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9. Static Postural Control of the Ankle During the Leg Stance Test in Subjects with and Without Chronic Ankle Instability

Author

Ferreira, Diana, Castro, Maria António, Esteves, José, Lovell, Nigel H., Advisory Editor, Oneto, Luca, Advisory Editor, Piotto, Stefano, Advisory Editor, Rossi, Federico, Advisory Editor, Samsonovich, Alexei V., Advisory Editor, Babiloni, Fabio, Advisory Editor, Liwo, Adam, Advisory Editor, Magjarevic, Ratko, Advisory Editor, Martins Amaro, Ana, editor, Roseiro, Luis, editor, Messias, Ana Lúcia, editor, Gomes, Beatriz, editor, Almeida, Henrique, editor, António Castro, Maria, editor, Neto, Maria Augusta, editor, de Fátima Paulino, Maria, editor, and Maranha, Vítor, editor

Published
2023
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10. Recommendation of Medical Exams to Support Clinical Diagnosis Based on Patient’s Symptoms

Author

Neto, Cristiana, Ferreira, Diana, Cunha, Hugo, Pires, Maria, Marques, Susana, Sousa, Regina, Machado, José, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin, Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Machado, José Manuel, editor, and Peixoto, Hugo, editor

Published
2023
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21. Classification of Dementia in Adults

Author

Neto, Cristiana, Ferreira, Diana, Nunes, João, Braga, Luís, Martins, Luís, Cunha, Luís, Machado, José, Howlett, Robert J., Series Editor, Jain, Lakhmi C., Series Editor, Rocha, Álvaro, editor, Fajardo-Toro, Carlos Hernan, editor, and Rodríguez, José María Riola, editor

Published
2022
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22. Detecting Autism Spectrum Disorder Using Data Mining

Author

Guisasola, Ana C., Ferreira, Diana, Neto, Cristiana, Abelha, António, Machado, José, Howlett, Robert J., Series Editor, Jain, Lakhmi C., Series Editor, Rocha, Álvaro, editor, Fajardo-Toro, Carlos Hernan, editor, and Rodríguez, José María Riola, editor

Published
2022
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23. Prediction Models for Coronary Heart Disease

Author

Neto, Cristiana, Ferreira, Diana, Ramos, José, Cruz, Sandro, Oliveira, Joaquim, Abelha, António, Machado, José, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Matsui, Kenji, editor, Omatu, Sigeru, editor, Yigitcanlar, Tan, editor, and González, Sara Rodríguez, editor

Published
2022
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25. Mapping Somatosensory Afferent Circuitry to Bone Identifies Neurotrophic Signals Required for Fracture Healing

Author

Xu, Mingxin, primary, Thottappillil, Neelima, additional, Cherief, Masnsen, additional, Li, Zhao, additional, Zhu, Manyu, additional, Xing, Xin, additional, Gomez-Salazar, Mario, additional, Mwirigi, Juliet M., additional, Sankaranarayanan, Ishwarya, additional, Tavares-Ferreira, Diana, additional, Zhang, Chi, additional, Wang, Xue-Wei, additional, Archer, Mary, additional, Guan, Yun, additional, Tower, Robert J., additional, Cahan, Patrick, additional, Price, Theodore J., additional, Clemens, Thomas L., additional, and James, Aaron W., additional

Published
2024
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31. PENSAMENTOS RUMINATIVOS E FUNÇÕES EXECUTIVAS NO AJUSTAMENTO PSICOLÓGICO EM FAMILIARES CUIDADORES DE PACIENTES ONCOLÓGICOS EM CUIDADOS PALIATIVOS

Author

Ferreira, Diana Isabel Freitas, primary, Almeida, Vera Almeida Margarida Seabra de, additional, Gonçalves, Gerly Naylet Macedo, additional, Rocha, José Carlos Ferreirinha, additional, Costa, Sónia Isabel Remondes, additional, Teixeira, Ricardo João, additional, and Leite, Maria Manuela da Silva, additional

Published
2022
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32. Defatted Flaxseed Flour as a New Ingredient for Foodstuffs: Comparative Analysis with Whole Flaxseeds and Updated Composition of Cold-Pressed Oil.

Author

Ferreira, Diana Melo, Machado, Susana, Espírito Santo, Liliana, Nunes, Maria Antónia, Costa, Anabela S. G., Álvarez-Ortí, Manuel, Pardo, José E., Alves, Rita C., and Oliveira, Maria Beatriz P. P.

Abstract

Background: Flaxseeds are functional foods popular in current diets. Cold-pressing is a solvent-free method to extract flaxseed oil, resulting in a by-product—defatted flour. Objectives/Methods: This study compared whole flaxseeds and defatted flour (proximate composition, fatty acids, vitamin E, total phenolics and flavonoids, antioxidant activity, amino acids, and protein quality) and updated the composition of cold-pressed oil (oxidative stability, peroxide value, UV absorbance, colour, fatty acids, vitamin E, total phenolics and flavonoids, and antioxidant activity) to assess the nutritional relevance and potential for food applications of these samples. Results: The flour had higher ash (6% vs. 4%), fibre (36% vs. 34%), protein (28% vs. 16%), phenolics (205 vs. 143 mg gallic acid equivalents/100 g), and antioxidant activity than seeds (p < 0.05), so it should be valued as a novel high-fibre food ingredient with high-quality plant-based protein, as it contains all essential amino acids (106 mg/g) and a high essential amino acids index (112%), with L-tryptophan as the limiting amino acid. The oil, while low in oxidative stability (1.3 h), due to its high polyunsaturated fatty acids sum (75%), mostly α-linolenic acid (57%), contains a significant amount of vitamin E (444 mg/kg), making it a specialty oil best consumed raw. Conclusions: The exploration of the flour as a minimally processed food ingredient highlights its role in supporting food security, circular economy, and sustainability goals, aligning with consumer preferences for natural, low-fat foods. Future research should investigate the bioactivity and shelf-life of the samples, as well as the bioavailability of compounds after digestion. [ABSTRACT FROM AUTHOR]

Published
2024
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33. B cells drive neuropathic pain–related behaviors in mice through IgG–Fc gamma receptor signaling.

Author

Lacagnina, Michael J., Willcox, Kendal F., Boukelmoune, Nabila, Bavencoffe, Alexis, Sankaranarayanan, Ishwarya, Barratt, Daniel T., Zuberi, Younus A., Dayani, Dorsa, Chavez, Melissa V., Lu, Jonathan T., Farinotti, Alex Bersellini, Shiers, Stephanie, Barry, Allison M., Mwirigi, Juliet M., Tavares-Ferreira, Diana, Funk, Geoffrey A., Cervantes, Anna M., Svensson, Camilla I., Walters, Edgar T., and Hutchinson, Mark R.

Subjects
DORSAL root ganglia, PERIPHERAL nerve injuries, IMMUNE complexes, CELL populations, B cells
Abstract

Neuroimmune interactions are essential for the development of neuropathic pain, yet the contributions of distinct immune cell populations have not been fully unraveled. Here, we demonstrate the critical role of B cells in promoting mechanical hypersensitivity (allodynia) after peripheral nerve injury in male and female mice. Depletion of B cells with a single injection of anti-CD20 monoclonal antibody at the time of injury prevented the development of allodynia. B cell–deficient (muMT) mice were similarly spared from allodynia. Nerve injury was associated with increased immunoglobulin G (IgG) accumulation in ipsilateral lumbar dorsal root ganglia (DRGs) and dorsal spinal cords. IgG was colocalized with sensory neurons and macrophages in DRGs and microglia in spinal cords. IgG also accumulated in DRG samples from human donors with chronic pain, colocalizing with a marker for macrophages and satellite glia. RNA sequencing revealed a B cell population in naive mouse and human DRGs. A B cell transcriptional signature was enriched in DRGs from human donors with neuropathic pain. Passive transfer of IgG from injured mice induced allodynia in injured muMT recipient mice. The pronociceptive effects of IgG are likely mediated through immune complexes interacting with Fc gamma receptors (FcγRs) expressed by sensory neurons, microglia, and macrophages, given that both mechanical allodynia and hyperexcitability of dissociated DRG neurons were abolished in nerve-injured FcγR-deficient mice. Consistently, the pronociceptive effects of IgG passive transfer were lost in FcγR-deficient mice. These data reveal that a B cell–IgG–FcγR axis is required for the development of neuropathic pain in mice. Editor's summary: B cells contribute to the pathogenesis of neuropathic pain, but the exact mechanisms remain elusive. Lacagnina et al. report increased immunoglobulin G (IgG) in the dorsal root ganglia (DRGs) of mice after peripheral nerve injury (PNI) and patients with chronic pain. Passive transfer of IgG from injured wild-type mice elicited allodynia in PNI mice without B cells (muMT) that were otherwise protected from allodynia. Mice lacking the Fc gamma receptor (FcγR) were also protected from allodynia, and this receptor was necessary for the development of hyperexcitability in DRG neurons upon PNI. The identified B cell–IgG–FcγR axis could help to develop alternative treatment avenues for neuropathic pain. —Daniela Neuhofer [ABSTRACT FROM AUTHOR]

Published
2024
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34. Pasta Incorporating Olive Pomace: Impact on Nutritional Composition and Consumer Acceptance of a Prototype.

Author

Ferreira, Diana Melo, Oliveira, Bárbara C. C., Barbosa, Carla, Costa, Anabela S. G., Nunes, Maria Antónia, Oliveira, Maria Beatriz P. P., and Alves, Rita C.

Subjects
CIRCULAR economy, OLEIC acid, NUTRITIONAL value, OLIVE oil, FOOD industry
Abstract

The food industry is encouraged to develop new sustainable foodstuffs, and agri-food by-products can serve as valuable ingredients in these formulations. In this work, olive pomace (OP), a by-product of olive oil production, was incorporated as an ingredient in pasta. The changes in the nutritional composition and consumer acceptance were assessed, aiming to scale up the production. OP contains dietary fibre (55%), fat (9%), α-tocopherol (43 mg/kg), and oleic acid (76%) after moisture elimination. For that, the following two drying procedures were tested: 40 °C for 48 h (OP40) and 70 °C for 24 h (OP70). Both samples were sieved to remove the stone pieces. Drying at 70 °C (OP70) was the fastest method, revealed a better nutritional profile than OP40, and was the product selected for the incorporation into the pasta. The enriched pasta, containing 7.5% of OP70, was compared to a control. It showed an improved nutritional value with higher contents of fat, ash, fibre, vitamin E, oleic acid, phenolics, and flavonoids, a composition related to potential health benefits. Consumers appreciated the appearance, colour, shine, and aroma of the obtained pasta, making it a prototype with commercial viability. However, several improvements need to be implemented, namely, at the textural levels. Corrective actions, such as the optimisation of the amount of incorporated OP, the use of other ingredients for flavour masking, and textural adjustments, are advisable, thereby making this product more appealing and accepted by a larger number of consumers. This prototype can be a good approach for the circular economy, environmental sustainability, and food security. [ABSTRACT FROM AUTHOR]

Published
2024
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35. A CRISP-DM Approach for Predicting Liver Failure Cases: An Indian Case Study

Author

Cunha, António F., Ferreira, Diana, Neto, Cristiana, Abelha, António, Machado, José, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Ahram, Tareq Z., editor, Karwowski, Waldemar, editor, and Kalra, Jay, editor

Published
2021
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36. Data Mining Approach to Classify Cases of Lung Cancer

Author

Vieira, Eduarda, Ferreira, Diana, Neto, Cristiana, Abelha, António, Machado, José, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Rocha, Álvaro, editor, Adeli, Hojjat, editor, Dzemyda, Gintautas, editor, Moreira, Fernando, editor, and Ramalho Correia, Ana Maria, editor

Published
2021
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37. Step Towards Predicting Patient Length of Stay in Intensive Care Units

Author

Neto, Cristiana, Pontes, Gabriel, Domente, Alexandru, Reinolds, Francisco, Costa, José, Ferreira, Diana, Machado, José, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Rocha, Álvaro, editor, Adeli, Hojjat, editor, Dzemyda, Gintautas, editor, Moreira, Fernando, editor, and Ramalho Correia, Ana Maria, editor

Published
2021
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38. Prediction Models for Polycystic Ovary Syndrome Using Data Mining

Author

Neto, Cristiana, Silva, Mateus, Fernandes, Mariana, Ferreira, Diana, Machado, José, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, and Antipova, Tatiana, editor

Published
2021
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39. Diagnosis of Diabetic Retinopathy Using Data Mining Classification Techniques

Author

Abreu, Ana, Ferreira, Diana, Neto, Cristiana, Abelha, António, Machado, José, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, and Antipova, Tatiana, editor

Published
2021
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40. Data Mining Approach to Understand the Association Between Mental Disorders and Unemployment

Author

Neto, Cristiana, Rodrigues, Caroline, Mendonça, Emely, Sartori, Laercio, de Pinho, Rafaela, Ferreira, Diana, Abelha, António, Machado, José, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Rocha, Álvaro, editor, Ferrás, Carlos, editor, López-López, Paulo Carlos, editor, and Guarda, Teresa, editor

Published
2021
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41. Data Mining for the Prediction of Fetal Malformation Through Cardiotocography Data

Author

Nogueira, Maria, Ferreira, Diana, Neto, Cristiana, Abelha, António, Machado, José, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Rocha, Álvaro, editor, Ferrás, Carlos, editor, López-López, Paulo Carlos, editor, and Guarda, Teresa, editor

Published
2021
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49. Step Towards Monitoring Intelligent Agents in Healthcare Information Systems

Author

Sousa, Regina, Ferreira, Diana, Abelha, António, Machado, José, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Rocha, Álvaro, editor, Adeli, Hojjat, editor, Reis, Luís Paulo, editor, Costanzo, Sandra, editor, Orovic, Irena, editor, and Moreira, Fernando, editor

Published
2020
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50. Review of Trends in Automatic Human Activity Recognition Using Synthetic Audio-Visual Data

Author

Jesus, Tiago, Duarte, Júlio, Ferreira, Diana, Durães, Dalila, Marcondes, Francisco, Santos, Flávio, Gomes, Marco, Novais, Paulo, Gonçalves, Filipe, Fonseca, Joaquim, Lori, Nicolas, Abelha, António, Machado, José, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Analide, Cesar, editor, Novais, Paulo, editor, Camacho, David, editor, and Yin, Hujun, editor

Published
2020
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