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24 results on '"Ferreira, Anderson Jose"'

2. Cardiac disturbances and changes in tissue cytokine levels in mice fed with a high-refined carbohydrate diet

Author

Bruno, Alexandre Santos, Castor, Renata Gomes Miranda, Berg, Bárbara, dos Reis Costa, Daniela Esteves Ferreira, Monteiro, André Luis Lima, Scalzo, Sérgio, Oliveira, Karla Caroline Marques, Bello, Fernanda Luiza Menezes, Aguiar, Grazielle Cordeiro, Melo, Marcos Barrouin, Santos, Robson Augusto Souza, Bonaventura, Daniella, Guatimosim, Silvia, Castor, Marina Gomes Miranda, Ferreira, Anderson Jose, and Cau, Stefany Bruno Assis

Published
2023
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3. Nanohybrid composed of graphene oxide functionalized with sodium hyaluronate accelerates bone healing in the tibia of rats

Author

Dantas, Paulo César de Lacerda, Martins-Júnior, Paulo Antônio, Coutinho, Danielle Carvalho Oliveira, Andrade, Vanessa Barbosa, Valverde, Thalita Marcolan, Ávila, Erick de Souza, Almeida, Tatiane Cristine Silva, Queiroz-Junior, Celso Martins, Sá, Marcos Augusto, Góes, Alfredo Miranda, Ladeira, Luiz Orlando, Ferreira, Anderson José, and Marques, Leandro Silva

Published
2021
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5. Pollutants and nutrition: Are methylmercury effects on blood pressure and lipoprotein profile comparable to high-fat diet in mice?

Author

Lacerda Leocádio, Paola Caroline, Dias, Ronaldo Pereira, Pinto, Daniel Vieira, Reis, Jonas Martins, Rodrigues Nascimento, José Carlos, Anne de Castro Brito, Gerly, Valença, José Telmo, Jr., Foureaux, Giselle, Ferreira, Anderson José, Windmöller, Cláudia Carvalhinho, Crespo-Lopez, Maria Elena, Santos, Flávia Almeida, Oriá, Reinaldo Barreto, and Alvarez-Leite, Jacqueline I.

Published
2020
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12. Bone Repair Utilizing Carbon Nanotubes

Author

Martins-Júnior, Paulo Antônio, de Sá, Marcos Augusto, Andrade, Vanessa Barbosa, Ribeiro, Heder José, Ferreira, Anderson José, Zucolotto, V., Series editor, and Jorio, Ado, editor

Published
2016
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16. Correlation Between Clinical and Pathological Findings of Liver Injury in 27 Patients With Lethal COVID‐19 Infections in Brazil

Author

Santana, Monique Freire, primary, Guerra, Mateus T., additional, Hundt, Melanie A., additional, Ciarleglio, Maria M., additional, Pinto, Rebecca Augusta de Araújo, additional, Dutra, Bruna Guimarães, additional, Xavier, Mariana Simão, additional, Lacerda, Marcus Vinicius Guimarães, additional, Ferreira, Anderson Jose, additional, Wanderley, David Campos, additional, Borges do Nascimento, Israel Júnior, additional, Araújo, Roberto Ferreira de Almeida, additional, Pinheiro, Sérgio Veloso Brant, additional, Araújo, Stanley de Almeida, additional, Leite, M. Fatima, additional, Ferreira, Luiz Carlos de Lima, additional, Nathanson, Michael H., additional, and Vieira Teixeira Vidigal, Paula, additional

Published
2021
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18. Correlation Between Clinical and Pathological Findings of Liver Injury in 27 Patients With Lethal COVID‐19 Infections in Brazil.

Author

Santana, Monique Freire, Guerra, Mateus T., Hundt, Melanie A., Ciarleglio, Maria M., Pinto, Rebecca Augusta de Araújo, Dutra, Bruna Guimarães, Xavier, Mariana Simão, Lacerda, Marcus Vinicius Guimarães, Ferreira, Anderson Jose, Wanderley, David Campos, Borges do Nascimento, Israel Júnior, Araújo, Roberto Ferreira de Almeida, Pinheiro, Sérgio Veloso Brant, Araújo, Stanley de Almeida, Leite, M. Fatima, Ferreira, Luiz Carlos de Lima, Nathanson, Michael H., and Vieira Teixeira Vidigal, Paula

Subjects
FATTY liver, CORONAVIRUS diseases, COVID-19, LIVER injuries, PATHOLOGICAL physiology, ANGIOTENSIN converting enzyme, ASPARTATE aminotransferase
Abstract

Liver test abnormalities are frequently observed in patients with coronavirus disease 2019 (COVID‐19) and are associated with worse prognosis. However, information is limited about pathological changes in the liver in this infection, so the mechanism of liver injury is unclear. Here we describe liver histopathology and clinical correlates of 27 patients who died of COVID‐19 in Manaus, Brazil. There was a high prevalence of liver injury (elevated alanine aminotransferase and aspartate aminotransferase in 44% and 48% of patients, respectively) in these patients. Histological analysis showed sinusoidal congestion and ischemic necrosis in more than 85% of the cases, but these appeared to be secondary to systemic rather than intrahepatic thrombotic events, as only 14% and 22% of samples were positive for CD61 (marker of platelet activation) and C4d (activated complement factor), respectively. Furthermore, the extent of these vascular findings did not correlate with the extent of transaminase elevations. Steatosis was present in 63% of patients, and portal inflammation was present in 52%. In most cases, hepatocytes expressed angiotensin‐converting enzyme 2 (ACE2), which is responsible for binding and entry of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), even though this ectoenzyme was minimally expressed on hepatocytes in normal controls. However, SARS‐CoV‐2 staining was not observed. Most hepatocytes also expressed inositol 1,4,5‐triphosphate receptor 3 (ITPR3), a calcium channel that becomes expressed in acute liver injury. Conclusion: The hepatocellular injury that commonly occurs in patients with severe COVID‐19 is not due to the vascular events that contribute to pulmonary or cardiac damage. However, new expression of ACE2 and ITPR3 with concomitant inflammation and steatosis suggests that liver injury may result from inflammation, metabolic abnormalities, and perhaps direct viral injury. [ABSTRACT FROM AUTHOR]

Published
2022
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21. Colaboradores

Author

Tavares, Agostinho, Alessi, Alexandre, Pereira, Alexandre Costa, de Moraes, Aline Alexandra Iannoni, Junior, Álvaro Avezum, Ferreira, Anderson José, da Silva, André Luis Ferreira, Colaço, André Luiz, Brandão, Andréa Araujo, Sposito, Andrei Carvalho, de Paiva, Annelise Machado Gomes, Sanjuliani, Antonio Felipe, da Rocha Nogueira, Armando, Guimarães, Armênio Costa, Ribeiro, Arthur Beltrame, de Magalhães Feitosa, Audes Diógenes, Brandão, Ayrton Pires, Massaro, Ayrton Roberto, da Costa, Bartira Ercília Pinheiro, Caramelli, Bruno, Machado, Carlos Alberto, Negrão, Carlos Eduardo, Poli-De-Figueiredo, Carlos Eduardo, Polanczyk, Carisi Anne, Gonzaga, Carolina C., Amodeo, Celso, Rodrigues, Cibele Isaac Saad, Martins, Claudete, Kater, Claudio E., Giorgi, Dante Marcelo Artigas, Mion, Décio, Jr., Barbosa, Eduardo, Coelho, Eduardo Barbosa, Krieger, Eduardo Moacyr, Pimenta, Eduardo, Akamine, Eliana Hirome, de Freitas, Elizabete Viana, Lima, Emilton, Jr., Guerra, Enio Marcio Maia, Campana, Érika Maria Gonçalves, Consolim-Colombo, Fernanda M., de Almeida, Fernando Antonio, Nobre, Fernando, Fonseca, Flavia Lopes, de Oliveira Borelli, Flávio Antonio, Fuchs, Flávio Danni, Fonseca, Francisco Antonio Helfenstein, Carmo, Gabriel A.L., Lorenzi-Filho, Geraldo, Júnior, Gerson Alves Pereira, Gadonski, Giovani, Ceravolo, Graziela Scalianti, Salgado, Helio C., Lopes, Heno Ferreira, de Castro Chaves, Hilton, Junior, Antonello, Ivan Carlos Ferreira, de Sá Roriz Filho, Jarbas, Heimann, Joel C., Filho, José Augusto Soares Barreto, Krieger, José Eduardo, Tanus-Santos, José Eduardo, Martin, José Fernando Vilela, Ribeiro, José Márcio, de Carvalho, Júlia Batista, Ortega, Kátia Coelho, Moreira, Leila Beltrami, Florêncio, Leonardo Pereira, Paula, Letícia Germany, Magalhães, Lucelia Batista Neves Cunha, de Siqueira Veiga Jardim, Luciana Muniz Sanches, Drager, Luciano F., Bortolotto, Luiz Aparecido, Scala, Luiz César Nazário, de Gusmão Correia, Marcelo Lima, Torres, Márcia Regina Simas Gonçalves, Ribeiro, Márcio Carvalho, Mota-Gomes, Marco Antônio, Neres, Marcos S., Malachias, Marcus Vinícius Bolívar, Arruda, Maria Cecília Guimarães Marinho, Irigoyen, Maria Claudia, Izar, Maria Cristina, Magalhães, Maria Eliane Campos, de Carvalho, Maria Helena Catelli, Bombig, Maria Teresa Nogueira, Zanella, Maria Teresa, Rondon, Maria Urbana P. Brandão, de Toledo Durand, Marina, Neves, Mario Fritsch Toros, Strufaldi, Maristela Bassi, Drumond, Melina, Batlouni, Michel, Gus, Miguel, de Almeida Gouveia, Milena Motta, da Costa Lima, Nereida Kilza, Junior, Osvaldo Kohlmann, Pizzi, Oswaldo Luiz, Júnior, Oswaldo Passarelli, Coelho, Otávio Rizzi, Jardim, Paulo César Brandão Veiga, Lopes, Paulo César, Toscano, Paulo Roberto Pereira, de Miranda Cadaval, Ricardo Augusto, Lacchini, Riccardo, de Cássia Aleixo Tostes Passaglia, Rita, Gismondi, Ronaldo A.O.C., D'Avila, Ronaldo, Miranda, Roberto Dischinger, Pozzan, Roberto, Santos, Robson Augusto Souza dos, Fazan, Rubens, Jr., Póvoa, Rui Manuel dos Santos, Fuchs, Sandra Costa, Pinheiro, Sérgio Veloso Brant, de Souza Veiga Jardim, Thiago, Geleilete, Tufik José Magalhães, Souza, Weimar Kunz Sebba Barroso, Oigman, Wille, Junior, Wilson Nadruz, and Fortes, Zuleica Bruno

Published
2012
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22. Opportunities for Targeting the Angiotensin-Converting Enzyme 2/Angiotensin-(1-7)/Mas Receptor Pathway in Hypertension

Author

Fraga-Silva, Rodrigo Araujo, Ferreira, Anderson Jose, Santos, Souza Dos, and Augusto, Robson

Subjects
Mas receptor, Hypertension, Angiotensin converting enzyme 2, Renin-angiotensin system, Angiotensin-(1-7), hormones, hormone substitutes, and hormone antagonists, RAS
Abstract

It is well known that the renin-angiotensin system (RAS) plays a pivotal role in the pathophysiology of cardiovascular diseases. This is well illustrated by the great success of ACE inhibitors and angiotensin (Ang) II AT(1) blockers in the treatment of hypertension and its complications. In the past decade, the classical concept of RAS orchestrated by a series of enzymatic reactions culminating in the linear generation and action of Ang II has expanded and become more complex. From the discoveries of new components such as the angiotensin converting enzyme 2 and the receptor Mas emerged a novel concept of dual opposite branches of the RAS: one vasoconstrictor and pro-hypertensive composed of ACE/Ang II/AT1; and other vasodilator and anti-hypertensive composed of ACE2/Ang-(1-7)/Mas. In this review we will discuss recent findings concerning the biological role of the ACE2/Ang-(1-7)/Mas arm in the cardiovascular system and highlight the initiatives to develop potential therapeutic strategies based on this axis for treating hypertension.

23. Narrow-implant-retained overdenture in an atrophic mandibular ridge: a case report with 6-year follow-up.

Author

Araujo CR, Martins-Junior PA, Araujo RC, Sa MA, Wassall T, and Ferreira AJ

Subjects
Aged, Alveolar Bone Loss diagnostic imaging, Dental Implantation, Endosseous methods, Female, Humans, Mandible surgery, Radiography, Panoramic, Alveolar Bone Loss surgery, Dental Prosthesis, Implant-Supported methods, Denture, Overlay
Abstract

When atrophic jaws compromise oral rehabilitation with conventional implants, narrow-diameter implants can be used. This case report describes treatment of an edentulous 75-year-old diabetic woman with a severely resorbed mandibular ridge. Her mandibular dentition was restored with an overdenture supported by 3 narrow implants and 1 mini implant. Her maxillary dentition was restored with a conventional complete denture. A 6-year clinical and radiographic follow-up confirmed that the narrow implants had provided effective stability for the overdenture, providing improvements in phonetics and masticatory ability at a low cost.

Published
2015

24. Angiotensin converting enzyme 2 activator (DIZE) modulates metabolic profiles in mice, decreasing lipogenesis.

Author

de Macedo SM, Guimarares TA, Andrade JM, Guimaraes AL, Batista de Paula AM, Ferreira AJ, and Sousa Santos SH

Subjects
Adipose Tissue drug effects, Angiotensin-Converting Enzyme 2, Animals, Body Weight drug effects, Diminazene metabolism, Diminazene pharmacology, Enzyme Inhibitors pharmacology, Humans, Male, Mice, Proto-Oncogene Proteins p21(ras) metabolism, Diminazene analogs & derivatives, Enzyme Inhibitors metabolism, Lipogenesis drug effects, Peptidyl-Dipeptidase A metabolism, Transcriptome drug effects
Abstract

Recent studies have shown that angiotensin-converting enzyme 2 (ACE2)/angiotensin (Ang) -(1-7)/Mas axis activation is able to improve the metabolic profile, enhance glucose tolerance and insulin sensitivity, improve metabolic parameters, and counteract deleterious effects of Ang II. The effects of endogenous ACE 2 activation on the metabolic profile of mice are poorly studied. In this study, 12 weeks old male mice were treated with the ACE 2 activator (diminazene aceturate, DIZE, 1 mg/kg/day, gavage) or saline (control) for 30 days followed by glucose tolerance tests, insulin sensitivity tests, and blood analysis. Epididymal ACE2, ACE, angiotensinogen, acetyl-CoA carboxylase (ACC), and fatty acid synthase (FAS) were measured by quantitative RT-PCR. ACE 2 activation treatment lowered body weight (DIZE vs control) (28.69 vs 30.28g, P < 0.001), serum cholesterol (140,0 vs 177.5; P < .05), and serum triglycerides (75,00 vs 165,0; P < .05) as well as epididymal (0.008 vs 0.016; P < .05) and retroperitoneal (0.0024 vs. 0.0068; P < .01) adipose tissue weights. These effects were associated with significantly increased epididymal ACE 2 and decreased ACE and angiotensinogen (AGT) expression. Additionally, DIZE decreased adipogenesis-related gene transcription, such as ACC and FAS mRNA. In conclusion, these results indicate that activation of ACE2 by oral DIZE treatment improves the metabolic profile and reduces fat deposition in mice. These results, along with the reduction of lipogenesis markers open a new perspective for metabolic disorder pharmacotherapy.

Published
2015
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