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1. Factors affecting overall survival and disease-free survival after surgery for hepatocellular carcinoma: a nomogram-based prognostic model—a Western European multicenter study

Author

Masuda, Yoshio, Yeo, Mark Hao Xuan, Burdio, Fernando, Sanchez-Velazquez, Patricia, Perez-Xaus, Marc, Pelegrina, Amalia, Koh, Ye Xin, Di Martino, Marcello, Goh, Brian K.P., Tan, Ek Khoon, Teo, Jin Yao, Romano, Fabrizio, Famularo, Simone, Ferrari, Cecilia, Griseri, Guido, Piardi, Tullio, Sommacale, Daniele, Gianotti, Luca, Molfino, Sarah, Baiocchi, Gianluca, and Ielpo, Benedetto

Published
2024
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2. The matrix optimum filter for Low Temperature Detectors dead-time reduction

Author

Borghesi, Matteo, Faverzani, Marco, Ferrari, Cecilia, Ferri, Elena, Giachero, Andrea, Nucciotti, Angelo, and Origo, Luca

Subjects
Physics - Data Analysis, Statistics and Probability, Physics - Instrumentation and Detectors
Abstract

Experiments aiming at high sensitivities usually demand for a very high statistics in order to reach more precise measurements. However, for those exploiting Low Temperature Detectors (LTDs), a high source activity may represent a drawback, if the events rate becomes comparable with the detector characteristic temporal response. Indeed, since commonly used optimum filtering approaches can only process LTDs signals well isolated in time, a non-negligible part of the recorded experimental data-set is discarded and hence constitute the dead-time. In the presented study we demonstrate that, thanks to the matrix optimum filtering approach, the dead-time of an experiment exploiting LTDs can be strongly reduced.

Published
2022
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5. Survival benefit of second line therapies for recurrent hepatocellular carcinoma: repeated hepatectomy, thermoablation and second-line transplant referral in a real life national scenario

Author

Milana, Flavio, Bertacco, Alessandra, De Carlis, Riccardo, Ratti, Francesca, Russolillo, Nadia, Iaria, Maurizio, Razionale, Francesco, Tartaglia, Giuseppe, Ciulli, Cristina, Carissimi, Francesca, Laureiro, Zoe L., Marinelli, Laura, DePeppo, Valerio, Montuori, Mauro, Marchitelli, Ivan, Franceschi, Angelo, Notte, Francesca, Manzoni, Alberto, Cosola, Davide, Corleone, Pio, Fumagalli, Luca, Salvador, Luca, Mantovani, Guido, Cucchetti, Alessandro, Cammarata, Francesco, Conticchio, Maria, Patrone, Renato, Bernasconi, Davide P., Famularo, Simone, Cillo, Umberto, Lauterio, Andrea, Donadon, Matteo, Vitale, Alessandro, Serenari, Matteo, Cipriani, Federica, Fazio, Federico, Giuffrida, Mario, Ardito, Francesco, Dominioni, Tommaso, Garancini, Mattia, Lai, Quirino, Nicolini, Daniele, Molfino, Sarah, Perri, Pasquale, Pinotti, Enrico, Conci, Simone, Ferrari, Cecilia, Zanello, Matteo, Patauner, Stefan, Zimmitti, Giuseppe, Germani, Paola, Chiarelli, Marco, Romano, Maurizio, De Angelis, Michela, La Barba, Giuliano, Troci, Albert, Ferraro, Valentina, Izzo, Francesco, Antonucci, Adelmo, Belli, Andrea, Memeo, Riccardo, Crespi, Michele, Ercolani, Giorgio, Boccia, Luigi, Zanus, Giacomo, Tarchi, Paola, Hilal, Moh'd Abu, Frena, Antonio, Jovine, Elio, Griseri, Guido, Ruzzenente, Andrea, Zago, Mauro, Grazi, Gianluca, Baiocchi, Gian L., Vivarelli, Marco, Rossi, Massimo, Romano, Fabrizio, Maestri, Marcello, Giuliante, Felice, Valle, Raffaele D., Ferrero, Alessandro, Aldrighetti, Luca, De Carlis, Luciano, Cescon, Matteo, and Torzilli, Guido

Published
2023
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6. Benchmarking postoperative outcomes after open liver surgery for cirrhotic patients with hepatocellular carcinoma in a national cohort

Author

Costa, Guido, Milana, Flavio, Fazio, Federico, Ratti, Francesca, Razionale, Francesco, De Peppo, Valerio, Carissimi, Francesca, Paolo Graziano, Giorgio M., Larghi Laurerio, Zoe, Giuffrida, Mario, Cucchetti, Alessandro, Montuori, Mauro, Cosola, Davide, Corleone, Pio, Lazzari, Giovanni, Franceschi, Angelo, Calcagno, Pietro, Salvador, Luca, Manzoni, Alberto, Pennacchi, Luca, Libia, Annarita, Notte, Francesca, Bernasconi, Davide P., Mori, Silvia, Gaudesi, Davide, Famularo, Simone, Russolillo, Nadia, Donadon, Matteo, Cipriani, Federica, Ardito, Francesco, Perri, Pasquale, Giani, Alessandro, De Stefano, Francesca, Lai, Quirino, Molfino, Sarah, Zanello, Matteo, Iaria, Maurizio, La Barba, Giuliano, Pinotti, Enrico, Germani, Paola, Conci, Simone, Ferrari, Cecilia, Fumagalli, Luca, Romano, Maurizio, Antonucci, Adelmo, Zimmitti, Giuseppe, Troci, Albert, Floridi, Antonio, Ferraro, Valentina, Patauner, Stefan, Frena, Antonio, Memeo, Riccardo, Crespi, Michele, Hilal, Mohammed A., Zanus, Giacomo, Chiarelli, Marco, Percivale, Andrea, Ruzzenente, Andrea, Tarchi, Paola, Zago, Mauro, Ercolani, Giorgio, Dalla Valle, Raffaele, Jovine, Elio, Baiocchi, Gian Luca, Rossi, Massimo, Maestri, Marcello, Romano, Fabrizio, Grazi, Gian Luca, Giuliante, Felice, Aldrighetti, Luca, Ferrero, Alessandro, and Torzilli, Guido

Published
2022
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7. The largest western experience on salvage hepatectomy for recurrent hepatocellular carcinoma: propensity score-matched analysis on behalf of He.RC.O.Le.Study Group

Author

Giuffrida, Mario, Russolillo, Nadia, Razionale, Francesco, De Peppo, Valerio, Tomasoni, Matteo, Marchitelli, Ivan, Costa, Guido, Laureiro, Zoe L., Scotti, Mauro, Calcagno, Pietro, Cosola, Davide, Franceschi, Angelo, Manzoni, Alberto, Pennacchi, Luca, Montuori, Mauro, Conticchio, Maria, Ratti, Francesca, Notte, Francesca, Cucchetti, Alessandro, Salvador, Luca, Corleone, Pio, Garancini, Mattia, Ciulli, Cristina, Iaria, Maurizio, Bianchi, Giorgio, Fazio, Federico, Ardito, Francesco, Perri, Pasquale, Pontarolo, Nicholas, Conci, Simone, Donadon, Matteo, Zanello, Matteo, Lai, Quirino, Famularo, Simone, Molfino, Sarah, Sciannamea, Ivano, Fumagalli, Luca, Germani, Paola, Floridi, Antonio, Ferrari, Cecilia, Zimmitti, Giuseppe, Troci, Albert, Zago, Mauro, Ferraro, Valentina, Cipriani, Federica, Patauner, Stefan, La Barba, Giuliano, Romano, Maurizio, Zanus, Giacomo, Ercolani, Giorgio, Frena, Antonio, Aldrighetti, Luca, Memeo, Riccardo, Pinotti, Enrico, Crespi, Michele, Hilal, Moh'd Abu, Griseri, Guido, Tarchi, Paola, Chiarelli, Marco, Antonucci, Adelmo, Baiocchi, Gian L., Romano, Fabrizio, Rossi, Massimo, Jovine, Elio, Torzilli, Guido, Ruzzenente, Andrea, Maestri, Marcello, Grazi, Gian L., Giuliante, Felice, Ferrero, Alessandro, and Dalla Valle, Raffaele

Published
2022
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8. Hepatectomy for Metabolic Associated Fatty Liver Disease (MAFLD) related HCC: Propensity case-matched analysis with viral- and alcohol-related HCC

Author

Conci, Simone, Cipriani, Federica, Donadon, Matteo, Marchitelli, Ivan, Ardito, Francesco, Famularo, Simone, Perri, Pasquale, Iaria, Maurizio, Ansaloni, Luca, Zanello, Matteo, La Barba, Giuliano, Patauner, Stefan, Pinotti, Enrico, Molfino, Sarah, Germani, Paola, Romano, Maurizio, Sciannamea, Ivano, Ferrari, Cecilia, Manzoni, Alberto, Troci, Albert, Fumagalli, Luca, Delvecchio, Antonella, Floridi, Antonio, Memeo, Riccardo, Chiarelli, Marco, Crespi, Michele, Zimmitti, Giuseppe, Griseri, Guido, Antonucci, Adelmo, Zanus, Giacomo, Tarchi, Paola, Baiocchi, Gian Luca, Zago, Mauro, Frena, Antonio, Ercolani, Giorgio, Jovine, Elio, Maestri, Marcello, Valle, Raffaele Dalla, Grazi, Gian Luca, Romano, Fabrizio, Giuliante, Felice, Torzilli, Guido, Aldrighetti, Luca, and Ruzzenente, Andrea

Published
2022
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9. The Effect of a Liver Transplant Program on the Outcomes of Resectable Hepatocellular Carcinoma: A Nationwide Multicenter Analysis

Author

Serenari, Matteo, Lenzi, Jacopo, Cucchetti, Alessandro, Cipriani, Federica, Donadon, Matteo, Ardito, Francesco, Fazio, Federico, Nicolini, Daniele, Iaria, Maurizio, Famularo, Simone, Perri, Pasquale, Ansaloni, Luca, Zanello, Matteo, Lai, Quirino, Conci, Simone, Molfino, Sarah, Ferrari, Cecilia, Germani, Paola, Zago, Mauro, Romano, Maurizio, Zimmitti, Giuseppe, Antonucci, Adelmo, Fumagalli, Luca, Troci, Albert, Ferraro, Valentina, Memeo, Riccardo, Crespi, Michele, Chiarelli, Marco, Ercolani, Giorgio, Hilal, Mohamed A., Zanus, Giacomo, Pinotti, Enrico, Tarchi, Paola, Griseri, Guido, Baiocchi, Gian Luca, Ruzzenente, Andrea, Rossi, Massimo, Jovine, Elio, Maestri, Marcello, Grazi, Gian Luca, Romano, Fabrizio, Dalla Valle, Raffaele, Ravaioli, Matteo, Vivarelli, Marco, Ferrero, Alessandro, Giuliante, Felice, Torzilli, Guido, Aldrighetti, Luca, Cescon, Matteo, Gorgone, Mara, Ratti, Francesca, Costa, Guido, Razionale, Francesco, Russolillo, Nadia, Marinelli, Laura, Giuffrida, Mario, Scotti, Mauro, Garancini, Mattia, De Peppo, Valerio, De Stefano, Francesca, Laureiro, Zoe Larghi, Marchitelli, Ivan, Franceschi, Angelo, Cosola, Davide, Corleone, Pio, Montuori, Mauro, Salvador, Luca, Manzoni, Alberto, La Barba, Giuliano, Calcagno, Pietro, Pennacchi, Luca, and Conticchio, Maria

Published
2023
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10. Curative versus palliative treatments for recurrent hepatocellular carcinoma: a multicentric weighted comparison

Author

Ciulli, Cristina, Giani, Alessandro, Carissimi, Francesca, Costa, Guido, Ratti, Francesca, Cucchetti, Alessandro, Calabrese, Francesco, Cremaschi, Elena, Lazzari, Giovanni, Franceschi, Angelo, Sega, Valentina, Conticchio, Maria, Pennacchi, Luca, Ciola, Michele, Sciannamea, Ivano, De Peppo, Valerio, Famularo, Simone, Donadon, Matteo, Cipriani, Federica, Bernasconi, Davide P., LaBarba, Giuliano, Dominioni, Tommaso, Iaria, Maurizio, Molfino, Sarah, Conci, Simone, Ferrari, Cecilia, Garatti, Marco, Delvecchio, Antonella, Troci, Albert, Patauner, Stefan, Frassani, Silvia, Cosimelli, Maurizio, Zanus, Giacomo, Giuliante, Felice, Jovine, Elio, Valsecchi, Maria G., Grazi, GianLuca, Antonucci, Adelmo, Frena, Antonio, Crespi, Michele, Memeo, Riccardo, Zimmitti, Giuseppe, Griseri, Guido, Ruzzenente, Andrea, Baiocchi, Gianluca, DallaValle, Raffaele, Maestri, Marcello, Ercolani, Giorgio, Aldrighetti, Luca, Torzilli, Guido, and Romano, Fabrizio

Published
2021
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11. Factors Affecting Local and Intra Hepatic Distant Recurrence After Surgery for Hcc: An Alternative Perspective on Microvascular Invasion and Satellitosis – A Western European Multicentre Study

Author

Famularo, Simone, Piardi, Tullio, Molfino, Sarah, Di Martino, Marcello, Ferrari, Cecilia, Ielpo, Benedetto, Diago, Maria Victoria, Giani, Alessandro, Griseri, Guido, Terés, Lara Bianco, Gianotti, Luca, Baiocchi, Gian Luca, Sommacale, Daniele, and Romano, Fabrizio

Published
2021
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12. Hepatocellular carcinoma surgical and oncological trends in a national multicentric population: the HERCOLES experience

Author

Famularo, Simone, Donadon, Matteo, Cipriani, Federica, Ardito, Francesco, Carissimi, Francesca, Perri, Pasquale, Iaria, Maurizio, Dominioni, Tommaso, Zanello, Matteo, Conci, Simone, Molfino, Sarah, LaBarba, Giuliano, Ferrari, Cecilia, Germani, Paola, Patauner, Stefan, Pinotti, Enrico, Lodo, Enrico, Garatti, Marco, Sciannamea, Ivano, Troci, Albert, Conticchio, Maria, Floridi, Antonio, Chiarelli, Marco, Fumagalli, Luca, Memeo, Riccardo, Crespi, Michele, Antonucci, Adelmo, Zimmitti, Giuseppe, Zanus, Giacomo, Zago, Mauro, Frena, Antonio, Tarchi, Paola, Griseri, Guido, Ercolani, Giorgio, Baiocchi, Gian Luca, Ruzzenente, Andrea, Jovine, Elio, Maestri, Marcello, DallaValle, Raffaele, Grazi, Gian Luca, Giuliante, Felice, Aldrighetti, Luca, Torzilli, Guido, and Romano, Fabrizio

Published
2020
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13. Liver Resection vs Nonsurgical Treatments for Patients With Early Multinodular Hepatocellular Carcinoma

Author

Vitale, Alessandro, Romano, Pierluigi, Cillo, Umberto, Lauterio, Andrea, Sangiovanni, Angelo, Cabibbo, Giuseppe, Missale, Gabriele, Marseglia, Mariarosaria, Trevisani, Franco, Foschi, Francesco Giuseppe, Cipriani, Federica, Famularo, Simone, Marra, Fabio, Saitta, Carlo, Serenari, Matteo, Vidili, Gianpaolo, Morisco, Filomena, Caturelli, Eugenio, Mega, Andrea, Pelizzaro, Filippo, Nicolini, Daniele, Ardito, Francesco, Garancini, Mattia, Masotto, Alberto, Baroni, Gianluca Svegliati, Azzaroli, Francesco, Giannini, Edoardo, Perri, Pasquale, Scarinci, Andrea, Fontana, Andrea Pierluigi, Brunetto, Maurizia Rossana, Iaria, Maurizio, Di Marco, Maria, Nardone, Gerardo, Dominioni, Tommaso, Lai, Quirino, Ferrari, Cecilia, Rapaccini, Gian Ludovico, Rodolfo, Sacco, Romano, Maurizio, Conci, Simone, Zoli, Marco, Conticchio, Maria, Zanello, Matteo, Zimmitti, Giuseppe, Fumagalli, Luca, Troci, Albert, Germani, Paola, Gasbarrini, Antonio, La Barba, Giuliano, De Angelis, Michela, Patauner, Stefan, Molfino, Sarah, Zago, Mauro, Pinotti, Enrico, Frigo, Anna Chiara, Baiocchi, Gian Luca, Frena, Antonio, Boccia, Luigi, Ercolani, Giorgio, Tarchi, Paola, Crespi, Michele, Chiarelli, Marco, Abu Hilal, Moh’d, Cescon, Matteo, Memeo, Riccardo, Ruzzenente, Andrea, Zanus, Giacomo, Griseri, Guido, Rossi, Massimo, Maestri, Marcello, Della Valle, Raffaele, Ferrero, Alessandro, Grazi, Gian Luca, Romano, Fabrizio, Giuliante, Felice, Vivarelli, Marco, Jovine, Elio, Torzilli, Guido, Aldrighetti, Luca, and De Carlis, Luciano

Abstract

IMPORTANCE: The 2022 Barcelona Clinic Liver Cancer algorithm currently discourages liver resection (LR) for patients with multinodular hepatocellular carcinoma (HCC) presenting with 2 or 3 nodules that are each 3 cm or smaller. OBJECTIVE: To compare the efficacy of liver resection (LR), percutaneous radiofrequency ablation (PRFA), and transarterial chemoembolization (TACE) in patients with multinodular HCC. DESIGN, SETTING, AND PARTICIPANTS: This cohort study is a retrospective analysis conducted using data from the HE.RC.O.LE.S register (n = 5331) for LR patients and the ITA.LI.CA database (n = 7056) for PRFA and TACE patients. A matching-adjusted indirect comparison (MAIC) method was applied to balance data and potential confounding factors between the 3 groups. Included were patients from multiple centers from 2008 to 2020; data were analyzed from January to December 2023. INTERVENTIONS: LR, PRFA, or TACE. MAIN OUTCOMES AND MEASURES: Survival rates at 1, 3, and 5 years were calculated. Cox MAIC-weighted multivariable analysis and competing risk analysis were used to assess outcomes. RESULTS: A total of 720 patients with early multinodular HCC were included, 543 males (75.4%), 177 females (24.6%), and 350 individuals older than 70 years (48.6%). There were 296 patients in the LR group, 240 who underwent PRFA, and 184 who underwent TACE. After MAIC, LR exhibited 1-, 3-, and 5-year survival rates of 89.11%, 70.98%, and 56.44%, respectively. PRFA showed rates of 94.01%, 65.20%, and 39.93%, while TACE displayed rates of 90.88%, 48.95%, and 29.24%. Multivariable Cox survival analysis in the weighted population showed a survival benefit over alternative treatments (PRFA vs LR: hazard ratio [HR], 1.41; 95% CI, 1.07-1.86; P = .01; TACE vs LR: HR, 1.86; 95% CI, 1.29-2.68; P = .001). Competing risk analysis confirmed a lower risk of cancer-related death in LR compared with PRFA and TACE. CONCLUSIONS AND RELEVANCE: For patients with early multinodular HCC who are ineligible for transplant, LR should be prioritized as the primary therapeutic option, followed by PRFA and TACE when LR is not feasible. These findings provide valuable insights for clinical decision-making in this patient population.

Published
2024
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14. Factors affecting overall survival and disease-free survival after surgery for hepatocellular carcinoma: a nomogram-based prognostic model—a Western European multicenter study

Author

Masuda, Yoshio, primary, Yeo, Mark Hao Xuan, additional, Burdio, Fernando, additional, Sanchez-Velazquez, Patricia, additional, Perez-Xaus, Marc, additional, Pelegrina, Amalia, additional, Koh, Ye Xin, additional, Di Martino, Marcello, additional, Goh, Brian K.P., additional, Tan, Ek Khoon, additional, Teo, Jin Yao, additional, Romano, Fabrizio, additional, Famularo, Simone, additional, Ferrari, Cecilia, additional, Griseri, Guido, additional, Piardi, Tullio, additional, Sommacale, Daniele, additional, Gianotti, Luca, additional, Molfino, Sarah, additional, Baiocchi, Gianluca, additional, and Ielpo, Benedetto, additional

Published
2023
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15. Survival benefit of second line therapies for recurrent hepatocellular carcinoma: repeated hepatectomy, thermoablation and second-line transplant referral in a real life national scenario

Author

Famularo, Simone, primary, Cillo, Umberto, additional, Lauterio, Andrea, additional, Donadon, Matteo, additional, Vitale, Alessandro, additional, Serenari, Matteo, additional, Cipriani, Federica, additional, Fazio, Federico, additional, Giuffrida, Mario, additional, Ardito, Francesco, additional, Dominioni, Tommaso, additional, Garancini, Mattia, additional, Lai, Quirino, additional, Nicolini, Daniele, additional, Molfino, Sarah, additional, Perri, Pasquale, additional, Pinotti, Enrico, additional, Conci, Simone, additional, Ferrari, Cecilia, additional, Zanello, Matteo, additional, Patauner, Stefan, additional, Zimmitti, Giuseppe, additional, Germani, Paola, additional, Chiarelli, Marco, additional, Romano, Maurizio, additional, De Angelis, Michela, additional, La Barba, Giuliano, additional, Troci, Albert, additional, Ferraro, Valentina, additional, Izzo, Francesco, additional, Antonucci, Adelmo, additional, Belli, Andrea, additional, Memeo, Riccardo, additional, Crespi, Michele, additional, Ercolani, Giorgio, additional, Boccia, Luigi, additional, Zanus, Giacomo, additional, Tarchi, Paola, additional, Hilal, Moh'd Abu, additional, Frena, Antonio, additional, Jovine, Elio, additional, Griseri, Guido, additional, Ruzzenente, Andrea, additional, Zago, Mauro, additional, Grazi, Gianluca, additional, Baiocchi, Gian L., additional, Vivarelli, Marco, additional, Rossi, Massimo, additional, Romano, Fabrizio, additional, Maestri, Marcello, additional, Giuliante, Felice, additional, Valle, Raffaele D., additional, Ferrero, Alessandro, additional, Aldrighetti, Luca, additional, De Carlis, Luciano, additional, Cescon, Matteo, additional, Torzilli, Guido, additional, Milana, Flavio, additional, Bertacco, Alessandra, additional, De Carlis, Riccardo, additional, Ratti, Francesca, additional, Russolillo, Nadia, additional, Iaria, Maurizio, additional, Razionale, Francesco, additional, Tartaglia, Giuseppe, additional, Ciulli, Cristina, additional, Carissimi, Francesca, additional, Laureiro, Zoe L., additional, Marinelli, Laura, additional, DePeppo, Valerio, additional, Montuori, Mauro, additional, Marchitelli, Ivan, additional, Franceschi, Angelo, additional, Notte, Francesca, additional, Manzoni, Alberto, additional, Cosola, Davide, additional, Corleone, Pio, additional, Fumagalli, Luca, additional, Salvador, Luca, additional, Mantovani, Guido, additional, Cucchetti, Alessandro, additional, Cammarata, Francesco, additional, Conticchio, Maria, additional, Patrone, Renato, additional, and Bernasconi, Davide P., additional

Published
2023
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16. Early versus Later Anticoagulation for Stroke with Atrial Fibrillation

Author

Fischer, Urs, primary, Koga, Masatoshi, additional, Strbian, Daniel, additional, Branca, Mattia, additional, Abend, Stefanie, additional, Trelle, Sven, additional, Paciaroni, Maurizio, additional, Thomalla, Götz, additional, Michel, Patrik, additional, Nedeltchev, Krassen, additional, Bonati, Leo H., additional, Ntaios, George, additional, Gattringer, Thomas, additional, Sandset, Else-Charlotte, additional, Kelly, Peter, additional, Lemmens, Robin, additional, Sylaja, P.N., additional, Aguiar de Sousa, Diana, additional, Bornstein, Natan M., additional, Gdovinova, Zuzana, additional, Yoshimoto, Takeshi, additional, Tiainen, Marjaana, additional, Thomas, Helen, additional, Krishnan, Manju, additional, Shim, Gek C., additional, Gumbinger, Christoph, additional, Vehoff, Jochen, additional, Zhang, Liqun, additional, Matsuzono, Kosuke, additional, Kristoffersen, Espen, additional, Desfontaines, Philippe, additional, Vanacker, Peter, additional, Alonso, Angelika, additional, Yakushiji, Yusuke, additional, Kulyk, Caterina, additional, Hemelsoet, Dimitri, additional, Poli, Sven, additional, Paiva Nunes, Ana, additional, Caracciolo, Nicoletta, additional, Slade, Peter, additional, Demeestere, Jelle, additional, Salerno, Alexander, additional, Kneihsl, Markus, additional, Kahles, Timo, additional, Giudici, Daria, additional, Tanaka, Kanta, additional, Räty, Silja, additional, Hidalgo, Rea, additional, Werring, David J., additional, Göldlin, Martina, additional, Arnold, Marcel, additional, Ferrari, Cecilia, additional, Beyeler, Seraina, additional, Fung, Christian, additional, Weder, Bruno J., additional, Tatlisumak, Turgut, additional, Fenzl, Sabine, additional, Rezny-Kasprzak, Beata, additional, Hakim, Arsany, additional, Salanti, Georgia, additional, Bassetti, Claudio, additional, Gralla, Jan, additional, Seiffge, David J., additional, Horvath, Thomas, additional, and Dawson, Jesse, additional

Published
2023
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18. Effect of managed transition on mental health outcomes for young people at the child-adult mental health service boundary:A randomised clinical trial

Author

Singh, S. P., Tuomainen, H., Bouliotis, G., Canaway, A., De Girolamo, G., Dieleman, G. C., Franić, T., Madan, J., Maras, A., McNicholas, F., Paul, M., Purper-Ouakil, D., Santosh, P., Schulze, U. M.E., Street, C., Tremmery, S., Verhulst, F. C., Wells, P., Wolke, D., Warwick, J., Tah, Priya, Griffin, James, Appleton, Rebecca, Heaney, Natalie, Lievesley, Kate, Mastroianni, Mathilde, Singh, Jatinder, Adams, Laura, Signorini, Giulia, Ferrari, Alessandro, Gheza, Elisa, Ferrari, Cecilia, Rivolta, Laura, Levi, Flavia, Cataldo, Maria, Manenti, Lidia, Morini, Giorgia, Pastore, Adriana, Stagni, Pamela, Toselli, Cecilia, Varvara, Pamela, Russet, Frédérick, Maurice, Virginie, Humbertclaude, Véronique, Bodegom, Larissa S.Van, Overbeek, Mathilde M., Gerritsen, Suzanne E., Saam, Melanie, Breuninger, Ulrike, Hendrickx, Gaëlle, Singh, S. P., Tuomainen, H., Bouliotis, G., Canaway, A., De Girolamo, G., Dieleman, G. C., Franić, T., Madan, J., Maras, A., McNicholas, F., Paul, M., Purper-Ouakil, D., Santosh, P., Schulze, U. M.E., Street, C., Tremmery, S., Verhulst, F. C., Wells, P., Wolke, D., Warwick, J., Tah, Priya, Griffin, James, Appleton, Rebecca, Heaney, Natalie, Lievesley, Kate, Mastroianni, Mathilde, Singh, Jatinder, Adams, Laura, Signorini, Giulia, Ferrari, Alessandro, Gheza, Elisa, Ferrari, Cecilia, Rivolta, Laura, Levi, Flavia, Cataldo, Maria, Manenti, Lidia, Morini, Giorgia, Pastore, Adriana, Stagni, Pamela, Toselli, Cecilia, Varvara, Pamela, Russet, Frédérick, Maurice, Virginie, Humbertclaude, Véronique, Bodegom, Larissa S.Van, Overbeek, Mathilde M., Gerritsen, Suzanne E., Saam, Melanie, Breuninger, Ulrike, and Hendrickx, Gaëlle

Abstract

Background Poor transition planning contributes to discontinuity of care at the child-adult mental health service boundary (SB), adversely affecting mental health outcomes in young people (YP). The aim of the study was to determine whether managed transition (MT) improves mental health outcomes of YP reaching the child/adolescent mental health service (CAMHS) boundary compared with usual care (UC). Methods A two-arm cluster-randomised trial (ISRCTN83240263 and NCT03013595) with clusters allocated 1:2 between MT and UC. Recruitment took place in 40 CAMHS (eight European countries) between October 2015 and December 2016.

Published
2023

19. Demographic, clinical, and service-use characteristics related to the clinician’s recommendation to transition from child to adult mental health services

Author

Gerritsen, S. E., van Bodegom, L. S., Dieleman, G. C., Overbeek, M. M., Verhulst, F. C., Wolke, Dieter, Rizopoulos, D., Appleton, R., van Amelsvoort, T. A. M. J., Bodier Rethore, C., Bonnet-Brilhault, F., Charvin, I., Da Fonseca, D., Davidović, N., Dodig-Ćurković, K., Ferrari, A., Fiori, F., Franić, T., Gatherer, C., de Girolamo, G., Heaney, N., Hendrickx, G., Jardri, R., Kolozsvari, A., Lida-Pulik, H., Lievesley, K., Madan, J., Mastroianni, M., Maurice, V., McNicholas, F., Nacinovich, R., Parenti, A., Paul, M., Purper-Ouakil, D., Rivolta, L., de Roeck, V., Russet, F., Saam, M. C., Sagar-Ouriaghli, I., Santosh, P. J., Sartor, A., Schulze, U. M. E., Scocco, P., Signorini, G., Singh, S. P., Singh, J., Speranza, M., Stagi, P., Stagni, P., Street, C., Tah, P., Tanase, E., Tremmery, S., Tuffrey, A., Tuomainen, H., Walker, L., Wilson, A., Maras, A., Adams, Laura, Allibrio, Giovanni, Armando, Marco, Aslan, Sonja, Baccanelli, Nadia, Balaudo, Monica, Bergamo, Fabia, Bertani, Angelo, Berriman, Jo, Boon, Albert, Braamse, Karen, Breuninger, Ulrike, Buttiglione, Maura, Buttle, Sarah, Schandrin, Aurélie, Cammarano, Marco, Canaway, Alastair, Cantini, Fortunata, Cappellari, Cristiano, Carenini, Marta, Carrà, Giuseppe, Ferrari, Cecilia, Chianura, Krizia, Coleman, Philippa, Colonna, Annalisa, Conese, Patrizia, Costanzo, Raffaella, Daffern, Claire, Danckaerts, Marina, de Giacomo, Andrea, Ermans, Jean-Pierre, Farmer, Alan, Fegert, Jörg M., Ferrari, Sabrina, Galea, Giuliana, Gatta, Michela, Gheza, Elisa, Goglia, Giacomo, Grandetto, MariaRosa, Griffin, James, Levi, Flavia Micol, Humbertclaude, Véronique, Ingravallo, Nicola, Invernizzi, Roberta, Kelly, Caoimhe, Killilea, Meghan, Kirwan, James, Klockaerts, Catherine, Kovač, Vlatka, Liew, Ashley, Lippens, Christel, Macchi, Francesca, Manenti, Lidia, Margari, Francesco, Margari, Lucia, Martinelli, Paola, McFadden, Leighton, Menghini, Deny, Miller, Sarah, Monzani, Emiliano, Morini, Giorgia, Mutafov, Todor, O’Hara, Lesley, Negrinotti, Cristina, Nelis, Emmanuel, Neri, Francesca, Nikolova, Paulina, Nossa, Marzia, Cataldo, Maria Giulia, Noterdaeme, Michele, Operto, Francesca, Panaro, Vittoria, Pastore, Adriana, Pemmaraju, Vinuthna, Pepermans, Ann, Petruzzelli, Maria Giuseppina, Presicci, Anna, Prigent, Catherine, Rinaldi, Francesco, Riva, Erika, Roekens, Anne, Rogers, Ben, Ronzini, Pablo, Sakar, Vehbi, Salvetti, Selena, Martinelli, Ottaviano, Sandhu, Tanveer, Schepker, Renate, Siviero, Marco, Slowik, Michael, Smyth, Courtney, Conti, Patrizia, Spadone, Maria Antonietta, Starace, Fabrizio, Stoppa, Patrizia, Tansini, Lucia, Toselli, Cecilia, Trabucchi, Guido, Tubito, Maria, van Dam, Arno, van Gutschoven, Hanne, van West, Dirk, Vanni, Fabio, Vannicola, Chiara, Varuzza, Cristiana, Varvara, Pamela, Ventura, Patrizia, Vicari, Stefano, Vicini, Stefania, von Bentzel, Carolin, Wells, Philip, Williams, Beata, Zabarella, Marina, Zamboni, Anna, Zanetti, Edda, HASH(0x5651c9679ff8), RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, MUMC+: MA Med Staf Spec Psychiatrie (9), Child and Adolescent Psychiatry / Psychology, Epidemiology, Clinical Child and Family Studies, LEARN! - Child rearing, APH - Mental Health, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Lille Neurosciences & Cognition - U 1172 (LilNCog), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier de Versailles André Mignot (CHV), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Lille, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, The MILESTONE project was funded by EU FP7 programme under grant number 602442. SPS is part-funded by the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care West Midlands (NIHR CLAHRC WM), now recommissioned as NIHR Applied Research Collaboration West Midlands. The views expressed in this publication are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. PS is the co-inventor of the HealthTrackerTM and is the Chief Executive Officer and shareholder in HealthTracker Ltd. FF is a Chief Technical Officer and AK is the Chief Finance Officer employed by HealthTracker Ltd, respectively. FCV publishes the Dutch translations of ASEBA, from which he receives remuneration. AM was a speaker and advisor for Neurim, Shire, Infectopharm, and Lilly (all not related to transition research)., European Project: 602442,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,MILESTONE(2014), The Milestone Consortium, Gerritsen, S, van Bodegom, L, Dieleman, G, Overbeek, M, Verhulst, F, Wolke, D, Rizopoulos, D, Appleton, R, van Amelsvoort, T, Bodier Rethore, C, Bonnet-Brilhault, F, Charvin, I, Da Fonseca, D, Davidovic, N, Dodig-Curkovic, K, Ferrari, A, Fiori, F, Franic, T, Gatherer, C, de Girolamo, G, Heaney, N, Hendrickx, G, Jardri, R, Kolozsvari, A, Lida-Pulik, H, Lievesley, K, Madan, J, Mastroianni, M, Maurice, V, Mcnicholas, F, Nacinovich, R, Parenti, A, Paul, M, Purper-Ouakil, D, Rivolta, L, de Roeck, V, Russet, F, Saam, M, Sagar-Ouriaghli, I, Santosh, P, Sartor, A, Schulze, U, Scocco, P, Signorini, G, Singh, S, Singh, J, Speranza, M, Stagi, P, Stagni, P, Street, C, Tah, P, Tanase, E, Tremmery, S, Tuffrey, A, Tuomainen, H, Walker, L, Wilson, A, Maras, A, Adams, L, Allibrio, G, Armando, M, Aslan, S, Baccanelli, N, Balaudo, M, Bergamo, F, Bertani, A, Berriman, J, Boon, A, Braamse, K, Breuninger, U, Buttiglione, M, Buttle, S, Schandrin, A, Cammarano, M, Canaway, A, Cantini, F, Cappellari, C, Carenini, M, Carra, G, Ferrari, C, Chianura, K, Coleman, P, Colonna, A, Conese, P, Costanzo, R, Daffern, C, Danckaerts, M, de Giacomo, A, Ermans, J, Farmer, A, Fegert, J, Ferrari, S, Galea, G, Gatta, M, Gheza, E, Goglia, G, Grandetto, M, Griffin, J, Levi, F, Humbertclaude, V, Ingravallo, N, Invernizzi, R, Kelly, C, Killilea, M, Kirwan, J, Klockaerts, C, Kovac, V, Liew, A, Lippens, C, Macchi, F, Manenti, L, Margari, F, Margari, L, Martinelli, P, Mcfadden, L, Menghini, D, Miller, S, Monzani, E, Morini, G, Mutafov, T, O'Hara, L, Negrinotti, C, Nelis, E, Neri, F, Nikolova, P, Nossa, M, Cataldo, M, Noterdaeme, M, Operto, F, Panaro, V, Pastore, A, Pemmaraju, V, Pepermans, A, Petruzzelli, M, Presicci, A, Prigent, C, Rinaldi, F, Riva, E, Roekens, A, Rogers, B, Ronzini, P, Sakar, V, Salvetti, S, Martinelli, O, Sandhu, T, Schepker, R, Siviero, M, Slowik, M, Smyth, C, Conti, P, Spadone, M, Starace, F, Stoppa, P, Tansini, L, Toselli, C, Trabucchi, G, Tubito, M, van Dam, A, van Gutschoven, H, van West, D, Vanni, F, Vannicola, C, Varuzza, C, Varvara, P, Ventura, P, Vicari, S, Vicini, S, von Bentzel, C, Wells, P, Williams, B, Zabarella, M, Zamboni, A, and Zanetti, E

Subjects
Adult mental health service, Adult, Mental Health Services, Parents, Health (social science), Child and adolescent mental health service, Social Psychology, RJ, Epidemiology, ADOLESCENT, Child and adolescent mental health services, Adult mental health services, Young adults, Transition, SDG 3 - Good Health and Well-being, PEOPLE, SCHIZOPHRENIA, Humans, Family, Child, Demography, Mental Disorders, CARE, Psychiatry and Mental health, Young adult, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, RA
Abstract

Purpose The service configuration with distinct child and adolescent mental health services (CAMHS) and adult mental health services (AMHS) may be a barrier to continuity of care. Because of a lack of transition policy, CAMHS clinicians have to decide whether and when a young person should transition to AMHS. This study describes which characteristics are associated with the clinicians’ advice to continue treatment at AMHS. Methods Demographic, family, clinical, treatment, and service-use characteristics of the MILESTONE cohort of 763 young people from 39 CAMHS in Europe were assessed using multi-informant and standardized assessment tools. Logistic mixed models were fitted to assess the relationship between these characteristics and clinicians’ transition recommendations. Results Young people with higher clinician-rated severity of psychopathology scores, with self- and parent-reported need for ongoing treatment, with lower everyday functional skills and without self-reported psychotic experiences were more likely to be recommended to continue treatment. Among those who had been recommended to continue treatment, young people who used psychotropic medication, who had been in CAMHS for more than a year, and for whom appropriate AMHS were available were more likely to be recommended to continue treatment at AMHS. Young people whose parents indicated a need for ongoing treatment were more likely to be recommended to stay in CAMHS. Conclusion Although the decision regarding continuity of treatment was mostly determined by a small set of clinical characteristics, the recommendation to continue treatment at AMHS was mostly affected by service-use related characteristics, such as the availability of appropriate services.

Published
2022

20. Hepatocellular carcinoma surgical and oncological trends in a national multicentric population: the HERCOLES experience

Author

Famularo, Simone, Donadon, Matteo, Cipriani, Federica, Ardito, Francesco, Carissimi, Francesca, Perri, Pasquale, Iaria, Maurizio, Dominioni, Tommaso, Zanello, Matteo, Conci, Simone, Molfino, Sarah, LaBarba, Giuliano, Ferrari, Cecilia, Germani, Paola, Patauner, Stefan, Pinotti, Enrico, Lodo, Enrico, Garatti, Marco, Sciannamea, Ivano, Troci, Albert, Conticchio, Maria, Floridi, Antonio, Chiarelli, Marco, Fumagalli, Luca, Memeo, Riccardo, Crespi, Michele, Antonucci, Adelmo, Zimmitti, Giuseppe, Zanus, Giacomo, Zago, Mauro, Frena, Antonio, Tarchi, Paola, Griseri, Guido, Ercolani, Giorgio, Baiocchi, Gian Luca, Ruzzenente, Andrea, Jovine, Elio, Maestri, Marcello, DallaValle, Raffaele, Grazi, Gian Luca, Giuliante, Felice, Aldrighetti, Luca, Torzilli, Guido, and Romano, Fabrizio

Abstract

Liver surgery is the first line treatment for hepatocarcinoma. Hepatocarcinoma Recurrence on the Liver Study (HERCOLES) Group was established in 2018 with the goal to create a network of Italian centres sharing data and promoting scientific research on hepatocellular carcinoma (HCC) in the surgical field. This is the first national report that analyses the trends in surgical and oncological outcomes. Register data were collected by 22 Italian centres between 2008 and 2018. One hundred sixty-four variables were collected, regarding liver functional status, tumour burden, radiological, intraoperative and perioperative data, histological features and oncological follow-up. 2381 Patients were enrolled. Median age was 70 (IQR 63–75) years old. Cirrhosis was present in 1491 patients (62.6%), and Child-A were 89.9% of cases. HCC was staged as BCLC0-A in almost 50% of cases, while BCLC B and C were 20.7% and 17.9% respectively. Major liver resections were 481 (20.2%), and laparoscopy was employed in 753 (31.6%) cases. Severe complications occurred only in 5%. Postoperative ascites was recorded in 10.5% of patients, while posthepatectomy liver failure was observed in 4.9%. Ninety-day mortality was 2.5%. At 5 years, overall survival was 66.1% and disease-free survival was 40.9%. Recurrence was intrahepatic in 74.6% of cases. Redo-surgery and thermoablation for recurrence were performed up to 32% of cases. This is the most updated Italian report of the national experience in surgical treatment for HCC. This dataset is consistently allowing the participating centres in creating multicentric analysis which are already running with a very large sample size and strong power.

Published
2024
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22. Single Large Hepatocellular Carcinoma > 5 cm with Surgical Indication: Is it Mandatory a Major Hepatectomy? A Propensity-score Weighted Analysis

Author

Garancini, M., primary, Ferrero, A., additional, De Carlis, L., additional, Grazi, G.L., additional, Giuliante, F., additional, Cillo, U., additional, Cescon, M., additional, Valle, R. Dalla, additional, Vivarelli, M., additional, Torzilli, G., additional, Aldrighetti, L., additional, Romano, Fabrizio, additional, Donadon, Matteo, additional, Cipriani, Federica, additional, Serenari, Matteo, additional, Ardito, Francesco, additional, Lauterio, Andrea, additional, Vitale, Alessandro, additional, Fazio, Federico, additional, Nicolini, Daniele, additional, Perri, Pasquale, additional, Iaria, Giuseppe, additional, Famularo, Simone, additional, Dominioni, Tommaso, additional, Zanello, Matteo, additional, Lai, Quirino, additional, Conci, Simone, additional, Molfino, Sarah, additional, Ferrari, Cecilia, additional, Germani, Paola, additional, Scotti, Mauro Alessandro, additional, Zago, Mauro, additional, Zimmitti, Giuseppe, additional, La Barba Maurizio Romano, Giuliano, additional, Sciannamea, Ivano, additional, Fumagalli, Luca, additional, Troci, Albert, additional, Ferraro, Valentina, additional, Memeo, Riccardo, additional, Crespi, Michele, additional, Chiarelli, Marco, additional, Antonucci, Adelmo, additional, Zanus, Giacomo, additional, Ercolani, Giorgio, additional, Hilal, Moh’d Abu, additional, Pinotti, Enrico, additional, Tarchi, Paola, additional, Griseri, Guido, additional, Baiocchi, Gian Luca, additional, Ruzzenente, Andrea, additional, Rossi, Massimo, additional, Jovine, Elio, additional, and Maestri, Marcello, additional

Published
2023
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23. Cohort profile

Author

Gerritsen, Suzanne E., Maras, Athanasios, van Bodegom, Larissa S., Overbeek, Mathilde M., Verhulst, Frank C., Wolke, Dieter, Appleton, Rebecca, Bertani, Angelo, Cataldo, Maria G., Conti, Patrizia, Da Fonseca, David, Davidović, Nikolina, Dodig-Ćurković, Katarina, Ferrari, Cecilia, Fiori, Federico, Franić, Tomislav, Gatherer, Charlotte, De Girolamo, Giovanni, Heaney, Natalie, Hendrickx, Gaëlle, Kolozsvari, Alfred, Levi, Flavia Micol, Lievesley, Kate, Madan, Jason, Martinelli, Ottaviano, Mastroianni, Mathilde, Maurice, Virginie, McNicholas, Fiona, O'Hara, Lesley, Paul, Moli, Purper-Ouakil, Diane, de Roeck, Veronique, Russet, Frédérick, Saam, Melanie C., Sagar-Ouriaghli, Ilyas, Santosh, Paramala J., Sartor, Anne, Schandrin, Aurélie, Schulze, Ulrike M. E., Signorini, Giulia, Singh, Swaran P., Singh, Jatinder, Street, Cathy, Tah, Priya, Tanase, Elena, Tremmery, Sabine, Tuffrey, Amanda, Tuomainen, Helena, van Amelsvoort, Therese A. M. J., Wilson, Anna, Walker, Leanne, Dieleman, Gwen C., Adams, Laura, Allibrio, Giovanni, Armando, Marco, Aslan, Sonja, Baccanelli, Nadia, Balaudo, Monica, Bergamo, Fabia, Berriman, Jo, Rethore, Chrystèle Bodier, Bonnet-Brilhault, Frédérique, Boon, Albert, Braamse, Karen, Breuninger, Ulrike, Buttiglione, Maura, Buttle, Sarah, Cammarano, Marco, Canaway, Alastair, Cantini, Fortunata, Cappellari, Cristiano, Carenini, Marta, Carrà, Giuseppe, Charvin, Isabelle, Chianura, Krizia, Coleman, Philippa, Colonna, Annalisa, Conese, Patrizia, Costanzo, Raffaella, Daffern, Claire, Danckaerts, Marina, Giacomo, Andrea de, Dineen, Peter, Ermans, Jean-Pierre, Farmer, Alan, Fegert, Jörg M., Ferrari, Alessandro, Ferrari, Sabrina, Galea, Giuliana, Gatta, Michela, Gheza, Elisa, Goglia, Giacomo, Grandetto, MariaRosa, Griffin, James, Healy, Elaine, Holmes, Keith, Humbertclaude, Véronique, Ingravallo, Nicola, Invernizzi, Roberta, Jardri, Renaud, Keeley, Helen, Kelly, Caoimhe, Killilea, Meghan, Kirwan, James, Klockaerts, Catherine, Kovač, Vlatka, Lida-Pulik, Hélène, Liew, Ashley, Lippens, Christel, Lynch, Fionnuala, Macchi, Francesca, Manenti, Lidia, Margari, Francesco, Margari, Lucia, Martinelli, Paola, McDonald, James, McFadden, Leighton, Menghini, Deny, Migone, Maria, Miller, Sarah, Monzani, Emiliano, Morini, Giorgia, Mutafov, Todor, Nacinovich, Renata, Negrinotti, Cristina, Nelis, Emmanuel, Neri, Francesca, Nikolova, Paulina, Nossa, Marzia, Noterdaeme, Michele, Operto, Francesca, Panaro, Vittoria, Parenti, Aesa, Pastore, Adriana, Pemmaraju, Vinuthna, Pepermans, Ann, Petruzzelli, Maria Giuseppina, Presicci, Anna, Prigent, Catherine, Rinaldi, Francesco, Riva, Erika, Rivolta, Laura, Roekens, Anne, Rogers, Ben, Ronzini, Pablo, Sakar, Vehbi, Salvetti, Selena, Sandhu, Tanveer, Schepker, Renate, Scocco, Paolo, Siviero, Marco, Slowik, Michael, Smyth, Courtney, Spadone, Maria Antonietta, Speranza, Mario, Stagi, Paolo, Stagni, Pamela, Starace, Fabrizio, Stoppa, Patrizia, Tansini, Lucia, Toselli, Cecilia, Trabucchi, Guido, Tubito, Maria, Dam, Arno van, Gutschoven, Hanne Van, West, Dirk van, Vanni, Fabio, Vannicola, Chiara, Varuzza, Cristiana, Varvara, Pamela, Ventura, Patrizia, Vicari, Stefano, Vicini, Stefania, Bentzel, Carolin von, Wells, Philip, Williams, Beata, Zabarella, Marina, Zamboni, Anna, Zanetti, Edda, RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, MUMC+: MA Med Staf Spec Psychiatrie (9), Child and Adolescent Psychiatry / Psychology, Clinical Child and Family Studies, LEARN! - Child rearing, and APH - Mental Health

Subjects
Adult, Internationality, SAMPLE, RJ, child & adolescent psychiatry, ADOLESCENT, Jugendpsychiatrie, Cohort Studies, SDG 3 - Good Health and Well-being, ddc:150, QUALITY-OF-LIFE, Psychiatrische Versorgung, Child psychiatry, Humans, Prospective Studies, SCALE, Demography, Retrospective Studies, Psychiatry, Internationalität, OUTCOMES, DDC 150 / Psychology, Adolescent psychiatry, international health services, General Medicine, WHOQOL-BREF, Europe, Mental Health, Mental health services, CROSS, Adolescent Health Services, EXPERIENCE, Kinderpsychiatrie, adult psychiatry, RA, TRANSITION, RC
Abstract

PurposeThe presence of distinct child and adolescent mental health services (CAMHS) and adult mental health services (AMHS) impacts continuity of mental health treatment for young people. However, we do not know the extent of discontinuity of care in Europe nor the effects of discontinuity on the mental health of young people. Current research is limited, as the majority of existing studies are retrospective, based on small samples or used non-standardised information from medical records. The MILESTONE prospective cohort study aims to examine associations between service use, mental health and other outcomes over 24 months, using information from self, parent and clinician reports.ParticipantsSeven hundred sixty-three young people from 39 CAMHS in 8 European countries, their parents and CAMHS clinicians who completed interviews and online questionnaires and were followed up for 2 years after reaching the upper age limit of the CAMHS they receive treatment at.Findings to dateThis cohort profile describes the baseline characteristics of the MILESTONE cohort. The mental health of young people reaching the upper age limit of their CAMHS varied greatly in type and severity: 32.8% of young people reported clinical levels of self-reported problems and 18.6% were rated to be ‘markedly ill’, ‘severely ill’ or ‘among the most extremely ill’ by their clinician. Fifty-seven per cent of young people reported psychotropic medication use in the previous half year.Future plansAnalysis of longitudinal data from the MILESTONE cohort will be used to assess relationships between the demographic and clinical characteristics of young people reaching the upper age limit of their CAMHS and the type of care the young person uses over the next 2 years, such as whether the young person transitions to AMHS. At 2 years follow-up, the mental health outcomes of young people following different care pathways will be compared.Trial registration numberNCT03013595., publishedVersion

Published
2021

24. The largest western experience on salvage hepatectomy for recurrent hepatocellular carcinoma: propensity score-matched analysis on behalf of He.RC.O.Le.Study Group

Author

Iaria, Maurizio, primary, Bianchi, Giorgio, additional, Fazio, Federico, additional, Ardito, Francesco, additional, Perri, Pasquale, additional, Pontarolo, Nicholas, additional, Conci, Simone, additional, Donadon, Matteo, additional, Zanello, Matteo, additional, Lai, Quirino, additional, Famularo, Simone, additional, Molfino, Sarah, additional, Sciannamea, Ivano, additional, Fumagalli, Luca, additional, Germani, Paola, additional, Floridi, Antonio, additional, Ferrari, Cecilia, additional, Zimmitti, Giuseppe, additional, Troci, Albert, additional, Zago, Mauro, additional, Ferraro, Valentina, additional, Cipriani, Federica, additional, Patauner, Stefan, additional, La Barba, Giuliano, additional, Romano, Maurizio, additional, Zanus, Giacomo, additional, Ercolani, Giorgio, additional, Frena, Antonio, additional, Aldrighetti, Luca, additional, Memeo, Riccardo, additional, Pinotti, Enrico, additional, Crespi, Michele, additional, Hilal, Moh'd Abu, additional, Griseri, Guido, additional, Tarchi, Paola, additional, Chiarelli, Marco, additional, Antonucci, Adelmo, additional, Baiocchi, Gian L., additional, Romano, Fabrizio, additional, Rossi, Massimo, additional, Jovine, Elio, additional, Torzilli, Guido, additional, Ruzzenente, Andrea, additional, Maestri, Marcello, additional, Grazi, Gian L., additional, Giuliante, Felice, additional, Ferrero, Alessandro, additional, Dalla Valle, Raffaele, additional, Giuffrida, Mario, additional, Russolillo, Nadia, additional, Razionale, Francesco, additional, De Peppo, Valerio, additional, Tomasoni, Matteo, additional, Marchitelli, Ivan, additional, Costa, Guido, additional, Laureiro, Zoe L., additional, Scotti, Mauro, additional, Calcagno, Pietro, additional, Cosola, Davide, additional, Franceschi, Angelo, additional, Manzoni, Alberto, additional, Pennacchi, Luca, additional, Montuori, Mauro, additional, Conticchio, Maria, additional, Ratti, Francesca, additional, Notte, Francesca, additional, Cucchetti, Alessandro, additional, Salvador, Luca, additional, Corleone, Pio, additional, Garancini, Mattia, additional, and Ciulli, Cristina, additional

Published
2022
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25. Benchmarking postoperative outcomes after open liver surgery for cirrhotic patients with hepatocellular carcinoma in a national cohort

Author

Famularo, Simone, primary, Russolillo, Nadia, additional, Donadon, Matteo, additional, Cipriani, Federica, additional, Ardito, Francesco, additional, Perri, Pasquale, additional, Giani, Alessandro, additional, De Stefano, Francesca, additional, Lai, Quirino, additional, Molfino, Sarah, additional, Zanello, Matteo, additional, Iaria, Maurizio, additional, La Barba, Giuliano, additional, Pinotti, Enrico, additional, Germani, Paola, additional, Conci, Simone, additional, Ferrari, Cecilia, additional, Fumagalli, Luca, additional, Romano, Maurizio, additional, Antonucci, Adelmo, additional, Zimmitti, Giuseppe, additional, Troci, Albert, additional, Floridi, Antonio, additional, Ferraro, Valentina, additional, Patauner, Stefan, additional, Frena, Antonio, additional, Memeo, Riccardo, additional, Crespi, Michele, additional, Hilal, Mohammed A., additional, Zanus, Giacomo, additional, Chiarelli, Marco, additional, Percivale, Andrea, additional, Ruzzenente, Andrea, additional, Tarchi, Paola, additional, Zago, Mauro, additional, Ercolani, Giorgio, additional, Dalla Valle, Raffaele, additional, Jovine, Elio, additional, Baiocchi, Gian Luca, additional, Rossi, Massimo, additional, Maestri, Marcello, additional, Romano, Fabrizio, additional, Grazi, Gian Luca, additional, Giuliante, Felice, additional, Aldrighetti, Luca, additional, Ferrero, Alessandro, additional, Torzilli, Guido, additional, Costa, Guido, additional, Milana, Flavio, additional, Fazio, Federico, additional, Ratti, Francesca, additional, Razionale, Francesco, additional, De Peppo, Valerio, additional, Carissimi, Francesca, additional, Paolo Graziano, Giorgio M., additional, Larghi Laurerio, Zoe, additional, Giuffrida, Mario, additional, Cucchetti, Alessandro, additional, Montuori, Mauro, additional, Cosola, Davide, additional, Corleone, Pio, additional, Lazzari, Giovanni, additional, Franceschi, Angelo, additional, Calcagno, Pietro, additional, Salvador, Luca, additional, Manzoni, Alberto, additional, Pennacchi, Luca, additional, Libia, Annarita, additional, Notte, Francesca, additional, Bernasconi, Davide P., additional, Mori, Silvia, additional, and Gaudesi, Davide, additional

Published
2022
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26. Early versus Late initiation of direct oral Anticoagulants in post-ischaemic stroke patients with atrial fibrillatioN (ELAN): Protocol for an international, multicentre, randomised-controlled, two-arm, open, assessor-blinded trial

Author

Fischer, Urs, primary, Trelle, Sven, additional, Branca, Mattia, additional, Salanti, Georgia, additional, Paciaroni, Maurizio, additional, Ferrari, Cecilia, additional, Abend, Stefanie, additional, Beyeler, Seraina, additional, Strbian, Daniel, additional, Thomalla, Götz, additional, Ntaios, George, additional, Bonati, Leo H, additional, Michel, Patrik, additional, Nedeltchev, Krassen, additional, Gattringer, Thomas, additional, Sandset, Else Charlotte, additional, Kelly, Peter, additional, Lemmens, Robin, additional, Koga, Masatoshi, additional, Sylaja, Padmavathy N, additional, de Sousa, Diana Aguiar, additional, Bornstein, Natan M, additional, Gdovinova, Zuzana, additional, Seiffge, David J, additional, Gralla, Jan, additional, Horvath, Thomas, additional, and Dawson, Jesse, additional

Published
2022
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29. A cross‐cultural qualitative study of the ethical aspects in the transition from child mental health services to adult mental health services

Author

O'Hara, Lesley, Holme, Ingrid, Tah, Priya, Franić, Tomislav, Vrljičak Davidović, Nikolina, Paul, Moli, Singh, Swaran Preet, Street, Cathy, Tuomainen, Helena, Schulze, Ulrike, McNicholas, Fiona, Madan, Jason, Wolke, Dieter, Warwick, Jane, Canaway, Alastair, Griffin, James, Appleton, Rebecca, Tuffrey, Amanda, Wilson, Anna, Gatherer, Charlotte, Walker, Leanne, Girolamo, Giovanni, Signorini, Giulia, Ferrari, Alessandro, Gheza, Elisa, Ferrari, Cecilia, Rivolta, Laura, Levi, Flavia, Cataldo, Maria, Manenti, Lidia, Morini, Giorgia, Pastore, Adriana, Toselli, Cecilia, Varvara, Pamela, Santosh, Paramala, Sagar‐Ouriaghli, Ilyas, Heaney, Natalie, Singh, Jatinder, Purper‐ Ouakil, Diane, Russet, Frédérick, Maurice, Virginie, Humbertclaude, Véronique, Maras, Athanasios, Bodegom, Larissa, Overbeek, Mathilde, Fegert, Jörg M., Plener, Paul, Saam, Melanie, Breuninger, Ulrike, Schepker, Renate, Noterdaeme, Michele, Tremmery, Sabine, Hendrickx, Gaëlle, Gronostaj, Aleksandra, McKenna, Rachael, Lievesley, Kate, Fiori, Federico, Verhulst, Frank, Dieleman, Gwen C, Gerritsen, Suzanne, Wohner, Andrea, The MILESTONE Consortium, Child and Adolescent Psychiatry / Psychology, and Clinical Child and Family Studies

Subjects
Male, Child Health Services, Paternalism, 0302 clinical medicine, Health care, Child, media_common, 05 social sciences, Middle Aged, Justice and Strong Institutions, Psychiatry and Mental health, Transition, Female, Psychology, Autonomy, 050104 developmental & child psychology, Adult, Cross-Cultural Comparison, Mental Health Services, Transition to Adult Care, SDG 16 - Peace, Adolescent, Croatia, media_common.quotation_subject, Clinical Decision-Making, education, Stigma (botany), child and adolescent mental health services, adult mental health services, decision-making, qualitative research, ethics, Young Adult, 03 medical and health sciences, Nursing, SDG 3 - Good Health and Well-being, Humans, Cross-cultural, 0501 psychology and cognitive sciences, business.industry, SDG 16 - Peace, Justice and Strong Institutions, Mental health, Focus group, United Kingdom, 030227 psychiatry, Pediatrics, Perinatology and Child Health, business, Ireland, Qualitative research
Abstract

Background: Transitioning from Child and Adolescent Mental Health Services (CAMHS) to Adult Mental Health Services (AMHS) raises novel ethical aspects for healthcare professionals, as well as for young people, their parents and carers. Method: Focus groups were conducted in Croatia, Ireland and the United Kingdom with youth mental health groups and youth representatives with no mental health (MH) remit. One hundred and eleven participants, aged from 16 to 60 years, contributed to discussions. Results: Perpetuation of stigma, autonomy and decision-making were central themes as both enablers and deterrents of successful transition. The tension between professional (and at times parental) paternalism and young persons' growing autonomy was well captured in the themes; (a) desired practice, (b) who should decide, (c) the process of decision-making and (d) potential harm(s). Conclusions: This study provides insight into the ethical values, particularly autonomy and collaboratively working, which people expect to underpin the transition between CAMHS and AMHS. Key Practitioner Message: Engaging young people early in making decisions about their future care can enhance trust between practitioner and the young person. In addition to diagnosis, a number of factors (such as moving home; waiting lists and stigma) may need to be taken into account when considering the direction of future health care. When possible, alternatives to AMHS should be considered if considered by the young person to be a less-stigmatising treatment option.

Published
2020

30. Cohort profile: demographic and clinical characteristics of the MILESTONE longitudinal cohort of young people approaching the upper age limit of their child mental health care service in Europe

Author

Gerritsen, Suzanne E, primary, Maras, Athanasios, additional, van Bodegom, Larissa S, additional, Overbeek, Mathilde M, additional, Verhulst, Frank C, additional, Wolke, Dieter, additional, Appleton, Rebecca, additional, Bertani, Angelo, additional, Cataldo, Maria G, additional, Conti, Patrizia, additional, Da Fonseca, David, additional, Davidović, Nikolina, additional, Dodig-Ćurković, Katarina, additional, Ferrari, Cecilia, additional, Fiori, Federico, additional, Franić, Tomislav, additional, Gatherer, Charlotte, additional, De Girolamo, Giovanni, additional, Heaney, Natalie, additional, Hendrickx, Gaëlle, additional, Kolozsvari, Alfred, additional, Levi, Flavia Micol, additional, Lievesley, Kate, additional, Madan, Jason, additional, Martinelli, Ottaviano, additional, Mastroianni, Mathilde, additional, Maurice, Virginie, additional, McNicholas, Fiona, additional, O'Hara, Lesley, additional, Paul, Moli, additional, Purper-Ouakil, Diane, additional, de Roeck, Veronique, additional, Russet, Frédérick, additional, Saam, Melanie C, additional, Sagar-Ouriaghli, Ilyas, additional, Santosh, Paramala J, additional, Sartor, Anne, additional, Schandrin, Aurélie, additional, Schulze, Ulrike M E, additional, Signorini, Giulia, additional, Singh, Swaran P, additional, Singh, Jatinder, additional, Street, Cathy, additional, Tah, Priya, additional, Tanase, Elena, additional, Tremmery, Sabine, additional, Tuffrey, Amanda, additional, Tuomainen, Helena, additional, van Amelsvoort, Therese A M J, additional, Wilson, Anna, additional, Walker, Leanne, additional, and Dieleman, Gwen C, additional

Published
2021
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31. Effect of managed transition on mental health outcomes for young people at the child–adult mental health service boundary : a randomised clinical trial

Author

Singh, S. P., Tuomainen, H., Bouliotis, G., Canaway, A., De Girolamo, G., Dieleman, G. C., Franić, T., Madan, J., Maras, A., McNicholas, F., Paul, M., Purper-Ouakil, D., Santosh, P., Schulze, U. M.E., Street, C., Tremmery, S., Verhulst, F. C., Wells, P., Wolke, D., Warwick, J., Tah, Priya, Griffin, James, Appleton, Rebecca, Heaney, Natalie, Lievesley, Kate, Mastroianni, Mathilde, Singh, Jatinder, Adams, Laura, Signorini, Giulia, Ferrari, Alessandro, Gheza, Elisa, Ferrari, Cecilia, Rivolta, Laura, Levi, Flavia, Cataldo, Maria, Manenti, Lidia, Morini, Giorgia, Pastore, Adriana, Stagni, Pamela, Toselli, Cecilia, Varvara, Pamela, Russet, Frédérick, Maurice, Virginie, Humbertclaude, Véronique, Bodegom, Larissa S.Van, Overbeek, Mathilde M., Gerritsen, Suzanne E., Saam, Melanie, Breuninger, Ulrike, Hendrickx, Gaëlle, The MILESTONE Consortium, and Child and Adolescent Psychiatry / Psychology

Subjects
Clinical trial, Psychiatry and Mental health, medicine.medical_specialty, SDG 3 - Good Health and Well-being, RJ, medicine, Psychiatry, Psychology, Mental health, Applied Psychology, Boundary (real estate), Mental health service
Abstract

BackgroundPoor transition planning contributes to discontinuity of care at the child–adult mental health service boundary (SB), adversely affecting mental health outcomes in young people (YP). The aim of the study was to determine whether managed transition (MT) improves mental health outcomes of YP reaching the child/adolescent mental health service (CAMHS) boundary compared with usual care (UC).MethodsA two-arm cluster-randomised trial (ISRCTN83240263 and NCT03013595) with clusters allocated 1:2 between MT and UC. Recruitment took place in 40 CAMHS (eight European countries) between October 2015 and December 2016. Eligible participants were CAMHS service users who were receiving treatment or had a diagnosed mental disorder, had an IQ ⩾ 70 and were within 1 year of reaching the SB. MT was a multi-component intervention that included CAMHS training, systematic identification of YP approaching SB, a structured assessment (Transition Readiness and Appropriateness Measure) and sharing of information between CAMHS and adult mental health services. The primary outcome was HoNOSCA (Health of the Nation Outcome Scale for Children and Adolescents) score 15-months post-entry to the trial.ResultsThe mean difference in HoNOSCA scores between the MT and UC arms at 15 months was −1.11 points (95% confidence interval −2.07 to −0.14, p = 0.03). The cost of delivering the intervention was relatively modest (€17–€65 per service user).ConclusionsMT led to improved mental health of YP after the SB but the magnitude of the effect was small. The intervention can be implemented at low cost and form part of planned and purposeful transitional care.

Published
2021

32. Machine Learning Predictive Model to Guide Treatment Allocation for Recurrent Hepatocellular Carcinoma After Surgery.

Author

Famularo, Simone, Donadon, Matteo, Cipriani, Federica, Fazio, Federico, Ardito, Francesco, Iaria, Maurizio, Perri, Pasquale, Conci, Simone, Dominioni, Tommaso, Lai, Quirino, La Barba, Giuliano, Patauner, Stefan, Molfino, Sarah, Germani, Paola, Zimmitti, Giuseppe, Pinotti, Enrico, Zanello, Matteo, Fumagalli, Luca, Ferrari, Cecilia, and Romano, Maurizio

Published
2023
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33. The Impact of Postoperative Ascites on Survival After Surgery for Hepatocellular Carcinoma: a National Study

Author

Famularo, Simone, primary, Donadon, Matteo, additional, Cipriani, Federica, additional, Ardito, Francesco, additional, Iaria, Maurizio, additional, Carissimi, Francesca, additional, Perri, Pasquale, additional, Dominioni, Tommaso, additional, Zanello, Matteo, additional, Conci, Simone, additional, Molfino, Sarah, additional, D’Acapito, Fabrizio, additional, Germani, Paola, additional, Ferrari, Cecilia, additional, Patauner, Stefan, additional, Pinotti, Enrico, additional, Sciannamea, Ivano, additional, Garatti, Marco, additional, Lodo, Enrico, additional, Troci, Albert, additional, Delvecchio, Antonella, additional, Floridi, Antonio, additional, Bernasconi, Davide Paolo, additional, Fumagalli, Luca, additional, Chiarelli, Marco, additional, Memeo, Riccardo, additional, Crespi, Michele, additional, Zanus, Giacomo, additional, Zimmitti, Giuseppe, additional, Antonucci, Adelmo, additional, Zago, Mauro, additional, Frena, Antonio, additional, Griseri, Guido, additional, Tarchi, Paola, additional, Ercolani, Giorgio, additional, Baiocchi, Gian Luca, additional, Ruzzenente, Andrea, additional, Jovine, Elio, additional, Maestri, Marcello, additional, Grazi, GianLuca, additional, Valle, Raffaele Dalla, additional, Giuliante, Felice, additional, Aldrighetti, Luca, additional, Romano, Fabrizio, additional, Torzilli, Guido, additional, Costa, Guido, additional, Ciulli, Cristina, additional, Giani, Alessandro, additional, Ratti, Francesca, additional, Bellobono, Manuela, additional, Cremaschi, Elena, additional, Valsecchi, Maria Grazia, additional, De Peppo, Valerio, additional, Calabrese, Francesco, additional, DeSario, Giuseppina, additional, Lazzari, Giovanni, additional, Cucchetti, Alessandro, additional, Cosola, Davide, additional, Percivale, Andrea, additional, Ciola, Michele, additional, Montuori, Mauro, additional, Frassani, Silvia, additional, Manzoni, Alberto, additional, Salvador, Luca, additional, Pennacchi, Luca, additional, Corleone, Pio, additional, and Conticchio, Maria, additional

Published
2021
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35. Curative versus palliative treatments for recurrent hepatocellular carcinoma: a multicentric weighted comparison

Author

Famularo, Simone, primary, Donadon, Matteo, additional, Cipriani, Federica, additional, Bernasconi, Davide P., additional, LaBarba, Giuliano, additional, Dominioni, Tommaso, additional, Iaria, Maurizio, additional, Molfino, Sarah, additional, Conci, Simone, additional, Ferrari, Cecilia, additional, Garatti, Marco, additional, Delvecchio, Antonella, additional, Troci, Albert, additional, Patauner, Stefan, additional, Frassani, Silvia, additional, Cosimelli, Maurizio, additional, Zanus, Giacomo, additional, Giuliante, Felice, additional, Jovine, Elio, additional, Valsecchi, Maria G., additional, Grazi, GianLuca, additional, Antonucci, Adelmo, additional, Frena, Antonio, additional, Crespi, Michele, additional, Memeo, Riccardo, additional, Zimmitti, Giuseppe, additional, Griseri, Guido, additional, Ruzzenente, Andrea, additional, Baiocchi, Gianluca, additional, DallaValle, Raffaele, additional, Maestri, Marcello, additional, Ercolani, Giorgio, additional, Aldrighetti, Luca, additional, Torzilli, Guido, additional, Romano, Fabrizio, additional, Ciulli, Cristina, additional, Giani, Alessandro, additional, Carissimi, Francesca, additional, Costa, Guido, additional, Ratti, Francesca, additional, Cucchetti, Alessandro, additional, Calabrese, Francesco, additional, Cremaschi, Elena, additional, Lazzari, Giovanni, additional, Franceschi, Angelo, additional, Sega, Valentina, additional, Conticchio, Maria, additional, Pennacchi, Luca, additional, Ciola, Michele, additional, Sciannamea, Ivano, additional, and De Peppo, Valerio, additional

Published
2021
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36. Cohort profile:Demographic and clinical characteristics of the MILESTONE longitudinal cohort of young people approaching the upper age limit of their child mental health care service in Europe

Author

Gerritsen, Suzanne E., Maras, Athanasios, Van Bodegom, Larissa S., Overbeek, Mathilde M., Verhulst, Frank C., Wolke, Dieter, Appleton, Rebecca, Bertani, Angelo, Cataldo, Maria G., Conti, Patrizia, Da Fonseca, David, Davidović, Nikolina, Dodig-A †urković, Katarina, Ferrari, Cecilia, Fiori, Federico, Franić, Tomislav, Gatherer, Charlotte, De Girolamo, Giovanni, Heaney, Natalie, Hendrickx, Gaëlle, Kolozsvari, Alfred, Levi, Flavia Micol, Lievesley, Kate, Madan, Jason, Martinelli, Ottaviano, Mastroianni, Mathilde, Maurice, Virginie, McNicholas, Fiona, O'Hara, Lesley, Paul, Moli, Purper-Ouakil, Diane, De Roeck, Veronique, Russet, Frédérick, Saam, Melanie C., Sagar-Ouriaghli, Ilyas, Santosh, Paramala J., Sartor, Anne, Schandrin, Aurélie, Schulze, Ulrike M.E., Signorini, Giulia, Singh, Swaran P., Singh, Jatinder, Street, Cathy, Tah, Priya, Tanase, Elena, Tremmery, Sabine, Tuffrey, Amanda, Tuomainen, Helena, Van Amelsvoort, Therese A.M.J., Wilson, Anna, Walker, Leanne, Dieleman, Gwen C., Gerritsen, Suzanne E., Maras, Athanasios, Van Bodegom, Larissa S., Overbeek, Mathilde M., Verhulst, Frank C., Wolke, Dieter, Appleton, Rebecca, Bertani, Angelo, Cataldo, Maria G., Conti, Patrizia, Da Fonseca, David, Davidović, Nikolina, Dodig-A †urković, Katarina, Ferrari, Cecilia, Fiori, Federico, Franić, Tomislav, Gatherer, Charlotte, De Girolamo, Giovanni, Heaney, Natalie, Hendrickx, Gaëlle, Kolozsvari, Alfred, Levi, Flavia Micol, Lievesley, Kate, Madan, Jason, Martinelli, Ottaviano, Mastroianni, Mathilde, Maurice, Virginie, McNicholas, Fiona, O'Hara, Lesley, Paul, Moli, Purper-Ouakil, Diane, De Roeck, Veronique, Russet, Frédérick, Saam, Melanie C., Sagar-Ouriaghli, Ilyas, Santosh, Paramala J., Sartor, Anne, Schandrin, Aurélie, Schulze, Ulrike M.E., Signorini, Giulia, Singh, Swaran P., Singh, Jatinder, Street, Cathy, Tah, Priya, Tanase, Elena, Tremmery, Sabine, Tuffrey, Amanda, Tuomainen, Helena, Van Amelsvoort, Therese A.M.J., Wilson, Anna, Walker, Leanne, and Dieleman, Gwen C.

Abstract

Purpose The presence of distinct child and adolescent mental health services (CAMHS) and adult mental health services (AMHS) impacts continuity of mental health treatment for young people. However, we do not know the extent of discontinuity of care in Europe nor the effects of discontinuity on the mental health of young people. Current research is limited, as the majority of existing studies are retrospective, based on small samples or used non-standardised information from medical records. The MILESTONE prospective cohort study aims to examine associations between service use, mental health and other outcomes over 24 months, using information from self, parent and clinician reports. Participants Seven hundred sixty-three young people from 39 CAMHS in 8 European countries, their parents and CAMHS clinicians who completed interviews and online questionnaires and were followed up for 2 years after reaching the upper age limit of the CAMHS they receive treatment at. Findings to date This cohort profile describes the baseline characteristics of the MILESTONE cohort. The mental health of young people reaching the upper age limit of their CAMHS varied greatly in type and severity: 32.8% of young people reported clinical levels of self-reported problems and 18.6% were rated to be € markedly ill', € severely ill' or € among the most extremely ill' by their clinician. Fifty-seven per cent of young people reported psychotropic medication use in the previous half year. Future plans Analysis of longitudinal data from the MILESTONE cohort will be used to assess relationships between the demographic and clinical characteristics of young people reaching the upper age limit of their CAMHS and the type of care the young person uses over the next 2 years, such as whether the young person transitions to AMHS. At 2 years follow-up, the mental health outcomes of young people following different care pathways will be compared. Trial registration number NCT03013595.

Published
2021

39. The Role of Subthreshold Micropulse Yellow Laser as an Alternative Option for the Treatment of Refractory Postoperative Cystoid Macular Edema

Author

Verdina, Tommaso, D'Aloisio, Rossella, Lazzerini, Andrea, Ferrari, Cecilia, Valerio, Edoardo, Mastropasqua, Rodolfo, and Cavallini, Gian Maria

Subjects
post-surgical cystoid macular edema, genetic structures, lcsh:R, micropulse yellow laser, lcsh:Medicine, sense organs, cataract surgery, refractory macular edema, Article, eye diseases
Abstract

Background: To evaluate the efficacy and the safety of subthreshold micropulse yellow laser (SMYL) in the treatment of chronic postoperative cystoid macular edema (PCME), which is refractory to standard therapies. Methods: A retrospective chart review of ten eyes of ten patients affected by refractory PCME who underwent SMYL was performed. Five PCME cases were subsequent to uncomplicated cataract surgery (CS), two cases to complicated CS (CCS) with posterior capsule rupture and three cases occurred after retinal detachment surgery (RD). All conditions were refractory to conventional treatments prior to SMYL interventions for at least 4 months, including nonsteroidal anti-inflammatory eyedrops, topical steroids, oral indomethacin, sub-Tenon’s triamcinolone injections and Dexamethasone intravitreal implants. All patients underwent one or more treatments with 577 nm SMYL photo-stimulation, with 7 × 7 grids with confluent spots and a 5% duty cycle covering the whole edematous retina, including the foveal center. Best corrected visual acuity (BCVA) and central macular thickness (CMT) were obtained using OCT, and evaluated before and after the treatment at 1, 2, 3 and 6-month follow-ups. Results: A complete subfoveal macular edema resolution was observed in all of the eyes, with statistically significant improvements in terms of BCVA and CMT in all of the follow-up timelines (at 6 months, p = 0.002 and p = 0.005, respectively). The mean number of laser treatments was 1.3. At the final follow-up, a complete subfoveal edema reabsorption was observed in all patients with visual acuity improvement. No complications were observed in any case. Conclusions: SMYL seems to be a safe and effective treatment for the long-term resolution of refractory PCME and may be a useful alternative to expensive and invasive therapeutic options.

Published
2020

40. Performance of Comprehensive Complication Index and Clavien-Dindo Complication Scoring System in Liver Surgery for Hepatocellular Carcinoma

Author

Giani, Alessandro, primary, Cipriani, Federica, additional, Famularo, Simone, additional, Donadon, Matteo, additional, Bernasconi, Davide Paolo, additional, Ardito, Francesco, additional, Fazio, Federico, additional, Nicolini, Daniele, additional, Perri, Pasquale, additional, Giuffrida, Mario, additional, Pontarolo, Nicholas, additional, Zanello, Matteo, additional, Lai, Quirino, additional, Conci, Simone, additional, Molfino, Sarah, additional, Germani, Paola, additional, Pinotti, Enrico, additional, Romano, Maurizio, additional, La Barba, Giuliano, additional, Ferrari, Cecilia, additional, Patauner, Stefan, additional, Manzoni, Alberto, additional, Sciannamea, Ivano, additional, Fumagalli, Luca, additional, Troci, Albert, additional, Ferraro, Valentina, additional, Floridi, Antonio, additional, Romano, Fabrizio, additional, Ciulli, Cristina, additional, Braga, Marco, additional, Ratti, Francesca, additional, Costa, Guido, additional, Razionale, Francesco, additional, Russolillo, Nadia, additional, Marinelli, Laura, additional, De Peppo, Valerio, additional, Cremaschi, Elena, additional, Calabrese, Francesco, additional, Larghi Laureiro, Zoe, additional, Lazzari, Giovanni, additional, Cosola, Davide, additional, Montuori, Mauro, additional, Salvador, Luca, additional, Cucchetti, Alessandro, additional, Franceschi, Angelo, additional, Ciola, Michele, additional, Sega, Valentina, additional, Calcagno, Pietro, additional, Pennacchi, Luca, additional, Tedeschi, Michele, additional, Memeo, Riccardo, additional, Crespi, Michele, additional, Chiarelli, Marco, additional, Antonucci, Adelmo, additional, Zimmitti, Giuseppe, additional, Frena, Antonio, additional, Percivale, Andrea, additional, Ercolani, Giorgio, additional, Zanus, Giacomo, additional, Zago, Mauro, additional, Tarchi, Paola, additional, Baiocchi, Gian Luca, additional, Ruzzenente, Andrea, additional, Rossi, Massimo, additional, Jovine, Elio, additional, Maestri, Marcello, additional, Dalla Valle, Raffaele, additional, Grazi, Gian Luca, additional, Vivarelli, Marco, additional, Ferrero, Alessandro, additional, Giuliante, Felice, additional, Torzilli, Guido, additional, Aldrighetti, Luca, additional, and Gianotti, Luca, additional

Published
2020
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41. Biliary Tree Cysts and Surgical Treatment: Outcomes in a Multicentric Study.

Author

Ferrari, Cecilia, Blanco Rodríguez, Manuel, Molina, Víctor, Martín, Belén, Espinet, Marina, Percivale, Andrea, Griseri, Guido, Moral, Antonio, and Sánchez-Cabús, Santiago

Subjects
*BILIARY tract, *CHOLANGITIS, *CHOLANGIOGRAPHY, *TREATMENT effectiveness, *CYSTS (Pathology), *ABDOMINAL pain, *RESEARCH, *BILE duct abnormalities, *RETROSPECTIVE studies, *EVALUATION research, *COMPARATIVE studies, *BILE ducts, *HEPATECTOMY, *DISEASE complications, WESTERN countries, BILE duct tumors
Abstract

Background: Biliary tree cysts (BTCs) represent an either localized or multifocal abnormal dilatation of the biliary tree, which entails an increased risk of acute cholangitis and cholangiocarcinoma (2.5%-16%). Its incidence in Western countries is ∼1/100.000-1/150.000, being more frequent in Asia (1/1.000). These cysts are usually classified according to Todani classification, which is based on site and morphology of cysts. Patients and Methods: This is a retrospective multicentric descriptive study of patients surgically treated for BTCs. From 2005 to 2018, 25 cases were collected between Hospital de la Santa Creu i Sant Pau (Barcelona, Spain) and Ospedale San Paolo (Savona, Italy). Clinical presentation was characterized by abdominal pain, jaundice, fever, and sometimes weight loss. Eight patients presented Todani type I, 1 patient Todani type II, 3 patients Todani III, 1 patient Todani type IV, and 12 patients Todani type V. Results: Among the 25 surgically treated patients, 12 patients underwent liver resection, 7 patients underwent resection of the extrahepatic biliary tree, 3 patients underwent BTC removal through a duodenotomy, 1 patient underwent resection of the extrahepatic biliary tree and liver resection, and 2 patients underwent pancreatoduodenectomy. Overall 30-day morbidity rate was 20%, and 90-day mortality was 0%. Pathologic examination confirmed diagnosis of cholangiocarcinoma in 5 patients (20%). After a median follow-up of 59 months, 20 patients are alive and in good conditions, whereas 50% of patients with cholangiocarcinoma died for disease progression. Conclusions: Surgical treatment for BTCs is associated with acceptable postoperative outcomes, with moderate morbidity and null mortality rates. Moreover, the risk of developing cholangiocarcinoma is still high that prompts surgical treatment once diagnosis is made. [ABSTRACT FROM AUTHOR]

Published
2022
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42. Single Large Hepatocellular Carcinoma > 5 cm with Surgical Indication: Is it Mandatory a Major Hepatectomy? A Propensity-score Weighted Analysis

Author

Romano, Fabrizio, Donadon, Matteo, Cipriani, Federica, Serenari, Matteo, Ardito, Francesco, Lauterio, Andrea, Vitale, Alessandro, Fazio, Federico, Nicolini, Daniele, Perri, Pasquale, Iaria, Giuseppe, Famularo, Simone, Dominioni, Tommaso, Zanello, Matteo, Lai, Quirino, Conci, Simone, Molfino, Sarah, Ferrari, Cecilia, Germani, Paola, Scotti, Mauro Alessandro, Zago, Mauro, Zimmitti, Giuseppe, La Barba Maurizio Romano, Giuliano, Sciannamea, Ivano, Fumagalli, Luca, Troci, Albert, Ferraro, Valentina, Memeo, Riccardo, Crespi, Michele, Chiarelli, Marco, Antonucci, Adelmo, Zanus, Giacomo, Ercolani, Giorgio, Hilal, Moh’d Abu, Pinotti, Enrico, Tarchi, Paola, Griseri, Guido, Baiocchi, Gian Luca, Ruzzenente, Andrea, Rossi, Massimo, Jovine, Elio, Maestri, Marcello, Garancini, M., Ferrero, A., De Carlis, L., Grazi, G.L., Giuliante, F., Cillo, U., Cescon, M., Valle, R. Dalla, Vivarelli, M., Torzilli, G., and Aldrighetti, L.

Published
2023
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46. Factors Affecting Local and Intra Hepatic Distant Recurrence After Surgery for Hcc: An Alternative Perspective on Microvascular Invasion and Satellitosis – A Western European Multicentre Study

Author

Famularo, Simone, primary, Piardi, Tullio, additional, Molfino, Sarah, additional, Di Martino, Marcello, additional, Ferrari, Cecilia, additional, Ielpo, Benedetto, additional, Diago, Maria Victoria, additional, Giani, Alessandro, additional, Griseri, Guido, additional, Terés, Lara Bianco, additional, Gianotti, Luca, additional, Baiocchi, Gian Luca, additional, Sommacale, Daniele, additional, and Romano, Fabrizio, additional

Published
2020
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47. Long-Lived Particle Reconstruction at CLIC

Author

Ferrari, Cecilia

Subjects
High Energy Physics::Experiment, Particle Physics - Experiment
Abstract

Several Beyond Standard Model theories predict the existence of particles whose lifetime is at the millimeter scale. If generated in a high energy collider, these particles could live long enough to travel in the detector tracking system for a few centimeters. Before decaying, they could leave several detectable hits, that can be clustered by the algorithms into a stub track. Hence, the search of long-lived particles (LLPs) is very well-motivated in high energy colliders with high-resolution tracking detectors and robust reconstruction algorithms. The proposed future e+ e− linear collider CLIC provides the perfect environment for the search of these particles, thanks to the lack of QCD-background and its detector low material budget. The presented work tested the CLIC third stage (√s = 3 TeV) reconstruction performances, analyzing simulated stub tracks originating from LLP pair production. In particular, the particles involved were charginos with lifetime cτ ≈600 mm and mass m≈1.5 TeV. LLP tracks were found to be reconstructable in more than 90% of the cases in the detector central region.

Published
2019

49. Supervivencia de las laptops XO: ¿las características sociodemográficas de los alumnos inciden en la igualdad de acceso?

Author

Marconi Ferrari, Cecilia and Goyeneche, Juan José

Subjects
Plan Ceibal, Supervivencia, Sociodemographic characteristics, LAPTOP, Survival, laptops XO, ENSEÑANZA PUBLICA, Características sociodemográficas, DEMOGRAFÍA, TECNOLOGIA DE LA INFORMACION, COMPUTADORAS, Event analysis, ENSEÑANZA PRIMARIA, Mortalidad, Análisis de eventos, Uruguay, Mortality, CONDICIONES SOCIALES
Abstract

El presente trabajo tiene por objetivo estudiar la incidencia de las características sociodemográficas de los alumnos de Educación Primaria Pública de Uruguay en la supervivencia de las laptops XO de Plan Ceibal. El estudio sobre la sostenibilidad del acceso a la tecnología en el tiempo resulta de gran interés en tanto determina las condiciones de continuidad en el acceso a la información y a los recursos educativos digitales. La implementación de Plan Ceibal en 2007 ha tenido un fuerte impacto en la disminución de la brecha digital en términos de acceso. Asimismo, ha puesto a disposición de la comunidad educativa un gran número de herramientas educativas digitales que tienen como finalidad apoyar los procesos de aprendizaje y contribuir a la generación de capacidades de los alumnos promoviendo una educación de calidad. La sostenibilidad del parque de laptops y el acceso a las tecnologías de la información y comunicación es una de las tareas fundamentales para que todos los alumnos del sistema educativo público puedan acceder en cualquier momento y lugar a los diferentes recursos. En ese sentido, con la finalidad de promover la equidad e igualdad de oportunidades es que la investigación se propone analizar las funciones de supervivencia de los equipos de los diferentes perfiles sociodemográficos de los alumnos de manera que se puedan tomar acciones en base a evidencia empírica. Con esos fines se utiliza la técnica de Análisis de Historia de Eventos para la obtención de las tasas de riesgo y se estiman las funciones de supervivencia de las laptops de la generación de alumnos que en 2010 ingresaron a Educación Primaria. A partir de la construcción de las tablas de vida se calculan las esperanzas de vida de las XO para los diferentes perfiles de alumnos. Las estimaciones realizadas reflejan que la vida útil de una XO aproximada por la esperanza de vida al momento de la entrega es de 1.084 días, lo que significa prácticamente 3 años, es decir 1 año antes de la fecha planificada de recambio por parte de Plan Ceibal. Además se observa que el contexto sociocultural, así como el género y el área geográfica de residencia del alumno son variables claves para determinar las tasas de riesgo a la rotura de los equipos. El perfil sociodemográfico del alumnado que presenta mayores tasas de riesgo a la rotura total de la laptop son los varones montevideanos de contextos socioculturales más desfavorables, con eventos de repetición de grado escolar en su trayectoria por Educación Primaria, y con registros previos de reparación en servicio técnico. Asimismo se identificó que la principal causa de rotura total de los equipos XO ha sido el teclado.

Published
2016

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