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4. Minimally invasive versus open pancreatoduodenectomy for pancreatic and peri-ampullary neoplasm (DIPLOMA-2): study protocol for an international multicenter patient-blinded randomized controlled trial

Author

de Graaf, Nine, Emmen, Anouk M. L. H., Ramera, Marco, Björnsson, Bergthor, Boggi, Ugo, Bruna, Caro L., Busch, Olivier R., Daams, Freek, Ferrari, Giovanni, Festen, Sebastiaan, van Hilst, Jony, D’Hondt, Mathieu, Ielpo, Benedetto, Keck, Tobias, Khatkov, Igor E., Koerkamp, Bas Groot, Lips, Daan J., Luyer, Misha D. P., Mieog, J. Sven D., Morelli, Luca, Molenaar, I. Quintus, van Santvoort, Hjalmar C., Sprangers, Mirjam A. G., Ferrari, Clarissa, Berkhof, Johannes, Maisonneuve, Patrick, Abu Hilal, Mohammad, and Besselink, Marc G.

Published
2023
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6. AI-assisted capsule endoscopy reading in suspected small bowel bleeding: a multicentre prospective study

Author

Spada, Cristiano, Piccirelli, Stefania, Hassan, Cesare, Ferrari, Clarissa, Toth, Ervin, González-Suárez, Begoña, Keuchel, Martin, McAlindon, Marc, Finta, Ádám, Rosztóczy, András, Dray, Xavier, Salvi, Daniele, Riccioni, Maria Elena, Benamouzig, Robert, Chattree, Amit, Humphries, Adam, Saurin, Jean-Christophe, Despott, Edward J, Murino, Alberto, Johansson, Gabriele Wurm, Giordano, Antonio, Baltes, Peter, Sidhu, Reena, Szalai, Milan, Helle, Krisztina, Nemeth, Artur, Nowak, Tanja, Lin, Rong, and Costamagna, Guido

Published
2024
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7. The Brescia Internationally Validated European Guidelines on Minimally Invasive Pancreatic Surgery (EGUMIPS)

Author

Abu Hilal, Mohammad, van Ramshorst, Tess M.E., Boggi, Ugo, Dokmak, Safi, Edwin, Bjørn, Keck, Tobias, Khatkov, Igor, Ahmad, Jawad, Al Saati, Hani, Alseidi, Adnan, Azagra, Juan S., Björnsson, Bergthor, Can, Fatih M., D’Hondt, Mathieu, Efanov, Mikhail, Espin Alvarez, Francisco, Esposito, Alessandro, Ferrari, Giovanni, Groot Koerkamp, Bas, Gumbs, Andrew A., Hogg, Melissa E., Huscher, Cristiano G.S., Ielpo, Benedetto, Ivanecz, Arpad, Jang, Jin-Young, Liu, Rong, Luyer, Misha D.P., Menon, Krishna, Nakamura, Masafumi, Piardi, Tullio, Saint-Marc, Olivier, White, Steve, Yoon, Yoo-Seok, Zerbi, Alessandro, Bassi, Claudio, Berrevoet, Frederik, Chan, Carlos, Coimbra, Felipe J., Conlon, Kevin C.P., Cook, Andrew, Dervenis, Christos, Falconi, Massimo, Ferrari, Clarissa, Frigerio, Isabella, Fusai, Giuseppe K., De Oliveira, Michelle L., Pinna, Antonio D., Primrose, John N., Sauvanet, Alain, Serrablo, Alejandro, Smadi, Sameer, Badran, Ali, Baychorov, Magomet, Bannone, Elisa, van Bodegraven, Eduard A., Emmen, Anouk M.L.H., Giani, Alessandro, de Graaf, Nine, van Hilst, Jony, Jones, Leia R., Levi Sandri, Giovanni B., Pulvirenti, Alessandra, Ramera, Marco, Rashidian, Niki, Sahakyan, Mushegh A., Uijterwijk, Bas A., Zampedri, Pietro, Zwart, Maurice J.W., Alfieri, Sergio, Berti, Stefano, Butturini, Giovanni, Di Benedetto, Fabrizio, Ettorre, Giuseppe M., Giuliante, Felice, Jovine, Elio, Memeo, Riccardo, Portolani, Nazario, Ruzzenente, Andrea, Salvia, Roberto, Siriwardena, Ajith K., Besselink, Marc G., Asbun, Horacio J., Over, Paul, Saleh, Omar, and Rivizzigno, Piero

Published
2024
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9. Psychometric validation and cultural adaptation of the Italian medical student stressor questionnaire

Author

Dagani, Jessica, Buizza, Chiara, Ferrari, Clarissa, and Ghilardi, Alberto

Subjects
Medical students -- Psychological aspects, Medical colleges -- Social aspects, Stress (Psychology) -- Psychological aspects, Psychology and mental health
Abstract

Medical students encounter specific stressors that can lead to higher levels of psychological distress compared to their similar aged counterparts who study other subjects. The Medical Student Stressor Questionnaire (MSSQ) was developed to specifically identify stressors among medical students as well as measure the intensity of stress caused by the stressors. However, no Italian version has been validated to date. The aim of this study was to develop an Italian version of the MSSQ (MSSQ-I) and to assess its psychometric properties. The MSSQ has been translated and culturally validated into Italian. All medical students from the University of Brescia were asked to participate in a web-survey in which they were asked to complete the MSSQ-I. For the analysis of the stability over time, participating students were asked to complete again the MSSQ-I after about one month. Among 1754 medical students, 964 completed the MSSQ-I for the validation analyses. A first Confirmatory Factor Analysis and a subsequent Explanatory Factor Analysis outlined a slightly modified factor structure of the scale with five factors instead of six as in the original scale. The internal consistency on the overall scale was high ([alpha] = 0.94), as well as the internal consistency of each of the new factors: ([alpha] > 0.83 for the first four factors and [alpha] = 0.67 for the fifth). External validity analysis confirmed moderate/high concurrent validity. These results suggest that the MSSQ-I can be used as a tool to identify stressors among Italian medical students, although further research is needed to confirm its individual test-retest reliability., Author(s): Jessica Dagani [sup.1] , Chiara Buizza [sup.1] , Clarissa Ferrari [sup.2] , Alberto Ghilardi [sup.1] Author Affiliations: (1) grid.7637.5, 0000000417571846, Department of Clinical and Experimental Sciences, Section of Clinical [...]

Published
2022
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15. Virtual Reality-Based Psychoeducation for Dementia Caregivers: The Link between Caregivers' Characteristics and Their Sense of Presence.

Author

Morganti, Francesca, Gattuso, Maria, Singh Solorzano, Claudio, Bonomini, Cristina, Rosini, Sandra, Ferrari, Clarissa, Pievani, Michela, and Festari, Cristina

Subjects
CAREGIVERS, ALZHEIMER'S disease, BURDEN of care, STRUCTURAL equation modeling, CLINICAL neuropsychology
Abstract

In neuropsychology and clinical psychology, the efficacy of virtual reality (VR) experiences for knowledge acquisition and the potential for modifying conduct are well documented. Consequently, the scope of VR experiences for educational purposes has expanded in the health field in recent years. In this study, we sought to assess the effectiveness of ViveDe in a psychoeducational caregiver program. ViveDe is a VR application that presents users with possible daily life situations from the perspective of individuals with dementia. These situations can be experienced in immersive mode through 360° video. This research aimed to ascertain the associations between the sense of presence that can be achieved in VR and some users' psychological characteristics, such as distress and empathetic disposition. The study involved 36 informal caregivers of individuals with Alzheimer's disease. These participants were assessed using scales of anxiety and depression, perceived stress, empathy, and emotional regulation. They were asked to participate in a six-session psychoeducation program conducted online on dementia topics, in addition to experiencing the ViveDe application. The immersive VR sessions enabled the caregivers to directly experience the symptoms of dementia (e.g., spatial disorientation, agnosia, difficulty in problem-solving, and anomia) in everyday and social settings. The results indicated that although the experience in ViveDe (evaluated using the XRPS scale and five questions about emotional attunement) showed efficacy in producing a sense of first-person participation in the symptoms of dementia, further research is needed to confirm this. The structural equation model provided evidence that the characteristics of individuals who enjoy the VR experience play a determining role in the perceived sense of presence, which in turn affects the efficacy of the VR experience as a psychoeducational tool. Further research will be conducted to ascertain the potential role of these elements in conveying change in the caregivers of people with dementia. This will help us study the long-term effectiveness of a large-scale psychoeducation program in VR. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Virtual Reality Combined With Psychoeducation to Improve Emotional Well‐Being in Informal Caregivers of Alzheimer's Disease Patients: Rationale and Study Design of a Randomized Controlled Trial.

Author

Festari, Cristina, Bonomini, Cristina, Rosini, Sandra, Gattuso, Maria, Singh Solorzano, Claudio, Zanetti, Orazio, Corbo, Daniele, Agnelli, Giancarlo, Quattrini, Giulia, Ferrari, Clarissa, Gasparotti, Roberto, Pievani, Michela, and Morganti, Francesca

Subjects
ANXIETY prevention, EMPATHY, ALZHEIMER'S disease, HUMAN services programs, RESEARCH funding, STATISTICAL sampling, PSYCHOEDUCATION, TREATMENT effectiveness, RANDOMIZED controlled trials, MAGNETIC resonance imaging, VIRTUAL reality, BURDEN of care, PARADIGMS (Social sciences), CAREGIVERS, ONLINE education, COMBINED modality therapy, PSYCHOLOGICAL stress, ARTIFICIAL neural networks, PSYCHOLOGY of caregivers, DEMENTIA, WELL-being, VIDEO recording, COGNITION
Abstract

Objectives: Care for community‐dwelling people with dementia is frequently delegated to relatives, who find themselves in the role of informal caregivers with no practical management knowledge. This situation exposes caregivers to increased risk for emotional wellbeing. The current study aims to test whether the integration of the efficacy of an immersive virtual reality (VR) experience into an online psychoeducational program impacts caregiver empathy and therefore emotional wellbeing. Methods: One‐hundred informal caregivers of mild‐to‐moderate Alzheimer's disease (AD) patients will be enrolled and randomly assigned to (i) an online psychoeducational program (control arm); or (ii) an online psychoeducational program integrated with VR (experimental arm). VR will consist of 360‐degree videos involving the caregivers to an immersive experience of dementia symptoms from the patient's perspective. Before, after the intervention and after 2 months, all participants will complete validated clinical scales for caregiver burden and anxiety (primary outcomes) and sense of competence and dispositional empathy (secondary outcomes). A subsample of 50 participants will also undergo MRI exam, including structural and functional (resting‐state and task‐functional MRI [fMRI]) sequences. The fMRI task paradigm will use emotional stimuli to evaluate the neural correlate of empathy, by stressing its cognitive and affective components. The main outcome will be the change in the clinical assessment; the secondary outcome will be the change in brain connectivity of networks subserving the empathic and emotional functioning. Results: We expect that the psychoeducational program will decrease anxiety and stress, enabling caregivers to perceive themselves capable of managing AD patients at home, educating them on symptom handling and boosting their cognitive empathy. In the experimental intervention, the VR‐based experience will act as an add‐on to psychoeducation, leading to greater improvement in the assessed clinical dimensions. VR should, in fact, enable a deeper understanding of disease symptoms and improve caregivers' cognitive empathy. We expect that the experimental intervention will result in deeper comprehension of disease symptoms and further strengthen caregivers' cognitive empathy. At the neural level, we expect to observe increased activation in circuits subserving cognitive empathy and decreased activation in circuits underlying affective empathy. Conclusions: To the best of our knowledge, this will be the first randomized controlled trial assessing the effect of combining psychoeducational interventions with VR‐based experience in caregivers, and assessing both clinical and imaging outcomes. Trial Registration: Registered in ClinicalTrials.gov (NCT05780476) [ABSTRACT FROM AUTHOR]

Published
2024
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22. Changes in digestive cancer diagnosis during the SARS-CoV-2 pandemic in Italy: A nationwide survey

Author

Massironi, Sara, Bianco, Maria Antonia, Germanà, Bastianello, Rodinò, Stefano, Anderloni, Andrea, Mussetto, Alessandro, Nipote, Bruno, Russo, Salvatore, Manta, Raffaele, Lauri, Adriano, Occhipinti, Vincenzo, Marco, Marco Di, Giovannone, Maurizio, Binda, Cecilia, Sbrancia, Monica, Paolo, Maria Carla Di, de’-Angelis, Gian Luigi, Fiori, Giancarla, Dal-Fante, Marco, Caro, Giuseppe de, Usai-Satta, Paolo, Cesarini, Monica, Piras, Enrico, Stasi, Elisa, Serio, Giovanni, Montalbano, Luigi Maria, Mirante, Vincenzo Giorgio, Burattini, Osvaldo, Attardo, Simona, Bargiggia, Stefano, Dinca, Manuele, Missale, Guido, Alvisi, Costanza, Broglia, Francesco, Ferraris, Luca, Conti-Bellocchi, Maria Cristina, Luigiano, Carmelo, Pallio, Socrate, Brunacci, Matteo, Manfrini, Carlo, Bozzi, Rosamaria, Checchin, Davide, Togliani, Thomas, D'errico, Antonietta, Bazzoli, Franco, La Bianca, Orazio, Berretti, Debora, Alvaro, Domenico, Buscarini, Elisabetta, Benedetti, Antonio, Monica, Fabio, Pasquale, Luigi, Buttitta, Francesco, Cameletti, Michela, Ferrari, Clarissa, and Ricciardiello, Luigi

Published
2021
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23. Accuracy and reproducibility of automated white matter hyperintensities segmentation with lesion segmentation tool: A European multi-site 3T study

Author

Ribaldi, Federica, Altomare, Daniele, Jovicich, Jorge, Ferrari, Clarissa, Picco, Agnese, Pizzini, Francesca Benedetta, Soricelli, Andrea, Mega, Anna, Ferretti, Antonio, Drevelegas, Antonios, Bosch, Beatriz, Müller, Bernhard W., Marra, Camillo, Cavaliere, Carlo, Bartrés-Faz, David, Nobili, Flavio, Alessandrini, Franco, Barkhof, Frederik, Gros-Dagnac, Helene, Ranjeva, Jean-Philippe, Wiltfang, Jens, Kuijer, Joost, Sein, Julien, Hoffmann, Karl-Titus, Roccatagliata, Luca, Parnetti, Lucilla, Tsolaki, Magda, Constantinidis, Manos, Aiello, Marco, Salvatore, Marco, Montalti, Martina, Caulo, Massimo, Didic, Mira, Bargallo, Núria, Blin, Olivier, Rossini, Paolo M, Schonknecht, Peter, Floridi, Piero, Payoux, Pierre, Visser, Pieter Jelle, Bordet, Régis, Lopes, Renaud, Tarducci, Roberto, Bombois, Stephanie, Hensch, Tilman, Fiedler, Ute, Richardson, Jill C., Frisoni, Giovanni B., and Marizzoni, Moira

Published
2021
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25. CSF cutoffs for MCI due to AD depend on APOEε4 carrier status

Author

Marizzoni, Moira, Ferrari, Clarissa, Babiloni, Claudio, Albani, Diego, Barkhof, Frederik, Cavaliere, Libera, Didic, Mira, Forloni, Gianluigi, Fusco, Federica, Galluzzi, Samantha, Hensch, Tilman, Jovicich, Jorge, Marra, Camillo, Molinuevo, José Luis, Nobili, Flavio, Parnetti, Lucilla, Payoux, Pierre, Ranjeva, Jean-Philippe, Ribaldi, Federica, Rolandi, Elena, Rossini, Paolo Maria, Salvatore, Marco, Soricelli, Andrea, Tsolaki, Magda, Visser, Pieter Jelle, Wiltfang, Jens, Richardson, Jill C., Bordet, Régis, Blin, Olivier, and Frisoni, Giovanni B.

Published
2020
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28. Technology in the service of caregiver well‐being: an online psycho‐educational intervention combined with virtual reality

Author

Festari, Cristina, primary, Bonomini, Cristina, additional, Rosini, Sandra, additional, Gattuso, Maria, additional, Solorzano, Claudio Singh, additional, Zanetti, Orazio, additional, Corbo, Daniele, additional, Agnelli, Giancarlo, additional, Ferrari, Clarissa, additional, Gasparotti, Roberto, additional, Morganti, Francesca, additional, and Pievani, Michela, additional

Published
2023
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32. Randomized controlled trial on the efficacy of a multilevel non-pharmacologic intervention in older adults with subjective memory decline: design and baseline findings of the E.Mu.N.I. study

Author

Rolandi, Elena, Dodich, Alessandra, Galluzzi, Samantha, Ferrari, Clarissa, Mandelli, Sara, Ribaldi, Federica, Munaretto, Giulio, Ambrosi, Claudia, Gasparotti, Roberto, Violi, Davide, Canessa, Nicola, Iannaccone, Sandro, Marcone, Alessandra, Falini, Andrea, Hampel, Harald, Frisoni, Giovanni B., Cerami, Chiara, and Cavedo, Enrica

Published
2020
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33. Mild cognitive impairment with suspected nonamyloid pathology (SNAP)

Author

Caroli, Anna, Prestia, Annapaola, Galluzzi, Samantha, Ferrari, Clarissa, van der Flier, Wiesje M, Ossenkoppele, Rik, Van Berckel, Bart, Barkhof, Frederik, Teunissen, Charlotte, Wall, Anders E, Carter, Stephen F, Schöll, Michael, Choo, Il Han, Grimmer, Timo, Redolfi, Alberto, Nordberg, Agneta, Scheltens, Philip, Drzezga, Alexander, Frisoni, Giovanni B, Weiner, Michael, Aisen, Paul, Petersen, Ronald, Jack, Clifford R, Jagust, William, Trojanowki, JQ, Toga, Arthur W, Beckett, Laurel, Green, Robert C, Gamst, Anthony, Saykin, Andrew J, Morris, John, Potter, William Z, Montine, Tom, Thomas, Ronald G, Donohue, Michael, Walter, Sarah, Dale, Anders, Bernstein, Matthew, Felmlee, Joel, Fox, Nick, Thompson, Paul, Schuff, Norbert, Alexander, Gene, DeCarli, Charles, Bandy, Dan, Koeppe, Robert A, Foster, Norm, Reiman, Eric M, Chen, Kewei, Mathis, Chet, Cairns, Nigel J, Taylor-Reinwald, Lisa, Shaw, Les, Lee, Virginia M-Y, Korecka, Magdalena, Crawford, Karen, Neu, Scott, Harvey, Danielle, Kornak, John, Foroud, Tatiana M, Potkin, Steven, Shen, Li, Kachaturian, Zaven, Frank, Richard, Snyder, Peter J, Molchan, Susan, Kaye, Jeffrey, Dolen, Sara, Quinn, Joseph, Schneider, Lon, Pawluczyk, Sonia, Spann, Bryan M, Brewer, James, Vanderswag, Helen, Heidebrink, Judith L, Lord, Joanne L, Johnson, Kris, Doody, Rachelle S, Villanueva-Meyer, Javier, Chowdhury, Munir, Stern, Yaakov, Honig, Lawrence S, Bell, Karen L, Morris, John C, and Mintun, Mark A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Aging, Alzheimer's Disease, Neurosciences, Brain Disorders, Acquired Cognitive Impairment, Neurodegenerative, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Dementia, 2.1 Biological and endogenous factors, Aetiology, Neurological, Aged, Aged, 80 and over, Cognitive Dysfunction, Databases, Factual, Disease Progression, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neurodegenerative Diseases, Plaque, Amyloid, Predictive Value of Tests, Alzheimer's Disease Neuroimaging Initiative, Cognitive Sciences, Neurology & Neurosurgery, Clinical sciences
Abstract

ObjectivesThe aim of this study was to investigate predictors of progressive cognitive deterioration in patients with suspected non-Alzheimer disease pathology (SNAP) and mild cognitive impairment (MCI).MethodsWe measured markers of amyloid pathology (CSF β-amyloid 42) and neurodegeneration (hippocampal volume on MRI and cortical metabolism on [(18)F]-fluorodeoxyglucose-PET) in 201 patients with MCI clinically followed for up to 6 years to detect progressive cognitive deterioration. We categorized patients with MCI as A+/A- and N+/N- based on presence/absence of amyloid pathology and neurodegeneration. SNAPs were A-N+ cases.ResultsThe proportion of progressors was 11% (8/41), 34% (14/41), 56% (19/34), and 71% (60/85) in A-N-, A+N-, SNAP, and A+N+, respectively; the proportion of APOE ε4 carriers was 29%, 70%, 31%, and 71%, respectively, with the SNAP group featuring a significantly different proportion than both A+N- and A+N+ groups (p ≤ 0.005). Hypometabolism in SNAP patients was comparable to A+N+ patients (p = 0.154), while hippocampal atrophy was more severe in SNAP patients (p = 0.002). Compared with A-N-, SNAP and A+N+ patients had significant risk of progressive cognitive deterioration (hazard ratio = 2.7 and 3.8, p = 0.016 and p < 0.001), while A+N- patients did not (hazard ratio = 1.13, p = 0.771). In A+N- and A+N+ groups, none of the biomarkers predicted time to progression. In the SNAP group, lower time to progression was correlated with greater hypometabolism (r = 0.42, p = 0.073).ConclusionsOur findings support the notion that patients with SNAP MCI feature a specific risk progression profile.

Published
2015

34. The EADC‐ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity

Author

Frisoni, Giovanni B, Jack, Clifford R, Bocchetta, Martina, Bauer, Corinna, Frederiksen, Kristian S, Liu, Yawu, Preboske, Gregory, Swihart, Tim, Blair, Melanie, Cavedo, Enrica, Grothe, Michel J, Lanfredi, Mariangela, Martinez, Oliver, Nishikawa, Masami, Portegies, Marileen, Stoub, Travis, Ward, Chadwich, Apostolova, Liana G, Ganzola, Rossana, Wolf, Dominik, Barkhof, Frederik, Bartzokis, George, DeCarli, Charles, Csernansky, John G, deToledo‐Morrell, Leyla, Geerlings, Mirjam I, Kaye, Jeffrey, Killiany, Ronald J, Lehéricy, Stephane, Matsuda, Hiroshi, O'Brien, John, Silbert, Lisa C, Scheltens, Philip, Soininen, Hilkka, Teipel, Stefan, Waldemar, Gunhild, Fellgiebel, Andreas, Barnes, Josephine, Firbank, Michael, Gerritsen, Lotte, Henneman, Wouter, Malykhin, Nikolai, Pruessner, Jens C, Wang, Lei, Watson, Craig, Wolf, Henrike, deLeon, Mony, Pantel, Johannes, Ferrari, Clarissa, Bosco, Paolo, Pasqualetti, Patrizio, Duchesne, Simon, Duvernoy, Henri, Boccardi, Marina, Initiative, EADC‐ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging, Albert, Marilyn S, Bennet, David, Camicioli, Richard, Collins, D Louis, Dubois, Bruno, Hampel, Harald, denHeijer, Tom, Hock, Christofer, Jagust, William, Launer, Leonore, Maller, Jerome J, Mueller, Susan, Sachdev, Perminder, Simmons, Andy, Thompson, Paul M, Visser, Peter‐Jelle, Wahlund, Lars‐Olof, Weiner, Michael W, and Winblad, Bengt

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Brain Disorders, Biomedical Imaging, Clinical Research, Aged, Alzheimer Disease, Atrophy, Female, Functional Laterality, Hippocampus, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Internet, Magnetic Resonance Imaging, Male, Middle Aged, Neuroimaging, Organ Size, Reproducibility of Results, Hippocampal volumetry, Magnetic resonance, Alzheimer's disease, Biomarkers, Diagnostic criteria, Enrichment, Clinical trials, Validation, Harmonized protocol, Standard operating procedures, Manual segmentation, EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging Initiative, Geriatrics, Clinical sciences, Biological psychology
Abstract

BackgroundAn international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance.MethodsFourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T.ResultsThe agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P < .001), and physiological variability (49.2%, P < .001).ConclusionsThe HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms.

Published
2015

36. Temperament and character influence on depression treatment outcome

Author

Balestri, Martina, Porcelli, Stefano, Souery, Daniel, Kasper, Siegfried, Dikeos, Dimitris, Ferentinos, Panagiotis, Papadimitriou, George N., Rujescu, Dan, Martinotti, Giovanni, Di Nicola, Marco, Janiri, Luigi, Caletti, Elisabetta, Mandolini, Gian Mario, Pigoni, Alessandro, Paoli, Riccardo Augusto, Lazzaretti, Matteo, Brambilla, Paolo, Sala, Michela, Abbiati, Vera, Bellani, Marcella, Perlini, Cinzia, Rossetti, Maria Gloria, Piccin, Sara, Bonivento, Carolina, Fabbro, Dora, Damante, Giuseppe, Ferrari, Clarissa, Rossi, Roberta, Pedrini, Laura, Benedetti, Francesco, Montgomery, Stuart, Zohar, Joseph, Mendlewicz, Julien, and Serretti, Alessandro

Published
2019
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38. Investigating the role of childhood trauma in inflammatory gene expression differences observed in depression treatment response groups

Author

Worrell, Courtney, primary, Cattaneo, Annamaria, additional, Ferrari, Clarissa, additional, Mariani, Nicole, additional, Lombardo, Giulia, additional, Antonietta Nettis, Maria, additional, Nikkheslat, Naghmeh, additional, Sforzini, Luca, additional, Kose, Melisa, additional, Cattane, Nadia, additional, Pointon, Linda, additional, Cowen, Phillip J., additional, Cavanagh, Jonathan, additional, Harrison, Neil A., additional, Mondelli, Valeria, additional, Bullmore, Edward T., additional, and Pariante, Carmine M., additional

Published
2023
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39. COVID-19 Acute Respiratory Distress Syndrome: Treatment with Helmet CPAP in Respiratory Intermediate Care Unit by Pulmonologists in the Three Italian Pandemic Waves

Author

Piluso, Martina, primary, Ferrari, Clarissa, additional, Pagani, Silvia, additional, Usai, Pierfranco, additional, Raschi, Stefania, additional, Parachini, Luca, additional, Oggionni, Elisa, additional, Melacini, Chiara, additional, D’Arcangelo, Francesca, additional, Cattaneo, Roberta, additional, Bonacina, Cristiano, additional, Bernareggi, Monica, additional, Bencini, Serena, additional, Nadalin, Marta, additional, Borelli, Mara, additional, Bellini, Roberto, additional, Salandini, Maria Chiara, additional, and Scarpazza, Paolo, additional

Published
2023
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44. Immune and metabolic alterations in first episode psychosis (FEP) patients

Author

Bocchio-Chiavetto, Luisella, Zanardini, Roberta, Tosato, Sarah, Ventriglia, Mariacarla, Ferrari, Clarissa, Bonetto, Chiara, Lasalvia, Antonio, Giubilini, Franco, Fioritti, Angelo, Pileggi, Francesca, Pratelli, Michela, Pavanati, Michele, Favaro, Angela, De Girolamo, Giovanni, Frisoni, Giovanni Battista, Ruggeri, Mirella, and Gennarelli, Massimo

Published
2018
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47. Minimally invasive versus open pancreatoduodenectomy for pancreatic and peri-ampullary neoplasm (DIPLOMA-2): study protocol for an international multicenter patient-blinded randomized controlled trial

Author

de Graaf, Nine, primary, Emmen, Anouk M.L.H., additional, Ramera, Marco, additional, Björnsson, Bergthor, additional, Boggi, Ugo, additional, Bruna, Caro L., additional, Busch, Olivier R., additional, Daams, Freek, additional, Ferrari, Giovanni, additional, Festen, Sebastiaan, additional, Hilst, Jony van, additional, D'Hondt, Mathieu, additional, Ielpo, Benedetto, additional, Keck, Tobias, additional, Khatkov, Igor E., additional, Koerkamp, Bas Groot, additional, Lips, Daan J., additional, Luyer, Misha D.P., additional, Mieog, J. Sven D., additional, Morelli, Luca, additional, Molenaar, I. Quintus, additional, Santvoort, Hjalmar C van, additional, Sprangers, Mirjam AG, additional, Ferrari, Clarissa, additional, Berkhof, Johannes, additional, Maisonneuve, Patrick, additional, Hilal, Mohammad Abu, additional, and Besselink, Marc G., additional

Published
2023
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49. RISK aversion in Italian forensic and non-forensic patients with schizophrenia spectrum disorders

Author

Canessa, Nicola, primary, Iozzino, Laura, additional, Andreose, Sonia, additional, Castelletti, Luca, additional, Conte, Giovanni, additional, Dvorak, Alexander, additional, Ferrari, Clarissa, additional, Heitzman, Janusz, additional, Macis, Ambra, additional, Markiewicz, Inga, additional, Mattavelli, Giulia, additional, Nicolò, Giuseppe, additional, Picchioni, Marco, additional, Restuccia, Giuseppe, additional, Rivellini, Gianfranco, additional, Teti, Fabio, additional, and de Girolamo, Giovanni, additional

Published
2023
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50. ARTIFICIAL INTELLIGENCE-ASSISTED SMALL BOWEL CAPSULE ENDOSCOPY READING IN PATIENTS WITH SUSPECTED SMALL BOWEL BLEEDING

Author

Piccirelli, Stefania, primary, Hassan, Cesare, additional, Ferrari, Clarissa, additional, Toth, Ervin, additional, Suárez, Begoña González, additional, Keuchel, Martin, additional, McAlindon, Mark, additional, Finta, Adam, additional, Rosztóczy, Andras, additional, Dray, Xavier, additional, Salvi, Daniele, additional, Riccioni, Maria Elena, additional, Benamouzig, Robert, additional, Chattree, Amit, additional, Saurin, Jean-Christophe, additional, Humphries, Adam, additional, Despott, Edward, additional, Murino, Alberto, additional, Johansson, Gabriele, additional, Giordano, Antonio, additional, Baltes, Peter, additional, Sidhu, Reena, additional, Szalai, Milan, additional, Helle, Krisztina, additional, Nemeth, Artur, additional, Nowak, Tanja, additional, Lin, Rong, additional, Costamagna, Guido, additional, and Spada, Cristiano, additional

Published
2023
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