake into cells. Thus, efficient target downregulation in different tumorigenic cell lines will be the basis for future preclinical studies. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
47. A Novel Human Neutralizing mAb Recognizes Delta, Gamma and Omicron Variants of SARS-CoV-2 and Can Be Used in Combination with Sotrovimab
- Author
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Margherita Passariello, Veronica Ferrucci, Emanuele Sasso, Lorenzo Manna, Rosa Rapuano Lembo, Stefano Pascarella, Giovanna Fusco, Nicola Zambrano, Massimo Zollo, Claudia De Lorenzo, Passariello, Margherita, Ferrucci, Veronica, Sasso, Emanuele, Manna, Lorenzo, Lembo, Rosa Rapuano, Pascarella, Stefano, Fusco, Giovanna, Zambrano, Nicola, Zollo, Massimo, and De Lorenzo, Claudia
- Subjects
combinatorial treatment ,Antibodies, Monoclonal, Humanized ,Antibodies, Viral ,Catalysis ,neutralizing mAb ,combinatorial treatments ,Inorganic Chemistry ,Epitopes ,Viral Envelope Proteins ,Humans ,Physical and Theoretical Chemistry ,Molecular Biology ,Spectroscopy ,SARS-CoV-2 ,Organic Chemistry ,COVID-19 ,Antibodies, Monoclonal ,Viral Envelope Protein ,General Medicine ,Omicron variant ,neutralizing mAbs ,Spike-RBD/ACE-2 ,Antibodies, Neutralizing ,Computer Science Applications ,COVID-19 Drug Treatment ,Spike Glycoprotein, Coronavirus ,Epitope ,Spike Glycoprotein, Coronaviru ,Human - Abstract
The dramatic experience with SARS-CoV-2 has alerted the scientific community to be ready to face new epidemics/pandemics caused by new variants. Among the therapies against the pandemic SARS-CoV-2 virus, monoclonal Antibodies (mAbs) targeting the Spike glycoprotein have represented good drugs to interfere in the Spike/ Angiotensin Converting Enzyme-2 (ACE-2) interaction, preventing virus cell entry and subsequent infection, especially in patients with a defective immune system. We obtained, by an innovative phage display selection strategy, specific binders recognizing different epitopes of Spike. The novel human antibodies specifically bind to Spike-Receptor Binding Domain (RBD) in a nanomolar range and interfere in the interaction of Spike with the ACE-2 receptor. We report here that one of these mAbs, named D3, shows neutralizing activity for virus infection in cell cultures by different SARS-CoV-2 variants and retains the ability to recognize the Omicron-derived recombinant RBD differently from the antibodies Casirivimab or Imdevimab. Since anti-Spike mAbs, used individually, might be unable to block the virus cell entry especially in the case of resistant variants, we investigated the possibility to combine D3 with the antibody in clinical use Sotrovimab, and we found that they recognize distinct epitopes and show additive inhibitory effects on the interaction of Omicron-RBD with ACE-2 receptor. Thus, we propose to exploit these mAbs in combinatorial treatments to enhance their potential for both diagnostic and therapeutic applications in the current and future pandemic waves of coronavirus.
- Published
- 2022
48. SARS-CoV-2 pandemic tracing in Italy highlights lineages with mutational burden in growing subsets
- Author
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Angelo Boccia, Rossella Tufano, Veronica Ferrucci, Leandra Sepe, Martina Bianchi, Stefano Pascarella, Massimo Zollo, Giovanni Paolella, Boccia, Angelo, Tufano, Rossella, Ferrucci, Veronica, Sepe, Leandra, Bianchi, Martina, Pascarella, Stefano, Zollo, Massimo, and Paolella, Giovanni
- Subjects
SARS-CoV-2 ,viruses ,Organic Chemistry ,variant of concern (VOC) ,viral variants tracin ,COVID-19 ,General Medicine ,Catalysis ,Computer Science Applications ,viral variants tracing ,Inorganic Chemistry ,Mutation ,Spike Glycoprotein, Coronavirus ,Humans ,Physical and Theoretical Chemistry ,Pandemics ,Molecular Biology ,Spectroscopy - Abstract
Tracing the appearance and evolution of virus variants is essential in the management of the COVID-19 pandemic. Here, we focus on SARS-CoV-2 spread in Italian patients by using viral sequences deposited in public databases and a tracing procedure which is used to monitor the evolution of the pandemic and detect the spreading, within the infected population of emergent sub-clades with a potential positive selection. Analyses of a collection of monthly samples focused on Italy highlighted the appearance and evolution of all the main viral sub-trees emerging at the end of the first year of the pandemic. It also identified additional expanding subpopulations which spread during the second year (i.e., 2021). Three-dimensional (3D) modelling of the main amino acid changes in mutated viral proteins, including ORF1ab (nsp3, nsp4, 2’-o-ribose methyltransferase, nsp6, helicase, nsp12 [RdRp]), N, ORF3a, ORF8, and spike proteins, shows the potential of the analysed structural variations to result in epistatic modulation and positive/negative selection pressure. These analyzes will be of importance to the early identification of emerging clades, which can develop into new “variants of concern” (i.e., VOC). These analyses and settings will also help SARS-CoV-2 coronet genomic centers in other countries to trace emerging worldwide variants.
- Published
- 2022
49. Seroprevalence of SARS-CoV-2 Assessed by Four Chemiluminescence Immunoassays and One Immunocromatography Test for SARS-Cov-2
- Author
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Pellegrino Cerino, Alfonso Gallo, Biancamaria Pierri, Carlo Buonerba, Denise Di Concilio, Maria Concetta Cuomo, Lucia Vassallo, Gabriella Lo Conte, Annachiara Coppola, Antonio Pizzolante, Giovanni Boccia, Veronica Ferrucci, Luigi Atripaldi, Maria Triassi, Daniela Pacella, Michele Cennamo, Paolo Romano, Teresa Maria Sorbo, Alessandro Furno, Oriana Catapano, Aldo Contina, Giuseppe Perruolo, Maurizio D'Amora, Daniela Terracciano, Giuseppe Portella, Cerino, Pellegrino, Gallo, Alfonso, Pierri, Biancamaria, Buonerba, Carlo, Di Concilio, Denise, Cuomo, Maria Concetta, Vassallo, Lucia, Lo Conte, Gabriella, Coppola, Annachiara, Pizzolante, Antonio, Boccia, Giovanni, Ferrucci, Veronica, Atripaldi, Luigi, Triassi, Maria, Pacella, Daniela, Cennamo, Michele, Romano, Paolo, Sorbo, Teresa Maria, Furno, Alessandro, Catapano, Oriana, Contina, Aldo, Perruolo, Giuseppe, D'Amora, Maurizio, Terracciano, Daniela, and Portella, Giuseppe
- Subjects
Luminescence ,Context (language use) ,Sensitivity and Specificity ,Serology ,03 medical and health sciences ,0302 clinical medicine ,Cohen's kappa ,rapid test ,Seroepidemiologic Studies ,medicine ,Seroprevalence ,Humans ,030212 general & internal medicine ,rapid tests ,Original Research ,030304 developmental biology ,Immunoassay ,0303 health sciences ,medicine.diagnostic_test ,biology ,seroprevalence ,business.industry ,SARS-CoV-2 ,Public Health, Environmental and Occupational Health ,Seroprevalence of SARS-CoV-2 ,COVID-19 ,Virology ,immunoassays ,serological test ,Immunoglobulin M ,Italy ,biology.protein ,Public Health ,Antibody ,Public aspects of medicine ,RA1-1270 ,business - Abstract
The onset of the new SARS-CoV-2 coronavirus encouraged the development of new serologic tests that could be additional and complementary to real-time RT-PCR-based assays. In such a context, the study of performances of available tests is urgently needed, as their use has just been initiated for seroprevalence assessment. The aim of this study was to compare four chemiluminescence immunoassays and one immunochromatography test for SARS-Cov-2 antibodies for the evaluation of the degree of diffusion of SARS-CoV-2 infection in Salerno Province (Campania Region, Italy). A total of 3,185 specimens from citizens were tested for anti-SARS-CoV-2 antibodies as part of a screening program. Four automated immunoassays (Abbott and Liaison SARS-CoV-2 CLIA IgG and Roche and Siemens SARS-CoV-2 CLIA IgM/IgG/IgA assays) and one lateral flow immunoassay (LFIA Technogenetics IgG–IgM COVID-19) were used. Seroprevalence in the entire cohort was 2.41, 2.10, 1.82, and 1.85% according to the Liaison IgG, Abbott IgG, Siemens, and Roche total Ig tests, respectively. When we explored the agreement among the rapid tests and the serologic assays, we reported good agreement for Abbott, Siemens, and Roche (Cohen's Kappa coefficient 0.69, 0.67, and 0.67, respectively), whereas we found moderate agreement for Liaison (Cohen's kappa coefficient 0.58). Our study showed that Abbott and Liaison SARS-CoV-2 CLIA IgG, Roche and Siemens SARS-CoV-2 CLIA IgM/IgG/IgA assays, and LFIA Technogenetics IgG-IgM COVID-19 have good agreement in seroprevalence assessment. In addition, our findings indicate that the prevalence of IgG and total Ig antibodies against SARS-CoV-2 at the time of the study was as low as around 3%, likely explaining the amplitude of the current second wave.
- Published
- 2021
- Full Text
- View/download PDF
50. SARS-CoV-2 Subgenomic N (sgN) Transcripts in Oro-Nasopharyngeal Swabs Correlate with the Highest Viral Load, as Evaluated by Five Different Molecular Methods
- Author
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Carmela Paolillo, Felice Amato, Ettore Capoluongo, Giuseppe Castaldo, Veronica Ferrucci, Massimo Zollo, Roberto Siciliano, Fabrizio Quarantelli, Carmela Di Domenico, Barbara Izzo, Marika Comegna, Zollo, Massimo, Ferrucci, Veronica, Izzo, Barbara, Quarantelli, Fabrizio, Domenico, Carmela Di, Comegna, Marika, Paolillo, Carmela, Amato, Felice, Siciliano, Roberto, Castaldo, Giuseppe, and Capoluongo, Ettore
- Subjects
0301 basic medicine ,lcsh:R5-920 ,Serial dilution ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,SARS-CoV-2 subgenomic region ,Clinical Biochemistry ,RNA ,Biology ,SARS-CoV-2 subgenomic regions ,Virology ,Article ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,030220 oncology & carcinogenesis ,CE-IVD ,Digital polymerase chain reaction ,Viral load ,lcsh:Medicine (General) ,Gene ,Subgenomic mRNA - Abstract
The COVID-19 pandemic has forced diagnostic laboratories to focus on the early diagnostics of SARS-CoV-2. The positivity of a molecular test cannot respond to the question regarding the viral capability to replicate, spread, and give different clinical effects. Despite the fact that some targets are covered by commercially-available assays, the identification of new biomarkers is desired in order to improve the quality of the information given by these assays. Therefore, since the subgenomic transcripts (sgN and sgE) are considered markers of viral activity, we evaluated these subgenomic transcripts in relation to the genomic amplification obtained using five different commercial CE-IVD tools. Methods: Five CE-IVD kits were compared in terms of their capability to detect both synthetic SARS-CoV-2 viral constructs (spiked in TMB or PBS medium) and targets (N, E, RdRp and Orf1ab genes) in twenty COVID-19–positive patients’ swabs. The sgN and sgE were assayed by real-time RT-qPCR and digital PCR. Results: None of the diagnostic kits missed the viral target genes when they were applied to targets spiked in TMB or PBS (at dilutions ranging from 100 pg to 0.1 pg). Nevertheless, once they were applied to RNA extracted from the patients’ swabs, the superimposability ranged from 50% to 100%, regardless of the extraction procedure. The sgN RNA transcript was detected only in samples with a higher viral load (Ct ≤ 22.5), while sgE was within all of the Ct ranges. Conclusions: The five kits show variable performances depending on the assay layout. It is worthy of note that the detection of the sgN transcript is associated with a higher viral load, thus representing a new marker of early and more severe infection.
- Published
- 2021
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