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Your search keyword '"Ferreira-Dias, G."' showing total 250 results
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250 results on '"Ferreira-Dias, G."'

30. Is mare endometrosis linked to oviduct fibrosis?

Author

Pinto-Bravo, P, primary, Ferreira-Dias, G, additional, Rebordão, M R, additional, Amaral, A, additional, Fernandes, C, additional, Cuello, C, additional, Parrilla, I, additional, Martínez, E, additional, Roberto da Costa, R P, additional, and Skarzynski, D J, additional

Published
2018
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32. Editorial

Author

Ferreira-Dias, G, primary, Mateus, L, additional, Rebordão, MR, additional, da Costa, LL, additional, Rocha, AM, additional, Bettencourt, E, additional, and Carreira, RP, additional

Published
2016
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45. Effect of cytokines and ovarian steroids on equine endometrial function: an in vitro study.

Author

Galvao, A., Valente, L., Skarzynski, D.J., Szostek, A., Piotrowska-Tomala, K., Rebordao, M.R., Mateus, L., Ferreira-Dias, G., Galvao, A., Valente, L., Skarzynski, D.J., Szostek, A., Piotrowska-Tomala, K., Rebordao, M.R., Mateus, L., and Ferreira-Dias, G.

Abstract

1 augustus 2013, Item does not contain fulltext, Regulation of immune-endocrine interactions in the equine endometrium is not fully understood. The aims of the present study were to: (1) investigate the presence of tumour necrosis factor alpha (TNF), interferon gamma (IFNG), Fas ligand (FASLG) and their receptors in the mare endometrium throughout the oestrous cycle; and (2) assess endometrial secretory function (prostaglandins), angiogenic activity and cell viability in response to TNF, oestradiol (E2), progesterone (P4) and oxytocin (OXT). Transcription of TNF and FASLG mRNA increased during the early and late luteal phase (LP), whereas IFNG mRNA increased in late LP. Transcription of the mRNA of both TNF receptors was highest in the mid-LP. All cytokines and receptors were expressed in surface and glandular epithelium, as well as in the stroma. Expression of TNF and its receptor TNFRSF1A increased during the follicular phase (FP) and mid-LP. IFNG was expressed in the mid-LP, whereas its receptor IFNR1 was expressed in the in mid- and late LP. The highest expression of FASLG and FAS occurred during the late LP. OXT increased the secretion of prostaglandin (PG) E2 and PGF2alpha in the FP and mid-LP. In the mid-LP, E2 and P4+E2 stimulated PGF2alpha secretion, whereas TNF and P4 increased cell viability. All treatments, with the exception of P4, increased nitric oxide and angiogenic activity in both phases. The coordinated action of cytokines and ovarian hormones may regulate secretory, angiogenic and proliferative functions in the equine endometrium.

Published
2013

50. Oestrous cycle-dependent expression of Fas and Bcl2 family gene products in normal canine endometrium.

Author

Henriques, S., Silva, E., Cruz, S., Silva, M. F., Ferreira-Dias, G., Lopes-da-Costa, L., and Mateus, L.

Subjects
FAS proteins, ESTRUS, ENDOMETRIUM, CELL proliferation, GENE expression in mammals, POLYMERASE chain reaction, IMMUNOHISTOCHEMISTRY, MAMMALS
Abstract

During the oestrous cycle canine endometrium undergoes cyclical cellular proliferation, apoptosis and differentiation. To study the regulation of endometrial apoptosis and proliferation events the expression of apoptosisrelated genes was analysed by real-time polymerase chain reaction and cellular expression of their proteins was identified through immunohistochemistry. Cellular apoptosis and proliferation events were detected by TdT-mediated dUTP-biotin nick end labeling (TUNEL) and proliferation marker Ki67 immunostaining, respectively. The highest proliferative index was observed in the follicular phase (all endometrial cellular components) and at early dioestrus (basal glands). This was associated with a low apoptotic index and a strong expression of anti- (Bcl2) and pro-apoptotic proteins (Fas, FasL, Bax). Subsequently (Days 11-45 of dioestrus), basal glandular epithelium experienced the highest apoptotic index, coincidental with a decrease of Bcl2 expression and a low ratio of Bcl2/Bax transcription. An increase in the apoptotic index of crypts, stromal and endothelial cells was observed at late dioestrus and the beginning of anoestrus. These results indicate that proand anti-apoptotic proteins regulate the balance between cell proliferation and death in the canine endometrium during the oestrous cycle. High Bcl2 expression in both the follicular and early dioestrous phases stimulate glandular proliferation and prevent apoptosis but, in the non-pregnant uterus, a decrease in Bcl2 expression together with an increase in proapoptotic proteins induces apoptosis of basal glandular epithelium cells. [ABSTRACT FROM AUTHOR]

Published
2016
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