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1. Impact of the SARS-CoV-2 Pandemic on Hospitalizations in an Acute Psychiatric Ward

Author: Di Lorenzo R, Reami M, Dragone D, Morgante M, Panini G, Ferri P, and Rovesti S
Subjects: psychiatric hospitalizations, covid-19 pandemic, community mental health, psychiatric involuntary treatment, Public aspects of medicine, RA1-1270
Abstract: Rosaria Di Lorenzo,1 Matteo Reami,2 Diego Dragone,1 Martina Morgante,1 Giulia Panini,1 Paola Ferri,3 Sergio Rovesti3 1Mental Health Department and Drug Abuse, AUSL-Modena, Modena, 41124, Italy; 2School of Medicine & Surgery, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, 41125, Italy; 3Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, 41125, ItalyCorrespondence: Rosaria Di Lorenzo, Tel +39-335-5410018, Email saradilorenzo1@alice.it; r.dilorenzo@ausl.mo.itBackground: The Sars-CoV-2 pandemic imposed unprecedented and drastic changes in health care organizations all over the world.Purpose: To evaluate the impact of the pandemic on hospitalizations in an acute psychiatric ward.Patients and Methods: We retrospectively identified and compared acute psychiatric hospitalizations in the Service for Psychiatric Diagnosis and Care (SPDC) of AUSL-Modena during the pre-pandemic (n = 1858) and pandemic period (n = 1095), from 01/01/2017 to 31/12/2022. Data were statistically analyzed using STATA12.Results: We collected 1858 hospitalizations in the pre-pandemic and 1095 in the pandemic. During the pandemic, we observed a progressively sharp reduction in voluntary hospitalizations, whereas involuntary ones remained stable with an increase in 2022 (p < 0.001), longer hospital stays (12.32 mean days vs 10.03; p < 0.001), longer periods of involuntary hospitalizations (8.45 mean days vs 5.72; p < 0.001), more frequent aggressive behaviour (16.10% vs 9.12%; p < 0.001) and referral to psychiatric communities at discharge (11.04% vs 6.13%; p < 0.001); non-Italians (p = 0.001), people with disability pension (p < 0.001) and Support Administrator (p < 0.001) were more frequently hospitalized.Conclusion: During the pandemic, voluntary psychiatric hospitalizations decreased, but not involuntary ones, and the most vulnerable people in serious clinical conditions were hospitalized.Keywords: psychiatric hospitalizations, COVID-19 pandemic, community mental health, psychiatric involuntary treatment
Published: 2024

2. Involuntary Hospitalizations in an Italian Acute Psychiatric Ward: A 6-Year Retrospective Analysis

Author: Di Lorenzo R, Reami M, Dragone D, Morgante M, Panini G, Rovesti S, Filippini T, Ferrari S, and Ferri P
Subjects: nonadherence to treatment, involuntary psychiatric hospitalizations, the pandemic, revolving door, Medicine (General), R5-920
Abstract: Rosaria Di Lorenzo,1 Matteo Reami,2 Diego Dragone,1 Martina Morgante,1 Giulia Panini,1 Sergio Rovesti,3 Tommaso Filippini,3,4 Silvia Ferrari,3,5 Paola Ferri3 1Mental Health Department and Drug Abuse, AUSL-Modena, Modena, Italy; 2School of Medicine & Surgery, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; 3Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; 4School of Public Health, University of California Berkeley, Berkeley, CA, USA; 5Mental Health Department and Drug Abuse, AUSL-IRCCS Reggio Emilia, Reggio Emilia, ItalyCorrespondence: Rosaria Di Lorenzo, Mental Health Department and Drug Abuse, SPDC in OCSAE, via P. Giardini, 1355, Baggiovara, Modena, 41126, Italy, Tel +393355410018, Email saradilorenzo1@alice.it; r.dilorenzo@ausl.mo.itPurpose: We evaluated the differences between demographic (age, sex, nationality, employment, housing, schooling, support administrator), clinical (hospitalization reason, aggressive behaviour, length of hospitalization, psychiatric diagnosis and comorbidities, psychiatric medications, discharge destination, “revolving door” hospitalizations) and environmental (pre-and pandemic period) variables in voluntary (VHs) and involuntary hospitalizations (IHs) in an acute psychiatric ward during a 6-year period.Patients and Methods: We retrospectively collected the selected variables concerning the hospitalizations of subjects over 18 years of age in the Service for Psychiatric Diagnosis and Care of Mental Health and Drug Abuse Department in Modena from 01/01/2017 to 31/12/2022.Results: We observed a progressive and sharp reduction in the number of VHs (n = 1800; 61.41%) during the pandemic and a stability of IHs (n = 1131; 38.59%), which in 2022 became prevalent. We highlighted the following differences between VHs and IHs: an increase in hospitalization length in IHs (14.25 mean days ± 15.89 SD) in comparison with VHs (8.78 mean days ± 13.88 SD), which increased more during the pandemic; an increase in aggressive behavior in IHs, especially during the pandemic (Pearson Chi2 = 90.80; p = 0.000); a prevalence of schizophrenia and bipolar disorders (Pearson Chi2 = 283.63; p = 0.000) and more frequent maladaptive social conditions among subjects in IHs.Conclusion: During the 6-year observation period, we underscored a trend of increasingly reduced recourse to VHs, whereas IHs increased even in the pandemic. Our results suggest that IHs in Psychiatry represented an extreme measure for treating the most severe psychopathological situations such as schizophrenia and bipolar disorders, characterized by aggressive behaviour and precarious social conditions, which needed longer stay than VHs, especially during the pandemic.Keywords: nonadherence to treatment, involuntary psychiatric hospitalizations, pandemic, revolving door
Published: 2023

3. Pain Management in a Prehospital Emergency Setting: A Retrospective Observational Study

Author: Ferri P, Gambaretto C, Alberti S, Parogni P, Rovesti S, Di Lorenzo R, Sollami A, and Bargellini A
Subjects: pain assessment, pain management, prehospital emergency care, emergency medical services, undertreatment of pain, Medicine (General), R5-920
Abstract: Paola Ferri,1 Carlo Gambaretto,2 Sara Alberti,3 Pierpaolo Parogni,2 Sergio Rovesti,1 Rosaria Di Lorenzo,4 Alfonso Sollami,5 Annalisa Bargellini1 1Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; 2Emergency Department, ASST of Mantova, Mantova, Italy; 3Clinical and Experimental Medicine PhD Program, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; 4Department of Mental Health and Drug Abuse, AUSL of Modena, Modena, Italy; 5Health Professions Service, University Hospital of Parma, Parma, ItalyCorrespondence: Sara Alberti, Clinical and Experimental Medicine PhD Program, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, 41125, Italy, Tel +390592055599, Email sara.alberti@unimore.itPurpose: Acute pain is a prevalent symptomatology in prehospital emergency care. Although inadequate assessment and treatment of acute pain are associated with various complications, about 43% of adults suffering from pain are undertreated. This phenomenon is poorly studied, and limited data are available in the literature. The objective was to investigate the pain management in a prehospital emergency health-care setting, verifying pain assessment, pharmacological treatment adherence and the effectiveness of pain relief therapy.Patients and Methods: A retrospective observational study was conducted in a sample including all adults treated by the professionals of nurse-staffed ambulances and medical cars in an Italian Emergency Medical Services (EMS) from 1 January 2019 to 31 May 2019. We collected both demographic information and Numeric Rating Scale scores, which evaluated presence and intensity of pain, from the EMS paper forms. All analyses were performed using SPSS, version 27.Results: The study sample was composed of 629 people: 310 males (49%) and 319 females (51%), with an average age of 64.2± 22 years (range 18– 108). Pain information was collected in 75.5% (n = 475) of our sample; among them 222 patients (46.7%) suffered from pain. We recorded that 79.7% (n = 177) of the subjects with pain received no pharmacological treatment, and in almost all of the treated cases they did not adhere to the analgesia algorithm in use. Among those who were pharmacologically treated, pain statistically significantly decreased in intensity, from before to after, in both emergency vehicles (nurse-staffed ambulances pre m = 8.36± 0.9 vs post m = 4.18± 2.2, p< 0.001; medical cars pre m = 7.25± 1.7 vs post m = 3.50± 2.6, p< 0.001). Subsequently, pain was only re-ascertained in 24.3% of subjects.Conclusion: Our findings confirm that pain is a prevalent symptom in prehospital patients, especially in the younger age range, but that it remains an underrecognized, underestimated, and undertreated symptom with the risk of causing worse health outcomes.Keywords: pain assessment, pain management, prehospital emergency care, emergency medical services, undertreatment of pain
Published: 2022

4. Effectiveness and Quality of Life with Paliperidone Palmitate 3-Monthly in Comparison with Other Long-Acting Drugs

Author: Di Lorenzo R, Iorio A, Pinelli M, Magarini F, Marchi M, Sacchetti A, Calogero C, Galeazzi GM, Ferri P, Rovesti S, and Minarini A
Subjects: antipsychotic long-acting injections, schizophrenia spectrum disorders, relapses, quality of life, health satisfaction, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract: Rosaria Di Lorenzo,1 Anita Iorio,2 Margherita Pinelli,3 Federica Magarini,3 Mattia Marchi,3 Andrea Sacchetti,3 Chiara Calogero,4 Gian Maria Galeazzi,5 Paola Ferri,5 Sergio Rovesti,5 Alessandro Minarini6 1Service of Psychiatric Diagnosis and Care, Department of Mental Health and Pathological Addictions, AUSL-Modena, Modena, Italy; 2Psychiatric Rehabilitation Technique Programme, University of Modena and Reggio Emilia, Reggio Emilia, Italy; 3School of Psychiatry, University of Modena and Reggio Emilia, Modena, Italy; 4Community Mental Health Center, Vignola (MO), Department of Mental Health and Pathological Addictions, AUSL-Modena, Modena, Italy; 5Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; 6Community Mental Health Center, Vignola (MO), Department of Mental Health and Pathological Addictions, AUSL-Modena, Modena, MO, ItalyCorrespondence: Rosaria Di Lorenzo, Department of Mental Health and Pathological Addictions, AUSL-Modena, Service of Psychiatric Diagnosis and Care, via P. Giardini n. 1355, Baggiovara (MO), 41126, Italy, Email r.dilorenzo@ausl.mo.itPurpose: Antipsychotic long-acting injections (AP-LAIs) are indicated for patients affected by schizophrenia especially those with poor treatment adherence.Patients and Methods: To compare paliperidone palmitate 3-monthly (PP3M), paliperidone palmitate one-monthly (PP1M) and haloperidol decanoate (HAL-D) treatment, we enrolled 90 patients with schizophrenia treated in Mental Health Center with one of the three AP-LAIs for at least six months and followed them for another 6 months. At 6 and 12 months of treatment we administered Clinical Global Impression-Severity, Global Assessment of Functioning and World Health Organization Quality of Life-26 items (WHOQOL-BREF). At 1-year treatment, we evaluated relapses (psychiatric hospitalizations and urgent consultations), side effects and drop-outs.Results: We did not highlight any statistically significant difference among the three treatments in relapses and scale scores. Weight increase was significantly higher in PP1M and PP3M groups. Twelve patients (13.3%) discontinued AP-LAI. At 1-year AP-LAI treatment, 69% of patients rated quality of life as “good” or “very good” and 71% declared themselves to be “satisfied” or “very satisfied”.Conclusion: HAL-D, PP1M and PP3M 1-year treatments were similarly effective in preventing relapses and improving quality of life and health satisfaction. All discontinuations in the new 3-monthly antipsychotic treatment were caused by patient refusal to continue it.Keywords: antipsychotic long-acting injections, schizophrenia spectrum disorders, relapses, quality of life, health satisfaction
Published: 2022

5. Precise $^{113}$Cd $\beta$ decay spectral shape measurement and interpretation in terms of possible $g_A$ quenching

Author: Bandac, I., Berge, L., Calvo-Mozota, J. M., Carniti, P., Chapellier, M., Danevich, F. A., Dixon, T., Dumoulin, L., Ferri, F., Giuliani, A., Gotti, C., Gras, Ph., Helis, D. L., Imbert, L., Khalife, H., Kobychev, V. V., Kostensalo, J., Loaiza, P., de Marcillac, P., Marnieros, S., Marrache-Kikuchi, C. A., Martinez, M., Nones, C., Olivieri, E., de Solórzano, A. Ortiz, Pessina, G., Poda, D. V., Scarpaci, J. A., Suhonen, J., Tretyak, V. I., Zarytskyy, M., and Zolotarova, A.
Subjects: Nuclear Experiment
Abstract: Highly forbidden $\beta$ decays provide a sensitive test to nuclear models in a regime in which the decay goes through high spin-multipole states, similar to the neutrinoless double-$\beta$ decay process. There are only 3 nuclei ($^{50}$V, $^{113}$Cd, $^{115}$In) which undergo a $4^{\rm th}$ forbidden non-unique $\beta$ decay. In this work, we compare the experimental $^{113}$Cd spectrum to theoretical spectral shapes in the framework of the spectrum-shape method. We measured with high precision, with the lowest energy threshold and the best energy resolution ever, the $\beta$ spectrum of $^{113}$Cd embedded in a 0.43 kg CdWO$_4$ crystal, operated over 26 days as a bolometer at low temperature in the Canfranc underground laboratory (Spain). We performed a Bayesian fit of the experimental data to three nuclear models (IBFM-2, MQPM and NSM) allowing the reconstruction of the spectral shape as well as the half-life. The fit has two free parameters, one of which is the effective weak axial-vector coupling constant, $g_A^{\text{eff}}$, which resulted in $g_A^{\text{eff}}$ between 1.0 and 1.2, compatible with a possible quenching. Based on the fit, we measured the half-life of the $^{113}$Cd $\beta$ decay including systematic uncertainties as $7.73^{+0.60}_{-0.57} \times 10^{15}$ yr, in agreement with the previous experiments. These results represent a significant step towards a better understanding of low-energy nuclear processes., Comment: Accepted for publication by EPJC
Published: 2024

6. A lightweight Convolutional Neural Network based on U shape structure and Attention Mechanism for Anterior Mediastinum Segmentation

Author: Soleimani-Fard, Sina, Jeong, Won Gi, Ripalda, Francis Ferri, Sasani, Hasti, Choi, Younhee, Deiva, S, Jin, Gong Yong, and Ko, Seok-bum
Subjects: Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract: To automatically detect Anterior Mediastinum Lesions (AMLs) in the Anterior Mediastinum (AM), the primary requirement will be an automatic segmentation model specifically designed for the AM. The prevalence of AML is extremely low, making it challenging to conduct screening research similar to lung cancer screening. Retrospectively reviewing chest CT scans over a specific period to investigate the prevalence of AML requires substantial time. Therefore, developing an Artificial Intelligence (AI) model to find location of AM helps radiologist to enhance their ability to manage workloads and improve diagnostic accuracy for AMLs. In this paper, we introduce a U-shaped structure network to segment AM. Two attention mechanisms were used for maintaining long-range dependencies and localization. In order to have the potential of Multi-Head Self-Attention (MHSA) and a lightweight network, we designed a parallel MHSA named Wide-MHSA (W-MHSA). Maintaining long-range dependencies is crucial for segmentation when we upsample feature maps. Therefore, we designed a Dilated Depth-Wise Parallel Path connection (DDWPP) for this purpose. In order to design a lightweight architecture, we introduced an expanding convolution block and combine it with the proposed W-MHSA for feature extraction in the encoder part of the proposed U-shaped network. The proposed network was trained on 2775 AM cases, which obtained an average Dice Similarity Coefficient (DSC) of 87.83%, mean Intersection over Union (IoU) of 79.16%, and Sensitivity of 89.60%. Our proposed architecture exhibited superior segmentation performance compared to the most advanced segmentation networks, such as Trans Unet, Attention Unet, Res Unet, and Res Unet++.
Published: 2024

7. On dynamical skew braces and skew bracoids

Author: Ferri, Davide
Subjects: Mathematics - Quantum Algebra, Mathematics - Group Theory, 16T25, 81R50
Abstract: Dynamical skew braces are known to produce solutions to the quiver-theoretic Yang--Baxter equation. Under a technical hypothesis, we prove that these solutions are braided groupoids (and hence skew bracoids in the sense of Sheng, Tang and Zhu). Conversely, every connected braided groupoid can be parallelised, making it isomorphic to a dynamical skew brace. We study the combinatorics of these objects, depending on some strings of integer invariants., Comment: 34 pages, 3 figures
Published: 2024

8. Searching for Efficient Linear Layers over a Continuous Space of Structured Matrices

Author: Potapczynski, Andres, Qiu, Shikai, Finzi, Marc, Ferri, Christopher, Chen, Zixi, Goldblum, Micah, Bruss, Bayan, De Sa, Christopher, and Wilson, Andrew Gordon
Subjects: Computer Science - Machine Learning, Statistics - Machine Learning
Abstract: Dense linear layers are the dominant computational bottleneck in large neural networks, presenting a critical need for more efficient alternatives. Previous efforts focused on a small number of hand-crafted structured matrices and neglected to investigate whether these structures can surpass dense layers in terms of compute-optimal scaling laws when both the model size and training examples are optimally allocated. In this work, we present a unifying framework that enables searching among all linear operators expressible via an Einstein summation. This framework encompasses many previously proposed structures, such as low-rank, Kronecker, Tensor-Train, Block Tensor-Train (BTT), and Monarch, along with many novel structures. To analyze the framework, we develop a taxonomy of all such operators based on their computational and algebraic properties and show that differences in the compute-optimal scaling laws are mostly governed by a small number of variables that we introduce. Namely, a small $\omega$ (which measures parameter sharing) and large $\psi$ (which measures the rank) reliably led to better scaling laws. Guided by the insight that full-rank structures that maximize parameters per unit of compute perform the best, we propose BTT-MoE, a novel Mixture-of-Experts (MoE) architecture obtained by sparsifying computation in the BTT structure. In contrast to the standard sparse MoE for each entire feed-forward network, BTT-MoE learns an MoE in every single linear layer of the model, including the projection matrices in the attention blocks. We find BTT-MoE provides a substantial compute-efficiency gain over dense layers and standard MoE., Comment: NeurIPS 2024. Code available at https://github.com/AndPotap/einsum-search
Published: 2024

9. Transmon qubit modeling and characterization for Dark Matter search

Author: Moretti, R., Labranca, D., Campana, P., Carobene, R., Gobbo, M., Castellanos-Beltran, M. A., Olaya, D., Hopkins, P. F., Banchi, L., Borghesi, M., Candido, A., Corti, H. A., D'Elia, A., Faverzani, M., Ferri, E., Nucciotti, A., Origo, L., Pasquale, A., Komnang, A. S. Piedjou, Rettaroli, A., Tocci, S., Carrazza, S., Gatti, C., and Giachero, A.
Subjects: Quantum Physics
Abstract: This study presents the design, simulation, and experimental characterization of a superconducting transmon qubit circuit prototype for potential applications in dark matter detection experiments. We describe a planar circuit design featuring two non-interacting transmon qubits, one with fixed frequency and the other flux tunable. Finite-element simulations were employed to extract key Hamiltonian parameters and optimize component geometries. The qubit was fabricated and then characterized at $20$ mK, allowing for a comparison between simulated and measured qubit parameters. Good agreement was found for transition frequencies and anharmonicities (within 1\% and 10\% respectively) while coupling strengths exhibited larger discrepancies (30\%). We discuss potential causes for measured coherence times falling below expectations ($T_1\sim\,$1-2 \textmu s) and propose strategies for future design improvements. Notably, we demonstrate the application of a hybrid 3D-2D simulation approach for energy participation ratio evaluation, yielding a more accurate estimation of dielectric losses. This work represents an important first step in developing planar Quantum Non-Demolition (QND) single-photon counters for dark matter searches, particularly for axion and dark photon detection schemes.
Published: 2024

10. Psychiatric Emergencies During the Covid-19 Pandemic: A 6-Month Observational Study

Author: Di Lorenzo R, Frattini N, Dragone D, Farina R, Luisi F, Ferrari S, Bandiera G, Rovesti S, and Ferri P
Subjects: psychiatric emergencies, urgent psychiatric consultations, covid-19 pandemic, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract: Rosaria Di Lorenzo,1 Nicoletta Frattini,2 Diego Dragone,3 Riccardo Farina,3 Filippa Luisi,3 Silvia Ferrari,3 Geminiano Bandiera,4 Sergio Rovesti,5 Paola Ferri5 1Psychiatric Intensive Treatment Facility, Mental Health and Drug Abuse Department of AUSL-Modena, Modena, Italy; 2Department of Biomedical, Metabolic and Neural Sciences, School of Nursing, University of Modena and Reggio Emilia, Modena, Italy; 3Department of Biomedical, Metabolic and Neural Sciences, School of Psychiatry, University of Modena and Reggio Emilia, Modena, Italy; 4Emergency Room and Emergency Medicine Unit, General Hospital of Baggiovara, AOU of Modena, Modena, Italy; 5Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, ItalyCorrespondence: Rosaria Di LorenzoPsychiatrist, Psychiatric Intensive Treatment Facility, Mental Health and Drug Abuse Department of AUSL-Modena, Via Paul Harris, 175, Modena, 41122, ItalyEmail r.dilorenzo@ausl.mo.itBackground: The new SARS-CoV-2 has caused an ongoing pandemic. Health prevention measures to contain the outbreak are profoundly affecting the physical and mental health as well as personal freedom of the population.Aim: To evaluate psychiatric emergencies in a 6-month period during the COVID-19 pandemic in 2020 compared to those of the corresponding period of the previous year.Methods: This monocentric observational study preliminarily collected variables of the urgent psychiatric consultations (UPCs) carried out in emergency room (ER) from 1-3-2020 to 31-8-2020 and the socio-demographic and clinical characteristics of patients who required UPCs in the 6-month period, comparing these data with those collected from 1-3-2019 to 31-8-2019. The data, collected in alpha-numeric code, were statistically analyzed through STATA 12-2011.Results: This research reported a reduction of both UPCs and hospital psychiatric admissions. Concomitantly, we observed an increase of UPCs required by people already being treated by psychiatric and other health services, residents in psychiatric facilities and non-Italians. In 2020, differently from 2019, the most frequent reasons for urgent psychiatric consultations were aggressive behavior and adjustment disorders with anxiety and depressive mood.Conclusion: This preliminary study suggests that, during the COVID-19 epidemic, urgent psychiatric consultations in ER were reduced, except for the most vulnerable people due to their clinical and/or social conditions.Keywords: psychiatric emergencies, urgent psychiatric consultations, COVID-19 pandemic
Published: 2021

11. Effectiveness of a Web-Based Course on Vaccination Competence in Higher Education: The Eduvac Erasmus+ Project

Author: Dimitra Perifanou, Eleni Konstantinou, Anne Nikula, Kristina Grendova, Aija Ahokas, Joan-Carles Casas-Baroy, Daniela Cavani, Paola Ferri, Paola Galbany-Estragués, Cinzia Gradellini, Michaela Machajova, Daniela Mecugni, Sari Nyman, Xavier Palomar-Aumatell, Janka Prnova, Montse Romero Mas, Carme Roure Pujol, Heli Thomander, and Evanthia Sakellari
Abstract: Immunization is a highly cost-effective investment in health, proven to be an effective tool in controlling and eliminating dangerous infectious diseases. Health science students require evidence-based knowledge to tackle challenges in healthcare, particularly in the field of vaccination. The aim of the current study is to asses students' knowledge on vaccinations and further explore their feedback after attending Educating Vaccination Competence web-based course (EDUVAC web-based course). Students from five Higher Educational Institutes voluntarily participated in the EDUVAC web-based course. The course provided various study materials, including PowerPoint presentations, videos, quizzes, texts, and references to reputable websites. It also offered small assignments and self-tests for self-evaluation. An online questionnaire was available to students before and after they completed the EDUVAC web-based course. The mean knowledge score on vaccines increased significantly after the EDUVAC web-based course (p<0.001). The majority of the students (95%) felt that the web-based course has benefitted them for their future career and 96.4% would encourage other students to attend the EDUVAC web-based course. Overall, our findings suggest that EDUVAC is a valuable resource for those seeking to enhance their understanding of vaccination.
Published: 2024

12. Perceptions of Caring Behavior Among Undergraduate Nursing Students: A Three-Cohort Observational Study

Author: Ferri P, Stifani S, Morotti E, Nuvoletta M, Bonetti L, Rovesti S, Cutino A, and Di Lorenzo R
Subjects: caring behaviors inventory, caring, expressive caring, instrumental caring, nursing education, nursing students, Psychology, BF1-990, Industrial psychology, HF5548.7-5548.85
Abstract: Paola Ferri,1 Serena Stifani,2 Elena Morotti,2 Maria Nuvoletta,3 Loris Bonetti,4 Sergio Rovesti,1 Anna Cutino,5 Rosaria Di Lorenzo6 1Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41125, Italy; 2School of Nursing, University of Modena and Reggio Emilia, Modena 41124, Italy; 3Occupational Medicine, Maserati SPA, Modena 41121, Italy; 4Nursing Research and Development Unit, Oncology Institute of Southern Switzerland, Bellinzona 6500, Switzerland; 5Psychiatry, University of Modena and Reggio Emilia, Modena 41124, Italy; 6Psychiatric Intensive Treatment Facility, Mental Health and Drug Abuse Department of AUSL-Modena, Modena 41122, ItalyCorrespondence: Paola FerriDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, via Campi, 287, Modena 41125, ItalyEmail paola.ferri@unimore.itIntroduction: Increase in the knowledge of “caring science” among nurses plays a key role in ensuring a correct caring behavior towards patients. Caring training for students is a priority in nursing education, but unfortunately there are limited and conflicting studies which explore this outcome. The purpose of this observational study was to explore the perceptions of caring behaviors by nursing students during their clinical practice training in order to highlight if the level of caring behaviors changes as the nursing course progresses.Materials and Methods: The Caring Behaviors Inventory-24 (CBI-24) was administered to 331 students, enrolled in the three years of an Italian Nursing Course, who accepted to participate in the study (89.2% response rate). The data were analyzed using SPSS software version 26.0 (SPSS Inc., Chicago, IL).Results: The total mean score of CBI-24 was 4.82 in the first, 5.12 in the second and 5.26 in the third-year students. The CBI-24 dimensions “Responding to individual needs” and “Being with” obtained the highest scores among the students of the first year. At the end of the first year, our students were already able to perform expressive caring, whereas instrumental caring developed at a high level in the second and third years. We did not highlight any statistically significant difference between the two gender CBI-24 item scores.Conclusion: In light of our results, we put in evidence that Nursing Degree Programme favours the development in students of both relational and technical components of caring behaviors. We hope that in future students’ self-assessment of caring behaviors could be considered an educational outcome for Nursing Programme.Keywords: Caring Behaviors Inventory, caring, expressive caring, instrumental caring, nursing education, nursing students
Published: 2020

13. Data-driven background model for the CUORE experiment

Author: Adams, DQ, Alduino, C, Alfonso, K, Avignone, FT, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Cao, J, Capelli, S, Capelli, C, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Cremonesi, O, Creswick, RJ, D’Addabbo, A, Dafinei, I, Del Corso, F, Dell’Oro, S, Di Domizio, S, Di Lorenzo, S, Dixon, T, Dompè, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Ghislandi, S, Giachero, A, Girola, M, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Guillaumon, PV, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Helis, DL, Huang, HZ, Keppel, G, Kolomensky, Yu G, Kowalski, R, Liu, R, Ma, L, G., Y, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Moore, MN, Napolitano, T, Nastasi, M, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O’Donnell, T, Olmi, M, Oregui, BT, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Ponce, I, Pottebaum, EG, Pozzi, S, Previtali, E, Puiu, A, Quitadamo, S, Ressa, A, Rosenfeld, C, and Schmidt, B
Subjects: Nuclear and Plasma Physics, Physical Sciences, Cancer
Abstract: We present the model we developed to reconstruct the CUORE radioactive background based on the analysis of an experimental exposure of 1038.4 kg yr. The data reconstruction relies on a simultaneous Bayesian fit applied to energy spectra over a broad energy range. The high granularity of the CUORE detector, together with the large exposure and extended stable operations, allow for an in-depth exploration of both spatial and time dependence of backgrounds. We achieve high sensitivity to both bulk and surface activities of the materials of the setup, detecting levels as low as 10 nBq kg-1 and 0.1 nBq cm-2, respectively. We compare the contamination levels we extract from the background model with prior radio-assay data, which informs future background risk mitigation strategies. The results of this background model play a crucial role in constructing the background budget for the CUPID experiment as it will exploit the same CUORE infrastructure.
Published: 2024

14. Desynchronization Index: a New Approach for Exploring Complex Epileptogenic Networks in Stereoelectroencephalography

Author: Mason, Federico, Ferri, Lorenzo, Di Vito, Lidia, Alvisi, Lara, Zanuttini, Luca, Martinoni, Matteo, Mai, Roberto, Cardinale, Francesco, Tinuper, Paolo, Michelucci, Roberto, Pasini, Elena, and Bisulli, Francesca
Subjects: Electrical Engineering and Systems Science - Signal Processing, Quantitative Biology - Neurons and Cognition
Abstract: Stereoelectroencephalography (SEEG) is an invasive surgical procedure to record the electrical activities in cortical brain regions, aiming at identifying the Epileptogenic Zone (EZ) in patients with drug-resistant epilepsy. To improve the accuracy of the EZ definition, SEEG analysis can be supported by computational tools, among which the Epileptogenic Index (EI) represents the most common solution. However, the scientific community has still not found an agreement on which quantitative biomarkers can characterize the cortical sites within the EZ. In this work, we design a new algorithm, named Desynchronization Index (DI), to assist neurophysiologists in SEEG interpretation. Our algorithm estimates the effective connectivity between cortical sites and hypothesizes that the EZ is identified by those sites getting abnormally desynchronized from the network during the seizure generation. We test the proposed method over a SEEG dataset of 10 seizures, comparing its accuracy in terms of EZ definition against the EI algorithm and clinical ground truth. Our results indicate that the DI algorithm underscores specific connectivity dynamics that can hardly be identified with a pure visual analysis, increasing sensitivity in detecting epileptogenic cortical sites.
Published: 2024

15. Gapless spin excitations in nanographene-based antiferromagnetic spin-1/2 Heisenberg chains

Author: Zhao, Chenxiao, Yang, Lin, Henriques, João C. G., Ferri-Cortés, Mar, Catarina, Gonçalo, Pignedoli, Carlo A., Ma, Ji, Feng, Xinliang, Ruffieux, Pascal, Fernández-Rossier, Joaquín, and Fasel, Roman
Subjects: Condensed Matter - Materials Science, Condensed Matter - Mesoscale and Nanoscale Physics, Quantum Physics
Abstract: Haldane's seminal work established two fundamentally different types of excitation spectra for antiferromagnetic Heisenberg quantum spin chains: gapped excitations in integer-spin chains and gapless excitations in half-integer-spin chains. In finite-length half-integer spin chains, quantization, however, induces a gap in the excitation spectrum, with the upper bound given by the Lieb-Schulz-Mattis (LSM) theorem. Here, we investigate the length-dependent excitations in spin-1/2 Heisenberg chains obtained by covalently linking olympicenes--Olympic rings shaped nanographenes carrying spin-1/2--into one-dimensional chains. The large exchange interaction (J~38 mV) between olympicenes and the negligible magnetic anisotropy in these nanographenes make them an ideal platform for studying quantum spin excitations, which we directly measure using inelastic electron tunneling spectroscopy. We observe a power-law decay of the lowest excitation energy with increasing chain length L, remaining below the LSM boundary. In a long chain with L = 50, a nearly V-shaped excitation continuum is observed, reinforcing the system's gapless nature in the thermodynamic limit. Finally, we visualize the standing wave of a single spinon confined in odd-numbered chains using low-bias current maps. Our results provide compelling evidence for the realization of a one-dimensional analog of a gapless spin liquid., Comment: 5 figures. arXiv admin note: text overlap with arXiv:2402.13590
Published: 2024

16. A fully explicit isogeometric collocation formulation for the dynamics of geometrically exact beams

Author: Ferri, Giulio, Kiendl, Josef, Reali, Alessandro, and Marino, Enzo
Subjects: Computer Science - Computational Engineering, Finance, and Science, Mathematics - Numerical Analysis
Abstract: We present a fully explicit dynamic formulation for geometrically exact shear-deformable beams. The starting point of this work is an existing isogeometric collocation (IGA-C) formulation which is explicit in the strict sense of the time integration algorithm, but still requires a system matrix inversion due to the use of a consistent mass matrix. Moreover, in that work, the efficiency was also limited by an iterative solution scheme needed due to the presence of a nonlinear term in the time-discretized rotational balance equation. In the present paper, we address these limitations and propose a novel fully explicit formulation able to preserve high-order accuracy in space. This is done by extending a predictor--multicorrector approach, originally proposed for standard elastodynamics, to the case of the rotational dynamics of geometrically exact beams. The procedure relies on decoupling the Neumann boundary conditions and on a rearrangement and rescaling of the mass matrix. We demonstrate that an additional gain in terms of computational cost is obtained by properly removing the angular velocity-dependent nonlinear term in the rotational balance equation without any significant loss in terms of accuracy. The high-order spatial accuracy and the improved efficiency of the proposed formulation compared to the existing one are demonstrated through some numerical experiments covering different combinations of boundary conditions.
Published: 2024

17. Explainable Machine Learning and Deep Learning Models for Predicting TAS2R-Bitter Molecule Interactions

Author: Ferri, Francesco, Cannariato, Marco, Pallante, Lorenzo, Zizzi, Eric A., and Deriu, Marco A.
Subjects: Quantitative Biology - Biomolecules, Quantitative Biology - Quantitative Methods
Abstract: This work aims to develop explainable models to predict the interactions between bitter molecules and TAS2Rs via traditional machine-learning and deep-learning methods starting from experimentally validated data. Bitterness is one of the five basic taste modalities that can be perceived by humans and other mammals. It is mediated by a family of G protein-coupled receptors (GPCRs), namely taste receptor type 2 (TAS2R) or bitter taste receptors. Furthermore, TAS2Rs participate in numerous functions beyond the gustatory system and have implications for various diseases due to their expression in various extra-oral tissues. For this reason, predicting the specific ligand-TAS2Rs interactions can be useful not only in the field of taste perception but also in the broader context of drug design. Considering that in-vitro screening of potential TAS2R ligands is expensive and time-consuming, machine learning (ML) and deep learning (DL) emerged as powerful tools to assist in the selection of ligands and targets for experimental studies and enhance our understanding of bitter receptor roles. In this context, ML and DL models developed in this work are both characterized by high performance and easy applicability. Furthermore, they can be synergistically integrated to enhance model explainability and facilitate the interpretation of results. Hence, the presented models promote a comprehensive understanding of the molecular characteristics of bitter compounds and the design of novel bitterants tailored to target specific TAS2Rs of interest.
Published: 2024

18. Search for fractionally charged particles with CUORE

Author: CUORE Collaboration, Adams, D. Q., Alduino, C., Alfonso, K., Avignone III, F. T., Azzolini, O., Bari, G., Bellini, F., Benato, G., Beretta, M., Biassoni, M., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Caminata, A., Campani, A., Cao, J., Capelli, S., Capelli, C., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chiesa, D., Clemenza, M., Copello, S., Cremonesi, O., Creswick, R. J., D'Addabbo, A., Dafinei, I., Del Corso, F., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompè, V., Fang, D. Q., Fantini, G., Faverzani, M., Ferri, E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Ghislandi, S., Giachero, A., Girola, M., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Keppel, G., Kolomensky, Yu. G., Kowalski, R., Liu, R., Ma, L., Ma, Y. G., Marini, L., Maruyama, R. H., Mayer, D., Mei, Y., Moore, M. N., Napolitano, T., Nastasi, M., Nones, C., Norman, E. B., Nucciotti, A., Nutini, I., O'Donnell, T., Olmi, M., Oregui, B. T., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Pottebaum, E. G., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rosenfeld, C., Schmidt, B., Sharma, V., Singh, V., Sisti, M., Speller, D., Stark, P., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, A., Torres, J. A., Vetter, K. J., Vignati, M., Wagaarachchi, S. L., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Zimmermann, S., and Zucchelli, S.
Subjects: High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract: The Cryogenic Underground Observatory for Rare Events (CUORE) is a detector array comprised by 988 5$\;$cm$\times$5$\;$cm$\times$5$\;$cm TeO$_2$ crystals held below 20 mK, primarily searching for neutrinoless double-beta decay in $^{130}$Te. Unprecedented in size amongst cryogenic calorimetric experiments, CUORE provides a promising setting for the study of exotic through-going particles. Using the first tonne-year of CUORE's exposure, we perform a search for hypothesized fractionally charged particles (FCPs), which are well-motivated by various Standard Model extensions and would have suppressed interactions with matter. No excess of FCP candidate tracks is observed over background, setting leading limits on the underground FCP flux with charges between $e/24-e/5$ at 90\% confidence level. Using the low background environment and segmented geometry of CUORE, we establish the sensitivity of tonne-scale sub-Kelvin detectors to diverse signatures of new physics., Comment: 7 pages, 5 figures
Published: 2024

19. Matched pairs and Yetter-Drinfeld braces

Author: Ferri, Davide and Sciandra, Andrea
Subjects: Mathematics - Quantum Algebra, Mathematics - Category Theory, Mathematics - Rings and Algebras, Mathematics - Representation Theory, Primary 16T05, Secondary 16T25, 18M15
Abstract: It is proven that a matched pair of actions on a Hopf algebra $H$ is equivalent to the datum of a Yetter-Drinfeld brace, which is a novel structure generalising Hopf braces. This improves a theorem by Angiono, Galindo and Vendramin, originally stated for cocommutative Hopf braces. These Yetter-Drinfeld braces produce Hopf algebras in the category of Yetter-Drinfeld modules over $H$, through an operation that generalises Majid's transmutation. A characterisation of Yetter-Drinfeld braces via 1-cocycles, in analogy to the one for Hopf braces, is given. Every coquasitriangular Hopf algebra $H$ will be seen to yield a Yetter-Drinfeld brace, where the additional structure on $H$ is given by the transmutation. We compute explicit examples of Yetter-Drinfeld braces on the Sweedler's Hopf algebra, on the algebras $E(n)$, on $\mathrm{SL}_{q}(2)$, and an example in the class of Suzuki algebras., Comment: 29 pages
Published: 2024

20. A novel approach to graph distinction through GENEOs and permutants

Author: Bocchi, Giovanni, Ferri, Massimo, and Frosini, Patrizio
Subjects: Computer Science - Machine Learning, Mathematics - Group Theory
Abstract: The theory of Group Equivariant Non-Expansive Operators (GENEOs) was initially developed in Topological Data Analysis for the geometric approximation of data observers, including their invariances and symmetries. This paper departs from that line of research and explores the use of GENEOs for distinguishing $r$-regular graphs up to isomorphisms. In doing so, we aim to test the capabilities and flexibility of these operators. Our experiments show that GENEOs offer a good compromise between efficiency and computational cost in comparing $r$-regular graphs, while their actions on data are easily interpretable. This supports the idea that GENEOs could be a general-purpose approach to discriminative problems in Machine Learning when some structural information about data and observers is explicitly given.
Published: 2024

21. Development of large-volume $^{130}$TeO$_2$ bolometers for the CROSS $2\beta$ decay search experiment

Author: Avignone III, F. T., Barabash, A. S., Berest, V., Bergé, L., Calvo-Mozota, J. M., Carniti, P., Chapellier, M., Dafinei, I., Danevich, F. A., Dumoulin, L., Ferella, F., Ferri, F., Gallas, A., Giuliani, A., Gotti, C., Gras, P., Ianni, A., Imbert, L., Khalife, H., Kobychev, V. V., Konovalov, S. I., Loaiza, P., de Marcillac, P., Marnieros, S., Marrache-Kikuchi, C. A., Martinez, M., Nisi, S., Nones, C., Olivieri, E., de Solórzano, A. Ortiz, Peinaud, Y., Pessina, G., Poda, D. V., Rosier, Ph., Scarpaci, J. A., Tretyak, V. I., Umatov, V. I., Zarytskyy, M. M., and Zolotarova, A.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: We report on the development of thermal detectors based on large-size tellurium dioxide crystals (45x45x45 mm), containing tellurium enriched in $^{130}$Te to about 91%, for the CROSS double-beta decay experiment. A powder used for the crystals growth was additionally purified by the directional solidification method, resulting in the reduction of the concentration of impurities by a factor 10, to a few ppm of the total concentration of residual elements (the main impurity is Fe). The purest part of the ingot (the first ~200 mm, about 80% of the total length of the cylindrical part of the ingot) was determined by scanning segregation profiles of impurities and used for the $^{130}$TeO$_2$ powder production with no evidence of re-contamination. The crystal growth was verified with precursors produced from powder with natural Te isotopic composition, and two small-size (20x20x10 mm) samples were tested at a sea-level laboratory showing high bolometric and spectrometric performance together with acceptable $^{210}$Po content (below 10 mBq/kg). This growth method was then applied for the production of six large cubic $^{130}$TeO$_2$ crystals and 4 of them were taken randomly to be characterized at the Canfranc underground laboratory, in the CROSS-dedicated low-background cryogenic facility. Two $^{130}$TeO$_2$ samples were coated with a thin, $O$(100 nm), metal film in form of Al layer (on 4 sides) or AlPd grid (on a single side) to investigate the possibility to tag surface events by pulse-shape discrimination. Similarly to the small natural precursors, large-volume $^{130}$TeO$_2$ bolometers show high performance and even better internal purity ($^{210}$Po activity $\sim$ 1 mBq/kg, while activities of $^{228}$Th and $^{226}$Ra are below 0.01 mBq/kg), satisfying requirements for the CROSS and, potentially, next-generation experiments., Comment: Submitted to JINST; 22 pages, 11 figures, 4 tables
Published: 2024

22. Friction factor correlation for airflow through broken rocks and its applications in mine ventilation

Author: Leyla Amiri, Seyed Ali Ghoreishi-Madiseh, Ferri P. Hassani, and Agus P. Sasmito
Subjects: Broken rock, Fractured rock, Packed rock bed, Large particle, Pressure drop, Friction factor, Mining engineering. Metallurgy, TN1-997
Abstract: The Atkinson equation along with its friction factor is commonly used to estimate pressure requirement in mine ventilation. However, friction factor correlation of flow through broken rock, typically found in blasted stope, gob, rock pit or block caving rock deposits, etc., is currently unavailable. Also, it is impractical to conduct direct measurements of flow resistance in an inaccessible broken rock zone. This paper aims to develop a new friction factor correlation of flow through broken rock that can be used directly in Atkinson equation. The proposed correlation is valid for broken rocks with diameter between 0.04 and 1.2 m and porosity ranging from 0.23 to 0.7.
Published: 2020
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23. Attitude Towards Drug Therapy in a Community Mental Health Center Evaluated by the Drug Attitude Inventory

Author: Di Lorenzo R, Perrone D, Montorsi A, Balducci J, Rovesti S, and Ferri P
Subjects: attitude towards drugs, psychiatric disorders, community mental health center, therapy adherence, Medicine (General), R5-920
Abstract: Rosaria Di Lorenzo,1 Daniela Perrone,2 Anushree Montorsi,3 Jessica Balducci,4 Sergio Rovesti,5 Paola Ferri6 1Mental Health and Drug Abuse Department of AUSL-Modena, Psychiatric Intensive Treatment Facility, Modena 41122, Italy; 2Mental Health Department, UOC Psychiatry, Fermo 63900, Italy; 3School of Nursing, University of Modena and Reggio Emilia, Modena 41124, Italy; 4School of Specialization in Psychiatry, University of Modena and Reggio Emilia, Modena 41124, Italy; 5General and Applied Hygiene, Department of Biomedical, Metabolic and Neural Sciences, Public Health Section, Modena, 41125, Italy; 6Nursing, Department of Biomedical, Metabolic and Neural Sciences, Public Health Section, Modena, 41125, ItalyCorrespondence: Rosaria Di Lorenzo Email saradilorenzo1@alice.itIntroduction: Negative attitude towards drug therapy can foster limited adherence to treatment, which remains one of the biggest obstacles for implementing effective treatments, especially long term.Purposes: The purposes of the study were 1) to evaluate the attitude towards drug therapy among a representative sample of patients treated in a community psychiatric service using 30-item Drug Attitude Inventory (DAI-30); 2) to evaluate the DAI-30 dimensions, applying factorial analysis; and 3) to highlight the socio-demographic and clinical variables correlated to DAI-30 score and factors.Methods: The DAI was administered, over a 7-month period, to all patients treated in our psychiatric outpatient services who agreed to participate in this study and provided their informed consent. Data were statistically analyzed.Results: With a response rate of 63.3%, 164 females and 136 males completed the DAI-30 with an average score of 14.24 (± 10.46 SD), indicating moderately positive attitude towards drug therapy. The analysis of DAI-30 internal consistency confirmed its reliability (Cronbach’s alpha=0.84). Our factorial analysis highlighted three factors: Factor 1 (Cronbach’s alpha=0.81), composed of 7 items which indicate positive, trustful attitude; Factor 2 (Cronbach’s alpha=0.78), composed of 5 items indicating negative attitude of suspiciousness; and Factor 3 (Cronbach’s alpha=0.66), composed of 4 items suggesting defensive and control attitude towards drug therapy.Discussion: Among the selected variables, “monotherapy” and “total number of hospitalizations” were negatively correlated to the final score of DAI-30, whereas being “married” was positively correlated to it, in a statistically significant way, using the multiple linear regression model. These correlations suggest that positive attitude towards drug therapy could be reinforced by the condition of being married and reduced by relapses with hospitalization, as literature highlighted, and, paradoxically, by a monotherapy, which could suggest a sort of psychological dependence on therapy and, indirectly, on psychiatric service, potentially correlated to the long-term treatments of our patients.Keywords: attitude towards drugs, psychiatric disorders, community mental health center, therapy adherence
Published: 2020

24. Retrospective Analysis of Factors Associated with Long-Stay Hospitalizations in an Acute Psychiatric Ward

Author: Di Lorenzo R, Montardi G, Panza L, Del Giovane C, Saraceni S, Rovesti S, and Ferri P
Subjects: psychiatric long-stay, acute psychiatric ward, predictors of long-stay, illness severity, Public aspects of medicine, RA1-1270
Abstract: Rosaria Di Lorenzo,1 Giulia Montardi,2 Leda Panza,3 Cinzia Del Giovane,4 Serena Saraceni,2 Sergio Rovesti,5 Paola Ferri6 1Psychiatric Intensive Treatment Facility, Department of Mental Health and Drug Abuse, Az-USL Modena, Modena 41122, Italy; 2School of Specialization in Psychiatry, University of Modena and Reggio Emilia, Modena 41124, Italy; 3School of Nursing, University of Modena and Reggio Emilia, Modena 41124, Italy; 4Head of Statistics and Methodology, Institute of Primary Health Care (BIHAM), Bern, Switzerland; 5General and Applied Hygiene, Department of Biomedical, Metabolic and Neural Sciences, Modena 41125, Italy; 6Nursing, Department of Biomedical, Metabolic and Neural Sciences, Modena 41125, ItalyCorrespondence: Rosaria Di LorenzoPsychiatrist, Psychiatric Intensive Treatment Facility, Az-USL Modena, Modena 41122, ItalyEmail r.dilorenzo@ausl.mo.itPurpose: To evaluate the longest hospitalizations in an acute psychiatric ward [Service of Psychiatric Diagnosis and Treatment (SPDT)] and the related demographic, clinical and organizational variables to understand the factors that contribute to long-stay (LOS) phenomenon. The term “long stay” indicates clinical, social and organizational problems responsible for delayed discharges. In psychiatry, clinical severity, social dysfunction and/or health-care system organization appear relevant factors in prolonging stays.Patients and Methods: We divided all the SPDT hospitalizations from 1 January 2010 to 31 December 2015 into two groups based on the 97.5th percentile of duration: ≤ 36 day (n=3254) and > 36 day (n=81) stays, in order to compare the two groups for the selected variables. Comparisons were made using Pearson’s chi-square for categorical data and t-test for continuous variables, the correlation between the LOS, as a dependent variable, and the selected variables was analyzed in stepwise multiple linear regression and in multiple logistic regression models.Results: The longest hospitalizations were significantly related to the diagnosis of “schizophrenia and other psychosis” (Pearson Chi2=17.24; p=0.045), the presence of moderate and severe aggressiveness (Pearson chi2=29; p=0.000), compulsory treatment (Pearson Chi2=8.05; p=0.005), parenteral or other route administration of psycho-pharmacotherapy (Pearson Chi2=12.91; p=0.007), poli-therapy (Pearson Chi2=6.40; p=0.041), complex psychiatric activities (Pearson Chi2=12.26; p=0.002) and rehabilitative programs (Pearson Chi2=37.05; p=0.000) during the hospitalization and at discharge (Pearson Chi2=29.89; p=0.000). Many demographic and clinical variables were statistically significantly correlated to the LOS at our multiple linear and logistic regression model.Conclusion: In our sample, clinical illness severity and need for complex therapeutic and rehabilitative treatments were associated with prolonged psychiatric hospitalizations. Understanding this phenomenon can have not only economic but also clinical, ethical and social relevance.Keywords: psychiatric long-stay, acute psychiatric ward, predictors of long-stay, illness severity
Published: 2020

25. Effect of expert-patient teaching on empathy in nursing students: a randomized controlled trial

Author: Ferri P, Rovesti S, Padula MS, D’Amico R, and Di Lorenzo R
Subjects: Empathy, Nursing education, Students, Expert patient, Psychology, BF1-990, Industrial psychology, HF5548.7-5548.85
Abstract: Paola Ferri,1 Sergio Rovesti,1 Maria Stella Padula,1 Roberto D’Amico,2 Rosaria Di Lorenzo31Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena 41125, Italy; 2Research and Innovation Area, Department of Maternal-Infant and Adult Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena 41124, Italy; 3Psychiatric Intensive Treatment Facility, Department of Mental Health and Drug Abuse, AUSL Modena, Modena 41122, ItalyBackground: Empathy is a relevant clinical competence for nursing students. Involvement of expert patients in nursing education could help students develop their innate capacity to empathize.Objective: To evaluate the effect of expert-patient teaching on empathy development in nursing students.Methods: This randomized controlled trial was conducted among 144 first-year undergraduate nursing students divided into two equal groups. In the experimental group, the educational intervention consisted of a seminar focused on empathy, followed by a presentation on expert-patient function. Subsequently, each student participated in two interactive meetings with nursing teacher and expert patient. At the end, the nursing teacher encouraged students to reflect on this experience. In the control group, students only attended a similar seminar focused on empathy and afterward participated in two interactive meetings with a nursing teacher to reflect on this topic without expert-patient involvement. Before (T0) and after (T1) the training intervention, the Balanced Emotional Empathy Scale, Jefferson Scale of Empathy — Health Professions Student (JSE-HPS), and a short demographic questionnaire were administered to the two student groups to measure their empathy levels. The study was approved by the Local Ethics Committee of Area Vasta Emilia Nord (protocol 1763, May 11, 2017). Data were statistically analyzed.Results: We found a statistically significant difference between mean scores at T0 and T1 in both scales in the experimental group. Male students, who presented significantly lower levels of empathy at baseline in comparison with females, showed increased in empathy after training on the the Balanced Emotional Empathy Scale in both the experimental and control groups.Conclusion: The present study highlights that involvement of expert patients in teaching is effective in improving empathy levels in both male and female nursing students. Expert-patient teaching can be a promising nursing-education modality for developing empathy.Keywords: empathy, nursing education, students, expert patient
Published: 2019

26. Effectiveness of 1-year treatment with long-acting formulation of aripiprazole, haloperidol, or paliperidone in patients with schizophrenia: retrospective study in a real-world clinical setting

Author: Di Lorenzo R, Ferri P, Cameli M, Rovesti S, and Piemonte C
Subjects: Paliperidone Palmitate once-monthly Haloperidol decanoate Aripiprazole prolonged release once-monthly Schizophrenia relapses and clinical course Long-acting treatment effectiveness. First generation antipsychotics Second generation antipsychotics, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract: Rosaria Di Lorenzo,1 Paola Ferri,2 Michela Cameli,3 Sergio Rovesti,4 Chiara Piemonte5 1Psychiatric Intensive Treatment Facility, Department of Mental Health and Drug Abuse, AUSL Modena, Modena, Italy; 2Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; 3Private Accredited Psychiatric Hospital, Villa degli Ulivi, Caserta, Italy; 4Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; 5Private Accredited Psychiatric Hospital, Villa Igea, Modena, Italy Background: Schizophrenia is a chronic mental illness that requires lifelong antipsychotic treatment. Therapy discontinuation, often due to poor adherence, increases the risk of relapses after both first and subsequent psychotic episodes. Long-acting injectable (LAI) antipsychotic drugs (APDs) have been introduced to increase therapeutic adherence, reducing blood-level variability compared to corresponding oral preparations. Purpose: To compare the effectiveness of three LAI-APDs: aripiprazole (Apr) prolonged release once monthly (OM) haloperidol decanoate (Hal-D) and paliperidone palmitate (PP-OM). Methods: We retrospectively collected data for all patients with schizophrenia or other psychoses (n=217) treated with the three LAI-APDs for the first time from January 1, 2012 to October 31, 2016: n=48 with Apr-OM, n=55 with Hal-D, and n=114 with PP-OM. After 6 and 12 months of LAI treatments, we assessed clinical and functioning improvement, urgent consultations, psychiatric hospitalizations, adverse effects, and dropout. We compared urgent consultations and psychiatric hospitalizations required by the same patient 6 and 12 months before and after LAI implementation. Data were statistically analyzed. Results: The three LAI groups differed significantly only for “need for economic support from social service” (more frequent in the Hal-D group) and “schizoaffective disorder” (prevalent in the Apr-OM group). Apr-OM was prescribed at the maximum dose required by the official guidelines, whereas the other two LAIs were prescribed at lower doses. After 6 and 12 months’ treatment with the three LAI-APDs, we registered similar and significant reductions in both urgent consultations and psychiatric hospitalizations (P
Published: 2019

27. Large muscle group movements during sleep in restless leg syndrome: neurophysiological and clinical implications.

Author: Mogavero, Maria, Congiu, Patrizia, Lanza, Giuseppe, Marelli, Sara, Castelnuovo, Alessandra, Puligheddu, Monica, DelRosso, Lourdes, Ferini Strambi, Luigi, and Ferri, Raffaele
Subjects: arousals, isolated leg movements during sleep, large muscle group movements during sleep, periodic leg movements during sleep, restless legs syndrome, sleep-related movements, Humans, Restless Legs Syndrome, Male, Female, Middle Aged, Polysomnography, Retrospective Studies, Adult, Sleep Stages, Movement, Sleep, Electromyography, Aged
Abstract: STUDY OBJECTIVES: Recently, criteria have been drawn up for large muscle group movements during sleep (LMM), defined as movements lasting for 3-45 seconds in adults, which are often accompanied by changes in sleep stage, arousals, and increases in heart rate. The aim of this study was to characterize LMM in restless legs syndrome (RLS) in order to better evaluate their impact on the neurophysiology of the disorder and, therefore, the possible clinical implications. METHODS: Consecutive, drug-free patients diagnosed with RLS and controls, aged 18 years or more, were retrospectively enrolled. Leg movement activity-short-interval (SILMS), periodic (PLMS), and isolated (ISOLMS) leg movements during sleep-and LMM were detected and scored. RESULTS: In total, 100 patients and 67 controls were recruited. All movement measures were significantly higher in RLS. A significant positive correlation was found between LMM and ISOLMS index but not PLMS index in both groups. LMM index showed a significant negative correlation with total sleep time, sleep efficiency, and percentage of sleep stages N3 and R, as well as a significant positive correlation with the number of awakenings, and percentage of sleep stages N1 and N2 only in patients with RLS. No significant correlation was found between either LMM or PLMS index and RLS severity. CONCLUSIONS: Different types of movements, including SILMS, ISOLMS, and LMM, play somewhat distinct roles in sleep neurophysiology in RLS. Notably, LMM, a newly recognized category of movements, demonstrates associations with sleep architecture instability and fragmentation, arousals, and awakenings, suggesting potential clinical implications.
Published: 2024

28. A novel mechanical design of a bolometric array for the CROSS double-beta decay experiment

Author: Auguste, D., Barabash, A. S., Berest, V., Bergé, L., Calvo-Mozota, J. M., Carniti, P., Chapellier, M., Dafinei, I., Danevich, F. A., Dixon, T., Dumoulin, L., Ferri, F., Gallas, A., Giuliani, A., Gotti, C., Gras, P., Ianni, A., Imbert, L., Khalife, H., Kobychev, V. V., Konovalov, S. I., Loaiza, P., de Marcillac, P., Marnieros, S., Marrache-Kikuchi, C. A., Martinez, M., Nones, C., Olivieri, E., de Solórzano, A. Ortiz, Peinaud, Y., Pessina, G., Poda, D. V., Rosier, Ph., Scarpaci, J. A., Tretyak, V. I., Umatov, V. I., Zarytskyy, M. M., and Zolotarova, A.
Subjects: Physics - Instrumentation and Detectors
Abstract: The CROSS experiment will search for neutrinoless double-beta decay using a specific mechanical structure to hold thermal detectors. The design of the structure was tuned to minimize the background contribution, keeping an optimal detector performance. A single module of the structure holds two scintillating bolometers (with a crystal size of 45x45x45 mm and a Ge slab facing the crystal's upper side) in the Cu frame, allowing for a modular construction of a large-scale array. Two designs are released: the initial $Thick$ version contains around 15% of Cu over the crystal mass (lithium molybdate, LMO), while this ratio is reduced to ~6% in a finer ($Slim$) design. Both designs were tested extensively at aboveground (IJCLab, France) and underground (LSC, Spain) laboratories. In particular, at LSC we used a pulse-tube-based CROSS facility to operate a 6-crystal array of LMOs enriched/depleted in $^{100}$Mo. The tested LMOs show high spectrometric performance in both designs; notably, the measured energy resolution is 5--7 keV FWHM at 2615 keV $\gamma$s, nearby the Q-value of $^{100}$Mo (3034 keV). Due to the absence of a reflective cavity around LMOs, a low scintillation signal is detected by Ge bolometers: ~0.3 keV (150 photons) for 1-MeV $\gamma$($\beta$) LMO-event. Despite that, an acceptable separation between $\alpha$ and $\gamma$($\beta$) events is achieved with most devices. The highest efficiency is reached with light detectors in the $Thick$ design thanks to a lower baseline noise width (0.05--0.09 keV RMS) when compared to that obtained in the $Slim$ version (0.10--0.35 keV RMS). Given the pivotal role of bolometric photodetectors for particle identification and random coincidences rejection, we will use the structure here described with upgraded light detectors, featuring thermal signal amplification via the Neganov-Trofimov-Luke effect, as also demonstrated in the present work., Comment: Submitted to JINST; 31 pages, 16 figures, 5 tables
Published: 2024

29. New Approaches to Old Problems? Thinking About a New Design of the AML/CFT Strategy

Author: Ferri, Chiara
Subjects: Economics - Theoretical Economics, Computer Science - Emerging Technologies
Abstract: The entry of new technological infrastructures into the financial markets poses serious concerns about the misuse of the economic system for illicit purposes, such as money laundering and financing of terrorism. Although there are cases in which this connection has already been discovered by malicious actors, distributed ledger technologies can nevertheless represent a powerful tool at the disposal of competent authorities to trace illicit flows and to better monitor risks in financial markets. However, this possibility may go through an interdisciplinary analysis of the phenomena. The search for alternative systems to move funds, rather than the traditional financial intermediaries, such as banks, is not a new circumstance and not necessarily for criminal purposes. Nevertheless, some of the already-known value transfer systems may benefit from the use of distributed ledger technology and make their detection more difficult. The European institutions are discussing the needed legislative packages to enforce the current regulations and to extend their application to the crypto space, as well as the establishment of a new competent authority.
Published: 2024

30. Data-driven background model for the CUORE experiment

Author: CUORE Collaboration, Adams, D. Q., Alduino, C., Alfonso, K., Avignone III, F. T., Azzolini, O., Bari, G., Bellini, F., Benato, G., Beretta, M., Biassoni, M., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Caminata, A., Campani, A., Cao, J., Capelli, S., Capelli, C., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chiesa, D., Clemenza, M., Cremonesi, O., Creswick, R. J., D'Addabbo, A., Dafinei, I., Del Corso, F., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompè, V., Fang, D. Q., Fantini, G., Faverzani, M., Ferri, E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Ghislandi, S., Giachero, A., Girola, M., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Keppel, G., Kolomensky, Yu. G., Kowalski, R., Liu, R., Ma, L., Ma, Y. G., Marini, L., Maruyama, R. H., Mayer, D., Mei, Y., Moore, M. N., Napolitano, T., Nastasi, M., Nones, C., Norman, E. B., Nucciotti, A., Nutini, I., O'Donnell, T., Olmi, M., Oregui, B. T., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Ponce, I., Pottebaum, E. G., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rosenfeld, C., Schmidt, B., Sharma, V., Singh, V., Sisti, M., Speller, D., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, J. A, Vetter, K. J., Vignati, M., Wagaarachchi, S. L., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Zimmermann, S., and Zucchelli, S.
Subjects: Nuclear Experiment, Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract: We present the model we developed to reconstruct the CUORE radioactive background based on the analysis of an experimental exposure of 1038.4 kg yr. The data reconstruction relies on a simultaneous Bayesian fit applied to energy spectra over a broad energy range. The high granularity of the CUORE detector, together with the large exposure and extended stable operations, allow for an in-depth exploration of both spatial and time dependence of backgrounds. We achieve high sensitivity to both bulk and surface activities of the materials of the setup, detecting levels as low as 10 nBq kg$^{-1}$ and 0.1 nBq cm$^{-2}$, respectively. We compare the contamination levels we extract from the background model with prior radio-assay data, which informs future background risk mitigation strategies. The results of this background model play a crucial role in constructing the background budget for the CUPID experiment as it will exploit the same CUORE infrastructure.
Published: 2024
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31. Searching for Beyond the Standard Model physics using the improved description of $^{100}$Mo $2\nu\beta\beta$ decay spectral shape with CUPID-Mo

Author: Augier, C., Barabash, A. S., Bellini, F., Benato, G., Beretta, M., Bergé, L., Billard, J., Borovlev, Yu. A., Cardani, L., Casali, N., Cazes, A., Celi, E., Chapellier, M., Chiesa, D., Dafinei, I., Danevich, F. A., De Jesus, M., Dixon, T., Dumoulin, L., Eitel, K., Ferri, F., Fujikawa, B. K., Gascon, J., Gironi, L., Giuliani, A., Grigorieva, V. D., Gros, M., Helis, D. L., Huang, H. Z., Huang, R., Imbert, L., Juillard, A., Khalife, H., Kleifges, M., Kobychev, V. V., Kolomensky, Yu. G., Konovalov, S. I., Kotila, J., Loaiza, P., Ma, L., Makarov, E. P., de Marcillac, P., Mariam, R., Marini, L., Marnieros, S., Navick, X. F., Nones, C., Norman, E. B., Olivieri, E., Ouellet, J. L., Pagnanini, L., Pattavina, L., Paul, B., Pavan, M., Peng, H., Pessina, G., Pirro, S., Poda, D. V., Polischuk, O. G., Pozzi, S., Previtali, E., Redon, Th., Rojas, A., Rozov, S., Sanglard, V., Scarpaci, J. A., Schmidt, B., Shen, Y., Shlegel, V. N., Šimkovic, F., Singh, V., Tomei, C., Tretyak, V. I., Umatov, V. I., Vagneron, L., Velázquez, M., War, B., Welliver, B., Winslow, L., Xue, M., Yakushev, E., Zarytskyy, M., and Zolotarova, A. S.
Subjects: Nuclear Experiment
Abstract: The current experiments searching for neutrinoless double-$\beta$ ($0\nu\beta\beta$) decay also collect large statistics of Standard Model allowed two-neutrino double-$\beta$ ($2\nu\beta\beta$) decay events. These can be used to search for Beyond Standard Model (BSM) physics via $2\nu\beta\beta$ decay spectral distortions. $^{100}$Mo has a natural advantage due to its relatively short half-life, allowing higher $2\nu\beta\beta$ decay statistics at equal exposures compared to the other isotopes. We demonstrate the potential of the dual read-out bolometric technique exploiting a $^{100}$Mo exposure of 1.47 kg $\times$ y, acquired in the CUPID-Mo experiment at the Modane underground laboratory (France). We set limits on $0\nu\beta\beta$ decays with the emission of one or more Majorons, on $2\nu\beta\beta$ decay with Lorentz violation, and $2\nu\beta\beta$ decay with a sterile neutrino emission. In this analysis, we investigate the systematic uncertainty induced by modeling the $2\nu\beta\beta$ decay spectral shape parameterized through an improved model, an effect never considered before. This work motivates searches for BSM processes in the upcoming CUPID experiment, which will collect the largest amount of $2\nu\beta\beta$ decay events among the next-generation experiments.
Published: 2024

32. With or without $\nu$? Hunting for the seed of the matter-antimatter asymmetry

Author: CUORE Collaboration, Adams, D. Q., Alduino, C., Alfonso, K., Avignone III, F. T., Azzolini, O., Bari, G., Bellini, F., Benato, G., Beretta, M., Biassoni, M., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Caminata, A., Campani, A., Cao, J., Capelli, S., Capelli, C., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chiesa, D., Clemenza, M., Cremonesi, O., Creswick, R. J., D'Addabbo, A., Dafinei, I., Del Corso, F., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompè, V., Fang, D. Q., Fantini, G., Faverzani, M., Ferri, E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Ghislandi, S., Giachero, A., Girola, M., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Keppel, G., Kolomensky, Yu. G., Kowalski, R., Liu, R., Ma, L., Ma, Y. G., Marini, L., Maruyama, R. H., Mayer, D., Mei, Y., Moore, M. N., Napolitano, T., Nastasi, M., Nones, C., Norman, E. B., Nucciotti, A., Nutini, I., O'Donnell, T., Olmi, M., Oregui, B. T., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Ponce, I., Pottebaum, E. G., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rosenfeld, C., Schmidt, B., Sharma, V., Singh, V., Sisti, M., Speller, D., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, J. A, Vetter, K. J., Vignati, M., Wagaarachchi, S. L., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Zimmermann, S., and Zucchelli, S.
Subjects: Nuclear Experiment
Abstract: The matter-antimatter asymmetry underlines the incompleteness of the current understanding of particle physics. Neutrinoless double-beta ($0\nu \beta\beta$) decay may help explain this asymmetry, while unveiling the Majorana nature of the neutrino. The CUORE experiment searches for $0\nu \beta\beta$ decay of $^{130}$Te using a tonne-scale cryogenic calorimeter operated at milli-kelvin temperatures. We report no evidence for $0\nu \beta\beta$ decay and place a lower limit on the half-life of T$_{1/2}$ $>$ 3.8 $\times$ 10$^{25}$ years (90% C.I.) with over 2 tonne$\cdot$year TeO$_2$ exposure. The tools and techniques developed for this result and the 5 year stable operation of nearly 1000 detectors demonstrate the infrastructure for a next-generation experiment capable of searching for $0\nu \beta\beta$ decay across multiple isotopes.
Published: 2024

33. Learning Alternative Ways of Performing a Task

Author: Nieves, David, Ramírez-Quintana, María José, Monserrat, Carlos, Ferri, César, and Hernández-Orallo, José
Subjects: Computer Science - Artificial Intelligence, I.2.6, I.5.4
Abstract: A common way of learning to perform a task is to observe how it is carried out by experts. However, it is well known that for most tasks there is no unique way to perform them. This is especially noticeable the more complex the task is because factors such as the skill or the know-how of the expert may well affect the way she solves the task. In addition, learning from experts also suffers of having a small set of training examples generally coming from several experts (since experts are usually a limited and expensive resource), being all of them positive examples (i.e. examples that represent successful executions of the task). Traditional machine learning techniques are not useful in such scenarios, as they require extensive training data. Starting from very few executions of the task presented as activity sequences, we introduce a novel inductive approach for learning multiple models, with each one representing an alternative strategy of performing a task. By an iterative process based on generalisation and specialisation, we learn the underlying patterns that capture the different styles of performing a task exhibited by the examples. We illustrate our approach on two common activity recognition tasks: a surgical skills training task and a cooking domain. We evaluate the inferred models with respect to two metrics that measure how well the models represent the examples and capture the different forms of executing a task showed by the examples. We compare our results with the traditional process mining approach and show that a small set of meaningful examples is enough to obtain patterns that capture the different strategies that are followed to solve the tasks., Comment: 32 pages, Github repository, published paper, authors' version
Published: 2024
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34. Cell Motility in Cancer, Crucial Events, Criticality, and L\'{e}vy Walks

Author: Shah, Yawer H., Palatella, Luigi, Mahmoodi, Korosh, Santonocito, Orazio S., Morelli, Mariangela, Ferri, Gianmarco, Mazzanti, Chiara M., Grigolini, Paolo, and West, Bruce J.
Subjects: Nonlinear Sciences - Adaptation and Self-Organizing Systems
Abstract: The analysis of glioblastoma (GB) cell locomotion and its modeling inspired by Levy random walks is presented herein. We study such walks occurring on a two-dimensional plane where the walk is similar to the motion of a bird flying with a constant velocity, but with random changes of direction in time. The intelligence of the bird is signaled by the instantaneous changes of flying direction, which become invisible in the time series obtained by projecting the 2D walk either on the x axis or the y axis. We establish that the projected 1D time series share the statistical complexity of time series frequently used to monitor physiological processes, shedding light on the role of crucial events (CE-s) in pathophysiology. Such CE-s are signified by abrupt changes of flying direction which are invisible in the 1D physiological time series. We establish a connection between the complex scaling index \delta generated by the CE-s through \mu_{R} = 2 - \delta , where \mu_{R} is the inverse power law index of the probability density function of the time interval between consecutive failures of the process of interest. We argue that the identification of empirical indices along with their theoretical relations afford important measures to control cancer., Comment: 30 pages, 44 references, 13 figures
Published: 2024

35. Nonlinear Behavior of Josephson Traveling Wave Parametric Amplifiers

Author: Guarcello, Claudio, Ahrens, Felix, Avallone, Guerino, Barone, Carlo, Borghesi, Matteo, Callegaro, Luca, Carapella, Giovanni, Caricato, Anna Paola, Carusotto, Iacopo, Cian, Alessandro, D'Elia, Alessandro, Di Gioacchino, Daniele, Enrico, Emanuele, Falferi, Paolo, Fasolo, Luca, Faverzani, Marco, Ferri, Elena, Filatrella, Giovanni, Gatti, Claudio, Giachero, Andrea, Giubertoni, Damiano, Granata, Veronica, Leo, Angelo, Labranca, Danilo, Ligi, Carlo, Maccarrone, Giovanni, Mantegazzini, Federica, Margesin, Benno, Maruccio, Giuseppe, Mezzena, Renato, Monteduro, Anna Grazia, Moretti, Roberto, Nucciotti, Angelo, Oberto, Luca, Origo, Luca, Komnang, Alex Stephane Piedjou, Pagano, Sergio, Piersanti, Luca, Rettaroli, Alessio, Rizzato, Silvia, Tocci, Simone, Vinante, Andrea, and Zannoni, Mario
Subjects: Condensed Matter - Superconductivity, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract: Recent advancements in quantum technologies and advanced detection experiments have underscored the pressing need for the detection of exceedingly weak signals within the microwave frequency spectrum. Addressing this challenge, the Josephson Traveling Wave Parametric Amplifier (JTWPA) has been proposed as a cryogenic front-end amplifier capable of approaching the quantum noise limit while providing a relevant bandwidth. This research is centered on a comprehensive numerical investigation of the JTWPA, without resorting to simplifications regarding the nonlinearity of the essential components. Specifically, this study focuses on a thorough examination of the system, characterized by coupled nonlinear differential equations representing all components of the device. Proper input and output signals at the device's boundaries are considered. The analysis of the output signals undergoing the parametric amplification process involves a detailed exploration of phase-space dynamics and Fourier spectral analysis of the output voltage. This study is conducted while considering the parameters ruling the response of the device under pump and signal excitations. In addition to the expected signal amplification, the findings reveal that the nonlinear nature of the system can give rise to unforeseen phenomena, depending on the system's operational conditions, which include: the generation of pump tone harmonics, modulation of the signal gain, and incommensurate frequency generation-effects that are not easily accommodated by simplistic linearized approaches, Comment: 5 pages, 4 figures, DARTWARS project - INFN (Italy)
Published: 2024
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36. Progressive cardiomyopathy with intercalated disc disorganization in a rat model of Becker dystrophy

Author: Taglietti, Valentina, Kefi, Kaouthar, Mirciloglu, Busra, Bastu, Sultan, Masson, Jean-Daniel, Bronisz-Budzyńska, Iwona, Gouni, Vassiliki, Ferri, Carlotta, Jorge, Alan, Gentil, Christel, Pietri-Rouxel, France, Malfatti, Edoardo, Lafuste, Peggy, Tiret, Laurent, and Relaix, Frederic
Published: 2024
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37. Cost-effectiveness of robotic vs laparoscopic distal pancreatectomy. Results from the national prospective trial ROBOCOSTES

Author: Guerrero-Ortiz, María Alejandra, Sánchez-Velazquez, Patricia, Burdío, Fernando, Gimeno, Marta, Podda, Mauro, Pellino, Gianluca, Toledano, Miguel, Nuñez, Javier, Bellido, Juan, Acosta-Mérida, María Asunción, Vicente, Emilio, Lopez-Ben, Santiago, Pacheco, David, Pando, Elizabeth, Jorba, Rosa, Trujillo, Juan Pablo Arjona, Ausania, Fabio, Alvarez, Mario, Fernandes, Nair, Castro-Boix, Sandra, Gantxegi, Amaia, Carré, Miquel Kraft-, Pinto-Fuentes, Pilar, Bueno-Cañones, Alejandro, Valdes-Hernandez, Javier, Tresierra, Luis, Caruso, Riccardo, Ferri, Valentina, Tio, Berta, Babiloni-Simon, Sonia, Lacasa-Martin, David, González-Abós, Carolina, Guevara-Martinez, Jenny, Gutierrez-Iscar, Eduardo, Sanchez-Santos, Raquel, Cano-Valderrama, Oscar, Nogueira-Sixto, Manuel, Alvarez-Garrido, Nicolas, Martinez-Cortijo, Sagrario, Lasaia, Manuel Alberto, Linacero, Santiago, Morante, Ana Pilar, Rotellar, Fernando, Arredondo, Jorge, Marti, Pablo, Sabatella, Lucas, Zozaya, Gabriel, and Ielpo, Benedetto
Published: 2024
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38. Forensic species identification: practical guide for animal and plant DNA analysis

Author: Corradini, Beatrice, Gianfreda, Denise, Ferri, Gianmarco, Ferrari, Francesca, Borciani, Ilaria, Santunione, Anna Laura, and Cecchi, Rossana
Published: 2024
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39. Anti-CFH-associated hemolytic uremic syndrome: do we still need plasma exchange?

Author: Ferri, Marion, Zotta, Federica, Donadelli, Roberta, Dossier, Claire, Duneton, Charlotte, El-Sissy, Carine, Fremeau-Bacchi, Véronique, Kwon, Thérésa, Quadri, Lisa, Pasini, Andrea, Sellier-Leclerc, Anne-Laure, Vivarelli, Marina, and Hogan, Julien
Published: 2024
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40. Outcomes after revisional surgery for paraesophageal hernias at a high-volume tertiary care center

Author: Kammili, Anitha, Trépanier, Maude, Cools-Lartigue, Jonathan, Ferri, Lorenzo E., and Mueller, Carmen L.
Published: 2024
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41. Larger and more instructable language models become less reliable

Author: Zhou, Lexin, Schellaert, Wout, Martínez-Plumed, Fernando, Moros-Daval, Yael, Ferri, Cèsar, and Hernández-Orallo, José
Published: 2024
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42. Clinical and Humanistic Burden of Non-inhibitor Haemophilia A in Five European Countries: Insights from the CHESS II Study

Author: Ferri Grazzi, Enrico, Becker, Tobias, Brandt, Stephanie, Duport, Gaetan, Garcia Diego, Daniel-Anibal, Lupi, Angelo, McKeown, William, Morgan, Debra, Camp, Charlotte, Hawes, Charles, Blenkiron, Tom, O’Hara, Jamie, and Burke, Tom
Published: 2024
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43. Video head impulse test in subacute and chronic stroke survivors: new perspectives for implementation of assessment in rehabilitation

Author: Tramontano, Marco, Ferri, Nicola, Turolla, Andrea, Orejel Bustos, Amaranta Soledad, Casagrande Conti, Laura, Sorge, Chiara, Pillastrini, Paolo, and Manzari, Leonardo
Published: 2024
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44. Management of Renovascular Hypertension and Renal Denervation in Patients with Hypertension: An Italian Nationwide Survey

Author: Pappaccogli, Marco, Ponsa, Lara, Goi, Jessica, Burrello, Jacopo, Di Dalmazi, Guido, Cicero, Arrigo Francesco Giuseppe, Mancusi, Costantino, Moia, Elena Coletti, Iaccarino, Guido, Borghi, Claudio, Muiesan, Maria Lorenza, Ferri, Claudio, Rabbia, Franco, and Mulatero, Paolo
Published: 2024
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45. NIV-NAVA versus non-invasive respiratory support in preterm neonates: a meta-analysis of randomized controlled trials

Author: Tomé, Milena R., Orlandin, Eduardo A. de S., Zinher, Mariana T., Dias, Sofia O., Gonçalves-Ferri, Walusa A., De Luca, Daniele, and Iwashita-Lages, Thaís
Published: 2024
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46. Platelet lysate for the treatment of osteoarthritis: a systematic review of preclinical and clinical studies

Author: Valtetsiotis, K., Di Martino, A., Brunello, M., D’Agostino, C., Poluzzi, R., Ferri, R., Mora, P., Traina, F., and Faldini, C.
Published: 2024
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47. Influence of Neoadjuvant Immunotherapy–Chemotherapy on Perioperative Outcomes in Locally Advanced Esophageal Adenocarcinoma

Author: Nevo, Yehonatan, Tankel, James, Zhao, Hedi, Ramirez, Jaime, Cools-Lartigue, Jonathan, Muller, Carmen, Alcindor, Thierry, and Ferri, Lorenzo
Published: 2024
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48. Influence on marginal bone levels at implants equipped with blades aiming to control the lateral pressure on the cortical bone. An experimental study in dogs

Author: Kanayama, Masatsugu, Ferri, Mauro, Guzon, Fernando M. Muñoz, Asano, Akihisa, Alccayhuaman, Karol Alí Apaza, Rossi, Ermenegildo Federico De, and Botticelli, Daniele
Published: 2024
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49. Psychometric properties of the Patient Dignity Inventory in an acute psychiatric ward: an extension study of the preliminary validation

Author: Di Lorenzo R, Ferri P, Biffarella C, Cabri G, Carretti E, Pollutri G, Spattini L, Del Giovane C, and Chochinov HM
Subjects: Dignity perception in psychiatry. Patient Dignity Inventory (PDI), Patients hospitalized in an acute psychiatric ward, Severe psychiatric diseases, Validation study, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract: Rosaria Di Lorenzo,1 Paola Ferri,2 Carlotta Biffarella,2 Giulio Cabri,3 Eleonora Carretti,4 Gabriella Pollutri,5 Ludovica Spattini,5 Cinzia Del Giovane,6 Harvey Max Chochinov7 1Psychiatric Intensive Treatment Facility, Mental Health Department, Azienda USL, Modena, Italy; 2Department of Diagnostic, Clinical and Public Health Medicine, University of Modena and Reggio Emilia, Modena, Italy; 3Service of Psychiatric Diagnosis and Treatment, Mental Health Department, Azienda USL, Modena, Italy; 4School of Nursing, University of Modena and Reggio Emilia, Italy; 5School of Specialization in Pscyhiatry, Faculty of Medicine, University of Modena and Reggio Emilia, Italy; 6Faculty of Medicine, Institute of Primary Care (BIHAM), University of Bern, Bern, Switzerland; 7Department of Psychiatry, University of Manitoba, Winnipeg, MB, Canada Background: During the last decades, dignity has been an emerging issue in mental health since its ethical and therapeutic implications became known. This study is an extension of the preliminary validation of the Patient Dignity Inventory (PDI) in a psychiatric setting, originally designed for assessing perceived dignity in terminal cancer patients. Methods: From October 21, 2015 to December 31, 2016, we administered the Italian PDI to all patients hospitalized in an acute psychiatric ward, who provided their consent and completed it at discharge (n=165). We performed Cronbach’s alpha coefficient and principal factor analysis. We administered other scales concomitantly to analyze the concurrent validity of PDI. We applied stepwise multiple linear regression to identify the patients’ demographic and clinical variables related to the PDI score. Results: Our response rate was 93%, with excellent internal consistency (Cronbach’s alpha coefficient=0.94). The factorial analysis showed three factors with eigenvalue >1, which explained >80% of total variance: 1) “loss of self-identity and anxiety for the future”, 2) “concerns for social dignity and spiritual life”, and 3) “loss of personal autonomy”. The PDI and the three factor scores were positively and significantly correlated with the Hamilton Scales for Depression and Anxiety but not with other scale scores. Among patients’ variables, “suicide risk” and “insufficient social and economic condition” were positively and significantly correlated with the PDI total score. Conclusion: The PDI can be a reliable tool to assess patients’ dignity perception in a psychiatric setting, which suggests that both social and clinical severe conditions are closely related to dignity loss. Keywords: dignity perception in psychiatry, patient dignity inventory, patients hospitalized in an acute psychiatric ward, severe psychiatric diseases, suicide risk, insufficient social and economic condition
Published: 2018

50. On the number of quaternion and dihedral braces and Hopf--Galois structures

Author: Byott, Nigel P. and Ferri, Fabio
Subjects: Mathematics - Rings and Algebras, Mathematics - Group Theory, Mathematics - Number Theory, 20N99 (Primary) 16T05, 12F10, 16T25 (Secondary)
Abstract: We prove a conjecture of Guarnieri and Vendramin on the number of braces of a given order whose multiplicative group is a generalised quaternion group. At the same time, we give a similar result where the multiplicative group is dihedral. We also enumerate Hopf-Galois structures of abelian type on Galois extensions with generalised quaternion or dihedral Galois group., Comment: 25 pages. Additional references included
Published: 2024

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