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201 results on '"Ferrazzoli, Davide"'

14. Looking deeper: does a connection exist between fatigue and attentional deficits in Parkinson's disease? A conceptual framework

Author

Ortelli, Paola, primary, Versace, Viviana, additional, Saltuari, Leopold, additional, Randi, Anna, additional, Stolz, Jakob, additional, Dezi, Sabrina, additional, Maestri, Roberto, additional, Buechner, Susanne, additional, Giladi, Nir, additional, Oliviero, Antonio, additional, Sebastianelli, Luca, additional, and Ferrazzoli, Davide, additional

Published
2023
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16. Land Plus Aquatic Therapy Versus Land-Based Rehabilitation Alone for the Treatment of Freezing of Gait in Parkinson Disease: A Randomized Controlled Trial

Author

Clerici, llaria, Maestri, Roberto, Bonetti, Francesca, Ortelli, Paola, Volpe, Daniele, Ferrazzoli, Davide, and Frazzitta, Giuseppe

Subjects
Parkinson disease -- Care and treatment -- Analysis -- Patient outcomes -- Complications and side effects, Physical therapy -- Methods -- Comparative analysis, Gait disorders -- Causes of -- Patient outcomes, Hospital admission and discharge, Brain injuries, Clinical trials, Retirement benefits, Health
Abstract

Background. Freezing of gait (FOG) is one of the most disabling symptoms of Parkinson disease (PD). Different land-based rehabilitation approaches based on motor and cognitive strategies can be effective in treating FOG. Although there are data about the efficacy of aquatic therapy in ameliorating this phenomenon, no study has explored the combined effect of land-based therapies plus aquatic therapy in patients with PD who have FOG. Objective. The objective was to investigate the effectiveness of a multidisciplinary, intensive, motor-cognitive rehabilitation treatment (MIRT) in improving FOG and whether implementation with aquatic therapy (MIRT-AT) adds further benefits. Design. The design consisted of a single-blind, parallel-group, 1:1 allocation ratio, randomized trial. Setting. The Department of Parkinson Disease, Movement Disorders and Brain Injury Rehabilitation at 'Moriggia-Pelascini' Hospital (Gravedona ed Unid, Como, Italy) was used as the setting. Participants. Sixty hospitalized patients with PD who had FOG in Hoehn and Yahr stage 2 or 5-3 were included. Intervention. Sixty patients with PD + FOG were randomly assigned to 2 groups: 30 underwent a 4-week MIRT and 30 underwent a 4-week MIRT-AT. Measurements. The primary outcome measure was the Freezing of Gait Questionnaire; secondary- outcome measures were total Unified Parkinson Disease Rating Scale (UPDRS), UPDRS II, UPDRS III, Berg Balance Scale, Timed Up and Go Test, and 6-Minute Walk Test. These measures were assessed both at admission and discharge. Results. Participants in the 2 groups had similar age, sex distribution, Hoehn and Yahr stage, and most-affected side. At baseline, no difference in outcome measures was observed between the 2 groups. After treatment, a significant time effect was observed for all variables in both groups. No significant time x group interaction was observed. A betweengroup analysis showed nonsignificant differences between values at Tl and values at TO for all variables. Limitations. The limitations were the lack of a control group and follow-up. Conclusions. We showed that a multidisciplinary, intensive, and goal-based rehabilitation treatment, such as MIRT, improves FOG in patients with PD. Although aquatic therapy could be considered a useful approach for treating FOG, it does not add further benefits to this kind of motor-cognitive rehabilitation., I. Clerici, PT, Department of Parkinson's Disease, Movement Disorders and Brain Injury Rehabilitation, 'Moriggia-Pelascini' Hospital, Gravedona ed Uniti, Italy. R. Maestri, BME, Department of Biomedical Engineering, Istituti Clinici Scientifici Maugeri [...]

Published
2019
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20. Motivational and myopic mechanisms underlying dopamine medication-induced impulsive-compulsive behaviors in Parkinson's disease

Author

Dawson, Andrew, Ortelli, Paola, Carter, Adrian, Ferrazzoli, Davide, Dissanayaka, Nadeeka N., Evans, Andrew, Chye, Yann, Lorenzetti, Valentina, Frazzitta, Giuseppe, and Yücel, Murat

Subjects
Behavioral Neuroscience, Neuropsychology and Physiological Psychology, motivation, Cognitive Neuroscience, aggression, Parkinson’s disease, impulsivity, addiction, dopamine replacement therapy
Abstract

IntroductionDopaminergic medications can trigger impulsive-compulsive behaviors (ICBs) in pre-disposed patients with Parkinson's disease (PD), but what this implies on a neurocognitive level is unclear. Previous findings highlighted potentially exacerbated incentive motivation (willingness to work for rewards) and choice impulsivity (preferring smaller, immediate rewards over larger, delayed rewards) in PD patients with ICBs (PD + ICBs).MethodsTo deeply understand this evidence, we studied 24 PD + ICBs and 28 PD patients without ICBs (PD-ICBs). First of all, patients underwent the assessment of impulsivity traits, mood, anxiety, and addiction condition. We further administered robust objective and subjective measures of specific aspects of motivation. Finally, we explored whether these processes might link to any heightened antisocial behavior (aggression and risky driving) in PD + ICBs.ResultsHigh levels of positive urgency trait characterized PD + ICBs. They choose to exert more effort for rewards under the conditions of low and medium reward probability and as reward magnitude increases. Findings on choice impulsivity show a great tendency to delay discounting in PD + ICBs, other than a high correlation between delay and probability discounting. In addition, we found what appears to be the first evidence of heightened reactive aggression in PD patients with ICBs. Exacerbated incentive motivation and delay discounting trended toward positively predicting reactive aggression in PD + ICBs.DiscussionOur promising results suggest that there might be immense value in future large-scale studies adopting a transdiagnostic neurocognitive endophenotype approach to understanding and predicting the addictive and aggressive behaviors that can arise from dopaminergic medication in PD.

Published
2023

22. Altered motor cortex physiology and dysexecutive syndrome in patients with fatigue and cognitive difficulties after mild COVID‐19

Author

Ortelli, Paola, primary, Ferrazzoli, Davide, additional, Sebastianelli, Luca, additional, Maestri, Roberto, additional, Dezi, Sabrina, additional, Spampinato, Danny, additional, Saltuari, Leopold, additional, Alibardi, Alessia, additional, Engl, Michael, additional, Kofler, Markus, additional, Quartarone, Angelo, additional, Koch, Giacomo, additional, Oliviero, Antonio, additional, and Versace, Viviana, additional

Published
2022
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37. Stigma Experienced by Parkinson’s Disease Patients: A Descriptive Review of Qualitative Studies

Author

Maffoni, Marina, Giardini, Anna, Pierobon, Antonia, Ferrazzoli, Davide, and Frazzitta, Giuseppe

Subjects
Article Subject
Abstract

Parkinson’s disease (PD) is a neurodegenerative disease characterized by motor and nonmotor symptoms. Both of them imply a negative impact on Health-Related Quality of Life. A significant one is the stigma experienced by the parkinsonian patients and their caregivers. Moreover, stigma may affect everyday life and patient’s subjective and relational perception and it may lead to frustration and isolation. Aim of the present work is to qualitatively describe the stigma of PD patients stemming from literature review, in order to catch the subjective experience and the meaning of the stigma construct. Literature review was performed on PubMed database and Google Scholar (keywords: Parkinson Disease, qualitative, stigma, social problem, isolation, discrimination) and was restricted to qualitative data: 14 articles were identified to be suitable to the aim of the present overview. Results are divided into four core constructs: stigma arising from symptoms, stigma linked to relational and communication problems, social stigma arising from sharing perceptions, and caregiver’s stigma. The principal relations to these constructs are deeply analyzed and described subjectively through patients’ and caregiver’s point of view. The qualitative research may allow a better understanding of a subjective symptom such as stigma in parkinsonian patients from an intercultural and a social point of view.

Published
2017
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42. Land Plus Aquatic Therapy Versus Land-Based Rehabilitation Alone for the Treatment of Balance Dysfunction in Parkinson Disease: A Randomized Controlled Study With 6-Month Follow-Up

Author

Palamara, Grazia, primary, Gotti, Francesco, additional, Maestri, Roberto, additional, Bera, Rossana, additional, Gargantini, Roberto, additional, Bossio, Fabiola, additional, Zivi, Ilaria, additional, Volpe, Daniele, additional, Ferrazzoli, Davide, additional, and Frazzitta, Giuseppe, additional

Published
2017
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49. Intensive Rehabilitation Enhances Lymphocyte BDNF-TrkB Signaling in Patients With Parkinson’s Disease

Author

Fontanesi, Cecilia, primary, Kvint, Svetlana, additional, Frazzitta, Giuseppe, additional, Bera, Rossana, additional, Ferrazzoli, Davide, additional, Di Rocco, Alessandro, additional, Rebholz, Heike, additional, Friedman, Eitan, additional, Pezzoli, Gianni, additional, Quartarone, Angelo, additional, Wang, Hoau-Yan, additional, and Ghilardi, M. Felice, additional

Published
2015
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