293 results on '"Ferre R"'
Search Results
2. Ultrasound features of retroareolar breast carcinoma
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Ferre, R., Pare, M., and Mesurolle, B.
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- 2017
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3. Double-echo gradient chemical shift MR imaging fails to differentiate minimal fat renal angiomyolipomas from other homogeneous solid renal tumors
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Ferré, R., Cornelis, F., Verkarre, V., Eiss, D., Correas, J.M., Grenier, N., and Hélénon, O.
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- 2015
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4. Physical activity below the minimum international recommendations improves oxidative stress, ADMA levels, resting heart rate and small artery endothelial function
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Merino, J., Ferré, R., Girona, J., Aguas, D., Cabré, A., Plana, N., Vinuesa, A., Ibarretxe, D., Basora, J., Buixadera, C., and Masana, L.
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- 2015
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5. Lung ultrasound for the early diagnosis of COVID-19 pneumonia: an international multicenter study
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Volpicelli, G., Gargani, L., Perlini, S., Spinelli, S., Barbieri, G., Lanotte, A., Casasola, G. G., Nogue-Bou, R., Lamorte, A., Agricola, E., Villen, T., Deol, P. S., Nazerian, P., Corradi, F., Stefanone, V., Fraga, D. N., Navalesi, P., Ferre, R., Boero, E., Martinelli, G., Cristoni, L., Perani, C., Vetrugno, L., Mcdermott, C., Miralles-Aguiar, F., Secco, G., Zattera, C., Salinaro, F., Grignaschi, A., Boccatonda, A., Giostra, F., Infante, M. N., Covella, M., Ingallina, G., Burkert, J., Frumento, P., Forfori, F., Ghiadoni, L., Fraccalini, T., Vendrame, A., Basile, V., Cipriano, A., Frassi, F., Santini, M., Falcone, M., Menichetti, F., Barcella, B., Delorenzo, M., Resta, F., Vezzoni, G., Bonzano, M., Briganti, D. F., Cappa, G., Zunino, I., Demitry, L., Vignaroli, D., Dipietro, L. S. S., Bazzini, M., Capozza, V., Gonzalez, M. M., Gibal, R. V., Ibarz, R. P., Alfaro, L. M., Alfaro, C. M., Alins, M. G., Brown, A., Dunlop, H., Ralli, M. L., Persona, P., Russel, F. M., Pang, P. S., Rovida, S., Deana, C., Franchini, D., Gargani, Luna, Volpicelli, G., Gargani, L., Perlini, S., Spinelli, S., Barbieri, G., Lanotte, A., Casasola, G. G., Nogue-Bou, R., Lamorte, A., Agricola, E., Villen, T., Deol, P. S., Nazerian, P., Corradi, F., Stefanone, V., Fraga, D. N., Navalesi, P., Ferre, R., Boero, E., Martinelli, G., Cristoni, L., Perani, C., Vetrugno, L., Mcdermott, C., Miralles-Aguiar, F., Secco, G., Zattera, C., Salinaro, F., Grignaschi, A., Boccatonda, A., Giostra, F., Infante, M. N., Covella, M., Ingallina, G., Burkert, J., Frumento, P., Forfori, F., Ghiadoni, L., Fraccalini, T., Vendrame, A., Basile, V., Cipriano, A., Frassi, F., Santini, M., Falcone, M., Menichetti, F., Barcella, B., Delorenzo, M., Resta, F., Vezzoni, G., Bonzano, M., Briganti, D. F., Cappa, G., Zunino, I., Demitry, L., Vignaroli, D., Dipietro, L. S. S., Bazzini, M., Capozza, V., Gonzalez, M. M., Gibal, R. V., Ibarz, R. P., Alfaro, L. M., Alfaro, C. M., Alins, M. G., Brown, A., Dunlop, H., Ralli, M. L., Persona, P., Russel, F. M., Pang, P. S., Rovida, S., Deana, C., and Franchini, D.
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Adult ,medicine.medical_specialty ,Multivariate analysis ,Letter ,Coronavirus disease 2019 (COVID-19) ,Original ,COVID-19 ,Interstitial pneumonia ,Lung ultrasound ,SARS-CoV-2 ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,0302 clinical medicine ,Anesthesiology ,Internal medicine ,medicine ,Humans ,Lung ,Aged ,Ultrasonography ,business.industry ,030208 emergency & critical care medicine ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,Pneumonia ,Early Diagnosis ,030228 respiratory system ,Respiratory failure ,Observational study ,business - Abstract
Purpose To analyze the application of a lung ultrasound (LUS)-based diagnostic approach to patients suspected of COVID-19, combining the LUS likelihood of COVID-19 pneumonia with patient’s symptoms and clinical history. Methods This is an international multicenter observational study in 20 US and European hospitals. Patients suspected of COVID-19 were tested with reverse transcription-polymerase chain reaction (RT-PCR) swab test and had an LUS examination. We identified three clinical phenotypes based on pre-existing chronic diseases (mixed phenotype), and on the presence (severe phenotype) or absence (mild phenotype) of signs and/or symptoms of respiratory failure at presentation. We defined the LUS likelihood of COVID-19 pneumonia according to four different patterns: high (HighLUS), intermediate (IntLUS), alternative (AltLUS), and low (LowLUS) probability. The combination of patterns and phenotypes with RT-PCR results was described and analyzed. Results We studied 1462 patients, classified in mild (n = 400), severe (n = 727), and mixed (n = 335) phenotypes. HighLUS and IntLUS showed an overall sensitivity of 90.2% (95% CI 88.23–91.97%) in identifying patients with positive RT-PCR, with higher values in the mixed (94.7%) and severe phenotype (97.1%), and even higher in those patients with objective respiratory failure (99.3%). The HighLUS showed a specificity of 88.8% (CI 85.55–91.65%) that was higher in the mild phenotype (94.4%; CI 90.0–97.0%). At multivariate analysis, the HighLUS was a strong independent predictor of RT-PCR positivity (odds ratio 4.2, confidence interval 2.6–6.7, p
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- 2021
6. 154 Gamification of Point-of-Care Ultrasound: Are Students Learning?
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Russell, F., primary, Herbert, A., additional, Lobo, D., additional, Ferre, R., additional, Kaine, J., additional, Pallansch, J., additional, Soriano, P., additional, and Adame, J.D., additional
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- 2022
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7. 197 Deep Learning-Based Scoring of Pulmonary Congestion for BLUSHED AHF Trial
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Goldsmith, A., primary, Duggan, N., additional, Jin, M., additional, Lucassen, R., additional, Fischetti, C., additional, Ferre, R., additional, Boyer, E., additional, Kapur, T., additional, Pang, P., additional, and Russell, F., additional
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- 2022
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8. Gut microbiota is associated with metabolic health in children with obesity
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Alcazar, M., primary, Escribano, J., additional, Ferré, N., additional, Closa-Monasterolo, R., additional, Selma-Royo, M., additional, Feliu, A., additional, Castillejo, G., additional, Luque, V., additional, Feliu-Rovira, A., additional, Muñoz-Hernando, J., additional, Gutiérrez-Marín, D., additional, Zaragoza-Jordana, M., additional, Gispert-Llauradó, M., additional, Rubio-Torrents, M.C., additional, Núñez-Roig, M., additional, Alcázar, M., additional, Sentís, S., additional, Esteve, M., additional, Monné-Gelonch, R., additional, Basora, J.M., additional, Flores, G., additional, Hsu, P., additional, Rey-Reñones, C., additional, Alegret, C., additional, Guillen, N., additional, Alegret-Basora, C., additional, Ferre, R., additional, Arasa, F., additional, Alejos, A.M., additional, Diéguez, M., additional, Serrano, M.A., additional, Mallafré, M., additional, González-Hidalgo, R., additional, Braviz, L., additional, Resa, A., additional, Palacios, M., additional, Sabaté, A., additional, Simón, L., additional, Losilla, A.C., additional, De La Torre, S., additional, Rosell, L., additional, Adell, N., additional, Pérez, C., additional, Tudela-Valls, C., additional, Caro-Garduño, R., additional, Salvadó, O., additional, Pedraza, A., additional, Conchillo, J., additional, Morillo, S., additional, Garcia, S., additional, Mur, E.M., additional, Paixà, S., additional, Tolós, S., additional, Martín, R., additional, Aguado, F.J., additional, Cabedo, J.L., additional, Quezada, L.G., additional, Domingo, M., additional, Ortega, M., additional, Garcia, R.M., additional, Romero, O., additional, Pérez, M., additional, Fernández, M., additional, Villalobos, M.E., additional, Ricomà, G., additional, Capell, E., additional, Bosch, M., additional, Donado, A., additional, Sanchis, F.J., additional, Boix, A., additional, Goñi, X., additional, Castilla, E., additional, Pinedo, M.M., additional, Supersaxco, L., additional, Ferré, M., additional, Contreras, J., additional, Sanz-Manrique, N., additional, Lara, A., additional, Rodríguez, M., additional, Pineda, T., additional, Segura, S., additional, Vidal, S., additional, Salvat, M., additional, Mimbrero, G., additional, Albareda, A., additional, Guardia, J., additional, Gil, S., additional, Lopez, M., additional, Ruiz-Escusol, S., additional, Gallardo, S., additional, Machado, P., additional, Bocanegra, R., additional, Espejo, T., additional, Vendrell, M., additional, Solé, C., additional, Urbano, R., additional, Vázquez, M.T., additional, Fernández-Antuña, L., additional, Barrio, M., additional, Baudoin, A., additional, González, N., additional, Olivé, R., additional, Lara, R.M., additional, Dinu, C., additional, Vidal, C., additional, González, S., additional, Ruiz-Morcillo, E., additional, Ainsa, M.E., additional, Vilalta, P., additional, Aranda, B., additional, Boada, A., additional, and Balcells, E., additional
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- 2022
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9. Stress gradient effect on the crack nucleation process of a Ti–6Al–4V titanium alloy under fretting loading: Comparison between non-local fatigue approaches
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Ferré, R., Fouvry, S., Berthel, B., and Ruiz-Sabariego, J.-A.
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- 2013
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10. Computed-aided diagnosis (CAD) in the detection of breast cancer
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Dromain, C., Boyer, B., Ferré, R., Canale, S., Delaloge, S., and Balleyguier, C.
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- 2013
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11. Prediction of the Fretting Fatigue Crack Nucleation Endurance of a Ti-6V-4Al/Ti- 6V-4Al Interface: Influence of Plasticity and Tensile/Shear Fatigue Properties
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Ferre, R., Fouvry, S., Berthel, B., Amargier, R., and Ruiz-Sabariego, J.A.
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- 2013
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12. Surface Functionalization of AISI 316 Steel by Laser Texturing of Shaped Microcavities with Picosecond Pulses
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Sampedro, J., Ferre, R., Fernández, E., Pérez, I., Cárcel, B., Molina, T., and Ramos, J.A.
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- 2012
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13. Magnetization Processes in Mesoscopic Systems: Nucleation, Magnetization Reversal and Hysteresis
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Ferre, R., Bar’yakthar, Victor G., editor, Wigen, Philip E., editor, and Lesnik, Natalia A., editor
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- 1998
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14. Position, Navigation, and Timing (PNT) Through Low Earth Orbit (LEO) Satellites: A Survey on Current Status, Challenges, and Opportunities
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Prol, F. S., primary, Ferre, R. Morales, additional, Saleem, Z., additional, Valisuo, P., additional, Pinell, C., additional, Lohan, E. S., additional, Elsanhoury, M., additional, Elmusrati, M., additional, Islam, S., additional, Celikbilek, K., additional, Selvan, K., additional, Yliaho, J., additional, Rutledge, K., additional, Ojala, A., additional, Ferranti, L., additional, Praks, J., additional, Bhuiyan, M. Z. H., additional, Kaasalainen, S., additional, and Kuusniemi, H., additional
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- 2022
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15. The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group
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El Bairi, K., Haynes, H. R., Blackley, E., Fineberg, S., Shear, J., Turner, S., de Freitas, J. R., Sur, D., Amendola, L. C., Gharib, M., Kallala, A., Arun, I., Azmoudeh-Ardalan, F., Fujimoto, L., Sua, L. F., Liu, S. -W., Lien, H. -C., Kirtani, P., Balancin, M., El Attar, H., Guleria, P., Yang, W., Shash, E., Chen, I. -C., Bautista, V., Do Prado Moura, J. F., Rapoport, B. L., Castaneda, C., Spengler, E., Acosta-Haab, G., Frahm, I., Sanchez, J., Castillo, M., Bouchmaa, N., Md Zin, R. R., Shui, R., Onyuma, T., Husain, Z., Willard-Gallo, K., Coosemans, A., Perez, E. A., Provenzano, E., Ericsson, P. G., Richardet, E., Mehrotra, R., Sarancone, S., Ehinger, A., Rimm, D. L., Bartlett, J. M. S., Viale, G., Denkert, C., Hida, A. I., Sotiriou, C., Loibl, S., Hewitt, S. M., Badve, S., Symmans, W. F., Kim, R. S., Pruneri, G., Goel, S., Francis, P. A., Inurrigarro, G., Yamaguchi, R., Garcia-Rivello, H., Horlings, H., Afqir, S., Salgado, R., Adams, S., Kok, M., Dieci, M. V., Michiels, S., Demaria, S., Loi, S., Schelfhout, V., Arbzadeh, E., Bondanar, A., Reyes, S. A. G., Ruz, J. R., Kang, J., Xiang, L., Zimovjanova, M., Togores, P., Ozturk, T., Patil, A., Corpa, M., Whitehouse, A., Tan, B., de Paula, A., Rossetti, C., Lang-Schwarz, C., Mahon, S., Giacometti, C., Linderholm, B., Deman, F., Montagna, G., Gong, G., Pavcovich, M., Chaer, Y., Cabrero, I. A., de Brito, M. L., Ilieva, N., Fulop, A., Souza, M., Bilancia, D., Idowu, M., Johri, R., Szpor, J., Bachani, L., Schmitt, F., Giannotti, M., Kurebayashi, Y., Ramirez, B. E. A., Salido, E., Bortesi, L., Bonetto, S., Elomina, K., Lopez, P., Sharma, V., Edirisinghe, A., Mathur, D., Sahay, A., Mouloud, M. A., Giang, C. H., Mukolwe, E., Kiruka, E., Samberg, N., Abe, N., Brown, M., Millar, E., X. B., Li, Yuan, Z., Pasupathy, A., Miele, R., Luff, R., e Porfirio, M. M. A., Ajemba, O., Soni, R., Orvieto, E., Dimaio, M., Thomas, J., Merard, R., Subramaniam, M. M., Apolinario, T., Preda, O., Preda, R., Makanga, A., Maior, M. S., Li, L., Saghatchian, M., Saurine, T., Janssen, E., Cochran, J., Vlada, N., Cappellesso, R., Elfer, K., Hollick, M., Desai, S., Oner, G., Schreurs, A., Liu, S., Perera, R., Mercurio, P., Garcia, F., Hosny, K., Matsumoto, H., van Deurzen, C., Bianchini, G., Coban, I., Jahangir, A., Rahman, A., Stover, D., Luz, P., Martel, A., Waumans, Y., Stenzinger, A., Cortes, J., Dimitrova, P., Nauwelaers, I., Velasco, M., Fan, F., Akturk, G., Firer, M., Roxanis, I., Schneck, M., Wen, H., Cockenpot, V., Konstantinov, A., Calatrava, A., Vidya, M. N., Choi, H. J., Jank, P., Ciinen, A. H., Sabanathan, D., Floris, G., Hoeflmayer, D., Hamada, T., Laudus, N., Grigoriadis, A., Porcellato, I., Acs, B., Miglietta, F., Parrodi, J., Clunie, D., Calhoun, B., F. -I., Lu, Lefevre, A., Tabbarah, S., Tran, W., Garcia-murillas, I., Jelinic, P., Boeckx, C., Souza, S., Cebollero, M. C., Felip, E., Rendon, J. L. S., El Gabry, E., Saltz, J., Bria, E., Garufi, G., Hartman, J., Sebastian, M., Olofsson, H., Kooreman, L., Cucherousset, J., Mathieu, M. -C., Ballesteros-Merino, C., Siziopikou, P., Fong, J., Klein, M., Qulis, I. R. I., Wesseling, J., Bellolio, E., Araya, J. C., Naber, S., Cheang, M., Castellano, I., Ales, A., Laenkholm, A. -V., Kulka, J., Quinn, C., Sapino, A., Amendoeira, I., Marchio, C., Braybrooke, J., Vincent-Salomon, A., Korski, K. P., Sofopoulos, M., Stovgaard, E. I. S., Bianchi, S., Bago-Horvath, Z., Yu, C., Regitnig, P., Hall, S., Kos, Z., Sant, S., Tille, J. -C., Gallas, B., Bethmann, D., Savas, P., Mendes, L., Soler, T., van Seijen, M., Gruosso, T., Quintana, A., Giltnane, J., Van den Eynden, G., Duregon, E., de Cabo, R., Recamo, P. C., Gaboury, L., Zimmerman, J., Pop, C. S., Wernicke, A., Williams, D., Gill, A., Solomon, B., Thapa, B., Farshid, G., Gilham, L., Christie, M., O'Toole, S., Hendry, S., Fox, S. B., Luen, S. J., Lakhani, S. R., Fuchs, T., John, T., Brcic, I., Hainfellner, J., Sigurd, L., Preusser, M., Poortmans, P., Decaluwe, A., Carey, C., Colpaert, C., Larsimont, D., Peeters, D., Broeckx, G., van de Vijver, K., Buisseret, L., Dirix, L., Hertoghs, M., Piccart, M., Ignatiadis, M., Van Bockstal, M., Sirtaine, N., Vermeulen, P., de Wind, R., Declercq, S., Gevaert, T., Haibe-Kans, B., Nelson, B. H., Watson, P. H., Leung, S., Nielsen, T., Shi, L., Balslev, E., Thagaard, J., Almangush, A., Makitie, A., Joensuu, H., Lundin, J., Drubay, D., Roblin, E., Andre, F., Penault-Llorca, F., Lemonnier, J., Adam, J., Lacroix-Triki, M., Ternes, N., Radosevic-Robin, N., Klaushen, F., Weber, K., Harbeck, N., Gluz, O., Wienert, S., Cserni, G., Vingiani, A., Criscitiello, C., Solinas, C., Curigliano, G., Konishi, E., Suzuki, E., Yoshikawa, K., Kawaguchi, K., Takada, M., Toi, M., Ishida, M., Shibata, N., Saji, S., Kogawa, T., Sakatani, T., Okamoto, T., Moriya, T., Kataoka, T., Shimoi, T., Sugie, T., Mukohara, T., Shu, Y., Kikawa, Y., Kozuka, Y., Sayed, S., Rahayu, R., Ramsaroop, R., Senkus-Konefka, E., Chmielik, E., Cardoso, F., Ribeiro, J., Chan, J., Dent, R., Martin, M., Hagen, C., Guerrero, A., Rojo, F., Comerma, L., Nuciforo, P., Serrano, V. V., Camaea, V. P., Steenbruggen, T., Ciompi, F., Nederlof, I., Jan, Hudecek, van der Laak, J., van den Berg, J., Voorwerk, L., van de Vijver, M., de Maaker, M., Linn, S., Mckenzie, H., Somaiah, N., Tutt, A., Swanton, C., Hiley, C., Moore, D. A., Hall, J. A., Le Quesne, J., Jabbar, K. A., al Bakir, M., Hills, R., Irshad, S., Yuan, Y., Li, Z., Liu, M., Klein, J., Fadare, O., Thompson, A., Lazar, A. J., Gown, A., Lo, A., Garrido Castro, A. C., Madabhushi, A., Moreira, A., Richardson, A., Beck, A. H., Bellizzi, A. M., Wolff, A., Harbhajanka, A., Sharma, A., Cimino-Mathews, A., Srinivasan, A., Singh, B., Chennubhotla, C. S., Chauhan, C., Dillon, D. A., Zardavas, D., Johnson, D. B., Thompson, A. E., Brogi, E., Reisenbichler, E., Huang, E., Hirsch, F. R., Mcarthur, H., Ziai, J., Brock, J., Kerner, J., Zha, J., Lennerz, J. K., Carter, J. M., Reis-Filho, J., Sparano, J., Balko, J. M., Pogue-Geile, K., Steele, K. E., Blenman, K. R. M., Allison, K. H., Pusztai, L., Cooper, L., Estrada, V. M., Flowers, M., Robson, M., Rebelatto, M. C., Hanna, M. G., Goetz, M. P., Khojasteh, M., Sanders, M. E., Regan, M. M., Misialek, M., Amgad, M., Tung, N., Singh, R., Huang, R., Pierce, R. H., Leon-Ferre, R., Swain, S., Ely, S., Kim, S. -R., Bedri, S., Paik, S., Schnitt, S., D'Alfons, T., Kurkure, U., Bossuyt, V., Tong, W., Wang, Y., Dos Anjos, C. H., Gaire, F., Van Diest, P. J., El Bairi, Khalid [0000-0002-8414-4145], de Freitas, Juliana Ribeiro [0000-0003-4978-7273], Sur, Daniel [0000-0002-0926-4614], Amendola, Luis Claudio [0000-0002-6404-450X], Azmoudeh-Ardalan, Farid [0000-0003-4701-0532], Kirtani, Pawan [0000-0002-2343-7016], Yang, Wenxian [0000-0002-5349-9680], Castillo, Miluska [0000-0002-0111-3176], Provenzano, Elena [0000-0003-3345-3965], Mehrotra, Ravi [0000-0001-9453-1408], Ehinger, Anna [0000-0001-9225-7396], Rimm, David L [0000-0001-5820-4397], Bartlett, John MS [0000-0002-0347-3888], Denkert, Carsten [0000-0002-2249-0982], Hida, Akira I [0000-0002-4486-8819], Sotiriou, Christos [0000-0002-5745-9977], Hewitt, Stephen M [0000-0001-8283-1788], Badve, Sunil [0000-0001-8861-9980], Symmans, William Fraser [0000-0002-1526-184X], Goel, Shom [0000-0001-8329-9084], Francis, Prudence A [0000-0002-7207-9286], Horlings, Hugo [0000-0003-4782-8828], Salgado, Roberto [0000-0002-1110-3801], Demaria, Sandra [0000-0003-4426-0499], Loi, Sherene [0000-0001-6137-9171], Apollo - University of Cambridge Repository, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'anatomie pathologique, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), and UNICANCER
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Oncology ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,TRASTUZUMAB ,Improved survival ,MICROENVIRONMENT ,Review Article ,SUBTYPES ,NEOADJUVANT CHEMOTHERAPY ,0302 clinical medicine ,Breast cancer ,Ecology,Evolution & Ethology ,PROGNOSTIC-SIGNIFICANCE ,Medicine and Health Sciences ,Pharmacology (medical) ,TUMOR-INFILTRATING LYMPHOCYTES ,Stage (cooking) ,RC254-282 ,Chemical Biology & High Throughput ,0303 health sciences ,Human Biology & Physiology ,Genome Integrity & Repair ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,ASSOCIATION ,3. Good health ,030220 oncology & carcinogenesis ,Biomarker (medicine) ,Life Sciences & Biomedicine ,Genetics & Genomics ,medicine.medical_specialty ,chemical and pharmacologic phenomena ,International Immuno-Oncology Biomarker Working Group ,Predictive markers ,03 medical and health sciences ,Signalling & Oncogenes ,SDG 3 - Good Health and Well-being ,Internal medicine ,692/53/2423 ,medicine ,Radiology, Nuclear Medicine and imaging ,In patient ,030304 developmental biology ,Computational & Systems Biology ,Science & Technology ,IDENTIFICATION ,business.industry ,review-article ,Cancer ,03.01. Általános orvostudomány ,Immunotherapy ,Tumour Biology ,medicine.disease ,PREDICTIVE-VALUE ,692/4028/67/1347 ,Programmed death 1 ,business ,FREE SURVIVAL - Abstract
The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed death-ligand 1 (PD-L1). These patients may potentially benefit from ICI targeting the programmed death 1 (PD-1)/PD-L1 signaling axis. The use of tumor-infiltrating lymphocytes (TILs) as predictive and prognostic biomarkers has been under intense examination. Emerging data suggest that TILs are associated with response to both cytotoxic treatments and immunotherapy, particularly for patients with triple-negative BC. In this review from The International Immuno-Oncology Biomarker Working Group, we discuss (a) the biological understanding of TILs, (b) their analytical and clinical validity and efforts toward the clinical utility in BC, and (c) the current status of PD-L1 and TIL testing across different continents, including experiences from low-to-middle-income countries, incorporating also the view of a patient advocate. This information will help set the stage for future approaches to optimize the understanding and clinical utilization of TIL analysis in patients with BC. ispartof: NPJ BREAST CANCER vol:7 issue:1 ispartof: location:United States status: published
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- 2021
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16. 258P Analysis of patients (pts) without an initial triple-negative breast cancer (TNBC) diagnosis (Dx) in the phase III ASCENT study of sacituzumab govitecan (SG) in brain metastases-negative (BMNeg) metastatic TNBC (mTNBC)
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O'Shaughnessy, J., primary, Brufsky, A., additional, Rugo, H.S., additional, Tolaney, S.M., additional, Diab, S., additional, Punie, K., additional, Sardesai, S., additional, Hamilton, E., additional, Loirat, D., additional, Traina, T.A., additional, Leon-Ferre, R., additional, Hurvitz, S.A., additional, Kalinsky, K., additional, Bardia, A., additional, Henry, S., additional, Mayer, I., additional, Hong, Q., additional, Phan, S., additional, and Cortés, J., additional
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- 2021
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17. Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer
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Kos, Z., Roblin, E., Kim, R. S., Michiels, S., Gallas, B. D., Chen, W., van de Vijver, K. K., Goel, S., Adams, S., Demaria, S., Viale, G., Nielsen, T. O., Badve, S. S., Symmans, W. F., Sotiriou, C., Rimm, D. L., Hewitt, S., Denkert, C., Loibl, S., Luen, S. J., Bartlett, J. M. S., Savas, P., Pruneri, G., Dillon, D. A., Cheang, M. C. U., Tutt, A., Hall, J. A., Kok, M., Horlings, H. M., Madabhushi, A., van der Laak, J., Ciompi, F., Laenkholm, A. -V., Bellolio, E., Gruosso, T., Fox, S. B., Araya, J. C., Floris, G., Hudecek, J., Voorwerk, L., Beck, A. H., Kerner, J., Larsimont, D., Declercq, S., Van den Eynden, G., Pusztai, L., Ehinger, A., Yang, W., Abduljabbar, K., Yuan, Y., Singh, R., Hiley, C., Bakir, M., Lazar, A. J., Naber, S., Wienert, S., Castillo, M., Curigliano, G., Dieci, M. -V., Andre, F., Swanton, C., Reis-Filho, J., Sparano, J., Balslev, E., Chen, I. -C., Stovgaard, E. I. S., Pogue-Geile, K., Blenman, K. R. M., Penault-Llorca, F., Schnitt, S., Lakhani, S. R., Vincent-Salomon, A., Rojo, F., Braybrooke, J. P., Hanna, M. G., Soler-Monso, M. T., Bethmann, D., Castaneda, C. A., Willard-Gallo, K., Sharma, A., Lien, H. -C., Fineberg, S., Thagaard, J., Comerma, L., Gonzalez-Ericsson, P., Brogi, E., Loi, S., Saltz, J., Klaushen, F., Cooper, L., Amgad, M., Moore, D. A., Salgado, R., Hyytiainen, A., Hida, A. I., Thompson, A., Lefevre, A., Gown, A., Lo, A., Sapino, A., Moreira, A. M., Richardson, A., Vingiani, A., Bellizzi, A. M., Guerrero, A., Grigoriadis, A., Garrido-Castro, A. C., Cimino-Mathews, A., Srinivasan, A., Acs, B., Singh, B., Calhoun, B., Haibe-Kans, B., Solomon, B., Thapa, B., Nelson, B. H., Ballesteroes-Merino, C., Criscitiello, C., Boeckx, C., Colpaert, C., Quinn, C., Chennubhotla, C. S., Solinas, C., Drubay, D., Sabanathan, D., Peeters, D., Zardavas, D., Hoflmayer, D., Johnson, D. B., Thompson, E. A., Perez, E., Elgabry, E. A., Blackley, E. F., Reisenbichler, E., Chmielik, E., Gaire, F., F. -I., Lu, Azmoudeh-Ardalan, F., Peale, F., Hirsch, F. R., Acosta-Haab, G., Farshid, G., Broeckx, G., Koeppen, H., Haynes, H. R., Mcarthur, H., Joensuu, H., Olofsson, H., Cree, I., Nederlof, I., Frahm, I., Brcic, I., Chan, J., Ziai, J., Brock, J., Weseling, J., Giltnane, J., Lemonnier, J., Zha, J., Ribeiro, J., Lennerz, J. K., Carter, J. M., Hartman, J., Hainfellner, J., Le Quesne, J., Juco, J. W., van den Berg, J., Sanchez, J., Cucherousset, J., Adam, J., Balko, J. M., Saeger, K., Siziopikou, K., Sikorska, K., Weber, K., Steele, K. E., Emancipator, K., El Bairi, K., Allison, K. H., Korski, K., Buisseret, L., Shi, L., Kooreman, L. F. S., Molinero, L., Estrada, M. V., Van Seijen, M., Lacroix-Triki, M., Sebastian, M. M., Balancin, M. L., Mathieu, M. -C., van de Vijver, M., Rebelatto, M. C., Piccart, M., Goetz, M. P., Preusser, M., Khojasteh, M., Sanders, M. E., Regan, M. M., Barnes, M., Christie, M., Misialek, M., Ignatiadis, M., de Maaker, M., Van Bockstal, M., Harbeck, N., Tung, N., Laudus, N., Sirtaine, N., Burchardi, N., Ternes, N., Radosevic-Robin, N., Gluz, O., Grimm, O., Nuciforo, P., Jank, P., Kirtani, P., Watson, P. H., Jelinic, P., Francis, P. A., Russell, P. A., Pierce, R. H., Hills, R., Leon-Ferre, R., de Wind, R., Shui, R., Leung, S., Tabbarah, S., Souza, S. C., O'Toole, S., Swain, S., Dudgeon, S., Willis, S., Ely, S., Bedri, S., Irshad, S., Liu, S., Hendry, S., Bianchi, S., Braganca, S., Paik, S., Luz, S., Gevaert, T., D'Alfons, T., John, T., Sugie, T., Kurkure, U., Bossuyt, V., Manem, V., Camaea, V. P., Tong, W., Tran, W. T., Wang, Y., Allory, Y., Husain, Z., Bago-Horvath, Z., Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Institut Gustave Roussy (IGR), Division of Pathology and Laboratory Medicine, Università degli Studi di Milano [Milano] (UNIMI)-European Institute of Oncology [Milan] (ESMO), Institut Jules Bordet [Bruxelles], Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Charité, Institute of Pathology, Translational Tumorpathology Unit, German Breast Group, University of the Sunshine Coast (USC), European Institute of Oncology [Milan] (ESMO), Breakthrough Breast Cancer Centre, London Institute of Cancer, Department of Pathology, The Netherlands Cancer Institute, Division of Experimental Therapy, The Netherlands Cancer Institute NKI/AvL, Odense University Hospital, Unité de génétique et biologie des cancers (U830), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Breast Medical Oncology [Houston], The University of Texas M.D. Anderson Cancer Center [Houston], Helsingborg Hospital, Division of Experimental Therapeutics [Milan, Italy], Département de médecine oncologique [Gustave Roussy], Cancer Research UK Lung Cancer Centre of Excellence [Londres, Royaume-Uni], University College of London [London] (UCL), Memorial Sloane Kettering Cancer Center [New York], Herlev and Gentofte Hospital, Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Southern Queensland (USQ), Pharmacogenomics Unit [Paris], Department of Genetics [Paris], Institut Curie [Paris]-Institut Curie [Paris], Instituto de Física Teórica UAM/CSIC (IFT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Ctr Biomol Struct & Org, University of Maryland [College Park], University of Maryland System-University of Maryland System, The University of Sydney, Breast Cancer Translational Research Laboratory, Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB)-Faculté de Médecine [Bruxelles] (ULB), Innovation North - Faculty of Information and Technology, Leeds Metropolitan University, Int Immuno-Oncology Biomarker, Graduate School, CCA - Cancer biology and immunology, Pathology, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Oncostat (U1018 (Équipe 2)), Institut Gustave Roussy (IGR)-Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Università degli Studi di Milano = University of Milan (UNIMI)-European Institute of Oncology [Milan] (ESMO), German Breast Group (GBG), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Gallas, Brandon D [0000-0001-7332-1620], van de Vijver, Koen K [0000-0002-2026-9790], Demaria, Sandra [0000-0003-4426-0499], Badve, Sunil S [0000-0001-8861-9980], Symmans, W Fraser [0000-0002-1526-184X], Rimm, David L [0000-0001-5820-4397], Savas, Peter [0000-0001-5999-428X], Hall, Jacqueline A [0000-0003-0708-1360], Horlings, Hugo M [0000-0003-4782-8828], van der Laak, Jeroen [0000-0001-7982-0754], Bellolio, Enrique [0000-0003-0079-5264], Araya, Juan Carlos [0000-0003-3501-8203], Floris, Giuseppe [0000-0003-2391-5425], Hudeček, Jan [0000-0003-1071-5686], Ehinger, Anna [0000-0001-9225-7396], Lazar, Alexander J [0000-0002-6395-4499], Castillo, Miluska [0000-0002-0111-3176], Curigliano, Giuseppe [0000-0003-1781-2518], Sparano, Joseph [0000-0002-9031-2010], Braybrooke, Jeremy P [0000-0003-1943-7360], Hanna, Matthew G [0000-0002-7536-1746], Willard-Gallo, Karen [0000-0002-1150-1295], Sharma, Ashish [0000-0002-1011-6504], Comerma, Laura [0000-0002-0249-4636], Gonzalez-Ericsson, Paula [0000-0002-6292-6963], Loi, Sherene [0000-0001-6137-9171], Cooper, Lee [0000-0002-3504-4965], Apollo - University of Cambridge Repository, Research Programs Unit, Heikki Joensuu / Principal Investigator, HUS Comprehensive Cancer Center, Department of Oncology, Medicum, Gallas, Brandon D. [0000-0001-7332-1620], van de Vijver, Koen K. [0000-0002-2026-9790], Badve, Sunil S. [0000-0001-8861-9980], Symmans, W. Fraser [0000-0002-1526-184X], Rimm, David L. [0000-0001-5820-4397], Hall, Jacqueline A. [0000-0003-0708-1360], Horlings, Hugo M. [0000-0003-4782-8828], Lazar, Alexander J. [0000-0002-6395-4499], Braybrooke, Jeremy P. [0000-0003-1943-7360], and Hanna, Matthew G. [0000-0002-7536-1746]
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Oncology ,[SDV]Life Sciences [q-bio] ,THERAPY ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,Prognostic markers ,0302 clinical medicine ,Breast cancer ,Medicine and Health Sciences ,Pharmacology (medical) ,Lymphocytes ,Stromal tumor ,health care economics and organizations ,0303 health sciences ,CHEMOTHERAPY ,Sciences bio-médicales et agricoles ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,3. Good health ,Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] ,PROGNOSTIC VALUE ,Clinical Practice ,030220 oncology & carcinogenesis ,Educational resources ,Immunosurveillance ,medicine.medical_specialty ,3122 Cancers ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,IMMUNITY ,lcsh:RC254-282 ,Article ,Limfòcits ,Càncer de mama ,03 medical and health sciences ,Gastrointestinal cancer ,SDG 3 - Good Health and Well-being ,Internal medicine ,692/53/2422 ,medicine ,Radiology, Nuclear Medicine and imaging ,Càncer gastrointestinal ,030304 developmental biology ,Predictive biomarker ,Tumor-infiltrating lymphocytes ,business.industry ,Médecine pathologie humaine ,medicine.disease ,Cancérologie ,Human medicine ,business ,SYSTEM ,631/67/580/1884 - Abstract
Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines have been widely embraced by the clinical and research communities. We evaluated sources of variability in sTIL assessment by pathologists in three previous sTIL ring studies. We identify common challenges and evaluate impact of discrepancies on outcome estimates in early TNBC using a newly-developed prognostic tool. Discordant sTIL assessment is driven by heterogeneity in lymphocyte distribution. Additional factors include: technical slide-related issues; scoring outside the tumor boundary; tumors with minimal assessable stroma; including lymphocytes associated with other structures; and including other inflammatory cells. Small variations in sTIL assessment modestly alter risk estimation in early TNBC but have the potential to affect treatment selection if cutpoints are employed. Scoring and averaging multiple areas, as well as use of reference images, improve consistency of sTIL evaluation. Moreover, to assist in avoiding the pitfalls identified in this analysis, we developed an educational resource available at www.tilsinbreastcancer.org/pitfalls., info:eu-repo/semantics/published
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- 2020
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18. Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials
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Hudecek, J., Voorwerk, L., van Seijen, M., Nederlof, I., de Maaker, M., van den Berg, J., van de Vijver, K. K., Sikorska, K., Adams, S., Demaria, S., Viale, G., Nielsen, T. O., Badve, S. S., Michiels, S., Symmans, W. F., Sotiriou, C., Rimm, D. L., Hewitt, S. M., Denkert, C., Loibl, S., Loi, S., Bartlett, J. M. S., Pruneri, G., Dillon, D. A., Cheang, M. C. U., Tutt, A., Hall, J. A., Kos, Z., Salgado, R., Kok, M., Horlings, H. M., Hyytiainen, A., Hida, A. I., Thompson, A., Lefevre, A., Lazar, A. J., Gown, A., Lo, A., Sapino, A., Madabhushi, A., Moreira, A., Richardson, A., Vingiani, A., Beck, A. H., Bellizzi, A. M., Guerrero, A., Grigoriadis, A., Ehinger, A., Garrido-Castro, A., Vincent-Salomon, A., Laenkholm, A. -V., Sharma, A., Cimino-Mathews, A., Srinivasan, A., Acs, B., Singh, B., Calhoun, B., Haibe-Kans, B., Solomon, B., Thapa, B., Nelson, B. H., Gallas, B. D., Castaneda, C., Ballesteros-Merino, C., Criscitiello, C., Boeckx, C., Colpaert, C., Quinn, C., Chennubhotla, C. S., Swanton, C., Solinas, C., Hiley, C., Drubay, D., Bethmann, D., Moore, D. A., Larsimont, D., Sabanathan, D., Peeters, D., Zardavas, D., Hoflmayer, D., Johnson, D. B., Thompson, E. A., Brogi, E., Perez, E., Elgabry, E. A., Stovgaard, E. S., Blackley, E. F., Roblin, E., Reisenbichler, E., Bellolio, E., Balslev, E., Chmielik, E., Gaire, F., Andre, F., F. -I., Lu, Azmoudeh-Ardalan, F., Rojo, F., Gruosso, T., Ciompi, F., Peale, F., Hirsch, F. R., Klauschen, F., Penault-Llorca, F., Acosta Haab, G., Farshid, G., van den Eynden, G., Curigliano, G., Floris, G., Broeckx, G., Gonzalez-Ericsson, Koeppen, H., Haynes, H. R., Mcarthur, H., Joensuu, H., Olofsson, H., Lien, H. -C., Chen, I. -C., Cree, I., Frahm, I., Brcic, I., Chan, J., Ziai, J., Brock, J., Wesseling, J., Giltnane, J., Kerner, J. K., Thagaard, J., Braybrooke, J. P., van der Laak, J. A. W. M., Lemonnier, J., Zha, J., Ribeiro, J., Lennerz, J. K., Carter, J. M., Saltz, J., Hartman, J., Hainfellner, J., Quesne, J. L., Juco, J. W., Reis-Filho, J., Sanchez, J., Sparano, J., Cucherousset, J., Araya, J. C., Adam, J., Balko, J. M., Saeger, K., Siziopikou, K., Willard-Gallo, K., Weber, K., Pogue-Geile, K. L., Steele, K. E., Emancipator, K., Abduljabbar, K., El Bairi, K., Blenman, K. R. M., Allison, K. H., Korski, K., Pusztai, L., Comerma, L., Buisseret, L., Cooper, L. A. D., Shi, L., Kooreman, L. F. S., Molinero, L., Estrada, M. V., Lacroix-Triki, M., Al Bakir, M., Sebastian, M. M., van de Vijver, M., Balancin, M. L., Dieci, M. V., Mathieu, M. -C., Rebelatto, M. C., Piccart, M., Hanna, M. G., Goetz, M. P., Preusser, M., Khojasteh, M., Sanders, M. E., Regan, M. M., Barnes, M., Christie, M., Misialek, M., Ignatiadis, M., van Bockstal, M., Castillo, M., Amgad, M., Harbeck, N., Tung, N., Laudus, N., Sirtaine, N., Burchardi, N., Ternes, N., Radosevic-Robin, N., Gluz, O., Grimm, O., Nuciforo, P., Jank, P., Gonzalez-Ericsson, P., Kirtani, P., Jelinic, P., Watson, P. H., Savas, P., Francis, P. A., Russell, P. A., Singh, R., Kim, R. S., Pierce, R. H., Hills, R., Leon-Ferre, R., de Wind, R., Shui, R., De Clercq, S., Leung, S., Tabbarah, S., Souza, S. C., O'Toole, S., Swain, S., Dudgeon, S., Willis, S., Ely, S., Kim, S. -R., Bedri, S., Irshad, S., Liu, S. -W., Goel, S., Hendry, S., Bianchi, S., Braganca, S., Paik, S., Wienert, S., Fox, S. B., Luen, S. J., Naber, S., Schnitt, S. J., Sua, L. F., Lakhani, S. R., Fineberg, S., Soler, T., Gevaert, T., D'Alfonso, T., John, T., Sugie, T., Kurkure, U., Bossuyt, V., Manem, V., Camara, V. P., Tong, W., Chen, W., Yang, W., Tran, W. T., Wang, Y., Yuan, Y., Allory, Y., Husain, Z., Bago-Horvath, Z., Division of Pathology and Laboratory Medicine, Università degli Studi di Milano [Milano] (UNIMI)-European Institute of Oncology [Milan] (ESMO), Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Institut Gustave Roussy (IGR), Institut Jules Bordet [Bruxelles], Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Charité, Institute of Pathology, Translational Tumorpathology Unit, German Breast Group, Breast Cancer Translational Research Laboratory, Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB)-Faculté de Médecine [Bruxelles] (ULB), University of the Sunshine Coast (USC), European Institute of Oncology [Milan] (ESMO), Breakthrough Breast Cancer Centre, London Institute of Cancer, Department of Pathology, The Netherlands Cancer Institute, Division of Experimental Therapy, The Netherlands Cancer Institute NKI/AvL, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Hudeček, Jan [0000-0003-1071-5686], van de Vijver, Koen K [0000-0002-2026-9790], Demaria, Sandra [0000-0003-4426-0499], Badve, Sunil S [0000-0001-8861-9980], Symmans, William Fraser [0000-0002-1526-184X], Rimm, David L [0000-0001-5820-4397], Loi, Sherene [0000-0001-6137-9171], Hall, Jacqueline A [0000-0003-0708-1360], Horlings, Hugo M [0000-0003-4782-8828], Apollo - University of Cambridge Repository, van de Vijver, Koen K. [0000-0002-2026-9790], Badve, Sunil S. [0000-0001-8861-9980], Rimm, David L. [0000-0001-5820-4397], Hall, Jacqueline A. [0000-0003-0708-1360], Horlings, Hugo M. [0000-0003-4782-8828], Università degli Studi di Milano = University of Milan (UNIMI)-European Institute of Oncology [Milan] (ESMO), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Oncostat (U1018 (Équipe 2)), Institut Gustave Roussy (IGR)-Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, German Breast Group (GBG), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])
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0301 basic medicine ,Oncology ,medicine.medical_specialty ,[SDV]Life Sciences [q-bio] ,medicine.medical_treatment ,MEDLINE ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Review Article ,lcsh:RC254-282 ,631/67/1857 ,Tumour biomarkers ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,692/53 ,Internal medicine ,Medicine and Health Sciences ,medicine ,Pharmacology (medical) ,Radiology, Nuclear Medicine and imaging ,692/4028/67/580 ,Stromal tumor ,Biomarkers ,Tumour immunology ,business.industry ,Risk management framework ,review-article ,Médecine pathologie humaine ,631/67/1347 ,Immunotherapy ,Sciences bio-médicales et agricoles ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] ,3. Good health ,Review article ,Clinical trial ,Cancérologie ,030104 developmental biology ,030220 oncology & carcinogenesis ,Biomarker (medicine) ,business - Abstract
Stromal tumor-infiltrating lymphocytes (sTILs) are a potential predictive biomarker for immunotherapy response in metastatic triple-negative breast cancer (TNBC). To incorporate sTILs into clinical trials and diagnostics, reliable assessment is essential. In this review, we propose a new concept, namely the implementation of a risk-management framework that enables the use of sTILs as a stratification factor in clinical trials. We present the design of a biomarker risk-mitigation workflow that can be applied to any biomarker incorporation in clinical trials. We demonstrate the implementation of this concept using sTILs as an integral biomarker in a single-center phase II immunotherapy trial for metastatic TNBC (TONIC trial, NCT02499367), using this workflow to mitigate risks of suboptimal inclusion of sTILs in this specific trial. In this review, we demonstrate that a web-based scoring platform can mitigate potential risk factors when including sTILs in clinical trials, and we argue that this framework can be applied for any future biomarker-driven clinical trial setting., info:eu-repo/semantics/published
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- 2020
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19. The path to a better biomarker: application of a risk management framework for the implementation of PD-L1 and TILs as immuno-oncology biomarkers in breast cancer clinical trials and daily practice
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Gonzalez-Ericsson, P, Stovgaard, ES, Sua, LF, Reisenbichler, E, Kos, Z, Carter, JM, Michiels, S, Le Quesne, J, Nielsen, TO, Laenkholm, A-V, Fox, SB, Adam, J, Bartlett, JMS, Rimm, DL, Quinn, C, Peeters, D, Dieci, M, Vincent-Salomon, A, Cree, I, Hida, A, Balko, JM, Haynes, HR, Frahm, I, Acosta-Haab, G, Balancin, M, Bellolio, E, Yang, W, Kirtani, P, Sugie, T, Ehinger, A, Castaneda, CA, Kok, M, McArthur, H, Siziopikou, K, Badve, S, Fineberg, S, Gown, A, Viale, G, Schnitt, SJ, Pruneri, G, Penault-Llorca, F, Hewitt, S, Thompson, EA, Allison, KH, Symmans, WF, Bellizzi, AM, Brogi, E, Moore, DA, Larsimont, D, Dillon, DA, Lazar, A, Lien, H, Goetz, MP, Broeckx, G, El Bairi, K, Harbeck, N, Cimino-Mathews, A, Sotiriou, C, Adams, S, Liu, S-W, Loibl, S, Chen, I-C, Lakhani, SR, Juco, JW, Denkert, C, Blackley, EF, Demaria, S, Leon-Ferre, R, Gluz, O, Zardavas, D, Emancipator, K, Ely, S, Loi, S, Salgado, R, Sanders, M, Gonzalez-Ericsson, P, Stovgaard, ES, Sua, LF, Reisenbichler, E, Kos, Z, Carter, JM, Michiels, S, Le Quesne, J, Nielsen, TO, Laenkholm, A-V, Fox, SB, Adam, J, Bartlett, JMS, Rimm, DL, Quinn, C, Peeters, D, Dieci, M, Vincent-Salomon, A, Cree, I, Hida, A, Balko, JM, Haynes, HR, Frahm, I, Acosta-Haab, G, Balancin, M, Bellolio, E, Yang, W, Kirtani, P, Sugie, T, Ehinger, A, Castaneda, CA, Kok, M, McArthur, H, Siziopikou, K, Badve, S, Fineberg, S, Gown, A, Viale, G, Schnitt, SJ, Pruneri, G, Penault-Llorca, F, Hewitt, S, Thompson, EA, Allison, KH, Symmans, WF, Bellizzi, AM, Brogi, E, Moore, DA, Larsimont, D, Dillon, DA, Lazar, A, Lien, H, Goetz, MP, Broeckx, G, El Bairi, K, Harbeck, N, Cimino-Mathews, A, Sotiriou, C, Adams, S, Liu, S-W, Loibl, S, Chen, I-C, Lakhani, SR, Juco, JW, Denkert, C, Blackley, EF, Demaria, S, Leon-Ferre, R, Gluz, O, Zardavas, D, Emancipator, K, Ely, S, Loi, S, Salgado, R, and Sanders, M
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- 2020
20. Crystalline silicon surface passivation by amorphous silicon carbide films
- Author
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Vetter, M., Martín, I., Ferre, R., Garín, M., and Alcubilla, R.
- Published
- 2007
- Full Text
- View/download PDF
21. Optical-geometrical effects on the photoluminescence spectra of Si nanocrystals embedded in SiO2
- Author
-
Ferre, R., Garrido, B., Pellegrino, P., Morante, J.R., Peralvarez, M., Carreras, J., and Garcia, C.
- Subjects
Photoluminescence -- Analysis ,Silicon crystals -- Optical properties ,Physics - Abstract
A demonstration that thickness, optical constants, and details of the multilayer stack, together with the detection setting, strongly influence the photoluminescence spectra of Si nanocrystals embedded in SiO2 is presented. Due to multiple reflections of the visible light against the opaque silicon substrate, an interference pattern is built inside the oxide layer, which is responsible for the modifications in the measured spectra.
- Published
- 2005
22. Electronic properties of intrinsic and doped amorphous silicon carbide films
- Author
-
Vetter, M., Voz, C., Ferre, R., Martín, I., Orpella, A., Puigdollers, J., Andreu, J., and Alcubilla, R.
- Published
- 2006
- Full Text
- View/download PDF
23. 190 Long-Term Survival of Ultrasound Guided Peripheral Intravenous Catheters
- Author
-
Harrison, N.J., primary, Gerhart, C., additional, Kimlinger, M., additional, Mercer, E., additional, Gray, C., additional, Boyd, J., additional, and Ferre, R., additional
- Published
- 2020
- Full Text
- View/download PDF
24. Ultrasound identification of landmarks preceding lumbar puncture: a pilot study
- Author
-
Ferre, R M, Sweeney, T W, and Strout, T D
- Published
- 2009
- Full Text
- View/download PDF
25. Phosphorus-diffused silicon solar cell emitters with plasma enhanced chemical vapor deposited silicon carbide
- Author
-
Orpella, A., Vetter, M., Ferré, R., Martín, I., Puigdollers, J., Voz, C., and Alcubilla, R.
- Published
- 2005
- Full Text
- View/download PDF
26. Antimicrobial peptides: membrane affinity as the basis for selectivity and high local concentrations as the basis for activity: YSF-81
- Author
-
Melo, M., Ferre, R., Correia, A. D., Feliu, L., Planas, M., Bardajm, E., and Castanho, M. A. R. B.
- Published
- 2008
27. Optical and electrical properties of Si-nanocrystals ion beam synthesized in SiO 2
- Author
-
Garrido, B., López, M., Pérez-Rodrı́guez, A., Garcı́a, C., Pellegrino, P., Ferré, R., Moreno, J.A., Morante, J.R., Bonafos, C., Carrada, M., Claverie, A., de la Torre, J., and Souifi, A.
- Published
- 2004
- Full Text
- View/download PDF
28. Tumor-infiltrating lymphocytes in triple-negative breast cancer.
- Author
-
Leon-Ferre, R. A.
- Subjects
BREAST cancer prognosis ,LYMPHOCYTE count ,LYMPHOCYTES ,CANCER patients - Abstract
The article highlights findings from several studies in breast cancer research: one examining the prognostic significance of tumour-infiltrating lymphocytes in early-stage triple-negative breast cancer, another investigating the potential anti-tumour activity of enobosarm in advanced breast cancer patients with specific receptor profiles.
- Published
- 2024
29. Abstract P3-08-09: The 21-gene recurrence score and chemotherapy use in triple negative breast cancer (TNBC) and HER2 positive breast cancer: A National Cancer Database study
- Author
-
Boughey, JC, primary, Hoskin, TL, additional, Cocco, D, additional, Day, CN, additional, Leon-Ferre, R, additional, Habermann, EB, additional, and Goetz, MP, additional
- Published
- 2019
- Full Text
- View/download PDF
30. Magnetization reversal in cobalt and nickel electrodeposited nanowires
- Author
-
Ounadjela, K., Ferre, R., Louail, L., George, J.M., Maurice, J.L., Piraux, L., and Dubois, S.
- Subjects
Thin films -- Magnetic properties ,Wire -- Analysis ,Magnetization -- Analysis ,Crystals -- Magnetic properties ,Domain structure -- Analysis ,Physics - Published
- 1997
31. Erratum to “Ultrasound features of retroareolar breast carcinoma” [Diagn. Interv. Imaging 98 (2017) 409–413]
- Author
-
Ferre, R., primary, Pare, M., additional, and Mesurolle, B., additional
- Published
- 2018
- Full Text
- View/download PDF
32. n-type emitter surface passivation in c-Si solar cells by means of antireflective amorphous silicon carbide layers.
- Author
-
Ferre, R., Martín, I., Ortega, P., Vetter, M., Torres, I., and Alcubilla, R.
- Subjects
- *
SILICON solar cells , *SILICON carbide , *AMORPHOUS substances , *PHOSPHORUS , *DIFFUSION - Abstract
Emitter saturation current densities (JOe) of phosphorus-diffused planar c-Si solar cell emitters passivated by silicon carbide (SiCx) layers have been determined in a wide sheet resistance range (20–500 Ω/sq). Phosphorus diffusions were performed using solid planar diffusion sources without employing any drive-in step. Stacks of two SiCx layers were deposited by plasma enhanced chemical vapor deposition: first a thin silicon rich layer with excellent passivating properties and then an antireflective carbon rich layer. The thickness of the passivating layer was optimized, reaching a trade-off between the better passivation achieved for thicker layers and the increased light absorption within the layer, which reduced the photocurrent. The surface recombination velocity and the optical losses were determined for each configuration and used to calculate photovoltaic conversion efficiency limits for 50 and 90 Ω/sq emitters. In both cases, optimum configuration is for the stacks with passivating layers that are about 8 nm thick. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
33. Optical-geometrical effects on the photoluminescence spectra of Si nanocrystals embedded in SiO2.
- Author
-
Ferre, R., Garrido, B., Pellegrino, P., Perálvarez, M., García, C., Moreno, J. A., Carreras, J., and Morante, J. R.
- Subjects
- *
NANOCRYSTALS , *CRYSTALS , *PHOTOLUMINESCENCE , *SPECTRUM analysis , *SILICON oxide , *OPTICAL constants - Abstract
We demonstrate that thickness, optical constants, and details of the multilayer stack, together with the detection setting, strongly influence the photoluminescence spectra of Si nanocrystals embedded in SiO2. Due to multiple reflections of the visible light against the opaque silicon substrate, an interference pattern is built inside the oxide layer, which is responsible for the modifications in the measured spectra. This interference effect is complicated by the depth dependence of (i) the intensity of the excitation laser and (ii) the concentration of the emitting nanocrystals. These variations can give rise to apparent features in the recorded spectra, such as peak shifts, satellite shoulders, and even splittings, which can be mistaken as intrinsic material features. Thus, they can give rise to an erroneous attribution of optical bands or estimate of the average particle size, while they are only optical-geometrical artifacts. We have analyzed these effects as a function of material composition (Si excess fraction) and thickness, and also evaluated how the geometry of the detection setup affects the measurements. To correct the experimental photoluminescence spectra and extract the true spectral shape of the emission from Si nanocrystals, we have developed an algorithm based on a modulation function, which depends on both the multilayer sequence and the experimental configuration. This procedure can be easily extended to other heterogeneous systems. [ABSTRACT FROM AUTHOR]
- Published
- 2005
- Full Text
- View/download PDF
34. Optical-geometrical effects on the photoluminescence spectra of Si nanocrystals embedded in SiO2.
- Author
-
Ferre, R., Garrido, B., Pellegrino, P., Perálvarez, M., García, C., Moreno, J. A., Carreras, J., and Morante, J. R.
- Subjects
NANOCRYSTALS ,CRYSTALS ,PHOTOLUMINESCENCE ,SPECTRUM analysis ,SILICON oxide ,OPTICAL constants - Abstract
We demonstrate that thickness, optical constants, and details of the multilayer stack, together with the detection setting, strongly influence the photoluminescence spectra of Si nanocrystals embedded in SiO
2 . Due to multiple reflections of the visible light against the opaque silicon substrate, an interference pattern is built inside the oxide layer, which is responsible for the modifications in the measured spectra. This interference effect is complicated by the depth dependence of (i) the intensity of the excitation laser and (ii) the concentration of the emitting nanocrystals. These variations can give rise to apparent features in the recorded spectra, such as peak shifts, satellite shoulders, and even splittings, which can be mistaken as intrinsic material features. Thus, they can give rise to an erroneous attribution of optical bands or estimate of the average particle size, while they are only optical-geometrical artifacts. We have analyzed these effects as a function of material composition (Si excess fraction) and thickness, and also evaluated how the geometry of the detection setup affects the measurements. To correct the experimental photoluminescence spectra and extract the true spectral shape of the emission from Si nanocrystals, we have developed an algorithm based on a modulation function, which depends on both the multilayer sequence and the experimental configuration. This procedure can be easily extended to other heterogeneous systems. [ABSTRACT FROM AUTHOR]- Published
- 2005
- Full Text
- View/download PDF
35. In Praise of Anthropomorphism
- Author
-
Ferré, Frederick and Ferré, R.
- Published
- 1984
36. n-type emitter surface passivation in c-Si solar cells by means of antireflective amorphous silicon carbide layers
- Author
-
Vetter, M., Ferre, R., Ortega, P., Alcubilla, R., and Martin, I.
- Subjects
Silicon carbide -- Electric properties ,Silicon carbide -- Optical properties ,Solar batteries -- Analysis ,Solar cells -- Analysis ,Physics - Abstract
A study determined emitter saturation current densities of phosphorus-diffused planar c-Si solar cell emitters passivated by silicon carbide (Si[C.sub.x]) layers in a wide sheet resistance range (20-500 [OMEGA]/sq). The surface recombination velocity and the optical losses are determined for each configuration and used to calculate photovoltaic conversion efficiency limits for 50 and 90 [OMEGA]/sq emitters.
- Published
- 2006
37. AB0307 Differential association of age and disease activity with carotid intima-media thickness in men and women with rheumatoid arthritis
- Author
-
Taverner, D, primary, Paredes, S, additional, Ferre, R, additional, Masana, L, additional, Castro, A, additional, and Vallve, JC, additional
- Published
- 2017
- Full Text
- View/download PDF
38. Crystal structure of EGFR kinase domain in complex with a sulfonyl fluoride probe XO44
- Author
-
Gajiwala, K.S., primary and Ferre, R., additional
- Published
- 2017
- Full Text
- View/download PDF
39. Surface states in template synthesized tin oxide nanoparticles
- Author
-
Cabot, A., Arbiol, J., Ferre, R., Morante, J.R., and Chen, Fanglin; Lu, Meilin
- Subjects
Spectrum analysis -- Analysis ,Silicon compounds -- Properties ,Silicon compounds -- Analysis ,Tin compounds -- Properties ,Tin compounds -- Analysis ,Physics - Abstract
Tin-oxide nanoparticles with controlled narrow size distributions are synthesized while physically encapsulated inside silica mesoporous templates. A redshift of the optical absorbency edge is observed by means of ultraviolet-visible spectroscopy.
- Published
- 2004
40. The Immunobiology of histologic transformation in follicular lymphoma: a multi‐omic case‐control study.
- Author
-
Soekojo, C. Y., Whitaker, K. R., Ferre, R. Leon, Maurer, M., and Villasboas, J. C.
- Subjects
FOLLICULAR lymphoma ,IMMUNOLOGY ,CASE-control method ,CYTOTOXIC T cells - Abstract
B Conclusions: b Our data suggests that immunological features such as soluble factors and peripheral blood immune cell profile, measured at the time of diagnosis of FL, may be associated with subsequent risk of HT. Efforts to date in understanding the pathobiology of HT in FL (HT-FL) have been focused on genomic factors leading to clonal evolution of lymphoma cells. B Introduction: b Histologic transformation (HT) is a singular event in the natural history of patients with follicular lymphoma (FL) which dramatically change the clinical course and portends a poor prognosis. [Extracted from the article]
- Published
- 2023
- Full Text
- View/download PDF
41. COORDINATED CHANGES IN THE TUMOR MICROENVIRONMENT (TME) ARE ASSOCIATED WITH INCREASED RISK OF THERAPEUTIC FAILURE IN NEWLY DIAGNOSED DIFFUSE LARGE B‐CELL LYMPHOMA (DLBCL).
- Author
-
Soekojo, C. Y., Whitaker, K. R., Ferre, R. Leon, Moore, R. M., Maurer, M. J., and Villasboas, J. C.
- Subjects
DIFFUSE large B-cell lymphomas ,THERAPEUTIC complications ,TUMOR microenvironment ,MACHINE learning - Abstract
A total of 3004 single cell events were acquired using MxIF, of which 55% were classified as B cells, 17% as T cells, 8% as macrophages, and 20% as other cells. B Introduction: b Despite advances, 20%-40% of patients with DLBCL do not achieve remission or relapse after an initial response. COORDINATED CHANGES IN THE TUMOR MICROENVIRONMENT (TME) ARE ASSOCIATED WITH INCREASED RISK OF THERAPEUTIC FAILURE IN NEWLY DIAGNOSED DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL). [Extracted from the article]
- Published
- 2023
- Full Text
- View/download PDF
42. Effects of the lercanidipine - Enalapril combination vs. The corresponding monotherapies on home blood pressure in hypertension: Evidence from a large database
- Author
-
Mancia, G, Omboni, S, Chazova, I, Coca, A, Girerd, X, Haller, H, Parati, G, Pauletto, P, Pupek Musialik, D, Svyshchenko, Y, Boye, A, Charrier, B, Couffin, Y, Marmor, P, Marty, J, Navarre, J, Ansari, A, Büttner, C, Kropp, M, Mehling, H, Paschen, C, Schenkenberger, I, Schneider, H, Sperling, K, Stübler, P, Von Behren, V, Lembo, G, Scanferla, F, Sechi, L, Gębala, A, Hoffmann, A, Janik, K, Klimza Masłowska, A, Kaczmarek, B, Koźminski, P, Makowiecka Cies̈la, M, Mordaka, R, Nowakowski, T, Pasternak, D, Skibińska, E, Sulik, P, Szpajer, M, Walczewska, J, Zaczek, M, Zienciuk Krajka, A, Alexeeva, N, Bokarev, I, Conrady, A, Emelyanov, A, Galustyan, A, Idrisova, E, Khasanov, N, Khokhlov, A, Libov, I, Reshetko, O, Sokurenko, G, Stryuk, R, Tereshchenko, S, Trofimov, V, Zrazhevsky, K, Carlos Calvo, S, De Teresa, L, Ferre, R, García, J, Gil, A, Gil, B, Montenegro, J, Oliván, J, Ortiz, J, Pascual, J, Rivera, A, De Quevedo, J, Zúñiga, M, Martinez, V, Pujol, M, Bazylevych, A, Gyrina, O, Ignatenko, G, Kazymyrko, V, Khomazyuk, T, Kononenko, L, Korzh, O, Kovalenko, V, Kuryata, O, Kushnir, M, Lishnevska, V, Lymar, I, Ostrovska, L, Popik, G, Rudyk, Y, Shershnyova, O, Sierkova, V, Storozhuk, B, Tseluyko, V, Vatutin, M, Vayda, M, Vizir, V, Volkov, V, Voloshyna, O, Yagensky, A, Zhurba, S, Zorin, V, MANCIA, GIUSEPPE, PARATI, GIANFRANCO, Zorin, V., Mancia, G, Omboni, S, Chazova, I, Coca, A, Girerd, X, Haller, H, Parati, G, Pauletto, P, Pupek Musialik, D, Svyshchenko, Y, Boye, A, Charrier, B, Couffin, Y, Marmor, P, Marty, J, Navarre, J, Ansari, A, Büttner, C, Kropp, M, Mehling, H, Paschen, C, Schenkenberger, I, Schneider, H, Sperling, K, Stübler, P, Von Behren, V, Lembo, G, Scanferla, F, Sechi, L, Gębala, A, Hoffmann, A, Janik, K, Klimza Masłowska, A, Kaczmarek, B, Koźminski, P, Makowiecka Cies̈la, M, Mordaka, R, Nowakowski, T, Pasternak, D, Skibińska, E, Sulik, P, Szpajer, M, Walczewska, J, Zaczek, M, Zienciuk Krajka, A, Alexeeva, N, Bokarev, I, Conrady, A, Emelyanov, A, Galustyan, A, Idrisova, E, Khasanov, N, Khokhlov, A, Libov, I, Reshetko, O, Sokurenko, G, Stryuk, R, Tereshchenko, S, Trofimov, V, Zrazhevsky, K, Carlos Calvo, S, De Teresa, L, Ferre, R, García, J, Gil, A, Gil, B, Montenegro, J, Oliván, J, Ortiz, J, Pascual, J, Rivera, A, De Quevedo, J, Zúñiga, M, Martinez, V, Pujol, M, Bazylevych, A, Gyrina, O, Ignatenko, G, Kazymyrko, V, Khomazyuk, T, Kononenko, L, Korzh, O, Kovalenko, V, Kuryata, O, Kushnir, M, Lishnevska, V, Lymar, I, Ostrovska, L, Popik, G, Rudyk, Y, Shershnyova, O, Sierkova, V, Storozhuk, B, Tseluyko, V, Vatutin, M, Vayda, M, Vizir, V, Volkov, V, Voloshyna, O, Yagensky, A, Zhurba, S, Zorin, V, MANCIA, GIUSEPPE, PARATI, GIANFRANCO, and Zorin, V.
- Abstract
Objective: To compare a combination of a dihydropyridine calcium-channel blocker with an angiotensin converting enzyme inhibitor vs. monotherapy with one or the other drug and placebo for their effects on home blood pressure (HBP). Methods: After a 2-week placebo wash-out, patients with an elevated office blood pressure (BP) (diastolic 100-109 and systolic <180 mmHg) and HBP (diastolic ≥85 mmHg) were randomized double-blind to a 10-week treatment with placebo, lercanidipine, 10 or 20 mg daily, enalapril, 10 or 20 mg daily, or the four possible combinations. In addition to office BP, HBP was self-measured via a validated semiautomatic device twice in the morning and twice in the evening during the 7 days before randomization and at the end of treatment. Baseline and treatment HBP values were separately averaged for each day, morning, evening or the whole monitoring period, excluding the first day. Day-by-day HBP variability was defined as the SD or the variation coefficient of the daily BP averages. Results: Eight hundred and fifty-four patients with valid HBP recordings at baseline and at the end of treatment were analyzed (intention-to-treat population). From the baseline value (147.0±11.6 mmHg) systolic/diastolic HBP showed a small reduction (average baseline-adjusted change: -1.8/-1.6 mmHg) with placebo, a more marked significant fall with monotherapies (-8.8/-5.9 mmHg, P < 0.001/<0.001 vs. placebo) and even more with combination treatment (11.6/-7.6 mmHg, P < 0.001/ < 0.001 vs. placebo and P < 0.01/ < 0.05 vs. monotherapy). A similar pattern was observed for each of the days of the BP self-monitoring period as well as for either morning or evening values, although the difference between mono and combination treatment appeared to be consistently significant for the morning values only. Day-by-day systolic BP-SD was unaffected by placebo and slightly reduced by drug treatments, with no, however, significant changes in SBP-variation coefficient. Baseline and end of
- Published
- 2016
43. Circulating Grp78/Bip Is Increased In Patients With Obesity And Related Metabolic Disorders And Is Associated With Atherosclerosis
- Author
-
Girona, J., Rodríguez-Borjabad, C., Ibarretxe, D., Vallvé, J.C., Ferré, R., Heras, M., Rodríguez-Calvo, R., Guaita-Esteruelas, S., Martínez-Micaelo, N., Plana, N., and Masana, L.
- Published
- 2019
- Full Text
- View/download PDF
44. Significant Impact Of A Lifestyle Educational Program On Children With Genetically Driven Hypercholesterolemia
- Author
-
Rodríguez-Borjabad, C., Ibarretxe, D., Feliu, A., Ferré, R., Rosell, L., Gil, M., Masana, L., and Plana, N.
- Published
- 2019
- Full Text
- View/download PDF
45. Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes
- Author
-
MATTHEWS, D. A., DRAGOVICH, P. S., WEBBER, S. E., FUHRMAN, S. A., PATICK, A. K., ZALMAN, L. S., HENDRICKSON, T. F., LOVE, R. A., PRINS, T. J., MARAKOVITS, J. T., ZHOU, R., TIKHE, J., FORD, C. E., MEADOR, J. W., FERRE, R. A., BROWN, E. L., BINFORD, S. L., BROTHERS, M. A., DELISLE, D. M., and WORLAND, S. T.
- Subjects
Rhinoviruses -- Research ,Proteases -- Research ,Viral vaccines -- Research ,Influenza vaccines -- Research ,Science and technology - Abstract
Human rhinoviruses, the most important etiologic agents of the common cold, are messenger-active single-stranded monocistronic RNA viruses that have evolved a highly complex cascade of proteolytic processing events to control viral gene expression and replication. Most maturation cleavages within the precursor polyprotein are mediated by rhinovirus 3C protease (or its immediate precursor, 3CD), a cysteine protease with a trypsin-like polypeptide fold. High-resolution crystal structures of the enzyme from three viral serotypes have been used for the design and elaboration of 3C protease inhibitors representing different structural and chemical classes. Inhibitors having [Alpha],[Beta]-unsaturated carbonyl groups combined with peptidyl-binding elements specific for 3C protease undergo a Michael reaction mediated by nucleophilic addition of the enzyme's catalytic Cys-147, resulting in covalent-bond formation and irreversible inactivation of the viral protease. Direct inhibition of 3C proteolytic activity in virally infected cells treated with these compounds can be inferred from dose-dependent accumulations of viral precursor polyproteins as determined by SDS/PAGE analysis of radiolabeled proteins. Cocrystal-structure-assisted optimization of 3C-protease-directed Michael acceptors has yielded molecules having extremely rapid in vitro inactivation of the viral protease, potent antiviral activity against multiple rhinovirus serotypes and low cellular toxicity. Recently, one compound in this series, AG7088, has entered clinical trials.
- Published
- 1999
46. Preference-Driven Refinement of Service Compositions
- Author
-
Ba, C., Costa, U., Halfeld-Ferrari, M., Ferre, R., Martin Musicante, Peralta, V., Robert, S., Laboratoire d'Informatique Fondamentale d'Orléans (LIFO), Ecole Nationale Supérieure d'Ingénieurs de Bourges-Université d'Orléans (UO), Université d'Orléans (UO)-Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Bases de données et traitement des langues naturelles (BDTLN), Laboratoire d'Informatique Fondamentale et Appliquée de Tours (LIFAT), Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), STIC-AMSUD 052/14, Université de Tours (UT)-Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université de Tours (UT)-Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), and Halfeld Ferrari, Mirian
- Subjects
[INFO.INFO-DB]Computer Science [cs]/Databases [cs.DB] ,[INFO.INFO-WB] Computer Science [cs]/Web ,ACM: H.: Information Systems ,[INFO.INFO-DS]Computer Science [cs]/Data Structures and Algorithms [cs.DS] ,[INFO.INFO-WB]Computer Science [cs]/Web ,[INFO.INFO-DB] Computer Science [cs]/Databases [cs.DB] ,[INFO.INFO-DS] Computer Science [cs]/Data Structures and Algorithms [cs.DS] - Abstract
POSTER presentation; International audience; The Service Oriented Computing Paradigm proposes the construction of applications by integrating pre-existent services. Since a large number of services may be available in the Cloud, the selection of services is a crucial task in the definition of a composition. The selected services should attend the requirements of the compound application, by considering both functional and non-functional requirements (including quality and preference constraints). As the number of available services increases, the automation of the selection task becomes desirable. We propose a method for the refinement of service compositions that takes the abstract specification of a composition, the definition of concrete services and user preferences. Our algorithm produces a list of refinements in preference order. Experiments show that our method can be used in practice.
- Published
- 2014
47. AB0241 Plasma Micro-RNAs Potentially Associated with The Increase Risk for Cardiovascular Disease in Rheumatoid Arthritis Patients
- Author
-
Paredes, S., primary, Taverner, D., additional, Vallve, J.C., additional, Ferre, R., additional, Castro, A., additional, and Masana, L., additional
- Published
- 2016
- Full Text
- View/download PDF
48. Effect of functional bread rich in potassium, g-aminobutyric acid and angiotensin-converting enzyme inhibitors on blood pressure, glucose metabolism and endothelial function a double-blind randomized crossover clinical trial
- Author
-
Universitat Rovira i Virgili, Becerra-Tomas N; Guasch-Ferre M; Quilez J; Merino J; Ferre R; Diaz-López A; Bulló M; Hernández-Alonso P; Palau-Galindo A; Salas-Salvadó J, Universitat Rovira i Virgili, and Becerra-Tomas N; Guasch-Ferre M; Quilez J; Merino J; Ferre R; Diaz-López A; Bulló M; Hernández-Alonso P; Palau-Galindo A; Salas-Salvadó J
- Abstract
© 2015 Wolters Kluwer Health, Inc. All rights reserved. Because it has been suggested that food rich in g-aminobutyric acid (GABA) or angiotensin-converting enzyme inhibitor (ACEI) peptides have beneficial effects on blood pressure (BP) and other cardiovascular risk factors, we tested the effects of low-sodium bread, but rich in potassium, GABA, and ACEI peptides on 24-hour BP, glucose metabolism, and endothelial function. A randomized, double-blind, crossover trial was conducted in 30 patients with pre or mild-to-moderate hypertension, comparing three 4-week nutritional interventions separated by 2-week washout periods. Patients were randomly assigned to consume 120 g/day of 1 of the 3 types of bread for each nutritional intervention: conventional wheat bread (CB), low-sodium wheat bread enriched in potassium (LSB), and low-sodium wheat bread rich in potassium, GABA, and ACEI peptides (LSBAfter LSB Compared with the consumption of CB or LSB, no greater beneficial effects on 24-hour BP, endothelial function, or glucose metabolism were demonstrated after the consumption of LSBG in a population with pre or mild-to-moderate hypertension. Further studies are warranted to clarify the effect of GABA on BP, preferably using a specific design for noninferiority trials and ambulatory BP monitoring as a measure of BP.
- Published
- 2015
49. Primary peritonitis due to Streptococcus A: Laparoscopic treatment
- Author
-
Legras, A., LoDico, R., Ferre, R., Valleur, P., and Pautrat, K.
- Published
- 2011
- Full Text
- View/download PDF
50. Péritonite primitive à streptocoque A : traitement cœlioscopique
- Author
-
Legras, A., LoDico, R., Ferre, R., Valleur, P., and Pautrat, K.
- Published
- 2011
- Full Text
- View/download PDF
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