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156 results on '"Ferrell, R.E."'

4. Magnetic properties of DyCo10Mo(sub 2-x)Si(sub x) compounds

Author

Zhang, C., Mohanty, R.C., Raman, A., Grenier, C.G., Ferrell, R.E., and Shaheen, S.A.

Subjects
Coordination compounds -- Research, Rare earth metals -- Magnetic properties, Physics
Abstract

Research was conducted to examine the structural and magnetic characteristics of DyCo10Mo(sub 2-x)Si(sub x) compounds. The substitution of Mo and Si for Co in DyCo10Mo(sub 2-x)Si(sub x) yielde the maximum Curie temperature at x = 1.5. The spin reorientation occurring in the compound at low temperature was associated with the change of the easy-magnetization direction from the c axis to a conical arrangement as the temperature was decreased.

Published
1999

6. Genetic characterization of American and Western Samoans

Author

Deka, R., McGarvey, S.T., Ferrell, R.E., Kamboh, M.I., Yu, L.M., Aston, C.E., Jin, L., and Chakraborty, R.

Subjects
Samoa (Nation) -- Demographic aspects, Indigenous peoples -- American Samoa -- Research, Human population genetics -- Research -- Genetic aspects, Samoans -- Genetic aspects -- Research, Biological sciences, Genetic aspects, Research, Demographic aspects
Abstract

The Samoan islands were politically separated into American Samoa and Western Samoa in the early 1900s. Economic modernization is far more extensive in American Samoa. However, the Samoan archipelago has maintained a remarkable degree of sociocultural homogeneity, including intermarriage. The sociocultural exchanges presumably led to genetic homogeneity between the two Samoas. Detailed genetic comparisons and characterizations of Samoans are scanty, however. As part of a multidisciplinary study of modernization and cardiovascular risk factors in adults, we analyzed nine hypervariable nuclear DNA (HVR) and four serum protein polymorphisms in the two Samoan groups. The average heterozygosities at both DNA and serum protein loci are comparable in the two groups. As expected, the HVR loci reveal a high degree of variability (heterozygosity 30-87%) compared with the serum protein loci (heterozygosity 1-52%). A large proportion of alleles at the HVR loci, ranging from 50% to 100%, are shared between American and Western Samoa. With the exceptions of the D1S80 locus in American Samoa and the D13S118 locus in Western Samoa, the genotype distributions at all loci conform to their respective Hardy-Weinberg expectations. Sporadic occurrence of the F13B*2 allele at the F13B locus in Samoans indicates a low level of European admixture because this allele is unique to Europeans. The calculated zero values of kinship coefficients and standard genetic distances indicate minimal population differentiation between the two Samoan groups., Samoans form one of the largest and most culturally distinct communities of Polynesia, and the Samoan islands have long been considered an important center of Polynesian culture. As a result [...]

Published
1994

7. Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas. (Original Article)

Author

Baysal, B.E., Willett-Brozick, J.E., Lawrence, E.C., Drovdlic, C.M., Savul, S.A., McLeod, D.R., Yee, H.A., Brackmann, D.E., Slattery, III, W.H., Myers, E.N., Ferrell, R.E., and Rubinstein, W.S.

Subjects
Tumors -- Identification and classification -- Genetic aspects, Head and neck tumors -- Genetic aspects, Health, Identification and classification, Genetic aspects
Abstract

Background: Paragangliomas are rare and highly heritable tumours of neuroectodermal origin that often develop in the head and neck region. Germline mutations in the mitochondrial complex II genes, SDHB, SDHC, [...]

Published
2002

8. Apolipoprotein polymorphisms in Australian aborigines

Author

Kamboh, M.I., Serjeantson, S.W., and Ferrell, R.E.

Subjects
Human population genetics -- Research, Variation (Biology) -- Genetic aspects, Apolipoproteins -- Analysis, Lipid metabolism -- Genetic aspects, Genetic polymorphisms -- Research, Biochemical variation -- Genetic aspects, Australian aborigines -- Genetic aspects, Physical anthropology -- Genetic aspects
Published
1991

9. Stabilization of iron-rich NdFe(sub 13-x)Be(sub x) compounds

Author

Shaheen, S.A., Grenier, C.G., Ferrell, R.E., Zhang, C., Mohanty, R.C., Murugaiah, A., and Raman, R.

Subjects
Beryllium -- Magnetic properties, Neodymium -- Magnetic properties, Iron compounds -- Magnetic properties, Physics
Abstract

The existence of new pseudo-binary Fe-rich NdFe(sub 13-x)Be(sub x) phase (x = 2,3) with a NaZn(sub 13) type structure is reported. A quantum design SQUID magnetometer is used to measure the magnetic properties in the 5 K-350 K range in fields up to 5.5 T and a vibrating sample magnetometer is used to measure the magnetic ordering temperatures.

Published
2001

10. Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci

Author

Jones, G.T., Tromp, G., Kuivaniemi, H., Gretarsdottir, S., Baas, A.F., Giusti, B., Strauss, E., Hof, F.N. van 't, Webb, T.R., Erdman, R., Ritchie, M.D., Elmore, J.R., Verma, A., Pendergrass, S., Kullo, I.J., Ye, Z., Peissig, P.L., Gottesman, O., Verma, S.S., Malinowski, J., Rasmussen-Torvik, L.J., Borthwick, K.M., Smelser, D.T., Crosslin, D.R., Andrade, M. de, Ryer, E.J., McCarty, C.A., Bottinger, E.P., Pacheco, J.A., Crawford, D.C., Carrell, D.S., Gerhard, G.S., Franklin, D.P., Carey, D.J., Phillips, V.L., Williams, M.J., Wei, W., Blair, R., Hill, A.A., Vasudevan, T.M., Lewis, D.R., Thomson, I.A., Krysa, J., Hill, G.B., Roake, J., Merriman, T.R., Oszkinis, G., Galora, S., Saracini, C., Abbate, R., Pulli, R., Pratesi, C., Saratzis, A., Verissimo, A.R., Bumpstead, S., Badger, S.A., Clough, R.E., Cockerill, G., Hafez, H., Scott, D.J., Futers, T.S., Romaine, S.P., Bridge, K., Griffin, K.J., Bailey, M.A., Smith, A., Thompson, M.M., Bockxmeer, F.M. van, Matthiasson, S.E., Thorleifsson, G., Thorsteinsdottir, U., Blankensteijn, J.D., Teijink, J.A., Wijmenga, C., Graaf, J. de, Kiemeney, L.A.L.M., Lindholt, J.S., Hughes, A., Bradley, D.T., Stirrups, K., Golledge, J., Norman, P.E., Powell, J.T., Humphries, S.E., Hamby, S.E., Goodall, A.H., Nelson, C.P., Sakalihasan, N., Courtois, A., Ferrell, R.E., Eriksson, P., Folkersen, L., Franco-Cereceda, A., Eicher, J.D., Johnson, A.D., Betsholtz, C., Ruusalepp, A., Franzen, O., Schadt, E.E., and Bjorkegren, J.L.

Subjects
Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], cardiovascular system, cardiovascular diseases
Abstract

Contains fulltext : 169744.pdf (Publisher’s version ) (Open Access) RATIONALE: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA. OBJECTIVE: To identify additional AAA risk loci using data from all available genome-wide association studies. METHODS AND RESULTS: Through a meta-analysis of 6 genome-wide association study data sets and a validation study totaling 10 204 cases and 107 766 controls, we identified 4 new AAA risk loci: 1q32.3 (SMYD2), 13q12.11 (LINC00540), 20q13.12 (near PCIF1/MMP9/ZNF335), and 21q22.2 (ERG). In various database searches, we observed no new associations between the lead AAA single nucleotide polymorphisms and coronary artery disease, blood pressure, lipids, or diabetes mellitus. Network analyses identified ERG, IL6R, and LDLR as modifiers of MMP9, with a direct interaction between ERG and MMP9. CONCLUSIONS: The 4 new risk loci for AAA seem to be specific for AAA compared with other cardiovascular diseases and related traits suggesting that traditional cardiovascular risk factor management may only have limited value in preventing the progression of aneurysmal disease.

Published
2017

36. Type 2 diabetes and Native American admixture in the San Luis Valley Mexican-American population

Author

BONILLA, C., PARRA, E.J., SOSNOSKI, D., GULDEN, F., YE, J., HIESTER, K., NORRIS, J., MARSHALL, J., HAMMAN, R., FERRELL, R.E., and SHRIVER, M.D.

Subjects
Native Americans -- Health aspects, Type 2 diabetes -- Demographic aspects, Genetic polymorphisms -- Analysis, Population genetics -- Demographic aspects, Anthropology/archeology/folklore
Abstract

Hispanics show twice the prevalence oftype 2 diabetes (NIDDM) as non-Hispanic whites. The causes of this difference in prevalence remain elusive, but undoubtedly, environmental and genetic risk factors, as well as gene-environment interactions are involved in the observed variation in diabetes risk. Previous studies have shown a remarkable correlation between NIDDM and the percentage of Native American ancestry in several North American populations. This correlation has been explained in terms of the presence of risk alleles of Native American ancestry in these populations. In this study, we have analyzed the pattern and dynamics of admixture in a sample of diabetics and controls from the Hispanic population of San Luis Valley, in Colorado. We have used a panel of diallelic genetic markers showing large frequency differences between European and Native American populations to obtain precise admixture estimates. There is no significant difference in Native American contribution between diabetics (38.5%) and controls (37.8%). We discuss this finding in the light of other available data. We also report the distribution of individual admixture proportions in this sample with respect to diabetes and other relevant phenotypes. Finally, we show the results of a study in which we have analyzed the potential association of a number of candidate gene variants and NIDDM in this Hispanic sample. This research has been supported in part by grants to MDS from the NIHNHGRI (HG02154) and NIH-NIDDK (DK53958).

Published
2001

37. Ancestral Proportions and Admixture Dynamics in Geographically Defined African Americans Living in South Carolina

Author

Parra, E.J., Kittles, R.A., Argyropoulos, G., Pfaff, C.L., Hiester, K., Bonilla, C., Sylvester, N., Parrish-Gause, D., Garvey, W.T., Jin, L., McKeigue, P.M., Kamboh, M.I., Ferrell, R.E., Pollitzer, W.S., and Shriver, M.D.

Subjects
South Carolina -- Demographic aspects, African Americans -- Genetic aspects, Gullah dialect -- Demographic aspects, Human population genetics -- Research, Anthropology/archeology/folklore
Abstract

We analyzed admixture in samples of six different African-American populations from South Carolina: Gullah-speaking Sea Islanders in coastal South Carolina, residents of four counties in the 'Low Country' (Berkeley, Charleston, Colleton, and Dorchester), and persons living in the city of Columbia, located in central South Carolina. We used a battery of highly informative autosomal, mtDNA, and Y-chromosome markers. Two of the autosomal markers (FY and AT3) are linked and lie 22 cM apart on chromosome 1. The results of this study indicate, in accordance with previous historical, cultural, and anthropological evidence, a very low level of European admixture in the Gullah Sea Islanders (m = 3.5 [+ or -] 0.9%). The proportion of European admixture is higher in the Low Country (m ranging between 9.9 [+ or -] 1.8% and 14.0 [+ or -] 1.9%), and is highest in Columbia (m = 17.7 [+ or -] 3.1%). A sex-biased European gene flow and a small Native American contribution to the African-American gene pool are also evident in these data. We studied the pattern of pairwise allelic associations between the FY locus and the nine other autosomal markers in our samples. In the combined sample from the Low Country (N = 548), a high level of linkage disequilibrium was observed between the linked markers, FY and AT3. Additionally, significant associations were also detected between FY and 4 of the 8 unlinked markers, suggesting the existence of significant genetic structure in this population. A continuous gene flow model of admixture could explain the observed pattern of genetic structure. A test conditioning on the overall admixture of each individual showed association of ancestry between the two linked markers (FY and AT3), but not between any of the unlinked markers, as theory predicts. Thus, even in the presence of genetic structure due to continuous gene flow or some other factor, it is possible to differentiate associations due to linkage from spurious associations due to genetic structure. Am J Phys Anthropol 114:18-29, 2001. [C] 2001 Wiley-Liss, Inc. KEY WORDS South Carolina, African Americans, admixture, admixture linkage disequilibrium

Published
2001

39. The dopamine system genes and the risk for substance abuse

Author

Vanyukov, M.M., Maher, B.S., Simkevitz, H.F., Kirisci, L., Ferrell, R.E., Marazita, M.L., Kirillova, G.P., and Tarter, R.E.

Subjects
Genetic research -- Analysis, Human genetics -- Research, Substance abuse -- Genetic aspects, Dopamine -- Genetic aspects, Biological sciences
Published
2000

50. Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.

Author

Gretarsdottir, S., Baas, A.F., Thorleifsson, G., Holm, H., Heijer, M. den, Vries, J.P. de, Kranendonk, S.E., Zeebregts, C.J.A., Sterkenburg, S.M. van, Geelkerken, R.H., Rij, A.M. van, Williams, M.J., Boll, A.P.M., Kostic, J., Jonasdottir, A., Walters, G.B., Masson, G., Sulem, P., Saemundsdottir, J., Mouy, M., Magnusson, K.P., Tromp, G., Elmore, J.B., Sakalihasan, N., Limet, R., Defraigne, J.O., Ferrell, R.E., Ronkainen, A., Ruigrok, Y.M., Wijmenga, C., Grobbee, D.E., Shah, S.H., Granger, C.B., Quyyumi, A.A., Vaccarino, V., Patel, R., Zafari, A.M., Levey, A.I., Austin, H., Girelli, D., Pignatti, P.F., Olivieri, O., Martinelli, N., Malerba, G., Trabetti, E., Becker, L.C., Becker, D.M., Reilly, M.P., Rader, D.J., Mueller, T., Dieplinger, B., Haltmayer, M., Urbonavicius, S., Lindblad, B., Gottsäter, A., Gaetani, E., Pola, R., Wells, P., Rodger, M., Forgie, M., Langlois, N., Corral, J., Vicente, V., Fontcuberta, J., España, F., Grarup, N., Jørgensen, T., Witte, D.R., Hansen, T., Pedersen, O., Aben, K.K.H., Graaf, J. de, Holewijn, S., Folkersen, L., Franco-Cereceda, A., Eriksson, P., Collier, D.A., Stefansson, H., Steinthorsdottir, V., Rafnar, T., Valdimarsson, E.M., Magnadottir, H.B., Sveinbjornsdottir, S., Olafsson, I., Magnusson, M.K., Palmason, R., Haraldsdottir, V., Andersen, K., Onundarson, P.T., Thorgeirsson, G., Kiemeney, L.A.L.M., Powell, J.T., Carey, D.J., Kuivaniemi, H., Lindholt, J.S., Jones, G.T., Blankensteijn, J.D., Gretarsdottir, S., Baas, A.F., Thorleifsson, G., Holm, H., Heijer, M. den, Vries, J.P. de, Kranendonk, S.E., Zeebregts, C.J.A., Sterkenburg, S.M. van, Geelkerken, R.H., Rij, A.M. van, Williams, M.J., Boll, A.P.M., Kostic, J., Jonasdottir, A., Walters, G.B., Masson, G., Sulem, P., Saemundsdottir, J., Mouy, M., Magnusson, K.P., Tromp, G., Elmore, J.B., Sakalihasan, N., Limet, R., Defraigne, J.O., Ferrell, R.E., Ronkainen, A., Ruigrok, Y.M., Wijmenga, C., Grobbee, D.E., Shah, S.H., Granger, C.B., Quyyumi, A.A., Vaccarino, V., Patel, R., Zafari, A.M., Levey, A.I., Austin, H., Girelli, D., Pignatti, P.F., Olivieri, O., Martinelli, N., Malerba, G., Trabetti, E., Becker, L.C., Becker, D.M., Reilly, M.P., Rader, D.J., Mueller, T., Dieplinger, B., Haltmayer, M., Urbonavicius, S., Lindblad, B., Gottsäter, A., Gaetani, E., Pola, R., Wells, P., Rodger, M., Forgie, M., Langlois, N., Corral, J., Vicente, V., Fontcuberta, J., España, F., Grarup, N., Jørgensen, T., Witte, D.R., Hansen, T., Pedersen, O., Aben, K.K.H., Graaf, J. de, Holewijn, S., Folkersen, L., Franco-Cereceda, A., Eriksson, P., Collier, D.A., Stefansson, H., Steinthorsdottir, V., Rafnar, T., Valdimarsson, E.M., Magnadottir, H.B., Sveinbjornsdottir, S., Olafsson, I., Magnusson, M.K., Palmason, R., Haraldsdottir, V., Andersen, K., Onundarson, P.T., Thorgeirsson, G., Kiemeney, L.A.L.M., Powell, J.T., Carey, D.J., Kuivaniemi, H., Lindholt, J.S., Jones, G.T., and Blankensteijn, J.D.

Abstract

Contains fulltext : 88507.pdf (publisher's version ) (Closed access)

Published
2010

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