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3. Myosteatosis is closely associated with sarcopenia and significantly worse outcomes in patients with cirrhosis

Author

Iannone, Giulia, Serri, Paola, Bertino, Gaetano, Balsano, Clara, Iapadre, Nerio, Maida, Marcello, Sacerdoti, David, Natola, Leonardo Antonio, Ciacci, Carolina, Santonicola, Antonella, Cozzolongo, Raffaele, Surace, Lorenzo Antonio, Fracanzani, Anna Ludovica, Cespiati, Annalisa, Federico, Alessandro, Romeo, Mario, Grieco, Antonio, Marrone, Giuseppe, Vizioli, Luca, Di Cola, Simone, D’Amico, Gennaro, Caraceni, Paolo, Schepis, Filippo, Loredana, Simone, Lampertico, Pietro, Toniutto, Pierluigi, Martini, Silvia, Maimone, Sergio, Colecchia, Antonio, Svegliati Barone, Gianluca, Alessandria, Carlo, Aghemo, Alessio, Crocè, Saveria Lory, Adinolfi, Luigi Elio, Rendina, Maria, Lapenna, Lucia, Pompili, Enrico, Zaccherini, Giacomo, Saltini, Dario, Iavarone, Massimo, Tosetti, Giulia, Martelletti, Carolina, Nassisi, Veronica, Ferrarese, Alberto, Giovo, Ilaria, Masetti, Chiara, Pugliese, Nicola, Campigotto, Michele, Nevola, Riccardo, and Merli, Manuela

Published
2024
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4. A holistic evaluation of patients with chronic Hepatitis D virus (HDV) infection enrolled in the Italian PITER-B and delta cohort

Author

Aghemo, Alessio, Baiguera, Chiara, Battezzati, Pier Maria, Battistella, Sara, Bavetta, Maria Grazia, Bertoni, Costanza, Boni, Carolina, Brambilla, Paola, Bray, Antonella, Briano, Federica, Carmenini, Enrico, Castelli, Francesco, Cavalletto, Luisa, Cerini, Federica, Chidichimo, Luciana, Colella, Elisa, Cologni, Giuliana, Como, Silvia, Corsini, Romina, Costa, Chiara, Cotugno, Rosa, Cretella, Silvia, De Angelis, Fernando, De Leo, Pasqualina, Perri, Giovanni Di, Falbo, Elisabetta, Ferrigno, Luigina, Fornasiere, Ezio, Francisci, Daniela, Gatti, Pietro, Lampertico, Pietro, Lenci, Ilaria, Licata, Anna, Maida, Ivana, Marzano, Alfredo, Mastroianni, Antonio, Mazzaro, Cesare, Monti, Monica, Nardone, Gerardo, Nicolini, Laura Ambra, Passigato, Nicola, Pasticci, Maria Bruna, Pierotti, Piera, Pinchera, Biagio, Pollicino, Teresa, Porcu, Carmen, Quartini, Giulia, Rancatore, Gabriele, Romeo, Mario, Rumi, Maria Grazia, Saracino, Annalisa, Schioppa, Ornella, Serio, Ilaria, Soffredini, Roberta, Tata, Xhimi, Tizzani, Marco, Tonnini, Matteo, Torti, Carlo, Valenti, Daniela, Zaltron, Serena, Zoncada, Alessia, Kondili, Loreta A., Brancaccio, Giuseppina, Tosti, Maria Elena, Coco, Barbara, Quaranta, Maria Giovanna, Messina, Vincenzo, Ciancio, Alessia, Morisco, Filomena, Cossiga, Valentina, Claar, Ernesto, Rosato, Valerio, Ciarallo, Marianna, Cacciola, Irene, Ponziani, Francesca Romana, Cerrito, Lucia, Coppola, Roberta, Longobardi, Francesco, Biliotti, Elisa, Rianda, Alessia, Barbaro, Francesco, Coppola, Nicola, Stanzione, Maria, Barchiesi, Francesco, Fagiuoli, Stefano, Viganò, Mauro, Massari, Marco, Russo, Francesco Paolo, Ferrarese, Alberto, Laccabue, Diletta, Di Marco, Vito, Blanc, Pierluigi, Marrone, Aldo, Morsica, Giulia, Federico, Alessandro, Ieluzzi, Donatella, Rocco, Alba, Foschi, Francesco Giuseppe, Soria, Alessandro, Chessa, Luchino, Milella, Michele, Rosselli Del Turco, Elena, Madonia, Salvatore, Chemello, Liliana, Gentile, Ivan, Toniutto, Pierluigi, Bassetti, Matteo, Surace, Lorenzo, Baiocchi, Leonardo, Pellicelli, Adriano, De Santis, Adriano, Puoti, Massimo, Degasperi, Elisabetta, Niro, Grazia Anna, Zignego, Anna Linda, Craxi, Antonio, Raimondo, Giovanni, Santantonio, Teresa Antonia, Brunetto, Maurizia Rossana, and Gaeta, Giovanni Battista

Published
2024
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5. Trends in liver transplantation for primary sclerosing cholangitis

Author

Viganò, Raffaella, Fornasiere, Ezio, Catanzaro, Elisa, Marrone, Giuseppe, Milana, Martina, Calleri, Alberto, Scorzoni, Chiara, Frassanito, Gabriella, Lionetti, Raffaella, Dibenedetto, Clara, Morelli, Maria Cristina, Gambato, Martina, Martini, Silvia, Carrai, Paola, Toniutto, Pierluigi, Giannelli, Valerio, Donato, Francesca, Lenci, Ilaria, Pasulo, Luisa, Mazzarelli, Chiara, Ferrarese, Alberto, Rendina, Maria, Grieco, Antonio, Lanza, Alfonso Galeota, Baroni, Gianluca Svegliati, De Maria, Nicola, Marenco, Simona, Mameli, Laura, Ponziani, Francesca Romana, Vitale, Giovanni, and Burra, Patrizia

Published
2024
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6. Evolution of liver fibrosis in diabetic patients with NAFLD in a follow-up study: Hepatoprotective effects of sodium-glucose co-transporter-2 inhibitors

Author

Lombardi, Rosa, Mantovani, Alessandro, Cespiati, Annalisa, Francione, Paolo, Maffi, Gabriele, Del Zanna, Elena, Maffeis, Claudio, Colecchia, Antonio, Passigato, Nicola, Ferrarese, Alberto, Cusumanu, Caterina Daniela, Villani, Rosanna, Orsi, Emanuela, Grancini, Valeria, Airaghi, Lorena, Bignamini, Daniela, Serviddio, Gaetano, Targher, Giovanni, Dongiovanni, Paola, Fargion, Silvia, and Fracanzani, Anna Ludovica

Published
2024
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7. Predicting survival in patients with ‘non-high-risk’ acute variceal bleeding receiving β-blockers+ligation to prevent re-bleeding

Author

Balcar, Lorenz, Mandorfer, Mattias, Hernández-Gea, Virginia, Procopet, Bogdan, Meyer, Elias Laurin, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Samaniego, Luis Ibáñez, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Bureau, Christophe, Trebicka, Jonel, Herrera, Elba Llop, Laleman, Wim, Palazón Azorín, José María, Alonso, Jose Castellote, Gluud, Lise Lotte, Ferreira, Carlos Noronha, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Grønbæk, Henning, Hernandez Guerra, Manuel Nicolas, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan Gonzalez, Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Nevens, Frederik, Calleja, Jose Luis, Jansen, Christian, Catalina, María Vega, Albillos, Agustín, Rudler, Marika, Tapias, Edilmar Alvarado, Guardascione, Maria Anna, Tantau, Marcel, Schwarzer, Rémy, Reiberger, Thomas, Laursen, Stig Borbjerg, Lopez-Gomez, Marta, Cachero, Alba, Ferrarese, Alberto, Ripoll, Cristina, La Mura, Vincenzo, Bosch, Jaime, and García-Pagán, Juan Carlos

Published
2024
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8. Trends in chronic hepatitis B virus infection in Italy over a 10-year period: Clues from the nationwide PITER and MASTER cohorts toward elimination

Author

Pasulo, Luisa, Coppola, Carmine, Pisano, Federica, Romano, Mariarosaria, Porcu, Carmen, Bottalico, Irene Francesca, Cossiga, Valentina, Tata, Xhimi, Sagnelli, Caterina, Pierotti, Piera, Degasperi, Elisabetta, Rosato, Valerio, Badia, Lorenzo, Ieluzzi, Dontella, Monti, Monica, Bavetta, Maria Grazia, Cavalletto, Luisa, Toniutto, Pierluigi, Fornasiere, Ezio, Colecchia, Antonio, Ferrarese, Alberto, Nardone, Gerardo, Rocco, Alba, Viganò, Mauro, Foschi, Francesco Giuseppe, Conti, Fabio, Morsica, Giulia, Salpietro, Stefania, Torti, Carlo, Costa, Chiara, Federico, Alessandro, Dallio, Marcello, Giorgini, Alessia, Anselmo, Marco, De Leo, Pasqualina, Zaltron, Serena, Cambianica, Anna, Piscaglia, Fabio, Serio, Ilaria, Schivazappa, Simona, Mastroianni, Antonio, Chidichimo, Luciana, Massari, Marco, Mazzaro, Cesare, Marrone, Aldo, D'Amore, Francesca Maria, D'Offizi, Gianpiero, Licata, Anna, Niro, Grazia Anna, Pollicino, Teresa, Aghemo, Alessio, Brancaccio, Giuseppina, Coco, Barbara, Nardi, Alessandra, Quaranta, Maria Giovanna, Tosti, Maria Elena, Ferrigno, Luigina, Cacciola, Irene, Messina, Vincenzo, Chessa, Luchino, Morisco, Filomena, Milella, Michele, Barbaro, Francesco, Ciancio, Alessia, Russo, Francesco Paolo, Coppola, Nicola, Blanc, Pierluigi, Claar, Ernesto, Verucchi, Gabriella, Puoti, Massimo, Zignego, Anna Linda, Chemello, Liliana, Madonia, Salvatore, Fagiuoli, Stefano, Marzano, Alfredo, Ferrari, Carlo, Lampertico, Pietro, Di Marco, Vito, Craxì, Antonio, Santantonio, Teresa Antonia, Raimondo, Giovanni, Brunetto, Maurizia R., Gaeta, Giovanni Battista, and Kondili, Loreta A.

Published
2023
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11. Safe pregnancy after liver transplantation: Evidence from a multicenter Italian collaborative study

Author

Sciarrone, Salvatore Stefano, Ferrarese, Alberto, Bizzaro, Debora, Volpato, Sofia, Donato, Francesca Maria, Invernizzi, Federica, Trespidi, Laura, Ramezzana, Ilaria Giuditta, Avolio, Alfonso Wolfango, Nure, Erida, Pascale, Marco Maria, Fagiuoli, Stefano, Pasulo, Luisa, Merli, Manuela, Lapenna, Lucia, Toniutto, Pierluigi, Lenci, Ilaria, Di Donato, Roberto, De Maria, Nicola, Villa, Erica, Galeota Lanza, Alfonso, Marenco, Simona, Bhoori, Sherrie, Mameli, Laura, Cillo, Umberto, Boccagni, Patrizia, Russo, Francesco Paolo, Bo, Patrizio, Cosmi, Erich, and Burra, Patrizia

Published
2022
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12. Bacterial Infections in End-Stage Liver Disease: Implications for Liver Transplantation.

Author

Ferrarese, Alberto, Senzolo, Marco, Cattelan, Anna Maria, Sasset, Lolita, Battistella, Sara, Zanetto, Alberto, Germani, Giacomo, Russo, Francesco Paolo, Gambato, Martina, Pelizzaro, Filippo, Vio, Stefania, Bassi, Domenico, Cillo, Umberto, and Burra, Patrizia

Subjects
BACTERIAL disease risk factors, DIAGNOSIS of bacterial diseases, BACTERIAL disease treatment, CIRRHOSIS of the liver, BACTERIAL diseases, LIVER transplantation, LIVER failure, BIOMARKERS, DISEASE complications
Abstract

Bacterial infections are a common complication in patients with decompensated liver cirrhosis. The complex landscape of cirrhosis, characterized by immune paralysis and an exhausted response to exogenous triggers, explains the higher prevalence of such infections, particularly in advanced disease stages. In clinical practice, the onset of a bacterial infection can lead to further deterioration of hepatic and extra-hepatic function, potentially resulting in acute decompensation or acute-on-chronic liver failure. This has significant clinical implications, particularly for patients awaiting a transplant. In this review, we will discuss the latest evidence on the diagnosis and therapy of bacterial infections in patients with decompensated cirrhosis. Additionally, we will analyze the impact of bacterial infections in the context of liver transplantation, discussing debated topics such as the timing of transplantation in patients with infections, potential implications for prioritization, effects on post-operative recovery, grafts, and patient survival. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Frailty and sarcopenia in patients with cirrhosis awaiting liver transplantation: evidence from a single-centre, prospective cohort study.

Author

D'Arcangelo, Francesca, Zanetto, Alberto, Ferrarese, Alberto, Gambato, Martina, Lanari, Jacopo, Piano, Salvatore, Germani, Giacomo, Senzolo, Marco, Russo, Francesco Paolo, Angeli, Paolo, Cillo, Umberto, and Burra, Patrizia

Abstract

Sarcopenia and frailty are common complications in patients with cirrhosis evaluated for liver transplantation (LT). Although the negative impact of sarcopenia on patient's outcome has been well studied, the prognostic role of frailty is not as clear. We assessed the prevalence of sarcopenia and frailty and the clinical impact of frailty in a prospective cohort of cirrhosis patients with and without hepatocellular carcinoma (HCC) listed for LT. Patients with cirrhosis were prospectively recruited at the time of admission into the waiting list. Clinical and lab values were collected. Physical frailty was assessed by liver frailty index (LFI) and patients were categorized into robust (< 3.2); pre-frail (between 3.2 and 4.5), and frail (> 4.5). Skeletal muscle mass was evaluated via skeletal muscle index (SMI) obtained from last CT scan before LT; sarcopenia was defined by SMI < 50 cm2/m2 in males and < 39 cm2/m2 in females. 105 patients were included, of which 42 (40%) had hepatocellular carcinoma (HCC). In patients without HCC (63.5% males, median age 61 years), 36.5% were frail, 50.8% were pre-frail and 12.7% were robust. Frail patients were older than non-frail patients (63 vs. 56; p = 0.008) and had more severe liver disease (Child C: 65% vs. 37.5%; p = 0.02). Prevalence of sarcopenia in patients without HCC was 63%, with similar value of median SMI between frail and not frail patients (p = 0.454). Patients with HCC (78.6% males, 65 years old) were 21.4% frail, 61.9% pre-frail, and 16.7% robust. Frail patients had more severe liver disease (Child C: 77% vs. 18.2%; p = 0.004), whereas age was comparable to non-frail patients; among patients without HCC, during a median follow-up of 263 days, 17% died (of which 72% were frail) and 10 patients were delisted due to clinical improvement (none of whom were frail). Among those with HCC, during a median follow-up of 289 days, 4 (9%) patients died of which 50% were frail. Frailty and sarcopenia are common complications in patients with cirrhosis awaiting LT. Frailty appears to be associated with an increased risk of mortality during wait-list time especially in those with decompensated cirrhosis. At univariate analysis Meld score, Child score and presence of frailty were found to be associated with shorter survival, however, at multivariate analysis presence of frailty and Child C vs. A/B were the only independent predictor of death. Larger cohorts are required to confirm these results. [ABSTRACT FROM AUTHOR]

Published
2024
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15. A holistic evaluation of patients with chronic Hepatitis D virus (HDV) infection enrolled in the Italian PITER-B and Delta cohort

Author

Kondili, Loreta A., primary, Brancaccio, Giuseppina, additional, Tosti, Maria Elena, additional, Coco, Barbara, additional, Quaranta, Maria Giovanna, additional, Messina, Vincenzo, additional, Ciancio, Alessia, additional, Morisco, Filomena, additional, Cossiga, Valentina, additional, Claar, Ernesto, additional, Rosato, Valerio, additional, Ciarallo, Marianna, additional, Cacciola, Irene, additional, Ponziani, Francesca Romana, additional, Cerrito, Lucia, additional, Coppola, Roberta, additional, Longobardi, Francesco, additional, Biliotti, Elisa, additional, Rianda, Alessia, additional, Barbaro, Francesco, additional, Coppola, Nicola, additional, Stanzione, Maria, additional, Barchiesi, Francesco, additional, Fagiuoli, Stefano, additional, Viganò, Mauro, additional, Massari, Marco, additional, Russo, Francesco Paolo, additional, Ferrarese, Alberto, additional, Laccabue, Diletta, additional, Marco, Vito Di, additional, Blanc, Pierluigi, additional, Marrone, Aldo, additional, Morsica, Giulia, additional, Federico, Alessandro, additional, Ieluzzi, Donatella, additional, Rocco, Alba, additional, Foschi, Francesco Giuseppe, additional, Soria, Alessandro, additional, Maida, Ivana, additional, Chessa, Luchino, additional, Milella, Michele, additional, Turco, Elena Rosselli del, additional, Madonia, Salvatore, additional, Chemello, Liliana, additional, Gentile, Ivan, additional, Toniutto, Pierluigi, additional, Bassetti, Matteo, additional, Surace, Lorenzo, additional, Baiocchi, Leonardo, additional, Pellicelli, Adriano, additional, De Santis, Adriano, additional, Puoti, Massimo, additional, Degasperi, Elisabetta, additional, Niro, Grazia Anna, additional, Zignego, Anna Linda, additional, Craxi, Antonio, additional, Raimondo, Giovanni, additional, Santantonio, Teresa Antonia, additional, Brunetto, Maurizia Rossana, additional, Gaeta, Giovanni Battista, additional, and Investigators, on behalf of PITER Collaborating, additional

Published
2024
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16. Myosteatosis is closely associated with sarcopenia and significantly worse outcomes in patients with cirrhosis

Author

Di Cola, Simone, primary, D’Amico, Gennaro, additional, Caraceni, Paolo, additional, Schepis, Filippo, additional, Loredana, Simone, additional, Lampertico, Pietro, additional, Toniutto, Pierluigi, additional, Martini, Silvia, additional, Maimone, Sergio, additional, Colecchia, Antonio, additional, Svegliati Barone, Gianluca, additional, Alessandria, Carlo, additional, Aghemo, Alessio, additional, Crocè, Saveria Lory, additional, Adinolfi, Luigi Elio, additional, Rendina, Maria, additional, Lapenna, Lucia, additional, Pompili, Enrico, additional, Zaccherini, Giacomo, additional, Saltini, Dario, additional, Iavarone, Massimo, additional, Tosetti, Giulia, additional, Martelletti, Carolina, additional, Nassisi, Veronica, additional, Ferrarese, Alberto, additional, Giovo, Ilaria, additional, Masetti, Chiara, additional, Pugliese, Nicola, additional, Campigotto, Michele, additional, Nevola, Riccardo, additional, Merli, Manuela, additional, Iannone, Giulia, additional, Serri, Paola, additional, Bertino, Gaetano, additional, Balsano, Clara, additional, Iapadre, Nerio, additional, Maida, Marcello, additional, Sacerdoti, David, additional, Natola, Leonardo Antonio, additional, Ciacci, Carolina, additional, Santonicola, Antonella, additional, Cozzolongo, Raffaele, additional, Surace, Lorenzo Antonio, additional, Fracanzani, Anna Ludovica, additional, Cespiati, Annalisa, additional, Federico, Alessandro, additional, Romeo, Mario, additional, Grieco, Antonio, additional, Marrone, Giuseppe, additional, and Vizioli, Luca, additional

Published
2024
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17. Trends in liver transplantation for primary sclerosing cholangitis.

Author

Morelli, Maria Cristina, Gambato, Martina, Martini, Silvia, Carrai, Paola, Toniutto, Pierluigi, Giannelli, Valerio, Donato, Francesca, Lenci, Ilaria, Pasulo, Luisa, Mazzarelli, Chiara, Ferrarese, Alberto, Rendina, Maria, Grieco, Antonio, Lanza, Alfonso Galeota, Baroni, Gianluca Svegliati, De Maria, Nicola, Marenco, Simona, Mameli, Laura, Ponziani, Francesca Romana, and Vitale, Giovanni

Abstract

Primary sclerosing cholangitis is a cholestatic disease with a low prevalence in Italy. Indications for liver transplantation and the time of listing are not stated. We performed a national survey to investigate the listing criteria, comorbidities, and outcomes. In April 2022, we surveyed liver transplantation in primary sclerosing cholangitis nationwide for the last 15 years. From 2007 to 2021, 445 patients were included on waiting lists, and 411 had undergone liver transplants. The median age at transplantation was 46 years (males 63.9%); 262 patients (59%) presented an inflammatory bowel disease. Transplants increased over the years, from 1.8 % in 2007 to 3.0 % in 2021. Cholangitis (51%) and hepatic decompensation (45%) were the main indications for listing. The disease recurred in 81 patients (20%). Patient survival after the first transplant was 94 %, 86% and 84% at one, five, and ten years. Twenty-four died in the first year (50% surgical complications, 25% infections); 33 between one to five years (36% recurrence, 21% cholangiocarcinoma recurrence) and nine after five years (56% de novo cancer, 44% recurrence). Primary sclerosing cholangitis has been an increasing indication for transplantation in Italy. Cholangitis and decompensation were the main indications for listing. Recurrence and cancer were the leading causes of death. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Evolution of Liver Transplantation Indications: Expanding Horizons

Author

Battistella, Sara, primary, Grasso, Marco, additional, Catanzaro, Elisa, additional, D’Arcangelo, Francesca, additional, Corrà, Giorgia, additional, Germani, Giacomo, additional, Senzolo, Marco, additional, Zanetto, Alberto, additional, Ferrarese, Alberto, additional, Gambato, Martina, additional, Burra, Patrizia, additional, and Russo, Francesco Paolo, additional

Published
2024
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19. The role of an integrated referral program for patients with liver disease: A network between hub and spoke centers

Author

Germani, Giacomo, primary, Ferrarese, Alberto, additional, D’Arcangelo, Francesca, additional, Russo, Francesco Paolo, additional, Senzolo, Marco, additional, Gambato, Martina, additional, Zanetto, Alberto, additional, Cillo, Umberto, additional, Feltracco, Paolo, additional, Persona, Paolo, additional, Serra, Eugenio, additional, Feltrin, Giuseppe, additional, Carretta, Giovanni, additional, Capizzi, Alfio, additional, Donato, Daniele, additional, Tessarin, Michele, additional, and Burra, Patrizia, additional

Published
2023
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21. Allocation of liver grafts worldwide – Is there a best system?

Author

Lendoire, Javier, Imventarza, Oscar, Crawford, Michael, Andraus, Wellington, D'Albuquerque, Luiz Augusto Carneiro, Hernandez-Alejandro, Roberto, Dokus, M. Katherine, Tomiyama, Koji, Zheng, Shusen, Echeverri, Gabriel Jaime, Taimr, Pavel, Fronek, Jiri, de Rosner-van Rosmalen, Marieke, Vogelaar, Serge, Lesurtel, Mickael, Mabrut, Jean-Yves, Nagral, Sanjay, Kakaei, Farzad, Malek-Hosseini, Seyed Ali, Egawa, Hiroto, Contreras, Alan, Czerwinski, Jaroslaw, Danek, Teresa, Pinto-Marques, Hugo, Gautier, Sergey V., Monakhov, Artem, Melum, Espen, Ericzon, Bo-Göran, Kang, Koo Jeong, Kim, Myoung Soo, Sanchez-Velazquez, Patricia, Oberkofler, Christian Eugen, Müllhaupt, Beat, Linecker, Michael, Eshmuminov, Dilmurodjon, Grochola, Lukasz Filip, Song, Zhoulon, Kambakamba, Patryk, Chen, Chao-Long, Haberal, Mehmet, Yilmaz, Sezai, Rowe, Ian A.C., Kron, Philipp, Tschuor, Christoph, Ferrarese, Alberto, Kuemmerli, Christoph, Dutkowski, Philipp, Burra, Patrizia, and Clavien, Pierre-Alain

Published
2019
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23. Predicting survival in patients with ‘non-high-risk’ acute variceal bleeding receiving β-blockers+ligation to prevent re-bleeding

Author

Balcar, Lorenz, primary, Mandorfer, Mattias, additional, Hernández-Gea, Virginia, additional, Procopet, Bogdan, additional, Meyer, Elias Laurin, additional, Giráldez, Álvaro, additional, Amitrano, Lucio, additional, Villanueva, Candid, additional, Thabut, Dominique, additional, Samaniego, Luis Ibáñez, additional, Silva-Junior, Gilberto, additional, Martinez, Javier, additional, Genescà, Joan, additional, Bureau, Christophe, additional, Trebicka, Jonel, additional, Llop Herrera, Elba, additional, Laleman, Wim, additional, Palazón Azorín, José María, additional, Castellote Alonso, Jose, additional, Gluud, Lise Lotte, additional, Noronha Ferreira, Carlos, additional, Cañete, Nuria, additional, Rodríguez, Manuel, additional, Ferlitsch, Arnulf, additional, Mundi, Jose Luis, additional, Grønbæk, Henning, additional, Hernandez Guerra, Manuel Nicolas, additional, Sassatelli, Romano, additional, Dell'Era, Alessandra, additional, Senzolo, Marco, additional, Abraldes, Juan Gonzalez, additional, Romero-Gómez, Manuel, additional, Zipprich, Alexander, additional, Casas, Meritxell, additional, Masnou, Helena, additional, Primignani, Massimo, additional, Krag, Aleksander, additional, Nevens, Frederik, additional, Calleja, Jose Luis, additional, Jansen, Christian, additional, Vega Catalina, María, additional, Albillos, Agustín, additional, Rudler, Marika, additional, Tapias, Edilmar Alvarado, additional, Guardascione, Maria Anna, additional, Tantau, Marcel, additional, Schwarzer, Rémy, additional, Reiberger, Thomas, additional, Laursen, Stig Borbjerg, additional, Lopez-Gomez, Marta, additional, Cachero, Alba, additional, Ferrarese, Alberto, additional, Ripoll, Cristina, additional, La Mura, Vincenzo, additional, Bosch, Jaime, additional, and García-Pagán, Juan Carlos, additional

Published
2023
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24. Evolution of liver fibrosis in diabetic patients with NAFLD in a follow-up study: Hepatoprotective effects of sodium-glucose co-transporter-2 inhibitors

Author

Lombardi, Rosa, primary, Mantovani, Alessandro, additional, Cespiati, Annalisa, additional, Francione, Paolo, additional, Maffi, Gabriele, additional, Del Zanna, Elena, additional, Maffeis, Claudio, additional, Colecchia, Antonio, additional, Passigato, Nicola, additional, Ferrarese, Alberto, additional, Cusumanu, Caterina Daniela, additional, Villani, Rosanna, additional, Orsi, Emanuela, additional, Grancini, Valeria, additional, Airaghi, Lorena, additional, Bignamini, Daniela, additional, Serviddio, Gaetano, additional, Targher, Giovanni, additional, Dongiovanni, Paola, additional, Fargion, Silvia, additional, and Fracanzani, Anna Ludovica, additional

Published
2023
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25. The non‐invasive evaluation of liver involvement in patients with cystic fibrosis: A prospective study

Author

Dajti, Elton, primary, Ravaioli, Federico, additional, Paiola, Giulia, additional, Volpi, Sonia, additional, Colecchia, Luigi, additional, Ferrarese, Alberto, additional, Alemanni, Luigina Vanessa, additional, Cusumano, Caterina, additional, Di Biase, Anna Rita, additional, Marasco, Giovanni, additional, Vestito, Amanda, additional, Festi, Davide, additional, Rautou, Pierre‐Emmanuel, additional, Cipolli, Marco, additional, and Colecchia, Antonio, additional

Published
2023
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27. Long-Term Impact of Direct-Acting Antivirals on Liver Fibrosis and Survival in HCV-Infected Liver Transplant Recipients

Author

Gambato, Martina, primary, Manuli, Chiara, additional, Lynch, Erica N., additional, Battistella, Sara, additional, Germani, Giacomo, additional, Senzolo, Marco, additional, Zanetto, Alberto, additional, Ferrarese, Alberto, additional, Vitale, Alessandro, additional, Gringeri, Enrico, additional, Cillo, Umberto, additional, Burra, Patrizia, additional, and Russo, Francesco Paolo, additional

Published
2023
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28. Epidemiological and clinical profile of HDV infected people in care in Italy: interim analysis from the ongoing PITER cohort

Author

Kondili, Loreta, primary, Tosti, Maria Elena, additional, Quaranta, Maria Giovanna, additional, Ciancio, Alessia, additional, Messina, Vincenzo, additional, Brancaccio, Giuseppina, additional, Brunetto, Maurizia, additional, Capasso, Mario, additional, Rosato, Valerio, additional, Cacciola, Irene, additional, Pasulo, Luisa, additional, Santantonio, Teresa, additional, Coppola, Carmine, additional, Biliotti, Elisa, additional, Barbaro, Francesco, additional, Massari, Marco, additional, Coppola, Nicola, additional, Ferrarese, Alberto, additional, Russo, Francesco Paolo, additional, Di Marco, Vito, additional, Marrone, Aldo, additional, Schivazappa, Simona, additional, Federico, Alessandro, additional, Blanc, Pierluigi, additional, Rocco, Alba, additional, Morsica, Giulia, additional, Ieluzzi, Donatella, additional, Conti, Fabio, additional, De Siena, Martina, additional, Bavetta, Maria Grazia, additional, Milella, Michele, additional, Gentile, Ivan, additional, Porcu, Carmen, additional, Chemello, Liliana, additional, Maracci, Monia, additional, Zignego, Anna Linda, additional, Baiocchi, Leonardo, additional, Maida, Ivana Rita, additional, and Coco, Barbara, additional

Published
2023
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29. The non-invasive evaluation of vascular liver disease in patients with cystic fibrosis: a prospective cross-sectional study

Author

Dajti, Elton, primary, Ravaioli, Federico, additional, Paiola, Giulia, additional, Volpi, Sonia, additional, Colecchia, Luigi, additional, Ferrarese, Alberto, additional, Alemanni, Luigina Vanessa, additional, Cusumano, Caterina, additional, Di Biase, Annarita, additional, Marasco, Giovanni, additional, Vestito, Amanda, additional, Festi, Davide, additional, Rautou, Pierre-Emmanuel, additional, Cipolli, Marco, additional, and Colecchia, Antonio, additional

Published
2023
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30. Prophylaxis of HBV-recurrence after liver transplantation in patients with HCC: risk of HCC recurrence from a large, multicentre retrospective study from Italy

Author

Burra, Patrizia, primary, Battistella, Sara, additional, Russo, Francesco Paolo, additional, Turco, Laura, additional, Manuli, Chiara, additional, Calleri, Alberto, additional, Pasulo, Luisa, additional, Giannelli, Valerio, additional, DiBenedetto, Clara, additional, Mameli, Laura, additional, Ferrarese, Alberto, additional, Marenco, Simona, additional, Ferri, Flaminia, additional, Lenci, Ilaria, additional, Forastiere, Domenico, additional, Schiavone, Silvia, additional, Vero, Vittoria, additional, Vizioli, Luca, additional, Carroli, Agnese, additional, Frassanito, Gabriella, additional, Scandali, Giulia, additional, Biolato, Marco, additional, Fornasiere, Ezio, additional, Ponziani, Francesca, additional, Svegliati-Baroni, Gianluca, additional, Giannini, Edoardo Giovanni, additional, Toniutto, Pierluigi, additional, Lanza, Alfonso Galeota, additional, Rendina, Maria Grazia, additional, Donato, Maria Francesca, additional, Fagiuoli, Stefano, additional, De Maria, Nicola, additional, Morelli, Maria Cristina, additional, Martini, Silvia, additional, Trapani, Silvia, additional, Grossi, Paolo Antonio, additional, Aghemo, Alessio, additional, and Zanetto, Alberto, additional

Published
2023
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31. Primary sclerosing cholangitis recurrence after liver transplantation: a nationwide survey in Italy

Author

Morelli, Maria Cristina, primary, Gambato, Martina, additional, Martini, Silvia, additional, Carrai, Paola, additional, Toniutto, Pierluigi, additional, Giannelli, Valerio, additional, Donato, Maria Francesca, additional, Lenci, Ilaria, additional, Pasulo, Luisa, additional, Mazzarelli, Chiara, additional, Ferrarese, Alberto, additional, Rendina, Maria Grazia, additional, Grieco, Antonio, additional, Lanza, Alfonso Galeota, additional, Svegliati-Baroni, Gianluca, additional, De Maria, Nicola, additional, Mameli, Laura, additional, Marenco, Simona, additional, and Burra, Patrizia, additional

Published
2023
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32. Increased level of presepsin in patients with acutely decompensated cirrhosis predicts development of acute-on-chronic liver failure

Author

Zanetto, Alberto, primary, Mion, Monica, additional, Ferrarese, Alberto, additional, Shalaby, Sarah, additional, Germani, Giacomo, additional, Gambato, Martina, additional, Russo, Francesco Paolo, additional, Farinati, Fabio, additional, Basso, Daniela, additional, Burra, Patrizia, additional, and Senzolo, Marco, additional

Published
2023
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35. Trends in chronic hepatitis B virus infection in Italy over a 10-year period: Clues from the nationwide PITER and MASTER cohorts toward elimination

Author

Brancaccio, Giuseppina, primary, Coco, Barbara, additional, Nardi, Alessandra, additional, Quaranta, Maria Giovanna, additional, Tosti, Maria Elena, additional, Ferrigno, Luigina, additional, Cacciola, Irene, additional, Messina, Vincenzo, additional, Chessa, Luchino, additional, Morisco, Filomena, additional, Milella, Michele, additional, Barbaro, Francesco, additional, Ciancio, Alessia, additional, Russo, Francesco Paolo, additional, Coppola, Nicola, additional, Blanc, Pierluigi, additional, Claar, Ernesto, additional, Verucchi, Gabriella, additional, Puoti, Massimo, additional, Zignego, Anna Linda, additional, Chemello, Liliana, additional, Madonia, Salvatore, additional, Fagiuoli, Stefano, additional, Marzano, Alfredo, additional, Ferrari, Carlo, additional, Lampertico, Pietro, additional, Di Marco, Vito, additional, Craxì, Antonio, additional, Santantonio, Teresa Antonia, additional, Raimondo, Giovanni, additional, Brunetto, Maurizia R., additional, Gaeta, Giovanni Battista, additional, Kondili, Loreta A., additional, Pasulo, Luisa, additional, Coppola, Carmine, additional, Pisano, Federica, additional, Romano, Mariarosaria, additional, Porcu, Carmen, additional, Bottalico, Irene Francesca, additional, Cossiga, Valentina, additional, Tata, Xhimi, additional, Sagnelli, Caterina, additional, Pierotti, Piera, additional, Degasperi, Elisabetta, additional, Rosato, Valerio, additional, Badia, Lorenzo, additional, Ieluzzi, Dontella, additional, Monti, Monica, additional, Bavetta, Maria Grazia, additional, Cavalletto, Luisa, additional, Toniutto, Pierluigi, additional, Fornasiere, Ezio, additional, Colecchia, Antonio, additional, Ferrarese, Alberto, additional, Nardone, Gerardo, additional, Rocco, Alba, additional, Viganò, Mauro, additional, Foschi, Francesco Giuseppe, additional, Conti, Fabio, additional, Morsica, Giulia, additional, Salpietro, Stefania, additional, Torti, Carlo, additional, Costa, Chiara, additional, Federico, Alessandro, additional, Dallio, Marcello, additional, Giorgini, Alessia, additional, Anselmo, Marco, additional, De Leo, Pasqualina, additional, Zaltron, Serena, additional, Cambianica, Anna, additional, Piscaglia, Fabio, additional, Serio, Ilaria, additional, Schivazappa, Simona, additional, Mastroianni, Antonio, additional, Chidichimo, Luciana, additional, Massari, Marco, additional, Mazzaro, Cesare, additional, Marrone, Aldo, additional, D'Amore, Francesca Maria, additional, D'Offizi, Gianpiero, additional, Licata, Anna, additional, Niro, Grazia Anna, additional, Pollicino, Teresa, additional, and Aghemo, Alessio, additional

Published
2023
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36. The role of an integrated referral program for patients with liver disease: A network between hub and spoke centers

Author

Germani, Giacomo, Ferrarese, Alberto, D’Arcangelo, Francesca, Russo, Francesco Paolo, Senzolo, Marco, Gambato, Martina, Zanetto, Alberto, Cillo, Umberto, Feltracco, Paolo, Persona, Paolo, Serra, Eugenio, Feltrin, Giuseppe, Carretta, Giovanni, Capizzi, Alfio, Donato, Daniele, Tessarin, Michele, and Burra, Patrizia

Abstract

Access to Liver transplantation (LT) can be affected by several barriers, resulting in delayed referral and increased risk of mortality due to complications of the underlying liver disease. To assess the clinical characteristics and outcomes of patients with acute or chronic liver disease referred using an integrated referral program. An integrated referral program was developed in 1 October 2017 based on email addresses and a 24/7 telephone availability. All consecutive adult patients with liver disease referred for the first time using this referral program were prospectively collected until 1 October 2021. Characteristics and outcomes of inpatients were compared with a historical cohort of patients referred without using the integrated referral program (1 October 2015—1 October 2017). Patients were further divided according to pre‐ and post‐Covid‐19 pandemic. Two hundred eighty‐one referred patients were considered. End stage liver disease was the most common underlying condition (79.3%), 50.5% of patients were referred as inpatients and 74.7% were referred for LT evaluation. When inpatient referrals (n= 142) were compared with the historical cohort (n= 86), a significant increase in acute liver injury due to drugs/herbals and supplements was seen (p= 0.01) as well as an increase in End stage liver disease due to alcohol‐related liver disease and NASH, although not statistically significant. A significant increase in referrals for evaluation for Trans‐jugular intrahepatic portosystemic shunt placement was seen over time (5.6% vs. 1%; p= 0.01) as well as for LT evaluation (84.5% vs. 81%; p= 0.01). Transplant‐free survival was similar between the study and control groups (p= 0.3). The Covid‐19 pandemic did not affect trends of referrals and patient survival. The development of an integrated referral program for patients with liver disease can represent the first step to standardize already existing referral networks between hub and spoke centers. Future studies should focus on the timing of referral according to different etiologies to optimize treatment options and outcomes.

Published
2024
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37. The interplay between sarcopenia and portal hypertension predicts ascites and mortality in cirrhosis

Author

Dajti, Elton, primary, Renzulli, Matteo, additional, Ravaioli, Federico, additional, Marasco, Giovanni, additional, Vara, Giulio, additional, Brandi, Nicolò, additional, Rossini, Benedetta, additional, Colecchia, Luigi, additional, Alemanni, Luigina Vanessa, additional, Ferrarese, Alberto, additional, Vestito, Amanda, additional, Tamè, Mariarosa, additional, Azzaroli, Francesco, additional, Festi, Davide, additional, Golfieri, Rita, additional, and Colecchia, Antonio, additional

Published
2022
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38. Validation of the INCREMENT‐SOT‐CPE score in a large cohort of liver transplant recipients with carbapenem‐resistant Enterobacterales infection

Author

Rinaldi, Matteo, Bonazzetti, Cecilia, Gallo, Mena, Ferraro, Giuseppe, Freire, Maristela, Terrabuio, Débora Raquel Benedita, Tandoi, Francesco, Romagnoli, Renato, De Rosa, Francesco Giuseppe, Mularoni, Alessandra, Ferrarese, Alberto, Burra, Patrizia, Halpern, Marcia, Balbi, Elizabeth, Simkins, Jacques, Abbo, Lilian, Morrás, Ignacio, Cantero, Mireia, Alagna, Laura, Bandera, Alessandra, Clemente, Wanessa Trinidade, Valerio, Maricela, Fernández, Ainhoa, Muñoz, Patricia, Statlender, Liran, Yahav, Dafna, Camargo, Luis Fernando Aranha, Girão, Evelyne Santana, Grossi, Paolo, Viale, Pierluigi, Curti, Stefania, Giannella, Maddalena, Rinaldi M., Bonazzetti C., Gallo M., Ferraro G., Freire M., Terrabuio D.R.B., Tandoi F., Romagnoli R., De Rosa F.G., Mularoni A., Ferrarese A., Burra P., Halpern M., Balbi E., Simkins J., Abbo L., Morrás I., Cantero M., Alagna L., Bandera A., Clemente W.T., Valerio M., Fernández A., Muñoz P., Statlender L., Yahav D., Camargo L.F.A., Girão E.S., Grossi P., Viale P., Curti S., and Giannella M.

Subjects
INCREMENT-SOT-CPE score, Transplantation, Infectious Diseases, CRE infection, liver transplantation, SOT
Abstract

Background: Management of infections due to carbapenemase-resistant Enterobacterales (CRE) in solid organ transplant (SOT) recipients remains a difficult challenge. The INCREMENT-SOT-CPE score has been specifically developed from SOT recipients to stratify mortality risk, but an external validation is lacking.Methods: Multicenter retrospective cohort study of liver transplant (LT) recipients colonized with CRE infection who developed infection after transplant over 7-year period. Primary endpoint was all-cause 30-day mortality from infection onset. A comparison between INCREMENT-SOT-CPE and other selected scores was performed. A two-level mixed effects logistic regression model with random effects for the center was fitted. Performance characteristics at optimal cut-point were calculated. Multivariable Cox regression analysis of risk factors for all-cause 30-day mortality was carried out.Results: Overall, 250 CRE carriers developed infection after LT and were analyzed. The median age was 55 years (interquartile range [IQR]: 46-62) and 157 were males (62.8%). All-cause 30-day mortality was 35.6%. A sequential organ failure assessment (SOFA) score >= 11 showed a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of 69.7%, 76.4%, 62.0%, 82.0%, and 74.0%, respectively. An INCREMENT-SOT-CPE >= 11 reported a sensitivity, specificity, PPV, NPV, and accuracy of 73.0%, 62.1%, 51.6%, 80.6% and 66.0%, respectively. At multivariable analysis acute renal failure, prolonged mechanical ventilation, INCREMENT-SOT-CPE score >= 11 and SOFA score >= 11 were independently associated with all-cause 30-day mortality, while a tigecycline-based targeted regimen was found to be protective.Conclusions: Both INCREMENT-SOT-CPE >= 11 and SOFA >= 11 were identified as strong predictors of all-cause 30-day mortality in a large cohort of CRE carriers developing infection after LT.

Published
2023

40. Editorial: Assessing the Prognosis of Patients With HBV and ACLF—Comorbidities Matter.

Author

Russo, Francesco Paolo and Ferrarese, Alberto

Subjects
*LIVER failure, *HEPATITIS B, *ASIANS, *LIVER transplantation, *LIVER analysis
Abstract

The editorial discusses the importance of assessing the prognosis of patients with hepatitis B virus (HBV) and acute on chronic liver failure (ACLF), emphasizing the impact of comorbidities on patient outcomes. A new scoring system, the age-adjusted Charlson Comorbidity Index (aCCI)-HBV ACLF score, was proposed to improve prognostic accuracy in HBV-related ACLF patients. While the score showed promising results in predicting short- and mid-term mortality, it has limitations in terms of generalizability across different ethnicities and the exclusion of certain comorbidities. Further research is needed to evaluate the effectiveness of the aCCI in identifying the impact of comorbidities on short-term prognosis in ACLF patients. [Extracted from the article]

Published
2024
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43. A Combined Baveno VII and Spleen Stiffness Algorithm to Improve the Noninvasive Diagnosis of Clinically Significant Portal Hypertension in Patients With Compensated Advanced Chronic Liver Disease

Author

Dajti, Elton, primary, Ravaioli, Federico, additional, Marasco, Giovanni, additional, Alemanni, Luigina Vanessa, additional, Colecchia, Luigi, additional, Ferrarese, Alberto, additional, Cusumano, Caterina, additional, Gemini, Stefano, additional, Vestito, Amanda, additional, Renzulli, Matteo, additional, Golfieri, Rita, additional, Festi, Davide, additional, and Colecchia, Antonio, additional

Published
2022
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44. Non-invasive diagnosis of clinically significant portal hypertension and treatment with non-selective beta-blockers: a new paradigm

Author

Dajti, Elton, primary, Ravaioli, Federico, additional, Marasco, Giovanni, additional, Alemanni, Vanessa, additional, Colecchia, Luigi, additional, Ferrarese, Alberto, additional, Cusumano, Caterina, additional, Gemini, Stefano, additional, Vestito, Amanda, additional, Renzulli, Matteo, additional, Golfieri, Rita, additional, Festi, Davide, additional, and Colecchia, Antonio, additional

Published
2022
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45. Dropout rate from the liver transplant waiting list because of hepatocellular carcinoma progression in hepatitis C virus–infected patients treated with direct‐acting antivirals

Author

Zanetto, Alberto, Shalaby, Sarah, Vitale, Alessandro, Mescoli, Claudia, Ferrarese, Alberto, Gambato, Martina, Franceschet, Enrica, Germani, Giacomo, Senzolo, Marco, Romano, Antonietta, Angeli, Paolo, Rugge, Massimo, Farinati, Fabio, Forton, Daniel M., Cillo, Umberto, Burra, Patrizia, and Russo, Francesco Paolo

Published
2017
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49. The interplay between sarcopenia and portal hypertension predicts ascites and mortality in cirrhosis.

Author

Dajti, Elton, Renzulli, Matteo, Ravaioli, Federico, Marasco, Giovanni, Vara, Giulio, Brandi, Nicolò, Rossini, Benedetta, Colecchia, Luigi, Alemanni, Luigina Vanessa, Ferrarese, Alberto, Vestito, Amanda, Tamè, Mariarosa, Azzaroli, Francesco, Festi, Davide, Golfieri, Rita, and Colecchia, Antonio

Abstract

The role of sarcopenia in predicting decompensation other than hepatic encephalopathy is unclear. We aimed to evaluate the prognostic role of sarcopenia, assessed by computed tomography (CT), in the development of ascites and mortality in patients with advanced chronic liver disease (ACLD) outside the liver transplantation (LT) setting. We retrospectively evaluated ACLD patients with liver stiffness measurement (LSM) >10 kPa and an available CT scan within 6 months. Sarcopenia was defined as skeletal muscle index (SMI) <50 and <39 cm2/m2, respectively, in men and women. Competing risk regression models were used to assess the variables associated with the main outcomes. 209 patients were included in the final analysis and sarcopenia was present in 134 (64.1%). During a median follow-up of 37 (20–63) months, 52 patients developed ascites, 24 underwent LT, and 30 died. Sarcopenia was found a predictive factor of decompensation with ascites (SHR 2.083, 95%-CI: 1.091–3.978), independently from the features of clinically significant portal hypertension (LSM≥21 kPa or portosystemic shunts). Sarcopenia (SHR: 2.744, 95%-CI: 1.105–6.816) and LSM≥21 kPa (SHR: 3.973, 95%-CI: 1.548–10.197) were independent risk factors for increased mortality. Sarcopenia and portal hypertension are two major and independent risk factors for decompensation with ascites and mortality in cirrhotic patients outside the LT context. [ABSTRACT FROM AUTHOR]

Published
2023
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