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3 results on '"Ferreras, Lorena Lopez"'

1. Glucagon-Like Peptide-1 and its Analogues Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight

Author

Anderberg, Rozita H, Richard, Jennifer E, Eerola, Kim, Ferreras, Lorena Lopez, Nordbeck, Elin Banke, Hansson, Caroline, Nissbrandt, Hans, Berqquist, Filip, Gribble, Fiona M, Reimann, Frank, Wernstedt-Asterholm, Ingrid, Lamy, Christophe M., Skibicka, Karolina P, Gribble, Fiona [0000-0002-4232-2898], Reimann, Frank [0000-0001-9399-6377], and Apollo - University of Cambridge Repository

Subjects
endocrine system, obesity, food intake, Exendin-4, digestive, oral, and skin physiology, GLP-1, hormones, hormone substitutes, and hormone antagonists, serotonin
Abstract

Glucagon-like peptide-1 (GLP-1) and serotonin play critical roles in energy balance regulation. Both systems are exploited clinically as anti-obesity strategies. Surprisingly whether they interact in order to regulate energy balance is poorly understood. Here we investigated mechanisms by which GLP-1 and serotonin interact at the level of the CNS. Serotonin depletion impaired the ability of exendin-4, a clinically utilized GLP-1 analogue, to reduce body weight in rats, suggesting serotonin is a critical mediator of the energy balance impact of GLP-1R activation. Serotonin turnover and expression of 5HT2A and 5HT2C serotonin receptors in the hypothalamus were altered by GLP-1R activation. We demonstrate that 5HT2A, but surprisingly not 5HT2C, receptor is critical for weight-loss, anorexia and fat mass reduction induced by central GLP-1R activation. Importantly, central 5HT2A receptors are also required for peripherally injected liraglutide to reduce feeding and weight. Dorsal raphe (DR) harbors cell bodies of serotonin producing neurons that supply serotonin to the hypothalamic nuclei. We show that GLP-1R stimulation in DR is sufficient to induce hypophagia and increase electrical activity of the DR serotonin neurons. Finally our results disassociate brain metabolic and emotionality pathways impacted by GLP-1R activation. This study identifies serotonin as new critical neural substrate for GLP-1 impact on energy homeostasis, and expands the current map of brain areas impacted by GLP-1R activation.

Published
2017
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2. Glucagon-Like Peptide 1 and Its Analogs Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight.

Author

Anderberg, Rozita H., Richard, Jennifer E., Eerola, Kim, López-Ferreras, Lorena, Banke, Elin, Hansson, Caroline, Nissbrandt, Hans, Berqquist, Filip, Gribble, Fiona M., Reimann, Frank, Asterholm, Ingrid Wernstedt, Lamy, Christophe M., Skibicka, Karolina P., Ferreras, Lorena Lopez, Nordbeck, Elin Banke, Wernstedt-Asterholm, Ingrid, and Lamy, Christophe

Subjects
PEPTIDES, SEROTONIN, BIOENERGETICS, ANTIOBESITY agents, APPETITE loss, BODY weight, HOMEOSTASIS, AMINOPYRIDINES, ANIMAL experimentation, ANOREXIA nervosa, APPETITE, BRAIN stem, CELL receptors, FOOD habits, HETEROCYCLIC compounds, HYPOGLYCEMIC agents, PHENYLALANINE, RATS, RESEARCH funding, SEROTONIN antagonists, VENOM, WEIGHT loss, GLUCAGON-like peptide 1, INDOLE compounds, PHARMACODYNAMICS
Abstract

Glucagon-like peptide 1 (GLP-1) and serotonin play critical roles in energy balance regulation. Both systems are exploited clinically as antiobesity strategies. Surprisingly, whether they interact in order to regulate energy balance is poorly understood. Here we investigated mechanisms by which GLP-1 and serotonin interact at the level of the central nervous system. Serotonin depletion impaired the ability of exendin-4, a clinically used GLP-1 analog, to reduce body weight in rats, suggesting that serotonin is a critical mediator of the energy balance impact of GLP-1 receptor (GLP-1R) activation. Serotonin turnover and expression of 5-hydroxytryptamine (5-HT) 2A (5-HT2A) and 5-HT2C serotonin receptors in the hypothalamus were altered by GLP-1R activation. We demonstrate that the 5-HT2A, but surprisingly not the 5-HT2C, receptor is critical for weight loss, anorexia, and fat mass reduction induced by central GLP-1R activation. Importantly, central 5-HT2A receptors are also required for peripherally injected liraglutide to reduce feeding and weight. Dorsal raphe (DR) harbors cell bodies of serotonin-producing neurons that supply serotonin to the hypothalamic nuclei. We show that GLP-1R stimulation in DR is sufficient to induce hypophagia and increase the electrical activity of the DR serotonin neurons. Finally, our results disassociate brain metabolic and emotionality pathways impacted by GLP-1R activation. This study identifies serotonin as a new critical neural substrate for GLP-1 impact on energy homeostasis and expands the current map of brain areas impacted by GLP-1R activation. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

3. Glucagon-like peptide-1 and its analogues act in the dorsal raphe and modulate central serotonin to reduce appetite and body weight

Author

Anderberg, Rozita H, Richard, Jennifer E, Eerola, Kim, Ferreras, Lorena Lopez, Nordbeck, Elin Banke, Hansson, Caroline, Nissbrandt, Hans, Berqquist, Filip, Gribble, Fiona M, Reimann, Frank, Wernstedt-Asterholm, Ingrid, Lamy, Christophe M., Skibicka, Karolina P, Anderberg, Rozita H, Richard, Jennifer E, Eerola, Kim, Ferreras, Lorena Lopez, Nordbeck, Elin Banke, Hansson, Caroline, Nissbrandt, Hans, Berqquist, Filip, Gribble, Fiona M, Reimann, Frank, Wernstedt-Asterholm, Ingrid, Lamy, Christophe M., and Skibicka, Karolina P

Abstract

Glucagon-like peptide-1 (GLP-1) and serotonin play critical roles in energy balance regulation. Both systems are exploited clinically as anti-obesity strategies. Surprisingly whether they interact in order to regulate energy balance is poorly understood. Here we investigated mechanisms by which GLP-1 and serotonin interact at the level of the CNS. Serotonin depletion impaired the ability of exendin-4, a clinically utilized GLP-1 analogue, to reduce body weight in rats, suggesting serotonin is a critical mediator of the energy balance impact of GLP-1R activation. Serotonin turnover and expression of 5HT2A and 5HT2C serotonin receptors in the hypothalamus were altered by GLP-1R activation. We demonstrate that 5HT2A, but surprisingly not 5HT2C, receptor is critical for weight-loss, anorexia and fat mass reduction induced by central GLP-1R activation. Importantly, central 5HT2A receptors are also required for peripherally injected liraglutide to reduce feeding and weight. Dorsal raphe (DR) harbors cell bodies of serotonin producing neurons that supply serotonin to the hypothalamic nuclei. We show that GLP-1R stimulation in DR is sufficient to induce hypophagia and increase electrical activity of the DR serotonin neurons. Finally our results disassociate brain metabolic and emotionality pathways impacted by GLP-1R activation. This study identifies serotonin as new critical neural substrate for GLP-1 impact on energy homeostasis, and expands the current map of brain areas impacted by GLP-1R activation.

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